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PMC:3585731 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T456 0-3 Protein denotes Akt
T461 4-13 Regulation denotes Regulates
T457 14-18 Protein denotes TNFα
T459 19-28 Gene_expression denotes Synthesis
T458 43-54 Protein denotes RIP1 Kinase
T460 55-65 Positive_regulation denotes Activation
T465 404-414 Regulation denotes controlled
T464 404-414 Regulation denotes controlled
T462 434-473 Protein denotes mediator receptor interacting protein-1
T463 475-479 Protein denotes RIP1
T466 502-512 Protein denotes Akt kinase
T467 588-592 Protein denotes TNFα
T468 593-603 Gene_expression denotes production
T469 625-628 Protein denotes Akt
T474 632-641 Positive_regulation denotes activated
T472 632-641 Positive_regulation denotes activated
T470 647-651 Protein denotes RIP1
T473 682-697 Phosphorylation denotes phosphorylation
T471 701-707 Protein denotes Thr308
T475 807-811 Protein denotes RIP1
T476 920-923 Protein denotes Akt
T477 973-977 Protein denotes RIP1
T478 981-984 Protein denotes JNK
T481 985-995 Positive_regulation denotes activation
T480 985-995 Positive_regulation denotes activation
T479 1024-1028 Protein denotes TNFα
T484 1113-1120 Regulation denotes control
T482 1149-1153 Protein denotes TNFα
T483 1154-1164 Gene_expression denotes production
T485 1293-1303 Protein denotes Akt kinase
T486 1340-1350 Regulation denotes regulation
T2153 2132-2136 Protein denotes RIP1
T2154 2141-2145 Protein denotes RIP3
T2156 2300-2307 Positive_regulation denotes induced
T2155 2319-2326 Protein denotes caspase
T2160 2703-2712 Positive_regulation denotes activated
T2159 2703-2712 Positive_regulation denotes activated
T2157 2757-2761 Protein denotes RIP1
T2158 2766-2770 Protein denotes RIP3
T2161 2869-2879 Protein denotes JNK kinase
T2163 2880-2890 Positive_regulation denotes activation
T2162 2964-2975 Protein denotes RIP1 kinase
T2164 3047-3050 Protein denotes JNK
T2167 3119-3129 Positive_regulation denotes Activation
T2165 3133-3136 Protein denotes JNK
T2166 3170-3184 Protein denotes autocrine TNFα
T2168 3185-3194 Gene_expression denotes synthesis
T6709 3308-3319 Protein denotes RIP1 kinase
T2169 3308-3319 Protein denotes RIP1 kinase
T2175 3330-3340 Positive_regulation denotes activation
T2174 3330-3340 Positive_regulation denotes activation
T2170 3344-3347 Protein denotes JNK
T2171 3352-3356 Protein denotes TNFα
T2173 3357-3367 Gene_expression denotes production
T2172 3357-3367 Gene_expression denotes production
T2176 3458-3468 Protein denotes Akt kinase
T2177 3627-3634 Protein denotes insulin
T2179 3645-3655 Positive_regulation denotes activation
T2178 3659-3662 Protein denotes Akt
T2180 4106-4113 Protein denotes insulin
T2184 4114-4123 Positive_regulation denotes dependent
T2181 4124-4127 Protein denotes Akt
T2182 4200-4203 Protein denotes Akt
T2185 4204-4214 Positive_regulation denotes activation
T2183 4284-4295 Protein denotes RIP1 kinase
T2186 4435-4438 Protein denotes Akt
T2187 4443-4446 Protein denotes JNK
T2188 4472-4483 Protein denotes RIP1 kinase
T2189 4525-4528 Protein denotes Akt
T2191 4532-4541 Positive_regulation denotes activated
T15344 4550-4561 Protein denotes RIP1 kinase
T2190 4550-4561 Protein denotes RIP1 kinase
T15353 4562-4571 Positive_regulation denotes dependent
T15350 4579-4594 Phosphorylation denotes phosphorylation
T2192 4698-4704 Protein denotes mTORC1
T2193 4709-4711 Protein denotes S6
T2197 4712-4723 Positive_regulation denotes contributes
T2196 4731-4741 Positive_regulation denotes activation
T2194 4761-4765 Protein denotes TNFα
T2195 4766-4776 Gene_expression denotes production
T2198 4796-4799 Protein denotes Akt
T2199 4842-4853 Protein denotes RIP1 kinase
T2200 4858-4861 Protein denotes JNK
T2201 4862-4872 Positive_regulation denotes activation
T2202 4955-4959 Protein denotes FADD
T2203 5076-5080 Protein denotes TNFα
T2204 5081-5091 Gene_expression denotes production
T2205 5197-5200 Protein denotes Akt
T4083 5472-5481 Protein denotes TNFα [10]
T4084 5516-5523 Protein denotes caspase
T4085 5593-5600 Protein denotes caspase
T4086 5612-5620 Protein denotes zVAD.fmk
T4087 5987-5994 Protein denotes caspase
T4092 6231-6235 Negative_regulation denotes loss
T4088 6239-6246 Protein denotes caspase
T4089 6411-6418 Protein denotes caspase
T4094 6449-6460 Positive_regulation denotes inactivates
T4093 6449-6460 Positive_regulation denotes inactivates
T4090 6461-6472 Protein denotes RIP1 kinase
T4091 6481-6500 Protein denotes RIP1 deubiquitinase
T4097 6629-6638 Negative_regulation denotes prevented
T4095 6666-6674 Protein denotes zVAD.fmk
T4096 6676-6683 Protein denotes Fig. 1A
T4098 6726-6730 Protein denotes bFGF
T4099 6732-6749 Protein denotes restored zVAD.fmk
T4100 6920-6924 Protein denotes bFGF
T4101 6929-6934 Protein denotes IGF-1
T4102 6944-6947 Protein denotes EGF
T4103 6952-6956 Protein denotes PDGF
T4106 7046-7056 Negative_regulation denotes inhibition
T4104 7060-7067 Protein denotes caspase
T4105 7081-7085 Protein denotes bFGF
T4107 7142-7146 Protein denotes TNFα
T4108 7266-7274 Protein denotes zVAD.fmk
T4109 7278-7282 Protein denotes TNFα
T28706 7377-7381 Protein denotes bFGF
T28707 7386-7391 Protein denotes IGF-1
T28708 7428-7436 Protein denotes zVAD.fmk
T28709 7471-7475 Protein denotes TNFα
T28710 7479-7487 Protein denotes zVAD.fmk
T28711 7831-7836 Protein denotes Nec-1
T28712 7975-7978 Protein denotes FGF
T28713 7980-7988 Protein denotes zVAD.fmk
T28714 8068-8084 Protein denotes zVAD.fmk or TNFα
T28715 8133-8144 Protein denotes µM PD173074
T28716 8152-8163 Protein denotes µM PD166866
T4113 8294-8303 Negative_regulation denotes inhibitor
T4110 8307-8318 Protein denotes RIP1 kinase
T4111 8336-8339 Protein denotes Fig
T4112 8341-8344 Protein denotes S1A
T4116 8491-8498 Negative_regulation denotes blocked
T4114 8593-8601 Protein denotes zVAD.fmk
T4115 8606-8610 Protein denotes TNFα
T4117 8707-8711 Protein denotes RIP1
T4118 8765-8768 Protein denotes Fig
T4119 8770-8773 Protein denotes S1A
T4121 8845-8849 Negative_regulation denotes loss
T4120 8853-8864 Protein denotes RIP1 kinase
T4122 8900-8906 Protein denotes Nec-1i
T4123 8980-8988 Protein denotes zVAD.fmk
T4124 8992-8996 Protein denotes TNFα
T4125 8998-9006 Protein denotes Fig. S1B
T4126 9046-9059 Protein denotes bFGF/zVAD.fmk
T4127 9061-9064 Protein denotes Fig
T4128 9066-9069 Protein denotes S1C
T4129 9091-9102 Protein denotes RIP1 kinase
T4130 9217-9221 Protein denotes bFGF
T4131 9319-9348 Protein denotes bFGF receptor tyrosine kinase
T4132 9419-9423 Protein denotes bFGF
T4133 9453-9457 Protein denotes zVAD
T4134 9458-9461 Protein denotes fmk
T4135 9544-9557 Protein denotes bFGF receptor
T4137 9558-9567 Negative_regulation denotes inhibitor
T4136 9590-9594 Protein denotes TNFα
T4138 9768-9776 Protein denotes zVAD.fmk
T4139 9792-9796 Protein denotes bFGF
T6713 10117-10126 Positive_regulation denotes dependent
T6711 10127-10137 Positive_regulation denotes Activation
T6710 10141-10144 Protein denotes Akt
T6712 10145-10156 Positive_regulation denotes Contributes
T6714 10316-10320 Protein denotes MAPK
T6715 10381-10403 Protein denotes growth factor receptor
T6716 10404-10414 Positive_regulation denotes activation
T6721 10426-10436 Negative_regulation denotes Inhibition
T6717 10440-10443 Protein denotes Akt
T6718 10445-10448 Protein denotes Akt
T6719 10595-10599 Protein denotes bFGF
T6720 10603-10617 Protein denotes IGF-1/zVAD.fmk
T6725 10657-10667 Negative_regulation denotes Inhibition
T6722 10671-10674 Protein denotes Akt
T6723 10750-10754 Protein denotes TNFα
T6724 10756-10763 Protein denotes Fig. 2A
T6726 10804-10807 Protein denotes JNK
T6727 10857-10865 Protein denotes zVAD.fmk
T6728 10870-10874 Protein denotes TNFα
T6729 10890-10899 Protein denotes Fig. 2A,B
T6730 10904-10907 Protein denotes Fig
T6731 10909-10912 Protein denotes S2A
T6736 10939-10949 Negative_regulation denotes inhibition
T6735 10939-10949 Negative_regulation denotes inhibition
T6732 10970-10973 Protein denotes p38
T6733 10978-10981 Protein denotes ERK
T6734 11076-11092 Protein denotes zVAD.fmk or TNFα
T29144 11162-11165 Protein denotes Akt
T29145 11204-11212 Protein denotes zVAD.fmk
T29146 11217-11221 Protein denotes TNFα
T29155 11229-11240 Entity denotes Necroptosis
T29147 11256-11272 Protein denotes zVAD.fmk or TNFα
T29169 11351-11361 Negative_regulation denotes inhibitors
T29168 11351-11361 Negative_regulation denotes inhibitors
T29167 11351-11361 Negative_regulation denotes inhibitors
T29166 11351-11361 Negative_regulation denotes inhibitors
T29161 11351-11361 Negative_regulation denotes inhibitors
T29160 11351-11361 Negative_regulation denotes inhibitors
T29159 11351-11361 Negative_regulation denotes inhibitors
T29158 11351-11361 Negative_regulation denotes inhibitors
T29157 11351-11361 Negative_regulation denotes inhibitors
T29156 11351-11361 Negative_regulation denotes inhibitors
T29148 11365-11368 Protein denotes Akt
T29149 11370-11373 Protein denotes Akt
T29165 11374-11383 Negative_regulation denotes inhibitor
T29164 11374-11383 Negative_regulation denotes inhibitor
T29163 11374-11383 Negative_regulation denotes inhibitor
T29162 11374-11383 Negative_regulation denotes inhibitor
T29150 11391-11394 Protein denotes JNK
T29151 11407-11410 Protein denotes p38
T29152 11412-11420 Protein denotes PD169316
T29153 11427-11430 Protein denotes Erk
T29154 11432-11437 Protein denotes UO126
T29179 11499-11510 Positive_regulation denotes transfected
T29178 11499-11510 Positive_regulation denotes transfected
T29177 11499-11510 Positive_regulation denotes transfected
T29176 11499-11510 Gene_expression denotes transfected
T29175 11499-11510 Gene_expression denotes transfected
T29174 11499-11510 Gene_expression denotes transfected
T29170 11516-11520 Protein denotes Akt1
T29171 11522-11526 Protein denotes Akt2
T29172 11532-11543 Protein denotes Akt3 siRNAs
T29173 11573-11589 Protein denotes zVAD.fmk or TNFα
T29180 11620-11623 Protein denotes Akt
T29181 11624-11634 Gene_expression denotes expression
T6737 11772-11775 Protein denotes Akt
T6738 11825-11828 Protein denotes Akt
T6743 11829-11839 Negative_regulation denotes inhibitors
T6742 11829-11839 Negative_regulation denotes inhibitors
T6739 11860-11877 Protein denotes allosteric kinase
T6744 11878-11887 Negative_regulation denotes inhibitor
T6746 11935-11941 Negative_regulation denotes blocks
T6745 11951-11964 Localization denotes translocation
T6740 11968-11971 Protein denotes Akt
T6741 12001-12009 Protein denotes Fig. S2B
T6755 12035-12044 Negative_regulation denotes knockdown
T6754 12035-12044 Negative_regulation denotes knockdown
T6753 12035-12044 Negative_regulation denotes knockdown
T6747 12048-12051 Protein denotes Akt
T6748 12061-12065 Protein denotes Akt1
T6749 12070-12074 Protein denotes Akt2
T6756 12088-12097 Gene_expression denotes protected
T6750 12137-12145 Protein denotes zVAD.fmk
T6751 12150-12154 Protein denotes TNFα
T6752 12156-12163 Protein denotes Fig. 2C
T6759 12169-12179 Gene_expression denotes expression
T6757 12183-12187 Protein denotes Akt3
T6758 12241-12251 Protein denotes Akt3 siRNA
T6760 12320-12323 Protein denotes Akt
T6767 12417-12427 Positive_regulation denotes activation
T6766 12417-12427 Positive_regulation denotes activation
T6761 12431-12434 Protein denotes Akt
T6762 12439-12442 Protein denotes JNK
T6773 12489-12496 Regulation denotes changes
T6772 12489-12496 Regulation denotes changes
T6771 12489-12496 Regulation denotes changes
T6763 12500-12503 Protein denotes Akt
T6764 12508-12511 Protein denotes JNK
T6769 12512-12527 Phosphorylation denotes phosphorylation
T6768 12512-12527 Phosphorylation denotes phosphorylation
T6765 12555-12559 Protein denotes TNFα
T6770 12560-12571 Positive_regulation denotes stimulation
T6774 12713-12721 Protein denotes zVAD.fmk
T6775 12725-12729 Protein denotes TNFα
T6778 12751-12759 Positive_regulation denotes increase
T6776 12763-12766 Protein denotes Akt
T6777 12767-12782 Phosphorylation denotes phosphorylation
T6782 12881-12896 Phosphorylation denotes phosphorylation
T6781 12881-12896 Phosphorylation denotes phosphorylation
T6784 12897-12904 Regulation denotes changes
T6783 12897-12904 Regulation denotes changes
T6779 12944-12947 Protein denotes Akt
T6780 12949-12955 Protein denotes Ser473
T6793 12977-12985 Positive_regulation denotes increase
T6792 12977-12985 Positive_regulation denotes increase
T6791 12977-12985 Positive_regulation denotes increase
T6790 12993-13008 Phosphorylation denotes phosphorylation
T6789 12993-13008 Phosphorylation denotes phosphorylation
T6788 12993-13008 Phosphorylation denotes phosphorylation
T6785 13021-13024 Protein denotes p46
T6786 13029-13032 Protein denotes p54
T6787 13045-13048 Protein denotes JNK
T6794 13120-13123 Protein denotes Akt
T6795 13128-13131 Protein denotes JNK
T6797 13136-13145 Positive_regulation denotes activated
T6796 13136-13145 Positive_regulation denotes activated
T29678 13220-13231 Protein denotes RIP1 kinase
T29684 13232-13241 Positive_regulation denotes dependent
T29683 13232-13241 Positive_regulation denotes dependent
T29682 13242-13257 Phosphorylation denotes phosphorylation
T29681 13242-13257 Phosphorylation denotes phosphorylation
T29679 13261-13264 Protein denotes Akt
T29680 13269-13272 Protein denotes JNK
T29685 13326-13334 Protein denotes zVAD.fmk
T29686 13338-13342 Protein denotes TNFα
T29687 13460-13473 Protein denotes bFGF/zVAD.fmk
T29688 13624-13628 Protein denotes bFGF
T29689 13632-13641 Protein denotes bFGF/zVAD
T6798 13745-13756 Protein denotes RIP1 kinase
T6799 13768-13773 Protein denotes Nec-1
T6807 13786-13795 Negative_regulation denotes prevented
T6806 13800-13808 Positive_regulation denotes increase
T6800 13812-13822 Protein denotes Thr308 Akt
T6805 13823-13838 Phosphorylation denotes phosphorylation
T6801 13846-13852 Protein denotes Nec-1i
T6802 13862-13869 Protein denotes Fig. 3A
T6803 13871-13874 Protein denotes Fig
T6804 13876-13879 Protein denotes S1D
T6808 13893-13898 Protein denotes Nec-1
T6813 13899-13908 Negative_regulation denotes prevented
T6812 13913-13922 Positive_regulation denotes induction
T6809 13926-13929 Protein denotes JNK
T6811 13930-13945 Phosphorylation denotes phosphorylation
T6810 14014-14018 Protein denotes TNFα
T6815 14046-14053 Regulation denotes changes
T6814 14081-14084 Protein denotes JNK
T6816 14218-14223 Protein denotes Nec-1
T6817 14238-14243 Protein denotes Nec-1
T6823 14268-14283 Phosphorylation denotes phosphorylation
T6822 14268-14283 Phosphorylation denotes phosphorylation
T6821 14268-14283 Phosphorylation denotes phosphorylation
T6818 14301-14304 Protein denotes Akt
T6819 14308-14311 Protein denotes JNK
T6820 14313-14320 Protein denotes Fig. 3A
T6824 14345-14355 Protein denotes Akt Thr308
T6825 14360-14363 Protein denotes JNK
T6828 14364-14379 Phosphorylation denotes phosphorylation
T6827 14364-14379 Phosphorylation denotes phosphorylation
T6826 14402-14406 Protein denotes RIP1
T6832 14407-14416 Positive_regulation denotes dependent
T6831 14407-14416 Positive_regulation denotes dependent
T6830 14407-14416 Positive_regulation denotes dependent
T6829 14407-14416 Positive_regulation denotes dependent
T6841 14456-14471 Phosphorylation denotes phosphorylation
T6840 14456-14471 Phosphorylation denotes phosphorylation
T6839 14456-14471 Phosphorylation denotes phosphorylation
T6833 14475-14485 Protein denotes Akt Thr308
T6834 14487-14490 Protein denotes JNK
T6835 14495-14498 Protein denotes Jun
T6836 14530-14533 Protein denotes fmk
T6837 14626-14629 Protein denotes Fig
T6838 14631-14634 Protein denotes S3A
T6846 14662-14675 Regulation denotes contributions
T6844 14662-14675 Regulation denotes contributions
T6842 14698-14709 Protein denotes RIP1 kinase
T6845 14725-14735 Regulation denotes regulation
T6843 14739-14742 Protein denotes Akt
T6852 14857-14865 Positive_regulation denotes addition
T6847 14869-14873 Protein denotes bFGF
T6848 14903-14911 Protein denotes zVAD.fmk
T6859 14953-14961 Positive_regulation denotes increase
T6858 14953-14961 Positive_regulation denotes increase
T6853 14953-14961 Positive_regulation denotes increase
T6854 14970-14976 Entity denotes Thr308
T6855 14981-14987 Entity denotes Ser473
T6857 14988-15003 Phosphorylation denotes phosphorylation
T6856 14988-15003 Phosphorylation denotes phosphorylation
T6849 15007-15010 Protein denotes Akt
T6850 15022-15025 Protein denotes JNK
T6851 15030-15035 Protein denotes c-Jun
T6860 15158-15171 Protein denotes bFGF/zVAD.fmk
T6861 15181-15185 Protein denotes bFGF
T6868 15231-15239 Positive_regulation denotes increase
T6865 15247-15262 Phosphorylation denotes phosphorylation
T6862 15293-15296 Protein denotes Akt
T6870 15318-15326 Positive_regulation denotes increase
T6869 15318-15326 Positive_regulation denotes increase
T6867 15334-15349 Phosphorylation denotes phosphorylation
T6866 15334-15349 Phosphorylation denotes phosphorylation
T6863 15353-15356 Protein denotes JNK
T6864 15361-15364 Protein denotes Jun
T6871 15379-15384 Protein denotes Nec-1
T6895 15424-15432 Positive_regulation denotes increase
T6894 15424-15432 Positive_regulation denotes increase
T6893 15424-15432 Positive_regulation denotes increase
T6886 15424-15432 Positive_regulation denotes increase
T6872 15441-15444 Protein denotes Akt
T6873 15449-15452 Protein denotes JNK
T6874 15453-15458 Protein denotes c-Jun
T6889 15459-15474 Phosphorylation denotes phosphorylation
T6888 15459-15474 Phosphorylation denotes phosphorylation
T6887 15459-15474 Phosphorylation denotes phosphorylation
T6875 15493-15497 Protein denotes bFGF
T6876 15502-15506 Protein denotes bFGF
T6877 15507-15511 Protein denotes zVAD
T6878 15519-15524 Protein denotes Nec-1
T6879 15547-15560 Protein denotes analog Nec-1i
T6880 15562-15565 Protein denotes Fig
T6881 15567-15570 Protein denotes S1E
T6897 15585-15592 Negative_regulation denotes blocked
T6896 15585-15592 Negative_regulation denotes blocked
T6882 15597-15606 Protein denotes bFGF/zVAD
T6890 15607-15615 Positive_regulation denotes increase
T6892 15670-15680 Positive_regulation denotes activation
T6891 15670-15680 Positive_regulation denotes activation
T6883 15684-15687 Protein denotes Akt
T6884 15692-15695 Protein denotes JNK
T6885 15741-15752 Protein denotes RIP1 kinase
T6898 15774-15777 Protein denotes IGF
T6899 15778-15782 Protein denotes zVAD
T6909 15863-15871 Positive_regulation denotes increase
T6908 15863-15871 Positive_regulation denotes increase
T6900 15875-15881 Protein denotes Thr308
T6905 15882-15897 Phosphorylation denotes phosphorylation
T6901 15901-15904 Protein denotes Akt
T6902 15912-15915 Protein denotes IGF
T6911 15956-15964 Positive_regulation denotes increase
T6910 15956-15964 Positive_regulation denotes increase
T6907 15968-15983 Phosphorylation denotes phosphorylation
T6906 15968-15983 Phosphorylation denotes phosphorylation
T6903 15985-15988 Protein denotes Fig
T6904 15990-15993 Protein denotes S3C
T6912 16029-16039 Protein denotes Akt Thr308
T6917 16051-16066 Phosphorylation denotes phosphorylation
T6913 16165-16169 Protein denotes RIP1
T6919 16180-16188 Positive_regulation denotes increase
T6914 16192-16195 Protein denotes Akt
T6918 16203-16218 Phosphorylation denotes phosphorylation
T6915 16220-16223 Protein denotes Fig
T6916 16225-16228 Protein denotes S3D
T6927 16299-16308 Positive_regulation denotes increases
T6926 16299-16308 Positive_regulation denotes increases
T6923 16299-16308 Positive_regulation denotes increases
T6920 16312-16315 Protein denotes Akt
T6921 16320-16323 Protein denotes JNK
T6925 16324-16339 Phosphorylation denotes phosphorylation
T6924 16324-16339 Phosphorylation denotes phosphorylation
T6922 16449-16460 Protein denotes RIP1 kinase
T7943 16463-16487 Protein denotes TNFα Induces Delayed Akt
T7944 16488-16494 Protein denotes Thr308
T7947 16495-16510 Phosphorylation denotes Phosphorylation
T7946 16495-16510 Phosphorylation denotes Phosphorylation
T7945 16542-16555 Protein denotes Growth Factor
T7948 16584-16588 Protein denotes TNFα
T7949 16653-16657 Protein denotes FGFR
T7956 16658-16668 Negative_regulation denotes inhibitors
T7950 16687-16691 Protein denotes TNFα
T7951 16711-16714 Protein denotes Akt
T7952 16718-16721 Protein denotes JNK
T7958 16722-16737 Phosphorylation denotes phosphorylation
T7957 16722-16737 Phosphorylation denotes phosphorylation
T7953 16797-16805 Protein denotes zVAD.fmk
T7954 16807-16810 Protein denotes Fig
T7955 16812-16815 Protein denotes S4A
T7959 16843-16847 Protein denotes TNFα
T7963 16871-16881 Positive_regulation denotes activation
T7960 16885-16893 Protein denotes Akt p308
T7961 16976-16980 Protein denotes TNFα
T7962 16994-17004 Protein denotes Akt Thr308
T7966 17048-17058 Positive_regulation denotes activation
T7964 17062-17065 Protein denotes JNK
T7965 17069-17073 Protein denotes TNFα
T7967 17133-17137 Protein denotes TNFα
T7973 17175-17183 Positive_regulation denotes increase
T7972 17175-17183 Positive_regulation denotes increase
T7971 17191-17206 Phosphorylation denotes phosphorylation
T7970 17191-17206 Phosphorylation denotes phosphorylation
T7968 17210-17213 Protein denotes JNK
T7969 17218-17223 Protein denotes c-Jun
T7974 17225-17230 Protein denotes Nec-1
T7980 17279-17286 Negative_regulation denotes reduced
T7979 17279-17286 Negative_regulation denotes reduced
T7978 17287-17293 Positive_regulation denotes levels
T7977 17287-17293 Positive_regulation denotes levels
T7975 17297-17301 Protein denotes pJNK
T7976 17302-17305 Protein denotes Jun
T7981 17377-17381 Protein denotes RIP1
T7982 17476-17480 Protein denotes Ask1
T7985 17484-17492 Positive_regulation denotes activate
T7983 17493-17496 Protein denotes JNK
T7984 17517-17528 Protein denotes RIP1 kinase
T8735 17698-17709 Protein denotes RIP1 kinase
T8741 17720-17728 Positive_regulation denotes increase
T8740 17720-17728 Positive_regulation denotes increase
T8736 17732-17735 Protein denotes Akt
T8737 17736-17742 Protein denotes Thr308
T8739 17743-17758 Phosphorylation denotes phosphorylation
T8738 17743-17758 Phosphorylation denotes phosphorylation
T8742 17837-17850 Protein denotes PDGF/zVAD.fmk
T8747 17895-17904 Positive_regulation denotes triggered
T8744 17895-17904 Positive_regulation denotes triggered
T8743 17937-17940 Protein denotes JNK
T8745 17941-17956 Phosphorylation denotes phosphorylation
T8746 17985-17995 Positive_regulation denotes activation
T8748 18137-18140 Protein denotes Akt
T8752 18141-18150 Negative_regulation denotes inhibitor
T8749 18234-18242 Protein denotes zVAD.fmk
T8750 18244-18248 Protein denotes TNFα
T8751 18252-18265 Protein denotes bFGF/zVAD.fmk
T8753 18411-18417 Protein denotes Thr308
T8754 18418-18433 Phosphorylation denotes phosphorylation
T8755 18462-18466 Protein denotes bFGF
T8756 18501-18505 Protein denotes bFGF
T8757 18525-18533 Protein denotes PD173074
T8758 18567-18570 Protein denotes Akt
T8759 18571-18581 Positive_regulation denotes activation
T8760 18783-18786 Protein denotes Akt
T8762 18787-18797 Positive_regulation denotes activation
T8763 18902-18912 Positive_regulation denotes activation
T8761 18916-18919 Protein denotes Akt
T29973 19013-19019 Protein denotes Thr308
T29976 19020-19035 Phosphorylation denotes phosphorylation
T29975 19020-19035 Phosphorylation denotes phosphorylation
T29974 19039-19042 Protein denotes Akt
T29978 19043-19054 Positive_regulation denotes contributes
T29977 19043-19054 Positive_regulation denotes contributes
T29979 19104-19112 Protein denotes zVAD.fmk
T29980 19117-19121 Protein denotes bFGF
T29981 19125-19129 Protein denotes PDGF
T29982 19147-19152 Protein denotes Nec-1
T29983 19225-19233 Protein denotes zVAD.fmk
T29984 19237-19241 Protein denotes TNFα
T29985 19243-19244 Protein denotes B
T29986 19249-19262 Protein denotes bFGF/zVAD.fmk
T29987 19296-19299 Protein denotes Akt
T29988 19503-19512 Protein denotes bFGF/zVAD
T29989 19589-19592 Protein denotes FGF
T29990 19593-19597 Protein denotes zVAD
T29991 19738-19742 Protein denotes bFGF
T29992 19743-19747 Protein denotes zVAD
T29993 19748-19751 Protein denotes fmk
T10531 19840-19843 Protein denotes Akt
T10533 20010-20018 Positive_regulation denotes increase
T10532 20022-20032 Protein denotes Akt kinase
T10534 20138-20141 Protein denotes Akt
T10535 20154-20190 Protein denotes Forkhead box class O (FoxO) proteins
T10536 20192-20205 Protein denotes GSK-3 kinases
T10537 20210-20231 Protein denotes mouse double minute 2
T10538 20233-20237 Protein denotes MDM2
T10539 20273-20294 Protein denotes p70 ribosomal protein
T10540 20295-20304 Protein denotes S6 Kinase
T10541 20306-20312 Protein denotes p70S6K
T10542 20345-20350 Protein denotes FoxO1
T10543 20352-20357 Protein denotes FoxO4
T10544 20359-20363 Protein denotes MDM2
T10545 20375-20383 Positive_regulation denotes increase
T10546 20414-20420 Protein denotes FoxO3a
T10547 20422-20438 Protein denotes GSK-3α/β, p70S6K
T10552 20524-20539 Phosphorylation denotes phosphorylation
T10551 20524-20539 Phosphorylation denotes phosphorylation
T10554 20563-20571 Positive_regulation denotes increase
T10548 20575-20578 Protein denotes Akt
T10553 20579-20594 Phosphorylation denotes phosphorylation
T10549 20596-20603 Protein denotes Fig. 5B
T10550 20605-20608 Protein denotes S5A
T10560 20896-20905 Positive_regulation denotes increases
T10555 20909-20912 Protein denotes Akt
T10562 20929-20938 Negative_regulation denotes abrogated
T10561 20929-20938 Negative_regulation denotes abrogated
T10556 20942-20947 Protein denotes Nec-1
T10557 20949-20956 Protein denotes Fig. 5A
T10558 20958-20961 Protein denotes Fig
T10559 20963-20966 Protein denotes S5A
T10563 21045-21048 Protein denotes Akt
T10564 21124-21128 Protein denotes RIP1
T30575 21192-21198 Protein denotes mTORC1
T30576 21278-21294 Protein denotes zVAD.fmk or TNFα
T30577 21390-21394 Protein denotes bFGF
T30578 21398-21407 Protein denotes bFGF/zVAD
T30579 21408-21411 Protein denotes fmk
T30580 21539-21555 Protein denotes zVAD.fmk or TNFα
T30586 21588-21598 Negative_regulation denotes inhibitors
T30585 21588-21598 Negative_regulation denotes inhibitors
T30584 21588-21598 Negative_regulation denotes inhibitors
T30581 21602-21605 Protein denotes Akt
T30582 21606-21609 Protein denotes Akt
T30583 21625-21629 Protein denotes mTOR
T30587 21683-21693 Protein denotes mTOR siRNA
T30589 21694-21703 Negative_regulation denotes knockdown
T30588 21752-21768 Protein denotes zVAD.fmk or TNFα
T10565 21889-21899 Protein denotes Akt kinase
T10568 22171-22181 Negative_regulation denotes inhibition
T10566 22185-22191 Protein denotes mTORC1
T10569 22209-22218 Negative_regulation denotes inhibitor
T10567 22226-22230 Protein denotes mTOR
T10570 22320-22331 Protein denotes mTOR kinase
T10573 22332-22341 Negative_regulation denotes inhibitor
T10571 22367-22371 Protein denotes PI3K
T10572 22372-22376 Protein denotes mTOR
T10575 22377-22386 Negative_regulation denotes inhibitor
T10574 22377-22386 Negative_regulation denotes inhibitor
T10580 22449-22458 Negative_regulation denotes Knockdown
T10576 22462-22478 Protein denotes mTOR using siRNA
T10577 22553-22557 Protein denotes mTOR
T10578 22603-22611 Protein denotes zVAD.fmk
T10579 22616-22620 Protein denotes TNFα
T10581 22646-22652 Protein denotes mTORC1
T10584 22653-22662 Regulation denotes regulates
T10583 22683-22693 Positive_regulation denotes activation
T10582 22697-22709 Protein denotes p70S6 kinase
T10587 23005-23010 Negative_regulation denotes block
T10585 23011-23013 Protein denotes S6
T10586 23014-23029 Phosphorylation denotes phosphorylation
T10591 23059-23068 Negative_regulation denotes knockdown
T10588 23072-23074 Protein denotes S6
T10589 23167-23173 Protein denotes p70S6K
T10590 23174-23176 Protein denotes S6
T10592 23383-23386 Protein denotes Akt
T10593 23422-23433 Protein denotes RIP1 kinase
T10594 23435-23438 Protein denotes Akt
T10595 23440-23446 Protein denotes mTORC1
T10596 23451-23454 Protein denotes JNK
T10602 23455-23462 Regulation denotes control
T10601 23455-23462 Regulation denotes control
T10600 23455-23462 Regulation denotes control
T10599 23455-23462 Regulation denotes control
T10598 23467-23479 Positive_regulation denotes upregulation
T10597 23483-23487 Protein denotes TNFα
T10604 23645-23654 Gene_expression denotes synthesis
T10603 23658-23662 Protein denotes TNFα
T10605 23761-23765 Protein denotes TNFα
T10606 23766-23775 Gene_expression denotes synthesis
T10607 23795-23799 Protein denotes RIP1
T10615 23810-23818 Positive_regulation denotes increase
T10614 23810-23818 Positive_regulation denotes increase
T10608 23822-23834 Protein denotes TNFα protein
T10609 23836-23839 Protein denotes Fig
T10610 23841-23844 Protein denotes S6A
T10611 23864-23873 Protein denotes TNFα mRNA
T10617 23881-23890 Positive_regulation denotes increased
T10616 23881-23890 Positive_regulation denotes increased
T10612 23929-23933 Protein denotes RIP1
T10613 23935-23938 Protein denotes Fig
T10618 23940-23943 Protein denotes S6C
T10619 23974-23978 Protein denotes bFGF
T10624 23985-23994 Negative_regulation denotes triggered
T10623 24000-24009 Positive_regulation denotes induction
T10620 24013-24022 Protein denotes TNFα mRNA
T10621 24051-24059 Protein denotes zVAD.fmk
T10622 24069-24077 Protein denotes zVAD.fmk
T10625 24145-24149 Protein denotes PDGF
T10633 24150-24156 Positive_regulation denotes caused
T10630 24166-24178 Positive_regulation denotes upregulation
T10626 24182-24191 Protein denotes TNFα mRNA
T10631 24215-24224 Positive_regulation denotes increased
T10627 24244-24252 Protein denotes zVAD.fmk
T10628 24254-24261 Protein denotes Fig. 6A
T10634 24349-24357 Positive_regulation denotes increase
T10629 24361-24375 Protein denotes autocrine TNFα
T10632 24376-24385 Gene_expression denotes synthesis
T30916 24431-24434 Protein denotes Akt
T30917 24439-24445 Protein denotes mTORC1
T30925 24446-24453 Regulation denotes control
T30924 24446-24453 Regulation denotes control
T30923 24446-24453 Regulation denotes control
T30927 24446-24453 Regulation denotes control
T30926 24446-24453 Regulation denotes control
T30918 24464-24468 Protein denotes TNFα
T30920 24469-24478 Gene_expression denotes synthesis
T30919 24483-24486 Protein denotes JNK
T30922 24487-24497 Positive_regulation denotes activation
T30921 24487-24497 Positive_regulation denotes activation
T30928 24574-24578 Protein denotes bFGF
T30929 24582-24586 Protein denotes PDGF
T30930 24654-24659 Protein denotes mTNFα
T30931 24684-24697 Protein denotes mouse 18S RNA
T30932 24730-24738 Protein denotes zVAD.fmk
T30933 24742-24746 Protein denotes TNFα
T30934 24769-24774 Protein denotes Nec-1
T30935 24797-24804 Protein denotes Akt inh
T30936 24811-24814 Protein denotes inh
T30937 24848-24857 Protein denotes TNFα mRNA
T30941 24894-24903 Negative_regulation denotes knockdown
T30938 24907-24910 Protein denotes Akt
T30939 24961-24969 Protein denotes zVAD.fmk
T30940 24973-24977 Protein denotes TNFα
T10635 25131-25134 Protein denotes Akt
T10636 25139-25145 Protein denotes mTORC1
T10646 25146-25156 Positive_regulation denotes contribute
T10645 25146-25156 Positive_regulation denotes contribute
T10640 25164-25176 Positive_regulation denotes upregulation
T10637 25180-25189 Protein denotes TNFα mRNA
T10648 25232-25242 Negative_regulation denotes inhibition
T10647 25232-25242 Negative_regulation denotes inhibition
T10650 25247-25252 Negative_regulation denotes siRNA
T10649 25247-25252 Negative_regulation denotes siRNA
T10641 25247-25252 Negative_regulation denotes siRNA
T10643 25253-25262 Negative_regulation denotes knockdown
T10642 25253-25262 Negative_regulation denotes knockdown
T10638 25266-25269 Protein denotes Akt
T10639 25274-25296 Protein denotes mTOR reduced TNFα mRNA
T10644 25297-25303 Positive_regulation denotes levels
T10651 25349-25353 Protein denotes RIP1
T10652 25358-25361 Protein denotes Akt
T10657 25362-25372 Negative_regulation denotes inhibitors
T10656 25362-25372 Negative_regulation denotes inhibitors
T10659 25380-25386 Regulation denotes effect
T10658 25380-25386 Regulation denotes effect
T10653 25404-25413 Protein denotes TNFα mRNA
T10654 25463-25467 Protein denotes bFGF
T10661 25570-25578 Positive_regulation denotes increase
T10655 25582-25586 Protein denotes TNFα
T10660 25587-25596 Gene_expression denotes synthesis
T12495 25599-25602 Protein denotes Akt
T12496 25607-25613 Protein denotes mTORC1
T12503 25614-25621 Regulation denotes Control
T12502 25614-25621 Regulation denotes Control
T12501 25614-25621 Regulation denotes Control
T12500 25614-25621 Regulation denotes Control
T12498 25626-25636 Positive_regulation denotes Activation
T12497 25640-25643 Protein denotes JNK
T12499 25651-25662 Entity denotes Necroptosis
T12504 25663-25666 Protein denotes JNK
T12507 25689-25698 Regulation denotes regulator
T12505 25702-25706 Protein denotes TNFα
T12506 25707-25716 Gene_expression denotes synthesis
T12508 25791-25794 Protein denotes Akt
T12509 25799-25805 Protein denotes mTORC1
T12514 25820-25825 Negative_regulation denotes block
T12512 25830-25838 Positive_regulation denotes increase
T12510 25842-25851 Protein denotes TNFα mRNA
T12515 25877-25881 Regulation denotes role
T12513 25889-25899 Positive_regulation denotes activation
T12511 25903-25906 Protein denotes JNK
T12516 25940-25943 Protein denotes Akt
T12517 25953-25957 Protein denotes Akt1
T12518 25962-25966 Protein denotes Akt2
T12519 25984-25987 Protein denotes Akt
T12527 26037-26045 Positive_regulation denotes increase
T12520 26049-26052 Protein denotes JNK
T12521 26057-26062 Protein denotes c-Jun
T12525 26063-26078 Phosphorylation denotes phosphorylation
T12522 26112-26115 Protein denotes Akt
T12523 26143-26147 Protein denotes RIP1
T12524 26152-26155 Protein denotes JNK
T12526 26156-26166 Positive_regulation denotes activation
T12534 26181-26191 Negative_regulation denotes inhibition
T12528 26195-26198 Protein denotes Akt
T12535 26246-26254 Positive_regulation denotes increase
T12529 26258-26271 Protein denotes bFGF/zVAD.fmk
T12539 26272-26279 Positive_regulation denotes induced
T12538 26272-26279 Positive_regulation denotes induced
T12530 26280-26283 Protein denotes JNK
T12531 26288-26293 Protein denotes c-Jun
T12537 26294-26309 Phosphorylation denotes phosphorylation
T12536 26294-26309 Phosphorylation denotes phosphorylation
T12532 26311-26314 Protein denotes Fig
T12533 26316-26319 Protein denotes S6F
T12544 26322-26331 Negative_regulation denotes Knockdown
T12540 26335-26339 Protein denotes mTOR
T12541 26359-26365 Protein denotes p70S6K
T12546 26366-26375 Negative_regulation denotes inhibitor
T12545 26366-26375 Negative_regulation denotes inhibitor
T12552 26392-26402 Negative_regulation denotes attenuated
T12551 26392-26402 Negative_regulation denotes attenuated
T12550 26430-26438 Positive_regulation denotes increase
T12549 26430-26438 Positive_regulation denotes increase
T12542 26442-26445 Protein denotes JNK
T12543 26450-26455 Protein denotes c-Jun
T12548 26456-26471 Phosphorylation denotes phosphorylation
T12547 26456-26471 Phosphorylation denotes phosphorylation
T12553 26539-26542 Protein denotes Akt
T12554 26543-26549 Protein denotes mTORC1
T12555 26550-26553 Protein denotes S6K
T12556 26583-26594 Protein denotes RIP1 kinase
T12559 26599-26607 Positive_regulation denotes required
T12558 26616-26624 Positive_regulation denotes increase
T12557 26628-26631 Protein denotes JNK
T13265 26676-26686 Protein denotes PI3-kinase
T13266 26691-26695 Protein denotes PDK1
T13272 26784-26794 Regulation denotes regulation
T13267 26798-26801 Protein denotes Akt
T13274 26894-26901 Binding denotes binding
T13268 26909-26928 Protein denotes pleckstrin homology
T13269 26930-26932 Protein denotes PH
T13273 26934-26940 Entity denotes domain
T13270 26944-26947 Protein denotes Akt
T13271 26966-26970 Protein denotes PI3K
T13275 27037-27040 Protein denotes Akt
T13282 27044-27058 Phosphorylation denotes phosphorylated
T13281 27044-27058 Phosphorylation denotes phosphorylated
T13280 27044-27058 Phosphorylation denotes phosphorylated
T13279 27044-27058 Phosphorylation denotes phosphorylated
T13276 27112-27128 Protein denotes protein kinase-1
T13277 27130-27134 Protein denotes PDK1
T13278 27140-27146 Protein denotes mTORC2
T13283 27214-27224 Protein denotes Thr308 Akt
T13286 27225-27240 Phosphorylation denotes phosphorylation
T13287 27244-27253 Positive_regulation denotes increased
T13289 27311-27320 Positive_regulation denotes dependent
T13288 27311-27320 Positive_regulation denotes dependent
T13284 27324-27328 Protein denotes PI3K
T13285 27333-27337 Protein denotes PDK1
T13296 27339-27349 Negative_regulation denotes Inhibition
T13295 27339-27349 Negative_regulation denotes Inhibition
T13290 27353-27357 Protein denotes PI3K
T13291 27362-27366 Protein denotes PDK1
T13302 27447-27457 Negative_regulation denotes inhibition
T13301 27447-27457 Negative_regulation denotes inhibition
T13300 27447-27457 Negative_regulation denotes inhibition
T13292 27476-27486 Protein denotes Akt Thr308
T13299 27487-27502 Phosphorylation denotes phosphorylation
T13298 27487-27502 Phosphorylation denotes phosphorylation
T13297 27487-27502 Phosphorylation denotes phosphorylation
T13293 27504-27507 Protein denotes Fig
T13294 27509-27514 Protein denotes S7A–D
T13307 27533-27542 Negative_regulation denotes knockdown
T13303 27546-27550 Protein denotes PDK1
T13311 27582-27591 Negative_regulation denotes inhibited
T13304 27592-27602 Protein denotes Akt Thr308
T13308 27603-27618 Phosphorylation denotes phosphorylation
T13305 27643-27647 Protein denotes PI3K
T13306 27652-27656 Protein denotes PDK1
T13310 27675-27683 Positive_regulation denotes required
T13309 27675-27683 Positive_regulation denotes required
T15301 27853-27863 Gene_expression denotes expressing
T15300 27853-27863 Gene_expression denotes expressing
T15299 27853-27863 Gene_expression denotes expressing
T15303 27879-27885 Positive_regulation denotes active
T15302 27879-27885 Positive_regulation denotes active
T15294 27886-27900 Protein denotes wild type Akt1
T15295 27902-27905 Protein denotes Myr
T15296 27906-27909 Protein denotes Akt
T15305 27989-28001 Positive_regulation denotes contribution
T15297 28024-28035 Protein denotes RIP1 kinase
T15298 28039-28042 Protein denotes Akt
T15304 28043-28053 Positive_regulation denotes activation
T15310 28089-28095 Positive_regulation denotes active
T15309 28089-28095 Positive_regulation denotes active
T15306 28096-28100 Protein denotes Akt1
T15307 28102-28105 Protein denotes Myr
T15308 28106-28109 Protein denotes Akt
T15311 28225-28237 Localization denotes localization
T15315 28416-28426 Gene_expression denotes expressing
T15314 28416-28426 Gene_expression denotes expressing
T15312 28427-28430 Protein denotes Myr
T15313 28431-28434 Protein denotes Akt
T15316 28623-28626 Protein denotes Akt
T15317 28805-28810 Protein denotes Nec-1
T15323 28811-28820 Negative_regulation denotes prevented
T15318 28826-28829 Protein denotes Myr
T15319 28830-28833 Protein denotes Akt
T15322 28892-28900 Positive_regulation denotes increase
T15320 28904-28907 Protein denotes Akt
T15321 28915-28930 Phosphorylation denotes phosphorylation
T15324 28944-28947 Protein denotes Myr
T15325 28948-28951 Protein denotes Akt
T15334 29008-29018 Positive_regulation denotes activation
T15331 29008-29018 Positive_regulation denotes activation
T15326 29022-29025 Protein denotes JNK
T15327 29030-29035 Protein denotes c-Jun
T15332 29036-29051 Phosphorylation denotes phosphorylation
T15333 29066-29078 Positive_regulation denotes upregulation
T15328 29082-29091 Protein denotes TNFα mRNA
T15329 29093-29096 Protein denotes Fig
T15330 29173-29176 Protein denotes Akt
T15335 29290-29293 Protein denotes Akt
T15338 29311-29319 Positive_regulation denotes uncouple
T15336 29320-29323 Protein denotes Akt
T15337 29324-29334 Positive_regulation denotes activation
T15339 29384-29395 Protein denotes RIP1 kinase
T15343 29414-29422 Regulation denotes regulate
T15340 29423-29426 Protein denotes Akt
T15342 29427-29437 Positive_regulation denotes activation
T15341 29493-29504 Protein denotes RIP1 kinase
T31705 29805-29812 Protein denotes Myr-Akt
T31706 29843-29856 Protein denotes Myr-Akt K179M
T31707 30041-30044 Protein denotes Myr
T31708 30045-30048 Protein denotes Akt
T31709 30053-30056 Protein denotes Myr
T31710 30057-30060 Protein denotes Akt
T31711 30091-30099 Protein denotes zVAD.fmk
T31712 30231-30234 Protein denotes Myr
T31713 30235-30238 Protein denotes Akt
T31714 30301-30308 Protein denotes Myr-Akt
T31715 30313-30327 Protein denotes Myr-Akt K179KM
T31716 30350-30358 Protein denotes zVAD.fmk
T31717 30397-30406 Protein denotes TNFα mRNA
T31718 30462-30475 Protein denotes mouse 18S RNA
T31721 30494-30504 Gene_expression denotes expressing
T31719 30505-30512 Protein denotes Myr-Akt
T31720 30699-30708 Protein denotes TNFα mRNA
T15345 30828-30835 Protein denotes Myr-Akt
T15352 30855-30864 Positive_regulation denotes increased
T15351 30855-30864 Positive_regulation denotes increased
T15346 30865-30868 Protein denotes Myr
T15347 30869-30872 Protein denotes Akt
T15348 30908-30911 Protein denotes Akt
T15349 30913-30916 Protein denotes Fig
T15358 30922-30937 Phosphorylation denotes Phosphorylation
T15354 30967-30970 Protein denotes Akt
T15359 30986-30995 Positive_regulation denotes increased
T15361 31005-31015 Gene_expression denotes expression
T15360 31005-31015 Gene_expression denotes expression
T15355 31019-31022 Protein denotes Myr
T15356 31023-31026 Protein denotes Akt
T15357 31090-31093 Protein denotes Akt
T15363 31204-31213 Positive_regulation denotes increased
T15362 31232-31239 Protein denotes Myr-Akt
T15364 31268-31274 Protein denotes p70S6K
T15365 31276-31278 Protein denotes S6
T15366 31280-31285 Protein denotes GSK-3
T15367 31290-31295 Protein denotes FoxO4
T15371 31308-31322 Phosphorylation denotes phosphorylated
T15370 31308-31322 Phosphorylation denotes phosphorylated
T15369 31308-31322 Phosphorylation denotes phosphorylated
T15368 31308-31322 Phosphorylation denotes phosphorylated
T15377 31375-31390 Phosphorylation denotes phosphorylation
T15376 31375-31390 Phosphorylation denotes phosphorylation
T15372 31394-31399 Protein denotes FoxO1
T15373 31404-31408 Protein denotes MDM2
T15378 31427-31436 Positive_regulation denotes increased
T15379 31427-31436 Positive_regulation denotes increased
T15380 31482-31493 Entity denotes necroptotic
T15382 31501-31516 Phosphorylation denotes phosphorylation
T15381 31501-31516 Phosphorylation denotes phosphorylation
T15374 31520-31523 Protein denotes Myr
T15375 31524-31527 Protein denotes Akt
T15383 31637-31640 Protein denotes JNK
T15391 31641-31651 Positive_regulation denotes activation
T15387 31641-31651 Positive_regulation denotes activation
T15384 31653-31657 Protein denotes TNFα
T15388 31658-31668 Gene_expression denotes production
T15390 31697-31706 Gene_expression denotes expressed
T15389 31697-31706 Gene_expression denotes expressed
T15385 31707-31710 Protein denotes Myr
T15386 31711-31714 Protein denotes Akt
T15393 31824-31836 Localization denotes localization
T15392 31840-31843 Protein denotes Akt
T15394 31857-31872 Protein denotes Full length Akt
T15399 31885-31892 Negative_regulation denotes lacking
T15398 31885-31892 Negative_regulation denotes lacking
T15395 31902-31911 Protein denotes PH domain
T15396 31920-31927 Protein denotes Myr tag
T15401 31976-31985 Positive_regulation denotes increased
T15397 31986-31992 Protein denotes Thr308
T15400 31993-32008 Phosphorylation denotes phosphorylation
T15406 32120-32124 Regulation denotes role
T15402 32129-32135 Protein denotes Thr308
T15404 32136-32151 Phosphorylation denotes phosphorylation
T15405 32159-32169 Regulation denotes regulation
T15403 32202-32205 Protein denotes Akt
T15409 32276-32285 Negative_regulation denotes reduction
T15407 32315-32318 Protein denotes Akt
T15408 32326-32337 Protein denotes Asp mutants
T15411 32378-32384 Regulation denotes effect
T15410 32396-32407 Protein denotes Asp mutants
T15412 32461-32472 Protein denotes Asp mutants
T15413 32532-32543 Protein denotes Ala mutants
T15414 32565-32574 Negative_regulation denotes decreases
T15415 32637-32643 Protein denotes Thr308
T15416 32648-32662 Protein denotes Ser473 mutants
T15419 32998-33012 Phosphorylation denotes phosphorylated
T15417 33016-33022 Protein denotes Thr308
T15420 33087-33101 Phosphorylation denotes phosphorylated
T15418 33133-33137 Protein denotes PDK1
T15428 33249-33258 Positive_regulation denotes promoting
T15427 33249-33258 Positive_regulation denotes promoting
T15424 33249-33258 Positive_regulation denotes promoting
T15426 33271-33286 Phosphorylation denotes phosphorylation
T15425 33271-33286 Phosphorylation denotes phosphorylation
T15421 33290-33293 Protein denotes JNK
T15422 33298-33303 Protein denotes c-Jun
T15423 33309-33318 Protein denotes TNFα mRNA
T15429 33374-33377 Protein denotes Akt
T15430 33419-33434 Phosphorylation denotes phosphorylation
T15442 33668-33682 Phosphorylation denotes phosphorylated
T15441 33668-33682 Phosphorylation denotes phosphorylated
T15440 33668-33682 Phosphorylation denotes phosphorylated
T15439 33668-33682 Phosphorylation denotes phosphorylated
T15431 33690-33693 Protein denotes Myr
T15432 33694-33697 Protein denotes Akt
T15433 33727-33747 Protein denotes zVAD including FoxO1
T15434 33749-33754 Protein denotes Foxo4
T15435 33756-33760 Protein denotes MDM2
T15436 33766-33772 Protein denotes p70S6K
T15437 33774-33777 Protein denotes Fig
T15438 33779-33782 Protein denotes S8D
T15443 33931-33941 Protein denotes Akt kinase
T15444 33952-33955 Protein denotes Akt
T15445 34012-34016 Protein denotes TNFα
T15447 34017-34026 Gene_expression denotes synthesis
T15446 34028-34031 Protein denotes JNK
T15449 34032-34042 Positive_regulation denotes activation
T15448 34032-34042 Positive_regulation denotes activation
T17907 34069-34086 Protein denotes Akt Controls TNFα
T17908 34087-34097 Gene_expression denotes Production
T17909 34149-34160 Protein denotes RIP1 kinase
T17910 34184-34187 Protein denotes Akt
T17911 34303-34306 Protein denotes Fas
T17912 34509-34513 Protein denotes TNFα
T17913 34517-34525 Protein denotes zVAD.fmk
T17914 34571-34582 Protein denotes RIP1 kinase
T17915 34718-34727 Protein denotes TNFα mRNA
T17918 34740-34749 Positive_regulation denotes increased
T17922 34813-34822 Negative_regulation denotes inhibited
T17921 34813-34822 Negative_regulation denotes inhibited
T17916 34831-34835 Protein denotes RIP1
T17917 34840-34843 Protein denotes Akt
T17920 34844-34854 Negative_regulation denotes inhibitors
T17919 34844-34854 Negative_regulation denotes inhibitors
T17926 34879-34889 Negative_regulation denotes inhibition
T17923 34893-34896 Protein denotes Akt
T17924 34937-34940 Protein denotes Fig
T17925 34942-34945 Protein denotes S9A
T17931 34980-34990 Regulation denotes regulation
T17927 34994-35008 Protein denotes autocrine TNFα
T17930 35009-35018 Gene_expression denotes synthesis
T17928 35105-35108 Protein denotes Akt
T17929 35131-35142 Protein denotes RIP1 kinase
T32194 35254-35257 Protein denotes Akt
T32195 35283-35297 Protein denotes autocrine TNFα
T32196 35298-35308 Gene_expression denotes production
T32197 35379-35383 Protein denotes TNFα
T32198 35421-35430 Protein denotes TNFα mRNA
T32199 35470-35483 Protein denotes human 18S RNA
T32200 35631-35640 Protein denotes TNFα mRNA
T32205 35726-35736 Gene_expression denotes expressing
T32201 35737-35744 Protein denotes Myr-Akt
T32202 35772-35780 Protein denotes zVAD.fmk
T32203 35785-35789 Protein denotes TNFα
T32204 35817-35826 Protein denotes TNFα mRNA
T32212 35881-35891 Gene_expression denotes expressing
T32211 35881-35891 Gene_expression denotes expressing
T32206 35908-35912 Protein denotes Akt1
T32207 35916-35920 Protein denotes Akt2
T32208 35939-35947 Protein denotes zVAD.fmk
T32209 35952-35956 Protein denotes TNFα
T32210 35984-35993 Protein denotes TNFα mRNA
T17932 36058-36061 Protein denotes Akt
T17933 36169-36172 Protein denotes Akt
T17934 36243-36247 Protein denotes TNFα
T17935 36252-36260 Protein denotes zVAD.fmk
T17947 36262-36272 Gene_expression denotes Expression
T17946 36262-36272 Gene_expression denotes Expression
T17945 36262-36272 Gene_expression denotes Expression
T17936 36297-36300 Protein denotes Akt
T17937 36302-36305 Protein denotes Myr
T17938 36306-36309 Protein denotes Akt
T17939 36335-36344 Protein denotes TNFα mRNA
T17948 36345-36355 Gene_expression denotes production
T17940 36371-36375 Protein denotes TNFα
T17941 36380-36388 Protein denotes zVAD.fmk
T17942 36390-36397 Protein denotes Fig. 8G
T17943 36435-36438 Protein denotes Fig
T17944 36440-36443 Protein denotes S9D
T17959 36511-36521 Gene_expression denotes expressing
T17958 36511-36521 Gene_expression denotes expressing
T17949 36522-36537 Protein denotes endogenous Akt1
T17950 36541-36545 Protein denotes Akt2
T17964 36551-36565 Phosphorylation denotes phosphorylated
T17963 36551-36565 Phosphorylation denotes phosphorylated
T17962 36551-36565 Phosphorylation denotes phosphorylated
T17961 36551-36565 Phosphorylation denotes phosphorylated
T17960 36551-36565 Phosphorylation denotes phosphorylated
T17951 36569-36575 Protein denotes Thr308
T17952 36591-36595 Protein denotes TNFα
T17953 36600-36608 Protein denotes zVAD.fmk
T17954 36610-36613 Protein denotes Fig
T17955 36615-36618 Protein denotes S9E
T17956 36645-36649 Protein denotes RIP1
T17957 36660-36669 Protein denotes TNFα mRNA
T17965 36670-36682 Positive_regulation denotes upregulation
T17966 36775-36778 Protein denotes Akt
T17967 36804-36818 Protein denotes autocrine TNFα
T17968 36819-36828 Gene_expression denotes synthesis
T19543 37015-37020 Gene_expression denotes Model
T19542 37015-37020 Gene_expression denotes Model
T19541 37015-37020 Gene_expression denotes Model
T19538 37024-37028 Protein denotes RIP1
T19539 37030-37033 Protein denotes Akt
T19540 37038-37041 Protein denotes JNK
T19544 37118-37129 Protein denotes RIP1 kinase
T19545 37245-37252 Protein denotes caspase
T19546 37310-37320 Protein denotes Akt kinase
T19548 37337-37344 Binding denotes engaged
T19547 37374-37385 Protein denotes RIP1 kinase
T19549 37393-37398 Binding denotes leads
T19551 37529-37544 Phosphorylation denotes phosphorylation
T19550 37548-37551 Protein denotes Akt
T19552 37552-37560 Positive_regulation denotes requires
T19554 37665-37677 Localization denotes localization
T19553 37681-37684 Protein denotes Akt
T19558 37686-37696 Gene_expression denotes Expression
T19557 37686-37696 Gene_expression denotes Expression
T19555 37735-37738 Protein denotes Akt
T19556 37750-37757 Protein denotes Myr-Akt
T19562 37823-37833 Gene_expression denotes expression
T19561 37823-37833 Gene_expression denotes expression
T19559 37837-37840 Protein denotes Myr
T19560 37841-37844 Protein denotes Akt
T19564 37858-37868 Positive_regulation denotes sufficient
T19563 37858-37868 Positive_regulation denotes sufficient
T19565 37913-37924 Protein denotes RIP1 kinase
T19573 37944-37952 Positive_regulation denotes required
T19572 37944-37952 Positive_regulation denotes required
T19566 37957-37963 Protein denotes Thr308
T19570 37964-37979 Phosphorylation denotes phosphorylation
T19569 37964-37979 Phosphorylation denotes phosphorylation
T19567 37983-37986 Protein denotes Akt
T19568 38002-38009 Protein denotes caspase
T19571 38010-38020 Negative_regulation denotes inhibition
T32440 38138-38142 Protein denotes RIP1
T32441 38144-38147 Protein denotes Akt
T32442 38152-38155 Protein denotes JNK
T32443 38203-38206 Protein denotes Akt
T32445 38207-38222 Phosphorylation denotes phosphorylation
T32446 38252-38260 Positive_regulation denotes requires
T32444 38297-38308 Protein denotes RIP1 kinase
T32447 38326-38329 Protein denotes Akt
T32448 38331-38334 Protein denotes JNK
T32450 38335-38345 Positive_regulation denotes activation
T32449 38355-38359 Protein denotes TNFα
T32451 38360-38369 Gene_expression denotes synthesis
T32455 38371-38381 Positive_regulation denotes Activation
T32452 38385-38388 Protein denotes Akt
T32459 38413-38418 Positive_regulation denotes leads
T32458 38413-38418 Positive_regulation denotes leads
T32457 38423-38438 Phosphorylation denotes phosphorylation
T32456 38423-38438 Phosphorylation denotes phosphorylation
T32453 38456-38459 Protein denotes Akt
T32454 38480-38484 Protein denotes mTOR
T19584 38556-38561 Negative_regulation denotes Using
T19583 38556-38561 Negative_regulation denotes Using
T19582 38556-38561 Negative_regulation denotes Using
T19574 38562-38565 Protein denotes Akt
T19585 38566-38576 Negative_regulation denotes inhibitors
T19578 38566-38576 Negative_regulation denotes inhibitors
T19579 38578-38587 Negative_regulation denotes knockdown
T19575 38591-38594 Protein denotes Akt
T19580 38613-38623 Gene_expression denotes expression
T19576 38627-38638 Protein denotes Akt mutants
T19581 38667-38677 Positive_regulation denotes activation
T19577 38681-38684 Protein denotes Akt
T19590 38882-38897 Phosphorylation denotes phosphorylation
T19589 38882-38897 Phosphorylation denotes phosphorylation
T19586 38901-38907 Protein denotes Thr308
T19587 38911-38914 Protein denotes Akt
T19588 39029-39035 Protein denotes mTORC1
T19591 39120-39123 Protein denotes Akt
T19595 39124-39134 Positive_regulation denotes activation
T19598 39159-39169 Positive_regulation denotes connecting
T19592 39170-39181 Protein denotes RIP1 kinase
T19593 39268-39271 Protein denotes JNK
T19599 39272-39282 Positive_regulation denotes activation
T19596 39272-39282 Positive_regulation denotes activation
T19594 39287-39301 Protein denotes autocrine TNFα
T19597 39302-39311 Gene_expression denotes synthesis
T19604 39404-39412 Positive_regulation denotes examined
T19600 39413-39416 Protein denotes Akt
T19602 39417-39432 Phosphorylation denotes phosphorylation
T19603 39439-39449 Negative_regulation denotes inhibition
T19601 39489-39492 Protein denotes JNK
T19607 39617-39626 Negative_regulation denotes inhibited
T19606 39657-39672 Phosphorylation denotes phosphorylation
T19605 39683-39686 Protein denotes Akt
T19608 39820-39825 Protein denotes p110δ
T19609 39837-39855 Protein denotes PI3K [41] and PDK1
T19611 39901-39908 Negative_regulation denotes inhibit
T19613 39901-39908 Negative_regulation denotes inhibit
T19610 39915-39918 Protein denotes Akt
T19612 39919-39934 Phosphorylation denotes phosphorylation
T19614 40024-40027 Protein denotes JNK
T19615 40060-40063 Protein denotes JNK
T19621 40064-40073 Negative_regulation denotes inhibitor
T19616 40075-40078 Protein denotes JNK
T19617 40119-40123 Protein denotes JNK1
T19618 40128-40132 Protein denotes JNK2
T19619 40134-40137 Protein denotes Fig
T19620 40139-40145 Protein denotes S10B–G
T19625 40170-40180 Negative_regulation denotes inhibition
T19622 40197-40201 Protein denotes JNK1
T19626 40212-40227 Phosphorylation denotes phosphorylation
T19623 40231-40234 Protein denotes Akt
T19628 40251-40261 Negative_regulation denotes inhibiting
T19627 40266-40281 Phosphorylation denotes phosphorylation
T19624 40285-40290 Protein denotes c-Jun
T19632 40371-40380 Negative_regulation denotes reduction
T19629 40384-40388 Protein denotes TNFα
T19631 40389-40399 Gene_expression denotes production
T19630 40559-40562 Protein denotes JNK
T19638 40618-40622 Regulation denotes role
T19633 40627-40632 Protein denotes c-Jun
T19634 40652-40666 Protein denotes autocrine TNFα
T19636 40667-40676 Gene_expression denotes synthesis
T19635 40735-40746 Protein denotes c-Jun siRNA
T19637 40747-40756 Negative_regulation denotes knockdown
T19639 40872-40886 Protein denotes autocrine TNFα
T19642 40887-40897 Gene_expression denotes production
T19643 40899-40908 Positive_regulation denotes dependent
T19640 40912-40917 Protein denotes c-Jun
T19644 40978-40988 Positive_regulation denotes activation
T19641 40992-40995 Protein denotes Akt
T19651 41054-41062 Positive_regulation denotes increase
T19650 41054-41062 Positive_regulation denotes increase
T19645 41087-41092 Protein denotes c-Jun
T19646 41128-41136 Protein denotes zVAD.fmk
T19647 41140-41144 Protein denotes TNFα
T19648 41161-41164 Protein denotes Akt
T19649 41169-41173 Protein denotes mTOR
T19652 41267-41272 Protein denotes c-Jun
T19653 41308-41311 Protein denotes JNK
T19655 41407-41422 Phosphorylation denotes phosphorylation
T19654 41426-41431 Protein denotes c-Jun
T23147 41655-41665 Protein denotes Akt kinase
T23151 41682-41689 Binding denotes engaged
T23148 41723-41734 Protein denotes RIP1 kinase
T23155 41792-41800 Positive_regulation denotes increase
T23154 41792-41800 Positive_regulation denotes increase
T23149 41804-41807 Protein denotes Akt
T23153 41808-41823 Phosphorylation denotes phosphorylation
T23152 41808-41823 Phosphorylation denotes phosphorylation
T23150 41827-41833 Protein denotes Thr308
T23159 41856-41866 Positive_regulation denotes connecting
T23156 41867-41878 Protein denotes RIP1 kinase
T23157 41968-41971 Protein denotes JNK
T23162 41972-41982 Positive_regulation denotes activation
T23160 41972-41982 Positive_regulation denotes activation
T23158 41984-41998 Protein denotes autocrine TNFα
T23161 41999-42008 Gene_expression denotes synthesis
T23164 42058-42073 Phosphorylation denotes phosphorylation
T23163 42077-42080 Protein denotes Akt
T23165 42081-42089 Positive_regulation denotes requires
T23167 42194-42206 Localization denotes localization
T23166 42210-42213 Protein denotes Akt
T23171 42215-42225 Gene_expression denotes Expression
T23170 42215-42225 Gene_expression denotes Expression
T23168 42269-42272 Protein denotes Myr
T23169 42273-42276 Protein denotes Akt
T23177 42323-42333 Gene_expression denotes expression
T23176 42323-42333 Gene_expression denotes expression
T23172 42337-42340 Protein denotes Myr
T23173 42341-42344 Protein denotes Akt
T23181 42352-42362 Positive_regulation denotes sufficient
T23183 42409-42419 Positive_regulation denotes activation
T23182 42409-42419 Positive_regulation denotes activation
T23178 42409-42419 Positive_regulation denotes activation
T23174 42423-42426 Protein denotes JNK
T23175 42431-42435 Protein denotes TNFα
T23180 42436-42445 Gene_expression denotes synthesis
T23179 42436-42445 Gene_expression denotes synthesis
T23184 42457-42468 Protein denotes RIP1 kinase
T23190 42488-42496 Positive_regulation denotes required
T23189 42488-42496 Positive_regulation denotes required
T23185 42501-42507 Protein denotes Thr308
T23188 42508-42523 Phosphorylation denotes phosphorylation
T23187 42508-42523 Phosphorylation denotes phosphorylation
T23186 42527-42530 Protein denotes Akt
T23195 42597-42612 Phosphorylation denotes phosphorylation
T23194 42597-42612 Phosphorylation denotes phosphorylation
T23191 42616-42622 Protein denotes Thr308
T23192 42626-42629 Protein denotes Akt
T23193 42784-42790 Protein denotes mTORC1
T23197 42962-42972 Regulation denotes regulation
T23196 42976-42979 Protein denotes Akt
T23198 43036-43040 Protein denotes RIP1
T23202 43041-43050 Regulation denotes dependent
T23201 43051-43059 Positive_regulation denotes increase
T23199 43063-43066 Protein denotes Akt
T23200 43074-43089 Phosphorylation denotes phosphorylation
T23203 43115-43126 Protein denotes RIP1 kinase
T23205 43155-43162 Regulation denotes targets
T23204 43163-43169 Protein denotes Thr308
T23206 43189-43193 Protein denotes PP2A
T23213 43308-43314 Regulation denotes effect
T23212 43308-43314 Regulation denotes effect
T23207 43322-43326 Protein denotes PP2A
T23209 43327-43336 Negative_regulation denotes inhibitor
T23208 43355-43361 Protein denotes Thr308
T23210 43362-43377 Phosphorylation denotes phosphorylation
T23211 43381-43391 Positive_regulation denotes activation
T23214 43486-43497 Protein denotes RIP1 kinase
T23215 43508-43512 Protein denotes PDK1
T23216 43514-43517 Protein denotes Akt
T23220 43607-43622 Phosphorylation denotes phosphorylation
T23219 43607-43622 Phosphorylation denotes phosphorylation
T23217 43626-43629 Protein denotes Akt
T23218 43633-43656 Protein denotes recombinant RIP1 kinase
T23221 43762-43765 Protein denotes Myr
T23222 43766-43769 Protein denotes Akt
T23226 44068-44083 Phosphorylation denotes phosphorylation
T23225 44068-44083 Phosphorylation denotes phosphorylation
T23223 44087-44090 Protein denotes Akt
T23224 44094-44098 Protein denotes RIP1
T23228 44170-44180 Regulation denotes regulation
T23227 44170-44180 Regulation denotes regulation
T23229 44221-44224 Protein denotes Akt
T23230 44257-44261 Protein denotes TNFα
T23231 44262-44271 Gene_expression denotes synthesis
T23232 44321-44324 Protein denotes Akt
T23233 44445-44451 Protein denotes mTORC1
T23234 44750-44753 Protein denotes JNK
T23236 44836-44846 Regulation denotes regulation
T23235 44850-44853 Protein denotes JNK
T23243 44962-44972 Positive_regulation denotes activation
T23237 44976-44979 Protein denotes JNK
T23238 44983-44987 Protein denotes TNFα
T23239 45010-45016 Protein denotes mTORC1
T23244 45041-45048 Regulation denotes control
T23240 45089-45095 Protein denotes mTORC1
T23241 45130-45134 Protein denotes TNFα
T23242 45179-45182 Protein denotes JNK
T23245 45184-45187 Protein denotes Akt
T23249 45435-45445 Regulation denotes regulation
T23248 45435-45445 Regulation denotes regulation
T23246 45449-45452 Protein denotes Akt
T23247 45456-45467 Protein denotes RIP1 kinase
T23250 45540-45543 Protein denotes Akt
T23251 45635-45641 Protein denotes mTORC1
T23252 45680-45684 Protein denotes MDM2
T23254 45737-45747 Positive_regulation denotes activation
T23253 45751-45754 Protein denotes Akt
T23255 45943-45946 Protein denotes Akt
T23256 46139-46142 Protein denotes Akt
T23257 46185-46196 Protein denotes RIP1 kinase
T23258 46378-46381 Protein denotes Akt
T23259 46396-46399 Protein denotes Akt
T23261 46400-46410 Positive_regulation denotes activation
T23263 46424-46434 Negative_regulation denotes inhibition
T23262 46456-46466 Positive_regulation denotes activation
T23260 46470-46474 Protein denotes mTOR
T23264 46702-46710 Protein denotes zVAD.fmk
T23265 46851-46860 Protein denotes TNFα [49]
T23271 46885-46895 Negative_regulation denotes inhibition
T23270 46885-46895 Negative_regulation denotes inhibition
T23266 46899-46908 Protein denotes autophagy
T23267 46912-46915 Protein denotes Akt
T23268 46919-46923 Protein denotes mTOR
T23269 46979-46983 Protein denotes TNFα
T23272 47294-47297 Protein denotes Akt
T23273 47343-47354 Protein denotes RIP1 kinase
T23274 47368-47371 Protein denotes Akt
T23275 47593-47597 Protein denotes FADD
T23278 47598-47607 Negative_regulation denotes deficient
T23276 47639-47642 Protein denotes Akt
T23280 47688-47696 Positive_regulation denotes increase
T23277 47700-47704 Protein denotes TNFα
T23279 47705-47714 Gene_expression denotes synthesis
T23281 47861-47865 Protein denotes RIP1
T23284 47893-47902 Positive_regulation denotes mediating
T23283 47907-47917 Gene_expression denotes production
T23282 47921-47925 Protein denotes TNFα
T23285 48048-48051 Protein denotes Akt
T23291 48673-48683 Positive_regulation denotes activation
T23289 48673-48683 Positive_regulation denotes activation
T23286 48687-48691 Protein denotes TNFα
T23290 48692-48701 Gene_expression denotes synthesis
T23287 48705-48709 Protein denotes RIP1
T23288 48710-48713 Protein denotes Akt
T23299 48936-48943 Regulation denotes control
T23298 48936-48943 Regulation denotes control
T23297 48936-48943 Regulation denotes control
T23292 48949-48953 Protein denotes RIP1
T23293 48954-48965 Protein denotes RIP3 kinase
T23294 48980-48984 Protein denotes FADD
T23295 48989-48996 Protein denotes caspase
T23296 49069-49073 Protein denotes TNFα
T23300 49074-49084 Gene_expression denotes production
T23303 49213-49222 Positive_regulation denotes increased
T23302 49223-49233 Gene_expression denotes production
T23301 49237-49241 Protein denotes TNFα
T23304 49582-49586 Protein denotes RIP1
T23305 49591-49595 Protein denotes RIP3
T23306 49638-49641 Protein denotes TNF
T23307 49672-49683 Protein denotes RIP1 kinase
T23308 49785-49796 Protein denotes RIP1 kinase
T23309 49797-49807 Negative_regulation denotes inhibitors
T25532 50116-50119 Protein denotes Akt
T25536 50120-50129 Negative_regulation denotes inhibitor
T25534 50120-50129 Negative_regulation denotes inhibitor
T25533 50266-50269 Protein denotes JNK
T25535 50270-50279 Negative_regulation denotes inhibitor
T25537 50717-50720 Protein denotes Pan
T25538 50721-50728 Protein denotes caspase
T25539 50802-50806 Protein denotes TNFα
T25540 50819-50829 Protein denotes human bFGF
T25541 50842-50845 Protein denotes EGF
T25542 50858-50865 Protein denotes PDGF-BB
T25543 50882-50887 Protein denotes IGF-1
T26089 52211-52221 Protein denotes Mouse TNFα
T26090 52392-52396 Protein denotes TNFα
T26091 52437-52447 Protein denotes human TNFα
T26896 53945-53971 Protein denotes Mouse ribosomal S6 protein
T26903 53973-53984 Entity denotes L-040893-00
T26897 54009-54013 Protein denotes Akt1
T26898 54035-54039 Protein denotes Akt2
T26899 54061-54065 Protein denotes Akt3
T26904 54093-54104 Entity denotes L-065427-00
T26900 54113-54117 Protein denotes PDK1
T26905 54144-54151 Regulation denotes control
T26901 54176-54181 Protein denotes Mapk8
T26902 54203-54208 Protein denotes Mapk9
T26906 54235-54246 Entity denotes L-043776-00
T26907 54390-54406 Protein denotes zVAD.fmk or TNFα
T27327 54617-54628 Protein denotes µM zVAD.fmk
T27328 54647-54651 Protein denotes TNFα
T27329 54776-54787 Protein denotes µM zVAD.fmk
T27330 54806-54810 Protein denotes TNFα
T27331 55299-55312 Protein denotes serum albumin
T27332 55314-55317 Protein denotes BSA
T27687 56007-56029 Protein denotes SYBRGreen 2×Master mix
T27862 56096-56104 Protein denotes Myr-Akt1
T27863 56216-56219 Protein denotes gal
T27864 56220-56223 Protein denotes pol
T28227 57079-57089 Protein denotes TNFα ELISA
T28228 57090-57117 Protein denotes Mouse TNFα Quantikine ELISA
T28381 57287-57297 Protein denotes Akt Kinase
T28382 57304-57314 Protein denotes Akt kinase
T28383 57347-57357 Protein denotes Akt kinase
T28384 57427-57430 Protein denotes Myr
T28385 57431-57434 Protein denotes Akt
T28386 57571-57589 Protein denotes GSK fusion protein
T28388 57601-57616 Phosphorylation denotes Phosphorylation
T28387 57624-57642 Protein denotes GSK fusion protein
R10042 T15294 T15299 themeOf wild type Akt1,expressing
R10043 T15294 T15302 themeOf wild type Akt1,active
R10044 T15295 T15300 themeOf Myr,expressing
R10045 T15296 T15301 themeOf Akt,expressing
R10046 T15296 T15303 themeOf Akt,active
R10047 T15298 T15304 themeOf Akt,activation
R10048 T15304 T15305 themeOf activation,contribution
R10049 T15306 T15309 themeOf Akt1,active
R10050 T15308 T15310 themeOf Akt,active
R10051 T15308 T15311 themeOf Akt,localization
R10052 T15312 T15314 themeOf Myr,expressing
R10053 T15313 T15315 themeOf Akt,expressing
R10054 T15317 T15323 causeOf Nec-1,prevented
R10055 T15320 T15321 themeOf Akt,phosphorylation
R10056 T15321 T15322 themeOf phosphorylation,increase
R10057 T15322 T15323 themeOf increase,prevented
R10058 T15326 T15331 themeOf JNK,activation
R10059 T15327 T15332 themeOf c-Jun,phosphorylation
R10060 T15328 T15333 themeOf TNFα mRNA,upregulation
R10061 T15329 T15333 causeOf Fig,upregulation
R10062 T15332 T15334 themeOf phosphorylation,activation
R10063 T15336 T15337 themeOf Akt,activation
R10064 T15337 T15338 themeOf activation,uncouple
R10065 T15339 T15343 causeOf RIP1 kinase,regulate
R10066 T15340 T15342 themeOf Akt,activation
R10067 T15342 T15343 themeOf activation,regulate
R10068 T15344 T15353 causeOf RIP1 kinase,dependent
R10069 T15345 T15350 themeOf Myr-Akt,phosphorylation
R10070 T15347 T15351 themeOf Akt,increased
R10071 T15347 T15352 themeOf Akt,increased
R10072 T15349 T15351 causeOf Fig,increased
R10073 T15350 T15352 causeOf phosphorylation,increased
R10074 T15350 T15353 themeOf phosphorylation,dependent
R10075 T15354 T15358 themeOf Akt,Phosphorylation
R10076 T15355 T15360 themeOf Myr,expression
R10077 T15356 T15361 themeOf Akt,expression
R10078 T15358 T15359 themeOf Phosphorylation,increased
R10079 T15362 T15363 themeOf Myr-Akt,increased
R10080 T15364 T15368 themeOf p70S6K,phosphorylated
R10081 T15365 T15369 themeOf S6,phosphorylated
R10082 T15366 T15370 themeOf GSK-3,phosphorylated
R10083 T15367 T15371 themeOf FoxO4,phosphorylated
R10084 T15372 T15376 themeOf FoxO1,phosphorylation
R10085 T15373 T15377 themeOf MDM2,phosphorylation
R10086 T15374 T15381 themeOf Myr,phosphorylation
R10087 T15374 T15380 partOf Myr,necroptotic
R10088 T15375 T15382 themeOf Akt,phosphorylation
R10089 T15375 T15380 partOf Akt,necroptotic
R10090 T15376 T15378 themeOf phosphorylation,increased
R10091 T15377 T15379 themeOf phosphorylation,increased
R10092 T15380 T15381 Site necroptotic,phosphorylation
R10093 T15380 T15382 Site necroptotic,phosphorylation
R10094 T15383 T15387 themeOf JNK,activation
R10095 T15384 T15388 themeOf TNFα,production
R10096 T15385 T15389 themeOf Myr,expressed
R10097 T15386 T15390 themeOf Akt,expressed
R10098 T15388 T15391 themeOf production,activation
R10099 T15392 T15393 themeOf Akt,localization
R10100 T15394 T15401 causeOf Full length Akt,increased
R10101 T15395 T15398 themeOf PH domain,lacking
R10102 T15396 T15399 themeOf Myr tag,lacking
R10103 T15397 T15400 themeOf Thr308,phosphorylation
R10104 T15400 T15401 themeOf phosphorylation,increased
R10105 T15402 T15404 themeOf Thr308,phosphorylation
R10106 T15403 T15405 themeOf Akt,regulation
R10107 T15405 T15406 themeOf regulation,role
R10108 T15407 T15409 themeOf Akt,reduction
R10109 T15410 T15411 themeOf Asp mutants,effect
R10110 T15413 T15414 themeOf Ala mutants,decreases
R10111 T15417 T15419 themeOf Thr308,phosphorylated
R10112 T15417 T15420 themeOf Thr308,phosphorylated
R10113 T15421 T15425 themeOf JNK,phosphorylation
R10114 T15422 T15426 themeOf c-Jun,phosphorylation
R10115 T15423 T15424 themeOf TNFα mRNA,promoting
R10116 T15425 T15427 themeOf phosphorylation,promoting
R10117 T15426 T15428 themeOf phosphorylation,promoting
R10118 T15429 T15430 themeOf Akt,phosphorylation
R10119 T15432 T15439 themeOf Akt,phosphorylated
R10120 T15433 T15440 themeOf zVAD including FoxO1,phosphorylated
R10121 T15434 T15441 themeOf Foxo4,phosphorylated
R10122 T15435 T15442 themeOf MDM2,phosphorylated
R10123 T15445 T15447 themeOf TNFα,synthesis
R10124 T15446 T15448 themeOf JNK,activation
R10125 T15447 T15449 themeOf synthesis,activation
R12013 T17907 T17908 themeOf Akt Controls TNFα,Production
R12014 T17915 T17918 themeOf TNFα mRNA,increased
R12015 T17915 T17921 themeOf TNFα mRNA,inhibited
R12016 T17915 T17922 themeOf TNFα mRNA,inhibited
R12017 T17916 T17919 themeOf RIP1,inhibitors
R12018 T17917 T17920 themeOf Akt,inhibitors
R12019 T17919 T17921 causeOf inhibitors,inhibited
R12020 T17920 T17922 causeOf inhibitors,inhibited
R12021 T17923 T17926 themeOf Akt,inhibition
R12022 T17927 T17930 themeOf autocrine TNFα,synthesis
R12023 T17930 T17931 themeOf synthesis,regulation
R12024 T17936 T17945 themeOf Akt,Expression
R12025 T17937 T17946 themeOf Myr,Expression
R12026 T17938 T17947 themeOf Akt,Expression
R12027 T17939 T17948 themeOf TNFα mRNA,production
R12028 T17949 T17958 themeOf endogenous Akt1,expressing
R12029 T17950 T17959 themeOf Akt2,expressing
R12030 T17951 T17960 themeOf Thr308,phosphorylated
R12031 T17952 T17961 themeOf TNFα,phosphorylated
R12032 T17953 T17962 themeOf zVAD.fmk,phosphorylated
R12033 T17954 T17963 themeOf Fig,phosphorylated
R12034 T17955 T17964 themeOf S9E,phosphorylated
R12035 T17957 T17965 themeOf TNFα mRNA,upregulation
R12036 T17967 T17968 themeOf autocrine TNFα,synthesis
R13000 T19538 T19541 themeOf RIP1,Model
R13001 T19539 T19542 themeOf Akt,Model
R13002 T19540 T19543 themeOf JNK,Model
R13003 T19546 T19548 themeOf Akt kinase,engaged
R13004 T19547 T19549 themeOf RIP1 kinase,leads
R13005 T19550 T19551 themeOf Akt,phosphorylation
R13006 T19551 T19552 themeOf phosphorylation,requires
R13007 T19553 T19554 themeOf Akt,localization
R13008 T19555 T19557 themeOf Akt,Expression
R13009 T19556 T19558 themeOf Myr-Akt,Expression
R13010 T19559 T19561 themeOf Myr,expression
R13011 T19560 T19562 themeOf Akt,expression
R13012 T19561 T19563 themeOf expression,sufficient
R13013 T19562 T19564 themeOf expression,sufficient
R13014 T19566 T19569 themeOf Thr308,phosphorylation
R13015 T19567 T19570 themeOf Akt,phosphorylation
R13016 T19568 T19571 themeOf caspase,inhibition
R13017 T19569 T19572 themeOf phosphorylation,required
R13018 T19570 T19573 themeOf phosphorylation,required
R13019 T19574 T19578 themeOf Akt,inhibitors
R13020 T19575 T19579 themeOf Akt,knockdown
R13021 T19576 T19580 themeOf Akt mutants,expression
R13022 T19577 T19581 themeOf Akt,activation
R13023 T19578 T19582 themeOf inhibitors,Using
R13024 T19579 T19583 themeOf knockdown,Using
R13025 T19580 T19584 themeOf expression,Using
R13026 T19580 T19585 themeOf expression,inhibitors
R13027 T19586 T19589 themeOf Thr308,phosphorylation
R13028 T19587 T19590 themeOf Akt,phosphorylation
R13029 T19591 T19595 themeOf Akt,activation
R13030 T19593 T19596 themeOf JNK,activation
R13031 T19594 T19597 themeOf autocrine TNFα,synthesis
R13032 T19596 T19598 themeOf activation,connecting
R13033 T19597 T19599 themeOf synthesis,activation
R13034 T19600 T19602 themeOf Akt,phosphorylation
R13035 T19601 T19603 themeOf JNK,inhibition
R13036 T19602 T19604 themeOf phosphorylation,examined
R13037 T19605 T19606 themeOf Akt,phosphorylation
R13038 T19606 T19607 themeOf phosphorylation,inhibited
R13039 T19610 T19611 themeOf Akt,inhibit
R13040 T19610 T19612 themeOf Akt,phosphorylation
R13041 T19612 T19613 themeOf phosphorylation,inhibit
R13042 T19615 T19621 themeOf JNK,inhibitor
R13043 T19622 T19625 themeOf JNK1,inhibition
R13044 T19623 T19626 themeOf Akt,phosphorylation
R13045 T19624 T19627 themeOf c-Jun,phosphorylation
R13046 T19627 T19628 themeOf phosphorylation,inhibiting
R13047 T19629 T19631 themeOf TNFα,production
R13048 T19631 T19632 themeOf production,reduction
R13049 T19633 T19638 causeOf c-Jun,role
R13050 T19634 T19636 themeOf autocrine TNFα,synthesis
R13051 T19635 T19637 themeOf c-Jun siRNA,knockdown
R13052 T19636 T19638 themeOf synthesis,role
R13053 T19639 T19642 themeOf autocrine TNFα,production
R13054 T19640 T19643 causeOf c-Jun,dependent
R13055 T19641 T19644 themeOf Akt,activation
R13056 T19642 T19643 themeOf production,dependent
R13057 T19645 T19650 themeOf c-Jun,increase
R13058 T19645 T19651 themeOf c-Jun,increase
R13059 T19647 T19651 causeOf TNFα,increase
R13060 T19654 T19655 themeOf c-Jun,phosphorylation
R1450 T2155 T2156 themeOf caspase,induced
R1451 T2157 T2159 themeOf RIP1,activated
R1452 T2158 T2160 themeOf RIP3,activated
R1454 T2161 T2163 themeOf JNK kinase,activation
R1457 T2165 T2167 themeOf JNK,Activation
R1459 T2166 T2168 themeOf autocrine TNFα,synthesis
R1460 T2170 T2172 themeOf JNK,production
R1465 T2171 T2173 themeOf TNFα,production
R1468 T2172 T2174 themeOf production,activation
R1470 T2173 T2175 themeOf production,activation
R1472 T2177 T2179 causeOf insulin,activation
R1473 T2178 T2179 themeOf Akt,activation
R1474 T2180 T2184 causeOf insulin,dependent
R1476 T2181 T2184 themeOf Akt,dependent
R1478 T2182 T2185 themeOf Akt,activation
R1479 T2189 T2191 themeOf Akt,activated
R1482 T2194 T2195 themeOf TNFα,production
R1483 T2195 T2196 themeOf production,activation
R1484 T2196 T2197 themeOf activation,contributes
R1486 T2200 T2201 themeOf JNK,activation
R1488 T2203 T2204 themeOf TNFα,production
R15481 T23147 T23151 themeOf Akt kinase,engaged
R15482 T23149 T23152 themeOf Akt,phosphorylation
R15483 T23150 T23153 themeOf Thr308,phosphorylation
R15484 T23152 T23154 themeOf phosphorylation,increase
R15485 T23153 T23155 themeOf phosphorylation,increase
R15486 T23156 T23159 themeOf RIP1 kinase,connecting
R15487 T23157 T23160 themeOf JNK,activation
R15488 T23158 T23161 themeOf autocrine TNFα,synthesis
R15489 T23161 T23162 themeOf synthesis,activation
R15490 T23163 T23164 themeOf Akt,phosphorylation
R15491 T23164 T23165 themeOf phosphorylation,requires
R15492 T23166 T23167 themeOf Akt,localization
R15493 T23168 T23170 themeOf Myr,Expression
R15494 T23169 T23171 themeOf Akt,Expression
R15495 T23172 T23176 themeOf Myr,expression
R15496 T23173 T23177 themeOf Akt,expression
R15497 T23174 T23178 themeOf JNK,activation
R15498 T23174 T23179 themeOf JNK,synthesis
R15499 T23175 T23180 themeOf TNFα,synthesis
R15500 T23178 T23181 themeOf activation,sufficient
R15501 T23179 T23182 themeOf synthesis,activation
R15502 T23180 T23183 themeOf synthesis,activation
R15503 T23185 T23187 themeOf Thr308,phosphorylation
R15504 T23186 T23188 themeOf Akt,phosphorylation
R15505 T23187 T23189 themeOf phosphorylation,required
R15506 T23188 T23190 themeOf phosphorylation,required
R15507 T23191 T23194 themeOf Thr308,phosphorylation
R15508 T23192 T23195 themeOf Akt,phosphorylation
R15509 T23196 T23197 themeOf Akt,regulation
R15510 T23198 T23202 causeOf RIP1,dependent
R15511 T23199 T23200 themeOf Akt,phosphorylation
R15512 T23200 T23201 themeOf phosphorylation,increase
R15513 T23201 T23202 themeOf increase,dependent
R15514 T23204 T23205 themeOf Thr308,targets
R15515 T23207 T23209 themeOf PP2A,inhibitor
R15516 T23208 T23210 themeOf Thr308,phosphorylation
R15517 T23209 T23212 causeOf inhibitor,effect
R15518 T23209 T23213 causeOf inhibitor,effect
R15519 T23210 T23211 themeOf phosphorylation,activation
R15520 T23210 T23212 themeOf phosphorylation,effect
R15521 T23211 T23213 themeOf activation,effect
R15522 T23217 T23219 themeOf Akt,phosphorylation
R15523 T23218 T23220 themeOf recombinant RIP1 kinase,phosphorylation
R15524 T23223 T23225 themeOf Akt,phosphorylation
R15525 T23224 T23226 themeOf RIP1,phosphorylation
R15526 T23225 T23227 themeOf phosphorylation,regulation
R15527 T23226 T23228 themeOf phosphorylation,regulation
R15528 T23230 T23231 themeOf TNFα,synthesis
R15529 T23235 T23236 themeOf JNK,regulation
R15530 T23237 T23243 themeOf JNK,activation
R15531 T23238 T23243 causeOf TNFα,activation
R15532 T23243 T23244 themeOf activation,control
R15533 T23246 T23248 themeOf Akt,regulation
R15534 T23247 T23249 themeOf RIP1 kinase,regulation
R15535 T23253 T23254 themeOf Akt,activation
R15536 T23259 T23261 themeOf Akt,activation
R15537 T23260 T23262 themeOf mTOR,activation
R15538 T23262 T23263 themeOf activation,inhibition
R15539 T23266 T23270 themeOf autophagy,inhibition
R15540 T23267 T23271 themeOf Akt,inhibition
R15541 T23268 T23270 causeOf mTOR,inhibition
R15542 T23268 T23271 causeOf mTOR,inhibition
R15543 T23275 T23278 themeOf FADD,deficient
R15544 T23277 T23279 themeOf TNFα,synthesis
R15545 T23279 T23280 themeOf synthesis,increase
R15546 T23281 T23284 causeOf RIP1,mediating
R15547 T23282 T23283 themeOf TNFα,production
R15548 T23283 T23284 themeOf production,mediating
R15549 T23286 T23290 themeOf TNFα,synthesis
R15550 T23288 T23289 themeOf Akt,activation
R15551 T23290 T23291 themeOf synthesis,activation
R15552 T23292 T23297 themeOf RIP1,control
R15553 T23293 T23298 themeOf RIP3 kinase,control
R15554 T23294 T23297 causeOf FADD,control
R15555 T23294 T23298 causeOf FADD,control
R15556 T23294 T23299 causeOf FADD,control
R15557 T23295 T23299 themeOf caspase,control
R15558 T23296 T23300 themeOf TNFα,production
R15559 T23301 T23302 themeOf TNFα,production
R15560 T23302 T23303 themeOf production,increased
R15561 T23308 T23309 themeOf RIP1 kinase,inhibitors
R17458 T25532 T25534 themeOf Akt,inhibitor
R17459 T25533 T25535 themeOf JNK,inhibitor
R17460 T25535 T25536 themeOf inhibitor,inhibitor
R18476 T26896 T26903 partOf Mouse ribosomal S6 protein,L-040893-00
R18477 T26897 T26905 themeOf Akt1,control
R18478 T26897 T26903 partOf Akt1,L-040893-00
R18479 T26897 T26904 partOf Akt1,L-065427-00
R18480 T26897 T26906 partOf Akt1,L-043776-00
R19681 T28387 T28388 themeOf GSK fusion protein,Phosphorylation
R20192 T29148 T29156 themeOf Akt,inhibitors
R20193 T29148 T29162 themeOf Akt,inhibitor
R20194 T29149 T29163 themeOf Akt,inhibitor
R20195 T29150 T29157 themeOf JNK,inhibitors
R20196 T29151 T29158 themeOf p38,inhibitors
R20197 T29151 T29164 themeOf p38,inhibitor
R20198 T29152 T29159 themeOf PD169316,inhibitors
R20199 T29153 T29160 themeOf Erk,inhibitors
R20200 T29153 T29165 themeOf Erk,inhibitor
R20201 T29154 T29161 themeOf UO126,inhibitors
R20202 T29162 T29166 themeOf inhibitor,inhibitors
R20203 T29163 T29167 themeOf inhibitor,inhibitors
R20204 T29164 T29168 themeOf inhibitor,inhibitors
R20205 T29165 T29169 themeOf inhibitor,inhibitors
R20206 T29170 T29174 themeOf Akt1,transfected
R20207 T29171 T29175 themeOf Akt2,transfected
R20208 T29172 T29176 themeOf Akt3 siRNAs,transfected
R20209 T29174 T29177 themeOf transfected,transfected
R20210 T29175 T29178 themeOf transfected,transfected
R20211 T29176 T29179 themeOf transfected,transfected
R20212 T29180 T29181 themeOf Akt,expression
R20570 T29678 T29683 causeOf RIP1 kinase,dependent
R20571 T29678 T29684 causeOf RIP1 kinase,dependent
R20572 T29679 T29681 themeOf Akt,phosphorylation
R20573 T29680 T29682 themeOf JNK,phosphorylation
R20574 T29681 T29683 themeOf phosphorylation,dependent
R20575 T29682 T29684 themeOf phosphorylation,dependent
R20752 T29973 T29975 themeOf Thr308,phosphorylation
R20753 T29974 T29976 themeOf Akt,phosphorylation
R20754 T29975 T29977 themeOf phosphorylation,contributes
R20755 T29976 T29978 themeOf phosphorylation,contributes
R212 T456 T461 causeOf Akt,Regulates
R21200 T30581 T30584 themeOf Akt,inhibitors
R21201 T30582 T30585 themeOf Akt,inhibitors
R21202 T30583 T30586 themeOf mTOR,inhibitors
R21203 T30587 T30589 themeOf mTOR siRNA,knockdown
R213 T457 T459 themeOf TNFα,Synthesis
R21362 T30916 T30923 causeOf Akt,control
R21363 T30916 T30924 causeOf Akt,control
R21364 T30917 T30925 causeOf mTORC1,control
R21365 T30917 T30926 causeOf mTORC1,control
R21366 T30917 T30927 causeOf mTORC1,control
R21367 T30918 T30920 themeOf TNFα,synthesis
R21368 T30919 T30921 themeOf JNK,activation
R21369 T30920 T30922 themeOf synthesis,activation
R21370 T30920 T30925 themeOf synthesis,control
R21371 T30921 T30923 themeOf activation,control
R21372 T30921 T30926 themeOf activation,control
R21373 T30922 T30924 themeOf activation,control
R21374 T30922 T30927 themeOf activation,control
R21375 T30938 T30941 themeOf Akt,knockdown
R214 T458 T460 themeOf RIP1 Kinase,Activation
R215 T459 T461 themeOf Synthesis,Regulates
R216 T462 T464 themeOf mediator receptor interacting protein-1,controlled
R217 T463 T465 themeOf RIP1,controlled
R218 T467 T468 themeOf TNFα,production
R219 T469 T472 themeOf Akt,activated
R21992 T31719 T31721 themeOf Myr-Akt,expressing
R220 T471 T473 themeOf Thr308,phosphorylation
R221 T473 T474 themeOf phosphorylation,activated
R222 T478 T480 themeOf JNK,activation
R22242 T32195 T32196 themeOf autocrine TNFα,production
R22243 T32201 T32205 themeOf Myr-Akt,expressing
R22244 T32206 T32211 themeOf Akt1,expressing
R22245 T32207 T32212 themeOf Akt2,expressing
R223 T479 T481 themeOf TNFα,activation
R22329 T32443 T32445 themeOf Akt,phosphorylation
R22330 T32445 T32446 themeOf phosphorylation,requires
R22331 T32448 T32450 themeOf JNK,activation
R22332 T32449 T32451 themeOf TNFα,synthesis
R22333 T32452 T32455 themeOf Akt,Activation
R22334 T32453 T32456 themeOf Akt,phosphorylation
R22335 T32454 T32457 themeOf mTOR,phosphorylation
R22336 T32455 T32458 causeOf Activation,leads
R22337 T32455 T32459 causeOf Activation,leads
R22338 T32456 T32458 themeOf phosphorylation,leads
R22339 T32457 T32459 themeOf phosphorylation,leads
R224 T482 T483 themeOf TNFα,production
R225 T483 T484 themeOf production,control
R226 T485 T486 themeOf Akt kinase,regulation
R2751 T4088 T4092 themeOf caspase,loss
R2752 T4090 T4093 themeOf RIP1 kinase,inactivates
R2753 T4091 T4094 themeOf RIP1 deubiquitinase,inactivates
R2754 T4095 T4097 themeOf zVAD.fmk,prevented
R2755 T4104 T4106 themeOf caspase,inhibition
R2756 T4110 T4113 themeOf RIP1 kinase,inhibitor
R2757 T4114 T4116 themeOf zVAD.fmk,blocked
R2758 T4120 T4121 themeOf RIP1 kinase,loss
R2759 T4135 T4137 themeOf bFGF receptor,inhibitor
R4499 T6764 T6769 themeOf JNK,phosphorylation
R4500 T6765 T6770 themeOf TNFα,stimulation
R4501 T6709 T6713 causeOf RIP1 kinase,dependent
R4502 T6768 T6771 themeOf phosphorylation,changes
R4503 T6710 T6711 themeOf Akt,Activation
R4504 T6711 T6712 themeOf Activation,Contributes
R4505 T6711 T6713 themeOf Activation,dependent
R4506 T6769 T6772 themeOf phosphorylation,changes
R4507 T6770 T6773 themeOf stimulation,changes
R4508 T6715 T6716 themeOf growth factor receptor,activation
R4509 T6717 T6721 themeOf Akt,Inhibition
R4510 T6776 T6777 themeOf Akt,phosphorylation
R4511 T6722 T6725 themeOf Akt,Inhibition
R4512 T6777 T6778 themeOf phosphorylation,increase
R4513 T6779 T6781 themeOf Akt,phosphorylation
R4514 T6732 T6735 themeOf p38,inhibition
R4515 T6733 T6736 themeOf ERK,inhibition
R4516 T6780 T6782 themeOf Ser473,phosphorylation
R4517 T6781 T6783 themeOf phosphorylation,changes
R4518 T6738 T6742 themeOf Akt,inhibitors
R4519 T6782 T6784 themeOf phosphorylation,changes
R4520 T6739 T6744 themeOf allosteric kinase,inhibitor
R4521 T6740 T6745 themeOf Akt,translocation
R4522 T6741 T6743 themeOf Fig. S2B,inhibitors
R4523 T6785 T6788 themeOf p46,phosphorylation
R4524 T6745 T6746 themeOf translocation,blocks
R4525 T6786 T6789 themeOf p54,phosphorylation
R4526 T6747 T6753 themeOf Akt,knockdown
R4527 T6748 T6754 themeOf Akt1,knockdown
R4528 T6749 T6755 themeOf Akt2,knockdown
R4529 T6787 T6790 themeOf JNK,phosphorylation
R4530 T6752 T6756 themeOf Fig. 2C,protected
R4531 T6788 T6791 themeOf phosphorylation,increase
R4532 T6789 T6792 themeOf phosphorylation,increase
R4533 T6757 T6759 themeOf Akt3,expression
R4534 T6790 T6793 themeOf phosphorylation,increase
R4535 T6794 T6796 themeOf Akt,activated
R4536 T6761 T6766 themeOf Akt,activation
R4537 T6762 T6767 themeOf JNK,activation
R4538 T6763 T6768 themeOf Akt,phosphorylation
R4539 T6795 T6797 themeOf JNK,activated
R4540 T6799 T6807 causeOf Nec-1,prevented
R4541 T6834 T6840 themeOf JNK,phosphorylation
R4542 T6800 T6805 themeOf Thr308 Akt,phosphorylation
R4543 T6835 T6841 themeOf Jun,phosphorylation
R4544 T6805 T6806 themeOf phosphorylation,increase
R4545 T6842 T6844 themeOf RIP1 kinase,contributions
R4546 T6806 T6807 themeOf increase,prevented
R4547 T6843 T6845 themeOf Akt,regulation
R4548 T6808 T6813 causeOf Nec-1,prevented
R4549 T6845 T6846 themeOf regulation,contributions
R4550 T6847 T6852 themeOf bFGF,addition
R4551 T6809 T6811 themeOf JNK,phosphorylation
R4552 T6849 T6856 themeOf Akt,phosphorylation
R4553 T6849 T6857 themeOf Akt,phosphorylation
R4554 T6849 T6854 partOf Akt,Thr308
R4555 T6849 T6855 partOf Akt,Ser473
R4556 T6850 T6853 themeOf JNK,increase
R4557 T6811 T6812 themeOf phosphorylation,induction
R4558 T6812 T6813 themeOf induction,prevented
R4559 T6814 T6815 themeOf JNK,changes
R4560 T6854 T6856 Site Thr308,phosphorylation
R4561 T6855 T6857 Site Ser473,phosphorylation
R4562 T6856 T6858 themeOf phosphorylation,increase
R4563 T6857 T6859 themeOf phosphorylation,increase
R4564 T6817 T6821 themeOf Nec-1,phosphorylation
R4565 T6862 T6865 themeOf Akt,phosphorylation
R4566 T6818 T6822 themeOf Akt,phosphorylation
R4567 T6863 T6866 themeOf JNK,phosphorylation
R4568 T6864 T6867 themeOf Jun,phosphorylation
R4569 T6865 T6868 themeOf phosphorylation,increase
R4570 T6819 T6823 themeOf JNK,phosphorylation
R4571 T6866 T6869 themeOf phosphorylation,increase
R4572 T6867 T6870 themeOf phosphorylation,increase
R4573 T6824 T6827 themeOf Akt Thr308,phosphorylation
R4574 T6871 T6886 causeOf Nec-1,increase
R4575 T6871 T6893 causeOf Nec-1,increase
R4576 T6871 T6894 causeOf Nec-1,increase
R4577 T6871 T6895 causeOf Nec-1,increase
R4578 T6872 T6886 themeOf Akt,increase
R4579 T6872 T6887 themeOf Akt,phosphorylation
R4580 T6824 T6829 causeOf Akt Thr308,dependent
R4581 T6873 T6888 themeOf JNK,phosphorylation
R4582 T6824 T6830 causeOf Akt Thr308,dependent
R4583 T6825 T6828 themeOf JNK,phosphorylation
R4584 T6874 T6889 themeOf c-Jun,phosphorylation
R4585 T6826 T6831 causeOf RIP1,dependent
R4586 T6878 T6896 causeOf Nec-1,blocked
R4587 T6826 T6832 causeOf RIP1,dependent
R4588 T6879 T6897 causeOf analog Nec-1i,blocked
R4589 T6827 T6829 themeOf phosphorylation,dependent
R4590 T6882 T6890 themeOf bFGF/zVAD,increase
R4591 T6827 T6831 themeOf phosphorylation,dependent
R4592 T6883 T6891 themeOf Akt,activation
R4593 T6828 T6830 themeOf phosphorylation,dependent
R4594 T6884 T6892 themeOf JNK,activation
R4595 T6828 T6832 themeOf phosphorylation,dependent
R4596 T6833 T6839 themeOf Akt Thr308,phosphorylation
R4597 T6887 T6893 themeOf phosphorylation,increase
R4598 T6888 T6894 themeOf phosphorylation,increase
R4599 T6889 T6895 themeOf phosphorylation,increase
R4600 T6890 T6896 themeOf increase,blocked
R4601 T6890 T6897 themeOf increase,blocked
R4602 T6918 T6919 themeOf phosphorylation,increase
R4603 T6920 T6923 themeOf Akt,increases
R4604 T6898 T6908 causeOf IGF,increase
R4605 T6920 T6924 themeOf Akt,phosphorylation
R4606 T6900 T6905 themeOf Thr308,phosphorylation
R4607 T6901 T6909 causeOf Akt,increase
R4608 T6921 T6925 themeOf JNK,phosphorylation
R4609 T6903 T6906 themeOf Fig,phosphorylation
R4610 T6904 T6907 themeOf S3C,phosphorylation
R4611 T6905 T6908 themeOf phosphorylation,increase
R4612 T6905 T6909 themeOf phosphorylation,increase
R4613 T6906 T6910 themeOf phosphorylation,increase
R4614 T6924 T6926 themeOf phosphorylation,increases
R4615 T6907 T6911 themeOf phosphorylation,increase
R4616 T6925 T6927 themeOf phosphorylation,increases
R4617 T6912 T6917 themeOf Akt Thr308,phosphorylation
R4618 T6913 T6919 causeOf RIP1,increase
R4620 T6914 T6918 themeOf Akt,phosphorylation
R5196 T7943 T7946 themeOf TNFα Induces Delayed Akt,Phosphorylation
R5197 T7944 T7947 themeOf Thr308,Phosphorylation
R5198 T7949 T7956 themeOf FGFR,inhibitors
R5199 T7951 T7957 themeOf Akt,phosphorylation
R5200 T7952 T7958 themeOf JNK,phosphorylation
R5201 T7960 T7963 themeOf Akt p308,activation
R5202 T7964 T7966 themeOf JNK,activation
R5203 T7965 T7966 causeOf TNFα,activation
R5204 T7968 T7970 themeOf JNK,phosphorylation
R5205 T7969 T7971 themeOf c-Jun,phosphorylation
R5206 T7970 T7972 themeOf phosphorylation,increase
R5207 T7971 T7973 themeOf phosphorylation,increase
R5208 T7975 T7977 themeOf pJNK,levels
R5209 T7976 T7978 themeOf Jun,levels
R5210 T7977 T7979 themeOf levels,reduced
R5211 T7978 T7980 themeOf levels,reduced
R5212 T7982 T7985 causeOf Ask1,activate
R5213 T7983 T7985 themeOf JNK,activate
R5751 T8736 T8738 themeOf Akt,phosphorylation
R5752 T8737 T8739 themeOf Thr308,phosphorylation
R5753 T8738 T8740 themeOf phosphorylation,increase
R5754 T8739 T8741 themeOf phosphorylation,increase
R5755 T8742 T8744 causeOf PDGF/zVAD.fmk,triggered
R5756 T8742 T8747 causeOf PDGF/zVAD.fmk,triggered
R5757 T8743 T8744 themeOf JNK,triggered
R5758 T8743 T8745 themeOf JNK,phosphorylation
R5759 T8745 T8746 themeOf phosphorylation,activation
R5760 T8745 T8747 themeOf phosphorylation,triggered
R5761 T8748 T8752 themeOf Akt,inhibitor
R5762 T8753 T8754 themeOf Thr308,phosphorylation
R5763 T8758 T8759 themeOf Akt,activation
R5764 T8760 T8762 themeOf Akt,activation
R5765 T8761 T8763 themeOf Akt,activation
R6816 T10532 T10533 themeOf Akt kinase,increase
R6817 T10542 T10545 themeOf FoxO1,increase
R6818 T10548 T10553 themeOf Akt,phosphorylation
R6819 T10549 T10551 themeOf Fig. 5B,phosphorylation
R6820 T10550 T10552 themeOf S5A,phosphorylation
R6821 T10553 T10554 themeOf phosphorylation,increase
R6822 T10555 T10560 themeOf Akt,increases
R6823 T10556 T10561 causeOf Nec-1,abrogated
R6824 T10556 T10562 causeOf Nec-1,abrogated
R6825 T10557 T10561 themeOf Fig. 5A,abrogated
R6826 T10560 T10562 themeOf increases,abrogated
R6827 T10566 T10568 themeOf mTORC1,inhibition
R6828 T10567 T10569 themeOf mTOR,inhibitor
R6829 T10570 T10573 themeOf mTOR kinase,inhibitor
R6830 T10571 T10574 themeOf PI3K,inhibitor
R6831 T10572 T10575 themeOf mTOR,inhibitor
R6832 T10576 T10580 themeOf mTOR using siRNA,Knockdown
R6833 T10581 T10584 causeOf mTORC1,regulates
R6834 T10582 T10583 themeOf p70S6 kinase,activation
R6835 T10583 T10584 themeOf activation,regulates
R6836 T10585 T10586 themeOf S6,phosphorylation
R6837 T10586 T10587 themeOf phosphorylation,block
R6838 T10588 T10591 themeOf S6,knockdown
R6839 T10593 T10599 causeOf RIP1 kinase,control
R6840 T10594 T10600 causeOf Akt,control
R6841 T10595 T10601 causeOf mTORC1,control
R6842 T10596 T10602 causeOf JNK,control
R6843 T10597 T10598 themeOf TNFα,upregulation
R6844 T10598 T10599 themeOf upregulation,control
R6845 T10598 T10600 themeOf upregulation,control
R6846 T10598 T10601 themeOf upregulation,control
R6847 T10598 T10602 themeOf upregulation,control
R6848 T10603 T10604 themeOf TNFα,synthesis
R6849 T10605 T10606 themeOf TNFα,synthesis
R6850 T10607 T10614 causeOf RIP1,increase
R6851 T10607 T10615 causeOf RIP1,increase
R6852 T10608 T10614 themeOf TNFα protein,increase
R6853 T10610 T10615 themeOf S6A,increase
R6854 T10611 T10616 themeOf TNFα mRNA,increased
R6855 T10612 T10617 themeOf RIP1,increased
R6856 T10613 T10616 causeOf Fig,increased
R6857 T10613 T10617 causeOf Fig,increased
R6858 T10619 T10624 causeOf bFGF,triggered
R6859 T10620 T10623 themeOf TNFα mRNA,induction
R6860 T10623 T10624 themeOf induction,triggered
R6861 T10625 T10633 causeOf PDGF,caused
R6862 T10626 T10630 themeOf TNFα mRNA,upregulation
R6863 T10628 T10631 causeOf Fig. 6A,increased
R6864 T10629 T10632 themeOf autocrine TNFα,synthesis
R6865 T10630 T10631 themeOf upregulation,increased
R6866 T10630 T10633 themeOf upregulation,caused
R6867 T10632 T10634 themeOf synthesis,increase
R6868 T10635 T10645 causeOf Akt,contribute
R6869 T10636 T10646 causeOf mTORC1,contribute
R6870 T10637 T10640 themeOf TNFα mRNA,upregulation
R6871 T10638 T10641 themeOf Akt,siRNA
R6872 T10638 T10642 themeOf Akt,knockdown
R6873 T10639 T10644 themeOf mTOR reduced TNFα mRNA,levels
R6874 T10640 T10645 themeOf upregulation,contribute
R6875 T10640 T10646 themeOf upregulation,contribute
R6876 T10641 T10643 themeOf siRNA,knockdown
R6877 T10642 T10647 themeOf knockdown,inhibition
R6878 T10642 T10649 themeOf knockdown,siRNA
R6879 T10643 T10648 themeOf knockdown,inhibition
R6880 T10643 T10650 themeOf knockdown,siRNA
R6881 T10651 T10656 themeOf RIP1,inhibitors
R6882 T10652 T10657 themeOf Akt,inhibitors
R6883 T10653 T10658 themeOf TNFα mRNA,effect
R6884 T10653 T10659 themeOf TNFα mRNA,effect
R6885 T10655 T10660 themeOf TNFα,synthesis
R6886 T10656 T10658 causeOf inhibitors,effect
R6887 T10657 T10659 causeOf inhibitors,effect
R6888 T10660 T10661 themeOf synthesis,increase
R8295 T12495 T12500 causeOf Akt,Control
R8296 T12495 T12501 causeOf Akt,Control
R8297 T12496 T12502 causeOf mTORC1,Control
R8298 T12496 T12503 causeOf mTORC1,Control
R8299 T12497 T12498 themeOf JNK,Activation
R8300 T12498 T12500 themeOf Activation,Control
R8301 T12498 T12501 themeOf Activation,Control
R8302 T12498 T12502 themeOf Activation,Control
R8303 T12498 T12503 themeOf Activation,Control
R8304 T12499 T12501 Site Necroptosis,Control
R8305 T12499 T12503 Site Necroptosis,Control
R8306 T12504 T12507 causeOf JNK,regulator
R8307 T12505 T12506 themeOf TNFα,synthesis
R8308 T12506 T12507 themeOf synthesis,regulator
R8309 T12510 T12512 themeOf TNFα mRNA,increase
R8310 T12511 T12513 themeOf JNK,activation
R8311 T12512 T12514 themeOf increase,block
R8312 T12513 T12515 themeOf activation,role
R8313 T12521 T12525 themeOf c-Jun,phosphorylation
R8314 T12524 T12526 themeOf JNK,activation
R8315 T12525 T12527 themeOf phosphorylation,increase
R8316 T12528 T12534 themeOf Akt,inhibition
R8317 T12529 T12535 themeOf bFGF/zVAD.fmk,increase
R8318 T12530 T12536 themeOf JNK,phosphorylation
R8319 T12531 T12537 themeOf c-Jun,phosphorylation
R8320 T12533 T12538 causeOf S6F,induced
R8321 T12533 T12539 causeOf S6F,induced
R8322 T12536 T12538 themeOf phosphorylation,induced
R8323 T12537 T12539 themeOf phosphorylation,induced
R8324 T12540 T12544 themeOf mTOR,Knockdown
R8325 T12540 T12545 themeOf mTOR,inhibitor
R8326 T12541 T12546 themeOf p70S6K,inhibitor
R8327 T12542 T12547 themeOf JNK,phosphorylation
R8328 T12543 T12548 themeOf c-Jun,phosphorylation
R8329 T12544 T12551 causeOf Knockdown,attenuated
R8330 T12544 T12552 causeOf Knockdown,attenuated
R8331 T12547 T12549 themeOf phosphorylation,increase
R8332 T12548 T12550 themeOf phosphorylation,increase
R8333 T12549 T12551 themeOf increase,attenuated
R8334 T12550 T12552 themeOf increase,attenuated
R8335 T12554 T12559 causeOf mTORC1,required
R8336 T12557 T12558 themeOf JNK,increase
R8337 T12558 T12559 themeOf increase,required
R8806 T13267 T13272 themeOf Akt,regulation
R8807 T13268 T13273 partOf pleckstrin homology,domain
R8808 T13269 T13273 partOf PH,domain
R8809 T13270 T13274 themeOf Akt,binding
R8810 T13270 T13273 partOf Akt,domain
R8811 T13271 T13274 themeOf PI3K,binding
R8812 T13273 T13274 Site domain,binding
R8813 T13275 T13279 themeOf Akt,phosphorylated
R8814 T13276 T13280 themeOf protein kinase-1,phosphorylated
R8815 T13277 T13281 themeOf PDK1,phosphorylated
R8816 T13278 T13282 themeOf mTORC2,phosphorylated
R8817 T13283 T13286 themeOf Thr308 Akt,phosphorylation
R8818 T13284 T13288 themeOf PI3K,dependent
R8819 T13285 T13289 themeOf PDK1,dependent
R8820 T13286 T13287 themeOf phosphorylation,increased
R8821 T13290 T13295 themeOf PI3K,Inhibition
R8822 T13291 T13296 themeOf PDK1,Inhibition
R8823 T13292 T13297 themeOf Akt Thr308,phosphorylation
R8824 T13293 T13298 themeOf Fig,phosphorylation
R8825 T13294 T13299 themeOf S7A–D,phosphorylation
R8826 T13297 T13300 themeOf phosphorylation,inhibition
R8827 T13298 T13301 themeOf phosphorylation,inhibition
R8828 T13299 T13302 themeOf phosphorylation,inhibition
R8829 T13303 T13307 themeOf PDK1,knockdown
R8830 T13304 T13308 themeOf Akt Thr308,phosphorylation
R8831 T13305 T13309 themeOf PI3K,required
R8832 T13306 T13310 themeOf PDK1,required
R8833 T13307 T13309 causeOf knockdown,required
R8834 T13307 T13310 causeOf knockdown,required
R8835 T13307 T13311 causeOf knockdown,inhibited
R8836 T13308 T13311 themeOf phosphorylation,inhibited