| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1146 |
0-9 |
Positive_regulation |
denotes |
Increased |
| T1147 |
0-9 |
Positive_regulation |
denotes |
Increased |
| T1144 |
25-35 |
Gene_expression |
denotes |
production |
| T1145 |
25-35 |
Gene_expression |
denotes |
production |
| T1142 |
42-67 |
Protein |
denotes |
phosphoinositide 3-kinase |
| T1143 |
68-71 |
Protein |
denotes |
Akt |
| T1148 |
273-292 |
Protein |
denotes |
Interleukin (IL)-17 |
| T1150 |
461-471 |
Gene_expression |
denotes |
expression |
| T1149 |
504-509 |
Protein |
denotes |
IL-17 |
| T1153 |
708-716 |
Regulation |
denotes |
regulate |
| T1151 |
717-722 |
Protein |
denotes |
IL-17 |
| T1152 |
723-733 |
Gene_expression |
denotes |
production |
| T1160 |
792-796 |
Regulation |
denotes |
role |
| T1154 |
804-829 |
Protein |
denotes |
phosphoinositide 3-kinase |
| T1155 |
831-835 |
Protein |
denotes |
PI3K |
| T1156 |
837-840 |
Protein |
denotes |
Akt |
| T1159 |
856-866 |
Regulation |
denotes |
regulation |
| T1157 |
870-875 |
Protein |
denotes |
IL-17 |
| T1158 |
876-886 |
Gene_expression |
denotes |
production |
| T1161 |
1029-1037 |
Protein |
denotes |
anti-CD3 |
| T1162 |
1039-1048 |
Protein |
denotes |
anti-CD28 |
| T1163 |
1050-1068 |
Protein |
denotes |
phytohemagglutinin |
| T1164 |
1070-1073 |
Protein |
denotes |
PHA |
| T1165 |
1126-1131 |
Protein |
denotes |
IL-17 |
| T1170 |
1258-1268 |
Gene_expression |
denotes |
production |
| T1166 |
1272-1277 |
Protein |
denotes |
IL-17 |
| T1171 |
1296-1305 |
Positive_regulation |
denotes |
increased |
| T1167 |
1328-1345 |
Protein |
denotes |
anti-CD3 antibody |
| T1168 |
1362-1371 |
Protein |
denotes |
anti-CD28 |
| T1169 |
1376-1379 |
Protein |
denotes |
PHA |
| T1172 |
1431-1472 |
Protein |
denotes |
IL-15, monocyte chemoattractant protein-1 |
| T1173 |
1477-1481 |
Protein |
denotes |
IL-6 |
| T1180 |
1482-1493 |
Positive_regulation |
denotes |
upregulated |
| T1179 |
1482-1493 |
Positive_regulation |
denotes |
upregulated |
| T1174 |
1494-1499 |
Protein |
denotes |
IL-17 |
| T1178 |
1500-1510 |
Gene_expression |
denotes |
production |
| T1175 |
1531-1554 |
Protein |
denotes |
tumor necrosis factor-α |
| T1176 |
1556-1561 |
Protein |
denotes |
IL-1β |
| T1177 |
1563-1568 |
Protein |
denotes |
IL-18 |
| T1181 |
1610-1615 |
Protein |
denotes |
IL-17 |
| T1183 |
1625-1633 |
Gene_expression |
denotes |
detected |
| T1184 |
1689-1699 |
Gene_expression |
denotes |
expression |
| T1182 |
1737-1744 |
Protein |
denotes |
RA PBMC |
| T1185 |
1746-1763 |
Protein |
denotes |
Anti-CD3 antibody |
| T1190 |
1764-1773 |
Positive_regulation |
denotes |
activated |
| T1186 |
1778-1782 |
Protein |
denotes |
PI3K |
| T1187 |
1783-1786 |
Protein |
denotes |
Akt |
| T1192 |
1848-1860 |
Positive_regulation |
denotes |
augmentation |
| T1191 |
1848-1860 |
Positive_regulation |
denotes |
augmentation |
| T1188 |
1864-1881 |
Protein |
denotes |
nuclear factor κB |
| T1189 |
1883-1888 |
Protein |
denotes |
NF-κB |
| T1197 |
1918-1928 |
Gene_expression |
denotes |
production |
| T1199 |
1932-1941 |
Positive_regulation |
denotes |
activated |
| T1198 |
1932-1941 |
Positive_regulation |
denotes |
activated |
| T1193 |
1942-1949 |
Protein |
denotes |
RA PBMC |
| T1200 |
1974-1981 |
Negative_regulation |
denotes |
blocked |
| T1194 |
2005-2010 |
Protein |
denotes |
NF-κB |
| T1195 |
2057-2061 |
Protein |
denotes |
PI3K |
| T1196 |
2062-2065 |
Protein |
denotes |
Akt |
| T1202 |
2066-2075 |
Negative_regulation |
denotes |
inhibitor |
| T1201 |
2066-2075 |
Negative_regulation |
denotes |
inhibitor |
| T1207 |
2124-2134 |
Negative_regulation |
denotes |
inhibition |
| T1206 |
2124-2134 |
Negative_regulation |
denotes |
inhibition |
| T1203 |
2138-2157 |
Protein |
denotes |
activator protein-1 |
| T1204 |
2162-2203 |
Protein |
denotes |
extracellular signal-regulated kinase 1/2 |
| T1210 |
2212-2218 |
Regulation |
denotes |
affect |
| T1209 |
2212-2218 |
Regulation |
denotes |
affect |
| T1205 |
2219-2224 |
Protein |
denotes |
IL-17 |
| T1208 |
2225-2235 |
Gene_expression |
denotes |
production |
| T1211 |
2306-2310 |
Protein |
denotes |
PI3K |
| T1212 |
2311-2314 |
Protein |
denotes |
Akt |
| T1213 |
2319-2324 |
Protein |
denotes |
NF-κB |
| T1215 |
2345-2359 |
Gene_expression |
denotes |
overproduction |
| T1214 |
2384-2398 |
Protein |
denotes |
cytokine IL-17 |
| T3604 |
2713-2723 |
Negative_regulation |
denotes |
inhibitors |
| T3603 |
2713-2723 |
Negative_regulation |
denotes |
inhibitors |
| T3601 |
2727-2756 |
Protein |
denotes |
tumor necrosis factor (TNF)-α |
| T3602 |
2762-2780 |
Protein |
denotes |
interleukin (IL)-1 |
| T3605 |
3199-3203 |
Protein |
denotes |
IL-2 |
| T3606 |
3208-3220 |
Protein |
denotes |
interferon-γ |
| T3607 |
3296-3300 |
Protein |
denotes |
IL-1 |
| T3608 |
3302-3306 |
Protein |
denotes |
IL-6 |
| T3609 |
3308-3313 |
Protein |
denotes |
IL-15 |
| T3610 |
3315-3320 |
Protein |
denotes |
IL-18 |
| T3611 |
3325-3330 |
Protein |
denotes |
TNF-α |
| T3618 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3617 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3616 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3615 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3614 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3613 |
3336-3344 |
Gene_expression |
denotes |
abundant |
| T3612 |
3348-3367 |
Protein |
denotes |
rheumatoid synovium |
| T3619 |
3555-3571 |
Protein |
denotes |
type II collagen |
| T3620 |
3700-3705 |
Protein |
denotes |
IL-17 |
| T3625 |
3743-3751 |
Localization |
denotes |
secreted |
| T3624 |
3743-3751 |
Localization |
denotes |
secreted |
| T3623 |
3743-3751 |
Localization |
denotes |
secreted |
| T3627 |
3791-3797 |
Positive_regulation |
denotes |
induce |
| T3626 |
3791-3797 |
Positive_regulation |
denotes |
induce |
| T3621 |
3798-3802 |
Protein |
denotes |
IL-6 |
| T3622 |
3807-3811 |
Protein |
denotes |
IL-8 |
| T3628 |
3904-3909 |
Protein |
denotes |
TNF-α |
| T3629 |
3914-3918 |
Protein |
denotes |
IL-1 |
| T3630 |
3920-3925 |
Protein |
denotes |
IL-17 |
| T3631 |
4035-4040 |
Protein |
denotes |
IL-17 |
| T3632 |
4137-4154 |
Protein |
denotes |
nuclear factor κB |
| T3635 |
4225-4235 |
Positive_regulation |
denotes |
stimulates |
| T3634 |
4240-4250 |
Gene_expression |
denotes |
production |
| T3633 |
4254-4258 |
Protein |
denotes |
IL-6 |
| T3638 |
4443-4449 |
Gene_expression |
denotes |
Levels |
| T3636 |
4453-4458 |
Protein |
denotes |
IL-17 |
| T3639 |
4497-4503 |
Positive_regulation |
denotes |
higher |
| T3637 |
4590-4594 |
Protein |
denotes |
CD4+ |
| T3640 |
4628-4633 |
Protein |
denotes |
IL-15 |
| T3641 |
4635-4643 |
Localization |
denotes |
secreted |
| T3642 |
4953-4957 |
Protein |
denotes |
CD4+ |
| T3643 |
4962-4966 |
Protein |
denotes |
CD8+ |
| T3644 |
5010-5015 |
Protein |
denotes |
IL-17 |
| T3645 |
5241-5246 |
Protein |
denotes |
IL-17 |
| T3646 |
5247-5257 |
Gene_expression |
denotes |
production |
| T3647 |
5386-5411 |
Protein |
denotes |
phosphoinositide 3-kinase |
| T3648 |
5413-5417 |
Protein |
denotes |
PI3K |
| T3649 |
5419-5422 |
Protein |
denotes |
Akt |
| T3650 |
5427-5432 |
Protein |
denotes |
NF-κB |
| T3652 |
5458-5472 |
Gene_expression |
denotes |
overproduction |
| T3651 |
5497-5511 |
Protein |
denotes |
cytokine IL-17 |
| T5560 |
6466-6483 |
Protein |
denotes |
Recombinant IL-17 |
| T5561 |
6485-6490 |
Protein |
denotes |
IL-18 |
| T5562 |
6492-6533 |
Protein |
denotes |
IL-15, monocyte chemoattractant protein-1 |
| T5563 |
6585-6591 |
Protein |
denotes |
MIP-1β |
| T5564 |
6593-6597 |
Protein |
denotes |
IL-6 |
| T5565 |
6602-6606 |
Protein |
denotes |
IL-8 |
| T5566 |
6755-6772 |
Protein |
denotes |
Recombinant TNF-α |
| T5567 |
6777-6781 |
Protein |
denotes |
IL-1 |
| T5568 |
6802-6813 |
Protein |
denotes |
Endogen Inc |
| T5569 |
6901-6919 |
Protein |
denotes |
Phytohemagglutinin |
| T5570 |
6921-6924 |
Protein |
denotes |
PHA |
| T5572 |
7010-7018 |
Gene_expression |
denotes |
obtained |
| T5571 |
7010-7018 |
Gene_expression |
denotes |
obtained |
| T5573 |
7068-7096 |
Protein |
denotes |
Anti-CD3 monoclonal antibody |
| T5574 |
7101-7130 |
Protein |
denotes |
anti-CD28 monoclonal antibody |
| T6941 |
8322-8325 |
Protein |
denotes |
CD4 |
| T6942 |
8357-8360 |
Protein |
denotes |
CD4 |
| T6943 |
8506-8509 |
Protein |
denotes |
CD4 |
| T6944 |
8823-8837 |
Protein |
denotes |
MACS MS column |
| T6945 |
9052-9055 |
Protein |
denotes |
CD4 |
| T6946 |
9056-9069 |
Protein |
denotes |
phycoerythrin |
| T6947 |
9400-9405 |
Protein |
denotes |
CD4 T |
| T7796 |
9463-9468 |
Protein |
denotes |
IL-17 |
| T7797 |
9765-9778 |
Protein |
denotes |
serum albumin |
| T7798 |
9780-9783 |
Protein |
denotes |
BSA |
| T7799 |
10254-10264 |
Protein |
denotes |
peroxidase |
| T7800 |
10583-10588 |
Protein |
denotes |
IL-17 |
| T7801 |
10613-10636 |
Protein |
denotes |
Recombinant human IL-17 |
| T7802 |
10878-10883 |
Protein |
denotes |
IL-17 |
| T8686 |
10920-10930 |
Protein |
denotes |
IL-17 mRNA |
| T8687 |
11050-11058 |
Protein |
denotes |
anti-CD3 |
| T8688 |
11497-11515 |
Protein |
denotes |
Taq DNA polymerase |
| T8689 |
11868-11908 |
Protein |
denotes |
glyceraldehyde-3-phosphate dehydrogenase |
| T8690 |
11910-11915 |
Protein |
denotes |
GAPDH |
| T8691 |
11957-11962 |
Protein |
denotes |
GAPDH |
| T8692 |
12176-12181 |
Protein |
denotes |
GAPDH |
| T8693 |
12186-12191 |
Protein |
denotes |
IL-17 |
| T8694 |
12287-12292 |
Protein |
denotes |
GAPDH |
| T8695 |
12297-12302 |
Protein |
denotes |
IL-17 |
| T8696 |
12480-12485 |
Protein |
denotes |
GAPDH |
| T8697 |
12486-12493 |
Gene_expression |
denotes |
product |
| T9628 |
12521-12524 |
Protein |
denotes |
Akt |
| T9631 |
12526-12540 |
Phosphorylation |
denotes |
phosphorylated |
| T9629 |
12541-12544 |
Protein |
denotes |
Akt |
| T9630 |
12549-12554 |
Protein |
denotes |
IκB-α |
| T9632 |
13276-13279 |
Protein |
denotes |
Akt |
| T9637 |
13281-13295 |
Phosphorylation |
denotes |
phosphorylated |
| T9636 |
13281-13295 |
Phosphorylation |
denotes |
phosphorylated |
| T9635 |
13281-13295 |
Phosphorylation |
denotes |
phosphorylated |
| T9633 |
13296-13299 |
Protein |
denotes |
Akt |
| T9634 |
13304-13309 |
Protein |
denotes |
IκB-α |
| T9638 |
13467-13472 |
Protein |
denotes |
TBS-T |
| T9639 |
13474-13496 |
Protein |
denotes |
horseradish peroxidase |
| T10427 |
13782-13787 |
Protein |
denotes |
NF-κB |
| T10428 |
13898-13903 |
Protein |
denotes |
NF-κB |
| T10429 |
13965-13968 |
Protein |
denotes |
TAC |
| T10430 |
14081-14105 |
Protein |
denotes |
T4 polynucleotide kinase |
| T10431 |
14107-14113 |
Protein |
denotes |
TaKaRa |
| T10432 |
14809-14823 |
Protein |
denotes |
NF-κB subunits |
| T10433 |
14824-14827 |
Protein |
denotes |
p50 |
| T10434 |
14829-14832 |
Protein |
denotes |
p65 |
| T10435 |
14837-14842 |
Protein |
denotes |
c-Rel |
| T11389 |
15707-15712 |
Protein |
denotes |
IL-17 |
| T11390 |
15935-15940 |
Protein |
denotes |
IL-17 |
| T11392 |
15941-15951 |
Gene_expression |
denotes |
production |
| T11393 |
15952-15962 |
Positive_regulation |
denotes |
stimulated |
| T11391 |
15966-15969 |
Protein |
denotes |
PHA |
| T11985 |
16120-16129 |
Positive_regulation |
denotes |
Increased |
| T11984 |
16120-16129 |
Positive_regulation |
denotes |
Increased |
| T11983 |
16136-16146 |
Gene_expression |
denotes |
production |
| T11982 |
16136-16146 |
Gene_expression |
denotes |
production |
| T11980 |
16183-16186 |
Protein |
denotes |
CD3 |
| T11981 |
16199-16203 |
Protein |
denotes |
CD28 |
| T11986 |
16221-16226 |
Protein |
denotes |
IL-17 |
| T11988 |
16272-16280 |
Gene_expression |
denotes |
produced |
| T11989 |
16451-16459 |
Positive_regulation |
denotes |
increase |
| T11987 |
16463-16468 |
Protein |
denotes |
IL-17 |
| T11990 |
16569-16577 |
Protein |
denotes |
anti-CD3 |
| T11991 |
16591-16598 |
Protein |
denotes |
Table 1 |
| T11992 |
16600-16608 |
Protein |
denotes |
anti-CD3 |
| T12001 |
16623-16634 |
Positive_regulation |
denotes |
upregulated |
| T11993 |
16635-16640 |
Protein |
denotes |
IL-17 |
| T11998 |
16641-16651 |
Gene_expression |
denotes |
production |
| T11994 |
16691-16700 |
Protein |
denotes |
anti-CD28 |
| T11995 |
16705-16713 |
Protein |
denotes |
anti-CD3 |
| T12000 |
16714-16722 |
Gene_expression |
denotes |
produced |
| T11999 |
16714-16722 |
Gene_expression |
denotes |
produced |
| T11996 |
16723-16733 |
Protein |
denotes |
more IL-17 |
| T11997 |
16773-16776 |
Protein |
denotes |
CD3 |
| T12002 |
16841-16844 |
Protein |
denotes |
PHA |
| T12008 |
16846-16855 |
Positive_regulation |
denotes |
increased |
| T12003 |
16856-16861 |
Protein |
denotes |
IL-17 |
| T12006 |
16862-16872 |
Gene_expression |
denotes |
production |
| T12007 |
16893-16897 |
Binding |
denotes |
than |
| T12004 |
16903-16911 |
Protein |
denotes |
anti-CD3 |
| T12005 |
16916-16925 |
Protein |
denotes |
anti-CD28 |
| T12876 |
16970-16980 |
Regulation |
denotes |
Regulation |
| T12874 |
16984-16989 |
Protein |
denotes |
IL-17 |
| T12875 |
16990-17000 |
Gene_expression |
denotes |
production |
| T12877 |
17061-17068 |
Protein |
denotes |
RA PBMC |
| T12878 |
17473-17478 |
Protein |
denotes |
IL-15 |
| T12879 |
17504-17509 |
Protein |
denotes |
IL-1β |
| T12880 |
17522-17527 |
Protein |
denotes |
TNF-α |
| T12881 |
17540-17545 |
Protein |
denotes |
IL-18 |
| T12882 |
17560-17565 |
Protein |
denotes |
TGF-β |
| T12889 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12888 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12887 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12886 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12885 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12884 |
17602-17611 |
Positive_regulation |
denotes |
unchanged |
| T12883 |
17613-17620 |
Protein |
denotes |
Fig. 2a |
| T12890 |
17661-17665 |
Protein |
denotes |
IL-6 |
| T12895 |
17690-17703 |
Positive_regulation |
denotes |
upregulations |
| T12891 |
17707-17721 |
Protein |
denotes |
IL-17 proteins |
| T12892 |
17835-17839 |
Protein |
denotes |
IL-8 |
| T12893 |
17852-17858 |
Protein |
denotes |
MIP-1α |
| T12894 |
17873-17879 |
Protein |
denotes |
MIP-1β |
| T13879 |
17903-17913 |
Negative_regulation |
denotes |
Inhibition |
| T13877 |
17917-17922 |
Protein |
denotes |
IL-17 |
| T13878 |
17923-17933 |
Gene_expression |
denotes |
production |
| T13880 |
18145-18148 |
Protein |
denotes |
Fig |
| T13881 |
18185-18188 |
Protein |
denotes |
CD3 |
| T13882 |
18250-18255 |
Protein |
denotes |
NF-κB |
| T13884 |
18256-18265 |
Negative_regulation |
denotes |
inhibitor |
| T13883 |
18309-18317 |
Protein |
denotes |
anti-CD3 |
| T13887 |
18422-18431 |
Negative_regulation |
denotes |
inhibitor |
| T13885 |
18435-18439 |
Protein |
denotes |
PI3K |
| T13886 |
18474-18477 |
Protein |
denotes |
CD3 |
| T13888 |
18604-18615 |
Protein |
denotes |
calcineurin |
| T13894 |
18616-18626 |
Negative_regulation |
denotes |
inhibitors |
| T13912 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13911 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13910 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13909 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13896 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13895 |
18656-18669 |
Negative_regulation |
denotes |
downregulated |
| T13889 |
18674-18679 |
Protein |
denotes |
IL-17 |
| T13900 |
18680-18689 |
Localization |
denotes |
secretion |
| T13899 |
18680-18689 |
Localization |
denotes |
secretion |
| T13898 |
18680-18689 |
Localization |
denotes |
secretion |
| T13897 |
18680-18689 |
Localization |
denotes |
secretion |
| T13890 |
18705-18737 |
Protein |
denotes |
mitogen-activated protein kinase |
| T13891 |
18739-18743 |
Protein |
denotes |
MAPK |
| T13892 |
18745-18748 |
Protein |
denotes |
p38 |
| T13907 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13906 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13905 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13904 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13903 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13902 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13901 |
18749-18758 |
Negative_regulation |
denotes |
inhibitor |
| T13908 |
18810-18816 |
Regulation |
denotes |
effect |
| T13893 |
18820-18825 |
Protein |
denotes |
IL-17 |
| T13915 |
18993-19003 |
Negative_regulation |
denotes |
inhibition |
| T13913 |
19007-19012 |
Protein |
denotes |
IL-17 |
| T13914 |
19013-19023 |
Gene_expression |
denotes |
production |
| T13916 |
19117-19124 |
Protein |
denotes |
Fig. 4a |
| T13918 |
19230-19237 |
Regulation |
denotes |
effects |
| T13917 |
19323-19330 |
Protein |
denotes |
Fig. 4b |
| T14572 |
19623-19631 |
Protein |
denotes |
anti-CD3 |
| T14573 |
19659-19663 |
Protein |
denotes |
PI3K |
| T14574 |
19694-19699 |
Protein |
denotes |
NF-κB |
| T15150 |
19726-19736 |
Positive_regulation |
denotes |
Activation |
| T15149 |
19726-19736 |
Positive_regulation |
denotes |
Activation |
| T15147 |
19740-19744 |
Protein |
denotes |
PI3K |
| T15148 |
19745-19748 |
Protein |
denotes |
Akt |
| T15151 |
19859-19863 |
Protein |
denotes |
PI3K |
| T15153 |
19890-19900 |
Positive_regulation |
denotes |
activation |
| T15152 |
19904-19907 |
Protein |
denotes |
Akt |
| T15154 |
19941-19944 |
Protein |
denotes |
Fig |
| T15156 |
20051-20065 |
Phosphorylation |
denotes |
phosphorylated |
| T15155 |
20066-20069 |
Protein |
denotes |
Akt |
| T15160 |
20273-20291 |
Phosphorylation |
denotes |
non-phosphorylated |
| T15159 |
20273-20291 |
Phosphorylation |
denotes |
non-phosphorylated |
| T15157 |
20292-20295 |
Protein |
denotes |
Akt |
| T15158 |
20300-20307 |
Protein |
denotes |
β-actin |
| T15161 |
20358-20361 |
Protein |
denotes |
PHA |
| T15162 |
20363-20377 |
Protein |
denotes |
concanavalin A |
| T15163 |
20382-20387 |
Protein |
denotes |
IL-15 |
| T15166 |
20425-20439 |
Phosphorylation |
denotes |
phosphorylated |
| T15164 |
20440-20443 |
Protein |
denotes |
Akt |
| T15165 |
20463-20466 |
Protein |
denotes |
CD3 |
| T16207 |
20557-20567 |
Positive_regulation |
denotes |
Activation |
| T16206 |
20557-20567 |
Positive_regulation |
denotes |
Activation |
| T16205 |
20557-20567 |
Positive_regulation |
denotes |
Activation |
| T16201 |
20575-20580 |
Protein |
denotes |
NF-κB |
| T16202 |
20585-20604 |
Protein |
denotes |
activator protein-1 |
| T16203 |
20606-20610 |
Protein |
denotes |
AP-1 |
| T16204 |
20627-20641 |
Protein |
denotes |
IL-17 promoter |
| T16208 |
20721-20729 |
Protein |
denotes |
anti-CD3 |
| T16209 |
20735-20744 |
Protein |
denotes |
anti-CD28 |
| T16210 |
20746-20760 |
Protein |
denotes |
concanavalin A |
| T16211 |
20762-20765 |
Protein |
denotes |
PHA |
| T16212 |
20770-20775 |
Protein |
denotes |
IL-15 |
| T16217 |
20797-20805 |
Positive_regulation |
denotes |
inducing |
| T16213 |
20806-20811 |
Protein |
denotes |
IL-17 |
| T16216 |
20812-20822 |
Gene_expression |
denotes |
expression |
| T16214 |
20887-20910 |
Protein |
denotes |
NF-κB recognition sites |
| T16215 |
20931-20936 |
Protein |
denotes |
IL-17 |
| T16218 |
20950-20953 |
Protein |
denotes |
Fig |
| T16219 |
20981-20988 |
Protein |
denotes |
RA PBMC |
| T16225 |
20989-20999 |
Positive_regulation |
denotes |
stimulated |
| T16224 |
20989-20999 |
Positive_regulation |
denotes |
stimulated |
| T16220 |
21005-21013 |
Protein |
denotes |
anti-CD3 |
| T16221 |
21019-21028 |
Protein |
denotes |
anti-CD28 |
| T16229 |
21051-21060 |
Positive_regulation |
denotes |
increased |
| T16228 |
21051-21060 |
Positive_regulation |
denotes |
increased |
| T16227 |
21061-21068 |
Binding |
denotes |
binding |
| T16226 |
21061-21068 |
Binding |
denotes |
binding |
| T16222 |
21072-21077 |
Protein |
denotes |
NF-κB |
| T16223 |
21081-21096 |
Protein |
denotes |
IL-17 promoters |
| T16230 |
21192-21195 |
Protein |
denotes |
p65 |
| T16231 |
21200-21203 |
Protein |
denotes |
p50 |
| T16232 |
21307-21312 |
Protein |
denotes |
NF-κB |
| T16238 |
21313-21323 |
Positive_regulation |
denotes |
activation |
| T16237 |
21313-21323 |
Positive_regulation |
denotes |
activation |
| T16233 |
21327-21335 |
Protein |
denotes |
anti-CD3 |
| T16234 |
21341-21350 |
Protein |
denotes |
anti-CD28 |
| T16239 |
21360-21367 |
Binding |
denotes |
intense |
| T16235 |
21381-21388 |
Protein |
denotes |
RA PBMC |
| T16236 |
21390-21397 |
Protein |
denotes |
Fig. 7b |
| T16240 |
21428-21432 |
Protein |
denotes |
PI3K |
| T16241 |
21446-21451 |
Protein |
denotes |
NF-κB |
| T16242 |
21488-21493 |
Protein |
denotes |
NF-κB |
| T16243 |
21494-21501 |
Binding |
denotes |
binding |
| T16248 |
21568-21573 |
Negative_regulation |
denotes |
block |
| T16247 |
21568-21573 |
Negative_regulation |
denotes |
block |
| T16244 |
21574-21579 |
Protein |
denotes |
NF-κB |
| T16245 |
21608-21622 |
Protein |
denotes |
IL-17 promoter |
| T16246 |
21624-21631 |
Protein |
denotes |
Fig. 7c |
| T16249 |
21655-21660 |
Protein |
denotes |
IκB-α |
| T16253 |
21668-21678 |
Negative_regulation |
denotes |
inhibition |
| T16252 |
21682-21693 |
Protein_catabolism |
denotes |
degradation |
| T16250 |
21697-21702 |
Protein |
denotes |
IκB-α |
| T16251 |
21742-21749 |
Protein |
denotes |
Fig. 7c |
| T16254 |
21769-21773 |
Protein |
denotes |
AP-1 |
| T16255 |
21820-21828 |
Protein |
denotes |
anti-CD3 |
| T16256 |
21834-21843 |
Protein |
denotes |
anti-CD28 |
| T16257 |
21881-21886 |
Protein |
denotes |
NF-κB |
| T19621 |
22004-22009 |
Protein |
denotes |
IL-17 |
| T19622 |
22239-22243 |
Protein |
denotes |
IL-1 |
| T19623 |
22248-22253 |
Protein |
denotes |
TNF-α |
| T19624 |
22340-22344 |
Protein |
denotes |
IL-4 |
| T19625 |
22349-22361 |
Protein |
denotes |
interferon-γ |
| T19632 |
22975-22984 |
Positive_regulation |
denotes |
stimulate |
| T19626 |
22985-22990 |
Protein |
denotes |
IL-17 |
| T19630 |
22991-23001 |
Gene_expression |
denotes |
production |
| T19627 |
23039-23044 |
Protein |
denotes |
IL-17 |
| T19631 |
23045-23055 |
Gene_expression |
denotes |
production |
| T19628 |
23080-23083 |
Protein |
denotes |
CD3 |
| T19629 |
23089-23093 |
Protein |
denotes |
CD28 |
| T19633 |
23188-23191 |
Protein |
denotes |
CD3 |
| T19634 |
23192-23201 |
Protein |
denotes |
anti-CD28 |
| T19635 |
23228-23243 |
Protein |
denotes |
T cell receptor |
| T19637 |
23381-23393 |
Positive_regulation |
denotes |
upregulation |
| T19636 |
23397-23402 |
Protein |
denotes |
IL-17 |
| T19638 |
23486-23491 |
Protein |
denotes |
IL-17 |
| T19640 |
23495-23503 |
Gene_expression |
denotes |
produced |
| T19639 |
23524-23527 |
Protein |
denotes |
CD4 |
| T19641 |
23632-23636 |
Protein |
denotes |
CD8+ |
| T19645 |
23770-23779 |
Positive_regulation |
denotes |
augmented |
| T19644 |
23791-23802 |
Binding |
denotes |
recognizing |
| T19642 |
23803-23819 |
Protein |
denotes |
type II collagen |
| T19643 |
23825-23833 |
Protein |
denotes |
collagen |
| T19651 |
24095-24102 |
Localization |
denotes |
secrete |
| T19650 |
24095-24102 |
Localization |
denotes |
secrete |
| T19649 |
24095-24102 |
Localization |
denotes |
secrete |
| T19646 |
24129-24133 |
Protein |
denotes |
IL-6 |
| T19647 |
24135-24139 |
Protein |
denotes |
IL-8 |
| T19648 |
24144-24183 |
Protein |
denotes |
tumor necrosis factor-stimulated gene 6 |
| T19654 |
24288-24297 |
Positive_regulation |
denotes |
stimulate |
| T19652 |
24298-24303 |
Protein |
denotes |
IL-17 |
| T19653 |
24304-24314 |
Gene_expression |
denotes |
production |
| T19662 |
24457-24467 |
Gene_expression |
denotes |
production |
| T19661 |
24457-24467 |
Gene_expression |
denotes |
production |
| T19655 |
24471-24476 |
Protein |
denotes |
IL-17 |
| T19656 |
24480-24487 |
Protein |
denotes |
RA PBMC |
| T19657 |
24560-24575 |
Protein |
denotes |
T cell receptor |
| T19658 |
24577-24580 |
Protein |
denotes |
TCR |
| T19664 |
24582-24590 |
Binding |
denotes |
ligation |
| T19663 |
24582-24590 |
Binding |
denotes |
ligation |
| T19659 |
24602-24605 |
Protein |
denotes |
CD3 |
| T19660 |
24606-24615 |
Protein |
denotes |
anti-CD28 |
| T19665 |
24647-24652 |
Protein |
denotes |
IL-15 |
| T19666 |
24657-24662 |
Protein |
denotes |
MCP-1 |
| T19667 |
24674-24677 |
Protein |
denotes |
TCR |
| T19671 |
24678-24686 |
Binding |
denotes |
ligation |
| T19670 |
24678-24686 |
Binding |
denotes |
ligation |
| T19681 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19680 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19679 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19678 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19677 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19676 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19675 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19674 |
24701-24710 |
Positive_regulation |
denotes |
increased |
| T19673 |
24715-24725 |
Gene_expression |
denotes |
production |
| T19672 |
24715-24725 |
Gene_expression |
denotes |
production |
| T19668 |
24729-24734 |
Protein |
denotes |
IL-17 |
| T19669 |
24738-24745 |
Protein |
denotes |
RA PBMC |
| T19682 |
24754-24759 |
Protein |
denotes |
IL-15 |
| T19683 |
24763-24768 |
Protein |
denotes |
MCP-1 |
| T19684 |
24772-24775 |
Protein |
denotes |
TCR |
| T19685 |
24776-24784 |
Binding |
denotes |
ligation |
| T19686 |
24840-24844 |
Protein |
denotes |
IL-1 |
| T19687 |
24849-24854 |
Protein |
denotes |
TNF-α |
| T19691 |
24949-24955 |
Regulation |
denotes |
affect |
| T19690 |
24949-24955 |
Regulation |
denotes |
affect |
| T19688 |
24956-24961 |
Protein |
denotes |
IL-17 |
| T19689 |
24962-24972 |
Gene_expression |
denotes |
production |
| T19692 |
25025-25030 |
Protein |
denotes |
IL-15 |
| T19693 |
25080-25085 |
Protein |
denotes |
TNF-α |
| T19694 |
25359-25372 |
Protein |
denotes |
anti-CD3/anti |
| T19695 |
25373-25377 |
Protein |
denotes |
CD28 |
| T19701 |
25383-25392 |
Positive_regulation |
denotes |
increases |
| T19700 |
25383-25392 |
Positive_regulation |
denotes |
increases |
| T19696 |
25393-25398 |
Protein |
denotes |
IL-17 |
| T19699 |
25399-25408 |
Positive_regulation |
denotes |
induction |
| T19698 |
25399-25408 |
Positive_regulation |
denotes |
induction |
| T19697 |
25412-25419 |
Protein |
denotes |
RA PBMC |
| T19702 |
25497-25502 |
Protein |
denotes |
IL-17 |
| T19703 |
25576-25581 |
Protein |
denotes |
IL-17 |
| T19704 |
25582-25592 |
Gene_expression |
denotes |
production |
| T19705 |
25600-25609 |
Regulation |
denotes |
regulated |
| T19708 |
25755-25764 |
Positive_regulation |
denotes |
induction |
| T19706 |
25768-25773 |
Protein |
denotes |
IL-17 |
| T19707 |
25777-25784 |
Protein |
denotes |
RA PBMC |
| T19709 |
25810-25813 |
Protein |
denotes |
CD3 |
| T19716 |
25814-25821 |
Positive_regulation |
denotes |
induced |
| T19714 |
25828-25838 |
Gene_expression |
denotes |
production |
| T19710 |
25842-25849 |
Protein |
denotes |
RA PBMC |
| T19715 |
25868-25876 |
Positive_regulation |
denotes |
hampered |
| T19711 |
25884-25888 |
Protein |
denotes |
PI3K |
| T19712 |
25899-25907 |
Protein |
denotes |
LY294002 |
| T19713 |
25916-25921 |
Protein |
denotes |
NF-κB |
| T19717 |
26023-26026 |
Protein |
denotes |
CD3 |
| T19718 |
26101-26109 |
Protein |
denotes |
p38 MAPK |
| T19719 |
26110-26119 |
Negative_regulation |
denotes |
inhibitor |
| T19720 |
26192-26197 |
Protein |
denotes |
NF-κB |
| T19721 |
26202-26205 |
Protein |
denotes |
p38 |
| T19722 |
26220-26232 |
Protein |
denotes |
IκB kinase-β |
| T19727 |
26236-26245 |
Positive_regulation |
denotes |
activated |
| T19728 |
26267-26276 |
Positive_regulation |
denotes |
activated |
| T19723 |
26277-26280 |
Protein |
denotes |
p38 |
| T19729 |
26285-26294 |
Positive_regulation |
denotes |
stimulate |
| T19724 |
26295-26300 |
Protein |
denotes |
NF-κB |
| T19725 |
26326-26348 |
Protein |
denotes |
histone acetylase p300 |
| T19726 |
26349-26353 |
Protein |
denotes |
CREB |
| T19730 |
26354-26361 |
Binding |
denotes |
binding |
| T19731 |
26402-26410 |
Protein |
denotes |
p38 MAPK |
| T19735 |
26411-26421 |
Positive_regulation |
denotes |
activation |
| T19736 |
26430-26438 |
Regulation |
denotes |
affected |
| T19732 |
26460-26465 |
Protein |
denotes |
NF-κB |
| T19737 |
26466-26473 |
Binding |
denotes |
binding |
| T19738 |
26487-26496 |
Negative_regulation |
denotes |
decreased |
| T19733 |
26544-26547 |
Protein |
denotes |
p38 |
| T19734 |
26576-26580 |
Protein |
denotes |
PI3K |
| T19739 |
26581-26591 |
Positive_regulation |
denotes |
activation |
| T19740 |
26625-26628 |
Protein |
denotes |
p38 |
| T19741 |
26633-26638 |
Protein |
denotes |
NF-κB |
| T19742 |
26643-26648 |
Protein |
denotes |
IL-17 |
| T19743 |
26649-26659 |
Gene_expression |
denotes |
production |
| T19744 |
26742-26746 |
Protein |
denotes |
PI3K |
| T19745 |
26784-26787 |
Protein |
denotes |
Akt |
| T19746 |
26788-26798 |
Positive_regulation |
denotes |
activation |
| T19747 |
26823-26827 |
Negative_regulation |
denotes |
loss |
| T19748 |
26866-26869 |
Protein |
denotes |
Akt |
| T19752 |
26873-26887 |
Phosphorylation |
denotes |
phosphorylated |
| T19749 |
26898-26901 |
Protein |
denotes |
CD3 |
| T19754 |
26936-26947 |
Regulation |
denotes |
involvement |
| T19750 |
26951-26955 |
Protein |
denotes |
PI3K |
| T19753 |
26963-26972 |
Positive_regulation |
denotes |
induction |
| T19751 |
26976-26981 |
Protein |
denotes |
IL-17 |
| T19755 |
27014-27019 |
Protein |
denotes |
NF-κB |
| T19764 |
27029-27038 |
Positive_regulation |
denotes |
activated |
| T19763 |
27029-27038 |
Positive_regulation |
denotes |
activated |
| T19762 |
27029-27038 |
Positive_regulation |
denotes |
activated |
| T19756 |
27042-27050 |
Protein |
denotes |
anti-CD3 |
| T19757 |
27051-27060 |
Protein |
denotes |
anti-CD28 |
| T19758 |
27062-27067 |
Protein |
denotes |
IL-15 |
| T19759 |
27127-27132 |
Protein |
denotes |
NF-κB |
| T19768 |
27158-27166 |
Regulation |
denotes |
involved |
| T19767 |
27158-27166 |
Regulation |
denotes |
involved |
| T19766 |
27174-27183 |
Positive_regulation |
denotes |
induction |
| T19765 |
27174-27183 |
Positive_regulation |
denotes |
induction |
| T19760 |
27187-27192 |
Protein |
denotes |
IL-17 |
| T19761 |
27196-27203 |
Protein |
denotes |
RA PBMC |
| T19769 |
27222-27226 |
Protein |
denotes |
AP-1 |
| T19770 |
27382-27386 |
Protein |
denotes |
PI3K |
| T19771 |
27413-27416 |
Protein |
denotes |
Akt |
| T19775 |
27420-27431 |
Binding |
denotes |
association |
| T19774 |
27420-27431 |
Binding |
denotes |
association |
| T19772 |
27437-27442 |
Protein |
denotes |
NF-κB |
| T19773 |
27544-27549 |
Protein |
denotes |
IL-17 |
| T19776 |
27598-27602 |
Protein |
denotes |
PI3K |
| T19777 |
27603-27606 |
Protein |
denotes |
Akt |
| T19778 |
27621-27626 |
Protein |
denotes |
NF-κB |
| T19781 |
27627-27637 |
Positive_regulation |
denotes |
activation |
| T19789 |
27760-27768 |
Negative_regulation |
denotes |
blocking |
| T19788 |
27760-27768 |
Negative_regulation |
denotes |
blocking |
| T19787 |
27760-27768 |
Negative_regulation |
denotes |
blocking |
| T19786 |
27760-27768 |
Negative_regulation |
denotes |
blocking |
| T19779 |
27772-27777 |
Protein |
denotes |
NF-κB |
| T19785 |
27778-27785 |
Binding |
denotes |
binding |
| T19784 |
27778-27785 |
Binding |
denotes |
binding |
| T19783 |
27778-27785 |
Binding |
denotes |
binding |
| T19782 |
27778-27785 |
Binding |
denotes |
binding |
| T19780 |
27802-27816 |
Protein |
denotes |
IL-17 promoter |
| T19792 |
27897-27906 |
Positive_regulation |
denotes |
induction |
| T19790 |
27910-27920 |
Protein |
denotes |
anti-IL-17 |
| T19791 |
27996-28001 |
Protein |
denotes |
IL-17 |
| T22374 |
28136-28146 |
Gene_expression |
denotes |
production |
| T22373 |
28136-28146 |
Gene_expression |
denotes |
production |
| T22367 |
28150-28155 |
Protein |
denotes |
IL-17 |
| T22368 |
28161-28168 |
Protein |
denotes |
RA PBMC |
| T22376 |
28172-28180 |
Positive_regulation |
denotes |
response |
| T22375 |
28172-28180 |
Positive_regulation |
denotes |
response |
| T22369 |
28184-28189 |
Protein |
denotes |
IL-15 |
| T22370 |
28194-28199 |
Protein |
denotes |
MCP-1 |
| T22371 |
28226-28234 |
Protein |
denotes |
anti-CD3 |
| T22372 |
28235-28244 |
Protein |
denotes |
anti-CD28 |
| T22381 |
28270-28282 |
Positive_regulation |
denotes |
upregulation |
| T22377 |
28286-28291 |
Protein |
denotes |
IL-17 |
| T22378 |
28375-28379 |
Protein |
denotes |
PI3K |
| T22379 |
28380-28383 |
Protein |
denotes |
Akt |
| T22380 |
28407-28412 |
Protein |
denotes |
NF-κB |
| T22382 |
28413-28423 |
Positive_regulation |
denotes |
activation |
| T22384 |
28654-28666 |
Gene_expression |
denotes |
introduction |
| T22383 |
28670-28680 |
Protein |
denotes |
anti-IL-17 |
| R10483 |
T19626 |
T19630 |
themeOf |
IL-17,production |
| R10484 |
T19627 |
T19631 |
themeOf |
IL-17,production |
| R10485 |
T19630 |
T19632 |
themeOf |
production,stimulate |
| R10486 |
T19636 |
T19637 |
themeOf |
IL-17,upregulation |
| R10487 |
T19638 |
T19640 |
themeOf |
IL-17,produced |
| R10488 |
T19642 |
T19644 |
themeOf |
type II collagen,recognizing |
| R10489 |
T19644 |
T19645 |
themeOf |
recognizing,augmented |
| R10490 |
T19646 |
T19649 |
themeOf |
IL-6,secrete |
| R10491 |
T19647 |
T19650 |
themeOf |
IL-8,secrete |
| R10492 |
T19648 |
T19651 |
themeOf |
tumor necrosis factor-stimulated gene 6,secrete |
| R10493 |
T19652 |
T19653 |
themeOf |
IL-17,production |
| R10494 |
T19653 |
T19654 |
themeOf |
production,stimulate |
| R10495 |
T19655 |
T19661 |
themeOf |
IL-17,production |
| R10496 |
T19656 |
T19662 |
themeOf |
RA PBMC,production |
| R10497 |
T19657 |
T19663 |
themeOf |
T cell receptor,ligation |
| R10498 |
T19658 |
T19664 |
themeOf |
TCR,ligation |
| R10499 |
T19665 |
T19671 |
themeOf |
IL-15,ligation |
| R10500 |
T19665 |
T19674 |
causeOf |
IL-15,increased |
| R10501 |
T19665 |
T19675 |
causeOf |
IL-15,increased |
| R10502 |
T19666 |
T19676 |
causeOf |
MCP-1,increased |
| R10503 |
T19666 |
T19677 |
causeOf |
MCP-1,increased |
| R10504 |
T19667 |
T19670 |
themeOf |
TCR,ligation |
| R10505 |
T19667 |
T19671 |
themeOf |
TCR,ligation |
| R10506 |
T19668 |
T19672 |
themeOf |
IL-17,production |
| R10507 |
T19669 |
T19673 |
themeOf |
RA PBMC,production |
| R10508 |
T19670 |
T19678 |
causeOf |
ligation,increased |
| R10509 |
T19670 |
T19679 |
causeOf |
ligation,increased |
| R10510 |
T19671 |
T19680 |
causeOf |
ligation,increased |
| R10511 |
T19671 |
T19681 |
causeOf |
ligation,increased |
| R10512 |
T19672 |
T19674 |
themeOf |
production,increased |
| R10513 |
T19672 |
T19676 |
themeOf |
production,increased |
| R10514 |
T19672 |
T19678 |
themeOf |
production,increased |
| R10515 |
T19672 |
T19680 |
themeOf |
production,increased |
| R10516 |
T19673 |
T19675 |
themeOf |
production,increased |
| R10517 |
T19673 |
T19677 |
themeOf |
production,increased |
| R10518 |
T19673 |
T19679 |
themeOf |
production,increased |
| R10519 |
T19673 |
T19681 |
themeOf |
production,increased |
| R10520 |
T19684 |
T19685 |
themeOf |
TCR,ligation |
| R10521 |
T19686 |
T19690 |
causeOf |
IL-1,affect |
| R10522 |
T19687 |
T19691 |
causeOf |
TNF-α,affect |
| R10523 |
T19688 |
T19689 |
themeOf |
IL-17,production |
| R10524 |
T19689 |
T19690 |
themeOf |
production,affect |
| R10525 |
T19689 |
T19691 |
themeOf |
production,affect |
| R10526 |
T19696 |
T19698 |
themeOf |
IL-17,induction |
| R10527 |
T19697 |
T19699 |
themeOf |
RA PBMC,induction |
| R10528 |
T19698 |
T19700 |
themeOf |
induction,increases |
| R10529 |
T19699 |
T19701 |
themeOf |
induction,increases |
| R10530 |
T19703 |
T19704 |
themeOf |
IL-17,production |
| R10531 |
T19704 |
T19705 |
themeOf |
production,regulated |
| R10532 |
T19707 |
T19708 |
themeOf |
RA PBMC,induction |
| R10533 |
T19709 |
T19716 |
causeOf |
CD3,induced |
| R10534 |
T19710 |
T19714 |
themeOf |
RA PBMC,production |
| R10535 |
T19712 |
T19715 |
causeOf |
LY294002,hampered |
| R10536 |
T19714 |
T19715 |
themeOf |
production,hampered |
| R10537 |
T19714 |
T19716 |
themeOf |
production,induced |
| R10538 |
T19718 |
T19719 |
themeOf |
p38 MAPK,inhibitor |
| R10539 |
T19722 |
T19727 |
themeOf |
IκB kinase-β,activated |
| R10540 |
T19723 |
T19728 |
themeOf |
p38,activated |
| R10541 |
T19724 |
T19729 |
themeOf |
NF-κB,stimulate |
| R10542 |
T19726 |
T19730 |
themeOf |
CREB,binding |
| R10543 |
T19728 |
T19729 |
causeOf |
activated,stimulate |
| R10544 |
T19731 |
T19735 |
themeOf |
p38 MAPK,activation |
| R10545 |
T19732 |
T19737 |
themeOf |
NF-κB,binding |
| R10546 |
T19734 |
T19739 |
themeOf |
PI3K,activation |
| R10547 |
T19735 |
T19736 |
themeOf |
activation,affected |
| R10548 |
T19737 |
T19738 |
themeOf |
binding,decreased |
| R10549 |
T19742 |
T19743 |
themeOf |
IL-17,production |
| R10550 |
T19745 |
T19746 |
themeOf |
Akt,activation |
| R10551 |
T19746 |
T19747 |
themeOf |
activation,loss |
| R10552 |
T19748 |
T19752 |
themeOf |
Akt,phosphorylated |
| R10553 |
T19750 |
T19754 |
causeOf |
PI3K,involvement |
| R10554 |
T19751 |
T19753 |
themeOf |
IL-17,induction |
| R10555 |
T19753 |
T19754 |
themeOf |
induction,involvement |
| R10556 |
T19755 |
T19762 |
themeOf |
NF-κB,activated |
| R10557 |
T19755 |
T19763 |
themeOf |
NF-κB,activated |
| R10558 |
T19755 |
T19764 |
themeOf |
NF-κB,activated |
| R10559 |
T19756 |
T19762 |
causeOf |
anti-CD3,activated |
| R10560 |
T19757 |
T19763 |
causeOf |
anti-CD28,activated |
| R10561 |
T19758 |
T19764 |
causeOf |
IL-15,activated |
| R10562 |
T19759 |
T19767 |
causeOf |
NF-κB,involved |
| R10563 |
T19759 |
T19768 |
causeOf |
NF-κB,involved |
| R10564 |
T19760 |
T19765 |
themeOf |
IL-17,induction |
| R10565 |
T19761 |
T19766 |
themeOf |
RA PBMC,induction |
| R10566 |
T19765 |
T19767 |
themeOf |
induction,involved |
| R10567 |
T19766 |
T19768 |
themeOf |
induction,involved |
| R10568 |
T19771 |
T19775 |
themeOf |
Akt,association |
| R10569 |
T19772 |
T19774 |
themeOf |
NF-κB,association |
| R10570 |
T19772 |
T19775 |
themeOf |
NF-κB,association |
| R10571 |
T19777 |
T19784 |
themeOf |
Akt,binding |
| R10572 |
T19778 |
T19781 |
themeOf |
NF-κB,activation |
| R10573 |
T19779 |
T19782 |
themeOf |
NF-κB,binding |
| R10574 |
T19779 |
T19784 |
themeOf |
NF-κB,binding |
| R10575 |
T19779 |
T19785 |
themeOf |
NF-κB,binding |
| R10576 |
T19780 |
T19783 |
themeOf |
IL-17 promoter,binding |
| R10577 |
T19780 |
T19785 |
themeOf |
IL-17 promoter,binding |
| R10578 |
T19782 |
T19786 |
themeOf |
binding,blocking |
| R10579 |
T19783 |
T19787 |
themeOf |
binding,blocking |
| R10580 |
T19784 |
T19788 |
themeOf |
binding,blocking |
| R10581 |
T19785 |
T19789 |
themeOf |
binding,blocking |
| R10582 |
T19790 |
T19792 |
themeOf |
anti-IL-17,induction |
| R12199 |
T22367 |
T22373 |
themeOf |
IL-17,production |
| R12200 |
T22368 |
T22374 |
themeOf |
RA PBMC,production |
| R12201 |
T22369 |
T22375 |
themeOf |
IL-15,response |
| R12202 |
T22370 |
T22376 |
themeOf |
MCP-1,response |
| R12203 |
T22377 |
T22381 |
themeOf |
IL-17,upregulation |
| R12204 |
T22380 |
T22382 |
themeOf |
NF-κB,activation |
| R12205 |
T22383 |
T22384 |
themeOf |
anti-IL-17,introduction |
| R1751 |
T3601 |
T3603 |
themeOf |
tumor necrosis factor (TNF)-α,inhibitors |
| R1753 |
T3602 |
T3604 |
themeOf |
interleukin (IL)-1,inhibitors |
| R1754 |
T3607 |
T3613 |
themeOf |
IL-1,abundant |
| R1757 |
T3608 |
T3614 |
themeOf |
IL-6,abundant |
| R1758 |
T3609 |
T3615 |
themeOf |
IL-15,abundant |
| R1759 |
T3610 |
T3616 |
themeOf |
IL-18,abundant |
| R1760 |
T3611 |
T3617 |
themeOf |
TNF-α,abundant |
| R1761 |
T3612 |
T3618 |
themeOf |
rheumatoid synovium,abundant |
| R1762 |
T3620 |
T3623 |
themeOf |
IL-17,secreted |
| R1763 |
T3620 |
T3626 |
causeOf |
IL-17,induce |
| R1764 |
T3620 |
T3627 |
causeOf |
IL-17,induce |
| R1765 |
T3621 |
T3624 |
themeOf |
IL-6,secreted |
| R1766 |
T3621 |
T3626 |
themeOf |
IL-6,induce |
| R1767 |
T3622 |
T3625 |
themeOf |
IL-8,secreted |
| R1768 |
T3622 |
T3627 |
themeOf |
IL-8,induce |
| R1769 |
T3633 |
T3634 |
themeOf |
IL-6,production |
| R1770 |
T3634 |
T3635 |
themeOf |
production,stimulates |
| R1771 |
T3636 |
T3638 |
themeOf |
IL-17,Levels |
| R1772 |
T3638 |
T3639 |
themeOf |
Levels,higher |
| R1773 |
T3640 |
T3641 |
themeOf |
IL-15,secreted |
| R1774 |
T3645 |
T3646 |
themeOf |
IL-17,production |
| R1775 |
T3651 |
T3652 |
themeOf |
cytokine IL-17,overproduction |
| R2966 |
T5569 |
T5571 |
themeOf |
Phytohemagglutinin,obtained |
| R2967 |
T5570 |
T5572 |
themeOf |
PHA,obtained |
| R4481 |
T8696 |
T8697 |
themeOf |
GAPDH,product |
| R481 |
T1142 |
T1144 |
themeOf |
phosphoinositide 3-kinase,production |
| R482 |
T1143 |
T1145 |
themeOf |
Akt,production |
| R483 |
T1144 |
T1146 |
themeOf |
production,Increased |
| R484 |
T1145 |
T1147 |
themeOf |
production,Increased |
| R485 |
T1149 |
T1150 |
themeOf |
IL-17,expression |
| R486 |
T1151 |
T1152 |
themeOf |
IL-17,production |
| R487 |
T1152 |
T1153 |
themeOf |
production,regulate |
| R488 |
T1157 |
T1158 |
themeOf |
IL-17,production |
| R489 |
T1158 |
T1159 |
themeOf |
production,regulation |
| R490 |
T1159 |
T1160 |
themeOf |
regulation,role |
| R491 |
T1166 |
T1170 |
themeOf |
IL-17,production |
| R492 |
T1170 |
T1171 |
themeOf |
production,increased |
| R493 |
T1172 |
T1179 |
causeOf |
"IL-15, monocyte chemoattractant protein-1",upregulated |
| R494 |
T1173 |
T1180 |
causeOf |
IL-6,upregulated |
| R495 |
T1174 |
T1178 |
themeOf |
IL-17,production |
| R496 |
T1178 |
T1179 |
themeOf |
production,upregulated |
| R497 |
T1178 |
T1180 |
themeOf |
production,upregulated |
| R498 |
T1181 |
T1183 |
themeOf |
IL-17,detected |
| R499 |
T1182 |
T1184 |
themeOf |
RA PBMC,expression |
| R500 |
T1185 |
T1190 |
causeOf |
Anti-CD3 antibody,activated |
| R501 |
T1186 |
T1190 |
themeOf |
PI3K,activated |
| R502 |
T1188 |
T1191 |
themeOf |
nuclear factor κB,augmentation |
| R503 |
T1189 |
T1192 |
themeOf |
NF-κB,augmentation |
| R504 |
T1193 |
T1197 |
themeOf |
RA PBMC,production |
| R505 |
T1193 |
T1198 |
themeOf |
RA PBMC,activated |
| R506 |
T1195 |
T1201 |
themeOf |
PI3K,inhibitor |
| R5066 |
T9629 |
T9631 |
themeOf |
Akt,phosphorylated |
| R5067 |
T9632 |
T9635 |
themeOf |
Akt,phosphorylated |
| R5068 |
T9633 |
T9636 |
themeOf |
Akt,phosphorylated |
| R5069 |
T9634 |
T9637 |
themeOf |
IκB-α,phosphorylated |
| R507 |
T1196 |
T1202 |
themeOf |
Akt,inhibitor |
| R508 |
T1197 |
T1199 |
themeOf |
production,activated |
| R509 |
T1197 |
T1200 |
themeOf |
production,blocked |
| R510 |
T1203 |
T1206 |
themeOf |
activator protein-1,inhibition |
| R511 |
T1204 |
T1207 |
themeOf |
extracellular signal-regulated kinase 1/2,inhibition |
| R512 |
T1205 |
T1208 |
themeOf |
IL-17,production |
| R513 |
T1206 |
T1209 |
causeOf |
inhibition,affect |
| R514 |
T1207 |
T1210 |
causeOf |
inhibition,affect |
| R515 |
T1208 |
T1209 |
themeOf |
production,affect |
| R516 |
T1208 |
T1210 |
themeOf |
production,affect |
| R517 |
T1214 |
T1215 |
themeOf |
cytokine IL-17,overproduction |
| R6145 |
T11390 |
T11392 |
themeOf |
IL-17,production |
| R6146 |
T11392 |
T11393 |
themeOf |
production,stimulated |
| R6497 |
T11980 |
T11982 |
themeOf |
CD3,production |
| R6498 |
T11981 |
T11983 |
themeOf |
CD28,production |
| R6499 |
T11982 |
T11984 |
themeOf |
production,Increased |
| R6500 |
T11983 |
T11985 |
themeOf |
production,Increased |
| R6501 |
T11986 |
T11988 |
themeOf |
IL-17,produced |
| R6502 |
T11987 |
T11989 |
themeOf |
IL-17,increase |
| R6503 |
T11992 |
T12001 |
causeOf |
anti-CD3,upregulated |
| R6504 |
T11993 |
T11998 |
themeOf |
IL-17,production |
| R6505 |
T11996 |
T11999 |
themeOf |
more IL-17,produced |
| R6506 |
T11997 |
T12000 |
themeOf |
CD3,produced |
| R6507 |
T11998 |
T12001 |
themeOf |
production,upregulated |
| R6508 |
T12003 |
T12006 |
themeOf |
IL-17,production |
| R6509 |
T12004 |
T12007 |
themeOf |
anti-CD3,than |
| R6510 |
T12006 |
T12008 |
themeOf |
production,increased |
| R6980 |
T12874 |
T12875 |
themeOf |
IL-17,production |
| R6981 |
T12875 |
T12876 |
themeOf |
production,Regulation |
| R6982 |
T12879 |
T12884 |
themeOf |
IL-1β,unchanged |
| R6983 |
T12879 |
T12886 |
themeOf |
IL-1β,unchanged |
| R6984 |
T12879 |
T12888 |
themeOf |
IL-1β,unchanged |
| R6985 |
T12880 |
T12884 |
causeOf |
TNF-α,unchanged |
| R6986 |
T12880 |
T12885 |
causeOf |
TNF-α,unchanged |
| R6987 |
T12881 |
T12886 |
causeOf |
IL-18,unchanged |
| R6988 |
T12881 |
T12887 |
causeOf |
IL-18,unchanged |
| R6989 |
T12882 |
T12888 |
causeOf |
TGF-β,unchanged |
| R6990 |
T12882 |
T12889 |
causeOf |
TGF-β,unchanged |
| R6991 |
T12883 |
T12885 |
themeOf |
Fig. 2a,unchanged |
| R6992 |
T12883 |
T12887 |
themeOf |
Fig. 2a,unchanged |
| R6993 |
T12883 |
T12889 |
themeOf |
Fig. 2a,unchanged |
| R6994 |
T12891 |
T12895 |
themeOf |
IL-17 proteins,upregulations |
| R7557 |
T13877 |
T13878 |
themeOf |
IL-17,production |
| R7558 |
T13878 |
T13879 |
themeOf |
production,Inhibition |
| R7559 |
T13882 |
T13884 |
themeOf |
NF-κB,inhibitor |
| R7560 |
T13885 |
T13887 |
themeOf |
PI3K,inhibitor |
| R7561 |
T13888 |
T13894 |
themeOf |
calcineurin,inhibitors |
| R7562 |
T13889 |
T13897 |
themeOf |
IL-17,secretion |
| R7563 |
T13890 |
T13895 |
themeOf |
mitogen-activated protein kinase,downregulated |
| R7564 |
T13890 |
T13898 |
themeOf |
mitogen-activated protein kinase,secretion |
| R7565 |
T13890 |
T13901 |
themeOf |
mitogen-activated protein kinase,inhibitor |
| R7566 |
T13891 |
T13899 |
themeOf |
MAPK,secretion |
| R7567 |
T13891 |
T13902 |
themeOf |
MAPK,inhibitor |
| R7568 |
T13892 |
T13896 |
themeOf |
p38,downregulated |
| R7569 |
T13892 |
T13900 |
themeOf |
p38,secretion |
| R7570 |
T13892 |
T13903 |
themeOf |
p38,inhibitor |
| R7571 |
T13893 |
T13908 |
themeOf |
IL-17,effect |
| R7572 |
T13894 |
T13895 |
causeOf |
inhibitors,downregulated |
| R7573 |
T13894 |
T13896 |
causeOf |
inhibitors,downregulated |
| R7574 |
T13894 |
T13909 |
causeOf |
inhibitors,downregulated |
| R7575 |
T13894 |
T13910 |
causeOf |
inhibitors,downregulated |
| R7576 |
T13894 |
T13911 |
causeOf |
inhibitors,downregulated |
| R7577 |
T13894 |
T13912 |
causeOf |
inhibitors,downregulated |
| R7578 |
T13897 |
T13904 |
themeOf |
secretion,inhibitor |
| R7579 |
T13897 |
T13909 |
themeOf |
secretion,downregulated |
| R7580 |
T13898 |
T13905 |
themeOf |
secretion,inhibitor |
| R7581 |
T13898 |
T13910 |
themeOf |
secretion,downregulated |
| R7582 |
T13899 |
T13906 |
themeOf |
secretion,inhibitor |
| R7583 |
T13899 |
T13911 |
themeOf |
secretion,downregulated |
| R7584 |
T13900 |
T13907 |
themeOf |
secretion,inhibitor |
| R7585 |
T13900 |
T13912 |
themeOf |
secretion,downregulated |
| R7586 |
T13913 |
T13914 |
themeOf |
IL-17,production |
| R7587 |
T13914 |
T13915 |
themeOf |
production,inhibition |
| R7588 |
T13917 |
T13918 |
themeOf |
Fig. 4b,effects |
| R8323 |
T15147 |
T15149 |
themeOf |
PI3K,Activation |
| R8324 |
T15148 |
T15150 |
themeOf |
Akt,Activation |
| R8325 |
T15152 |
T15153 |
themeOf |
Akt,activation |
| R8326 |
T15155 |
T15156 |
themeOf |
Akt,phosphorylated |
| R8327 |
T15157 |
T15159 |
themeOf |
Akt,non-phosphorylated |
| R8328 |
T15158 |
T15160 |
themeOf |
β-actin,non-phosphorylated |
| R8329 |
T15164 |
T15166 |
themeOf |
Akt,phosphorylated |
| R8837 |
T16201 |
T16205 |
themeOf |
NF-κB,Activation |
| R8838 |
T16202 |
T16206 |
themeOf |
activator protein-1,Activation |
| R8839 |
T16203 |
T16207 |
themeOf |
AP-1,Activation |
| R8840 |
T16213 |
T16216 |
themeOf |
IL-17,expression |
| R8841 |
T16216 |
T16217 |
themeOf |
expression,inducing |
| R8842 |
T16219 |
T16224 |
themeOf |
RA PBMC,stimulated |
| R8843 |
T16220 |
T16225 |
themeOf |
anti-CD3,stimulated |
| R8844 |
T16221 |
T16224 |
causeOf |
anti-CD28,stimulated |
| R8845 |
T16221 |
T16225 |
causeOf |
anti-CD28,stimulated |
| R8846 |
T16222 |
T16226 |
themeOf |
NF-κB,binding |
| R8847 |
T16222 |
T16227 |
themeOf |
NF-κB,binding |
| R8848 |
T16223 |
T16227 |
themeOf |
IL-17 promoters,binding |
| R8849 |
T16226 |
T16228 |
themeOf |
binding,increased |
| R8850 |
T16227 |
T16229 |
themeOf |
binding,increased |
| R8851 |
T16232 |
T16237 |
themeOf |
NF-κB,activation |
| R8852 |
T16232 |
T16238 |
themeOf |
NF-κB,activation |
| R8853 |
T16233 |
T16237 |
causeOf |
anti-CD3,activation |
| R8854 |
T16234 |
T16238 |
causeOf |
anti-CD28,activation |
| R8855 |
T16235 |
T16239 |
themeOf |
RA PBMC,intense |
| R8856 |
T16242 |
T16243 |
themeOf |
NF-κB,binding |
| R8857 |
T16245 |
T16247 |
themeOf |
IL-17 promoter,block |
| R8858 |
T16246 |
T16248 |
themeOf |
Fig. 7c,block |
| R8859 |
T16250 |
T16252 |
themeOf |
IκB-α,degradation |
| R8860 |
T16252 |
T16253 |
themeOf |
degradation,inhibition |
