| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1089 |
14-19 |
Protein |
denotes |
IL-10 |
| T1093 |
20-30 |
Negative_regulation |
denotes |
inhibition |
| T1090 |
34-50 |
Protein |
denotes |
interferon gamma |
| T1092 |
51-61 |
Gene_expression |
denotes |
production |
| T1091 |
118-121 |
Protein |
denotes |
CD4 |
| T1094 |
181-186 |
Protein |
denotes |
IL-10 |
| T1096 |
260-270 |
Negative_regulation |
denotes |
inhibiting |
| T1095 |
275-279 |
Protein |
denotes |
CD28 |
| T1097 |
330-334 |
Protein |
denotes |
CD4+ |
| T1103 |
408-415 |
Gene_expression |
denotes |
produce |
| T1104 |
408-415 |
Gene_expression |
denotes |
produce |
| T1105 |
424-431 |
Gene_expression |
denotes |
amounts |
| T1098 |
435-451 |
Protein |
denotes |
interferon gamma |
| T1099 |
458-461 |
Protein |
denotes |
CD3 |
| T1100 |
466-470 |
Protein |
denotes |
CD28 |
| T1101 |
543-547 |
Protein |
denotes |
CD4+ |
| T1106 |
580-590 |
Gene_expression |
denotes |
expression |
| T1102 |
598-619 |
Protein |
denotes |
type 1 IL-10 receptor |
| T1107 |
624-633 |
Positive_regulation |
denotes |
increased |
| T1108 |
943-946 |
Protein |
denotes |
CD4 |
| T1109 |
1000-1018 |
Protein |
denotes |
anti-IL-6 antibody |
| T1110 |
1044-1048 |
Protein |
denotes |
CD4+ |
| T1111 |
1062-1066 |
Protein |
denotes |
IL-6 |
| T1116 |
1067-1074 |
Negative_regulation |
denotes |
reduced |
| T1112 |
1075-1080 |
Protein |
denotes |
IL-10 |
| T1115 |
1090-1100 |
Negative_regulation |
denotes |
inhibition |
| T1113 |
1104-1120 |
Protein |
denotes |
interferon gamma |
| T1114 |
1121-1131 |
Gene_expression |
denotes |
production |
| T1117 |
1139-1143 |
Protein |
denotes |
CD4+ |
| T1118 |
1251-1290 |
Protein |
denotes |
suppressor of cytokine signaling 3 mRNA |
| T1119 |
1313-1317 |
Protein |
denotes |
CD4+ |
| T1120 |
1390-1393 |
Protein |
denotes |
CD4 |
| T1121 |
1518-1523 |
Protein |
denotes |
IL-10 |
| T3705 |
1693-1698 |
Protein |
denotes |
IL-10 |
| T3706 |
1834-1839 |
Protein |
denotes |
IL-10 |
| T3713 |
1840-1845 |
Binding |
denotes |
binds |
| T3712 |
1840-1845 |
Binding |
denotes |
binds |
| T3711 |
1840-1845 |
Binding |
denotes |
binds |
| T3707 |
1853-1867 |
Protein |
denotes |
IL-10 receptor |
| T3708 |
1869-1875 |
Protein |
denotes |
IL-10R |
| T3715 |
1931-1945 |
Binding |
denotes |
ligand-binding |
| T3714 |
1931-1945 |
Binding |
denotes |
ligand-binding |
| T3709 |
1956-1969 |
Protein |
denotes |
type 1 IL-10R |
| T3710 |
1971-1978 |
Protein |
denotes |
IL-10R1 |
| T3716 |
2046-2051 |
Protein |
denotes |
IL-10 |
| T3717 |
2056-2062 |
Protein |
denotes |
IL-10R |
| T3718 |
2075-2087 |
Protein |
denotes |
Janus kinase |
| T3719 |
2089-2092 |
Protein |
denotes |
JAK |
| T3720 |
2094-2117 |
Protein |
denotes |
family tyrosine kinases |
| T3721 |
2118-2122 |
Protein |
denotes |
Jak1 |
| T3722 |
2127-2131 |
Protein |
denotes |
Tyk2 |
| T3723 |
2174-2181 |
Protein |
denotes |
IL-10R1 |
| T3724 |
2186-2199 |
Protein |
denotes |
type 2 IL-10R |
| T3725 |
2219-2224 |
Protein |
denotes |
IL-10 |
| T3729 |
2225-2232 |
Positive_regulation |
denotes |
induces |
| T3727 |
2233-2241 |
Entity |
denotes |
tyrosine |
| T3728 |
2262-2272 |
Positive_regulation |
denotes |
activation |
| T3726 |
2280-2310 |
Protein |
denotes |
latent transcriptional factors |
| T3733 |
2389-2404 |
Phosphorylation |
denotes |
phosphorylation |
| T3732 |
2389-2404 |
Phosphorylation |
denotes |
phosphorylation |
| T3730 |
2406-2411 |
Protein |
denotes |
STAT1 |
| T3731 |
2416-2430 |
Protein |
denotes |
STAT3 proteins |
| T3736 |
2472-2483 |
Localization |
denotes |
translocate |
| T3735 |
2472-2483 |
Localization |
denotes |
translocate |
| T3734 |
2493-2500 |
Entity |
denotes |
nucleus |
| T3737 |
2549-2554 |
Protein |
denotes |
STAT3 |
| T3738 |
2691-2696 |
Protein |
denotes |
STAT3 |
| T3741 |
2697-2706 |
Negative_regulation |
denotes |
deficient |
| T3739 |
2728-2733 |
Protein |
denotes |
STAT3 |
| T3742 |
2734-2744 |
Positive_regulation |
denotes |
activation |
| T3740 |
2762-2767 |
Protein |
denotes |
IL-10 |
| T3743 |
2936-2970 |
Protein |
denotes |
cytokine signaling (SOCS) proteins |
| T3744 |
3018-3028 |
Protein |
denotes |
JAK kinase |
| T3745 |
3029-3039 |
Negative_regulation |
denotes |
inhibitors |
| T3746 |
3242-3247 |
Protein |
denotes |
SOCS3 |
| T3752 |
3268-3278 |
Regulation |
denotes |
regulating |
| T3751 |
3268-3278 |
Regulation |
denotes |
regulating |
| T3747 |
3303-3308 |
Protein |
denotes |
IL-10 |
| T3748 |
3313-3317 |
Protein |
denotes |
IL-6 |
| T3749 |
3344-3349 |
Protein |
denotes |
STAT3 |
| T3750 |
3372-3376 |
Protein |
denotes |
IL-6 |
| T3753 |
3807-3834 |
Protein |
denotes |
Tumor necrosis factor alpha |
| T3754 |
3836-3841 |
Protein |
denotes |
TNF-α |
| T3755 |
3847-3851 |
Protein |
denotes |
IL-1 |
| T3756 |
4135-4139 |
Protein |
denotes |
IL-6 |
| T3757 |
4166-4174 |
Gene_expression |
denotes |
produced |
| T3758 |
4514-4519 |
Protein |
denotes |
IL-10 |
| T3759 |
4521-4529 |
Gene_expression |
denotes |
produced |
| T3760 |
4672-4682 |
Gene_expression |
denotes |
expression |
| T3761 |
4812-4817 |
Protein |
denotes |
IL-10 |
| T3762 |
4832-4841 |
Positive_regulation |
denotes |
modulated |
| T3763 |
4907-4912 |
Protein |
denotes |
IL-10 |
| T3764 |
5009-5014 |
Protein |
denotes |
TNF-α |
| T3765 |
5019-5023 |
Protein |
denotes |
IL-1 |
| T3769 |
5067-5077 |
Gene_expression |
denotes |
expression |
| T3766 |
5081-5088 |
Protein |
denotes |
IL-10R1 |
| T3770 |
5092-5101 |
Negative_regulation |
denotes |
decreased |
| T3767 |
5159-5164 |
Protein |
denotes |
TNF-α |
| T3768 |
5166-5170 |
Protein |
denotes |
IL-1 |
| T3771 |
5231-5235 |
Protein |
denotes |
CD4+ |
| T3772 |
5308-5312 |
Protein |
denotes |
CD28 |
| T3784 |
5424-5431 |
Binding |
denotes |
linkage |
| T3783 |
5424-5431 |
Binding |
denotes |
linkage |
| T3782 |
5424-5431 |
Binding |
denotes |
linkage |
| T3773 |
5439-5460 |
Protein |
denotes |
MHC class II antigens |
| T3774 |
5461-5464 |
Protein |
denotes |
HLA |
| T3775 |
5465-5469 |
Protein |
denotes |
DRB1 |
| T3776 |
5479-5482 |
Protein |
denotes |
HLA |
| T3777 |
5483-5487 |
Protein |
denotes |
DRB1 |
| T3788 |
5565-5575 |
Gene_expression |
denotes |
expression |
| T3787 |
5565-5575 |
Gene_expression |
denotes |
expression |
| T3786 |
5565-5575 |
Gene_expression |
denotes |
expression |
| T3785 |
5565-5575 |
Gene_expression |
denotes |
expression |
| T3778 |
5579-5601 |
Protein |
denotes |
MHC class II molecules |
| T3779 |
5611-5623 |
Protein |
denotes |
CD28 ligands |
| T3780 |
5625-5629 |
Protein |
denotes |
CD80 |
| T3781 |
5634-5638 |
Protein |
denotes |
CD86 |
| T3789 |
5706-5709 |
Protein |
denotes |
CD4 |
| T3790 |
5887-5891 |
Protein |
denotes |
CD69 |
| T3791 |
5896-5900 |
Protein |
denotes |
CD11 |
| T3795 |
5917-5924 |
Localization |
denotes |
release |
| T3794 |
5917-5924 |
Localization |
denotes |
release |
| T3792 |
5966-5982 |
Protein |
denotes |
interferon gamma |
| T3793 |
5984-5987 |
Protein |
denotes |
IFN |
| T3796 |
6023-6027 |
Protein |
denotes |
CD4+ |
| T3798 |
6059-6069 |
Gene_expression |
denotes |
production |
| T3797 |
6096-6113 |
Protein |
denotes |
rheumatoid factor |
| T3799 |
6370-6373 |
Protein |
denotes |
IgG |
| T3807 |
6385-6390 |
Negative_regulation |
denotes |
block |
| T3806 |
6385-6390 |
Negative_regulation |
denotes |
block |
| T3803 |
6395-6405 |
Binding |
denotes |
engagement |
| T3800 |
6409-6413 |
Protein |
denotes |
CD28 |
| T3805 |
6428-6435 |
Binding |
denotes |
binding |
| T3804 |
6428-6435 |
Binding |
denotes |
binding |
| T3801 |
6439-6443 |
Protein |
denotes |
CD80 |
| T3802 |
6448-6452 |
Protein |
denotes |
CD86 |
| T3808 |
6477-6482 |
Protein |
denotes |
IL-10 |
| T3809 |
6566-6570 |
Protein |
denotes |
CD28 |
| T3810 |
6708-6712 |
Protein |
denotes |
CD4+ |
| T3832 |
6757-6769 |
Positive_regulation |
denotes |
investigated |
| T3831 |
6757-6769 |
Positive_regulation |
denotes |
investigated |
| T3830 |
6757-6769 |
Positive_regulation |
denotes |
investigated |
| T3829 |
6757-6769 |
Positive_regulation |
denotes |
investigated |
| T3820 |
6774-6784 |
Gene_expression |
denotes |
production |
| T3811 |
6788-6793 |
Protein |
denotes |
IFN-γ |
| T3834 |
6794-6799 |
Positive_regulation |
denotes |
after |
| T3833 |
6794-6799 |
Positive_regulation |
denotes |
after |
| T3836 |
6794-6799 |
Positive_regulation |
denotes |
after |
| T3835 |
6794-6799 |
Positive_regulation |
denotes |
after |
| T3812 |
6800-6803 |
Protein |
denotes |
CD3 |
| T3813 |
6808-6812 |
Protein |
denotes |
CD28 |
| T3822 |
6813-6826 |
Positive_regulation |
denotes |
costimulation |
| T3821 |
6813-6826 |
Positive_regulation |
denotes |
costimulation |
| T3814 |
6846-6851 |
Protein |
denotes |
IL-10 |
| T3824 |
6857-6866 |
Positive_regulation |
denotes |
induction |
| T3823 |
6857-6866 |
Positive_regulation |
denotes |
induction |
| T3838 |
6857-6866 |
Positive_regulation |
denotes |
induction |
| T3837 |
6857-6866 |
Positive_regulation |
denotes |
induction |
| T3815 |
6870-6875 |
Protein |
denotes |
STAT1 |
| T3816 |
6880-6885 |
Protein |
denotes |
STAT3 |
| T3826 |
6886-6901 |
Phosphorylation |
denotes |
phosphorylation |
| T3825 |
6886-6901 |
Phosphorylation |
denotes |
phosphorylation |
| T3817 |
6905-6910 |
Protein |
denotes |
IL-10 |
| T3828 |
6920-6930 |
Gene_expression |
denotes |
expression |
| T3827 |
6920-6930 |
Gene_expression |
denotes |
expression |
| T3818 |
6934-6939 |
Protein |
denotes |
SOCS1 |
| T3819 |
6944-6954 |
Protein |
denotes |
SOCS3 mRNA |
| T6868 |
7575-7599 |
Protein |
denotes |
serum C-reactive protein |
| T6869 |
7601-7604 |
Protein |
denotes |
CRP |
| T6870 |
7635-7638 |
Protein |
denotes |
IgM |
| T6872 |
7808-7816 |
Positive_regulation |
denotes |
elevated |
| T6871 |
7817-7826 |
Protein |
denotes |
serum CRP |
| T7494 |
8217-8221 |
Protein |
denotes |
CD4+ |
| T7495 |
8403-8407 |
Protein |
denotes |
CD4+ |
| T7496 |
8473-8476 |
Protein |
denotes |
CD4 |
| T7497 |
8587-8591 |
Protein |
denotes |
CD4+ |
| T7498 |
8721-8732 |
Protein |
denotes |
collagenase |
| T7499 |
8737-8742 |
Protein |
denotes |
DNase |
| T7500 |
9210-9214 |
Protein |
denotes |
CD4+ |
| T8076 |
9293-9297 |
Protein |
denotes |
CD4+ |
| T8077 |
9309-9312 |
Protein |
denotes |
CD4 |
| T8078 |
9523-9543 |
Protein |
denotes |
1 μg/ml anti-CD3 mAb |
| T8079 |
9620-9624 |
Protein |
denotes |
CD28 |
| T8080 |
9948-9952 |
Protein |
denotes |
IL-6 |
| T8081 |
9981-9986 |
Protein |
denotes |
IL-10 |
| T8082 |
9988-9991 |
Protein |
denotes |
CD4 |
| T8083 |
10191-10203 |
Protein |
denotes |
anti-CD3 mAb |
| T8084 |
10208-10221 |
Protein |
denotes |
anti-CD28 mAb |
| T8085 |
10306-10311 |
Protein |
denotes |
IFN-γ |
| T8712 |
10358-10365 |
Protein |
denotes |
IL-10R1 |
| T8713 |
10366-10376 |
Gene_expression |
denotes |
expression |
| T8714 |
10501-10517 |
Protein |
denotes |
anti-IL-10R1 mAb |
| T8715 |
10519-10523 |
Protein |
denotes |
IgG1 |
| T8716 |
10670-10674 |
Protein |
denotes |
IgG1 |
| T9089 |
10983-10988 |
Protein |
denotes |
IFN-γ |
| T9090 |
10993-10997 |
Protein |
denotes |
IL-2 |
| T9091 |
11016-11021 |
Protein |
denotes |
IFN-γ |
| T9092 |
11026-11030 |
Protein |
denotes |
IL-2 |
| T9093 |
11058-11062 |
Protein |
denotes |
CD4+ |
| T9094 |
11193-11230 |
Protein |
denotes |
mAb and recombinant cytokine proteins |
| T9095 |
11327-11332 |
Protein |
denotes |
IFN-γ |
| T9096 |
11337-11341 |
Protein |
denotes |
IL-2 |
| T9777 |
11637-11658 |
Protein |
denotes |
reverse transcriptase |
| T9778 |
11899-11917 |
Protein |
denotes |
Taq DNA polymerase |
| T9779 |
12234-12241 |
Protein |
denotes |
β-actin |
| T9780 |
12301-12306 |
Protein |
denotes |
SOCS1 |
| T9781 |
12370-12375 |
Protein |
denotes |
SOCS3 |
| T9782 |
12523-12528 |
Protein |
denotes |
SOCS1 |
| T9783 |
12533-12538 |
Protein |
denotes |
SOCS3 |
| T9786 |
12539-12549 |
Gene_expression |
denotes |
expression |
| T9785 |
12539-12549 |
Gene_expression |
denotes |
expression |
| T9784 |
12593-12600 |
Protein |
denotes |
β-actin |
| T9787 |
12601-12611 |
Gene_expression |
denotes |
expression |
| T9788 |
12666-12673 |
Protein |
denotes |
β-actin |
| T9789 |
12743-12748 |
Protein |
denotes |
SOCS1 |
| T9790 |
12818-12823 |
Protein |
denotes |
SOCS3 |
| T11026 |
12903-12907 |
Protein |
denotes |
CD4+ |
| T11027 |
12978-12983 |
Protein |
denotes |
IL-10 |
| T11028 |
12988-12992 |
Protein |
denotes |
IL-6 |
| T11039 |
13077-13083 |
Positive_regulation |
denotes |
effect |
| T11029 |
13087-13097 |
Protein |
denotes |
serum IL-6 |
| T11030 |
13101-13105 |
Protein |
denotes |
STAT |
| T11035 |
13106-13121 |
Phosphorylation |
denotes |
phosphorylation |
| T11031 |
13130-13134 |
Protein |
denotes |
CD4+ |
| T11038 |
13227-13239 |
Negative_regulation |
denotes |
neutralizing |
| T11037 |
13227-13239 |
Negative_regulation |
denotes |
neutralizing |
| T11036 |
13227-13239 |
Negative_regulation |
denotes |
neutralizing |
| T11032 |
13240-13274 |
Protein |
denotes |
goat anti-IL-6 polyclonal antibody |
| T11033 |
13276-13279 |
Protein |
denotes |
IgG |
| T11034 |
13325-13328 |
Protein |
denotes |
IgG |
| T11042 |
13761-13769 |
Entity |
denotes |
Tyrosine |
| T11044 |
13770-13785 |
Phosphorylation |
denotes |
phosphorylation |
| T11043 |
13770-13785 |
Phosphorylation |
denotes |
phosphorylation |
| T11040 |
13789-13794 |
Protein |
denotes |
STAT1 |
| T11041 |
13799-13804 |
Protein |
denotes |
STAT3 |
| T11045 |
14032-14082 |
Protein |
denotes |
anti-phosphorylated tyrosine 701 of STAT1 antibody |
| T11046 |
14084-14103 |
Protein |
denotes |
anti-STAT3 antibody |
| T11047 |
14109-14159 |
Protein |
denotes |
anti-phosphorylated tyrosine 705 of STAT3 antibody |
| T11049 |
14261-14268 |
Binding |
denotes |
binding |
| T11048 |
14285-14343 |
Protein |
denotes |
horseradish peroxidase-conjugated anti-rabbit IgG antibody |
| T11050 |
14549-14553 |
Protein |
denotes |
STAT |
| T11053 |
14554-14569 |
Phosphorylation |
denotes |
phosphorylation |
| T11052 |
14554-14569 |
Phosphorylation |
denotes |
phosphorylation |
| T11051 |
14608-14620 |
Protein |
denotes |
STAT protein |
| T11054 |
14622-14627 |
Protein |
denotes |
IFN-γ |
| T11057 |
14674-14681 |
Positive_regulation |
denotes |
control |
| T11055 |
14686-14691 |
Protein |
denotes |
STAT1 |
| T11056 |
14692-14708 |
Phosphorylation |
denotes |
phosophorylation |
| T13009 |
14998-15008 |
Gene_expression |
denotes |
Resistance |
| T13006 |
15012-15017 |
Protein |
denotes |
IL-10 |
| T13011 |
15018-15028 |
Negative_regulation |
denotes |
inhibition |
| T13007 |
15032-15037 |
Protein |
denotes |
IFN-γ |
| T13010 |
15038-15048 |
Gene_expression |
denotes |
production |
| T13008 |
15052-15067 |
Protein |
denotes |
RA CD4+ T cells |
| T13012 |
15072-15076 |
Protein |
denotes |
CD28 |
| T13019 |
15218-15228 |
Negative_regulation |
denotes |
inhibiting |
| T13018 |
15218-15228 |
Negative_regulation |
denotes |
inhibiting |
| T13013 |
15229-15233 |
Protein |
denotes |
CD28 |
| T13015 |
15234-15242 |
Entity |
denotes |
tyrosine |
| T13016 |
15243-15258 |
Phosphorylation |
denotes |
phosphorylation |
| T13017 |
15263-15270 |
Binding |
denotes |
binding |
| T13014 |
15274-15303 |
Protein |
denotes |
phosphatidylinositol 3-kinase |
| T13020 |
15344-15350 |
Protein |
denotes |
RA CD4 |
| T13021 |
15363-15368 |
Protein |
denotes |
IL-10 |
| T13022 |
15382-15385 |
Protein |
denotes |
CD4 |
| T13023 |
15493-15510 |
Protein |
denotes |
anti-CD3 antibody |
| T13024 |
15515-15533 |
Protein |
denotes |
anti-CD28 antibody |
| T13025 |
15576-15581 |
Protein |
denotes |
IL-10 |
| T13026 |
15600-15605 |
Protein |
denotes |
IFN-γ |
| T13027 |
15606-15616 |
Gene_expression |
denotes |
production |
| T13028 |
15652-15655 |
Protein |
denotes |
Fig |
| T13029 |
15660-15665 |
Protein |
denotes |
IFN-γ |
| T13031 |
15666-15676 |
Gene_expression |
denotes |
production |
| T13030 |
15697-15701 |
Protein |
denotes |
CD4+ |
| T13032 |
15721-15730 |
Negative_regulation |
denotes |
inhibited |
| T13033 |
15783-15789 |
Protein |
denotes |
RA CD4 |
| T13036 |
15812-15819 |
Gene_expression |
denotes |
produce |
| T13034 |
15843-15848 |
Protein |
denotes |
IFN-γ |
| T13035 |
15930-15935 |
Protein |
denotes |
IL-10 |
| T13037 |
15997-16002 |
Protein |
denotes |
IFN-γ |
| T13043 |
16003-16013 |
Gene_expression |
denotes |
production |
| T13038 |
16017-16021 |
Protein |
denotes |
CD4+ |
| T13039 |
16036-16039 |
Protein |
denotes |
CD3 |
| T13040 |
16044-16048 |
Protein |
denotes |
CD28 |
| T13041 |
16162-16165 |
Protein |
denotes |
CRP |
| T13042 |
16219-16222 |
Protein |
denotes |
CRP |
| T13044 |
16325-16330 |
Protein |
denotes |
IFN-γ |
| T13049 |
16331-16341 |
Gene_expression |
denotes |
production |
| T13048 |
16331-16341 |
Gene_expression |
denotes |
production |
| T13045 |
16382-16389 |
Protein |
denotes |
Fig. 2a |
| T13046 |
16421-16426 |
Protein |
denotes |
IL-10 |
| T13047 |
16430-16435 |
Protein |
denotes |
IFN-γ |
| T13051 |
16436-16446 |
Gene_expression |
denotes |
production |
| T13050 |
16436-16446 |
Gene_expression |
denotes |
production |
| T13052 |
16681-16685 |
Protein |
denotes |
CD4+ |
| T13053 |
16744-16749 |
Protein |
denotes |
IFN-γ |
| T13054 |
16799-16803 |
Protein |
denotes |
CD4+ |
| T13055 |
16813-16820 |
Protein |
denotes |
Fig. 2a |
| T13056 |
16867-16871 |
Protein |
denotes |
CD4+ |
| T13057 |
16886-16889 |
Protein |
denotes |
CD3 |
| T13058 |
16894-16898 |
Protein |
denotes |
CD28 |
| T13059 |
16932-16937 |
Protein |
denotes |
IL-10 |
| T13060 |
16996-17000 |
Protein |
denotes |
IL-2 |
| T13061 |
17001-17011 |
Gene_expression |
denotes |
production |
| T13062 |
17020-17028 |
Regulation |
denotes |
affected |
| T13063 |
17226-17229 |
Protein |
denotes |
CD4 |
| T13064 |
17297-17302 |
Protein |
denotes |
IL-10 |
| T14823 |
17329-17338 |
Positive_regulation |
denotes |
Increased |
| T14822 |
17339-17349 |
Gene_expression |
denotes |
expression |
| T14821 |
17377-17392 |
Protein |
denotes |
RA CD4+ T cells |
| T14824 |
17428-17433 |
Protein |
denotes |
IL-10 |
| T14825 |
17552-17559 |
Protein |
denotes |
IL-10R1 |
| T14826 |
17560-17570 |
Gene_expression |
denotes |
expression |
| T14827 |
17667-17672 |
Protein |
denotes |
IL-10 |
| T14831 |
17673-17683 |
Negative_regulation |
denotes |
inhibition |
| T14828 |
17687-17693 |
Protein |
denotes |
RA CD4 |
| T14832 |
17760-17770 |
Gene_expression |
denotes |
expression |
| T14829 |
17774-17781 |
Protein |
denotes |
IL-10R1 |
| T14830 |
17785-17791 |
Protein |
denotes |
PB CD4 |
| T14833 |
17907-17910 |
Protein |
denotes |
Fig |
| T14834 |
17936-17943 |
Protein |
denotes |
IL-10R1 |
| T14836 |
17944-17954 |
Gene_expression |
denotes |
expression |
| T14835 |
17958-17962 |
Protein |
denotes |
CD4+ |
| T14837 |
17989-17998 |
Positive_regulation |
denotes |
increased |
| T14838 |
18125-18130 |
Protein |
denotes |
IL-10 |
| T14839 |
18150-18154 |
Protein |
denotes |
CD4+ |
| T16053 |
18178-18187 |
Negative_regulation |
denotes |
Defective |
| T16052 |
18178-18187 |
Negative_regulation |
denotes |
Defective |
| T16047 |
18188-18193 |
Protein |
denotes |
IL-10 |
| T16055 |
18194-18202 |
Positive_regulation |
denotes |
mediated |
| T16054 |
18194-18202 |
Positive_regulation |
denotes |
mediated |
| T16048 |
18203-18208 |
Protein |
denotes |
STAT3 |
| T16051 |
18209-18224 |
Phosphorylation |
denotes |
phosphorylation |
| T16050 |
18209-18224 |
Phosphorylation |
denotes |
phosphorylation |
| T16049 |
18228-18243 |
Protein |
denotes |
RA CD4+ T cells |
| T16060 |
18248-18259 |
Binding |
denotes |
interaction |
| T16056 |
18263-18269 |
Protein |
denotes |
IL-10R |
| T16057 |
18275-18280 |
Protein |
denotes |
IL-10 |
| T16061 |
18289-18297 |
Entity |
denotes |
tyrosine |
| T16058 |
18365-18370 |
Protein |
denotes |
STAT1 |
| T16059 |
18375-18380 |
Protein |
denotes |
STAT3 |
| T16062 |
18406-18411 |
Protein |
denotes |
STAT3 |
| T16066 |
18412-18421 |
Negative_regulation |
denotes |
deficient |
| T16063 |
18445-18450 |
Protein |
denotes |
STAT3 |
| T16064 |
18476-18481 |
Protein |
denotes |
IL-10 |
| T16065 |
18611-18616 |
Protein |
denotes |
STAT3 |
| T16068 |
18617-18631 |
Positive_regulation |
denotes |
overexpression |
| T16067 |
18617-18631 |
Gene_expression |
denotes |
overexpression |
| T16078 |
18642-18651 |
Positive_regulation |
denotes |
induction |
| T16077 |
18642-18651 |
Positive_regulation |
denotes |
induction |
| T16074 |
18642-18651 |
Positive_regulation |
denotes |
induction |
| T16073 |
18642-18651 |
Positive_regulation |
denotes |
induction |
| T16069 |
18655-18660 |
Protein |
denotes |
STAT1 |
| T16070 |
18665-18670 |
Protein |
denotes |
STAT3 |
| T16076 |
18671-18686 |
Phosphorylation |
denotes |
phosphorylation |
| T16075 |
18671-18686 |
Phosphorylation |
denotes |
phosphorylation |
| T16071 |
18690-18695 |
Protein |
denotes |
IL-10 |
| T16072 |
18699-18705 |
Protein |
denotes |
PB CD4 |
| T16079 |
18802-18807 |
Protein |
denotes |
STAT3 |
| T16083 |
18808-18823 |
Phosphorylation |
denotes |
phosphorylation |
| T16086 |
18845-18852 |
Positive_regulation |
denotes |
induced |
| T16084 |
18845-18852 |
Positive_regulation |
denotes |
induced |
| T16080 |
18859-18864 |
Protein |
denotes |
IL-10 |
| T16085 |
18865-18875 |
Positive_regulation |
denotes |
activation |
| T16081 |
18897-18901 |
Protein |
denotes |
CD4+ |
| T16082 |
18911-18921 |
Protein |
denotes |
Fig. 4a,4b |
| T16087 |
18937-18942 |
Protein |
denotes |
STAT3 |
| T16090 |
18947-18961 |
Phosphorylation |
denotes |
phosphorylated |
| T16088 |
18982-18988 |
Protein |
denotes |
PB CD4 |
| T16089 |
19022-19027 |
Protein |
denotes |
STAT3 |
| T16091 |
19028-19043 |
Phosphorylation |
denotes |
phosphorylation |
| T16092 |
19048-19058 |
Positive_regulation |
denotes |
detectable |
| T16093 |
19078-19083 |
Protein |
denotes |
STAT3 |
| T16094 |
19084-19099 |
Phosphorylation |
denotes |
phosphorylation |
| T16095 |
19104-19113 |
Positive_regulation |
denotes |
augmented |
| T16096 |
19179-19184 |
Protein |
denotes |
STAT3 |
| T16102 |
19185-19200 |
Phosphorylation |
denotes |
phosphorylation |
| T16106 |
19205-19214 |
Negative_regulation |
denotes |
defective |
| T16097 |
19215-19220 |
Protein |
denotes |
IL-10 |
| T16107 |
19221-19228 |
Positive_regulation |
denotes |
induced |
| T16098 |
19229-19234 |
Protein |
denotes |
STAT3 |
| T16103 |
19235-19250 |
Phosphorylation |
denotes |
phosphorylation |
| T16105 |
19256-19261 |
Positive_regulation |
denotes |
found |
| T16104 |
19256-19261 |
Positive_regulation |
denotes |
found |
| T16099 |
19265-19270 |
Protein |
denotes |
RA ST |
| T16100 |
19271-19274 |
Protein |
denotes |
CD4 |
| T16101 |
19285-19292 |
Protein |
denotes |
Fig. 4c |
| T16114 |
19314-19327 |
Positive_regulation |
denotes |
IL-10-induced |
| T16108 |
19328-19333 |
Protein |
denotes |
STAT1 |
| T16112 |
19334-19349 |
Phosphorylation |
denotes |
phosphorylation |
| T16113 |
19358-19366 |
Positive_regulation |
denotes |
detected |
| T16109 |
19377-19383 |
Protein |
denotes |
RA CD4 |
| T16110 |
19403-19407 |
Protein |
denotes |
CD4+ |
| T16111 |
19417-19424 |
Protein |
denotes |
Fig. 4a |
| T16115 |
19455-19460 |
Protein |
denotes |
STAT3 |
| T16122 |
19474-19489 |
Positive_regulation |
denotes |
IL-10-activated |
| T16121 |
19474-19489 |
Positive_regulation |
denotes |
IL-10-activated |
| T16116 |
19490-19494 |
Protein |
denotes |
STAT |
| T16117 |
19498-19502 |
Protein |
denotes |
CD4+ |
| T16118 |
19516-19521 |
Protein |
denotes |
IL-10 |
| T16119 |
19530-19535 |
Protein |
denotes |
STAT3 |
| T16120 |
19609-19614 |
Protein |
denotes |
STAT3 |
| T16123 |
19615-19630 |
Phosphorylation |
denotes |
phosphorylation |
| T18300 |
19633-19637 |
Protein |
denotes |
IL-6 |
| T18306 |
19638-19646 |
Positive_regulation |
denotes |
mediated |
| T18301 |
19647-19652 |
Protein |
denotes |
STAT3 |
| T18304 |
19653-19668 |
Phosphorylation |
denotes |
phosphorylation |
| T18307 |
19673-19683 |
Negative_regulation |
denotes |
inhibition |
| T18302 |
19687-19692 |
Protein |
denotes |
IL-10 |
| T18305 |
19693-19699 |
Regulation |
denotes |
effect |
| T18303 |
19710-19714 |
Protein |
denotes |
CD4+ |
| T18308 |
19723-19728 |
Protein |
denotes |
STAT3 |
| T18313 |
19732-19741 |
Positive_regulation |
denotes |
activated |
| T18309 |
19823-19828 |
Protein |
denotes |
IL-11 |
| T18310 |
19862-19874 |
Protein |
denotes |
oncostatin M |
| T18311 |
20008-20012 |
Protein |
denotes |
IL-6 |
| T18315 |
20059-20066 |
Positive_regulation |
denotes |
induces |
| T18314 |
20080-20090 |
Positive_regulation |
denotes |
activation |
| T18312 |
20094-20099 |
Protein |
denotes |
STAT3 |
| T18316 |
20133-20137 |
Protein |
denotes |
IL-6 |
| T18317 |
20268-20272 |
Protein |
denotes |
CD4+ |
| T18321 |
20289-20303 |
Positive_regulation |
denotes |
concentrations |
| T18318 |
20307-20311 |
Protein |
denotes |
IL-6 |
| T18324 |
20341-20352 |
Positive_regulation |
denotes |
responsible |
| T18319 |
20373-20378 |
Protein |
denotes |
STAT3 |
| T18322 |
20379-20389 |
Positive_regulation |
denotes |
activation |
| T18320 |
20408-20413 |
Protein |
denotes |
IL-10 |
| T18323 |
20414-20424 |
Negative_regulation |
denotes |
inhibition |
| T18325 |
20444-20449 |
Protein |
denotes |
STAT1 |
| T18326 |
20454-20459 |
Protein |
denotes |
STAT3 |
| T18330 |
20460-20475 |
Phosphorylation |
denotes |
phosphorylation |
| T18329 |
20460-20475 |
Phosphorylation |
denotes |
phosphorylation |
| T18334 |
20480-20489 |
Positive_regulation |
denotes |
activated |
| T18333 |
20480-20489 |
Positive_regulation |
denotes |
activated |
| T18332 |
20480-20489 |
Positive_regulation |
denotes |
activated |
| T18331 |
20480-20489 |
Positive_regulation |
denotes |
activated |
| T18327 |
20493-20497 |
Protein |
denotes |
IL-6 |
| T18328 |
20508-20512 |
Protein |
denotes |
CD4+ |
| T18335 |
20591-20594 |
Protein |
denotes |
CD4 |
| T18338 |
20704-20716 |
Positive_regulation |
denotes |
neutralizing |
| T18336 |
20717-20755 |
Protein |
denotes |
anti-IL-6 antibody or control antibody |
| T18337 |
20761-20765 |
Protein |
denotes |
STAT |
| T18339 |
20766-20781 |
Phosphorylation |
denotes |
phosphorylation |
| T18352 |
20842-20848 |
Positive_regulation |
denotes |
induce |
| T18351 |
20842-20848 |
Positive_regulation |
denotes |
induce |
| T18345 |
20849-20857 |
Entity |
denotes |
tyrosine |
| T18347 |
20858-20873 |
Phosphorylation |
denotes |
phosphorylation |
| T18346 |
20858-20873 |
Phosphorylation |
denotes |
phosphorylation |
| T18340 |
20877-20882 |
Protein |
denotes |
STAT3 |
| T18341 |
20891-20896 |
Protein |
denotes |
STAT1 |
| T18342 |
20907-20912 |
Protein |
denotes |
STAT3 |
| T18348 |
20913-20923 |
Positive_regulation |
denotes |
activation |
| T18354 |
20935-20944 |
Negative_regulation |
denotes |
abolished |
| T18353 |
20935-20944 |
Negative_regulation |
denotes |
abolished |
| T18350 |
20948-20962 |
Negative_regulation |
denotes |
neutralization |
| T18349 |
20948-20962 |
Negative_regulation |
denotes |
neutralization |
| T18343 |
20966-20970 |
Protein |
denotes |
IL-6 |
| T18344 |
20981-20988 |
Protein |
denotes |
Fig. 5a |
| T18355 |
21019-21023 |
Protein |
denotes |
IL-6 |
| T18356 |
21031-21063 |
Protein |
denotes |
dominant STAT3-activating factor |
| T18368 |
21109-21113 |
Negative_regulation |
denotes |
lack |
| T18357 |
21117-21122 |
Protein |
denotes |
STAT1 |
| T18362 |
21123-21133 |
Positive_regulation |
denotes |
activation |
| T18363 |
21172-21186 |
Positive_regulation |
denotes |
concentrations |
| T18358 |
21190-21194 |
Protein |
denotes |
IL-6 |
| T18369 |
21202-21210 |
Positive_regulation |
denotes |
required |
| T18359 |
21215-21220 |
Protein |
denotes |
STAT1 |
| T18364 |
21221-21231 |
Positive_regulation |
denotes |
activation |
| T18360 |
21249-21254 |
Protein |
denotes |
STAT3 |
| T18365 |
21255-21265 |
Positive_regulation |
denotes |
activation |
| T18366 |
21275-21285 |
Negative_regulation |
denotes |
inhibitors |
| T18361 |
21289-21294 |
Protein |
denotes |
STAT1 |
| T18367 |
21312-21319 |
Positive_regulation |
denotes |
present |
| T18370 |
21358-21362 |
Protein |
denotes |
IL-6 |
| T18371 |
21392-21397 |
Protein |
denotes |
IL-10 |
| T18375 |
21401-21408 |
Negative_regulation |
denotes |
inhibit |
| T18372 |
21409-21414 |
Protein |
denotes |
IFN-γ |
| T18374 |
21415-21425 |
Gene_expression |
denotes |
production |
| T18373 |
21429-21433 |
Protein |
denotes |
CD4+ |
| T18376 |
21514-21518 |
Protein |
denotes |
CD4+ |
| T18377 |
21546-21549 |
Protein |
denotes |
CD3 |
| T18378 |
21554-21558 |
Protein |
denotes |
CD28 |
| T18379 |
21639-21644 |
Protein |
denotes |
IFN-γ |
| T18380 |
21645-21655 |
Gene_expression |
denotes |
production |
| T18387 |
21713-21720 |
Negative_regulation |
denotes |
reduced |
| T18381 |
21721-21726 |
Protein |
denotes |
IL-10 |
| T18386 |
21736-21746 |
Negative_regulation |
denotes |
inhibition |
| T18382 |
21750-21755 |
Protein |
denotes |
IFN-γ |
| T18385 |
21756-21766 |
Gene_expression |
denotes |
production |
| T18383 |
21817-21821 |
Protein |
denotes |
IL-6 |
| T18384 |
21862-21867 |
Protein |
denotes |
IL-10 |
| T18388 |
21936-21946 |
Protein |
denotes |
serum IL-6 |
| T18389 |
21988-21993 |
Protein |
denotes |
STAT3 |
| T18390 |
22052-22057 |
Protein |
denotes |
IL-10 |
| T18391 |
22061-22067 |
Protein |
denotes |
RA CD4 |
| T20559 |
22079-22083 |
Positive_regulation |
denotes |
High |
| T20558 |
22079-22083 |
Positive_regulation |
denotes |
High |
| T20557 |
22084-22094 |
Gene_expression |
denotes |
expression |
| T20556 |
22084-22094 |
Gene_expression |
denotes |
expression |
| T20554 |
22098-22108 |
Protein |
denotes |
SOCS1 mRNA |
| T20555 |
22112-22127 |
Protein |
denotes |
RA CD4+ T cells |
| T20560 |
22128-22132 |
Protein |
denotes |
IL-6 |
| T20565 |
22152-22162 |
Negative_regulation |
denotes |
inhibitors |
| T20564 |
22152-22162 |
Negative_regulation |
denotes |
inhibitors |
| T20561 |
22166-22170 |
Protein |
denotes |
JAKs |
| T20562 |
22172-22177 |
Protein |
denotes |
SOCS1 |
| T20563 |
22182-22196 |
Protein |
denotes |
SOCS3 proteins |
| T20566 |
22364-22369 |
Protein |
denotes |
SOCS3 |
| T20567 |
22418-22423 |
Protein |
denotes |
STAT3 |
| T20568 |
22446-22450 |
Protein |
denotes |
IL-6 |
| T20572 |
22477-22487 |
Regulation |
denotes |
regulating |
| T20571 |
22477-22487 |
Regulation |
denotes |
regulating |
| T20569 |
22512-22516 |
Protein |
denotes |
IL-6 |
| T20570 |
22521-22526 |
Protein |
denotes |
IL-10 |
| T20573 |
22551-22556 |
Protein |
denotes |
SOCS1 |
| T20579 |
22578-22585 |
Negative_regulation |
denotes |
inhibit |
| T20574 |
22586-22591 |
Protein |
denotes |
IL-10 |
| T20575 |
22601-22606 |
Protein |
denotes |
STAT3 |
| T20576 |
22653-22658 |
Protein |
denotes |
IFN-γ |
| T20578 |
22659-22667 |
Positive_regulation |
denotes |
mediated |
| T20577 |
22668-22673 |
Protein |
denotes |
STAT1 |
| T20580 |
22749-22754 |
Protein |
denotes |
IL-10 |
| T20589 |
22755-22762 |
Positive_regulation |
denotes |
induced |
| T20581 |
22763-22768 |
Protein |
denotes |
STAT3 |
| T20586 |
22769-22779 |
Positive_regulation |
denotes |
activation |
| T20582 |
22783-22789 |
Protein |
denotes |
RA CD4 |
| T20583 |
22814-22819 |
Protein |
denotes |
SOCS1 |
| T20584 |
22824-22834 |
Protein |
denotes |
SOCS3 mRNA |
| T20588 |
22835-22845 |
Gene_expression |
denotes |
expression |
| T20587 |
22835-22845 |
Gene_expression |
denotes |
expression |
| T20585 |
22849-22855 |
Protein |
denotes |
PB CD4 |
| T20590 |
22968-22975 |
Protein |
denotes |
RA CD4+ |
| T20595 |
23001-23007 |
Positive_regulation |
denotes |
levels |
| T20591 |
23011-23016 |
Protein |
denotes |
SOCS1 |
| T20596 |
23027-23033 |
Positive_regulation |
denotes |
levels |
| T20592 |
23037-23054 |
Protein |
denotes |
SOCS3 transcripts |
| T20597 |
23064-23071 |
Regulation |
denotes |
control |
| T20593 |
23072-23076 |
Protein |
denotes |
CD4+ |
| T20594 |
23086-23093 |
Protein |
denotes |
Fig. 6a |
| T20603 |
23109-23119 |
Gene_expression |
denotes |
expression |
| T20598 |
23123-23133 |
Protein |
denotes |
SOCS1 mRNA |
| T20599 |
23137-23143 |
Protein |
denotes |
RA CD4 |
| T20600 |
23198-23202 |
Protein |
denotes |
CD4+ |
| T20601 |
23234-23238 |
Protein |
denotes |
IL-6 |
| T20602 |
23240-23247 |
Protein |
denotes |
Fig. 6b |
| T20604 |
23314-23319 |
Protein |
denotes |
STAT3 |
| T20607 |
23320-23330 |
Positive_regulation |
denotes |
activation |
| T20608 |
23355-23358 |
Positive_regulation |
denotes |
due |
| T20609 |
23382-23391 |
Positive_regulation |
denotes |
abundance |
| T20605 |
23395-23400 |
Protein |
denotes |
SOCS1 |
| T20606 |
23404-23410 |
Protein |
denotes |
RA CD4 |
| T23904 |
23433-23437 |
Protein |
denotes |
CD4+ |
| T23905 |
23523-23527 |
Protein |
denotes |
CD4+ |
| T23906 |
23755-23759 |
Protein |
denotes |
CD4+ |
| T23907 |
23836-23840 |
Protein |
denotes |
CD28 |
| T23908 |
23887-23899 |
Protein |
denotes |
CD28 ligands |
| T23909 |
23906-23910 |
Protein |
denotes |
CD80 |
| T23910 |
23915-23919 |
Protein |
denotes |
CD86 |
| T23911 |
23935-23956 |
Protein |
denotes |
MHC class II antigens |
| T23915 |
23976-23985 |
Gene_expression |
denotes |
expressed |
| T23914 |
23976-23985 |
Gene_expression |
denotes |
expressed |
| T23913 |
23976-23985 |
Gene_expression |
denotes |
expressed |
| T23912 |
23976-23985 |
Gene_expression |
denotes |
expressed |
| T23916 |
24083-24098 |
Protein |
denotes |
CD28 engagement |
| T23917 |
24249-24252 |
Protein |
denotes |
IgG |
| T23918 |
24417-24422 |
Protein |
denotes |
IL-10 |
| T23922 |
24423-24431 |
Negative_regulation |
denotes |
inhibits |
| T23920 |
24436-24444 |
Entity |
denotes |
tyrosine |
| T23921 |
24445-24460 |
Phosphorylation |
denotes |
phosphorylation |
| T23919 |
24468-24481 |
Protein |
denotes |
CD28 molecule |
| T23923 |
24633-24636 |
Protein |
denotes |
CD4 |
| T23924 |
24695-24700 |
Protein |
denotes |
IL-10 |
| T23930 |
24714-24721 |
Gene_expression |
denotes |
produce |
| T23929 |
24714-24721 |
Gene_expression |
denotes |
produce |
| T23925 |
24739-24744 |
Protein |
denotes |
IFN-γ |
| T23926 |
24751-24754 |
Protein |
denotes |
CD3 |
| T23927 |
24759-24763 |
Protein |
denotes |
CD28 |
| T23928 |
24790-24794 |
Protein |
denotes |
CD4+ |
| T23945 |
24812-24822 |
Positive_regulation |
denotes |
high-level |
| T23931 |
24823-24830 |
Protein |
denotes |
IL-10R1 |
| T23938 |
24831-24841 |
Gene_expression |
denotes |
expression |
| T23932 |
24859-24864 |
Protein |
denotes |
STAT3 |
| T23939 |
24865-24875 |
Positive_regulation |
denotes |
activation |
| T23940 |
24891-24899 |
Entity |
denotes |
tyrosine |
| T23941 |
24900-24915 |
Phosphorylation |
denotes |
phosphorylation |
| T23933 |
24919-24924 |
Protein |
denotes |
STAT3 |
| T23942 |
24928-24938 |
Negative_regulation |
denotes |
suppressed |
| T23934 |
24942-24948 |
Protein |
denotes |
RA CD4 |
| T23935 |
24981-24984 |
Protein |
denotes |
CD4 |
| T23936 |
25001-25006 |
Protein |
denotes |
STAT3 |
| T23943 |
25007-25022 |
Phosphorylation |
denotes |
phosphorylation |
| T23944 |
25043-25052 |
Positive_regulation |
denotes |
inducible |
| T23937 |
25056-25061 |
Protein |
denotes |
IL-10 |
| T23956 |
25091-25098 |
Positive_regulation |
denotes |
induces |
| T23955 |
25091-25098 |
Positive_regulation |
denotes |
induces |
| T23946 |
25099-25104 |
Protein |
denotes |
STAT3 |
| T23947 |
25113-25118 |
Protein |
denotes |
STAT1 |
| T23953 |
25119-25134 |
Phosphorylation |
denotes |
phosphorylation |
| T23952 |
25119-25134 |
Phosphorylation |
denotes |
phosphorylation |
| T23948 |
25145-25149 |
Protein |
denotes |
CD4+ |
| T23949 |
25173-25177 |
Protein |
denotes |
IL-6 |
| T23959 |
25178-25185 |
Positive_regulation |
denotes |
induces |
| T23958 |
25190-25200 |
Positive_regulation |
denotes |
resistance |
| T23950 |
25204-25209 |
Protein |
denotes |
IL-10 |
| T23957 |
25210-25220 |
Negative_regulation |
denotes |
inhibition |
| T23951 |
25224-25229 |
Protein |
denotes |
IFN-γ |
| T23954 |
25230-25240 |
Gene_expression |
denotes |
production |
| T23960 |
25245-25249 |
Protein |
denotes |
CD4+ |
| T23964 |
25273-25279 |
Positive_regulation |
denotes |
levels |
| T23961 |
25283-25288 |
Protein |
denotes |
SOCS1 |
| T23965 |
25307-25313 |
Positive_regulation |
denotes |
levels |
| T23962 |
25317-25334 |
Protein |
denotes |
SOCS3 transcripts |
| T23963 |
25361-25365 |
Protein |
denotes |
CD4+ |
| T23966 |
25404-25408 |
Protein |
denotes |
CD4+ |
| T23967 |
25572-25577 |
Protein |
denotes |
IL-10 |
| T23968 |
25588-25593 |
Protein |
denotes |
STAT3 |
| T23969 |
25636-25641 |
Protein |
denotes |
STAT3 |
| T23971 |
25642-25657 |
Phosphorylation |
denotes |
phosphorylation |
| T23970 |
25662-25667 |
Protein |
denotes |
SOCS1 |
| T23973 |
25668-25677 |
Positive_regulation |
denotes |
induction |
| T23972 |
25668-25677 |
Positive_regulation |
denotes |
induction |
| T23974 |
25679-25684 |
Protein |
denotes |
IL-10 |
| T23975 |
25708-25711 |
Protein |
denotes |
CD4 |
| T23981 |
25974-25981 |
Gene_expression |
denotes |
express |
| T23980 |
25974-25981 |
Gene_expression |
denotes |
express |
| T23979 |
25974-25981 |
Gene_expression |
denotes |
express |
| T23976 |
26008-26012 |
Protein |
denotes |
CD80 |
| T23977 |
26017-26031 |
Protein |
denotes |
CD86 molecules |
| T23978 |
26037-26058 |
Protein |
denotes |
MHC class II antigens |
| T23982 |
26086-26091 |
Protein |
denotes |
IL-10 |
| T23986 |
26165-26175 |
Negative_regulation |
denotes |
inhibiting |
| T23983 |
26176-26180 |
Protein |
denotes |
CD28 |
| T23984 |
26181-26189 |
Entity |
denotes |
tyrosine |
| T23985 |
26190-26205 |
Phosphorylation |
denotes |
phosphorylation |
| T23987 |
26291-26295 |
Protein |
denotes |
CD4+ |
| T23988 |
26323-26328 |
Protein |
denotes |
IL-10 |
| T23995 |
26329-26339 |
Negative_regulation |
denotes |
inhibition |
| T23994 |
26329-26339 |
Negative_regulation |
denotes |
inhibition |
| T23989 |
26343-26347 |
Protein |
denotes |
CD28 |
| T23997 |
26348-26360 |
Positive_regulation |
denotes |
costimulated |
| T23996 |
26348-26360 |
Positive_regulation |
denotes |
costimulated |
| T23993 |
26361-26371 |
Gene_expression |
denotes |
production |
| T23992 |
26361-26371 |
Gene_expression |
denotes |
production |
| T23990 |
26380-26385 |
Protein |
denotes |
IFN-γ |
| T23991 |
26390-26394 |
Protein |
denotes |
IL-2 |
| T23998 |
26599-26604 |
Protein |
denotes |
IL-10 |
| T23999 |
26606-26614 |
Gene_expression |
denotes |
produced |
| T24000 |
26870-26880 |
Protein |
denotes |
p38 kinase |
| T24001 |
26902-26907 |
Protein |
denotes |
TNF-α |
| T24002 |
26912-26916 |
Protein |
denotes |
IL-1 |
| T24007 |
26918-26926 |
Negative_regulation |
denotes |
inhibits |
| T24003 |
26931-26935 |
Protein |
denotes |
Jak1 |
| T24004 |
26936-26941 |
Protein |
denotes |
STAT3 |
| T24005 |
26970-26975 |
Protein |
denotes |
IL-10 |
| T24006 |
26980-26984 |
Protein |
denotes |
IL-6 |
| T24008 |
27032-27037 |
Protein |
denotes |
IL-10 |
| T24011 |
27038-27046 |
Positive_regulation |
denotes |
mediated |
| T24009 |
27047-27052 |
Protein |
denotes |
STAT3 |
| T24010 |
27053-27063 |
Positive_regulation |
denotes |
activation |
| T24012 |
27129-27134 |
Protein |
denotes |
IL-10 |
| T24013 |
27263-27268 |
Protein |
denotes |
IL-10 |
| T24014 |
27277-27281 |
Protein |
denotes |
Jak1 |
| T24015 |
27311-27316 |
Protein |
denotes |
IFN-γ |
| T24016 |
27341-27357 |
Protein |
denotes |
protein kinase C |
| T24018 |
27386-27394 |
Binding |
denotes |
ligation |
| T24017 |
27402-27423 |
Protein |
denotes |
IgG Fc gamma receptor |
| T24019 |
27531-27536 |
Protein |
denotes |
IL-10 |
| T24020 |
27567-27588 |
Protein |
denotes |
intracellular IL-10R1 |
| T24021 |
27649-27654 |
Protein |
denotes |
TNF-α |
| T24022 |
27656-27660 |
Protein |
denotes |
IL-1 |
| T24023 |
27765-27771 |
Protein |
denotes |
RA CD4 |
| T24024 |
27784-27789 |
Protein |
denotes |
IL-10 |
| T24025 |
27823-27828 |
Protein |
denotes |
IL-10 |
| T24026 |
27839-27844 |
Protein |
denotes |
STAT3 |
| T24030 |
27845-27855 |
Positive_regulation |
denotes |
activation |
| T24028 |
27845-27855 |
Positive_regulation |
denotes |
activation |
| T24027 |
27870-27877 |
Protein |
denotes |
IL-10R1 |
| T24029 |
27878-27888 |
Gene_expression |
denotes |
expression |
| T24031 |
28094-28099 |
Protein |
denotes |
IL-10 |
| T24037 |
28100-28108 |
Positive_regulation |
denotes |
mediated |
| T24032 |
28109-28114 |
Protein |
denotes |
STAT3 |
| T24035 |
28115-28125 |
Positive_regulation |
denotes |
activation |
| T24033 |
28127-28132 |
Protein |
denotes |
STAT3 |
| T24036 |
28158-28172 |
Phosphorylation |
denotes |
phosphorylated |
| T24034 |
28232-28235 |
Protein |
denotes |
CD4 |
| T24038 |
28263-28268 |
Protein |
denotes |
STAT3 |
| T24043 |
28272-28281 |
Positive_regulation |
denotes |
activated |
| T24039 |
28321-28332 |
Protein |
denotes |
IL-6 family |
| T24040 |
28352-28356 |
Protein |
denotes |
IL-6 |
| T24041 |
28358-28363 |
Protein |
denotes |
IL-11 |
| T24042 |
28397-28409 |
Protein |
denotes |
oncostatin M |
| T24044 |
28675-28679 |
Protein |
denotes |
IL-6 |
| T24045 |
28694-28717 |
Protein |
denotes |
STAT3-activating factor |
| T24046 |
28790-28795 |
Protein |
denotes |
IL-10 |
| T24047 |
28821-28825 |
Protein |
denotes |
CD4+ |
| T24048 |
28868-28872 |
Protein |
denotes |
IL-6 |
| T24057 |
28910-28919 |
Positive_regulation |
denotes |
sustained |
| T24049 |
28920-28925 |
Protein |
denotes |
STAT3 |
| T24053 |
28926-28936 |
Positive_regulation |
denotes |
activation |
| T24050 |
28959-28964 |
Protein |
denotes |
IL-10 |
| T24054 |
28965-28975 |
Negative_regulation |
denotes |
inhibition |
| T24051 |
28985-28994 |
Protein |
denotes |
RA CD4+ T |
| T24058 |
29008-29015 |
Positive_regulation |
denotes |
induced |
| T24055 |
29008-29015 |
Positive_regulation |
denotes |
induced |
| T24056 |
29055-29069 |
Positive_regulation |
denotes |
concentrations |
| T24052 |
29073-29083 |
Protein |
denotes |
serum IL-6 |
| T24059 |
29119-29124 |
Protein |
denotes |
STAT3 |
| T24063 |
29158-29165 |
Positive_regulation |
denotes |
induced |
| T24060 |
29169-29173 |
Protein |
denotes |
CD4+ |
| T24061 |
29195-29200 |
Protein |
denotes |
IL-10 |
| T24065 |
29201-29210 |
Localization |
denotes |
secretion |
| T24064 |
29201-29210 |
Localization |
denotes |
secretion |
| T24062 |
29275-29281 |
Protein |
denotes |
RA CD4 |
| T24066 |
29360-29364 |
Protein |
denotes |
CD4+ |
| T24068 |
29414-29420 |
Negative_regulation |
denotes |
defect |
| T24067 |
29442-29447 |
Protein |
denotes |
STAT3 |
| T24069 |
29510-29514 |
Protein |
denotes |
CD4+ |
| T24070 |
29526-29531 |
Protein |
denotes |
IL-10 |
| T24072 |
29544-29553 |
Positive_regulation |
denotes |
augmented |
| T24071 |
29600-29604 |
Protein |
denotes |
IL-6 |
| T24073 |
29818-29823 |
Protein |
denotes |
IL-10 |
| T24074 |
29833-29838 |
Protein |
denotes |
IFN-γ |
| T24075 |
29853-29857 |
Protein |
denotes |
CD4+ |
| T24076 |
29899-29904 |
Protein |
denotes |
IL-1β |
| T24077 |
29909-29914 |
Protein |
denotes |
TNF-α |
| T24078 |
29986-29991 |
Protein |
denotes |
IFN-γ |
| T24079 |
29996-30001 |
Protein |
denotes |
IL-10 |
| T24083 |
30002-30010 |
Gene_expression |
denotes |
produced |
| T24082 |
30002-30010 |
Gene_expression |
denotes |
produced |
| T24080 |
30014-30018 |
Protein |
denotes |
CD4+ |
| T24081 |
30072-30077 |
Protein |
denotes |
IL-10 |
| T24085 |
30126-30133 |
Gene_expression |
denotes |
produce |
| T24084 |
30126-30133 |
Gene_expression |
denotes |
produce |
| T24086 |
30183-30188 |
Protein |
denotes |
IL-10 |
| T24093 |
30206-30215 |
Positive_regulation |
denotes |
stimulate |
| T24087 |
30216-30221 |
Protein |
denotes |
STAT3 |
| T24091 |
30222-30232 |
Positive_regulation |
denotes |
activation |
| T24088 |
30237-30242 |
Protein |
denotes |
IFN-γ |
| T24092 |
30247-30253 |
Positive_regulation |
denotes |
induce |
| T24089 |
30254-30267 |
Protein |
denotes |
SOCS1 protein |
| T24090 |
30296-30301 |
Protein |
denotes |
IL-10 |
| T24094 |
30350-30355 |
Protein |
denotes |
IL-10 |
| T24095 |
30509-30514 |
Protein |
denotes |
STAT3 |
| T24096 |
30515-30525 |
Positive_regulation |
denotes |
activation |
| T24097 |
30580-30585 |
Protein |
denotes |
STAT3 |
| T24098 |
30604-30613 |
Gene_expression |
denotes |
expressed |
| T24099 |
30673-30677 |
Protein |
denotes |
IL-6 |
| T24100 |
30691-30696 |
Protein |
denotes |
STAT3 |
| T24102 |
30820-30830 |
Gene_expression |
denotes |
expression |
| T24101 |
30838-30862 |
Protein |
denotes |
Fc gamma receptor type I |
| T24106 |
30926-30935 |
Positive_regulation |
denotes |
activated |
| T24103 |
30936-30941 |
Protein |
denotes |
STAT3 |
| T24104 |
30975-30979 |
Protein |
denotes |
IL-6 |
| T24105 |
31015-31020 |
Protein |
denotes |
STAT3 |
| T24107 |
31021-31031 |
Positive_regulation |
denotes |
activation |
| T24108 |
31141-31146 |
Protein |
denotes |
STAT3 |
| T24109 |
31287-31292 |
Protein |
denotes |
STAT3 |
| T24110 |
31417-31456 |
Protein |
denotes |
Src homology phosphatase-2 binding site |
| T24111 |
31460-31465 |
Protein |
denotes |
gp130 |
| T24112 |
31515-31544 |
Protein |
denotes |
IL-6 family cytokine receptor |
| T24114 |
31565-31572 |
Positive_regulation |
denotes |
mutated |
| T24113 |
31565-31572 |
Positive_regulation |
denotes |
mutated |
| T24115 |
31650-31654 |
Protein |
denotes |
CD4+ |
| T24116 |
31751-31756 |
Protein |
denotes |
gp130 |
| T24119 |
31757-31765 |
Positive_regulation |
denotes |
mediated |
| T24117 |
31766-31771 |
Protein |
denotes |
STAT3 |
| T24118 |
31772-31782 |
Positive_regulation |
denotes |
activation |
| T24120 |
31836-31839 |
Protein |
denotes |
JAK |
| T24121 |
31840-31844 |
Protein |
denotes |
STAT |
| T24122 |
31873-31884 |
Protein |
denotes |
SOCS family |
| T24123 |
31913-31917 |
Protein |
denotes |
CD4+ |
| T24127 |
31972-31978 |
Positive_regulation |
denotes |
levels |
| T24124 |
31982-31987 |
Protein |
denotes |
SOCS1 |
| T24128 |
31999-32005 |
Positive_regulation |
denotes |
levels |
| T24125 |
32009-32014 |
Protein |
denotes |
SOCS3 |
| T24126 |
32037-32041 |
Protein |
denotes |
CD4+ |
| T24129 |
32051-32056 |
Protein |
denotes |
SOCS1 |
| T24139 |
32057-32065 |
Negative_regulation |
denotes |
prevents |
| T24136 |
32066-32076 |
Positive_regulation |
denotes |
activation |
| T24130 |
32080-32083 |
Protein |
denotes |
JAK |
| T24137 |
32096-32103 |
Binding |
denotes |
binding |
| T24131 |
32107-32110 |
Protein |
denotes |
JAK |
| T24132 |
32116-32121 |
Protein |
denotes |
SOCS3 |
| T24133 |
32145-32148 |
Protein |
denotes |
JAK |
| T24138 |
32152-32159 |
Binding |
denotes |
binding |
| T24134 |
32167-32221 |
Protein |
denotes |
Src homology phosphatase-2-binding domain of receptors |
| T24135 |
32230-32235 |
Protein |
denotes |
gp130 |
| T24140 |
32242-32247 |
Protein |
denotes |
SOCS1 |
| T24141 |
32252-32257 |
Protein |
denotes |
SOCS3 |
| T24149 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24148 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24147 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24146 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24145 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24144 |
32262-32269 |
Positive_regulation |
denotes |
induced |
| T24142 |
32302-32306 |
Protein |
denotes |
IL-6 |
| T24143 |
32311-32316 |
Protein |
denotes |
IL-10 |
| T24156 |
32407-32414 |
Negative_regulation |
denotes |
lacking |
| T24155 |
32407-32414 |
Negative_regulation |
denotes |
lacking |
| T24150 |
32415-32420 |
Protein |
denotes |
SOCS3 |
| T24151 |
32424-32429 |
Protein |
denotes |
SOCS1 |
| T24152 |
32444-32449 |
Protein |
denotes |
SOCS3 |
| T24153 |
32477-32481 |
Protein |
denotes |
IL-6 |
| T24154 |
32503-32508 |
Protein |
denotes |
IL-10 |
| T24157 |
32543-32548 |
Protein |
denotes |
SOCS3 |
| T24161 |
32549-32558 |
Negative_regulation |
denotes |
deficient |
| T24158 |
32580-32585 |
Protein |
denotes |
SOCS3 |
| T24165 |
32586-32596 |
Negative_regulation |
denotes |
deficiency |
| T24162 |
32586-32596 |
Negative_regulation |
denotes |
deficiency |
| T24159 |
32606-32611 |
Protein |
denotes |
SOCS1 |
| T24163 |
32612-32622 |
Negative_regulation |
denotes |
deficiency |
| T24164 |
32645-32655 |
Positive_regulation |
denotes |
activation |
| T24160 |
32659-32664 |
Protein |
denotes |
STAT3 |
| T24166 |
32709-32714 |
Protein |
denotes |
SOCS3 |
| T24169 |
32715-32724 |
Negative_regulation |
denotes |
deficient |
| T24167 |
32756-32761 |
Protein |
denotes |
SOCS3 |
| T24168 |
32792-32796 |
Protein |
denotes |
IL-6 |
| T24170 |
32845-32850 |
Protein |
denotes |
SOCS3 |
| T24171 |
32943-32948 |
Protein |
denotes |
IL-10 |
| T24172 |
32987-32992 |
Protein |
denotes |
SOCS1 |
| T24173 |
33023-33028 |
Protein |
denotes |
IL-10 |
| T24186 |
33054-33063 |
Positive_regulation |
denotes |
Increased |
| T24174 |
33064-33069 |
Protein |
denotes |
SOCS1 |
| T24182 |
33070-33080 |
Gene_expression |
denotes |
expression |
| T24175 |
33084-33091 |
Protein |
denotes |
RA CD4+ |
| T24176 |
33169-33174 |
Protein |
denotes |
IL-10 |
| T24177 |
33182-33187 |
Protein |
denotes |
IL-10 |
| T24187 |
33188-33196 |
Positive_regulation |
denotes |
mediated |
| T24178 |
33197-33202 |
Protein |
denotes |
STAT3 |
| T24183 |
33203-33213 |
Positive_regulation |
denotes |
activation |
| T24188 |
33219-33228 |
Negative_regulation |
denotes |
defective |
| T24179 |
33229-33234 |
Protein |
denotes |
SOCS3 |
| T24184 |
33235-33245 |
Gene_expression |
denotes |
expression |
| T24180 |
33280-33285 |
Protein |
denotes |
STAT3 |
| T24185 |
33286-33296 |
Positive_regulation |
denotes |
activation |
| T24181 |
33312-33322 |
Protein |
denotes |
serum IL-6 |
| T24189 |
33352-33357 |
Protein |
denotes |
SOCS1 |
| T24195 |
33358-33367 |
Positive_regulation |
denotes |
induction |
| T24190 |
33406-33410 |
Protein |
denotes |
CD4+ |
| T24196 |
33422-33429 |
Gene_expression |
denotes |
produce |
| T24191 |
33430-33435 |
Protein |
denotes |
IFN-γ |
| T24192 |
33445-33449 |
Protein |
denotes |
CD4+ |
| T24197 |
33479-33486 |
Gene_expression |
denotes |
produce |
| T24193 |
33502-33507 |
Protein |
denotes |
IFN-γ |
| T24194 |
33546-33551 |
Protein |
denotes |
IFN-γ |
| T24198 |
33662-33665 |
Protein |
denotes |
Th1 |
| T24202 |
33680-33687 |
Gene_expression |
denotes |
express |
| T24201 |
33680-33687 |
Gene_expression |
denotes |
express |
| T24204 |
33693-33699 |
Positive_regulation |
denotes |
levels |
| T24203 |
33693-33699 |
Positive_regulation |
denotes |
levels |
| T24199 |
33703-33708 |
Protein |
denotes |
SOCS1 |
| T24200 |
33713-33723 |
Protein |
denotes |
SOCS3 mRNA |
| T24205 |
33758-33763 |
Protein |
denotes |
STAT4 |
| T24210 |
33764-33774 |
Positive_regulation |
denotes |
activation |
| T24211 |
33778-33787 |
Negative_regulation |
denotes |
inhibited |
| T24206 |
33791-33796 |
Protein |
denotes |
SOCS3 |
| T24212 |
33797-33806 |
Positive_regulation |
denotes |
induction |
| T24207 |
33829-33833 |
Protein |
denotes |
IL-4 |
| T24208 |
33842-33847 |
Protein |
denotes |
STAT6 |
| T24209 |
33875-33880 |
Protein |
denotes |
SOCS1 |
| T24213 |
33881-33890 |
Positive_regulation |
denotes |
induction |
| T24214 |
33905-33910 |
Protein |
denotes |
SOCS1 |
| T24215 |
33915-33920 |
Protein |
denotes |
SOCS3 |
| T24216 |
33954-33957 |
Protein |
denotes |
Th1 |
| T24217 |
34034-34038 |
Protein |
denotes |
IL-4 |
| T24218 |
34039-34044 |
Protein |
denotes |
STAT6 |
| T24219 |
34053-34058 |
Protein |
denotes |
IL-12 |
| T24220 |
34059-34064 |
Protein |
denotes |
STAT4 |
| T24224 |
34190-34197 |
Gene_expression |
denotes |
express |
| T24221 |
34213-34230 |
Protein |
denotes |
SOCS3 transcripts |
| T24222 |
34240-34245 |
Protein |
denotes |
SOCS3 |
| T24225 |
34246-34256 |
Gene_expression |
denotes |
expression |
| T24223 |
34284-34287 |
Protein |
denotes |
IgE |
| T24226 |
34330-34335 |
Protein |
denotes |
SOCS1 |
| T24229 |
34336-34346 |
Gene_expression |
denotes |
expression |
| T24231 |
34352-34357 |
Positive_regulation |
denotes |
lower |
| T24227 |
34358-34363 |
Protein |
denotes |
SOCS3 |
| T24230 |
34364-34374 |
Gene_expression |
denotes |
expression |
| T24228 |
34378-34384 |
Protein |
denotes |
PB CD4 |
| T31023 |
34584-34588 |
Protein |
denotes |
CD4+ |
| T31024 |
34662-34667 |
Protein |
denotes |
IL-10 |
| T31025 |
34682-34687 |
Protein |
denotes |
IFN-γ |
| T31028 |
34688-34698 |
Gene_expression |
denotes |
production |
| T31026 |
34720-34725 |
Protein |
denotes |
STAT3 |
| T31029 |
34726-34741 |
Phosphorylation |
denotes |
phosphorylation |
| T31027 |
34770-34775 |
Protein |
denotes |
STAT3 |
| T31031 |
34776-34786 |
Positive_regulation |
denotes |
activation |
| T31030 |
34776-34786 |
Positive_regulation |
denotes |
activation |
| T31032 |
34802-34807 |
Protein |
denotes |
STAT3 |
| T31033 |
34846-34851 |
Protein |
denotes |
SOCS1 |
| T31034 |
34870-34875 |
Protein |
denotes |
SOCS3 |
| T31035 |
34992-34996 |
Protein |
denotes |
IL-6 |
| T31036 |
35203-35230 |
Protein |
denotes |
anti-IL-6 receptor antibody |
| T31037 |
35363-35367 |
Protein |
denotes |
IL-6 |
| T31040 |
35368-35377 |
Positive_regulation |
denotes |
dependent |
| T31038 |
35378-35383 |
Protein |
denotes |
STAT3 |
| T31039 |
35384-35394 |
Positive_regulation |
denotes |
activation |
| T31041 |
35428-35433 |
Protein |
denotes |
STAT3 |
| T31043 |
35434-35444 |
Positive_regulation |
denotes |
activation |
| T31044 |
35479-35488 |
Positive_regulation |
denotes |
induction |
| T31042 |
35496-35506 |
Protein |
denotes |
SOCS3 gene |
| R1000 |
T3801 |
T3804 |
themeOf |
CD80,binding |
| R1001 |
T3802 |
T3805 |
themeOf |
CD86,binding |
| R1002 |
T3803 |
T3806 |
themeOf |
engagement,block |
| R1003 |
T3803 |
T3807 |
themeOf |
engagement,block |
| R1004 |
T3804 |
T3806 |
causeOf |
binding,block |
| R1005 |
T3805 |
T3807 |
causeOf |
binding,block |
| R1006 |
T3811 |
T3820 |
themeOf |
IFN-γ,production |
| R1007 |
T3813 |
T3821 |
themeOf |
CD28,costimulation |
| R1008 |
T3815 |
T3823 |
themeOf |
STAT1,induction |
| R1009 |
T3815 |
T3825 |
themeOf |
STAT1,phosphorylation |
| R1010 |
T3816 |
T3824 |
themeOf |
STAT3,induction |
| R1011 |
T3816 |
T3826 |
themeOf |
STAT3,phosphorylation |
| R1012 |
T3817 |
T3823 |
causeOf |
IL-10,induction |
| R1013 |
T3817 |
T3824 |
causeOf |
IL-10,induction |
| R1014 |
T3817 |
T3837 |
causeOf |
IL-10,induction |
| R1015 |
T3817 |
T3838 |
causeOf |
IL-10,induction |
| R1016 |
T3818 |
T3827 |
themeOf |
SOCS1,expression |
| R1017 |
T3819 |
T3828 |
themeOf |
SOCS3 mRNA,expression |
| R1018 |
T3820 |
T3822 |
themeOf |
production,costimulation |
| R1019 |
T3821 |
T3833 |
themeOf |
costimulation,after |
| R10191 |
T20554 |
T20556 |
themeOf |
SOCS1 mRNA,expression |
| R10192 |
T20555 |
T20557 |
themeOf |
RA CD4+ T cells,expression |
| R10193 |
T20556 |
T20558 |
themeOf |
expression,High |
| R10194 |
T20557 |
T20559 |
themeOf |
expression,High |
| R10195 |
T20561 |
T20564 |
themeOf |
JAKs,inhibitors |
| R10196 |
T20563 |
T20565 |
themeOf |
SOCS3 proteins,inhibitors |
| R10197 |
T20569 |
T20571 |
themeOf |
IL-6,regulating |
| R10198 |
T20570 |
T20572 |
themeOf |
IL-10,regulating |
| R10199 |
T20573 |
T20579 |
causeOf |
SOCS1,inhibit |
| R1020 |
T3822 |
T3834 |
themeOf |
costimulation,after |
| R10200 |
T20576 |
T20578 |
causeOf |
IFN-γ,mediated |
| R10201 |
T20577 |
T20578 |
themeOf |
STAT1,mediated |
| R10202 |
T20578 |
T20579 |
themeOf |
mediated,inhibit |
| R10203 |
T20580 |
T20589 |
causeOf |
IL-10,induced |
| R10204 |
T20581 |
T20586 |
themeOf |
STAT3,activation |
| R10205 |
T20583 |
T20587 |
themeOf |
SOCS1,expression |
| R10206 |
T20584 |
T20588 |
themeOf |
SOCS3 mRNA,expression |
| R10207 |
T20586 |
T20589 |
themeOf |
activation,induced |
| R10208 |
T20591 |
T20595 |
themeOf |
SOCS1,levels |
| R10209 |
T20592 |
T20596 |
themeOf |
SOCS3 transcripts,levels |
| R1021 |
T3823 |
T3829 |
themeOf |
induction,investigated |
| R10210 |
T20594 |
T20597 |
themeOf |
Fig. 6a,control |
| R10211 |
T20598 |
T20603 |
themeOf |
SOCS1 mRNA,expression |
| R10212 |
T20604 |
T20607 |
themeOf |
STAT3,activation |
| R10213 |
T20605 |
T20609 |
themeOf |
SOCS1,abundance |
| R10214 |
T20607 |
T20608 |
themeOf |
activation,due |
| R1022 |
T3824 |
T3830 |
themeOf |
induction,investigated |
| R1023 |
T3825 |
T3835 |
themeOf |
phosphorylation,after |
| R1024 |
T3825 |
T3837 |
themeOf |
phosphorylation,induction |
| R1025 |
T3826 |
T3836 |
themeOf |
phosphorylation,after |
| R1026 |
T3826 |
T3838 |
themeOf |
phosphorylation,induction |
| R1027 |
T3827 |
T3831 |
themeOf |
expression,investigated |
| R1028 |
T3828 |
T3832 |
themeOf |
expression,investigated |
| R11398 |
T23908 |
T23912 |
themeOf |
CD28 ligands,expressed |
| R11399 |
T23909 |
T23913 |
themeOf |
CD80,expressed |
| R11400 |
T23910 |
T23914 |
themeOf |
CD86,expressed |
| R11401 |
T23911 |
T23915 |
themeOf |
MHC class II antigens,expressed |
| R11402 |
T23918 |
T23922 |
causeOf |
IL-10,inhibits |
| R11403 |
T23919 |
T23921 |
themeOf |
CD28 molecule,phosphorylation |
| R11404 |
T23919 |
T23920 |
partOf |
CD28 molecule,tyrosine |
| R11405 |
T23920 |
T23921 |
Site |
tyrosine,phosphorylation |
| R11406 |
T23921 |
T23922 |
themeOf |
phosphorylation,inhibits |
| R11407 |
T23925 |
T23929 |
themeOf |
IFN-γ,produce |
| R11408 |
T23926 |
T23930 |
themeOf |
CD3,produce |
| R11409 |
T23931 |
T23938 |
themeOf |
IL-10R1,expression |
| R11410 |
T23932 |
T23939 |
themeOf |
STAT3,activation |
| R11411 |
T23933 |
T23941 |
themeOf |
STAT3,phosphorylation |
| R11412 |
T23933 |
T23940 |
partOf |
STAT3,tyrosine |
| R11413 |
T23936 |
T23943 |
themeOf |
STAT3,phosphorylation |
| R11414 |
T23937 |
T23944 |
causeOf |
IL-10,inducible |
| R11415 |
T23938 |
T23945 |
themeOf |
expression,high-level |
| R11416 |
T23940 |
T23941 |
Site |
tyrosine,phosphorylation |
| R11417 |
T23941 |
T23942 |
themeOf |
phosphorylation,suppressed |
| R11418 |
T23943 |
T23944 |
themeOf |
phosphorylation,inducible |
| R11419 |
T23946 |
T23952 |
themeOf |
STAT3,phosphorylation |
| R11420 |
T23947 |
T23953 |
themeOf |
STAT1,phosphorylation |
| R11421 |
T23949 |
T23959 |
causeOf |
IL-6,induces |
| R11422 |
T23951 |
T23954 |
themeOf |
IFN-γ,production |
| R11423 |
T23952 |
T23955 |
themeOf |
phosphorylation,induces |
| R11424 |
T23953 |
T23956 |
themeOf |
phosphorylation,induces |
| R11425 |
T23954 |
T23957 |
themeOf |
production,inhibition |
| R11426 |
T23957 |
T23958 |
themeOf |
inhibition,resistance |
| R11427 |
T23958 |
T23959 |
themeOf |
resistance,induces |
| R11428 |
T23961 |
T23964 |
themeOf |
SOCS1,levels |
| R11429 |
T23962 |
T23965 |
themeOf |
SOCS3 transcripts,levels |
| R11430 |
T23969 |
T23971 |
themeOf |
STAT3,phosphorylation |
| R11431 |
T23970 |
T23972 |
themeOf |
SOCS1,induction |
| R11432 |
T23971 |
T23973 |
themeOf |
phosphorylation,induction |
| R11433 |
T23976 |
T23979 |
themeOf |
CD80,express |
| R11434 |
T23977 |
T23980 |
themeOf |
CD86 molecules,express |
| R11435 |
T23978 |
T23981 |
themeOf |
MHC class II antigens,express |
| R11436 |
T23982 |
T23986 |
causeOf |
IL-10,inhibiting |
| R11437 |
T23983 |
T23985 |
themeOf |
CD28,phosphorylation |
| R11438 |
T23983 |
T23984 |
partOf |
CD28,tyrosine |
| R11439 |
T23984 |
T23985 |
Site |
tyrosine,phosphorylation |
| R11440 |
T23985 |
T23986 |
themeOf |
phosphorylation,inhibiting |
| R11441 |
T23989 |
T23996 |
causeOf |
CD28,costimulated |
| R11442 |
T23989 |
T23997 |
causeOf |
CD28,costimulated |
| R11443 |
T23990 |
T23992 |
themeOf |
IFN-γ,production |
| R11444 |
T23991 |
T23993 |
themeOf |
IL-2,production |
| R11445 |
T23992 |
T23994 |
themeOf |
production,inhibition |
| R11446 |
T23992 |
T23996 |
themeOf |
production,costimulated |
| R11447 |
T23993 |
T23995 |
themeOf |
production,inhibition |
| R11448 |
T23993 |
T23997 |
themeOf |
production,costimulated |
| R11449 |
T23998 |
T23999 |
themeOf |
IL-10,produced |
| R11450 |
T24004 |
T24007 |
themeOf |
STAT3,inhibits |
| R11451 |
T24008 |
T24011 |
causeOf |
IL-10,mediated |
| R11452 |
T24009 |
T24010 |
themeOf |
STAT3,activation |
| R11453 |
T24010 |
T24011 |
themeOf |
activation,mediated |
| R11454 |
T24017 |
T24018 |
themeOf |
IgG Fc gamma receptor,ligation |
| R11455 |
T24026 |
T24028 |
themeOf |
STAT3,activation |
| R11456 |
T24027 |
T24029 |
themeOf |
IL-10R1,expression |
| R11457 |
T24029 |
T24030 |
themeOf |
expression,activation |
| R11458 |
T24031 |
T24037 |
causeOf |
IL-10,mediated |
| R11459 |
T24032 |
T24035 |
themeOf |
STAT3,activation |
| R11460 |
T24033 |
T24036 |
themeOf |
STAT3,phosphorylated |
| R11461 |
T24035 |
T24037 |
themeOf |
activation,mediated |
| R11462 |
T24038 |
T24043 |
themeOf |
STAT3,activated |
| R11463 |
T24049 |
T24053 |
themeOf |
STAT3,activation |
| R11464 |
T24050 |
T24054 |
themeOf |
IL-10,inhibition |
| R11465 |
T24052 |
T24056 |
themeOf |
serum IL-6,concentrations |
| R11466 |
T24053 |
T24055 |
themeOf |
activation,induced |
| R11467 |
T24053 |
T24057 |
themeOf |
activation,sustained |
| R11468 |
T24056 |
T24058 |
themeOf |
concentrations,induced |
| R11469 |
T24059 |
T24063 |
themeOf |
STAT3,induced |
| R11470 |
T24059 |
T24064 |
themeOf |
STAT3,secretion |
| R11471 |
T24061 |
T24065 |
themeOf |
IL-10,secretion |
| R11472 |
T24067 |
T24068 |
themeOf |
STAT3,defect |
| R11473 |
T24070 |
T24072 |
themeOf |
IL-10,augmented |
| R11474 |
T24078 |
T24082 |
themeOf |
IFN-γ,produced |
| R11475 |
T24078 |
T24084 |
themeOf |
IFN-γ,produce |
| R11476 |
T24079 |
T24083 |
themeOf |
IL-10,produced |
| R11477 |
T24079 |
T24085 |
themeOf |
IL-10,produce |
| R11478 |
T24086 |
T24093 |
causeOf |
IL-10,stimulate |
| R11479 |
T24087 |
T24091 |
themeOf |
STAT3,activation |
| R11480 |
T24088 |
T24092 |
causeOf |
IFN-γ,induce |
| R11481 |
T24089 |
T24092 |
themeOf |
SOCS1 protein,induce |
| R11482 |
T24091 |
T24093 |
themeOf |
activation,stimulate |
| R11483 |
T24095 |
T24096 |
themeOf |
STAT3,activation |
| R11484 |
T24097 |
T24098 |
themeOf |
STAT3,expressed |
| R11485 |
T24101 |
T24102 |
themeOf |
Fc gamma receptor type I,expression |
| R11486 |
T24103 |
T24106 |
themeOf |
STAT3,activated |
| R11487 |
T24105 |
T24107 |
themeOf |
STAT3,activation |
| R11488 |
T24110 |
T24113 |
themeOf |
Src homology phosphatase-2 binding site,mutated |
| R11489 |
T24111 |
T24114 |
themeOf |
gp130,mutated |
| R11490 |
T24116 |
T24119 |
causeOf |
gp130,mediated |
| R11491 |
T24117 |
T24118 |
themeOf |
STAT3,activation |
| R11492 |
T24118 |
T24119 |
themeOf |
activation,mediated |
| R11493 |
T24124 |
T24127 |
themeOf |
SOCS1,levels |
| R11494 |
T24125 |
T24128 |
themeOf |
SOCS3,levels |
| R11495 |
T24130 |
T24136 |
themeOf |
JAK,activation |
| R11496 |
T24131 |
T24137 |
themeOf |
JAK,binding |
| R11497 |
T24134 |
T24138 |
themeOf |
Src homology phosphatase-2-binding domain of receptors,binding |
| R11498 |
T24136 |
T24139 |
themeOf |
activation,prevents |
| R11499 |
T24137 |
T24139 |
causeOf |
binding,prevents |
| R11500 |
T24140 |
T24144 |
themeOf |
SOCS1,induced |
| R11501 |
T24140 |
T24146 |
themeOf |
SOCS1,induced |
| R11502 |
T24140 |
T24148 |
themeOf |
SOCS1,induced |
| R11503 |
T24141 |
T24145 |
themeOf |
SOCS3,induced |
| R11504 |
T24141 |
T24147 |
themeOf |
SOCS3,induced |
| R11505 |
T24141 |
T24149 |
themeOf |
SOCS3,induced |
| R11506 |
T24142 |
T24146 |
causeOf |
IL-6,induced |
| R11507 |
T24142 |
T24147 |
causeOf |
IL-6,induced |
| R11508 |
T24143 |
T24148 |
causeOf |
IL-10,induced |
| R11509 |
T24143 |
T24149 |
causeOf |
IL-10,induced |
| R11510 |
T24150 |
T24155 |
themeOf |
SOCS3,lacking |
| R11511 |
T24151 |
T24156 |
themeOf |
SOCS1,lacking |
| R11512 |
T24157 |
T24161 |
themeOf |
SOCS3,deficient |
| R11513 |
T24158 |
T24162 |
themeOf |
SOCS3,deficiency |
| R11514 |
T24159 |
T24163 |
themeOf |
SOCS1,deficiency |
| R11515 |
T24160 |
T24164 |
themeOf |
STAT3,activation |
| R11516 |
T24163 |
T24165 |
themeOf |
deficiency,deficiency |
| R11517 |
T24166 |
T24169 |
themeOf |
SOCS3,deficient |
| R11518 |
T24174 |
T24182 |
themeOf |
SOCS1,expression |
| R11519 |
T24177 |
T24187 |
causeOf |
IL-10,mediated |
| R11520 |
T24178 |
T24183 |
themeOf |
STAT3,activation |
| R11521 |
T24179 |
T24184 |
themeOf |
SOCS3,expression |
| R11522 |
T24180 |
T24185 |
themeOf |
STAT3,activation |
| R11523 |
T24182 |
T24186 |
themeOf |
expression,Increased |
| R11524 |
T24183 |
T24187 |
themeOf |
activation,mediated |
| R11525 |
T24184 |
T24188 |
themeOf |
expression,defective |
| R11526 |
T24189 |
T24195 |
themeOf |
SOCS1,induction |
| R11527 |
T24191 |
T24196 |
themeOf |
IFN-γ,produce |
| R11528 |
T24193 |
T24197 |
themeOf |
IFN-γ,produce |
| R11529 |
T24199 |
T24201 |
themeOf |
SOCS1,express |
| R11530 |
T24199 |
T24203 |
themeOf |
SOCS1,levels |
| R11531 |
T24200 |
T24202 |
themeOf |
SOCS3 mRNA,express |
| R11532 |
T24200 |
T24204 |
themeOf |
SOCS3 mRNA,levels |
| R11533 |
T24205 |
T24210 |
themeOf |
STAT4,activation |
| R11534 |
T24206 |
T24212 |
themeOf |
SOCS3,induction |
| R11535 |
T24209 |
T24213 |
themeOf |
SOCS1,induction |
| R11536 |
T24210 |
T24211 |
themeOf |
activation,inhibited |
| R11537 |
T24221 |
T24224 |
themeOf |
SOCS3 transcripts,express |
| R11538 |
T24222 |
T24225 |
themeOf |
SOCS3,expression |
| R11539 |
T24226 |
T24229 |
themeOf |
SOCS1,expression |
| R11540 |
T24227 |
T24230 |
themeOf |
SOCS3,expression |
| R11541 |
T24230 |
T24231 |
themeOf |
expression,lower |
| R16245 |
T31025 |
T31028 |
themeOf |
IFN-γ,production |
| R16246 |
T31026 |
T31029 |
themeOf |
STAT3,phosphorylation |
| R16247 |
T31027 |
T31030 |
themeOf |
STAT3,activation |
| R16248 |
T31028 |
T31031 |
themeOf |
production,activation |
| R16249 |
T31037 |
T31040 |
causeOf |
IL-6,dependent |
| R16250 |
T31038 |
T31039 |
themeOf |
STAT3,activation |
| R16251 |
T31039 |
T31040 |
themeOf |
activation,dependent |
| R16252 |
T31041 |
T31043 |
themeOf |
STAT3,activation |
| R16253 |
T31042 |
T31044 |
themeOf |
SOCS3 gene,induction |
| R3192 |
T6871 |
T6872 |
themeOf |
serum CRP,elevated |
| R4425 |
T8712 |
T8713 |
themeOf |
IL-10R1,expression |
| R4788 |
T9782 |
T9785 |
themeOf |
SOCS1,expression |
| R4789 |
T9783 |
T9786 |
themeOf |
SOCS3,expression |
| R4790 |
T9784 |
T9787 |
themeOf |
β-actin,expression |
| R5484 |
T11029 |
T11039 |
causeOf |
serum IL-6,effect |
| R5485 |
T11030 |
T11035 |
themeOf |
STAT,phosphorylation |
| R5486 |
T11032 |
T11036 |
themeOf |
goat anti-IL-6 polyclonal antibody,neutralizing |
| R5487 |
T11033 |
T11037 |
themeOf |
IgG,neutralizing |
| R5488 |
T11034 |
T11038 |
themeOf |
IgG,neutralizing |
| R5489 |
T11035 |
T11039 |
themeOf |
phosphorylation,effect |
| R5490 |
T11040 |
T11043 |
themeOf |
STAT1,phosphorylation |
| R5491 |
T11040 |
T11042 |
partOf |
STAT1,Tyrosine |
| R5492 |
T11041 |
T11044 |
themeOf |
STAT3,phosphorylation |
| R5493 |
T11041 |
T11042 |
partOf |
STAT3,Tyrosine |
| R5494 |
T11042 |
T11043 |
Site |
Tyrosine,phosphorylation |
| R5495 |
T11042 |
T11044 |
Site |
Tyrosine,phosphorylation |
| R5496 |
T11048 |
T11049 |
themeOf |
horseradish peroxidase-conjugated anti-rabbit IgG antibody,binding |
| R5497 |
T11050 |
T11052 |
themeOf |
STAT,phosphorylation |
| R5498 |
T11051 |
T11053 |
themeOf |
STAT protein,phosphorylation |
| R5499 |
T11055 |
T11056 |
themeOf |
STAT1,phosophorylation |
| R5500 |
T11056 |
T11057 |
themeOf |
phosophorylation,control |
| R6395 |
T13006 |
T13009 |
themeOf |
IL-10,Resistance |
| R6396 |
T13007 |
T13010 |
themeOf |
IFN-γ,production |
| R6397 |
T13010 |
T13011 |
themeOf |
production,inhibition |
| R6398 |
T13013 |
T13016 |
themeOf |
CD28,phosphorylation |
| R6399 |
T13013 |
T13015 |
partOf |
CD28,tyrosine |
| R6400 |
T13014 |
T13017 |
themeOf |
phosphatidylinositol 3-kinase,binding |
| R6401 |
T13015 |
T13016 |
Site |
tyrosine,phosphorylation |
| R6402 |
T13016 |
T13018 |
themeOf |
phosphorylation,inhibiting |
| R6403 |
T13017 |
T13019 |
themeOf |
binding,inhibiting |
| R6404 |
T13026 |
T13027 |
themeOf |
IFN-γ,production |
| R6405 |
T13029 |
T13031 |
themeOf |
IFN-γ,production |
| R6406 |
T13031 |
T13032 |
themeOf |
production,inhibited |
| R6407 |
T13034 |
T13036 |
themeOf |
IFN-γ,produce |
| R6408 |
T13037 |
T13043 |
themeOf |
IFN-γ,production |
| R6409 |
T13044 |
T13048 |
themeOf |
IFN-γ,production |
| R6410 |
T13045 |
T13049 |
themeOf |
Fig. 2a,production |
| R6411 |
T13046 |
T13050 |
themeOf |
IL-10,production |
| R6412 |
T13047 |
T13051 |
themeOf |
IFN-γ,production |
| R6413 |
T13060 |
T13061 |
themeOf |
IL-2,production |
| R6414 |
T13061 |
T13062 |
themeOf |
production,affected |
| R651 |
T1090 |
T1092 |
themeOf |
interferon gamma,production |
| R652 |
T1092 |
T1093 |
themeOf |
production,inhibition |
| R653 |
T1094 |
T1096 |
causeOf |
IL-10,inhibiting |
| R654 |
T1095 |
T1096 |
themeOf |
CD28,inhibiting |
| R655 |
T1098 |
T1105 |
themeOf |
interferon gamma,amounts |
| R656 |
T1099 |
T1103 |
themeOf |
CD3,produce |
| R657 |
T1100 |
T1104 |
themeOf |
CD28,produce |
| R658 |
T1102 |
T1106 |
themeOf |
type 1 IL-10 receptor,expression |
| R659 |
T1106 |
T1107 |
themeOf |
expression,increased |
| R660 |
T1112 |
T1115 |
causeOf |
IL-10,inhibition |
| R661 |
T1113 |
T1114 |
themeOf |
interferon gamma,production |
| R662 |
T1114 |
T1115 |
themeOf |
production,inhibition |
| R663 |
T1115 |
T1116 |
themeOf |
inhibition,reduced |
| R7451 |
T14821 |
T14822 |
themeOf |
RA CD4+ T cells,expression |
| R7452 |
T14822 |
T14823 |
themeOf |
expression,Increased |
| R7453 |
T14825 |
T14826 |
themeOf |
IL-10R1,expression |
| R7454 |
T14827 |
T14831 |
themeOf |
IL-10,inhibition |
| R7455 |
T14829 |
T14832 |
themeOf |
IL-10R1,expression |
| R7456 |
T14834 |
T14836 |
themeOf |
IL-10R1,expression |
| R7457 |
T14836 |
T14837 |
themeOf |
expression,increased |
| R7952 |
T16047 |
T16054 |
causeOf |
IL-10,mediated |
| R7953 |
T16047 |
T16055 |
causeOf |
IL-10,mediated |
| R7954 |
T16048 |
T16050 |
themeOf |
STAT3,phosphorylation |
| R7955 |
T16049 |
T16051 |
themeOf |
RA CD4+ T cells,phosphorylation |
| R7956 |
T16050 |
T16052 |
themeOf |
phosphorylation,Defective |
| R7957 |
T16050 |
T16054 |
themeOf |
phosphorylation,mediated |
| R7958 |
T16051 |
T16053 |
themeOf |
phosphorylation,Defective |
| R7959 |
T16051 |
T16055 |
themeOf |
phosphorylation,mediated |
| R7960 |
T16056 |
T16060 |
themeOf |
IL-10R,interaction |
| R7961 |
T16057 |
T16060 |
themeOf |
IL-10,interaction |
| R7962 |
T16058 |
T16061 |
partOf |
STAT1,tyrosine |
| R7963 |
T16059 |
T16061 |
partOf |
STAT3,tyrosine |
| R7964 |
T16062 |
T16066 |
themeOf |
STAT3,deficient |
| R7965 |
T16065 |
T16067 |
themeOf |
STAT3,overexpression |
| R7966 |
T16067 |
T16068 |
themeOf |
overexpression,overexpression |
| R7967 |
T16069 |
T16073 |
themeOf |
STAT1,induction |
| R7968 |
T16069 |
T16075 |
themeOf |
STAT1,phosphorylation |
| R7969 |
T16070 |
T16074 |
themeOf |
STAT3,induction |
| R7970 |
T16070 |
T16076 |
themeOf |
STAT3,phosphorylation |
| R7971 |
T16071 |
T16073 |
causeOf |
IL-10,induction |
| R7972 |
T16071 |
T16074 |
causeOf |
IL-10,induction |
| R7973 |
T16071 |
T16077 |
causeOf |
IL-10,induction |
| R7974 |
T16071 |
T16078 |
causeOf |
IL-10,induction |
| R7975 |
T16075 |
T16077 |
themeOf |
phosphorylation,induction |
| R7976 |
T16076 |
T16078 |
themeOf |
phosphorylation,induction |
| R7977 |
T16079 |
T16083 |
themeOf |
STAT3,phosphorylation |
| R7978 |
T16080 |
T16085 |
themeOf |
IL-10,activation |
| R7979 |
T16082 |
T16084 |
causeOf |
"Fig. 4a,4b",induced |
| R7980 |
T16083 |
T16084 |
themeOf |
phosphorylation,induced |
| R7981 |
T16083 |
T16086 |
themeOf |
phosphorylation,induced |
| R7982 |
T16085 |
T16086 |
causeOf |
activation,induced |
| R7983 |
T16087 |
T16090 |
themeOf |
STAT3,phosphorylated |
| R7984 |
T16089 |
T16091 |
themeOf |
STAT3,phosphorylation |
| R7985 |
T16091 |
T16092 |
themeOf |
phosphorylation,detectable |
| R7986 |
T16093 |
T16094 |
themeOf |
STAT3,phosphorylation |
| R7987 |
T16094 |
T16095 |
themeOf |
phosphorylation,augmented |
| R7988 |
T16096 |
T16102 |
themeOf |
STAT3,phosphorylation |
| R7989 |
T16097 |
T16107 |
causeOf |
IL-10,induced |
| R7990 |
T16098 |
T16103 |
themeOf |
STAT3,phosphorylation |
| R7991 |
T16102 |
T16104 |
themeOf |
phosphorylation,found |
| R7992 |
T16103 |
T16105 |
themeOf |
phosphorylation,found |
| R7993 |
T16103 |
T16106 |
themeOf |
phosphorylation,defective |
| R7994 |
T16103 |
T16107 |
themeOf |
phosphorylation,induced |
| R7995 |
T16108 |
T16112 |
themeOf |
STAT1,phosphorylation |
| R7996 |
T16112 |
T16113 |
themeOf |
phosphorylation,detected |
| R7997 |
T16112 |
T16114 |
themeOf |
phosphorylation,IL-10-induced |
| R7998 |
T16115 |
T16121 |
themeOf |
STAT3,IL-10-activated |
| R7999 |
T16116 |
T16122 |
themeOf |
STAT,IL-10-activated |
| R8000 |
T16120 |
T16123 |
themeOf |
STAT3,phosphorylation |
| R8909 |
T18300 |
T18306 |
causeOf |
IL-6,mediated |
| R8910 |
T18301 |
T18304 |
themeOf |
STAT3,phosphorylation |
| R8911 |
T18302 |
T18305 |
themeOf |
IL-10,effect |
| R8912 |
T18304 |
T18306 |
themeOf |
phosphorylation,mediated |
| R8913 |
T18305 |
T18307 |
themeOf |
effect,inhibition |
| R8914 |
T18308 |
T18313 |
themeOf |
STAT3,activated |
| R8915 |
T18312 |
T18314 |
themeOf |
STAT3,activation |
| R8916 |
T18314 |
T18315 |
themeOf |
activation,induces |
| R8917 |
T18318 |
T18321 |
themeOf |
IL-6,concentrations |
| R8918 |
T18319 |
T18322 |
themeOf |
STAT3,activation |
| R8919 |
T18320 |
T18323 |
themeOf |
IL-10,inhibition |
| R8920 |
T18322 |
T18324 |
themeOf |
activation,responsible |
| R8921 |
T18325 |
T18329 |
themeOf |
STAT1,phosphorylation |
| R8922 |
T18325 |
T18331 |
themeOf |
STAT1,activated |
| R8923 |
T18326 |
T18330 |
themeOf |
STAT3,phosphorylation |
| R8924 |
T18326 |
T18332 |
themeOf |
STAT3,activated |
| R8925 |
T18327 |
T18331 |
causeOf |
IL-6,activated |
| R8926 |
T18327 |
T18332 |
causeOf |
IL-6,activated |
| R8927 |
T18327 |
T18333 |
causeOf |
IL-6,activated |
| R8928 |
T18327 |
T18334 |
causeOf |
IL-6,activated |
| R8929 |
T18329 |
T18333 |
themeOf |
phosphorylation,activated |
| R8930 |
T18330 |
T18334 |
themeOf |
phosphorylation,activated |
| R8931 |
T18336 |
T18338 |
themeOf |
anti-IL-6 antibody or control antibody,neutralizing |
| R8932 |
T18337 |
T18339 |
themeOf |
STAT,phosphorylation |
| R8933 |
T18340 |
T18346 |
themeOf |
STAT3,phosphorylation |
| R8934 |
T18340 |
T18345 |
partOf |
STAT3,tyrosine |
| R8935 |
T18341 |
T18347 |
themeOf |
STAT1,phosphorylation |
| R8936 |
T18341 |
T18345 |
partOf |
STAT1,tyrosine |
| R8937 |
T18342 |
T18348 |
themeOf |
STAT3,activation |
| R8938 |
T18343 |
T18349 |
themeOf |
IL-6,neutralization |
| R8939 |
T18344 |
T18350 |
themeOf |
Fig. 5a,neutralization |
| R8940 |
T18345 |
T18346 |
Site |
tyrosine,phosphorylation |
| R8941 |
T18345 |
T18347 |
Site |
tyrosine,phosphorylation |
| R8942 |
T18346 |
T18351 |
themeOf |
phosphorylation,induce |
| R8943 |
T18347 |
T18352 |
themeOf |
phosphorylation,induce |
| R8944 |
T18348 |
T18353 |
themeOf |
activation,abolished |
| R8945 |
T18348 |
T18354 |
themeOf |
activation,abolished |
| R8946 |
T18349 |
T18353 |
causeOf |
neutralization,abolished |
| R8947 |
T18350 |
T18354 |
causeOf |
neutralization,abolished |
| R8948 |
T18357 |
T18362 |
themeOf |
STAT1,activation |
| R8949 |
T18358 |
T18363 |
themeOf |
IL-6,concentrations |
| R8950 |
T18359 |
T18364 |
themeOf |
STAT1,activation |
| R8951 |
T18360 |
T18365 |
themeOf |
STAT3,activation |
| R8952 |
T18361 |
T18366 |
themeOf |
STAT1,inhibitors |
| R8953 |
T18362 |
T18368 |
themeOf |
activation,lack |
| R8954 |
T18364 |
T18369 |
themeOf |
activation,required |
| R8955 |
T18366 |
T18367 |
themeOf |
inhibitors,present |
| R8956 |
T18371 |
T18375 |
causeOf |
IL-10,inhibit |
| R8957 |
T18372 |
T18374 |
themeOf |
IFN-γ,production |
| R8958 |
T18374 |
T18375 |
themeOf |
production,inhibit |
| R8959 |
T18379 |
T18380 |
themeOf |
IFN-γ,production |
| R8960 |
T18381 |
T18386 |
causeOf |
IL-10,inhibition |
| R8961 |
T18382 |
T18385 |
themeOf |
IFN-γ,production |
| R8962 |
T18385 |
T18386 |
themeOf |
production,inhibition |
| R8963 |
T18386 |
T18387 |
themeOf |
inhibition,reduced |
| R958 |
T3706 |
T3711 |
themeOf |
IL-10,binds |
| R959 |
T3706 |
T3712 |
themeOf |
IL-10,binds |
| R960 |
T3706 |
T3713 |
themeOf |
IL-10,binds |
| R961 |
T3707 |
T3712 |
themeOf |
IL-10 receptor,binds |
| R962 |
T3708 |
T3713 |
themeOf |
IL-10R,binds |
| R963 |
T3709 |
T3714 |
themeOf |
type 1 IL-10R,ligand-binding |
| R964 |
T3710 |
T3715 |
themeOf |
IL-10R1,ligand-binding |
| R965 |
T3725 |
T3729 |
causeOf |
IL-10,induces |
| R966 |
T3726 |
T3728 |
themeOf |
latent transcriptional factors,activation |
| R967 |
T3726 |
T3727 |
partOf |
latent transcriptional factors,tyrosine |
| R968 |
T3728 |
T3729 |
themeOf |
activation,induces |
| R969 |
T3730 |
T3732 |
themeOf |
STAT1,phosphorylation |
| R970 |
T3730 |
T3735 |
themeOf |
STAT1,translocate |
| R971 |
T3731 |
T3733 |
themeOf |
STAT3 proteins,phosphorylation |
| R972 |
T3731 |
T3736 |
themeOf |
STAT3 proteins,translocate |
| R973 |
T3734 |
T3735 |
locationOf |
nucleus,translocate |
| R974 |
T3734 |
T3736 |
locationOf |
nucleus,translocate |
| R975 |
T3738 |
T3741 |
themeOf |
STAT3,deficient |
| R976 |
T3739 |
T3742 |
themeOf |
STAT3,activation |
| R977 |
T3744 |
T3745 |
themeOf |
JAK kinase,inhibitors |
| R978 |
T3747 |
T3751 |
themeOf |
IL-10,regulating |
| R979 |
T3748 |
T3752 |
themeOf |
IL-6,regulating |
| R980 |
T3756 |
T3757 |
themeOf |
IL-6,produced |
| R981 |
T3758 |
T3759 |
themeOf |
IL-10,produced |
| R982 |
T3758 |
T3760 |
themeOf |
IL-10,expression |
| R983 |
T3761 |
T3762 |
themeOf |
IL-10,modulated |
| R984 |
T3766 |
T3769 |
themeOf |
IL-10R1,expression |
| R985 |
T3769 |
T3770 |
themeOf |
expression,decreased |
| R986 |
T3773 |
T3782 |
themeOf |
MHC class II antigens,linkage |
| R987 |
T3773 |
T3783 |
themeOf |
MHC class II antigens,linkage |
| R988 |
T3777 |
T3784 |
themeOf |
DRB1,linkage |
| R989 |
T3778 |
T3785 |
themeOf |
MHC class II molecules,expression |
| R990 |
T3779 |
T3782 |
themeOf |
CD28 ligands,linkage |
| R991 |
T3779 |
T3784 |
themeOf |
CD28 ligands,linkage |
| R992 |
T3779 |
T3786 |
themeOf |
CD28 ligands,expression |
| R993 |
T3780 |
T3787 |
themeOf |
CD80,expression |
| R994 |
T3781 |
T3783 |
themeOf |
CD86,linkage |
| R995 |
T3781 |
T3788 |
themeOf |
CD86,expression |
| R996 |
T3792 |
T3794 |
themeOf |
interferon gamma,release |
| R997 |
T3793 |
T3795 |
themeOf |
IFN,release |
| R998 |
T3797 |
T3798 |
themeOf |
rheumatoid factor,production |
| R999 |
T3800 |
T3803 |
themeOf |
CD28,engagement |
