bionlp-st-ge-2016-test-ihmc  

PMC:3589482 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue Negation
T731 0-32 Protein denotes The Transcription Factor C/EBP-β
T758 59-105 Transcription denotes LPS-Inducible Transcription of Murine SerpinB2
T749 87-105 Protein denotes of Murine SerpinB2
T740 156-214 Protein denotes SerpinB2 or plasminogen activator inhibitor type 2 (PAI-2)
T744 168-214 Protein denotes plasminogen activator inhibitor type 2 (PAI-2)
T739 208-213 Protein denotes PAI-2
T723 236-247 Entity denotes macrophages
T705 336-346 Entity denotes macrophage
T733 372-397 Entity denotes of plasminogen activators
T745 375-386 Protein denotes plasminogen
T709 399-424 Entity denotes Lipopolysaccharide (LPS),
T750 419-422 Entity denotes LPS
T711 444-453 Entity denotes endotoxin
T748 466-474 Protein denotes SerpinB2
T759 466-485 Gene_expression denotes SerpinB2 expression
T714 490-521 Protein denotes the toll-like receptor 4 (TLR4)
T715 516-520 Protein denotes TLR4
T760 553-581 Localization denotes 24 hrs in murine macrophages
T719 553-581 Protein denotes 24 hrs in murine macrophages
T724 563-581 Entity denotes murine macrophages
T729 590-634 Entity denotes the LPS-regulated SerpinB2 promoter regions,
T741 594-607 Entity denotes LPS-regulated
T720 608-616 Protein denotes SerpinB2
T743 709-736 Protein denotes of the murine SerpinB2 gene
T753 723-731 Protein denotes SerpinB2
T726 771-789 Entity denotes murine macrophages
T722 820-823 Entity denotes DNA
T751 886-903 Protein denotes of the human gene
T761 1007-1057 Binding denotes the human SERPINB2 promoter conserved in the mouse
T738 1007-1057 Entity denotes the human SERPINB2 promoter conserved in the mouse
T752 1017-1025 Protein denotes SERPINB2
T725 1117-1122 Protein denotes C/EBP
T707 1142-1145 Entity denotes AMP
T716 1164-1167 Protein denotes CRE
T732 1173-1186 Entity denotes two activator
T742 1187-1203 Protein denotes protein 1 (AP-1)
T747 1198-1202 Protein denotes AP-1
T713 1225-1262 Entity denotes the murine SerpinB2 proximal promoter
T728 1236-1244 Protein denotes SerpinB2
T730 1277-1305 Entity denotes for optimal LPS-inducibility
T746 1349-1358 Entity denotes chromatin
T735 1411-1414 Entity denotes LPS
T757 1423-1495 Gene_expression denotes the formation of C/EBP-β containing complexes with the SerpinB2 promoter
T718 1437-1495 Protein denotes of C/EBP-β containing complexes with the SerpinB2 promoter
T737 1459-1495 Entity denotes complexes with the SerpinB2 promoter
T754 1474-1495 Entity denotes the SerpinB2 promoter
T710 1478-1486 Protein denotes SerpinB2
T736 1532-1543 Entity denotes LPS-induced
T717 1544-1552 Protein denotes SerpinB2
T712 1590-1597 Protein denotes C/EBP-β
T708 1609-1637 Entity denotes embryonic fibroblasts (MEFs)
T721 1632-1636 Protein denotes MEFs
T734 1642-1690 Entity denotes primary C/EBP-β-deficient peritoneal macrophages
T706 1738-1755 Protein denotes C/EBP-β-dependent
T755 1738-1813 Regulation denotes C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression
T762 1738-1813 Regulation denotes C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression
T756 1767-1813 Gene_expression denotes of inflammation-associated SerpinB2 expression
T727 1794-1802 Protein denotes SerpinB2
T2430 1930-1950 Entity denotes of foreign molecules
T2448 2150-2159 Protein denotes cytokines
T2456 2164-2193 Protein denotes other inducible gene products
T2375 2204-2218 Entity denotes by macrophages
T2409 2236-2287 Entity denotes the gram-negative bacterial cell wall component LPS
T2386 2264-2273 Entity denotes cell wall
T2428 2292-2303 Entity denotes macrophages
T2396 2503-2506 Entity denotes LPS
T2432 2507-2547 Protein denotes inducible macrophage gene products known
T2394 2517-2527 Entity denotes macrophage
T2392 2551-2617 Protein denotes the ovalbumin-like serine protease inhibitor (ov-serpin) SerpinB2,
T2387 2551-2617 Protein denotes the ovalbumin-like serine protease inhibitor (ov-serpin) SerpinB2,
T2453 2570-2576 Entity denotes serine
T2389 2586-2607 Entity denotes inhibitor (ov-serpin)
T2379 2597-2606 Protein denotes ov-serpin
T2418 2638-2648 Entity denotes macrophage
T2416 2675-2683 Protein denotes SerpinB2
T2417 2711-2769 Entity denotes inhibitor of urokinase-type plasminogen activator (uPA)[6]
T2401 2724-2766 Protein denotes urokinase-type plasminogen activator (uPA)
T2438 2762-2765 Protein denotes uPA
T2458 2777-2783 Entity denotes serine
T2463 2777-2903 Protein denotes serine protease involved in the degradation and turnover of the extracellular matrix through the activation of plasminogen [7]
T2462 2837-2861 Entity denotes the extracellular matrix
T2469 2870-2899 Positive_regulation denotes the activation of plasminogen
T2452 2885-2899 Protein denotes of plasminogen
T2422 2933-2941 Protein denotes SerpinB2
T2405 2962-2970 Entity denotes the cell
T2437 2975-2983 Protein denotes SerpinB2
T2479 3004-3048 Localization denotes a nonglycosylated intracellular protein [10]
T2465 3004-3048 Protein_modification denotes a nonglycosylated intracellular protein [10]
T2414 3004-3048 Protein denotes a nonglycosylated intracellular protein [10]
T2395 3022-3035 Entity denotes intracellular
T2407 3072-3085 Entity denotes intracellular
T2404 3096-3132 Protein denotes SerpinB2 in cell survival [11]–[17],
T2440 3267-3284 Protein denotes The SerpinB2 gene
T2467 3267-3385 Regulation denotes The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]
T2421 3271-3279 Protein denotes SerpinB2
T2411 3310-3328 Entity denotes cell type specific
T2420 3357-3366 Protein denotes cytokines
T2378 3371-3380 Protein denotes oncogenes
T2436 3406-3437 Protein denotes the most responsive genes known
T2427 3481-3489 Entity denotes LPS [31]
T2413 3558-3561 Entity denotes LPS
T2388 3627-3658 Protein denotes The toll-like receptor 4 (TLR4)
T2442 3653-3657 Protein denotes TLR4
T2398 3697-3700 Entity denotes LPS
T2484 3758-3827 Regulation denotes the initiation of innate immune responses, including cytokine release
T2408 3811-3819 Protein denotes cytokine
T2473 3829-3885 Binding denotes The binding of LPS to TLR4 on the surface of macrophages
T2385 3841-3847 Entity denotes of LPS
T2460 3848-3855 Protein denotes to TLR4
T2457 3871-3885 Entity denotes of macrophages
T2474 3895-3931 Binding denotes the recruitment of adaptor molecules
T2403 3911-3931 Entity denotes of adaptor molecules
T2466 3936-3969 Positive_regulation denotes the activation of protein kinases
T2451 3951-3969 Protein denotes of protein kinases
T2372 4016-4021 Protein denotes NF-κB
T2435 4024-4031 Entity denotes mitogen
T2477 4024-4063 Positive_regulation denotes mitogen-activated protein kinase (MAPK)
T2459 4042-4063 Protein denotes protein kinase (MAPK)
T2370 4058-4062 Protein denotes MAPK
T2426 4071-4101 Entity denotes phosphoinositide 3(PI3)-kinase
T2391 4071-4101 Protein denotes phosphoinositide 3(PI3)-kinase
T2424 4090-4093 Protein denotes PI3
T2445 4198-4201 Protein denotes p38
T2447 4198-4206 Protein denotes p38 MAPK
T2450 4208-4216 Protein denotes SerpinB2
T2478 4244-4276 Positive_regulation denotes whose expression was upregulated
T2454 4299-4309 Protein denotes IKKβ/NF-κB
T2441 4299-4309 Protein denotes IKKβ/NF-κB
T2419 4304-4309 Protein denotes NF-κB
T2455 4318-4327 Protein denotes MAPK/CREB
T2377 4318-4327 Protein denotes MAPK/CREB
T2412 4323-4327 Protein denotes CREB
T2410 4388-4410 Protein denotes SerpinB2 is distinctly
T2433 4426-4451 Protein denotes other LPS-inducible genes
T2380 4474-4477 Entity denotes LPS
T2406 4511-4516 Protein denotes IFN-γ
T2483 4511-4535 Positive_regulation denotes IFN-γ co-stimulation [4]
T2439 4573-4638 Entity denotes the SerpinB2 promoter responsible for LPS-dependent transcription
T2429 4577-4585 Protein denotes SerpinB2
T2481 4607-4638 Regulation denotes for LPS-dependent transcription
T2461 4611-4624 Entity denotes LPS-dependent
T2383 4642-4653 Entity denotes macrophages
T2402 4671-4674 Entity denotes LPS
T2431 4718-4739 Entity denotes the SerpinB2 promoter
T2443 4722-4730 Protein denotes SerpinB2
T2390 4776-4779 Entity denotes LPS
T2471 4776-4801 Positive_regulation denotes LPS induction of SerpinB2
T2470 4776-4801 Gene_expression denotes LPS induction of SerpinB2
T2476 4776-4830 Regulation denotes LPS induction of SerpinB2 is dependent upon cis-acting
T2475 4776-4830 Regulation denotes LPS induction of SerpinB2 is dependent upon cis-acting
T2444 4790-4801 Protein denotes of SerpinB2
T2384 4815-4830 Protein denotes upon cis-acting
T2374 4874-4885 Entity denotes nucleotides
T2434 4903-4932 Entity denotes the murine SerpinB2 promoter,
T2376 4914-4922 Protein denotes SerpinB2
T2480 4961-4986 Binding denotes upon a C/EBP binding site
T2371 4961-4986 Entity denotes upon a C/EBP binding site
T2399 4968-4973 Protein denotes C/EBP
T2382 5001-5008 Protein denotes C/EBP-β
T2468 5001-5044 Binding denotes C/EBP-β directly bound to this site in vivo
T2472 5074-5106 Gene_expression denotes constitutive SerpinB2 expression
T2373 5087-5095 Protein denotes SerpinB2
T2415 5111-5119 Protein denotes SerpinB2
T2486 5111-5136 Gene_expression denotes SerpinB2 induction by LPS
T2485 5111-5136 Positive_regulation denotes SerpinB2 induction by LPS
T2397 5130-5136 Entity denotes by LPS
T2482 5138-5254 Regulation denotes Importantly, a C/EBP-β phospho-acceptor site was found to negatively regulate LPS-induced SerpinB2 promoter activity
T2423 5151-5182 Entity denotes a C/EBP-β phospho-acceptor site
T2400 5153-5160 Protein denotes C/EBP-β
T2446 5169-5177 Entity denotes acceptor
T2449 5216-5227 Entity denotes LPS-induced
T2381 5228-5236 Protein denotes SerpinB2
T2425 5228-5245 Entity denotes SerpinB2 promoter
T2487 5306-5357 Regulation denotes the transcriptional regulation of the SerpinB2 gene
T2393 5337-5357 Protein denotes of the SerpinB2 gene
T2464 5344-5352 Protein denotes SerpinB2
T3313 5967-5977 Entity denotes penicillin
T3303 5967-6000 Entity denotes penicillin/streptomycin/glutamate
T3297 5967-6000 Entity denotes penicillin/streptomycin/glutamate
T3308 5978-5990 Entity denotes streptomycin
T3310 6021-6051 Entity denotes Primary peritoneal macrophages
T3315 6021-6150 Binding denotes Primary peritoneal macrophages were obtained by injecting C57BL/6 mice with 3% thioglycollate broth followed by peritoneal lavage
T3301 6100-6114 Entity denotes thioglycollate
T3305 6194-6197 Protein denotes F12
T3304 6205-6214 Protein denotes Gibco BRL
T3299 6261-6279 Entity denotes lipopolysaccharide
T3306 6346-6354 Entity denotes LPS-free
T3312 6362-6376 Entity denotes Cell viability
T3309 6402-6421 Entity denotes trypan blue (Sigma)
T3311 6415-6420 Protein denotes Sigma
T3314 6483-6531 Regulation denotes exclude Mycoplasma infection by nuclear staining
T3296 6559-6564 Protein denotes Sigma
T3300 6584-6605 Protein denotes Detection Kit (Lonza)
T3307 6607-6641 Entity denotes Bacterial lipopolysaccharide (LPS)
T3302 6637-6640 Entity denotes LPS
T3298 6696-6701 Protein denotes Sigma
T3714 6704-6737 Protein denotes Real-time Quantitative PCR (qPCR)
T3715 6732-6736 Protein denotes qPCR
T3712 6749-6766 Protein denotes Mini Kit (Qiagen)
T3716 6787-6796 Protein denotes total RNA
T3718 6797-6807 Entity denotes from cells
T3708 6813-6827 Entity denotes cDNA synthesis
T3717 6837-6846 Protein denotes total RNA
T3709 6877-6936 Entity denotes TaqMan® Reverse Transcription Reagents (Applied Biosystems)
T3710 6963-6975 Protein denotes TaqMan® Gene
T3719 6963-6998 Gene_expression denotes TaqMan® Gene Expression 20X primers
T3707 7003-7037 Protein denotes Serpinb2/SerpinB2 (Mm00440905_m1),
T3713 7038-7059 Protein denotes Cebpb (Mm00843434_s1)
T3711 7064-7087 Protein denotes β-actin (Mm00607939_s1)
T4056 7111-7114 Entity denotes DNA
T4048 7137-7140 Entity denotes DNA
T4039 7150-7181 Entity denotes of the murine SerpinB2 promoter
T4044 7164-7172 Protein denotes SerpinB2
T4038 7211-7216 Entity denotes the p
T4049 7234-7237 Entity denotes pDB
T4037 7369-7394 Protein denotes exonuclease III digestion
T4054 7451-7547 Entity denotes genomic DNA isolated from a λFIXII (Stratagene) genomic library prepared from a 129 mouse strain
T4040 7642-7647 Entity denotes EcoRI
T4043 7679-7712 Entity denotes the transcription initiation site
T4041 7757-7760 Protein denotes Eco
T4053 7825-7840 Entity denotes EcoRI fragment,
T4047 7909-7937 Protein denotes restriction enzyme digestion
T4050 7958-8020 Protein denotes The nucleotide sequence of the 4480 bp murine SerpinB2 gene 5′
T4051 7962-7972 Entity denotes nucleotide
T4057 8004-8012 Protein denotes SerpinB2
T4046 8058-8071 Protein denotes the ABI PRISM
T4042 8142-8146 Protein denotes a PE
T4055 8209-8251 Protein denotes GenBank/EMBL/DDBJ Data Bank with Accession
T4045 8209-8251 Protein denotes GenBank/EMBL/DDBJ Data Bank with Accession
T4052 8212-8216 Protein denotes Bank
T4490 8336-8381 Entity denotes 10 mM Tris, 150 mM NaCl, 1%Triton X-100, 0.5%
T4485 8342-8360 Entity denotes Tris, 150 mM NaCl,
T4499 8348-8359 Entity denotes 150 mM NaCl
T4493 8389-8417 Entity denotes 0.5% deoxycholate, 0.1% SDS)
T4495 8408-8416 Protein denotes 0.1% SDS
T4481 8419-8427 Protein denotes proteins
T4497 8433-8460 Entity denotes separated on 4–12% Bis-Tris
T4482 8468-8485 Entity denotes gels (Invitrogen)
T4486 8506-8510 Entity denotes PVDF
T4494 8506-8520 Entity denotes PVDF membranes
T4483 8522-8531 Entity denotes Membranes
T4488 8574-8588 Entity denotes PBS-T (1X PBS,
T4478 8624-8642 Entity denotes primary antibodies
T4479 8690-8698 Protein denotes SerpinB2
T4480 8690-8709 Entity denotes SerpinB2 antibodies
T4500 8748-8825 Gene_expression denotes a purified recombinant GST-murine SerpinB2 fusion protein produced in E. coli
T4484 8748-8825 Protein denotes a purified recombinant GST-murine SerpinB2 fusion protein produced in E. coli
T4477 8838-8883 Entity denotes Other antibodies used for western blot assays
T4489 8864-8883 Entity denotes western blot assays
T4487 8893-8909 Protein denotes C/EBP-β (sc-150)
T4491 8940-8988 Protein denotes glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
T4498 8982-8987 Protein denotes GAPDH
T4496 8993-9004 Protein denotes α/β tubulin
T4492 9006-9010 Entity denotes Cell
T5409 9054-9088 Protein denotes of SerpinB2 Reporter Gene Plasmids
T5427 9093-9096 Protein denotes PCR
T5450 9125-9149 Entity denotes a Kpn I restriction site
T5431 9178-9183 Protein denotes Xho I
T5468 9215-9218 Protein denotes PCR
T5407 9237-9273 Entity denotes the SerpinB2 promoter (−3261 to +92)
T5443 9241-9249 Protein denotes SerpinB2
T5467 9345-9360 Protein denotes Basic (Promega)
T5405 9372-9382 Entity denotes pGLmP-3261
T5451 9373-9377 Protein denotes GLmP
T5464 9388-9394 Protein denotes EcoR I
T5445 9455-9496 Entity denotes the SerpinB2 promoter EcoR I site (−3261)
T5439 9455-9496 Entity denotes the SerpinB2 promoter EcoR I site (−3261)
T5424 9459-9467 Protein denotes SerpinB2
T5433 9477-9483 Protein denotes EcoR I
T5456 9500-9532 Entity denotes pGLmP-3261 to produce pGLmP-4480
T5476 9501-9505 Protein denotes GLmP
T5435 9522-9532 Entity denotes pGLmP-4480
T5444 9523-9527 Protein denotes GLmP
T5399 9552-9560 Protein denotes SerpinB2
T5479 9552-9591 Protein denotes SerpinB2 luciferase reporter constructs
T5466 9593-9594 Entity denotes p
T5403 9594-9598 Protein denotes GLmP
T5434 9605-9606 Entity denotes p
T5463 9606-9610 Protein denotes GLmP
T5478 9617-9620 Protein denotes pGL
T5393 9621-9634 Protein denotes P-1686, pGLmP
T5455 9641-9642 Entity denotes p
T5413 9642-9646 Protein denotes GLmP
T5446 9652-9657 Protein denotes pGLmP
T5401 9666-9671 Protein denotes pGLmP
T5425 9705-9710 Protein denotes pGLmP
T5472 9721-9727 Protein denotes EcoR I
T5397 9721-9816 Protein denotes EcoR I and a second restriction enzyme (Sfi I, Apa I, BstX I, Bsu36 I, Pac I, Hae III and Apo I
T5414 9753-9767 Protein denotes enzyme (Sfi I,
T5422 9761-9766 Protein denotes Sfi I
T5481 9775-9781 Protein denotes BstX I
T5449 9783-9790 Protein denotes Bsu36 I
T5411 9792-9797 Protein denotes Pac I
T5462 9799-9806 Protein denotes Hae III
T5480 9811-9816 Protein denotes Apo I
T5395 9883-9885 Entity denotes T4
T5482 9883-9906 Protein denotes T4 DNA polymerase (NEB)
T5390 9902-9905 Protein denotes NEB
T5430 9944-9946 Entity denotes T4
T5420 9944-9957 Protein denotes T4 DNA ligase
T5417 9963-9966 Protein denotes PCR
T5477 10016-10052 Entity denotes the murine SerpinB2 promoter regions
T5416 10027-10035 Protein denotes SerpinB2
T5437 10122-10147 Protein denotes Basic to produce pGLmP-87
T5440 10178-10182 Protein denotes pGL3
T5421 10178-10198 Protein denotes pGL3 Basic (Promega)
T5423 10200-10210 Protein denotes Luciferase
T5469 10255-10291 Entity denotes the SerpinB2 promoter LPS-responsive
T5461 10259-10267 Protein denotes SerpinB2
T5398 10292-10312 Entity denotes regions E box, PU.1,
T5415 10307-10311 Protein denotes PU.1
T5453 10323-10328 Protein denotes C/EBP
T5412 10331-10335 Protein denotes GLmP
T5410 10362-10375 Protein denotes pGLmP-539mOct
T5396 10363-10367 Protein denotes GLmP
T5438 10380-10395 Protein denotes pGLmP-539mC/EBP
T5389 10381-10385 Protein denotes GLmP
T5441 10444-10491 Entity denotes The mutant oligonucleotide PCR primer sequences
T5392 10471-10474 Protein denotes PCR
T5459 10508-10511 Protein denotes Fig
T5475 10544-10548 Protein denotes GLmP
T5400 10633-10646 Protein denotes pGLmP-539mOct
T5454 10634-10638 Protein denotes GLmP
T5471 10679-10694 Protein denotes pGLmP-539mC/EBP
T5474 10680-10684 Protein denotes GLmP
T5436 10696-10707 Protein denotes mPAI2mCEBPa
T5432 10697-10701 Protein denotes PAI2
T5442 10712-10723 Protein denotes mPAI2mCEBPb
T5458 10713-10717 Protein denotes PAI2
T5426 10725-10756 Entity denotes The oligonucleotide PCR primers
T5408 10745-10748 Protein denotes PCR
T5428 10783-10793 Protein denotes pGLmP-539m
T5457 10798-10813 Protein denotes pGLmP-539mAP-1a
T5452 10799-10803 Protein denotes GLmP
T5429 10819-10834 Protein denotes pGLmP-539mAP-1b
T5419 10820-10824 Protein denotes GLmP
T5465 10866-10906 Entity denotes The flanking oligonucleotide PCR primers
T5470 10895-10898 Protein denotes PCR
T5402 11006-11030 Entity denotes Recombinant PCR products
T5418 11018-11021 Protein denotes PCR
T5391 11050-11056 Protein denotes EcoR I
T5460 11061-11066 Protein denotes Xho I
T5473 11086-11096 Protein denotes the EcoR I
T5404 11101-11106 Protein denotes Xho I
T5394 11128-11137 Entity denotes pGLmP-539
T5406 11129-11133 Protein denotes GLmP
T5447 11170-11211 Entity denotes of the wild-type murine SerpinB2 promoter
T5448 11194-11202 Protein denotes SerpinB2
T7595 11300-11310 Protein denotes Luciferase
T6343 11300-11310 Protein denotes Luciferase
T6349 11319-11339 Entity denotes RAW264.7 Macrophages
T6346 11422-11432 Protein denotes luciferase
T6361 11469-11498 Protein denotes the pRL-thymidine kinase (TK)
T6345 11473-11486 Protein denotes pRL-thymidine
T6338 11473-11486 Entity denotes pRL-thymidine
T6352 11477-11486 Entity denotes thymidine
T6363 11495-11497 Protein denotes TK
T6335 11575-11589 Protein denotes a Bio-Rad Gene
T6344 11680-11697 Entity denotes the SV40 promoter
T6350 11807-11815 Entity denotes promoter
T6364 11841-11858 Entity denotes Transfected cells
T6342 11951-11975 Entity denotes two identical cell pools
T6360 11980-12008 Protein denotes incubated 16 hrs in a 5% CO2
T6348 12077-12101 Entity denotes absence of 100 ng/ml LPS
T6357 12103-12113 Protein denotes Luciferase
T6356 12142-12174 Protein denotes a Dual-Luciferase Reporter Assay
T6358 12275-12283 Entity denotes Promoter
T6336 12323-12341 Protein denotes firefly luciferase
T6353 12375-12381 Protein denotes pRL-TK
T6365 12375-12381 Protein denotes pRL-TK
T6341 12379-12381 Protein denotes TK
T6354 12390-12400 Protein denotes luciferase
T6337 12419-12435 Protein denotes cellular protein
T6367 12451-12511 Regulation denotes where co-transfected C/EBP-β or LPS affected pRL-TK activity
T6366 12451-12511 Regulation denotes where co-transfected C/EBP-β or LPS affected pRL-TK activity
T6362 12457-12479 Protein denotes co-transfected C/EBP-β
T6355 12483-12486 Entity denotes LPS
T6351 12496-12502 Protein denotes pRL-TK
T6359 12496-12502 Protein denotes pRL-TK
T6339 12514-12535 Entity denotes Protein concentration
T6347 12569-12595 Protein denotes protein microassay reagent
T6340 12569-12595 Entity denotes protein microassay reagent
T6910 12734-12745 Protein denotes mouse cebpb
T6925 12802-12807 Protein denotes cebpb
T6908 12909-12928 Protein denotes of endogenous C/EBP
T6918 12944-12970 Entity denotes cells of the other species
T6911 13000-13005 Protein denotes CEBPB
T6919 13008-13011 Protein denotes RNA
T6914 13069-13090 Entity denotes lentiviral particles,
T6909 13123-13149 Entity denotes with a mixture of plasmids
T6923 13281-13320 Entity denotes Lipofectamine 2000 reagent (Invitrogen)
T6924 13337-13348 Entity denotes supernatant
T6920 13363-13369 Protein denotes 48 hrs
T6917 13476-13492 Entity denotes The target cells
T6915 13511-13537 Entity denotes the lentiviral supernatant
T6912 13542-13584 Entity denotes 8 µg/ml Polybrene (American Bioanalytical)
T6921 13589-13595 Protein denotes 24 hrs
T6913 13597-13623 Entity denotes The lentiviral supernatant
T6926 13687-13731 Protein denotes 72 hrs to allow for effective gene knockdown
T6916 13717-13721 Protein denotes gene
T6922 13733-13740 Protein denotes C/EBP-β
T7584 13859-13871 Protein denotes MEFs (1×105)
T7592 13913-13923 Protein denotes luciferase
T7594 13961-14003 Protein denotes a β-actin-β-galactosidase reporter plasmid
T7588 13961-14003 Protein denotes a β-actin-β-galactosidase reporter plasmid
T7586 14217-14220 Entity denotes LPS
T7591 14237-14242 Protein denotes 4 hrs
T7577 14299-14306 Protein denotes C/EBP-β
T7576 14310-14363 Protein denotes C/EBP-β phospho-acceptor mutants (T188A, T217A, S64A)
T7578 14344-14357 Protein denotes T188A, T217A,
T7587 14344-14362 Protein denotes T188A, T217A, S64A
T7582 14351-14356 Protein denotes T217A
T7589 14430-14433 Entity denotes DNA
T7585 14436-14459 Protein denotes Luciferase activity was
T7593 14497-14517 Protein denotes β-galactosidase [38]
T7590 14528-14538 Protein denotes Luciferase
T7579 14556-14571 Protein denotes β-Galactosidase
T7583 14556-14596 Protein denotes β-Galactosidase Enzyme Assay System Kits
T7580 14556-14596 Protein denotes β-Galactosidase Enzyme Assay System Kits
T7596 14727-14785 Gene_expression denotes Expression of the C/EBP-β phospho-acceptor mutant proteins
T7575 14738-14785 Protein denotes of the C/EBP-β phospho-acceptor mutant proteins
T7581 14745-14776 Protein denotes C/EBP-β phospho-acceptor mutant
T8044 14890-14921 Entity denotes double-stranded oligonucleotide
T8048 14955-14994 Protein denotes prepared using T4 polynucleotide kinase
T8037 14970-14972 Entity denotes T4
T8031 15006-15010 Entity denotes -ATP
T8056 15012-15038 Entity denotes RAW 264.7 nuclear extracts
T8030 15053-15087 Entity denotes by the detergent lysis method [41]
T8051 15130-15148 Entity denotes 10 mM HEPES pH 7.9
T8035 15159-15187 Entity denotes BSA, 2 mM DTT, 30% glycerol,
T8054 15174-15186 Entity denotes 30% glycerol
T8040 15204-15221 Entity denotes 1 µg poly (dI-dC)
T8053 15231-15247 Entity denotes nuclear extracts
T8055 15269-15272 Protein denotes cpm
T8033 15446-15468 Entity denotes 5% polyacrylamide gels
T8038 15449-15463 Entity denotes polyacrylamide
T8042 15473-15485 Entity denotes 1 acrylamide
T8039 15486-15500 Protein denotes bis-acrylamide
T8034 15486-15500 Entity denotes bis-acrylamide
T8052 15490-15500 Entity denotes acrylamide
T8043 15537-15554 Entity denotes supershift assays
T8046 15556-15572 Entity denotes nuclear extracts
T8050 15578-15641 Protein denotes pre-incubated 2 hrs on ice with 4 µg of specific C/EBP antibody
T8057 15601-15641 Entity denotes ice with 4 µg of specific C/EBP antibody
T8032 15610-15641 Entity denotes 4 µg of specific C/EBP antibody
T8036 15615-15641 Entity denotes of specific C/EBP antibody
T8045 15627-15632 Protein denotes C/EBP
T8041 15643-15653 Entity denotes Antibodies
T8058 15643-15684 Binding denotes Antibodies were purchased from Santa Cruz
T8049 15674-15679 Protein denotes Santa
T8047 15731-15752 Protein denotes anti-C/EBP-δ (sc-151)
T8607 16001-16066 Entity denotes the chromatin with 1% formaldehyde at room temperature for 10 min
T8608 16020-16035 Entity denotes 1% formaldehyde
T8612 16089-16096 Entity denotes glycine
T8616 16128-16133 Entity denotes cells
T8605 16186-16189 Entity denotes ice
T8614 16191-16210 Entity denotes Cells extracts were
T8613 16197-16205 Entity denotes extracts
T8591 16342-16345 Entity denotes ice
T8603 16399-16411 Entity denotes of chromatin
T8615 16474-16498 Entity denotes the following antibodies
T8602 16500-16518 Protein denotes C/EBP-β (sc-150X),
T8609 16500-16535 Protein denotes C/EBP-β (sc-150X), p-C/EBP-β (T217)
T8597 16530-16534 Entity denotes T217
T8611 16609-16626 Protein denotes RNA polymerase II
T8604 16719-16728 Protein denotes Protein G
T8618 16787-16806 Binding denotes the bound chromatin
T8596 16787-16806 Entity denotes the bound chromatin
T8606 16821-16852 Entity denotes ChIP Elution Buffer (Millipore)
T8599 16857-16869 Protein denotes the proteins
T8594 16889-16901 Protein denotes Proteinase K
T8595 16906-16911 Protein denotes 2 hrs
T8592 16921-16928 Entity denotes The DNA
T8610 16966-16969 Protein denotes PCR
T8593 16983-16995 Protein denotes Kit (Qiagen)
T8600 16997-17000 Entity denotes DNA
T8617 17018-17039 Protein denotes semi-quantitative PCR
T8598 17046-17050 Protein denotes qPCR
T8601 17104-17134 Entity denotes the SerpinB2 proximal promoter
T8590 17108-17116 Protein denotes SerpinB2
T8940 17353-17358 Protein denotes ANOVA
T8939 17363-17374 Entity denotes Student’s t
T9270 17450-17467 Protein denotes The SerpinB2 Gene
T9258 17454-17462 Protein denotes SerpinB2
T9278 17492-17495 Entity denotes LPS
T9260 17501-17521 Entity denotes RAW264.7 macrophages
T9259 17538-17542 Entity denotes LPS,
T9262 17543-17586 Protein denotes SerpinB2 mRNA was detectable as early as 30
T9271 17552-17556 Protein denotes mRNA
T9277 17601-17604 Entity denotes LPS
T9263 17643-17659 Protein denotes 24 hrs (Fig. 1A)
T9281 17688-17729 Gene_expression denotes of LPS-inducible SerpinB2 mRNA expression
T9257 17705-17713 Protein denotes SerpinB2
T9261 17705-17718 Protein denotes SerpinB2 mRNA
T9265 17762-17791 Entity denotes murine peritoneal macrophages
T9276 17796-17836 Entity denotes human peripheral blood mononuclear cells
T9272 17848-17859 Entity denotes LPS-induced
T9280 17848-17879 Gene_expression denotes LPS-induced SerpinB2 expression
T9275 17860-17868 Protein denotes SerpinB2
T9282 17894-17927 Positive_regulation denotes an increase in gene transcription
T9279 17906-17927 Transcription denotes in gene transcription
T9269 17909-17913 Protein denotes gene
T9274 17946-17957 Protein denotes of the mRNA
T9273 17980-17988 Protein denotes SerpinB2
T9267 17980-18027 Protein denotes SerpinB2 protein expression was also induced as
T9268 18049-18071 Entity denotes other cell types [31],
T9264 18076-18124 Protein denotes detectable after 8 hrs of LPS treatment (Fig. 1)
T9266 18102-18105 Entity denotes LPS
T22559 18170-18173 Entity denotes LPS
T22556 18187-18195 Protein denotes SerpinB2
T22569 18187-18200 Protein denotes SerpinB2 mRNA
T22558 18205-18212 Protein denotes protein
T22572 18205-18223 Gene_expression denotes protein expression
T22564 18227-18250 Entity denotes murine macrophage cells
T22568 18234-18244 Entity denotes macrophage
T22567 18252-18272 Entity denotes RAW264.7 macrophages
T22565 18319-18328 Entity denotes ng/ml LPS
T22566 18334-18338 Protein denotes qPCR
T22561 18348-18379 Protein denotes of murine SerpinB2 mRNA levels,
T22562 18367-18371 Protein denotes mRNA
T22557 18392-18399 Protein denotes β-actin
T22571 18508-18569 Gene_expression denotes analysis of SerpinB2 protein expression in whole cell lysates
T22560 18520-18528 Protein denotes SerpinB2
T22555 18520-18536 Protein denotes SerpinB2 protein
T22563 18593-18598 Protein denotes GAPDH
T22570 18602-18619 Regulation denotes a loading control
T9999 18622-18652 Entity denotes The SerpinB2 Proximal Promoter
T9995 18622-18652 Protein denotes The SerpinB2 Proximal Promoter
T9980 18661-18664 Entity denotes LPS
T10002 18695-18698 Protein denotes cis
T9990 18740-18797 Entity denotes LPS in the 5′ flanking region of the murine SerpinB2 gene
T10003 18770-18797 Protein denotes of the murine SerpinB2 gene
T10013 18784-18792 Protein denotes SerpinB2
T10008 18799-18810 Entity denotes nucleotides
T9988 18933-18951 Protein denotes firefly luciferase
T9991 18961-18978 Protein denotes gene (pGL3 Basic)
T9987 18967-18971 Protein denotes pGL3
T9977 18967-18977 Protein denotes pGL3 Basic
T9978 19053-19087 Entity denotes sub-confluent RAW264.7 macrophages
T10010 19104-19114 Protein denotes luciferase
T9996 19155-19158 Entity denotes LPS
T10011 19162-19165 Entity denotes PMA
T10000 19183-19194 Entity denotes PMA-induced
T10018 19183-19284 Regulation denotes PMA-induced SerpinB2 gene regulation has been extensively studied in human macrophage cell lines [45]
T9998 19195-19203 Protein denotes SerpinB2
T10007 19195-19208 Protein denotes SerpinB2 gene
T9992 19258-19268 Entity denotes macrophage
T9997 19355-19370 Protein denotes AP-1 responsive
T10016 19428-19436 Protein denotes SerpinB2
T10005 19487-19491 Entity denotes PMA-
T9982 19581-19612 Entity denotes of the murine SerpinB2 promoter
T9981 19595-19603 Protein denotes SerpinB2
T9986 19643-19659 Entity denotes LPS-inducibility
T9979 19787-19820 Entity denotes the LPS-response of the promoter,
T9975 19807-19819 Entity denotes the promoter
T9983 19861-19864 Entity denotes LPS
T10006 19944-19972 Entity denotes the murine SerpinB2 promoter
T9985 19955-19963 Protein denotes SerpinB2
T10009 19976-19979 Entity denotes PMA
T9989 20030-20054 Entity denotes of the SerpinB2 promoter
T10014 20037-20045 Protein denotes SerpinB2
T9994 20087-20090 Entity denotes LPS
T9993 20127-20130 Entity denotes PMA
T10012 20141-20164 Protein denotes the −87 murine SerpinB2
T9984 20165-20183 Entity denotes promoter construct
T10004 20218-20222 Entity denotes PMA,
T9976 20285-20313 Entity denotes the murine SerpinB2 promoter
T10001 20296-20304 Protein denotes SerpinB2
T10017 20317-20320 Entity denotes PMA
T10015 20344-20354 Entity denotes nucleotide
T23056 20422-20426 Protein denotes gene
T23091 20439-20442 Entity denotes LPS
T23071 20473-20501 Entity denotes the murine SerpinB2 promoter
T23081 20484-20492 Protein denotes SerpinB2
T23083 20546-20599 Protein denotes SerpinB2 promoter and 5′ deletion luciferase reporter
T23088 20685-20713 Protein denotes the luciferase reporter gene
T23073 20689-20699 Protein denotes luciferase
T23069 20752-20770 Protein denotes restriction enzyme
T23084 20752-20776 Entity denotes restriction enzyme sites
T23075 20785-20821 Entity denotes specific oligonucleotide PCR primers
T23082 20810-20813 Protein denotes PCR
T23055 20848-20910 Entity denotes the most 5′ nucleotide of murine SerpinB2 5′ flanking sequence
T23076 20881-20889 Protein denotes SerpinB2
T23074 20916-20937 Entity denotes RAW 264.7 macrophages
T23070 20986-21021 Protein denotes murine SerpinB2 promoter-luciferase
T23061 20986-21021 Entity denotes murine SerpinB2 promoter-luciferase
T23064 20993-21001 Protein denotes SerpinB2
T23062 21064-21069 Entity denotes Cells
T23080 21082-21126 Entity denotes left untreated or treated with 100 ng/ml LPS
T23066 21133-21153 Entity denotes ng/ml PMA for 16 hrs
T23058 21147-21153 Protein denotes 16 hrs
T23059 21177-21187 Protein denotes luciferase
T23068 21197-21201 Protein denotes gene
T23063 21308-21311 Entity denotes DNA
T23086 21363-21371 Protein denotes SerpinB2
T23087 21435-21450 Protein denotes murine SerpinB2
T23065 21487-21497 Entity denotes nucleotide
T23060 21526-21551 Entity denotes by the same colored boxes
T23054 21667-21671 Protein denotes ID4 
T23078 21667-21683 Protein denotes ID4 =  ID4 short
T23079 21720-21723 Protein denotes L1 
T23090 21720-21728 Protein denotes L1 =  L1
T23089 21771-21774 Entity denotes L2 
T23085 21777-21779 Entity denotes L2
T23057 21786-21790 Protein denotes MIR 
T23077 21792-21795 Protein denotes MIR
T23053 21850-21852 Entity denotes n 
T23092 21859-21864 Entity denotes tetra
T23067 21859-21874 Entity denotes tetranucleotide
T23072 21883-21887 Entity denotes tis 
T10952 21964-21998 Entity denotes Murine SerpinB2 Proximal Promoters
T10936 21971-21979 Protein denotes SerpinB2
T10971 22011-22031 Protein denotes potential cis-acting
T10943 22077-22101 Protein denotes the murine SerpinB2 gene
T10972 22088-22096 Protein denotes SerpinB2
T10960 22159-22167 Protein denotes SerpinB2
T10939 22248-22292 Entity denotes potential transcription factor binding sites
T10976 22329-22376 Regulation denotes the regulation of SerpinB2 gene expression [52]
T10977 22344-22376 Gene_expression denotes of SerpinB2 gene expression [52]
T10962 22347-22355 Protein denotes SerpinB2
T10940 22502-22518 Entity denotes murine promoters
T10967 22530-22563 Entity denotes The proximal promoter (Region E),
T10958 22593-22596 Entity denotes LPS
T10942 22748-22784 Entity denotes the human SerpinB2 proximal promoter
T10959 22758-22766 Protein denotes SerpinB2
T10963 22802-22839 Entity denotes the murine SerpinB2 promoter (Fig. 3)
T10941 22813-22821 Protein denotes SerpinB2
T10973 22917-22978 Entity denotes the transcription initiation site, similar to the position of
T10944 22979-23023 Entity denotes the TATA box of the human SERPINB2 gene [53]
T10938 22992-23023 Protein denotes of the human SERPINB2 gene [53]
T10974 23005-23013 Protein denotes SERPINB2
T10970 23065-23080 Protein denotes protein (C/EBP)
T10969 23074-23079 Protein denotes C/EBP
T10955 23111-23151 Protein denotes two potential activator protein 1 (AP-1)
T10937 23146-23150 Protein denotes AP-1
T10956 23236-23239 Entity denotes AMP
T10966 23258-23261 Protein denotes CRE
T10954 23288-23310 Entity denotes Both of the AP-1 sites
T10968 23293-23310 Entity denotes of the AP-1 sites
T10949 23300-23304 Protein denotes AP-1
T10951 23360-23388 Entity denotes the human SERPINB2 promoter,
T10946 23370-23378 Protein denotes SERPINB2
T10947 23393-23400 Protein denotes the CRE
T10935 23428-23460 Entity denotes a single central nucleotide [37]
T10948 23480-23497 Entity denotes E box (−538/−533)
T10975 23510-23564 Binding denotes potential binding sites for PU.1 (−412/−407) and Oct-1
T10957 23510-23564 Entity denotes potential binding sites for PU.1 (−412/−407) and Oct-1
T10964 23538-23554 Protein denotes PU.1 (−412/−407)
T10945 23559-23564 Protein denotes Oct-1
T10953 23605-23626 Entity denotes the proximal promoter
T10961 23635-23638 Protein denotes Fig
T10934 23645-23678 Entity denotes Further upstream, a retinoic acid
T10965 23778-23782 Entity denotes site
T10950 23799-23806 Entity denotes Fig. S2
T23609 23942-23945 Entity denotes LPS
T23608 23964-23995 Entity denotes of the murine SerpinB2 promoter
T23624 23978-23986 Protein denotes SerpinB2
T23623 24021-24031 Entity denotes nucleotide
T23610 24061-24079 Entity denotes Clustal W software
T23614 24081-24084 Protein denotes Cis
T23620 24133-24158 Entity denotes murine SerpinB2 promoters
T23613 24140-24148 Protein denotes SerpinB2
T23617 24182-24187 Protein denotes AP-1 
T23628 24182-24207 Entity denotes AP-1 =  activator protein
T23619 24182-24207 Protein denotes AP-1 =  activator protein
T23611 24211-24217 Protein denotes C/EBP 
T23612 24252-24256 Protein denotes CRE 
T23616 24252-24326 Protein denotes CRE = cAMP response element; Oct1 =  octamer transcription factor 1/POU2F1
T23621 24258-24262 Protein denotes cAMP
T23627 24289-24326 Protein denotes octamer transcription factor 1/POU2F1
T23626 24289-24326 Protein denotes octamer transcription factor 1/POU2F1
T23618 24320-24326 Protein denotes POU2F1
T23622 24328-24333 Protein denotes PU.1 
T23629 24328-24364 Protein denotes PU.1 =  purine box binding protein 1
T23625 24366-24414 Entity denotes The putative transcription initiation site (tis)
T23615 24432-24438 Entity denotes exon 1
T12008 24559-24564 Protein denotes C/EBP
T12043 24559-24688 Regulation denotes C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription
T12042 24559-24688 Regulation denotes C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription
T12041 24559-24688 Regulation denotes C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription
T12007 24566-24569 Protein denotes CRE
T12031 24574-24634 Entity denotes Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter
T12003 24578-24582 Protein denotes AP-1
T12025 24592-24634 Entity denotes the Murine SerpinB2 Gene Proximal Promoter
T11986 24592-24634 Protein denotes the Murine SerpinB2 Gene Proximal Promoter
T11998 24603-24611 Protein denotes SerpinB2
T12040 24815-24925 Regulation denotes sites for transcription factors previously reported to mediate LPS-inducible transcription in other genes [57]
T11984 24815-24925 Entity denotes sites for transcription factors previously reported to mediate LPS-inducible transcription in other genes [57]
T12011 24909-24925 Protein denotes other genes [57]
T11993 24943-24953 Entity denotes nucleotide
T12021 25019-25028 Protein denotes the pGLmP
T11989 25040-25082 Protein denotes SerpinB2 promoter-luciferase reporter gene
T12000 25094-25097 Protein denotes Fig
T12035 25134-25168 Entity denotes of the consensus E box (−538/−533)
T11991 25134-25168 Entity denotes of the consensus E box (−538/−533)
T11999 25170-25186 Protein denotes PU.1 (−412/−407)
T12018 25203-25220 Protein denotes Oct-1 (−296/−288)
T11996 25221-25225 Entity denotes site
T12010 25255-25263 Entity denotes promoter
T11987 25296-25313 Entity denotes of the C/EBP site
T11992 25303-25308 Protein denotes C/EBP
T12029 25348-25356 Entity denotes promoter
T12036 25402-25437 Entity denotes the −189 SerpinB2 promoter deletion
T12038 25411-25419 Protein denotes SerpinB2
T12044 25456-25548 Gene_expression denotes have also recently implicated this C/EBP site in LPS-induced activation of the SerpinB2 gene
T12001 25486-25501 Entity denotes this C/EBP site
T12024 25491-25496 Protein denotes C/EBP
T12023 25505-25516 Entity denotes LPS-induced
T12039 25505-25548 Positive_regulation denotes LPS-induced activation of the SerpinB2 gene
T12013 25528-25548 Protein denotes of the SerpinB2 gene
T12034 25535-25543 Protein denotes SerpinB2
T23983 25650-25704 Entity denotes the LPS-responsiveness of the murine SerpinB2 promoter
T23991 25673-25704 Entity denotes of the murine SerpinB2 promoter
T23989 25687-25695 Protein denotes SerpinB2
T23997 25758-25789 Entity denotes of the murine SerpinB2 promoter
T23984 25772-25780 Protein denotes SerpinB2
T23987 25821-25824 Protein denotes cis
T23993 25867-25872 Entity denotes boxes
T23990 25973-26067 Entity denotes of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays
T23988 25973-26067 Entity denotes of murine SerpinB2 proximal promoter-specific primers, 338/−315 and −5/+19 used in ChIP assays
T23996 25983-25991 Protein denotes SerpinB2
T23994 26056-26067 Entity denotes ChIP assays
T23986 26087-26108 Entity denotes RAW 264.7 macrophages
T23981 26157-26212 Protein denotes murine SerpinB2 promoter-luciferase reporter constructs
T23985 26259-26279 Entity denotes ng/ml LPS for 16 hrs
T23992 26273-26279 Protein denotes 16 hrs
T23995 26307-26317 Protein denotes luciferase
T23982 26337-26340 Entity denotes LPS
T12027 26465-26472 Protein denotes the CRE
T11995 26477-26491 Entity denotes two AP-1 sites
T12009 26481-26485 Protein denotes AP-1
T12002 26495-26523 Entity denotes the murine SerpinB2 promoter
T12005 26506-26514 Protein denotes SerpinB2
T11994 26559-26620 Entity denotes in the PMA-responsiveness of the human SERPINB2 promoter [37]
T11990 26585-26620 Entity denotes of the human SERPINB2 promoter [37]
T12032 26598-26606 Protein denotes SERPINB2
T12022 26622-26633 Entity denotes these sites
T11997 26655-26665 Entity denotes nucleotide
T12028 26728-26731 Entity denotes LPS
T12012 26744-26772 Entity denotes the murine SerpinB2 promoter
T12014 26755-26763 Protein denotes SerpinB2
T11985 26786-26789 Protein denotes Fig
T12004 26804-26814 Protein denotes of the CRE
T12015 26831-26872 Entity denotes either of the two AP-1 sites at −106/−100
T11988 26838-26872 Entity denotes of the two AP-1 sites at −106/−100
T12033 26849-26853 Protein denotes AP-1
T12037 26936-26946 Protein denotes luciferase
T12020 26961-26989 Entity denotes the murine SerpinB2 promoter
T12019 26972-26980 Protein denotes SerpinB2
T12006 27016-27021 Protein denotes C/EBP
T12026 27042-27049 Protein denotes the CRE
T12017 27059-27063 Protein denotes AP-1
T12030 27101-27104 Entity denotes LPS
T11983 27134-27164 Entity denotes the SerpinB2 proximal promoter
T12016 27138-27146 Protein denotes SerpinB2
T12791 27167-27184 Entity denotes The C/EBP Element
T12789 27171-27176 Protein denotes C/EBP
T12765 27194-27253 Entity denotes by an LPS-induced Nuclear Factor from RAW 264.7 Macrophages
T12794 27200-27203 Entity denotes LPS
T12772 27232-27253 Entity denotes RAW 264.7 Macrophages
T12784 27293-27298 Protein denotes C/EBP
T12786 27389-27405 Entity denotes nuclear extracts
T12790 27411-27458 Entity denotes untreated and LPS-treated RAW 264.7 macrophages
T12766 27425-27436 Entity denotes LPS-treated
T12796 27460-27507 Entity denotes Three different double stranded oligonucleotide
T12788 27552-27587 Protein denotes the putative SerpinB2 C/EBP element
T12774 27565-27573 Protein denotes SerpinB2
T12763 27614-27622 Protein denotes SerpinB2
T12795 27642-27681 Protein denotes the same mutation as in pGLmP-539mC/EBP
T12777 27667-27671 Protein denotes GLmP
T12787 27690-27714 Entity denotes the rat albumin promoter
T12781 27698-27705 Protein denotes albumin
T12793 27733-27736 Protein denotes DEI
T12799 27756-27790 Binding denotes a high affinity C/EBP binding site
T12770 27756-27790 Entity denotes a high affinity C/EBP binding site
T12785 27772-27777 Protein denotes C/EBP
T12773 27841-27870 Entity denotes DNA-nuclear protein complexes
T12771 27921-27923 Entity denotes II
T12769 27940-27949 Entity denotes complexes
T12762 28025-28032 Entity denotes complex
T12783 28045-28051 Entity denotes by LPS
T12767 28053-28078 Entity denotes The LPS-inducible complex
T12792 28113-28118 Protein denotes C/EBP
T12782 28206-28222 Entity denotes oligonucleotide,
T12798 28298-28357 Binding denotes of a known C/EBP binding site from the rat albumin promoter
T12780 28298-28357 Entity denotes of a known C/EBP binding site from the rat albumin promoter
T12759 28309-28314 Protein denotes C/EBP
T12764 28333-28357 Entity denotes the rat albumin promoter
T12778 28341-28348 Protein denotes albumin
T12775 28395-28422 Entity denotes the mutated oligonucleotide
T12797 28449-28638 Binding denotes Together these data indicate that the putative SerpinB2 C/EBP site at −203/−192 binds a LPS-inducible complex that is likely to contain a member of the C/EBP family of transcription factors
T12779 28483-28515 Entity denotes the putative SerpinB2 C/EBP site
T12768 28483-28515 Protein denotes the putative SerpinB2 C/EBP site
T12776 28496-28504 Protein denotes SerpinB2
T12760 28535-28638 Entity denotes a LPS-inducible complex that is likely to contain a member of the C/EBP family of transcription factors
T12761 28601-28606 Protein denotes C/EBP
T24313 28725-28768 Entity denotes the murine SerpinB2 proximal promoter C/EBP
T24331 28736-28744 Protein denotes SerpinB2
T24316 28765-28768 Protein denotes EBP
T24308 28769-28773 Entity denotes site
T24322 28783-28790 Protein denotes C/EBP-β
T24309 28806-28822 Entity denotes nuclear extracts
T24325 28847-28864 Entity denotes 10 hr LPS treated
T24310 28866-28869 Entity denotes LPS
T24332 28976-28984 Protein denotes SerpinB2
T24323 28976-28990 Protein denotes SerpinB2 C/EBP
T24311 29004-29016 Protein denotes mutant C/EBP
T24318 29018-29023 Protein denotes C/EBP
T24328 29018-29028 Entity denotes C/EBP site
T24315 29037-29098 Entity denotes the rat albumin promoter DEI region C/EBP (rat albumin C/EBP)
T24312 29037-29098 Protein denotes the rat albumin promoter DEI region C/EBP (rat albumin C/EBP)
T24327 29045-29052 Protein denotes albumin
T24307 29062-29065 Protein denotes DEI
T24319 29080-29097 Protein denotes rat albumin C/EBP
T24320 29084-29091 Protein denotes albumin
T24314 29148-29206 Entity denotes the radiolabelled murine SerpinB2 promoter −212/−185 probe
T24326 29173-29181 Protein denotes SerpinB2
T24324 29257-29292 Entity denotes stranded oligonucleotides described
T24330 29328-29356 Entity denotes of the DNA-protein complexes
T24317 29462-29485 Protein denotes specific C/EBP antibody
T24321 29471-29476 Protein denotes C/EBP
T24329 29487-29512 Entity denotes The LPS-inducible complex
T13587 29546-29553 Protein denotes C/EBP-β
T13572 29559-29570 Entity denotes LPS-induced
T13591 29604-29609 Protein denotes C/EBP
T13565 29618-29651 Entity denotes of the SerpinB2 Proximal Promoter
T13586 29625-29633 Protein denotes SerpinB2
T13570 29656-29661 Protein denotes C/EBP
T13568 29678-29685 Entity denotes leucine
T13576 29819-29850 Protein denotes the C/EBP transcription factors
T13585 29823-29828 Protein denotes C/EBP
T13575 29949-29956 Protein denotes C/EBP-α
T13590 29958-29965 Protein denotes C/EBP-β
T13579 29967-29974 Protein denotes C/EBP-δ
T13580 29979-29986 Protein denotes C/EBP-ε
T13563 30003-30016 Entity denotes myeloid cells
T13557 30045-30122 Entity denotes differentiating myeloid cells depending on the extracellular environment [61]
T13564 30092-30105 Entity denotes extracellular
T13583 30143-30148 Protein denotes C/EBP
T13571 30143-30157 Protein denotes C/EBP proteins
T13569 30189-30230 Entity denotes of the different nucleo-protein complexes
T13559 30189-30230 Protein denotes of the different nucleo-protein complexes
T13578 30252-30278 Entity denotes the LPS-inducible complex,
T13582 30315-30343 Protein denotes the nucleo-protein complexes
T13567 30315-30343 Entity denotes the nucleo-protein complexes
T13562 30349-30359 Entity denotes antibodies
T13588 30373-30380 Protein denotes C/EBP-α
T13558 30382-30389 Protein denotes C/EBP-β
T13589 30391-30398 Protein denotes C/EBP-δ
T13592 30403-30410 Protein denotes C/EBP-ε
T13584 30417-30425 Protein denotes antibody
T13574 30474-30499 Protein denotes of the respective protein
T13555 30527-30556 Protein denotes antibody with nuclear extract
T13573 30541-30556 Entity denotes nuclear extract
T13566 30606-30621 Entity denotes Only antibodies
T13556 30630-30637 Protein denotes C/EBP-β
T13581 30662-30700 Entity denotes of the LPS-inducible complex (Fig. 5C)
T13560 30742-30753 Entity denotes LPS-induced
T13577 30771-30776 Protein denotes C/EBP
T13561 30806-30813 Protein denotes C/EBP-β
T14517 30816-30823 Protein denotes C/EBP-β
T14534 30855-30866 Entity denotes LPS-induced
T14535 30855-30875 Protein denotes LPS-induced SerpinB2
T14500 30876-30880 Protein denotes mRNA
T14553 30876-30936 Gene_expression denotes mRNA Expression in MEFs and Inflammatory Primary Macrophages
T14552 30876-30936 Transcription denotes mRNA Expression in MEFs and Inflammatory Primary Macrophages
T14533 30895-30899 Protein denotes MEFs
T14528 30904-30936 Entity denotes Inflammatory Primary Macrophages
T14522 30967-30977 Protein denotes of C/EBP-β
T14509 30981-31000 Protein denotes endogenous SerpinB2
T14505 31001-31005 Protein denotes mRNA
T14551 31001-31036 Gene_expression denotes mRNA expression in response to LPS,
T14550 31001-31036 Transcription denotes mRNA expression in response to LPS,
T14515 31049-31073 Protein denotes C/EBP-β-null (Cebpb −/−)
T14508 31078-31104 Protein denotes wild-type MEFs (Cebpb+/+),
T14524 31149-31167 Protein denotes endogenous C/EBP-β
T14520 31169-31183 Protein denotes Wild-type MEFs
T14525 31206-31225 Protein denotes endogenous SerpinB2
T14530 31242-31252 Protein denotes of C/EBP-β
T14548 31264-31299 Gene_expression denotes endogenous SerpinB2 mRNA expression
T14514 31275-31283 Protein denotes SerpinB2
T14531 31275-31288 Protein denotes SerpinB2 mRNA
T14527 31301-31304 Entity denotes LPS
T14541 31301-31373 Positive_regulation denotes LPS stimulated an increase in SerpinB2 mRNA expression in wild-type MEFs
T14540 31316-31373 Positive_regulation denotes an increase in SerpinB2 mRNA expression in wild-type MEFs
T14545 31328-31355 Gene_expression denotes in SerpinB2 mRNA expression
T14504 31331-31339 Protein denotes SerpinB2
T14501 31331-31344 Protein denotes SerpinB2 mRNA
T14507 31359-31373 Protein denotes wild-type MEFs
T14532 31375-31378 Protein denotes Fig
T14547 31385-31469 Negative_regulation denotes whereas LPS-stimulated SerpinB2 mRNA expression was significantly dampened in Cebpb−
T14546 31385-31469 Negative_regulation denotes whereas LPS-stimulated SerpinB2 mRNA expression was significantly dampened in Cebpb−
T14513 31393-31396 Entity denotes LPS
T14539 31393-31416 Positive_regulation denotes LPS-stimulated SerpinB2
T14529 31408-31416 Protein denotes SerpinB2
T14506 31417-31421 Protein denotes mRNA
T14543 31417-31432 Transcription denotes mRNA expression
T14542 31417-31432 Gene_expression denotes mRNA expression
T14521 31463-31469 Protein denotes Cebpb−
T14502 31472-31476 Protein denotes MEFs
T14503 31554-31602 Entity denotes thioglycollate-elicited inflammatory macrophages
T14519 31612-31619 Protein denotes C/EBP-β
T14544 31612-31630 Gene_expression denotes C/EBP-β expression
T14523 31725-31730 Protein denotes MEFs,
T14516 31753-31764 Entity denotes LPS-induced
T14538 31753-31789 Gene_expression denotes LPS-induced SerpinB2 mRNA expression
T14537 31753-31863 Negative_regulation denotes LPS-induced SerpinB2 mRNA expression was significantly decreased in C/EBP-β-deficient inflammatory macrophages
T14497 31765-31773 Protein denotes SerpinB2
T14510 31765-31778 Protein denotes SerpinB2 mRNA
T14511 31821-31828 Protein denotes C/EBP-β
T14526 31829-31863 Entity denotes deficient inflammatory macrophages
T14512 31865-31868 Protein denotes Fig
T14518 31903-31910 Protein denotes C/EBP-β
T14536 31923-32009 Regulation denotes for mediating constitutive and LPS-inducible transcription of endogenous SerpinB2 mRNA
T14549 31937-32009 Transcription denotes constitutive and LPS-inducible transcription of endogenous SerpinB2 mRNA
T14498 31982-32009 Protein denotes of endogenous SerpinB2 mRNA
T14499 31996-32004 Protein denotes SerpinB2
T25028 32055-32062 Protein denotes C/EBP-β
T25032 32076-32133 Gene_expression denotes for constitutive and LPS-induced SerpinB2 mRNA expression
T25018 32097-32108 Entity denotes LPS-induced
T25020 32109-32117 Protein denotes SerpinB2
T25021 32109-32122 Protein denotes SerpinB2 mRNA
T25015 32150-32158 Protein denotes SerpinB2
T25003 32150-32163 Protein denotes SerpinB2 mRNA
T25031 32150-32174 Gene_expression denotes SerpinB2 mRNA expression
T25035 32150-32199 Negative_regulation denotes SerpinB2 mRNA expression is abrogated in Cebpb−/−
T25001 32200-32204 Protein denotes MEFs
T25023 32214-32230 Protein denotes to Cebpb+/+ MEFs
T25005 32259-32265 Entity denotes of LPS
T25022 32267-32271 Protein denotes qPCR
T25026 32281-32299 Protein denotes of murine SerpinB2
T25011 32300-32304 Protein denotes mRNA
T25034 32300-32337 Gene_expression denotes mRNA expression in untreated Cebpb+/+
T25033 32300-32337 Transcription denotes mRNA expression in untreated Cebpb+/+
T25008 32342-32348 Protein denotes Cebpb−
T25000 32351-32356 Protein denotes MEFs,
T24998 32383-32386 Entity denotes LPS
T25029 32439-32447 Protein denotes SerpinB2
T25030 32475-32482 Protein denotes C/EBP-β
T24999 32483-32517 Entity denotes deficient inflammatory macrophages
T25007 32519-32575 Entity denotes Thioglycollate-elicited peritoneal macrophages (TG macs)
T25014 32567-32569 Protein denotes TG
T25006 32567-32574 Protein denotes TG macs
T25012 32646-32651 Protein denotes CEBPB
T25013 32730-32735 Protein denotes Cebpb
T25019 32751-32784 Entity denotes Lentiviral transduced macrophages
T25025 32806-32809 Entity denotes LPS
T25024 32826-32831 Protein denotes 4 hrs
T25017 32887-32908 Protein denotes of endogenous C/EBP-β
T25002 32941-32946 Protein denotes Cebpb
T25009 32967-32972 Protein denotes CEBPB
T25010 32987-32991 Protein denotes qPCR
T25036 32987-33087 Gene_expression denotes qPCR analysis of murine SerpinB2 mRNA expression in the lentiviral transduced peritoneal macrophages
T25027 33011-33019 Protein denotes SerpinB2
T25016 33011-33024 Protein denotes SerpinB2 mRNA
T25004 33039-33087 Entity denotes the lentiviral transduced peritoneal macrophages
T15283 33226-33233 Protein denotes C/EBP-β
T15326 33226-33268 Binding denotes C/EBP-β Binds the Murine SerpinB2 Proximal
T15294 33240-33268 Protein denotes the Murine SerpinB2 Proximal
T15304 33269-33312 Entity denotes Promoter in vivo in an LPS-inducible Manner
T15327 33351-33373 Binding denotes of C/EBP-β recruitment
T15270 33354-33361 Protein denotes C/EBP-β
T15305 33377-33405 Entity denotes the murine SerpinB2 promoter
T15311 33388-33396 Protein denotes SerpinB2
T15275 33421-33472 Entity denotes LPS in vivo by chromatin immunoprecipitation (ChIP)
T15312 33436-33445 Entity denotes chromatin
T15282 33511-33514 Entity denotes LPS
T15273 33519-33530 Protein denotes up to 8 hrs
T15295 33532-33549 Entity denotes soluble chromatin
T15289 33573-33588 Entity denotes with antibodies
T15269 33597-33618 Protein denotes DNA binding proteins,
T15281 33623-33639 Entity denotes the enriched DNA
T15272 33680-33684 Protein denotes qPCR
T15274 33691-33699 Protein denotes SerpinB2
T15286 33700-33726 Entity denotes proximal promoter specific
T15318 33785-33792 Protein denotes C/EBP-β
T15310 33822-33843 Entity denotes the SerpinB2 promoter
T15317 33826-33834 Protein denotes SerpinB2
T15319 33879-33896 Entity denotes with the promoter
T15278 33913-33924 Entity denotes macrophages
T15280 33965-33968 Entity denotes LPS
T15292 34027-34032 Protein denotes 8 hrs
T15279 34034-34037 Protein denotes Fig
T15298 34060-34067 Protein denotes C/EBP-β
T15321 34060-34083 Phosphorylation denotes C/EBP-β phosphorylation
T15320 34123-34154 Positive_regulation denotes transactivate target genes [38]
T15299 34137-34154 Protein denotes target genes [38]
T15302 34199-34288 Entity denotes the SerpinB2 proximal promoter of the T217 phosphorylated C/EBP-β isoform (p-C/EBP-βT217)
T15316 34203-34211 Protein denotes SerpinB2
T15300 34233-34288 Entity denotes the T217 phosphorylated C/EBP-β isoform (p-C/EBP-βT217)
T15309 34257-34264 Protein denotes C/EBP-β
T15288 34274-34287 Protein denotes p-C/EBP-βT217
T15290 34316-34339 Entity denotes with cell survival [65]
T15276 34341-34354 Protein denotes p-C/EBP-βT217
T15325 34341-34413 Binding denotes p-C/EBP-βT217 was constitutively bound to the SerpinB2 proximal promoter
T15301 34380-34413 Entity denotes to the SerpinB2 proximal promoter
T15307 34387-34395 Protein denotes SerpinB2
T15284 34445-34448 Entity denotes LPS
T15296 34462-34465 Protein denotes Fig
T15287 34492-34500 Protein denotes C/EBP-β,
T15324 34501-34564 Binding denotes the binding affinity of p-C/EBP-βT217 for the SerpinB2 proximal
T15323 34501-34564 Binding denotes the binding affinity of p-C/EBP-βT217 for the SerpinB2 proximal
T15303 34522-34538 Protein denotes of p-C/EBP-βT217
T15313 34539-34564 Protein denotes for the SerpinB2 proximal
T15291 34565-34639 Entity denotes promoter diminished with LPS stimulation at later timepoints (4 and 8 hrs)
T15306 34590-34593 Entity denotes LPS
T15314 34633-34638 Protein denotes 8 hrs
T15285 34640-34643 Protein denotes Fig
T15308 34697-34704 Protein denotes C/EBP-β
T15277 34709-34722 Protein denotes p-C/EBP-βT217
T15322 34709-34734 Binding denotes p-C/EBP-βT217 recruitment
T15315 34754-34773 Entity denotes T217-phosphorylated
T15328 34754-34781 Phosphorylation denotes T217-phosphorylated C/EBP-β
T15271 34754-34781 Protein denotes T217-phosphorylated C/EBP-β
T15293 34838-34859 Entity denotes the SerpinB2 promoter
T15297 34842-34850 Protein denotes SerpinB2
T25724 34952-34959 Protein denotes C/EBP-β
T25720 34979-35015 Entity denotes the murine SerpinB2 promoter in vivo
T25733 34990-34998 Protein denotes SerpinB2
T25709 35051-35072 Protein denotes the SerpinB2 proximal
T25714 35073-35089 Entity denotes promoter in vivo
T25717 35108-35117 Entity denotes chromatin
T25705 35152-35172 Entity denotes RAW264.7 macrophages
T25723 35213-35219 Entity denotes of LPS
T25738 35248-35257 Entity denotes chromatin
T25735 35294-35304 Entity denotes antibodies
T25721 35313-35320 Protein denotes C/EBP-β
T25711 35324-35333 Protein denotes p-C/EBP-β
T25719 35335-35339 Entity denotes T217
T25704 35342-35359 Entity denotes Soluble chromatin
T25726 35396-35411 Entity denotes with antibodies
T25718 35420-35446 Protein denotes C/EBP-β, p-C/EBP-β (T217),
T25729 35420-35464 Protein denotes C/EBP-β, p-C/EBP-β (T217), RNA Polymerase II
T25713 35429-35445 Protein denotes p-C/EBP-β (T217)
T25707 35440-35444 Entity denotes T217
T25732 35487-35489 Protein denotes Ig
T25710 35492-35496 Protein denotes rIgG
T25725 35519-35522 Protein denotes PCR
T25708 35543-35554 Entity denotes ChIP assays
T25716 35568-35576 Protein denotes SerpinB2
T25739 35586-35603 Entity denotes promoter-specific
T25730 35681-35711 Protein denotes the SerpinB2 promoter suggests
T25741 35681-35758 Transcription denotes the SerpinB2 promoter suggests active transcription following LPS stimulation
T25734 35694-35702 Entity denotes promoter
T25737 35743-35746 Entity denotes LPS
T25722 35879-35882 Protein denotes PCR
T25736 35892-35939 Entity denotes of chromatin immunoprecipitated with antibodies
T25727 35929-35939 Entity denotes antibodies
T25712 35948-35955 Protein denotes C/EBP-β
T25706 35957-35973 Protein denotes p-C/EBP-β (T217)
T25715 35968-35972 Entity denotes T217
T25740 35979-35995 Regulation denotes the rIgG control
T25728 35983-35987 Protein denotes rIgG
T25731 36034-36038 Protein denotes rIgG
T16094 36072-36079 Protein denotes C/EBP-β
T16102 36072-36145 Positive_regulation denotes C/EBP-β Promotes LPS-inducible Murine SerpinB2 Proximal Promoter Activity
T16073 36110-36118 Protein denotes SerpinB2
T16093 36128-36136 Entity denotes Promoter
T16105 36146-36252 Binding denotes Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo
T16097 36152-36159 Protein denotes C/EBP-β
T16075 36166-36199 Entity denotes to the SerpinB2 proximal promoter
T16078 36173-36181 Protein denotes SerpinB2
T16100 36299-36306 Protein denotes C/EBP-β
T16088 36362-36383 Entity denotes the SerpinB2 promoter
T16082 36366-36374 Protein denotes SerpinB2
T16096 36387-36392 Entity denotes cells
T16074 36408-36411 Entity denotes LPS
T16080 36425-36446 Protein denotes of endogenous C/EBP-β
T16103 36447-36497 Regulation denotes to direct transcription from the SerpinB2 proximal
T16098 36476-36497 Protein denotes the SerpinB2 proximal
T16092 36498-36506 Entity denotes promoter
T16091 36544-36548 Protein denotes GLmP
T16072 36560-36588 Protein denotes SerpinB2 luciferase reporter
T16099 36604-36609 Protein denotes Cebpb
T16085 36617-36623 Protein denotes Cebpb−
T16101 36626-36630 Protein denotes MEFs
T16087 36646-36660 Entity denotes LPS-stimulated
T16104 36646-36687 Positive_regulation denotes LPS-stimulated SerpinB2 promoter activity
T16086 36661-36669 Protein denotes SerpinB2
T16077 36661-36678 Entity denotes SerpinB2 promoter
T16090 36728-36732 Protein denotes MEFs
T16076 36750-36756 Protein denotes Cebpb−
T16083 36759-36763 Protein denotes MEFs
T16089 36765-36768 Protein denotes Fig
T16084 36786-36809 Protein denotes that endogenous C/EBP-β
T16079 36826-36837 Entity denotes LPS-induced
T16081 36826-36873 Protein denotes LPS-induced SerpinB2 proximal promoter activity
T16095 36856-36864 Entity denotes promoter
T26703 36919-36926 Protein denotes C/EBP-β
T26737 36944-36952 Protein denotes SerpinB2
T26728 36944-36970 Entity denotes SerpinB2 proximal promoter
T26727 36985-37015 Entity denotes The SerpinB2 proximal promoter
T26699 36989-36997 Protein denotes SerpinB2
T26721 37046-37060 Entity denotes LPS-stimulated
T26746 37046-37074 Positive_regulation denotes LPS-stimulated Cebpb+/+ MEFs
T26696 37046-37074 Protein denotes LPS-stimulated Cebpb+/+ MEFs
T26735 37086-37091 Protein denotes Cebpb
T26726 37095-37099 Protein denotes MEFs
T26722 37101-37139 Protein denotes Murine SerpinB2 gene promoter activity
T26738 37108-37116 Protein denotes SerpinB2
T26712 37122-37130 Entity denotes promoter
T26704 37165-37171 Protein denotes Cebpb−
T26744 37174-37275 Gene_expression denotes MEFs expressing the pGLmP-539 SerpinB2 promoter-luciferase reporter in the presence or absence of LPS
T26732 37174-37275 Protein denotes MEFs expressing the pGLmP-539 SerpinB2 promoter-luciferase reporter in the presence or absence of LPS
T26730 37190-37241 Protein denotes the pGLmP-539 SerpinB2 promoter-luciferase reporter
T26708 37195-37199 Protein denotes GLmP
T26707 37269-37275 Entity denotes of LPS
T26725 37289-37294 Entity denotes Cells
T26729 37320-37371 Protein denotes the pGLmP-539 SerpinB2 promoter-luciferase reporter
T26723 37325-37329 Protein denotes GLmP
T26740 37376-37400 Protein denotes β-galactosidase reporter
T26719 37415-37425 Protein denotes luciferase
T26724 37446-37461 Protein denotes β-galactosidase
T26739 37476-37483 Protein denotes C/EBP-β
T26745 37476-37523 Gene_expression denotes C/EBP-β gene schematic depicting gene structure
T26714 37476-37523 Protein denotes C/EBP-β gene schematic depicting gene structure
T26700 37509-37513 Protein denotes gene
T26702 37528-37550 Entity denotes phospho-acceptor sites
T26694 37536-37544 Entity denotes acceptor
T26742 37556-37658 Regulation denotes Phosphorylation of C/EBP-β at Serine 64 negatively regulates LPS-stimulated SerpinB2 promoter activity
T26716 37572-37582 Protein denotes of C/EBP-β
T26709 37586-37595 Entity denotes Serine 64
T26706 37617-37631 Entity denotes LPS-stimulated
T26743 37617-37658 Positive_regulation denotes LPS-stimulated SerpinB2 promoter activity
T26713 37632-37640 Protein denotes SerpinB2
T26718 37632-37649 Entity denotes SerpinB2 promoter
T26705 37660-37666 Protein denotes Cebpb−
T26733 37669-37672 Protein denotes MEF
T26731 37728-37745 Protein denotes wild-type C/EBP-β
T26695 37763-37796 Protein denotes C/EBP-β phospho-acceptor mutants,
T26741 37808-37859 Protein denotes the pGLmP-539 SerpinB2 promoter-luciferase reporter
T26711 37813-37817 Protein denotes GLmP
T26701 37864-37888 Protein denotes β-galactosidase reporter
T26717 37919-37922 Entity denotes LPS
T26715 37927-37932 Protein denotes 4 hrs
T26736 37934-37944 Protein denotes Luciferase
T26734 37987-38002 Protein denotes β-galactosidase
T26698 38076-38123 Protein denotes the respective C/EBP-β phospho-acceptor mutants
T26710 38125-38159 Protein denotes The C/EBP-βT217A -transfected MEFs
T26720 38129-38154 Protein denotes C/EBP-βT217A -transfected
T26697 38207-38214 Protein denotes C/EBP-β
T26693 38334-38347 Protein denotes one-way ANOVA
T17633 38351-38453 Regulation denotes Phosphorylation of C/EBP-β at Serine 64 negatively Regulates LPS-stimulated SerpinB2 Promoter Activity
T17561 38367-38377 Protein denotes of C/EBP-β
T17569 38381-38390 Entity denotes Serine 64
T17605 38412-38426 Entity denotes LPS-stimulated
T17629 38412-38453 Positive_regulation denotes LPS-stimulated SerpinB2 Promoter Activity
T17577 38427-38435 Protein denotes SerpinB2
T17590 38427-38444 Entity denotes SerpinB2 Promoter
T17625 38470-38480 Protein denotes of C/EBP-β
T17563 38563-38570 Protein denotes C/EBP-β
T17635 38563-38679 Phosphorylation denotes C/EBP-β phosphorylation sites that may be important for LPS-stimulated SerpinB2 proximal promoter activity (Fig. 8B)
T17604 38563-38679 Entity denotes C/EBP-β phosphorylation sites that may be important for LPS-stimulated SerpinB2 proximal promoter activity (Fig. 8B)
T17647 38615-38679 Positive_regulation denotes for LPS-stimulated SerpinB2 proximal promoter activity (Fig. 8B)
T17584 38619-38633 Entity denotes LPS-stimulated
T17597 38634-38642 Protein denotes SerpinB2
T17627 38634-38660 Entity denotes SerpinB2 proximal promoter
T17600 38705-38737 Protein denotes C/EBP-β phospho-acceptor mutants
T17559 38760-38769 Entity denotes threonine
T17579 38760-38787 Entity denotes threonine or serine residue
T17601 38773-38779 Entity denotes serine
T17618 38806-38813 Entity denotes alanine
T17592 38826-38892 Protein denotes the pGLmP-539 murine SerpinB2 luciferase reporter in Cebpb−/− MEFs
T17614 38832-38835 Protein denotes LmP
T17551 38879-38892 Protein denotes Cebpb−/− MEFs
T17649 38894-38938 Gene_expression denotes Re-expression of wild-type C/EBP-β in Cebpb−
T17574 38908-38928 Protein denotes of wild-type C/EBP-β
T17578 38932-38938 Protein denotes Cebpb−
T17554 38941-38945 Protein denotes MEFs
T17631 38941-39038 Positive_regulation denotes MEFs significantly stimulated SerpinB2 luciferase reporter gene expression in the presence of LPS
T17589 38971-38979 Protein denotes SerpinB2
T17634 38971-39015 Gene_expression denotes SerpinB2 luciferase reporter gene expression
T17628 38980-38990 Protein denotes luciferase
T17622 39000-39004 Protein denotes gene
T17570 39035-39038 Entity denotes LPS
T17588 39051-39054 Protein denotes Fig
T17564 39093-39103 Protein denotes of C/EBP-β
T17585 39107-39118 Entity denotes LPS-induced
T17644 39107-39146 Transcription denotes LPS-induced SerpinB2 gene transcription
T17572 39119-39127 Protein denotes SerpinB2
T17593 39119-39132 Protein denotes SerpinB2 gene
T17648 39148-39198 Gene_expression denotes Expression of the C/EBP-β phospho-acceptor mutant,
T17603 39159-39198 Protein denotes of the C/EBP-β phospho-acceptor mutant,
T17599 39199-39221 Protein denotes C/EBPβT217A, in Cebpb−
T17624 39215-39221 Protein denotes Cebpb−
T17565 39224-39228 Protein denotes MEFs
T17609 39260-39268 Protein denotes SerpinB2
T17626 39260-39277 Entity denotes SerpinB2 promoter
T17573 39301-39318 Protein denotes wild-type C/EBP-β
T17567 39320-39323 Protein denotes Fig
T17571 39369-39379 Protein denotes of C/EBP-β
T17594 39383-39387 Entity denotes T217
T17621 39431-39439 Protein denotes SerpinB2
T17568 39431-39448 Entity denotes SerpinB2 promoter
T17602 39473-39476 Entity denotes LPS
T17607 39478-39485 Protein denotes C/EBP-β
T17619 39495-39527 Entity denotes additional phosphorylation sites
T17560 39545-39555 Protein denotes C/EBP-βS64
T17642 39589-39648 Regulation denotes in modulating C/EBP-β-dependent SerpinB2 gene transcription
T17611 39603-39620 Protein denotes C/EBP-β-dependent
T17650 39603-39648 Transcription denotes C/EBP-β-dependent SerpinB2 gene transcription
T17645 39603-39648 Regulation denotes C/EBP-β-dependent SerpinB2 gene transcription
T17583 39621-39629 Protein denotes SerpinB2
T17617 39621-39634 Protein denotes SerpinB2 gene
T17598 39650-39661 Protein denotes C/EBP-βT188
T17638 39679-39696 Regulation denotes regulating DAPK1,
T17620 39690-39696 Protein denotes DAPK1,
T17582 39697-39780 Protein denotes an IFNγ-inducible gene involved in the regulation of cell cycle and apoptosis [38],
T17550 39842-39852 Protein denotes C/EBP-βS64
T17637 39866-39932 Transcription denotes for LPS-induced transcription of the cytokines IL-6 and MCP-1 [64]
T17636 39866-39932 Transcription denotes for LPS-induced transcription of the cytokines IL-6 and MCP-1 [64]
T17586 39870-39881 Entity denotes LPS-induced
T17595 39899-39917 Protein denotes the cytokines IL-6
T17587 39899-39917 Protein denotes the cytokines IL-6
T17553 39922-39927 Protein denotes MCP-1
T17606 39945-39953 Protein denotes SerpinB2
T17643 39945-40023 Regulation denotes SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
T17640 39945-40023 Positive_regulation denotes SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
T17639 39945-40023 Gene_expression denotes SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
T17612 39965-39971 Entity denotes by LPS
T17576 40006-40023 Protein denotes to cytokines [29]
T17591 40117-40124 Protein denotes C/EBP-β
T17596 40129-40137 Protein denotes SerpinB2
T17558 40163-40191 Entity denotes these phospho-acceptor sites
T17557 40177-40185 Entity denotes acceptor
T17580 40211-40219 Protein denotes SerpinB2
T17646 40211-40235 Gene_expression denotes SerpinB2 gene expression
T17575 40237-40261 Protein denotes C/EBP-βT188A-transfected
T17562 40237-40266 Protein denotes C/EBP-βT188A-transfected MEFs
T17615 40277-40285 Protein denotes SerpinB2
T17555 40277-40294 Entity denotes SerpinB2 promoter
T17613 40323-40357 Protein denotes wild-type C/EBP-β-transfected MEFs
T17549 40333-40352 Protein denotes C/EBP-β-transfected
T17630 40367-40396 Gene_expression denotes the expression of C/EBP-βS64A
T17610 40382-40396 Protein denotes of C/EBP-βS64A
T17608 40409-40417 Protein denotes SerpinB2
T17566 40409-40426 Entity denotes SerpinB2 promoter
T17556 40451-40454 Entity denotes LPS
T17616 40456-40459 Protein denotes Fig
T17632 40497-40530 Phosphorylation denotes phosphorylation of C/EBP-β at S64
T17623 40513-40523 Protein denotes of C/EBP-β
T17552 40527-40530 Entity denotes S64
T17641 40539-40567 Regulation denotes negatively regulate SerpinB2
T17581 40559-40567 Protein denotes SerpinB2
T21024 40608-40619 Entity denotes Macrophages
T20987 40773-40800 Entity denotes the bacterial endotoxin LPS
T21078 40812-40823 Entity denotes macrophages
T21114 40876-40929 Positive_regulation denotes massive induction of the pro-survival factor SerpinB2
T21113 40876-40929 Gene_expression denotes massive induction of the pro-survival factor SerpinB2
T21003 40894-40929 Protein denotes of the pro-survival factor SerpinB2
T20917 40931-40939 Protein denotes SerpinB2
T21061 40995-41005 Protein denotes IKKβ/NF-κB
T20983 40995-41005 Protein denotes IKKβ/NF-κB
T21065 41000-41005 Protein denotes NF-κB
T21080 41051-41059 Entity denotes LPS [16]
T20912 41081-41130 Protein denotes SerpinB2 gene transcription in response to LPS is
T20936 41090-41094 Protein denotes gene
T21091 41090-41108 Transcription denotes gene transcription
T21004 41144-41174 Entity denotes the SerpinB2 proximal promoter
T20982 41148-41156 Protein denotes SerpinB2
T20944 41200-41212 Protein denotes upon C/EBP-β
T21027 41214-41225 Entity denotes LPS-induced
T21097 41214-41233 Positive_regulation denotes LPS-induced C/EBP-β
T21096 41214-41233 Gene_expression denotes LPS-induced C/EBP-β
T20962 41214-41233 Protein denotes LPS-induced C/EBP-β
T20902 41269-41274 Protein denotes C/EBP
T20957 41295-41316 Protein denotes the SerpinB2 proximal
T21056 41317-41346 Entity denotes promoter in vitro and in vivo
T21048 41357-41367 Protein denotes of C/EBP-β
T21050 41378-41404 Protein denotes constitutive SerpinB2 gene
T21121 41378-41418 Transcription denotes constitutive SerpinB2 gene transcription
T21070 41391-41399 Protein denotes SerpinB2
T21077 41444-41488 Entity denotes The murine SerpinB2 proximal promoter region
T20986 41455-41463 Protein denotes SerpinB2
T20940 41497-41508 Entity denotes nucleotides
T21057 41536-41540 Entity denotes PMA-
T21083 41545-41578 Transcription denotes LPS-inducible gene transcription,
T21029 41559-41563 Protein denotes gene
T20905 41597-41600 Entity denotes PMA
T21067 41652-41655 Entity denotes LPS
T21034 41668-41690 Protein denotes of the murine SerpinB2
T20984 41700-41708 Entity denotes promoter
T21036 41731-41734 Protein denotes CRE
T21020 41743-41847 Protein denotes AP-1-like elements, demonstrated to mediate PMA-stimulated transcription of the human SERPINB2 gene [37]
T20993 41787-41801 Entity denotes PMA-stimulated
T21119 41787-41847 Transcription denotes PMA-stimulated transcription of the human SERPINB2 gene [37]
T21109 41787-41847 Positive_regulation denotes PMA-stimulated transcription of the human SERPINB2 gene [37]
T20989 41816-41847 Protein denotes of the human SERPINB2 gene [37]
T20958 41829-41837 Protein denotes SERPINB2
T20932 41869-41939 Entity denotes the murine SerpinB2 proximal promoter between nucleotides −189 and −87
T21076 41880-41888 Protein denotes SerpinB2
T21021 41915-41926 Entity denotes nucleotides
T20967 41941-41952 Entity denotes These sites
T21084 41987-42052 Regulation denotes mediating PMA-inducible transcription of the murine SerpinB2 gene
T21095 41997-42052 Transcription denotes PMA-inducible transcription of the murine SerpinB2 gene
T21002 42025-42052 Protein denotes of the murine SerpinB2 gene
T21015 42039-42047 Protein denotes SerpinB2
T21045 42109-42112 Entity denotes PMA
T21017 42167-42222 Entity denotes of the murine SerpinB2 promoter containing these sites,
T20907 42181-42189 Protein denotes SerpinB2
T20994 42210-42221 Entity denotes these sites
T20937 42223-42248 Entity denotes most of the LPS-inducible
T21026 42228-42248 Entity denotes of the LPS-inducible
T20906 42330-42346 Entity denotes nucleotides −189
T21008 42357-42360 Entity denotes LPS
T20922 42400-42405 Protein denotes C/EBP
T21058 42449-42460 Entity denotes nucleotides
T20941 42481-42499 Protein denotes the downstream CRE
T21025 42504-42508 Protein denotes AP-1
T21092 42610-42672 Binding denotes between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63],
T20923 42618-42625 Protein denotes C/EBP-β
T21006 42630-42633 Protein denotes CRE
T20935 42642-42657 Protein denotes proteins (CREB)
T20991 42652-42656 Protein denotes CREB
T21066 42662-42672 Protein denotes AP-1 [63],
T20968 42677-42684 Protein denotes C/EBP-β
T21085 42703-42773 Binding denotes to physically interact with AP-1, and NF-κB to promote gene expression
T20903 42731-42736 Protein denotes AP-1,
T21043 42741-42746 Protein denotes NF-κB
T21110 42750-42773 Positive_regulation denotes promote gene expression
T20978 42758-42762 Protein denotes gene
T21094 42758-42773 Gene_expression denotes gene expression
T21117 42812-42895 Regulation denotes Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]
T20952 42826-42830 Protein denotes CREB
T21081 42857-42895 Transcription denotes transcription of the C/EBP-β gene [67]
T21054 42871-42890 Protein denotes of the C/EBP-β gene
T20985 42878-42885 Protein denotes C/EBP-β
T20926 42912-42919 Protein denotes C/EBP-β
T21093 42960-43021 Transcription denotes both constitutive and LPS-induced SerpinB2 gene transcription
T20998 42960-43021 Protein denotes both constitutive and LPS-induced SerpinB2 gene transcription
T20999 42982-42993 Entity denotes LPS-induced
T20933 43003-43007 Protein denotes gene
T21060 43076-43084 Protein denotes SerpinB2
T21032 43103-43107 Protein denotes gene
T21089 43114-43205 Negative_regulation denotes induction in C/EBP-β-deficient peritoneal macrophages by LPS and IFNγ was severely impaired
T20975 43127-43134 Protein denotes C/EBP-β
T20911 43135-43167 Entity denotes deficient peritoneal macrophages
T21052 43171-43174 Entity denotes LPS
T21047 43179-43183 Protein denotes IFNγ
T21037 43215-43244 Entity denotes to wild-type macrophages [68]
T20971 43251-43254 Protein denotes PCR
T21103 43325-43363 Gene_expression denotes LPS-inducible SerpinB2 mRNA expression
T20970 43339-43347 Protein denotes SerpinB2
T20981 43339-43352 Protein denotes SerpinB2 mRNA
T21068 43408-43442 Entity denotes transduced peritoneal macrophages,
T21064 43472-43479 Protein denotes C/EBP-β
T20990 43484-43492 Protein denotes SerpinB2
T20979 43484-43497 Protein denotes SerpinB2 gene
T21115 43484-43511 Transcription denotes SerpinB2 gene transcription
T20995 43513-43533 Protein denotes While C/EBP proteins
T20972 43519-43524 Protein denotes C/EBP
T20980 43552-43562 Entity denotes homodimers
T20953 43566-43584 Entity denotes heterodimers [63],
T21073 43599-43606 Protein denotes C/EBP-β
T20965 43633-43638 Protein denotes C/EBP
T20956 43659-43667 Protein denotes SerpinB2
T21049 43668-43673 Protein denotes C/EBP
T20908 43726-43773 Protein denotes C/EBP-β in LPS-induced SerpinB2 gene expression
T21059 43737-43748 Entity denotes LPS-induced
T21090 43737-43773 Gene_expression denotes LPS-induced SerpinB2 gene expression
T20950 43749-43757 Protein denotes SerpinB2
T21072 43775-43798 Protein denotes C/EBP-β, like SerpinB2,
T21040 43789-43797 Protein denotes SerpinB2
T21041 43864-43867 Entity denotes LPS
T21074 43882-43910 Protein denotes other inflammatory cytokines
T20959 43936-43953 Protein denotes C/EBP-β-null mice
T20963 44008-44098 Protein denotes SerpinB2 has been demonstrated to protect from bacterial and viral-induced cell death [14]
T21086 44116-44169 Regulation denotes the regulation of SerpinB2 gene expression by C/EBP-β
T21088 44131-44158 Gene_expression denotes of SerpinB2 gene expression
T21055 44134-44142 Protein denotes SerpinB2
T21000 44134-44147 Protein denotes SerpinB2 gene
T21013 44159-44169 Protein denotes by C/EBP-β
T21005 44242-44252 Protein denotes of C/EBP-β
T21001 44256-44293 Entity denotes several different amino acid residues
T20942 44274-44284 Entity denotes amino acid
T20977 44351-44361 Protein denotes genes [63]
T21098 44365-44395 Phosphorylation denotes C/EBP-β phosphorylated on T217
T21038 44365-44395 Protein denotes C/EBP-β phosphorylated on T217
T20949 44391-44395 Entity denotes T217
T20934 44417-44435 Entity denotes rescue macrophages
T20927 44481-44498 Protein denotes lethal toxin (LT)
T21007 44550-44563 Protein denotes SerpinB2 [16]
T21022 44585-44626 Entity denotes of a C/EBP-β phospho-acceptor site mutant
T20973 44585-44626 Entity denotes of a C/EBP-β phospho-acceptor site mutant
T21030 44606-44614 Entity denotes acceptor
T20943 44628-44650 Protein denotes C/EBPβT217A, in Cebpb−
T20919 44644-44650 Protein denotes Cebpb−
T20964 44653-44657 Protein denotes MEFs
T21010 44675-44683 Protein denotes SerpinB2
T20918 44693-44701 Entity denotes promoter
T21014 44724-44742 Protein denotes wild-type C/EBP-β,
T20920 44785-44806 Entity denotes the SerpinB2 promoter
T21071 44789-44797 Protein denotes SerpinB2
T21028 44842-44845 Entity denotes LPS
T21016 44902-44932 Entity denotes the T217 phospho-acceptor site
T20955 44902-44932 Entity denotes the T217 phospho-acceptor site
T20988 44906-44910 Entity denotes T217
T21116 44950-44996 Regulation denotes for the regulation of SerpinB2 gene expression
T21118 44969-44996 Gene_expression denotes of SerpinB2 gene expression
T20928 44972-44980 Protein denotes SerpinB2
T21023 44972-44985 Protein denotes SerpinB2 gene
T21101 45009-45078 Gene_expression denotes expression of the C/EBP-β phospho-acceptor site mutant, C/EBP-βT188A,
T21082 45009-45132 Regulation denotes expression of the C/EBP-β phospho-acceptor site mutant, C/EBP-βT188A, did not affect SerpinB2 promoter activity differently true
T20996 45020-45063 Protein denotes of the C/EBP-β phospho-acceptor site mutant
T21019 45065-45077 Protein denotes C/EBP-βT188A
T20992 45094-45102 Protein denotes SerpinB2
T21046 45094-45111 Entity denotes SerpinB2 promoter
T21106 45157-45257 Positive_regulation denotes In contrast, expression of C/EBP-βS64A significantly enhanced LPS-induced SerpinB2 promoter activity
T21112 45170-45195 Gene_expression denotes expression of C/EBP-βS64A
T20997 45181-45195 Protein denotes of C/EBP-βS64A
T20909 45219-45230 Entity denotes LPS-induced
T20931 45231-45239 Protein denotes SerpinB2
T21031 45231-45248 Entity denotes SerpinB2 promoter
T21105 45259-45368 Regulation denotes indicating that phosphorylation of C/EBP-β at S64 negatively regulates LPS-induced SerpinB2 promoter activity
T21099 45275-45308 Phosphorylation denotes phosphorylation of C/EBP-β at S64
T20915 45291-45301 Protein denotes of C/EBP-β
T20939 45305-45308 Entity denotes S64
T21051 45330-45341 Entity denotes LPS-induced
T20974 45342-45350 Protein denotes SerpinB2
T20924 45342-45359 Entity denotes SerpinB2 promoter
T21062 45376-45383 Protein denotes C/EBP-β
T20904 45376-45387 Entity denotes C/EBP-β S64
T21102 45376-45458 Phosphorylation denotes C/EBP-β S64 is constitutively phosphorylated in both RAW264.7 cells and MEFs [73],
T21035 45448-45452 Protein denotes MEFs
T20947 45498-45507 Entity denotes this site
T21069 45539-45550 Entity denotes LPS-induced
T21120 45539-45576 Transcription denotes LPS-induced transcription of SerpinB2
T21012 45565-45576 Protein denotes of SerpinB2
T20938 45593-45601 Entity denotes promoter
T20925 45644-45678 Protein denotes that Mixed lineage kinase-3 (MLK3)
T20951 45673-45677 Protein denotes MLK3
T21033 45704-45718 Entity denotes of C/EBP-β S64
T21044 45707-45714 Protein denotes C/EBP-β
T21011 45737-45751 Protein denotes IFNγ-regulated
T21009 45799-45810 Protein denotes MLK3-driven
T20969 45829-45835 Entity denotes of S64
T20930 45857-45882 Entity denotes in LPS-signaling pathways
T20948 46010-46030 Entity denotes immune cells such as
T20946 46010-46042 Entity denotes immune cells such as macrophages
T20913 46110-46118 Protein denotes SerpinB2
T20921 46284-46295 Protein denotes of SerpinB2
T20976 46323-46387 Protein denotes cytokine profiles which can affect immune cell polarization [27]
T21039 46421-46428 Protein denotes C/EBP-β
T21079 46485-46498 Entity denotes immune cells,
T20929 46582-46589 Protein denotes C/EBP-β
T21087 46617-46695 Regulation denotes mediating both constitutive and LPS-induced transcription of the SerpinB2 gene
T21111 46632-46695 Transcription denotes constitutive and LPS-induced transcription of the SerpinB2 gene
T20916 46649-46660 Entity denotes LPS-induced
T20954 46675-46695 Protein denotes of the SerpinB2 gene
T21018 46682-46690 Protein denotes SerpinB2
T21042 46850-46864 Entity denotes the C/EBP site
T21063 46854-46859 Protein denotes C/EBP
T20914 46891-46899 Protein denotes SerpinB2
T20910 46891-46917 Entity denotes SerpinB2 proximal promoter
T21053 46964-46975 Entity denotes LPS-induced
T20966 46976-46984 Protein denotes SerpinB2
T21104 46976-47000 Gene_expression denotes SerpinB2 gene expression
T20961 46976-47000 Protein denotes SerpinB2 gene expression
T21107 47083-47131 Regulation denotes negatively regulating SerpinB2 promoter activity
T20945 47105-47113 Protein denotes SerpinB2
T20960 47105-47122 Entity denotes SerpinB2 promoter
T21108 47184-47250 Regulation denotes the regulation of inflammation-associated SerpinB2 gene expression
T21100 47199-47250 Gene_expression denotes of inflammation-associated SerpinB2 gene expression
T21075 47226-47234 Protein denotes SerpinB2
R10666 T14498 T14549 themeOf of endogenous SerpinB2 mRNA,constitutive and LPS-inducible transcription of endogenous SerpinB2 mRNA
R10667 T14500 T14552 themeOf mRNA,mRNA Expression in MEFs and Inflammatory Primary Macrophages
R10668 T14500 T14553 themeOf mRNA,mRNA Expression in MEFs and Inflammatory Primary Macrophages
R10669 T14501 T14545 themeOf SerpinB2 mRNA,in SerpinB2 mRNA expression
R10670 T14505 T14550 themeOf mRNA,"mRNA expression in response to LPS,"
R10671 T14505 T14551 themeOf mRNA,"mRNA expression in response to LPS,"
R10672 T14506 T14542 themeOf mRNA,mRNA expression
R10673 T14506 T14543 themeOf mRNA,mRNA expression
R10674 T14510 T14538 themeOf SerpinB2 mRNA,LPS-induced SerpinB2 mRNA expression
R10675 T14513 T14539 causeOf LPS,LPS-stimulated SerpinB2
R10676 T14519 T14544 themeOf C/EBP-β,C/EBP-β expression
R10677 T14527 T14541 causeOf LPS,LPS stimulated an increase in SerpinB2 mRNA expression in wild-type MEFs
R10678 T14529 T14539 themeOf SerpinB2,LPS-stimulated SerpinB2
R10679 T14531 T14548 themeOf SerpinB2 mRNA,endogenous SerpinB2 mRNA expression
R10680 T14538 T14537 themeOf LPS-induced SerpinB2 mRNA expression,LPS-induced SerpinB2 mRNA expression was significantly decreased in C/EBP-β-deficient inflammatory macrophages
R10681 T14540 T14541 themeOf an increase in SerpinB2 mRNA expression in wild-type MEFs,LPS stimulated an increase in SerpinB2 mRNA expression in wild-type MEFs
R10682 T14542 T14547 themeOf mRNA expression,whereas LPS-stimulated SerpinB2 mRNA expression was significantly dampened in Cebpb−
R10683 T14543 T14546 themeOf mRNA expression,whereas LPS-stimulated SerpinB2 mRNA expression was significantly dampened in Cebpb−
R10684 T14545 T14540 themeOf in SerpinB2 mRNA expression,an increase in SerpinB2 mRNA expression in wild-type MEFs
R10685 T14549 T14536 themeOf constitutive and LPS-inducible transcription of endogenous SerpinB2 mRNA,for mediating constitutive and LPS-inducible transcription of endogenous SerpinB2 mRNA
R11260 T15270 T15327 themeOf C/EBP-β,of C/EBP-β recruitment
R11261 T15271 T15328 themeOf T217-phosphorylated C/EBP-β,T217-phosphorylated C/EBP-β
R11262 T15276 T15325 themeOf p-C/EBP-βT217,p-C/EBP-βT217 was constitutively bound to the SerpinB2 proximal promoter
R11263 T15277 T15322 themeOf p-C/EBP-βT217,p-C/EBP-βT217 recruitment
R11264 T15283 T15326 themeOf C/EBP-β,C/EBP-β Binds the Murine SerpinB2 Proximal
R11265 T15293 T15297 partOf the SerpinB2 promoter,SerpinB2
R11266 T15298 T15321 themeOf C/EBP-β,C/EBP-β phosphorylation
R11267 T15299 T15320 themeOf target genes [38],transactivate target genes [38]
R11268 T15301 T15307 partOf to the SerpinB2 proximal promoter,SerpinB2
R11269 T15301 T15325 themeOf to the SerpinB2 proximal promoter,p-C/EBP-βT217 was constitutively bound to the SerpinB2 proximal promoter
R11270 T15302 T15316 partOf the SerpinB2 proximal promoter of the T217 phosphorylated C/EBP-β isoform (p-C/EBP-βT217),SerpinB2
R11271 T15303 T15323 themeOf of p-C/EBP-βT217,the binding affinity of p-C/EBP-βT217 for the SerpinB2 proximal
R11272 T15305 T15311 partOf the murine SerpinB2 promoter,SerpinB2
R11273 T15310 T15317 partOf the SerpinB2 promoter,SerpinB2
R11274 T15313 T15323 themeOf for the SerpinB2 proximal,the binding affinity of p-C/EBP-βT217 for the SerpinB2 proximal
R11275 T15315 T15271 partOf T217-phosphorylated,T217-phosphorylated C/EBP-β
R11276 T15315 T15328 siteOf T217-phosphorylated,T217-phosphorylated C/EBP-β
R11800 T16075 T16078 partOf to the SerpinB2 proximal promoter,SerpinB2
R11801 T16075 T16105 themeOf to the SerpinB2 proximal promoter,Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo
R11802 T16077 T16086 partOf SerpinB2 promoter,SerpinB2
R11803 T16087 T16104 causeOf LPS-stimulated,LPS-stimulated SerpinB2 promoter activity
R11804 T16088 T16082 partOf the SerpinB2 promoter,SerpinB2
R11805 T16094 T16102 causeOf C/EBP-β,C/EBP-β Promotes LPS-inducible Murine SerpinB2 Proximal Promoter Activity
R11806 T16097 T16105 themeOf C/EBP-β,Since C/EBP-β binds to the SerpinB2 proximal promoter in an LPS-inducible manner both in vitro and in vivo
R12674 T17552 T17623 partOf S64,of C/EBP-β
R12675 T17552 T17632 siteOf S64,phosphorylation of C/EBP-β at S64
R12676 T17553 T17637 themeOf MCP-1,for LPS-induced transcription of the cytokines IL-6 and MCP-1 [64]
R12677 T17554 T17631 causeOf MEFs,MEFs significantly stimulated SerpinB2 luciferase reporter gene expression in the presence of LPS
R12678 T17555 T17615 partOf SerpinB2 promoter,SerpinB2
R12679 T17563 T17635 themeOf C/EBP-β,C/EBP-β phosphorylation sites that may be important for LPS-stimulated SerpinB2 proximal promoter activity (Fig. 8B)
R12680 T17566 T17608 partOf SerpinB2 promoter,SerpinB2
R12681 T17568 T17621 partOf SerpinB2 promoter,SerpinB2
R12682 T17574 T17649 themeOf of wild-type C/EBP-β,Re-expression of wild-type C/EBP-β in Cebpb−
R12683 T17580 T17646 themeOf SerpinB2,SerpinB2 gene expression
R12684 T17581 T17641 themeOf SerpinB2,negatively regulate SerpinB2
R12685 T17584 T17647 causeOf LPS-stimulated,for LPS-stimulated SerpinB2 proximal promoter activity (Fig. 8B)
R12686 T17590 T17577 partOf SerpinB2 Promoter,SerpinB2
R12687 T17593 T17644 themeOf SerpinB2 gene,LPS-induced SerpinB2 gene transcription
R12688 T17595 T17636 themeOf the cytokines IL-6,for LPS-induced transcription of the cytokines IL-6 and MCP-1 [64]
R12689 T17603 T17648 themeOf "of the C/EBP-β phospho-acceptor mutant,","Expression of the C/EBP-β phospho-acceptor mutant,"
R12690 T17605 T17629 causeOf LPS-stimulated,LPS-stimulated SerpinB2 Promoter Activity
R12691 T17606 T17639 themeOf SerpinB2,SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
R12692 T17606 T17640 themeOf SerpinB2,SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
R12693 T17606 T17643 themeOf SerpinB2,SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
R12694 T17610 T17630 themeOf of C/EBP-βS64A,the expression of C/EBP-βS64A
R12695 T17611 T17645 causeOf C/EBP-β-dependent,C/EBP-β-dependent SerpinB2 gene transcription
R12696 T17612 T17640 causeOf by LPS,SerpinB2 is induced by LPS and regulated in a manner similar to cytokines [29]
R12697 T17617 T17650 themeOf SerpinB2 gene,C/EBP-β-dependent SerpinB2 gene transcription
R12698 T17620 T17638 themeOf "DAPK1,","regulating DAPK1,"
R12699 T17622 T17634 themeOf gene,SerpinB2 luciferase reporter gene expression
R12700 T17623 T17632 themeOf of C/EBP-β,phosphorylation of C/EBP-β at S64
R12701 T17626 T17609 partOf SerpinB2 promoter,SerpinB2
R12702 T17627 T17597 partOf SerpinB2 proximal promoter,SerpinB2
R12703 T17634 T17631 themeOf SerpinB2 luciferase reporter gene expression,MEFs significantly stimulated SerpinB2 luciferase reporter gene expression in the presence of LPS
R12704 T17650 T17642 themeOf C/EBP-β-dependent SerpinB2 gene transcription,in modulating C/EBP-β-dependent SerpinB2 gene transcription
R12705 T17650 T17645 themeOf C/EBP-β-dependent SerpinB2 gene transcription,C/EBP-β-dependent SerpinB2 gene transcription
R14932 T20903 T21085 themeOf "AP-1,","to physically interact with AP-1, and NF-κB to promote gene expression"
R14933 T20904 T21062 partOf C/EBP-β S64,C/EBP-β
R14934 T20904 T21102 siteOf C/EBP-β S64,"C/EBP-β S64 is constitutively phosphorylated in both RAW264.7 cells and MEFs [73],"
R14935 T20915 T21099 themeOf of C/EBP-β,phosphorylation of C/EBP-β at S64
R14936 T20933 T21093 themeOf gene,both constitutive and LPS-induced SerpinB2 gene transcription
R14937 T20935 T21092 themeOf proteins (CREB),"between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63],"
R14938 T20936 T21091 themeOf gene,gene transcription
R14939 T20939 T20915 partOf S64,of C/EBP-β
R14940 T20939 T21099 siteOf S64,phosphorylation of C/EBP-β at S64
R14941 T20949 T21038 partOf T217,C/EBP-β phosphorylated on T217
R14942 T20949 T21098 siteOf T217,C/EBP-β phosphorylated on T217
R14943 T20950 T21090 themeOf SerpinB2,LPS-induced SerpinB2 gene expression
R14944 T20952 T21117 causeOf CREB,"Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]"
R14945 T20954 T21111 themeOf of the SerpinB2 gene,constitutive and LPS-induced transcription of the SerpinB2 gene
R14946 T20962 T21096 themeOf LPS-induced C/EBP-β,LPS-induced C/EBP-β
R14947 T20962 T21097 themeOf LPS-induced C/EBP-β,LPS-induced C/EBP-β
R14948 T20966 T21104 themeOf SerpinB2,SerpinB2 gene expression
R14949 T20978 T21094 themeOf gene,gene expression
R14950 T20979 T21115 themeOf SerpinB2 gene,SerpinB2 gene transcription
R14951 T20981 T21103 themeOf SerpinB2 mRNA,LPS-inducible SerpinB2 mRNA expression
R14952 T20989 T21119 themeOf of the human SERPINB2 gene [37],PMA-stimulated transcription of the human SERPINB2 gene [37]
R14953 T20993 T21109 causeOf PMA-stimulated,PMA-stimulated transcription of the human SERPINB2 gene [37]
R14954 T20996 T21101 themeOf of the C/EBP-β phospho-acceptor site mutant,"expression of the C/EBP-β phospho-acceptor site mutant, C/EBP-βT188A,"
R14955 T20997 T21112 themeOf of C/EBP-βS64A,expression of C/EBP-βS64A
R14956 T21000 T21088 themeOf SerpinB2 gene,of SerpinB2 gene expression
R14957 T21002 T21095 themeOf of the murine SerpinB2 gene,PMA-inducible transcription of the murine SerpinB2 gene
R14958 T21003 T21113 themeOf of the pro-survival factor SerpinB2,massive induction of the pro-survival factor SerpinB2
R14959 T21003 T21114 themeOf of the pro-survival factor SerpinB2,massive induction of the pro-survival factor SerpinB2
R14960 T21012 T21120 themeOf of SerpinB2,LPS-induced transcription of SerpinB2
R14961 T21013 T21086 causeOf by C/EBP-β,the regulation of SerpinB2 gene expression by C/EBP-β
R14962 T21023 T21118 themeOf SerpinB2 gene,of SerpinB2 gene expression
R14963 T21027 T21097 causeOf LPS-induced,LPS-induced C/EBP-β
R14964 T21029 T21083 themeOf gene,"LPS-inducible gene transcription,"
R14965 T21038 T21098 themeOf C/EBP-β phosphorylated on T217,C/EBP-β phosphorylated on T217
R14966 T21043 T21085 themeOf NF-κB,"to physically interact with AP-1, and NF-κB to promote gene expression"
R14967 T21050 T21121 themeOf constitutive SerpinB2 gene,constitutive SerpinB2 gene transcription
R14968 T21054 T21081 themeOf of the C/EBP-β gene,transcription of the C/EBP-β gene [67]
R14969 T21062 T21102 themeOf C/EBP-β,"C/EBP-β S64 is constitutively phosphorylated in both RAW264.7 cells and MEFs [73],"
R14970 T21066 T21092 themeOf "AP-1 [63],","between C/EBP-β and CRE binding proteins (CREB) and AP-1 [63],"
R14971 T21075 T21100 themeOf SerpinB2,of inflammation-associated SerpinB2 gene expression
R14972 T21081 T21117 themeOf transcription of the C/EBP-β gene [67],"Additionally, CREB has been shown to control transcription of the C/EBP-β gene [67]"
R14973 T21088 T21086 themeOf of SerpinB2 gene expression,the regulation of SerpinB2 gene expression by C/EBP-β
R14974 T21094 T21110 themeOf gene expression,promote gene expression
R14975 T21095 T21084 themeOf PMA-inducible transcription of the murine SerpinB2 gene,mediating PMA-inducible transcription of the murine SerpinB2 gene
R14976 T21099 T21105 causeOf phosphorylation of C/EBP-β at S64,indicating that phosphorylation of C/EBP-β at S64 negatively regulates LPS-induced SerpinB2 promoter activity
R14977 T21100 T21108 themeOf of inflammation-associated SerpinB2 gene expression,the regulation of inflammation-associated SerpinB2 gene expression
R14978 T21101 T21082 causeOf "expression of the C/EBP-β phospho-acceptor site mutant, C/EBP-βT188A,","expression of the C/EBP-β phospho-acceptor site mutant, C/EBP-βT188A, did not affect SerpinB2 promoter activity differently"
R14979 T21111 T21087 themeOf constitutive and LPS-induced transcription of the SerpinB2 gene,mediating both constitutive and LPS-induced transcription of the SerpinB2 gene
R14980 T21112 T21106 causeOf expression of C/EBP-βS64A,"In contrast, expression of C/EBP-βS64A significantly enhanced LPS-induced SerpinB2 promoter activity"
R14981 T21118 T21116 themeOf of SerpinB2 gene expression,for the regulation of SerpinB2 gene expression
R14982 T21119 T21109 themeOf PMA-stimulated transcription of the human SERPINB2 gene [37],PMA-stimulated transcription of the human SERPINB2 gene [37]
R1599 T2461 T2481 causeOf LPS-dependent,for LPS-dependent transcription
R1600 T2470 T2475 themeOf LPS induction of SerpinB2,LPS induction of SerpinB2 is dependent upon cis-acting
R1601 T2371 T2480 themeOf upon a C/EBP binding site,upon a C/EBP binding site
R1602 T2373 T2472 themeOf SerpinB2,constitutive SerpinB2 expression
R1603 T2471 T2476 themeOf LPS induction of SerpinB2,LPS induction of SerpinB2 is dependent upon cis-acting
R1604 T2382 T2468 themeOf C/EBP-β,C/EBP-β directly bound to this site in vivo
R1606 T2385 T2473 themeOf of LPS,The binding of LPS to TLR4 on the surface of macrophages
R1607 T2390 T2471 causeOf LPS,LPS induction of SerpinB2
R1608 T2393 T2487 themeOf of the SerpinB2 gene,the transcriptional regulation of the SerpinB2 gene
R1609 T2395 T2479 locationOf intracellular,a nonglycosylated intracellular protein [10]
R1610 T2397 T2485 causeOf by LPS,SerpinB2 induction by LPS
R1611 T2403 T2474 themeOf of adaptor molecules,the recruitment of adaptor molecules
R1613 T2406 T2483 themeOf IFN-γ,IFN-γ co-stimulation [4]
R1615 T2408 T2484 themeOf cytokine,"the initiation of innate immune responses, including cytokine release"
R1618 T2414 T2465 themeOf a nonglycosylated intracellular protein [10],a nonglycosylated intracellular protein [10]
R1619 T2414 T2479 themeOf a nonglycosylated intracellular protein [10],a nonglycosylated intracellular protein [10]
R1620 T2415 T2485 themeOf SerpinB2,SerpinB2 induction by LPS
R1621 T2415 T2486 themeOf SerpinB2,SerpinB2 induction by LPS
R1625 T2423 T2482 causeOf a C/EBP-β phospho-acceptor site,"Importantly, a C/EBP-β phospho-acceptor site was found to negatively regulate LPS-induced SerpinB2 promoter activity"
R16264 T22555 T22571 themeOf SerpinB2 protein,analysis of SerpinB2 protein expression in whole cell lysates
R16265 T22558 T22572 themeOf protein,protein expression
R1627 T2425 T2381 partOf SerpinB2 promoter,SerpinB2
R1630 T2431 T2443 partOf the SerpinB2 promoter,SerpinB2
R1632 T2434 T2376 partOf "the murine SerpinB2 promoter,",SerpinB2
R1634 T2435 T2477 causeOf mitogen,mitogen-activated protein kinase (MAPK)
R1636 T2439 T2429 partOf the SerpinB2 promoter responsible for LPS-dependent transcription,SerpinB2
R1637 T2440 T2467 themeOf The SerpinB2 gene,The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]
R1640 T2444 T2470 themeOf of SerpinB2,LPS induction of SerpinB2
R1641 T2444 T2471 themeOf of SerpinB2,LPS induction of SerpinB2
R1644 T2451 T2466 themeOf of protein kinases,the activation of protein kinases
R1646 T2452 T2469 themeOf of plasminogen,the activation of plasminogen
R1649 T2459 T2477 themeOf protein kinase (MAPK),mitogen-activated protein kinase (MAPK)
R1651 T2460 T2473 themeOf to TLR4,The binding of LPS to TLR4 on the surface of macrophages
R16590 T23061 T23070 partOf murine SerpinB2 promoter-luciferase,murine SerpinB2 promoter-luciferase
R16591 T23071 T23081 partOf the murine SerpinB2 promoter,SerpinB2
R16981 T23608 T23624 partOf of the murine SerpinB2 promoter,SerpinB2
R16982 T23620 T23613 partOf murine SerpinB2 promoters,SerpinB2
R17238 T23991 T23989 partOf of the murine SerpinB2 promoter,SerpinB2
R17239 T23997 T23984 partOf of the murine SerpinB2 promoter,SerpinB2
R17428 T24313 T24331 partOf the murine SerpinB2 proximal promoter C/EBP,SerpinB2
R17898 T25003 T25031 themeOf SerpinB2 mRNA,SerpinB2 mRNA expression
R17899 T25011 T25033 themeOf mRNA,mRNA expression in untreated Cebpb+/+
R17900 T25011 T25034 themeOf mRNA,mRNA expression in untreated Cebpb+/+
R17901 T25016 T25036 themeOf SerpinB2 mRNA,qPCR analysis of murine SerpinB2 mRNA expression in the lentiviral transduced peritoneal macrophages
R17902 T25021 T25032 themeOf SerpinB2 mRNA,for constitutive and LPS-induced SerpinB2 mRNA expression
R17903 T25031 T25035 themeOf SerpinB2 mRNA expression,SerpinB2 mRNA expression is abrogated in Cebpb−/−
R18338 T25720 T25733 partOf the murine SerpinB2 promoter in vivo,SerpinB2
R18339 T25728 T25740 themeOf rIgG,the rIgG control
R18340 T25730 T25741 themeOf the SerpinB2 promoter suggests,the SerpinB2 promoter suggests active transcription following LPS stimulation
R18877 T26696 T26746 themeOf LPS-stimulated Cebpb+/+ MEFs,LPS-stimulated Cebpb+/+ MEFs
R18878 T26700 T26745 themeOf gene,C/EBP-β gene schematic depicting gene structure
R18879 T26706 T26743 causeOf LPS-stimulated,LPS-stimulated SerpinB2 promoter activity
R18880 T26718 T26713 partOf SerpinB2 promoter,SerpinB2
R18881 T26721 T26746 causeOf LPS-stimulated,LPS-stimulated Cebpb+/+ MEFs
R18882 T26727 T26699 partOf The SerpinB2 proximal promoter,SerpinB2
R18883 T26728 T26737 partOf SerpinB2 proximal promoter,SerpinB2
R18884 T26730 T26744 themeOf the pGLmP-539 SerpinB2 promoter-luciferase reporter,MEFs expressing the pGLmP-539 SerpinB2 promoter-luciferase reporter in the presence or absence of LPS
R2698 T3710 T3719 themeOf TaqMan® Gene,TaqMan® Gene Expression 20X primers
R2951 T4039 T4044 partOf of the murine SerpinB2 promoter,SerpinB2
R3290 T4484 T4500 themeOf a purified recombinant GST-murine SerpinB2 fusion protein produced in E. coli,a purified recombinant GST-murine SerpinB2 fusion protein produced in E. coli
R348 T748 T759 themeOf SerpinB2,SerpinB2 expression
R349 T749 T758 themeOf of Murine SerpinB2,LPS-Inducible Transcription of Murine SerpinB2
R350 T755 T762 themeOf C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression,C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression
R351 T756 T755 themeOf of inflammation-associated SerpinB2 expression,C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression
R3841 T5407 T5443 partOf the SerpinB2 promoter (−3261 to +92),SerpinB2
R3842 T5447 T5448 partOf of the wild-type murine SerpinB2 promoter,SerpinB2
R3843 T5469 T5461 partOf the SerpinB2 promoter LPS-responsive,SerpinB2
R4504 T6355 T6367 causeOf LPS,where co-transfected C/EBP-β or LPS affected pRL-TK activity
R4505 T6362 T6366 causeOf co-transfected C/EBP-β,where co-transfected C/EBP-β or LPS affected pRL-TK activity
R5402 T7575 T7596 themeOf of the C/EBP-β phospho-acceptor mutant proteins,Expression of the C/EBP-β phospho-acceptor mutant proteins
R5780 T8041 T8058 themeOf Antibodies,Antibodies were purchased from Santa Cruz
R6236 T8596 T8618 themeOf the bound chromatin,the bound chromatin
R6237 T8601 T8590 partOf the SerpinB2 proximal promoter,SerpinB2
R6781 T9261 T9281 themeOf SerpinB2 mRNA,of LPS-inducible SerpinB2 mRNA expression
R6782 T9269 T9279 themeOf gene,in gene transcription
R6783 T9275 T9280 themeOf SerpinB2,LPS-induced SerpinB2 expression
R6784 T9279 T9282 themeOf in gene transcription,an increase in gene transcription
R716 T706 T762 causeOf C/EBP-β-dependent,C/EBP-β-dependent regulation of inflammation-associated SerpinB2 expression
R719 T718 T757 themeOf of C/EBP-β containing complexes with the SerpinB2 promoter,the formation of C/EBP-β containing complexes with the SerpinB2 promoter
R721 T719 T760 themeOf 24 hrs in murine macrophages,24 hrs in murine macrophages
R723 T724 T760 locationOf murine macrophages,24 hrs in murine macrophages
R724 T727 T756 themeOf SerpinB2,of inflammation-associated SerpinB2 expression
R728 T738 T761 themeOf the human SERPINB2 promoter conserved in the mouse,the human SERPINB2 promoter conserved in the mouse
R7300 T9976 T10001 partOf the murine SerpinB2 promoter,SerpinB2
R7301 T9982 T9981 partOf of the murine SerpinB2 promoter,SerpinB2
R7302 T9989 T10014 partOf of the SerpinB2 promoter,SerpinB2
R7303 T9999 T9995 partOf The SerpinB2 Proximal Promoter,The SerpinB2 Proximal Promoter
R7304 T10006 T9985 partOf the murine SerpinB2 promoter,SerpinB2
R7305 T10007 T10018 themeOf SerpinB2 gene,PMA-induced SerpinB2 gene regulation has been extensively studied in human macrophage cell lines [45]
R8021 T10957 T10975 themeOf potential binding sites for PU.1 (−412/−407) and Oct-1,potential binding sites for PU.1 (−412/−407) and Oct-1
R8022 T10962 T10977 themeOf SerpinB2,of SerpinB2 gene expression [52]
R8023 T10977 T10976 themeOf of SerpinB2 gene expression [52],the regulation of SerpinB2 gene expression [52]
R8839 T11984 T12040 causeOf sites for transcription factors previously reported to mediate LPS-inducible transcription in other genes [57],sites for transcription factors previously reported to mediate LPS-inducible transcription in other genes [57]
R8840 T12007 T12043 causeOf CRE,"C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription"
R8841 T12008 T12041 causeOf C/EBP,"C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription"
R8842 T12013 T12039 themeOf of the SerpinB2 gene,LPS-induced activation of the SerpinB2 gene
R8843 T12024 T12044 themeOf C/EBP,have also recently implicated this C/EBP site in LPS-induced activation of the SerpinB2 gene
R8844 T12031 T12042 causeOf Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter,"C/EBP, CRE and Two AP-1 Sites in the Murine SerpinB2 Gene Proximal Promoter are Essential for Optimal LPS-inducible Transcription"
R9458 T12760 T12797 themeOf a LPS-inducible complex that is likely to contain a member of the C/EBP family of transcription factors,Together these data indicate that the putative SerpinB2 C/EBP site at −203/−192 binds a LPS-inducible complex that is likely to contain a member of the C/EBP family of transcription factors
R9459 T12764 T12778 partOf the rat albumin promoter,albumin
R9460 T12770 T12799 themeOf a high affinity C/EBP binding site,a high affinity C/EBP binding site
R9461 T12779 T12797 themeOf the putative SerpinB2 C/EBP site,Together these data indicate that the putative SerpinB2 C/EBP site at −203/−192 binds a LPS-inducible complex that is likely to contain a member of the C/EBP family of transcription factors
R9462 T12780 T12798 themeOf of a known C/EBP binding site from the rat albumin promoter,of a known C/EBP binding site from the rat albumin promoter
R9463 T12787 T12781 partOf the rat albumin promoter,albumin