Id |
Subject |
Object |
Predicate |
Lexical cue |
T13760 |
32-36 |
Protein |
denotes |
WWOX |
T13720 |
74-78 |
Protein |
denotes |
WWOX |
T13711 |
88-102 |
Entity |
denotes |
two N-terminal |
T13751 |
88-127 |
Entity |
denotes |
two N-terminal WW domains, a C-terminal |
T13694 |
88-127 |
Entity |
denotes |
two N-terminal WW domains, a C-terminal |
T13754 |
140-185 |
Entity |
denotes |
alcohol dehydrogenase/reductase (SDR) domain, |
T13732 |
148-177 |
Protein |
denotes |
dehydrogenase/reductase (SDR) |
T13715 |
173-176 |
Protein |
denotes |
SDR |
T13696 |
192-194 |
Entity |
denotes |
D3 |
T13698 |
253-267 |
Entity |
denotes |
the WW domains |
T13707 |
269-280 |
Entity |
denotes |
Chang et al |
T13728 |
295-309 |
Protein |
denotes |
Del Mare et al |
T13712 |
295-309 |
Entity |
denotes |
Del Mare et al |
T13702 |
365-379 |
Entity |
denotes |
The SDR domain |
T13743 |
369-372 |
Protein |
denotes |
SDR |
T13775 |
435-475 |
Binding |
denotes |
conserved tyrosine phosphorylation sites |
T13722 |
435-475 |
Entity |
denotes |
conserved tyrosine phosphorylation sites |
T13756 |
445-453 |
Entity |
denotes |
tyrosine |
T13691 |
477-482 |
Entity |
denotes |
Tyr33 |
T13762 |
487-493 |
Entity |
denotes |
Tyr287 |
T13766 |
495-522 |
Entity |
denotes |
Other phosphorylation sites |
T13723 |
559-563 |
Entity |
denotes |
Tyr6 |
T13733 |
565-570 |
Entity |
denotes |
Thr12 |
T13765 |
572-577 |
Entity |
denotes |
Ser14 |
T13692 |
579-584 |
Entity |
denotes |
Tyr61 |
T13726 |
586-592 |
Entity |
denotes |
Tyr293 |
T13706 |
645-649 |
Protein |
denotes |
WWOX |
T13770 |
645-676 |
Phosphorylation |
denotes |
WWOX is phosphorylated in Tyr33 |
T13768 |
645-690 |
Binding |
denotes |
WWOX is phosphorylated in Tyr33 and binds p53 |
T13731 |
671-676 |
Entity |
denotes |
Tyr33 |
T13739 |
687-690 |
Protein |
denotes |
p53 |
T13688 |
692-712 |
Entity |
denotes |
The WWOX/p53 complex |
T13701 |
692-712 |
Protein |
denotes |
The WWOX/p53 complex |
T13721 |
701-704 |
Protein |
denotes |
p53 |
T13690 |
734-746 |
Entity |
denotes |
mitochondria |
T13710 |
750-757 |
Entity |
denotes |
nucleus |
T13736 |
779-783 |
Protein |
denotes |
WWOX |
T13763 |
795-798 |
Protein |
denotes |
PPx |
T13727 |
795-799 |
Entity |
denotes |
PPxY |
T13717 |
817-872 |
Protein |
denotes |
transcription factors, such as RUNX2, c-Jun, and ERBB4, |
T13695 |
855-861 |
Protein |
denotes |
c-Jun, |
T13704 |
866-871 |
Protein |
denotes |
ERBB4 |
T13689 |
877-897 |
Entity |
denotes |
its first WW domain, |
T13693 |
934-951 |
Protein |
denotes |
of these proteins |
T13759 |
973-986 |
Entity |
denotes |
the cytoplasm |
T13699 |
988-992 |
Protein |
denotes |
WWOX |
T13773 |
988-1021 |
Binding |
denotes |
WWOX binds Tau via its SDR domain |
T13749 |
999-1002 |
Protein |
denotes |
Tau |
T13747 |
1007-1021 |
Entity |
denotes |
its SDR domain |
T13761 |
1011-1014 |
Protein |
denotes |
SDR |
T13718 |
1023-1027 |
Protein |
denotes |
WWOX |
T13744 |
1044-1076 |
Protein |
denotes |
the Wnt/β-catenin signal pathway |
T13730 |
1052-1061 |
Protein |
denotes |
β-catenin |
T13771 |
1080-1091 |
Binding |
denotes |
binding Dvl |
T13705 |
1088-1091 |
Protein |
denotes |
Dvl |
T13746 |
1127-1134 |
Entity |
denotes |
Phorbol |
T13755 |
1127-1140 |
Entity |
denotes |
Phorbol ester |
T13767 |
1127-1205 |
Positive_regulation |
denotes |
Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell |
T13758 |
1169-1205 |
Entity |
denotes |
of MEK/WWOX complex in Jurkat T cell |
T13740 |
1169-1205 |
Entity |
denotes |
of MEK/WWOX complex in Jurkat T cell |
T13757 |
1176-1180 |
Protein |
denotes |
WWOX |
T13748 |
1192-1205 |
Entity |
denotes |
Jurkat T cell |
T13769 |
1211-1228 |
Regulation |
denotes |
the released WWOX |
T13700 |
1211-1228 |
Protein |
denotes |
the released WWOX |
T13752 |
1245-1284 |
Entity |
denotes |
the mitochondria for causing cell death |
T13735 |
1286-1290 |
Protein |
denotes |
WWOX |
T13697 |
1311-1319 |
Entity |
denotes |
membrane |
T13772 |
1328-1369 |
Binding |
denotes |
association with Hyal-2 and phospho-Ezrin |
T13703 |
1345-1351 |
Protein |
denotes |
Hyal-2 |
T13753 |
1356-1369 |
Protein |
denotes |
phospho-Ezrin |
T13741 |
1371-1377 |
Protein |
denotes |
Hyal-2 |
T13745 |
1396-1404 |
Protein |
denotes |
receptor |
T13742 |
1409-1415 |
Protein |
denotes |
TGF-β1 |
T13719 |
1432-1478 |
Protein |
denotes |
TGF-β1, WWOX binds Hyal-2 and forms a complex, |
T13714 |
1440-1444 |
Protein |
denotes |
WWOX |
T13774 |
1440-1457 |
Binding |
denotes |
WWOX binds Hyal-2 |
T13737 |
1451-1457 |
Protein |
denotes |
Hyal-2 |
T13709 |
1468-1477 |
Entity |
denotes |
a complex |
T13708 |
1505-1516 |
Entity |
denotes |
the nucleus |
T13724 |
1547-1555 |
Entity |
denotes |
promoter |
T13713 |
1566-1571 |
Protein |
denotes |
Ack1, |
T13750 |
1566-1649 |
Protein |
denotes |
Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, |
T13725 |
1566-1649 |
Protein |
denotes |
Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, |
T13734 |
1617-1648 |
Protein |
denotes |
hyaluronoglucosaminidase 2; CKI |
T13687 |
1650-1656 |
Protein |
denotes |
casein |
T13764 |
1650-1694 |
Protein |
denotes |
casein kinase; GSK, glycogen synthase kinase |
T13738 |
1650-1694 |
Protein |
denotes |
casein kinase; GSK, glycogen synthase kinase |
T13729 |
1650-1694 |
Protein |
denotes |
casein kinase; GSK, glycogen synthase kinase |
T13716 |
1696-1717 |
Protein |
denotes |
PKA, protein kinase A |
R9475 |
T13699 |
T13773 |
themeOf |
WWOX,WWOX binds Tau via its SDR domain |
R9476 |
T13700 |
T13769 |
themeOf |
the released WWOX,the released WWOX |
R9477 |
T13703 |
T13772 |
themeOf |
Hyal-2,association with Hyal-2 and phospho-Ezrin |
R9478 |
T13705 |
T13771 |
themeOf |
Dvl,binding Dvl |
R9479 |
T13706 |
T13768 |
themeOf |
WWOX,WWOX is phosphorylated in Tyr33 and binds p53 |
R9480 |
T13706 |
T13770 |
themeOf |
WWOX,WWOX is phosphorylated in Tyr33 |
R9481 |
T13714 |
T13774 |
themeOf |
WWOX,WWOX binds Hyal-2 |
R9482 |
T13722 |
T13775 |
themeOf |
conserved tyrosine phosphorylation sites,conserved tyrosine phosphorylation sites |
R9483 |
T13731 |
T13706 |
partOf |
Tyr33,WWOX |
R9484 |
T13731 |
T13770 |
siteOf |
Tyr33,WWOX is phosphorylated in Tyr33 |
R9485 |
T13737 |
T13774 |
themeOf |
Hyal-2,WWOX binds Hyal-2 |
R9486 |
T13739 |
T13768 |
themeOf |
p53,WWOX is phosphorylated in Tyr33 and binds p53 |
R9487 |
T13747 |
T13749 |
partOf |
its SDR domain,Tau |
R9488 |
T13747 |
T13773 |
siteOf |
its SDR domain,WWOX binds Tau via its SDR domain |
R9489 |
T13749 |
T13773 |
themeOf |
Tau,WWOX binds Tau via its SDR domain |
R9490 |
T13753 |
T13772 |
themeOf |
phospho-Ezrin,association with Hyal-2 and phospho-Ezrin |
R9491 |
T13755 |
T13767 |
causeOf |
Phorbol ester,Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell |