bionlp-st-ge-2016-test-ihmc  

PMC:3586680 / 1079-6633 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2466 176-182 Entity denotes Silber
T2488 346-360 Entity denotes Friedman et al
T2463 502-512 Entity denotes Haar et al
T2465 654-708 Entity denotes the monofunctional alkylating agent temozolomide (TMZ)
T2400 673-689 Entity denotes alkylating agent
T2391 704-707 Entity denotes TMZ
T2456 791-794 Entity denotes TMZ
T2438 825-854 Entity denotes cancer stem cells, microRNAs,
T2373 855-859 Entity denotes drug
T2412 868-871 Entity denotes DNA
T2429 887-994 Entity denotes tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many
T2399 972-977 Protein denotes STAT3
T2405 972-984 Protein denotes STAT3 kinase
T2476 1142-1154 Entity denotes Temozolomide
T2377 1174-1189 Entity denotes of DNA lesions,
T2392 1200-1216 Entity denotes O6-methylguanine
T2378 1200-1216 Entity denotes O6-methylguanine
T2360 1218-1234 Entity denotes N3-methyladenine
T2444 1240-1256 Entity denotes N7-methylguanine
T2384 1240-1256 Entity denotes N7-methylguanine
T2481 1303-1330 Entity denotes The O6-methylguanine lesion
T2389 1303-1330 Entity denotes The O6-methylguanine lesion
T2498 1435-1483 Negative_regulation denotes inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
T2366 1446-1468 Protein denotes of antiapoptotic Bcl-2
T2464 1469-1483 Protein denotes by a pan-Bcl-2
T2428 1484-1497 Entity denotes inhibitor (−)
T2420 1484-1506 Entity denotes inhibitor (−)-gossypol
T2451 1568-1574 Entity denotes of TMZ
T2480 1638-1649 Entity denotes TMZ-induced
T2401 1717-1750 Entity denotes GBM cells (Knizhnik et al., 2013)
T2417 1758-1774 Protein denotes MAPO2 (C1orf201)
T2411 1758-1779 Protein denotes MAPO2 (C1orf201) gene
T2419 1765-1773 Protein denotes C1orf201
T2445 1800-1831 Entity denotes O6-methylguanine lesion-induced
T2364 1800-1831 Entity denotes O6-methylguanine lesion-induced
T2485 1867-1872 Protein denotes MAPO2
T2359 1867-1877 Protein denotes MAPO2 gene
T2500 1867-1908 Regulation denotes MAPO2 gene encodes a novel 37-kDa protein
T2474 1886-1908 Protein denotes a novel 37-kDa protein
T2381 1939-1948 Protein denotes this gene
T2461 1975-2002 Entity denotes The O6-methylguanine lesion
T2450 1975-2002 Entity denotes The O6-methylguanine lesion
T2468 2006-2084 Entity denotes a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT)
T2475 2036-2084 Protein denotes by O6-methylguanine-DNA methyltransferase (MGMT)
T2433 2079-2083 Protein denotes MGMT
T2385 2181-2185 Protein denotes MGMT
T2442 2194-2210 Entity denotes O6-methylguanine
T2439 2194-2210 Entity denotes O6-methylguanine
T2453 2267-2275 Protein denotes proteins
T2426 2292-2352 Protein denotes protein kinase that ultimately leads to apoptotic cell death
T2487 2402-2406 Protein denotes Roos
T2446 2410-2412 Entity denotes al
T2423 2441-2445 Protein denotes MGMT
T2431 2490-2493 Entity denotes TMZ
T2416 2529-2542 Entity denotes Pollack et al
T2452 2660-2663 Protein denotes MMR
T2421 2687-2690 Entity denotes TMZ
T2406 2747-2768 Entity denotes of MGMT gene promoter
T2395 2747-2768 Protein denotes of MGMT gene promoter
T2458 2750-2754 Protein denotes MGMT
T2477 2772-2777 Entity denotes cells
T2501 2832-2878 Positive_regulation denotes An increase in MGMT gene promoter methylation,
T2443 2844-2878 Protein denotes in MGMT gene promoter methylation,
T2437 2847-2851 Protein denotes MGMT
T2409 2857-2865 Entity denotes promoter
T2502 2879-2916 Negative_regulation denotes which blocks MGMT protein expression,
T2482 2892-2896 Protein denotes MGMT
T2388 2892-2904 Protein denotes MGMT protein
T2496 2892-2916 Gene_expression denotes MGMT protein expression,
T2494 2965-2990 Positive_regulation denotes overexpressed microRNA-21
T2493 2965-2990 Gene_expression denotes overexpressed microRNA-21
T2407 2965-2990 Protein denotes overexpressed microRNA-21
T2448 2999-3008 Protein denotes Bax/Bcl-2
T2435 2999-3008 Protein denotes Bax/Bcl-2
T2375 3003-3008 Protein denotes Bcl-2
T2370 3019-3028 Protein denotes caspase-3
T2397 3056-3067 Entity denotes TMZ-induced
T2403 3079-3082 Protein denotes Shi
T2449 3098-3109 Protein denotes MicroRNA-21
T2410 3153-3165 Entity denotes cancer cells
T2486 3185-3194 Entity denotes Integrins
T2386 3314-3317 Protein denotes p53
T2499 3314-3327 Positive_regulation denotes p53 signaling
T2390 3351-3362 Entity denotes glioma cell
T2372 3377-3406 Entity denotes TMZ (Janouskova et al., 2012)
T2368 3489-3520 Protein denotes The base excision repair enzyme
T2432 3573-3611 Entity denotes the cytotoxic lesions N3-methyladenine
T2371 3577-3586 Entity denotes cytotoxic
T2462 3616-3633 Entity denotes N7-methylguanine,
T2363 3616-3633 Entity denotes N7-methylguanine,
T2414 3659-3662 Entity denotes TMZ
T2492 3700-3810 Positive_regulation denotes Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
T2497 3713-3756 Binding denotes of mitochondrial respiratory chain coupling
T2490 3716-3747 Entity denotes mitochondrial respiratory chain
T2495 3757-3810 Negative_regulation denotes to suppress the production of reactive oxygen species
T2362 3812-3815 Protein denotes ROS
T2460 3827-3865 Protein denotes by cytochrome c oxidase contributes in
T2365 3843-3850 Protein denotes oxidase
T2467 3874-3877 Entity denotes TMZ
T2436 3934-3937 Entity denotes TMZ
T2473 3968-3972 Protein denotes MGMT
T2447 3968-3989 Entity denotes MGMT pseudosubstrates
T2376 3991-4007 Entity denotes O6-benzylguanine
T2472 4012-4023 Entity denotes lomeguatrib
T2394 4044-4050 Entity denotes to TMZ
T2379 4074-4118 Entity denotes Methoxyamine-blocker of base excision repair
T2425 4148-4151 Entity denotes TMZ
T2484 4183-4199 Entity denotes O6-methylguanine
T2418 4183-4199 Entity denotes O6-methylguanine
T2471 4183-4207 Entity denotes O6-methylguanine adducts
T2415 4186-4199 Entity denotes methylguanine
T2440 4323-4326 Entity denotes NAD
T2402 4355-4358 Entity denotes TMZ
T2367 4440-4461 Protein denotes Interferon-β (IFN-β),
T2478 4440-4475 Entity denotes Interferon-β (IFN-β), levetiracetam
T2361 4454-4459 Protein denotes IFN-β
T2483 4483-4495 Entity denotes resveratrol,
T2430 4500-4519 Entity denotes valproic acid (VAP)
T2470 4515-4518 Protein denotes VAP
T2469 4548-4551 Entity denotes TMZ
T2374 4560-4574 Protein denotes MGMT-dependent
T2427 4625-4659 Entity denotes Resveratrol, a natural polyphenol,
T2396 4638-4658 Entity denotes a natural polyphenol
T2404 4669-4672 Entity denotes TMZ
T2398 4691-4706 Protein denotes NF-κB-dependent
T2422 4739-4773 Protein denotes STAT3 inhibitor or STAT3 knockdown
T2441 4745-4754 Entity denotes inhibitor
T2454 4758-4763 Protein denotes STAT3
T2455 4786-4789 Entity denotes TMZ
T2489 4936-4939 Entity denotes TMZ
T2413 4997-5000 Entity denotes TMZ
T2424 5021-5024 Protein denotes Sun
T2383 5040-5057 Entity denotes Cancer stem cells
T2434 5093-5096 Entity denotes TMZ
T2382 5130-5139 Entity denotes stem cell
T2459 5169-5172 Entity denotes TMZ
T2491 5177-5205 Entity denotes other chemotherapeutic drugs
T2408 5297-5302 Protein denotes CD133
T2479 5303-5329 Entity denotes positive cancer stem cells
T2369 5352-5369 Entity denotes normal stem cells
T2393 5374-5391 Entity denotes cancer stem cells
T2457 5442-5450 Protein denotes of CD133
T2387 5467-5491 Entity denotes glioma cancer stem cells
T2380 5504-5527 Entity denotes its biological function
R1554 T2359 T2500 causeOf MAPO2 gene,MAPO2 gene encodes a novel 37-kDa protein
R1556 T2366 T2498 themeOf of antiapoptotic Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1562 T2386 T2499 causeOf p53,p53 signaling
R1563 T2388 T2496 themeOf MGMT protein,"MGMT protein expression,"
R1568 T2406 T2458 partOf of MGMT gene promoter,MGMT
R1569 T2407 T2493 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1570 T2407 T2494 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1571 T2464 T2498 causeOf by a pan-Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1572 T2474 T2500 themeOf a novel 37-kDa protein,MAPO2 gene encodes a novel 37-kDa protein
R1573 T2490 T2497 themeOf mitochondrial respiratory chain,of mitochondrial respiratory chain coupling
R1574 T2496 T2502 themeOf "MGMT protein expression,","which blocks MGMT protein expression,"
R1575 T2497 T2492 themeOf of mitochondrial respiratory chain coupling,Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species