bionlp-st-ge-2016-test-ihmc  

PMC:3586680 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Negation Speculation
T529 17-21 Protein denotes WWOX
T546 26-29 Protein denotes p53
T525 89-109 Protein denotes Tumor suppressor p53
T535 210-228 Entity denotes temozolomide (TMZ)
T523 224-227 Entity denotes TMZ
T526 233-250 Entity denotes therapeutic drugs
T537 252-287 Protein denotes WW domain-containing oxidoreductase
T532 252-292 Protein denotes WW domain-containing oxidoreductase WWOX
T534 301-305 Protein denotes WOX1
T541 310-332 Protein denotes a proapoptotic protein
T531 354-372 Protein denotes a tumor suppressor
T550 379-402 Gene_expression denotes of WWOX gene expression
T539 382-386 Protein denotes WWOX
T521 425-447 Entity denotes malignant cancer cells
T533 455-463 Entity denotes promoter
T549 545-581 Gene_expression denotes ectopic expression of wild type WWOX
T543 564-581 Protein denotes of wild type WWOX
T540 618-663 Entity denotes human glioblastoma cells harboring mutant p53
T527 653-663 Protein denotes mutant p53
T524 665-669 Protein denotes WWOX
T551 665-725 Binding denotes WWOX is known to physically bind and stabilize wild type p53
T547 665-725 Regulation denotes WWOX is known to physically bind and stabilize wild type p53
T520 712-725 Protein denotes wild type p53
T538 785-788 Protein denotes p53
T522 793-797 Protein denotes WWOX
T528 852-876 Protein denotes mutant p53, or isoforms,
T530 909-916 Protein denotes of WWOX
T545 945-949 Protein denotes WWOX
T548 945-960 Positive_regulation denotes WWOX activation
T542 964-981 Entity denotes therapeutic drugs
T536 988-991 Protein denotes p53
T544 1036-1039 Entity denotes TMZ
T2466 1255-1261 Entity denotes Silber
T2488 1425-1439 Entity denotes Friedman et al
T2463 1581-1591 Entity denotes Haar et al
T2465 1733-1787 Entity denotes the monofunctional alkylating agent temozolomide (TMZ)
T2400 1752-1768 Entity denotes alkylating agent
T2391 1783-1786 Entity denotes TMZ
T2456 1870-1873 Entity denotes TMZ
T2438 1904-1933 Entity denotes cancer stem cells, microRNAs,
T2373 1934-1938 Entity denotes drug
T2412 1947-1950 Entity denotes DNA
T2429 1966-2073 Entity denotes tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many
T2399 2051-2056 Protein denotes STAT3
T2405 2051-2063 Protein denotes STAT3 kinase
T2476 2221-2233 Entity denotes Temozolomide
T2377 2253-2268 Entity denotes of DNA lesions,
T2392 2279-2295 Entity denotes O6-methylguanine
T2378 2279-2295 Entity denotes O6-methylguanine
T2360 2297-2313 Entity denotes N3-methyladenine
T2444 2319-2335 Entity denotes N7-methylguanine
T2384 2319-2335 Entity denotes N7-methylguanine
T2481 2382-2409 Entity denotes The O6-methylguanine lesion
T2389 2382-2409 Entity denotes The O6-methylguanine lesion
T2498 2514-2562 Negative_regulation denotes inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
T2366 2525-2547 Protein denotes of antiapoptotic Bcl-2
T2464 2548-2562 Protein denotes by a pan-Bcl-2
T2428 2563-2576 Entity denotes inhibitor (−)
T2420 2563-2585 Entity denotes inhibitor (−)-gossypol
T2451 2647-2653 Entity denotes of TMZ
T2480 2717-2728 Entity denotes TMZ-induced
T2401 2796-2829 Entity denotes GBM cells (Knizhnik et al., 2013)
T2417 2837-2853 Protein denotes MAPO2 (C1orf201)
T2411 2837-2858 Protein denotes MAPO2 (C1orf201) gene
T2419 2844-2852 Protein denotes C1orf201
T2445 2879-2910 Entity denotes O6-methylguanine lesion-induced
T2364 2879-2910 Entity denotes O6-methylguanine lesion-induced
T2485 2946-2951 Protein denotes MAPO2
T2359 2946-2956 Protein denotes MAPO2 gene
T2500 2946-2987 Regulation denotes MAPO2 gene encodes a novel 37-kDa protein
T2474 2965-2987 Protein denotes a novel 37-kDa protein
T2381 3018-3027 Protein denotes this gene
T2461 3054-3081 Entity denotes The O6-methylguanine lesion
T2450 3054-3081 Entity denotes The O6-methylguanine lesion
T2468 3085-3163 Entity denotes a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT)
T2475 3115-3163 Protein denotes by O6-methylguanine-DNA methyltransferase (MGMT)
T2433 3158-3162 Protein denotes MGMT
T2385 3260-3264 Protein denotes MGMT
T2442 3273-3289 Entity denotes O6-methylguanine
T2439 3273-3289 Entity denotes O6-methylguanine
T2453 3346-3354 Protein denotes proteins
T2426 3371-3431 Protein denotes protein kinase that ultimately leads to apoptotic cell death
T2487 3481-3485 Protein denotes Roos
T2446 3489-3491 Entity denotes al
T2423 3520-3524 Protein denotes MGMT
T2431 3569-3572 Entity denotes TMZ
T2416 3608-3621 Entity denotes Pollack et al
T2452 3739-3742 Protein denotes MMR
T2421 3766-3769 Entity denotes TMZ
T2406 3826-3847 Entity denotes of MGMT gene promoter
T2395 3826-3847 Protein denotes of MGMT gene promoter
T2458 3829-3833 Protein denotes MGMT
T2477 3851-3856 Entity denotes cells
T2501 3911-3957 Positive_regulation denotes An increase in MGMT gene promoter methylation,
T2443 3923-3957 Protein denotes in MGMT gene promoter methylation,
T2437 3926-3930 Protein denotes MGMT
T2409 3936-3944 Entity denotes promoter
T2502 3958-3995 Negative_regulation denotes which blocks MGMT protein expression,
T2482 3971-3975 Protein denotes MGMT
T2388 3971-3983 Protein denotes MGMT protein
T2496 3971-3995 Gene_expression denotes MGMT protein expression,
T2494 4044-4069 Positive_regulation denotes overexpressed microRNA-21
T2493 4044-4069 Gene_expression denotes overexpressed microRNA-21
T2407 4044-4069 Protein denotes overexpressed microRNA-21
T2448 4078-4087 Protein denotes Bax/Bcl-2
T2435 4078-4087 Protein denotes Bax/Bcl-2
T2375 4082-4087 Protein denotes Bcl-2
T2370 4098-4107 Protein denotes caspase-3
T2397 4135-4146 Entity denotes TMZ-induced
T2403 4158-4161 Protein denotes Shi
T2449 4177-4188 Protein denotes MicroRNA-21
T2410 4232-4244 Entity denotes cancer cells
T2486 4264-4273 Entity denotes Integrins
T2386 4393-4396 Protein denotes p53
T2499 4393-4406 Positive_regulation denotes p53 signaling
T2390 4430-4441 Entity denotes glioma cell
T2372 4456-4485 Entity denotes TMZ (Janouskova et al., 2012)
T2368 4568-4599 Protein denotes The base excision repair enzyme
T2432 4652-4690 Entity denotes the cytotoxic lesions N3-methyladenine
T2371 4656-4665 Entity denotes cytotoxic
T2462 4695-4712 Entity denotes N7-methylguanine,
T2363 4695-4712 Entity denotes N7-methylguanine,
T2414 4738-4741 Entity denotes TMZ
T2492 4779-4889 Positive_regulation denotes Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
T2497 4792-4835 Binding denotes of mitochondrial respiratory chain coupling
T2490 4795-4826 Entity denotes mitochondrial respiratory chain
T2495 4836-4889 Negative_regulation denotes to suppress the production of reactive oxygen species
T2362 4891-4894 Protein denotes ROS
T2460 4906-4944 Protein denotes by cytochrome c oxidase contributes in
T2365 4922-4929 Protein denotes oxidase
T2467 4953-4956 Entity denotes TMZ
T2436 5013-5016 Entity denotes TMZ
T2473 5047-5051 Protein denotes MGMT
T2447 5047-5068 Entity denotes MGMT pseudosubstrates
T2376 5070-5086 Entity denotes O6-benzylguanine
T2472 5091-5102 Entity denotes lomeguatrib
T2394 5123-5129 Entity denotes to TMZ
T2379 5153-5197 Entity denotes Methoxyamine-blocker of base excision repair
T2425 5227-5230 Entity denotes TMZ
T2484 5262-5278 Entity denotes O6-methylguanine
T2418 5262-5278 Entity denotes O6-methylguanine
T2471 5262-5286 Entity denotes O6-methylguanine adducts
T2415 5265-5278 Entity denotes methylguanine
T2440 5402-5405 Entity denotes NAD
T2402 5434-5437 Entity denotes TMZ
T2367 5519-5540 Protein denotes Interferon-β (IFN-β),
T2478 5519-5554 Entity denotes Interferon-β (IFN-β), levetiracetam
T2361 5533-5538 Protein denotes IFN-β
T2483 5562-5574 Entity denotes resveratrol,
T2430 5579-5598 Entity denotes valproic acid (VAP)
T2470 5594-5597 Protein denotes VAP
T2469 5627-5630 Entity denotes TMZ
T2374 5639-5653 Protein denotes MGMT-dependent
T2427 5704-5738 Entity denotes Resveratrol, a natural polyphenol,
T2396 5717-5737 Entity denotes a natural polyphenol
T2404 5748-5751 Entity denotes TMZ
T2398 5770-5785 Protein denotes NF-κB-dependent
T2422 5818-5852 Protein denotes STAT3 inhibitor or STAT3 knockdown
T2441 5824-5833 Entity denotes inhibitor
T2454 5837-5842 Protein denotes STAT3
T2455 5865-5868 Entity denotes TMZ
T2489 6015-6018 Entity denotes TMZ
T2413 6076-6079 Entity denotes TMZ
T2424 6100-6103 Protein denotes Sun
T2383 6119-6136 Entity denotes Cancer stem cells
T2434 6172-6175 Entity denotes TMZ
T2382 6209-6218 Entity denotes stem cell
T2459 6248-6251 Entity denotes TMZ
T2491 6256-6284 Entity denotes other chemotherapeutic drugs
T2408 6376-6381 Protein denotes CD133
T2479 6382-6408 Entity denotes positive cancer stem cells
T2369 6431-6448 Entity denotes normal stem cells
T2393 6453-6470 Entity denotes cancer stem cells
T2457 6521-6529 Protein denotes of CD133
T2387 6546-6570 Entity denotes glioma cancer stem cells
T2380 6583-6606 Entity denotes its biological function
T5682 6686-6707 Protein denotes tumor suppressors p53
T5642 6712-6716 Protein denotes WWOX
T5676 6757-6775 Entity denotes glioblastoma cells
T5697 6799-6864 Protein denotes WW domain-containing oxidoreductase, known as WWOX, FOR, or WOX1,
T5630 6845-6855 Protein denotes WWOX, FOR,
T5620 6859-6863 Protein denotes WOX1
T5634 6888-6908 Protein denotes mouse WWOX/Wwox gene
T5635 6894-6903 Protein denotes WWOX/Wwox
T5675 6894-6903 Protein denotes WWOX/Wwox
T5738 6899-6903 Protein denotes Wwox
T5613 6910-6919 Protein denotes This gene
T5694 6934-6944 Entity denotes chromosome
T5653 7024-7028 Protein denotes WWOX
T5679 7024-7036 Protein denotes WWOX protein
T5731 7052-7066 Entity denotes two N-terminal
T5643 7052-7078 Entity denotes two N-terminal WW domains,
T5693 7079-7148 Entity denotes a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain
T5655 7081-7097 Entity denotes C-terminal short
T5702 7112-7141 Protein denotes dehydrogenase/reductase (SDR)
T5726 7137-7140 Protein denotes SDR
T5725 7154-7187 Entity denotes a proapoptotic C-terminal tail D3
T5626 7154-7187 Entity denotes a proapoptotic C-terminal tail D3
T5619 7254-7259 Entity denotes et al
T5709 7300-7304 Protein denotes WWOX
T5723 7331-7339 Protein denotes receptor
T5624 7344-7365 Entity denotes sex steroid hormones,
T5741 7348-7355 Entity denotes steroid
T5681 7372-7386 Entity denotes its SDR domain
T5646 7376-7379 Protein denotes SDR
T5703 7439-7447 Entity denotes androgen
T5717 7452-7460 Entity denotes estrogen
T13760 7533-7537 Protein denotes WWOX
T13720 7575-7579 Protein denotes WWOX
T13711 7589-7603 Entity denotes two N-terminal
T13751 7589-7628 Entity denotes two N-terminal WW domains, a C-terminal
T13694 7589-7628 Entity denotes two N-terminal WW domains, a C-terminal
T13754 7641-7686 Entity denotes alcohol dehydrogenase/reductase (SDR) domain,
T13732 7649-7678 Protein denotes dehydrogenase/reductase (SDR)
T13715 7674-7677 Protein denotes SDR
T13696 7693-7695 Entity denotes D3
T13698 7754-7768 Entity denotes the WW domains
T13707 7770-7781 Entity denotes Chang et al
T13728 7796-7810 Protein denotes Del Mare et al
T13712 7796-7810 Entity denotes Del Mare et al
T13702 7866-7880 Entity denotes The SDR domain
T13743 7870-7873 Protein denotes SDR
T13775 7936-7976 Binding denotes conserved tyrosine phosphorylation sites
T13722 7936-7976 Entity denotes conserved tyrosine phosphorylation sites
T13756 7946-7954 Entity denotes tyrosine
T13691 7978-7983 Entity denotes Tyr33
T13762 7988-7994 Entity denotes Tyr287
T13766 7996-8023 Entity denotes Other phosphorylation sites
T13723 8060-8064 Entity denotes Tyr6
T13733 8066-8071 Entity denotes Thr12
T13765 8073-8078 Entity denotes Ser14
T13692 8080-8085 Entity denotes Tyr61
T13726 8087-8093 Entity denotes Tyr293
T13706 8146-8150 Protein denotes WWOX
T13770 8146-8177 Phosphorylation denotes WWOX is phosphorylated in Tyr33
T13768 8146-8191 Binding denotes WWOX is phosphorylated in Tyr33 and binds p53
T13731 8172-8177 Entity denotes Tyr33
T13739 8188-8191 Protein denotes p53
T13688 8193-8213 Entity denotes The WWOX/p53 complex
T13701 8193-8213 Protein denotes The WWOX/p53 complex
T13721 8202-8205 Protein denotes p53
T13690 8235-8247 Entity denotes mitochondria
T13710 8251-8258 Entity denotes nucleus
T13736 8280-8284 Protein denotes WWOX
T13763 8296-8299 Protein denotes PPx
T13727 8296-8300 Entity denotes PPxY
T13717 8318-8373 Protein denotes transcription factors, such as RUNX2, c-Jun, and ERBB4,
T13695 8356-8362 Protein denotes c-Jun,
T13704 8367-8372 Protein denotes ERBB4
T13689 8378-8398 Entity denotes its first WW domain,
T13693 8435-8452 Protein denotes of these proteins
T13759 8474-8487 Entity denotes the cytoplasm
T13699 8489-8493 Protein denotes WWOX
T13773 8489-8522 Binding denotes WWOX binds Tau via its SDR domain
T13749 8500-8503 Protein denotes Tau
T13747 8508-8522 Entity denotes its SDR domain
T13761 8512-8515 Protein denotes SDR
T13718 8524-8528 Protein denotes WWOX
T13744 8545-8577 Protein denotes the Wnt/β-catenin signal pathway
T13730 8553-8562 Protein denotes β-catenin
T13771 8581-8592 Binding denotes binding Dvl
T13705 8589-8592 Protein denotes Dvl
T13746 8628-8635 Entity denotes Phorbol
T13755 8628-8641 Entity denotes Phorbol ester
T13767 8628-8706 Positive_regulation denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell
T13758 8670-8706 Entity denotes of MEK/WWOX complex in Jurkat T cell
T13740 8670-8706 Entity denotes of MEK/WWOX complex in Jurkat T cell
T13757 8677-8681 Protein denotes WWOX
T13748 8693-8706 Entity denotes Jurkat T cell
T13769 8712-8729 Regulation denotes the released WWOX
T13700 8712-8729 Protein denotes the released WWOX
T13752 8746-8785 Entity denotes the mitochondria for causing cell death
T13735 8787-8791 Protein denotes WWOX
T13697 8812-8820 Entity denotes membrane
T13772 8829-8870 Binding denotes association with Hyal-2 and phospho-Ezrin
T13703 8846-8852 Protein denotes Hyal-2
T13753 8857-8870 Protein denotes phospho-Ezrin
T13741 8872-8878 Protein denotes Hyal-2
T13745 8897-8905 Protein denotes receptor
T13742 8910-8916 Protein denotes TGF-β1
T13719 8933-8979 Protein denotes TGF-β1, WWOX binds Hyal-2 and forms a complex,
T13714 8941-8945 Protein denotes WWOX
T13774 8941-8958 Binding denotes WWOX binds Hyal-2
T13737 8952-8958 Protein denotes Hyal-2
T13709 8969-8978 Entity denotes a complex
T13708 9006-9017 Entity denotes the nucleus
T13724 9048-9056 Entity denotes promoter
T13713 9067-9072 Protein denotes Ack1,
T13750 9067-9150 Protein denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI,
T13725 9067-9150 Protein denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI,
T13734 9118-9149 Protein denotes hyaluronoglucosaminidase 2; CKI
T13687 9151-9157 Protein denotes casein
T13764 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13738 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13729 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13716 9197-9218 Protein denotes PKA, protein kinase A
T5685 9638-9662 Protein denotes Restoration of WWOX gene
T5618 9650-9657 Protein denotes of WWOX
T5637 9815-9832 Entity denotes WW domain of WWOX
T5759 9815-9859 Binding denotes WW domain of WWOX may interact with proteins true
T5654 9828-9832 Protein denotes WWOX
T5739 9846-9859 Protein denotes with proteins
T5706 9873-9876 Protein denotes PPx
T5671 9876-9877 Entity denotes Y
T5708 9895-9901 Protein denotes AP-2γ,
T5688 9895-9942 Protein denotes AP-2γ, p73, ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4,
T5744 9907-9935 Protein denotes ErbB4, Ezrin, SIMPLE, c-Jun,
T5664 9907-9941 Protein denotes ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4
T5689 9914-9928 Protein denotes Ezrin, SIMPLE,
T5704 9914-9934 Protein denotes Ezrin, SIMPLE, c-Jun
T5657 9921-9927 Protein denotes SIMPLE
T5767 10028-10058 Gene_expression denotes Transiently overexpressed WWOX
T5766 10028-10058 Positive_regulation denotes Transiently overexpressed WWOX
T5677 10028-10058 Protein denotes Transiently overexpressed WWOX
T5768 10028-10107 Binding denotes Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun
T5690 10065-10107 Protein denotes transcription factors AP-2, p73, and c-Jun
T5734 10087-10091 Protein denotes AP-2
T5724 10093-10096 Protein denotes p73
T5692 10102-10107 Protein denotes c-Jun
T5727 10170-10190 Entity denotes cancer cell survival
T5743 10232-10236 Protein denotes Wwox
T5711 10309-10319 Entity denotes the nuclei
T5662 10323-10330 Entity denotes neurons
T5754 10385-10473 Negative_regulation denotes No blocking of translocation of transcription factors to the nuclei by Wwox was observed
T5712 10442-10452 Entity denotes the nuclei
T5730 10453-10460 Protein denotes by Wwox
T5742 10500-10504 Protein denotes WWOX
T5748 10500-10583 Binding denotes WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of
T5623 10541-10547 Entity denotes Tyr33,
T5720 10558-10566 Protein denotes proteins
T5770 10648-10662 Positive_regulation denotes Activated WWOX
T5622 10648-10662 Protein denotes Activated WWOX
T5765 10648-10729 Binding denotes Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1),
T5752 10684-10729 Phosphorylation denotes with serine 46-phosphorylated p53 (Figure 1),
T5701 10684-10729 Protein denotes with serine 46-phosphorylated p53 (Figure 1),
T5672 10689-10713 Entity denotes serine 46-phosphorylated
T5666 10747-10750 Protein denotes p53
T5614 10807-10811 Protein denotes WWOX
T5762 10807-10844 Binding denotes WWOX binds Disheveled proteins (Dvl),
T5713 10818-10844 Protein denotes Disheveled proteins (Dvl),
T5625 10839-10842 Protein denotes Dvl
T5710 10873-10915 Protein denotes Wnt/β-catenin signaling pathway (Figure 1)
T5633 10877-10886 Protein denotes β-catenin
T5629 10937-10940 Protein denotes Dvl
T5756 10954-10972 Positive_regulation denotes overexpressed WWOX
T5755 10954-10972 Gene_expression denotes overexpressed WWOX
T5663 10954-10972 Protein denotes overexpressed WWOX
T5751 10954-11040 Regulation denotes overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
T5638 10984-10989 Protein denotes Dvl-2
T5732 10993-11006 Entity denotes the cytoplasm
T5661 11026-11040 Protein denotes Dvl-2-mediated
T5750 11096-11114 Positive_regulation denotes Overexpressed WWOX
T5749 11096-11114 Gene_expression denotes Overexpressed WWOX
T5680 11096-11114 Protein denotes Overexpressed WWOX
T5729 11160-11192 Entity denotes of human hepatic carcinoma cells
T5650 11215-11237 Entity denotes many cancer cell types
T5678 11303-11307 Protein denotes WWOX
T5670 11317-11364 Entity denotes the cytotoxic function of tumor necrosis factor
T5718 11340-11364 Protein denotes of tumor necrosis factor
T5747 11368-11420 Negative_regulation denotes down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
T5746 11368-11420 Negative_regulation denotes down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
T5645 11384-11403 Entity denotes apoptosis inhibitor
T5686 11384-11409 Protein denotes apoptosis inhibitor Bcl-2
T5665 11414-11420 Protein denotes Bcl-xL
T5621 11439-11452 Protein denotes apoptotic p53
T5715 11481-11485 Protein denotes WWOX
T5674 11527-11530 Protein denotes p53
T5640 11549-11558 Entity denotes chemicals
T5636 11611-11634 Entity denotes chemotherapeutic drugs,
T5740 11635-11639 Protein denotes WWOX
T5615 11669-11674 Entity denotes Tyr33
T5721 11688-11701 Entity denotes others sites,
T5617 11728-11740 Entity denotes mitochondria
T5667 11744-11750 Entity denotes nuclei
T5649 11802-11806 Protein denotes WWOX
T5764 11802-11852 Binding denotes WWOX binds MEK in Jurkat T cells (Lin et al., 2011
T5641 11813-11816 Entity denotes MEK
T5722 11820-11847 Entity denotes Jurkat T cells (Lin et al.,
T5736 11836-11839 Entity denotes Lin
T5691 11836-11845 Entity denotes Lin et al
T5651 11855-11862 Entity denotes Phorbol
T5733 11855-11886 Entity denotes Phorbol myristate acetate (PMA)
T5687 11855-11886 Entity denotes Phorbol myristate acetate (PMA)
T5656 11882-11885 Entity denotes PMA
T5735 11899-11919 Entity denotes the MEK/WWOX complex
T5628 11899-11919 Entity denotes the MEK/WWOX complex
T5705 11907-11911 Protein denotes WWOX
T5683 11932-11936 Protein denotes WWOX
T5669 11955-11971 Entity denotes the mitochondria
T5716 12001-12004 Entity denotes MEK
T5707 12022-12027 Entity denotes lipid
T5763 12034-12060 Negative_regulation denotes Inhibition of MEK activity
T5673 12048-12051 Entity denotes MEK
T5696 12071-12082 Entity denotes TMZ-induced
T5761 12146-12178 Gene_expression denotes expression of WWOX in A549 cells
T5728 12157-12164 Protein denotes of WWOX
T5616 12187-12199 Protein denotes procaspase-3
T5737 12204-12216 Protein denotes procaspase-9
T5753 12204-12227 Positive_regulation denotes procaspase-9 activation
T5700 12240-12252 Entity denotes cytochrome C
T5699 12268-12284 Entity denotes the mitochondria
T5758 12331-12359 Phosphorylation denotes ectopic WWOX phosphorylation
T5668 12339-12343 Protein denotes WWOX
T5632 12382-12386 Entity denotes cell
T5660 12489-12496 Protein denotes of WWOX
T5631 12512-12542 Entity denotes the membrane/cytoskeleton area
T5760 12547-12580 Binding denotes binding with hyaluronidase Hyal-2
T5658 12555-12580 Protein denotes with hyaluronidase Hyal-2
T5698 12560-12573 Protein denotes hyaluronidase
T5627 12604-12617 Protein denotes Phospho-Ezrin
T5647 12604-12617 Protein denotes Phospho-Ezrin
T5719 12638-12667 Protein denotes Transforming growth factor β1
T5757 12638-12685 Binding denotes Transforming growth factor β1 binds Hyal-2 as a
T5695 12674-12680 Protein denotes Hyal-2
T5639 12686-12702 Protein denotes cognate receptor
T5769 12713-12834 Gene_expression denotes the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity
T5652 12734-12738 Protein denotes WWOX
T5684 12734-12751 Protein denotes WWOX/Hyal-2/Smad4
T5644 12734-12751 Protein denotes WWOX/Hyal-2/Smad4
T5648 12739-12745 Protein denotes Hyal-2
T5714 12775-12786 Entity denotes the nucleus
T5745 12791-12834 Positive_regulation denotes enhancing the SMAD-driven promoter activity
T5659 12817-12825 Entity denotes promoter
T7373 12874-12887 Positive_regulation denotes Activated p53
T7354 12874-12887 Protein denotes Activated p53
T7365 12927-12937 Protein denotes senescence
T7356 13016-13019 Protein denotes p53
T7370 13062-13065 Protein denotes p53
T7371 13095-13162 Positive_regulation denotes transactivating genes such as cyclin-dependent kinase inhibitor p21
T7369 13111-13124 Protein denotes genes such as
T7366 13111-13162 Protein denotes genes such as cyclin-dependent kinase inhibitor p21
T7359 13176-13181 Protein denotes miR34
T7363 13183-13186 Protein denotes p53
T7372 13208-13278 Positive_regulation denotes transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,
T7355 13224-13250 Protein denotes proapoptotic genes such as
T7350 13224-13278 Protein denotes proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,
T7353 13256-13260 Protein denotes PUMA
T7362 13262-13268 Protein denotes SCOTIN
T7357 13274-13277 Protein denotes FAS
T7375 13283-13322 Negative_regulation denotes inhibiting the antiapoptotic gene BCL-2
T7360 13294-13322 Protein denotes the antiapoptotic gene BCL-2
T7358 13294-13322 Protein denotes the antiapoptotic gene BCL-2
T7352 13348-13351 Protein denotes p53
T7351 13398-13423 Entity denotes depending upon cell types
T7349 13526-13529 Protein denotes p53
T7374 13576-13626 Regulation denotes regulating the expression of smooth muscle α-actin
T7367 13605-13626 Protein denotes smooth muscle α-actin
T7361 13649-13663 Protein denotes collagens IIα1
T7364 13668-13672 Protein denotes VIα1
T7368 13674-13677 Protein denotes Sun
T14783 13720-13723 Protein denotes p53
T14778 13728-13754 Protein denotes WWOX in GBM cell apoptosis
T14750 13736-13754 Entity denotes GBM cell apoptosis
T14768 13760-13775 Protein denotes Full-length p53
T14761 13760-13775 Protein denotes Full-length p53
T14779 13786-13855 Entity denotes two N-terminal transactivation acidic domains, a proline-rich domain,
T14746 13786-13855 Entity denotes two N-terminal transactivation acidic domains, a proline-rich domain,
T14742 13833-13854 Entity denotes a proline-rich domain
T14744 13835-13847 Protein denotes proline-rich
T14780 13890-13909 Entity denotes a C-terminal domain
T14764 13890-13909 Entity denotes a C-terminal domain
T14752 13953-13978 Entity denotes an oligomerization domain
T14745 13953-13978 Protein denotes an oligomerization domain
T14755 14000-14034 Entity denotes N-terminal deletion mutants of p53
T14772 14031-14034 Protein denotes p53
T14743 14095-14099 Protein denotes WWOX
T14767 14104-14107 Protein denotes p53
T14762 14143-14155 Protein denotes ectopic WWOX
T14786 14185-14230 Gene_expression denotes GBM cells expressing endogenous wild type p53
T14769 14185-14230 Entity denotes GBM cells expressing endogenous wild type p53
T14766 14206-14230 Protein denotes endogenous wild type p53
T14754 14248-14260 Protein denotes ectopic WWOX
T14785 14248-14266 Binding denotes ectopic WWOX binds
T14782 14296-14299 Protein denotes p53
T14771 14305-14318 Protein denotes both proteins
T14748 14413-14432 Protein denotes mutant p53 proteins
T14747 14420-14423 Protein denotes p53
T14751 14437-14441 Protein denotes WWOX
T14774 14458-14467 Entity denotes GBM cells
T14765 14469-14487 Protein denotes Thus, ectopic WWOX
T14763 14515-14518 Protein denotes p53
T14777 14554-14558 Protein denotes WWOX
T14784 14554-14564 Binding denotes WWOX binds
T14753 14565-14577 Protein denotes p53 isoforms
T14776 14612-14616 Protein denotes WWOX
T14760 14643-14676 Entity denotes GBM cells expressing p53 isoforms
T14758 14664-14667 Protein denotes p53
T14781 14704-14708 Entity denotes TAD,
T14775 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14757 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14749 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14773 14733-14737 Protein denotes PrD,
T14770 14792-14832 Protein denotes oligomerization domain; BR, basic region
T14756 14792-14832 Entity denotes oligomerization domain; BR, basic region
T14759 14816-14819 Protein denotes BR,
T8236 14874-14877 Protein denotes p53
T8254 14906-14957 Binding denotes alternative mRNA splicing, multiple gene promoters,
T8216 14918-14922 Protein denotes mRNA
T8241 14933-14956 Entity denotes multiple gene promoters
T8218 14933-14956 Protein denotes multiple gene promoters
T8244 15027-15030 Protein denotes Ray
T8243 15088-15103 Protein denotes of p53 isoforms
T8237 15161-15176 Protein denotes Full-length p53
T8221 15161-15176 Protein denotes Full-length p53
T8223 15178-15185 Protein denotes Δ133p53
T8239 15191-15195 Protein denotes p53β
T8235 15220-15232 Entity denotes the nucleus,
T8230 15261-15270 Entity denotes cytoplasm
T8233 15272-15276 Protein denotes p53γ
T8258 15272-15332 Localization denotes p53γ and Δ133p53β are localized in the nucleus and cytoplasm
T8257 15272-15332 Localization denotes p53γ and Δ133p53β are localized in the nucleus and cytoplasm
T8238 15281-15289 Protein denotes Δ133p53β
T8234 15307-15318 Entity denotes the nucleus
T8215 15323-15332 Entity denotes cytoplasm
T8255 15334-15395 Localization denotes Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)
T8222 15334-15395 Protein denotes Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)
T8240 15356-15395 Entity denotes in the cytoplasm (Bourdon et al., 2005)
T8229 15416-15419 Protein denotes p53
T8246 15424-15428 Protein denotes p53β
T8242 15439-15451 Protein denotes p53-mediated
T8259 15471-15504 Gene_expression denotes co-expression of p53 with Δ133p53
T8248 15471-15515 Negative_regulation denotes co-expression of p53 with Δ133p53 suppresses
T8247 15485-15491 Protein denotes of p53
T8220 15497-15504 Protein denotes Δ133p53
T8225 15516-15519 Protein denotes p53
T8228 15563-15570 Protein denotes Δ133p53
T8249 15563-15645 Regulation denotes Δ133p53 differentially regulates gene expression in p53-dependent and -independent
T8256 15596-15628 Regulation denotes gene expression in p53-dependent
T8245 15615-15628 Protein denotes p53-dependent
T8253 15678-15724 Gene_expression denotes Co-expression of Δ133p53β or Δ133p53γ with p53
T8252 15678-15724 Gene_expression denotes Co-expression of Δ133p53β or Δ133p53γ with p53
T8251 15678-15760 Regulation denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional true
T8250 15678-15760 Regulation denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional true
T8226 15695-15703 Protein denotes Δ133p53β
T8217 15707-15715 Protein denotes Δ133p53γ
T8231 15721-15724 Protein denotes p53
T8224 15741-15744 Protein denotes p53
T8227 15773-15776 Protein denotes p21
T8219 15781-15784 Protein denotes Bax
T8232 15781-15794 Entity denotes Bax promoters
T9128 15852-15863 Protein denotes p53 mutants
T9156 15944-15947 Entity denotes TMZ
T9162 15961-15973 Entity denotes glioma cells
T9155 16004-16009 Entity denotes et al
T9161 16028-16033 Entity denotes et al
T9158 16064-16086 Protein denotes Loss of functional p53
T9141 16110-16113 Entity denotes TMZ
T9157 16117-16129 Entity denotes glioma cells
T9170 16139-16152 Protein denotes wild type p53
T9148 16167-16170 Entity denotes TMZ
T9143 16205-16216 Protein denotes p53 mutants
T9160 16224-16227 Entity denotes TMZ
T9177 16274-16297 Gene_expression denotes Altered WWOX expression
T9171 16274-16297 Regulation denotes Altered WWOX expression
T9153 16282-16286 Protein denotes WWOX
T9175 16325-16347 Negative_regulation denotes downregulation of WWOX
T9124 16340-16347 Protein denotes of WWOX
T9154 16394-16402 Entity denotes promoter
T9174 16468-16486 Positive_regulation denotes overexpressed WWOX
T9173 16468-16486 Gene_expression denotes overexpressed WWOX
T9169 16468-16486 Protein denotes overexpressed WWOX
T9147 16508-16534 Entity denotes glioblastoma U373-MG cells
T9125 16508-16534 Entity denotes glioblastoma U373-MG cells
T9142 16545-16555 Protein denotes mutant p53
T9137 16582-16585 Entity denotes DNA
T9164 16632-16644 Protein denotes ectopic WWOX
T9145 16664-16695 Entity denotes U87-MG expressing wild type p53
T9144 16682-16695 Protein denotes wild type p53
T9139 16704-16708 Entity denotes TMZ,
T9123 16709-16713 Protein denotes WWOX
T9159 16753-16779 Entity denotes a mitochondria-independent
T9151 16784-16805 Protein denotes caspase-3-independent
T9138 16927-16954 Entity denotes of human glioblastoma cells
T9132 17013-17024 Protein denotes p53 mutants
T9150 17029-17033 Protein denotes WWOX
T9179 17035-17049 Positive_regulation denotes Activated WWOX
T9166 17035-17049 Protein denotes Activated WWOX
T9172 17035-17096 Binding denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation
T9168 17056-17069 Protein denotes wild type p53
T9163 17075-17080 Entity denotes Ser46
T9136 17191-17199 Entity denotes of Ser46
T9149 17203-17209 Protein denotes Δ40p53
T9176 17211-17244 Binding denotes binding of this protein with WWOX
T9135 17219-17244 Protein denotes of this protein with WWOX
T9165 17240-17244 Protein denotes WWOX
T9152 17292-17302 Entity denotes GBM cells,
T9133 17308-17321 Protein denotes wild type p53
T9146 17326-17347 Protein denotes ectopic WWOX proteins
T9134 17334-17338 Protein denotes WWOX
T9126 17463-17482 Protein denotes Mutant p53 proteins
T9178 17463-17520 Binding denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells true
T9131 17470-17473 Protein denotes p53
T9167 17495-17507 Protein denotes ectopic WWOX
T9127 17511-17520 Entity denotes GBM cells
T9130 17526-17530 Protein denotes WWOX
T9129 17568-17572 Protein denotes WWOX
T9140 17608-17611 Protein denotes p53
T11584 17685-17689 Protein denotes WWOX
T11541 17698-17701 Entity denotes TMZ
T11531 17741-17766 Protein denotes Binding proteins for WWOX
T11569 17762-17766 Protein denotes WWOX
T11589 17774-17777 Protein denotes p53
T11539 17813-17816 Entity denotes TMZ
T11570 17832-17841 Entity denotes GBM cells
T11527 17843-17847 Protein denotes WWOX
T11595 17843-17858 Binding denotes WWOX binds MEK,
T11550 17854-17858 Entity denotes MEK,
T11571 17863-17871 Entity denotes that PMA
T11489 17884-17896 Entity denotes this complex
T11529 17922-17938 Entity denotes T leukemia cells
T11500 17940-17943 Entity denotes Lin
T11505 17959-18005 Entity denotes Thus, appropriate chemicals, which break apart
T11530 18006-18026 Entity denotes the WWOX/MEK complex
T11493 18006-18026 Protein denotes the WWOX/MEK complex
T11573 18015-18018 Entity denotes MEK
T11564 18108-18117 Entity denotes chemicals
T11479 18123-18207 Entity denotes selected certain small molecules that induce apoptosis of many types of cancer cells
T11575 18192-18207 Entity denotes of cancer cells
T11557 18262-18268 Entity denotes of MEK
T11567 18269-18283 Entity denotes by selumetinib
T11499 18465-18505 Entity denotes prostate cancer and neuroblastomas cells
T11537 18528-18550 Protein denotes of downstream proteins
T11596 18608-18671 Positive_regulation denotes In this event, ectopic WWOX is activated for inducing apoptosis
T11581 18623-18635 Protein denotes ectopic WWOX
T11551 18681-18696 Protein denotes of ectopic WWOX
T11572 18722-18734 Entity denotes glioma cells
T11556 18746-18759 Protein denotes wild type p53
T11598 18794-18864 Binding denotes In most cases, we have shown that p53 functionally interacts with WWOX
T11553 18828-18831 Protein denotes p53
T11510 18855-18864 Protein denotes with WWOX
T11524 18870-18883 Protein denotes both proteins
T11525 18926-18937 Entity denotes Chang et al
T11549 19018-19034 Protein denotes that p53-binding
T11509 19035-19070 Protein denotes proteins, which are present in GBMs
T11497 19117-19121 Protein denotes WWOX
T11483 19126-19129 Protein denotes p53
T11544 19265-19320 Protein denotes many tumor suppressor proteins, e.g., p53, WWOX, Smad4,
T11521 19303-19313 Protein denotes p53, WWOX,
T11501 19303-19319 Protein denotes p53, WWOX, Smad4
T11506 19308-19312 Protein denotes WWOX
T11511 19321-19341 Protein denotes PTEN, PP2A, and etc.
T11533 19419-19428 Entity denotes Lai et al
T11577 19474-19482 Protein denotes proteins
T11535 19646-19661 Protein denotes endogenous WWOX
T11515 19695-19709 Protein denotes endogenous p53
T11520 19865-19930 Entity denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy,
T11542 19892-19896 Protein denotes PI3K
T11498 19898-19901 Protein denotes Akt
T11534 19903-19907 Protein denotes mTOR
T11578 19909-19914 Protein denotes NF-κB
T11547 19954-19975 Entity denotes these migrating cells
T11552 20029-20041 Entity denotes Glioma cells
T11508 20050-20054 Protein denotes CD44
T11518 20058-20095 Protein denotes a receptor for interacting with brain
T11532 20096-20128 Entity denotes matrix hyaluronan (Murai et al.,
T11507 20115-20126 Entity denotes Murai et al
T11522 20170-20184 Entity denotes hyaluronidases
T11586 20189-20207 Protein denotes metalloproteinases
T11491 20239-20252 Entity denotes Delpech et al
T11592 20317-20335 Gene_expression denotes of WWOX expression
T11559 20320-20324 Protein denotes WWOX
T11574 20393-20400 Protein denotes of WWOX
T11588 20445-20463 Entity denotes osteosarcoma cells
T11526 20487-20498 Protein denotes Del Mare et
T11591 20511-20538 Gene_expression denotes Ectopic expression of TIAF1
T11580 20530-20538 Protein denotes of TIAF1
T11590 20540-20553 Protein denotes TGF-β-induced
T11486 20577-20581 Protein denotes p53,
T11512 20586-20590 Protein denotes WWOX
T11583 20674-20686 Entity denotes cancer cells
T11566 20725-20770 Entity denotes glioma cells, with stem cell-like properties,
T11523 20744-20753 Entity denotes stem cell
T11546 20870-20930 Entity denotes mouse Wwox gene knockout cells (e.g., embryonic fibroblasts)
T11517 20876-20880 Protein denotes Wwox
T11587 20881-20885 Protein denotes gene
T11502 20908-20929 Entity denotes embryonic fibroblasts
T11548 20983-20998 Entity denotes wild type cells
T11495 21064-21071 Protein denotes of WWOX
T11560 21087-21118 Entity denotes the cell membrane/cytoskeleton,
T11528 21087-21118 Entity denotes the cell membrane/cytoskeleton,
T11490 21119-21123 Protein denotes WWOX
T11555 21124-21138 Entity denotes negative cells
T11585 21159-21187 Protein denotes parental WWOX-positive cells
T11563 21224-21228 Protein denotes WWOX
T11488 21229-21243 Entity denotes negative cells
T11504 21262-21285 Entity denotes the WWOX-positive cells
T11519 21266-21270 Protein denotes WWOX
T11568 21300-21304 Protein denotes WWOX
T11481 21305-21326 Entity denotes negative glioma cells
T11482 21367-21371 Protein denotes WWOX
T11496 21372-21394 Entity denotes expressing brain cells
T11593 21398-21423 Gene_expression denotes low WWOX expression areas
T11540 21402-21406 Protein denotes WWOX
T11576 21463-21467 Protein denotes WWOX
T11480 21468-21489 Entity denotes negative glioma cells
T11485 21622-21626 Protein denotes Wwox
T11561 21622-21641 Protein denotes Wwox knockout mice,
T11579 21756-21767 Protein denotes Del Mare et
T11516 21823-21827 Protein denotes Wwox
T11597 21918-21935 Gene_expression denotes generation of ROS
T11536 21929-21935 Protein denotes of ROS
T11582 21988-21992 Protein denotes Wwox
T11562 22017-22045 Protein denotes ROS production in Drosophila
T11503 22047-22059 Entity denotes Cancer cells
T11494 22181-22185 Protein denotes WWOX
T11545 22208-22227 Entity denotes glucose consumption
T11554 22231-22243 Entity denotes cancer cells
T11594 22255-22316 Gene_expression denotes generation of ROS to curb the cancer cell growth and invasion
T11487 22266-22272 Protein denotes of ROS
T11565 22398-22419 Protein denotes tumor suppressors p53
T11492 22424-22428 Protein denotes WWOX
T11513 22443-22446 Entity denotes TMZ
T11514 22462-22471 Entity denotes GBM cells
T11543 22496-22503 Protein denotes of WWOX
T11484 22590-22594 Protein denotes WWOX
T11558 22610-22613 Entity denotes TMZ
T11538 22628-22640 Entity denotes cancer cells
T12539 22721-22729 Entity denotes with TMZ
T12538 22773-22776 Protein denotes p53
T12537 22781-22785 Protein denotes WWOX
R10155 T14754 T14785 themeOf ectopic WWOX,ectopic WWOX binds
R10156 T14766 T14786 themeOf endogenous wild type p53,GBM cells expressing endogenous wild type p53
R10157 T14777 T14784 themeOf WWOX,WWOX binds
R1554 T2359 T2500 causeOf MAPO2 gene,MAPO2 gene encodes a novel 37-kDa protein
R1556 T2366 T2498 themeOf of antiapoptotic Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1562 T2386 T2499 causeOf p53,p53 signaling
R1563 T2388 T2496 themeOf MGMT protein,"MGMT protein expression,"
R1568 T2406 T2458 partOf of MGMT gene promoter,MGMT
R1569 T2407 T2493 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1570 T2407 T2494 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1571 T2464 T2498 causeOf by a pan-Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1572 T2474 T2500 themeOf a novel 37-kDa protein,MAPO2 gene encodes a novel 37-kDa protein
R1573 T2490 T2497 themeOf mitochondrial respiratory chain,of mitochondrial respiratory chain coupling
R1574 T2496 T2502 themeOf "MGMT protein expression,","which blocks MGMT protein expression,"
R1575 T2497 T2492 themeOf of mitochondrial respiratory chain coupling,Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
R259 T520 T547 themeOf wild type p53,WWOX is known to physically bind and stabilize wild type p53
R260 T524 T547 causeOf WWOX,WWOX is known to physically bind and stabilize wild type p53
R261 T524 T551 themeOf WWOX,WWOX is known to physically bind and stabilize wild type p53
R262 T539 T550 themeOf WWOX,of WWOX gene expression
R263 T543 T549 themeOf of wild type WWOX,ectopic expression of wild type WWOX
R264 T545 T548 themeOf WWOX,WWOX activation
R3832 T5614 T5762 themeOf WWOX,"WWOX binds Disheveled proteins (Dvl),"
R3834 T5622 T5770 themeOf Activated WWOX,Activated WWOX
R3842 T5637 T5759 themeOf WW domain of WWOX,WW domain of WWOX may interact with proteins
R3844 T5641 T5764 themeOf MEK,"WWOX binds MEK in Jurkat T cells (Lin et al., 2011"
R3847 T5649 T5764 themeOf WWOX,"WWOX binds MEK in Jurkat T cells (Lin et al., 2011"
R3852 T5658 T5760 themeOf with hyaluronidase Hyal-2,binding with hyaluronidase Hyal-2
R3855 T5661 T5751 causeOf Dvl-2-mediated,overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
R3858 T5663 T5751 themeOf overexpressed WWOX,overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
R3859 T5663 T5755 themeOf overexpressed WWOX,overexpressed WWOX
R3860 T5663 T5756 themeOf overexpressed WWOX,overexpressed WWOX
R3861 T5665 T5747 themeOf Bcl-xL,down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
R3862 T5668 T5758 themeOf WWOX,ectopic WWOX phosphorylation
R3863 T5672 T5701 partOf serine 46-phosphorylated,"with serine 46-phosphorylated p53 (Figure 1),"
R3864 T5672 T5752 siteOf serine 46-phosphorylated,"with serine 46-phosphorylated p53 (Figure 1),"
R3867 T5677 T5766 themeOf Transiently overexpressed WWOX,Transiently overexpressed WWOX
R3868 T5677 T5767 themeOf Transiently overexpressed WWOX,Transiently overexpressed WWOX
R3869 T5677 T5768 themeOf Transiently overexpressed WWOX,"Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun"
R3870 T5680 T5749 themeOf Overexpressed WWOX,Overexpressed WWOX
R3871 T5680 T5750 themeOf Overexpressed WWOX,Overexpressed WWOX
R3873 T5684 T5769 themeOf WWOX/Hyal-2/Smad4,the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity
R3875 T5686 T5746 themeOf apoptosis inhibitor Bcl-2,down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
R3877 T5690 T5768 themeOf "transcription factors AP-2, p73, and c-Jun","Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun"
R3881 T5695 T5757 themeOf Hyal-2,Transforming growth factor β1 binds Hyal-2 as a
R3883 T5701 T5752 themeOf "with serine 46-phosphorylated p53 (Figure 1),","with serine 46-phosphorylated p53 (Figure 1),"
R3884 T5701 T5765 themeOf "with serine 46-phosphorylated p53 (Figure 1),","Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1),"
R3885 T5737 T5753 themeOf procaspase-9,procaspase-9 activation
R3886 T5739 T5759 themeOf with proteins,WW domain of WWOX may interact with proteins
R3887 T5713 T5762 themeOf "Disheveled proteins (Dvl),","WWOX binds Disheveled proteins (Dvl),"
R3888 T5742 T5748 themeOf WWOX,"WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of"
R3889 T5719 T5757 themeOf Transforming growth factor β1,Transforming growth factor β1 binds Hyal-2 as a
R3891 T5720 T5748 themeOf proteins,"WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of"
R3892 T5728 T5761 themeOf of WWOX,expression of WWOX in A549 cells
R3893 T5730 T5754 causeOf by Wwox,No blocking of translocation of transcription factors to the nuclei by Wwox was observed
R5189 T7350 T7372 themeOf "proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,","transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,"
R5190 T7354 T7373 themeOf Activated p53,Activated p53
R5191 T7360 T7375 themeOf the antiapoptotic gene BCL-2,inhibiting the antiapoptotic gene BCL-2
R5192 T7366 T7371 themeOf genes such as cyclin-dependent kinase inhibitor p21,transactivating genes such as cyclin-dependent kinase inhibitor p21
R5740 T8215 T8257 locationOf cytoplasm,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5741 T8215 T8258 locationOf cytoplasm,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5742 T8216 T8254 themeOf mRNA,"alternative mRNA splicing, multiple gene promoters,"
R5743 T8217 T8252 themeOf Δ133p53γ,Co-expression of Δ133p53β or Δ133p53γ with p53
R5744 T8222 T8255 themeOf "Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)","Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)"
R5745 T8224 T8250 themeOf p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5746 T8224 T8251 themeOf p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5747 T8226 T8253 themeOf Δ133p53β,Co-expression of Δ133p53β or Δ133p53γ with p53
R5748 T8228 T8249 causeOf Δ133p53,Δ133p53 differentially regulates gene expression in p53-dependent and -independent
R5749 T8232 T8219 partOf Bax promoters,Bax
R5750 T8233 T8258 themeOf p53γ,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5751 T8234 T8257 locationOf the nucleus,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5752 T8234 T8258 locationOf the nucleus,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5753 T8238 T8257 themeOf Δ133p53β,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5754 T8240 T8255 locationOf "in the cytoplasm (Bourdon et al., 2005)","Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)"
R5755 T8245 T8256 causeOf p53-dependent,gene expression in p53-dependent
R5756 T8247 T8259 themeOf of p53,co-expression of p53 with Δ133p53
R5757 T8252 T8250 causeOf Co-expression of Δ133p53β or Δ133p53γ with p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5758 T8253 T8251 causeOf Co-expression of Δ133p53β or Δ133p53γ with p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5759 T8259 T8248 themeOf co-expression of p53 with Δ133p53,co-expression of p53 with Δ133p53 suppresses
R6228 T9124 T9175 themeOf of WWOX,downregulation of WWOX
R6229 T9126 T9178 themeOf Mutant p53 proteins,Mutant p53 proteins cannot bind ectopic WWOX in GBM cells
R6230 T9135 T9176 themeOf of this protein with WWOX,binding of this protein with WWOX
R6231 T9153 T9177 themeOf WWOX,Altered WWOX expression
R6232 T9166 T9179 themeOf Activated WWOX,Activated WWOX
R6233 T9167 T9178 themeOf ectopic WWOX,Mutant p53 proteins cannot bind ectopic WWOX in GBM cells
R6234 T9168 T9172 themeOf wild type p53,Activated WWOX binds wild type p53 with Ser46 phosphorylation
R6235 T9169 T9173 themeOf overexpressed WWOX,overexpressed WWOX
R6236 T9169 T9174 themeOf overexpressed WWOX,overexpressed WWOX
R6237 T9177 T9171 themeOf Altered WWOX expression,Altered WWOX expression
R7783 T11487 T11594 themeOf of ROS,generation of ROS to curb the cancer cell growth and invasion
R7784 T11510 T11598 themeOf with WWOX,"In most cases, we have shown that p53 functionally interacts with WWOX"
R7785 T11527 T11595 themeOf WWOX,"WWOX binds MEK,"
R7786 T11536 T11597 themeOf of ROS,generation of ROS
R7787 T11540 T11593 themeOf WWOX,low WWOX expression areas
R7788 T11550 T11595 themeOf "MEK,","WWOX binds MEK,"
R7789 T11553 T11598 themeOf p53,"In most cases, we have shown that p53 functionally interacts with WWOX"
R7790 T11559 T11592 themeOf WWOX,of WWOX expression
R7791 T11580 T11591 themeOf of TIAF1,Ectopic expression of TIAF1
R7792 T11581 T11596 themeOf ectopic WWOX,"In this event, ectopic WWOX is activated for inducing apoptosis"
R9475 T13699 T13773 themeOf WWOX,WWOX binds Tau via its SDR domain
R9476 T13700 T13769 themeOf the released WWOX,the released WWOX
R9477 T13703 T13772 themeOf Hyal-2,association with Hyal-2 and phospho-Ezrin
R9478 T13705 T13771 themeOf Dvl,binding Dvl
R9479 T13706 T13768 themeOf WWOX,WWOX is phosphorylated in Tyr33 and binds p53
R9480 T13706 T13770 themeOf WWOX,WWOX is phosphorylated in Tyr33
R9481 T13714 T13774 themeOf WWOX,WWOX binds Hyal-2
R9482 T13722 T13775 themeOf conserved tyrosine phosphorylation sites,conserved tyrosine phosphorylation sites
R9483 T13731 T13706 partOf Tyr33,WWOX
R9484 T13731 T13770 siteOf Tyr33,WWOX is phosphorylated in Tyr33
R9485 T13737 T13774 themeOf Hyal-2,WWOX binds Hyal-2
R9486 T13739 T13768 themeOf p53,WWOX is phosphorylated in Tyr33 and binds p53
R9487 T13747 T13749 partOf its SDR domain,Tau
R9488 T13747 T13773 siteOf its SDR domain,WWOX binds Tau via its SDR domain
R9489 T13749 T13773 themeOf Tau,WWOX binds Tau via its SDR domain
R9490 T13753 T13772 themeOf phospho-Ezrin,association with Hyal-2 and phospho-Ezrin
R9491 T13755 T13767 causeOf Phorbol ester,Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell