bionlp-st-ge-2016-test-ihmc  

PMC:3342329 / 7235-19092 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5332 44-56 Protein denotes CCR5−/− Mice
T5329 68-75 Protein denotes of CCR5
T5343 140-144 Protein denotes mice
T5344 146-167 Entity denotes B16-F0 melanoma cells
T5347 224-228 Protein denotes mice
T5348 230-234 Entity denotes n = 
T5330 295-311 Protein denotes the CCR5−/− mice
T5340 349-365 Protein denotes the CCR5+/+ mice
T5342 387-403 Protein denotes the CCR5−/− mice
T5327 454-462 Protein denotes the CCR5
T5326 466-470 Protein denotes mice
T5341 619-623 Protein denotes mice
T5349 709-736 Protein denotes mice (75% of starting time)
T5324 741-759 Protein denotes CCR5+/+ mice (15%)
T5339 863-875 Protein denotes CCR5−/− mice
T5325 880-892 Protein denotes CCR5+/+ mice
T5338 935-956 Protein denotes CCR5−/− mice survived
T5336 963-1000 Protein denotes only 15% of the CCR5+/+ mice survived
T5345 972-1000 Protein denotes of the CCR5+/+ mice survived
T5335 1042-1061 Protein denotes the sacrificed mice
T5333 1166-1193 Entity denotes proliferation antigen PCNA,
T5323 1166-1193 Protein denotes proliferation antigen PCNA,
T5331 1254-1258 Protein denotes mice
T5328 1336-1385 Protein denotes of the CCR5−/− mice, but not those of the CCR5+/+
T5350 1386-1391 Protein denotes mice,
T5337 1427-1431 Protein denotes PCNA
T5334 1427-1446 Entity denotes PCNA reactive cells
T5346 1489-1505 Protein denotes mice (Figure 1E)
T17675 1586-1598 Protein denotes CCR5−/− mice
T17677 1600-1603 Protein denotes A–C
T17672 1641-1679 Entity denotes B16 melanoma cells (5×105 cells/mouse)
T17683 1706-1735 Protein denotes CCR5+/+ mice and CCR5−/− mice
T17685 1714-1718 Protein denotes mice
T17676 1737-1741 Entity denotes n = 
T17684 1847-1863 Protein denotes The CCR5−/− mice
T17678 1931-1946 Protein denotes to CCR5+/+ mice
T17680 1977-1986 Protein denotes mean ± SD
T17679 2028-2049 Protein denotes CCR5+/+ mice (P<0.05)
T17686 2066-2070 Protein denotes mice
T17682 2129-2163 Protein denotes to CCR5+/+ mice (by Log-rank Test)
T17687 2214-2269 Gene_expression denotes expression of proliferating cell nuclear antigen (PCNA)
T17673 2225-2269 Protein denotes of proliferating cell nuclear antigen (PCNA)
T17681 2264-2268 Protein denotes PCNA
T17671 2312-2345 Entity denotes S.D. of four experimental animals
T17674 2387-2408 Protein denotes CCR5+/+ mice (P<0.05)
T18161 2437-2490 Negative_regulation denotes Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
T5902 2437-2490 Negative_regulation denotes Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
T18152 2449-2454 Protein denotes NF-κB
T5893 2449-2454 Protein denotes NF-κB
T18147 2491-2495 Protein denotes Mice
T5884 2491-2495 Protein denotes Mice
T5899 2496-2519 Positive_regulation denotes The activation of NF-κB
T5892 2511-2519 Protein denotes of NF-κB
T5896 2545-2566 Entity denotes cancer cell survival,
T5885 2578-2599 Entity denotes melanoma cancer cells
T5887 2607-2611 Protein denotes CCR5
T5900 2607-2622 Gene_expression denotes CCR5 expression
T5903 2682-2719 Negative_regulation denotes the inactivation of NF-κB in melanoma
T5897 2699-2707 Protein denotes of NF-κB
T5890 2746-2754 Protein denotes of NF-κB
T5886 2905-2909 Protein denotes mice
T5901 2946-3086 Negative_regulation denotes the translocation of p50 and p-p65 into the nucleus through the inhibition of phosphorylation of IκB was also prevented in the tumor tissues
T5898 2967-2970 Protein denotes p50
T5889 2975-2980 Protein denotes p-p65
T5891 2986-2997 Entity denotes the nucleus
T5894 3098-3114 Protein denotes mice (Figure 2B)
T5895 3202-3205 Protein denotes p50
T5888 3252-3268 Protein denotes mice (Figure 2C)
T18159 3441-3464 Entity denotes extracts of the CCR5−/−
T18151 3465-3469 Protein denotes mice
T18153 3474-3486 Protein denotes CCR5+/+ mice
T18162 3547-3564 Gene_expression denotes Expression of p50
T18158 3558-3564 Protein denotes of p50
T18149 3569-3572 Protein denotes p65
T18163 3569-3614 Phosphorylation denotes p65 phosphorylation in nuclear extracts (NE),
T18148 3592-3613 Entity denotes nuclear extracts (NE)
T18155 3650-3661 Entity denotes the cytosol
T18160 3731-3737 Protein denotes of p50
T18157 3793-3796 Protein denotes p50
T18156 3844-3848 Protein denotes mice
T18150 3867-3900 Entity denotes S.D. of four experimental animals
T18154 3942-3963 Protein denotes CCR5+/+ mice (p<0.05)
T6415 4031-4095 Negative_regulation denotes Inhibition of the Expression of Anti-apoptotic Proteins in CCR5−
T6408 4068-4095 Protein denotes apoptotic Proteins in CCR5−
T6399 4098-4102 Protein denotes Mice
T6413 4118-4146 Negative_regulation denotes inhibition of NF-κB activity
T6396 4132-4137 Protein denotes NF-κB
T6414 4307-4361 Gene_expression denotes expression of apoptotic cell death regulatory proteins
T6398 4318-4361 Protein denotes of apoptotic cell death regulatory proteins
T6404 4454-4466 Protein denotes CCR5−/− mice
T6403 4493-4507 Entity denotes melanoma cells
T6410 4579-4616 Protein denotes the tumor tissues of the CCR5−/− mice
T6412 4579-4617 Localization denotes the tumor tissues of the CCR5−/− mice
T6395 4630-4658 Protein denotes the CCR5+/+ mice (Figure 3A)
T6397 4738-4747 Protein denotes caspase-3
T6405 4752-4755 Protein denotes Bax
T6411 4798-4802 Protein denotes mice
T6401 4811-4846 Protein denotes the CCR5+/+ mice (Figure 3B and 3C)
T6406 4916-4933 Protein denotes of tumor proteins
T6394 4959-5006 Protein denotes levels of cleaved caspase-3, cleaved caspase-9,
T6400 4996-5005 Protein denotes caspase-9
T6409 5015-5019 Protein denotes PARP
T6407 5024-5027 Protein denotes Bax
T6392 5051-5056 Protein denotes Bcl-2
T6402 5061-5067 Protein denotes C-IAP1
T6393 5108-5112 Protein denotes mice
T18555 5215-5245 Localization denotes tumor tissues of CCR5 −/− mice
T18545 5215-5245 Protein denotes tumor tissues of CCR5 −/− mice
T18546 5229-5236 Protein denotes of CCR5
T18538 5260-5265 Entity denotes cells
T18527 5331-5335 Entity denotes DAPI
T18537 5442-5457 Entity denotes of DAPI-stained
T18544 5459-5489 Entity denotes TUNEL-positive cells that were
T18540 5521-5554 Protein denotes S.D. of four experimental animals
T18539 5611-5623 Protein denotes CCR5+/+ mice
T18535 5661-5706 Protein denotes Apoptotic protein (cleaved caspase-3 and Bax)
T18525 5688-5697 Protein denotes caspase-3
T18543 5702-5705 Protein denotes Bax
T18532 5822-5899 Entity denotes of DAPI-stained, Specific antibody (cleaved caspase-3 and Bax)-positive cells
T18536 5825-5837 Entity denotes DAPI-stained
T18553 5848-5884 Entity denotes antibody (cleaved caspase-3 and Bax)
T18552 5866-5875 Protein denotes caspase-3
T18533 5880-5883 Protein denotes Bax
T18547 5941-5974 Protein denotes S.D. of four experimental animals
T18551 6031-6043 Protein denotes CCR5+/+ mice
T18554 6075-6111 Gene_expression denotes The expression of apoptotic proteins
T18530 6090-6111 Protein denotes of apoptotic proteins
T18549 6151-6170 Entity denotes specific antibodies
T18534 6180-6209 Protein denotes caspase-3, cleaved caspase-9,
T18542 6199-6208 Protein denotes caspase-9
T18529 6218-6222 Protein denotes PARP
T18526 6224-6227 Protein denotes Bax
T18541 6229-6234 Protein denotes Bcl-2
T18548 6239-6245 Protein denotes c-IAP1
T18524 6268-6287 Protein denotes The β-actin protein
T18550 6268-6287 Protein denotes The β-actin protein
T18528 6409-6443 Entity denotes S.D. of three experimental animals
T18531 6485-6506 Protein denotes CCR5+/+ mice (p<0.05)
T19295 6509-6564 Positive_regulation denotes Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−
T7227 6509-6571 Positive_regulation denotes Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−/− Mice
T19293 6522-6531 Protein denotes of IL-1Ra
T7223 6522-6531 Protein denotes of IL-1Ra
T19286 6535-6564 Protein denotes the Tumor and Spleen of CCR5−
T7212 6559-6571 Protein denotes CCR5−/− Mice
T19288 6567-6571 Protein denotes Mice
T7219 6605-6617 Protein denotes the cytokine
T7214 6689-6693 Protein denotes mice
T7218 6708-6771 Protein denotes a cytokine array assay using a Mouse Proteome Array (Figure 4A)
T7208 6789-6821 Protein denotes cytokines, the levels of IL-1Ra,
T7217 6814-6820 Protein denotes IL-1Ra
T7220 6822-6826 Protein denotes MIG,
T7207 6822-6833 Protein denotes MIG, MIP-1α
T7224 6894-6898 Protein denotes mice
T7206 6919-6923 Protein denotes mice
T7211 6947-6965 Protein denotes no other cytokines
T7213 7001-7017 Protein denotes the CCR5−/− mice
T7210 7022-7050 Protein denotes the CCR5+/+ mice (Figure 4B)
T7221 7110-7137 Protein denotes of CCR5−/− mice (Figure 4C)
T7209 7149-7155 Protein denotes IL-1Ra
T7226 7199-7298 Gene_expression denotes the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western
T7216 7214-7223 Protein denotes of IL-1Ra
T7228 7309-7333 Gene_expression denotes The expression of IL-1Ra
T7225 7309-7392 Positive_regulation denotes The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/−
T7215 7324-7333 Protein denotes of IL-1Ra
T7222 7393-7397 Protein denotes mice
T19268 7544-7582 Protein denotes mouse cytokine array panel coordinates
T19292 7584-7598 Entity denotes Nitrocellulose
T19281 7584-7608 Entity denotes Nitrocellulose membranes
T19275 7620-7654 Entity denotes different anti-cytokine antibodies
T19278 7686-7706 Protein denotes cytokine array panel
T19297 7716-7795 Gene_expression denotes the cytokine expression difference in tumor tissues of CCR5+/+ mice and CCR5−/−
T19267 7720-7728 Protein denotes cytokine
T19283 7771-7783 Protein denotes CCR5+/+ mice
T19269 7796-7801 Protein denotes mice,
T19279 7796-7819 Entity denotes mice, especially IL-1Ra
T19271 7965-7977 Entity denotes the membrane
T19276 7979-8003 Protein denotes C, Protein immune-arrays
T19294 8025-8063 Protein denotes Mouse cytokine array in spleen tissues
T19291 8091-8100 Protein denotes cytokines
T19289 8109-8139 Protein denotes CCR5+/+ mice and CCR5−/− mice,
T19282 8117-8121 Protein denotes mice
T19270 8303-8315 Entity denotes the membrane
T19290 8402-8408 Protein denotes IL-1Ra
T19277 8492-8539 Protein denotes of DAPI-stained, IL-1Ra antibody-positive cells
T19274 8495-8507 Entity denotes DAPI-stained
T19280 8516-8524 Protein denotes antibody
T19273 8581-8614 Entity denotes S.D. of four experimental animals
T19287 8671-8683 Protein denotes CCR5+/+ mice
T19296 8721-8802 Gene_expression denotes Expression of IL-1Ra was analyzed by western blotting in tumor and spleen tissues
T19272 8732-8741 Protein denotes of IL-1Ra
T19284 8892-8926 Entity denotes S.D. of three experimental animals
T19285 8968-8989 Protein denotes CCR5+/+ mice (p<0.05)
T8653 9005-9008 Protein denotes CD8
T8612 9005-9016 Entity denotes CD8 T cells
T8633 9021-9028 Entity denotes NK Cell
T8636 9047-9079 Protein denotes Tumor and Spleen of CCR5−/− Mice
T8637 9137-9149 Protein denotes CCR5−/− mice
T8668 9238-9259 Entity denotes CD8+ cytotoxic T cell
T8634 9264-9318 Entity denotes CD57+ Natural Killer cells in tumor and spleen tissues
T8667 9356-9368 Protein denotes CCR5−/− mice
T8666 9418-9428 Entity denotes CD8+ cells
T8669 9445-9518 Binding denotes as well as an increase in the number of infiltrating NK cells (Figure 5A)
T8627 9498-9518 Entity denotes NK cells (Figure 5A)
T8635 9520-9532 Entity denotes CD8+ T cells
T8671 9520-9604 Binding denotes CD8+ T cells and CD57+ NK cells were spread diffusely throughout the entire sections
T8658 9537-9551 Entity denotes CD57+ NK cells
T8646 9660-9675 Entity denotes of CD8+ T cells
T8652 9680-9694 Entity denotes CD57+ NK cells
T8659 9703-9715 Protein denotes CCR5+/+ mice
T8643 9720-9725 Protein denotes CCR5−
T8670 9726-9759 Localization denotes − mice in immunity-related organ,
T8618 9726-9759 Protein denotes − mice in immunity-related organ,
T8611 9777-9784 Protein denotes the CD8
T8632 9789-9793 Protein denotes CD57
T8625 9845-9860 Entity denotes of CD8+ T cells
T8623 9865-9879 Entity denotes CD57+ NK cells
T8631 9921-9925 Protein denotes mice
T8638 9945-9964 Protein denotes of the CCR5+/+ mice
T8639 10035-10038 Protein denotes CD8
T8622 10035-10046 Entity denotes CD8 T cells
T8624 10051-10059 Entity denotes NK cells
T8641 10078-10087 Entity denotes cytotoxic
T8651 10155-10167 Protein denotes CCR5−/− mice
T19901 10246-10258 Entity denotes CD8+ T cells
T19905 10263-10271 Entity denotes NK cells
T19902 10318-10322 Protein denotes mice
T19903 10409-10451 Protein denotes CD8 (CD8+ cytotoxic T-cell surface marker)
T19897 10414-10450 Entity denotes CD8+ cytotoxic T-cell surface marker
T19896 10414-10450 Entity denotes CD8+ cytotoxic T-cell surface marker
T19894 10414-10450 Entity denotes CD8+ cytotoxic T-cell surface marker
T19900 10462-10469 Entity denotes NK cell
T19904 10663-10687 Entity denotes of lymphocyte phenotypes
T19895 10808-10832 Protein denotes FACSAria flow cytometry,
T19899 10812-10816 Protein denotes Aria
T19898 10881-10914 Entity denotes S.D. of four experimental animals
T8616 10927-10963 Entity denotes the cell phenotype change in CCR5−/−
T8649 10964-10968 Protein denotes mice
T8642 10973-11022 Protein denotes CCR5+/+ mice by inoculation of the melanoma cell,
T8629 11001-11021 Entity denotes of the melanoma cell
T8621 11023-11034 Entity denotes lymphocytes
T8644 11091-11094 Protein denotes CD3
T8610 11091-11096 Entity denotes CD3 T
T8606 11098-11101 Protein denotes CD4
T8626 11098-11103 Entity denotes CD4 T
T8608 11108-11111 Entity denotes 8 T
T8665 11116-11123 Entity denotes NK cell
T8647 11143-11147 Protein denotes mice
T8630 11256-11268 Protein denotes 3.1% of CCR5
T8640 11272-11288 Protein denotes mice (Figure 5C)
T8619 11290-11354 Entity denotes The lymphocytes that infiltrated the tumor tissue of the CCR5−/−
T8656 11355-11359 Protein denotes mice
T8655 11386-11401 Protein denotes CD19, CD3, CD4,
T8660 11386-11405 Protein denotes CD19, CD3, CD4, CD8
T8663 11392-11396 Protein denotes CD3,
T8620 11392-11400 Protein denotes CD3, CD4
T8654 11429-11448 Protein denotes to the CCR5+/+ mice
T8657 11457-11460 Protein denotes CD3
T8628 11457-11462 Entity denotes CD3 T
T8661 11464-11467 Protein denotes CD4
T8648 11464-11469 Entity denotes CD4 T
T8617 11476-11477 Entity denotes T
T8615 11482-11512 Entity denotes NK cell portion of the CCR5−/−
T8609 11513-11517 Protein denotes mice
T8664 11619-11655 Protein denotes 3.9% of the CCR5+/+ mice (Figure 5D)
T8607 11624-11655 Protein denotes of the CCR5+/+ mice (Figure 5D)
T8614 11714-11717 Protein denotes CD8
T8650 11714-11725 Entity denotes CD8 T cells
T8645 11730-11738 Entity denotes NK cells
T8613 11757-11766 Entity denotes cytotoxic
T8662 11844-11856 Protein denotes CCR5−/− mice
R12778 T17673 T17687 themeOf of proliferating cell nuclear antigen (PCNA),expression of proliferating cell nuclear antigen (PCNA)
R13081 T18149 T18163 themeOf p65,"p65 phosphorylation in nuclear extracts (NE),"
R13082 T18152 T18161 themeOf NF-κB,Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
R13083 T18158 T18162 themeOf of p50,Expression of p50
R13302 T18530 T18554 themeOf of apoptotic proteins,The expression of apoptotic proteins
R13303 T18545 T18555 themeOf tumor tissues of CCR5 −/− mice,tumor tissues of CCR5 −/− mice
R13800 T19267 T19297 themeOf cytokine,the cytokine expression difference in tumor tissues of CCR5+/+ mice and CCR5−/−
R13801 T19272 T19296 themeOf of IL-1Ra,Expression of IL-1Ra was analyzed by western blotting in tumor and spleen tissues
R13802 T19293 T19295 themeOf of IL-1Ra,Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−
R4050 T5887 T5900 themeOf CCR5,CCR5 expression
R4051 T5892 T5899 themeOf of NF-κB,The activation of NF-κB
R4052 T5893 T5902 themeOf NF-κB,Decrease of NF-κB Activity in Tumor Tissue of CCR5−/−
R4053 T5897 T5903 themeOf of NF-κB,the inactivation of NF-κB in melanoma
R4353 T6398 T6414 themeOf of apoptotic cell death regulatory proteins,expression of apoptotic cell death regulatory proteins
R4354 T6410 T6412 themeOf the tumor tissues of the CCR5−/− mice,the tumor tissues of the CCR5−/− mice
R4909 T7215 T7228 themeOf of IL-1Ra,The expression of IL-1Ra
R4910 T7216 T7226 themeOf of IL-1Ra,the expression of IL-1Ra in tumor and spleen tissues was analyzed by immunofluorescence and western
R4911 T7223 T7227 themeOf of IL-1Ra,Upregulation of IL-1Ra in the Tumor and Spleen of CCR5−/− Mice
R4912 T7228 T7225 themeOf The expression of IL-1Ra,The expression of IL-1Ra was upregulated in tumor and spleen tissues of the CCR5−/−
R5871 T8618 T8670 themeOf "− mice in immunity-related organ,","− mice in immunity-related organ,"