bionlp-st-ge-2016-test-ihmc

PMC:3320587 JSON TXT 30 Projects

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Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T805	94-99	Protein	denotes	NFAT5
T798	103-125	Protein	denotes	the Toll-Like Receptor
T813	421-578	Negative_regulation	denotes	we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T812	451-578	Gene_expression	denotes	of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T821	469-578	Negative_regulation	denotes	of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T795	469-578	Protein	denotes	of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T797	497-542	Protein	denotes	nuclear factor of activated T cells 5 (NFAT5)
T803	536-541	Protein	denotes	NFAT5
T804	607-610	Protein	denotes	MTb
T786	644-667	Entity	denotes	co-infected macrophages
T800	682-687	Protein	denotes	NFAT5
T809	682-692	Protein	denotes	NFAT5 gene
T806	697-704	Protein	denotes	protein
T816	697-715	Gene_expression	denotes	protein expression
T810	737-743	Protein	denotes	by MTb
T796	756-780	Protein	denotes	Toll-like receptor (TLR)
T780	756-788	Entity	denotes	Toll-like receptor (TLR) ligand,
T823	798-826	Binding	denotes	an intact NFAT5 binding site
T790	798-826	Entity	denotes	an intact NFAT5 binding site
T788	808-813	Protein	denotes	NFAT5
T782	830-875	Entity	denotes	the viral promoter of R5-tropic HIV-1 subtype
T787	965-971	Protein	denotes	by MTb
T791	1044-1060	Entity	denotes	human monocytes,
T808	1096-1105	Entity	denotes	molecules
T781	1106-1130	Protein	denotes	MyD88, IRAK1, and TRAF6,
T820	1106-1187	Negative_regulation	denotes	MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression
T792	1113-1119	Protein	denotes	IRAK1,
T802	1124-1129	Protein	denotes	TRAF6
T801	1154-1165	Protein	denotes	MTb-induced
T817	1154-1187	Gene_expression	denotes	MTb-induced NFAT5 gene expression
T794	1166-1171	Protein	denotes	NFAT5
T779	1225-1228	Protein	denotes	MTb
T822	1225-1238	Regulation	denotes	MTb infection
T778	1247-1252	Protein	denotes	NFAT5
T784	1247-1257	Protein	denotes	NFAT5 gene
T793	1262-1269	Protein	denotes	protein
T818	1262-1280	Gene_expression	denotes	protein expression
T799	1286-1291	Protein	denotes	NFAT5
T814	1313-1400	Regulation	denotes	in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
T783	1316-1319	Protein	denotes	MTb
T815	1365-1400	Binding	denotes	interaction with the viral promoter
T785	1377-1400	Entity	denotes	with the viral promoter
T807	1453-1458	Protein	denotes	NFAT5
T789	1471-1483	Protein	denotes	MTb-mediated
T819	1471-1510	Regulation	denotes	MTb-mediated control of gene expression
T811	1471-1510	Regulation	denotes	MTb-mediated control of gene expression
T2713	2529-2532	Protein	denotes	MTb
T2709	2654-2697	Protein	denotes	human immunodeficiency virus type 1 (HIV-1)
T2762	2738-2766	Protein	denotes	recognition receptors (PRRs)
T2768	2761-2765	Protein	denotes	PRRs
T2727	2770-2773	Protein	denotes	MTb
T2746	2777-2799	Entity	denotes	mononuclear phagocytes
T2765	2931-2940	Protein	denotes	cytokines
T2705	2945-2964	Protein	denotes	chemokines produced
T2759	2998-3001	Protein	denotes	MTb
T2786	2998-3011	Regulation	denotes	MTb infection
T2754	3053-3056	Protein	denotes	CD4
T2748	3053-3064	Entity	denotes	CD4 T cells
T2716	3079-3084	Entity	denotes	cells
T2698	3200-3211	Protein	denotes	MTb-induced
T2758	3284-3287	Protein	denotes	CD4
T2718	3284-3294	Entity	denotes	CD4 T cell
T2781	3456-3483	Positive_regulation	denotes	of latent MTb reactivation,
T2761	3466-3469	Protein	denotes	MTb
T2777	3574-3635	Positive_regulation	denotes	The primary PRR on monocytic cells triggered by MTb infection
T2769	3574-3635	Protein	denotes	The primary PRR on monocytic cells triggered by MTb infection
T2785	3574-3636	Localization	denotes	The primary PRR on monocytic cells triggered by MTb infection
T2697	3593-3608	Entity	denotes	monocytic cells
T2778	3619-3635	Regulation	denotes	by MTb infection
T2714	3622-3625	Protein	denotes	MTb
T2719	3639-3670	Protein	denotes	toll-like receptor (TLR) 2 [16]
T2737	3691-3695	Protein	denotes	TLR2
T2751	3733-3855	Protein	denotes	protein MyD88 and the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6
T2699	3741-3746	Protein	denotes	MyD88
T2784	3751-3855	Binding	denotes	the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6
T2730	3781-3824	Protein	denotes	several kinases, including IRAK1 and IRAK4,
T2710	3808-3813	Protein	denotes	IRAK1
T2728	3818-3823	Protein	denotes	IRAK4
T2764	3829-3855	Protein	denotes	the ubiquitin ligase TRAF6
T2708	3829-3855	Protein	denotes	the ubiquitin ligase TRAF6
T2738	3833-3842	Protein	denotes	ubiquitin
T2739	3893-3898	Protein	denotes	TRAF6
T2782	3893-3969	Positive_regulation	denotes	TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
T2715	3909-3925	Protein	denotes	IκB kinase (IKK)
T2703	3909-3969	Protein	denotes	IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
T2707	3930-3947	Entity	denotes	mitogen-activated
T2787	3930-3961	Positive_regulation	denotes	mitogen-activated protein (MAP)
T2753	3930-3961	Protein	denotes	mitogen-activated protein (MAP)
T2702	3957-3960	Protein	denotes	MAP
T2776	4003-4046	Positive_regulation	denotes	activation of specific transcription factor
T2729	4014-4046	Protein	denotes	of specific transcription factor
T2747	4071-4076	Protein	denotes	NF-κB
T2749	4081-4085	Protein	denotes	AP-1
T2771	4343-4369	Entity	denotes	of activator binding sites
T2734	4364-4369	Entity	denotes	sites
T2696	4542-4547	Protein	denotes	NF-κB
T2750	4679-4693	Entity	denotes	southeast Asia
T2783	4714-4757	Binding	denotes	NF-κB binding sites, respectively [1], [28]
T2742	4714-4757	Protein	denotes	NF-κB binding sites, respectively [1], [28]
T2770	4728-4733	Entity	denotes	sites
T2704	4852-4866	Entity	denotes	T cells (NFAT)
T2701	4875-4880	Protein	denotes	NFAT5
T2736	4896-4902	Protein	denotes	TonEBP
T2745	4911-4920	Entity	denotes	to a site
T2722	5039-5054	Entity	denotes	This NFAT5 site
T2757	5044-5049	Protein	denotes	NFAT5
T2760	5064-5104	Protein	denotes	the core NF-κB binding motifs in the LTR
T2779	5064-5105	Localization	denotes	the core NF-κB binding motifs in the LTR
T2725	5068-5072	Entity	denotes	core
T2735	5212-5228	Entity	denotes	primary monocyte
T2711	5237-5254	Entity	denotes	macrophages (MDM)
T2744	5250-5253	Protein	denotes	MDM
T2731	5272-5277	Protein	denotes	NFAT5
T2724	5338-5360	Protein	denotes	by the MAP kinase p38,
T2700	5338-5360	Protein	denotes	by the MAP kinase p38,
T2694	5338-5360	Protein	denotes	by the MAP kinase p38,
T2706	5345-5348	Protein	denotes	MAP
T2726	5384-5389	Protein	denotes	MyD88
T2775	5384-5406	Positive_regulation	denotes	MyD88 signaling, [32],
T2755	5426-5431	Protein	denotes	NFAT5
T2766	5456-5467	Protein	denotes	MTb-induced
T2732	5530-5539	Entity	denotes	monocytes
T2743	5544-5578	Entity	denotes	peripheral blood mononuclear cells
T2752	5601-5611	Protein	denotes	that NFAT5
T2717	5636-5640	Entity	denotes	site
T2740	5671-5692	Protein	denotes	efficient MTb-induced
T2733	5735-5738	Protein	denotes	MDM
T2763	5743-5747	Entity	denotes	PBMC
T2772	5759-5871	Positive_regulation	denotes	we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
T2721	5779-5782	Protein	denotes	MTb
T2780	5779-5792	Regulation	denotes	MTb infection
T2767	5803-5808	Protein	denotes	NFAT5
T2774	5803-5843	Gene_expression	denotes	NFAT5 gene expression in human monocytes
T2712	5828-5843	Entity	denotes	human monocytes
T2741	5849-5864	Protein	denotes	MyD88-dependent
T2773	5918-5937	Gene_expression	denotes	of NFAT5 expression
T2723	5921-5926	Protein	denotes	NFAT5
T2695	5945-5957	Protein	denotes	PRR-mediated
T2720	6003-6008	Protein	denotes	NFAT5
T2756	6036-6047	Protein	denotes	MTb-induced
T2885	6188-6229	Entity	denotes	peripheral blood mononuclear cells, PBMC)
T2884	6224-6228	Entity	denotes	PBMC
T2883	6264-6268	Protein	denotes	Bank
T3452	6317-6353	Entity	denotes	PBMC from normal unidentified donors
T3455	6498-6529	Entity	denotes	2 mM L-glutamine (BioWhittaker,
T3442	6617-6653	Entity	denotes	Gemini Bio-Products, www.gembio.com)
T3456	6655-6670	Entity	denotes	Human monocytes
T3453	6685-6707	Entity	denotes	from PBMC preparations
T3441	6690-6694	Entity	denotes	PBMC
T3449	6735-6739	Protein	denotes	CD14
T3443	6756-6796	Protein	denotes	Miltenyi Biotec (www.miltenyibiotec.com)
T3450	6852-6863	Entity	denotes	1×106 cells
T3447	6964-6992	Protein	denotes	ng/ml recombinant human MCSF
T3448	7059-7079	Entity	denotes	Nabi, Boca Raton, FL
T3446	7082-7099	Entity	denotes	The cell cultures
T3457	7158-7169	Entity	denotes	supernatant
T3445	7209-7213	Protein	denotes	MCSF
T3458	7247-7299	Entity	denotes	% of the adherent cells obtained with this technique
T3460	7249-7299	Binding	denotes	of the adherent cells obtained with this technique
T3451	7249-7299	Entity	denotes	of the adherent cells obtained with this technique
T3454	7305-7322	Entity	denotes	CD14+ macrophages
T3444	7498-7508	Entity	denotes	293T cells
T3459	7498-7547	Binding	denotes	293T cells were obtained from ATCC (www.atcc.org)
T3570	7677-7685	Protein	denotes	HIV-1Bal
T3571	7813-7826	Entity	denotes	AIDS Reagents
T3572	7915-7917	Entity	denotes	25
T4046	8072-8083	Entity	denotes	nucleotides
T4047	8390-8423	Entity	denotes	Hind III restriction enzyme sites
T4050	8399-8417	Protein	denotes	restriction enzyme
T4051	8516-8550	Entity	denotes	NFAT5 binding site-mutant (N5-Mut)
T4052	8543-8549	Entity	denotes	N5-Mut
T4048	8543-8549	Protein	denotes	N5-Mut
T4049	8764-8791	Protein	denotes	Renilla luciferase (pRL-TK)
T4054	8784-8790	Protein	denotes	pRL-TK
T4053	8813-8843	Entity	denotes	Effectene transfection reagent
T4045	8870-8875	Entity	denotes	Cells
T4055	8950-8962	Protein	denotes	10 µg/ml MTb
T4299	9170-9177	Protein	denotes	DNase I
T4298	9191-9208	Protein	denotes	Recombinant NFAT5
T4292	9210-9221	Entity	denotes	amino acids
T4293	9236-9249	Entity	denotes	an N-terminal
T4291	9278-9301	Entity	denotes	E. coli BL21(DE3) cells
T4300	9378-9401	Entity	denotes	Ni-NTA agarose (Qiagen)
T4297	9381-9384	Entity	denotes	NTA
T4295	9403-9418	Protein	denotes	Recombinant p50
T4301	9403-9441	Binding	denotes	Recombinant p50 and p65 were purchased
T4296	9423-9426	Protein	denotes	p65
T4294	9479-9555	Protein	denotes	Quantitative DNase I footprinting was performed as previously described [31]
T4619	9686-9706	Entity	denotes	the NIH AIDS Reagent
T4616	9821-9824	Protein	denotes	env
T4618	9826-9831	Protein	denotes	gp160
T4620	9826-9843	Entity	denotes	gp160 amino acids
T4621	9893-9898	Protein	denotes	CXCR4
T4624	9983-9987	Protein	denotes	CCR5
T4623	10031-10035	Protein	denotes	CCR5
T4617	10039-10059	Protein	denotes	a secondary receptor
T4615	10129-10142	Entity	denotes	DNA extracted
T4622	10148-10152	Entity	denotes	PBMC
T5025	10373-10379	Protein	denotes	of MDM
T5028	10385-10388	Protein	denotes	RNA
T5023	10466-10486	Protein	denotes	the NFAT5 transcript
T5022	10470-10475	Protein	denotes	NFAT5
T5030	10564-10590	Protein	denotes	non-specific siRNA effects
T5024	10623-10655	Protein	denotes	green fluorescent protein (GFP),
T5027	10650-10653	Protein	denotes	GFP
T5026	10686-10689	Protein	denotes	MDM
T5031	10761-10794	Entity	denotes	siPORT NeoFX transfection reagent
T5033	11018-11023	Entity	denotes	cells
T5032	11067-11070	Protein	denotes	MDM
T5029	11126-11131	Protein	denotes	NFAT5
T5034	11126-11142	Gene_expression	denotes	NFAT5 expression
T5592	11194-11229	Gene_expression	denotes	Stable THP-1 cells expressing shRNA
T5591	11194-11229	Transcription	denotes	Stable THP-1 cells expressing shRNA
T5581	11194-11229	Entity	denotes	Stable THP-1 cells expressing shRNA
T5569	11224-11229	Protein	denotes	shRNA
T5575	11271-11298	Protein	denotes	shRNA targeting human MyD88
T5573	11287-11298	Protein	denotes	human MyD88
T5585	11396-11401	Protein	denotes	shRNA
T5582	11396-11502	Protein	denotes	shRNA targeting human IRAK1 (forward primer 5′-CCGGAGCAGCTGTCCAGGTTTCGTCTCATAAAACCTGGACAGCTGCTCCTTTTTG-3′,
T5571	11511-11584	Protein	denotes	primer 5′-AATTCAAAAAGGAGCAGCTGTCCAGGTTTTATGAGACGAAACCTGGACAGCTGCT-3′ mRNA
T5568	11586-11591	Protein	denotes	IRAK1
T5590	11592-11596	Protein	denotes	mRNA
T5576	11632-11722	Protein	denotes	human TRAF6 (forward primer 5′-CCGGAGAAACCTGTTGTGATTCGTCTCATAAATCACAACAGGTTTCTCCTTTTTG-3′,
T5572	11801-11806	Protein	denotes	TRAF6
T5577	11807-11811	Protein	denotes	mRNA
T5589	11938-11943	Protein	denotes	shRNA
T5578	12023-12041	Protein	denotes	the shRNA-encoding
T5586	12102-12106	Protein	denotes	PAX2
T5570	12155-12175	Entity	denotes	transfection reagent
T5580	12202-12214	Entity	denotes	Supernatants
T5587	12341-12365	Entity	denotes	the lentiviral particles
T5583	12379-12388	Entity	denotes	the cells
T5588	12394-12421	Entity	denotes	supernatants from the virus
T5579	12432-12437	Entity	denotes	cells
T5584	12465-12474	Entity	denotes	polybrene
T5567	12575-12580	Entity	denotes	cells
T5574	12626-12645	Entity	denotes	0.8 µg/ml puromycin
T5971	12648-12651	Protein	denotes	MTb
T5975	12664-12667	Protein	denotes	MTb
T5974	12785-12788	Protein	denotes	Dif
T5972	12785-12790	Entity	denotes	Difco
T5983	12825-12855	Entity	denotes	albumin dextrose complex (ADC)
T5982	12825-12855	Protein	denotes	albumin dextrose complex (ADC)
T5979	12825-12855	Entity	denotes	albumin dextrose complex (ADC)
T5978	12851-12854	Entity	denotes	ADC
T5980	12876-12881	Protein	denotes	Sigma
T5977	13156-13180	Entity	denotes	a single cell suspension
T5973	13252-13299	Entity	denotes	further dilution with RPMI 1640 medium for cell
T5976	13295-13299	Entity	denotes	cell
T5984	13572-13596	Regulation	denotes	infection of primary MDM
T5981	13582-13596	Protein	denotes	of primary MDM
T6494	13623-13631	Entity	denotes	extracts
T6512	13676-13704	Entity	denotes	150 mM NaCl, 50 mM Tris–HCl,
T6513	13695-13703	Entity	denotes	Tris–HCl
T6506	13695-13703	Entity	denotes	Tris–HCl
T6497	13700-13703	Entity	denotes	HCl
T6504	13713-13722	Entity	denotes	1% Triton
T6495	13724-13736	Entity	denotes	10% glycerol
T6500	13754-13781	Protein	denotes	Complete EDTA-free Protease
T6509	13763-13772	Entity	denotes	EDTA-free
T6493	13782-13791	Entity	denotes	Inhibitor
T6516	13830-13838	Entity	denotes	Extracts
T6502	13897-13918	Entity	denotes	v/v 2-mercaptoethanol
T6505	13923-13931	Protein	denotes	proteins
T6510	13960-13967	Entity	denotes	The gel
T6511	13987-14041	Entity	denotes	a nitrocellulose Trans-Blot Transfer Membrane (BioRad)
T6492	13987-14041	Entity	denotes	a nitrocellulose Trans-Blot Transfer Membrane (BioRad)
T6490	14004-14009	Protein	denotes	Trans
T6501	14073-14076	Entity	denotes	1 h
T6519	14088-14098	Entity	denotes	a solution
T6499	14102-14116	Protein	denotes	4% BSA (Sigma)
T6496	14110-14115	Protein	denotes	Sigma
T6507	14167-14177	Entity	denotes	50 mM Tris
T6503	14182-14193	Entity	denotes	150 mM NaCl
T6491	14205-14208	Protein	denotes	BSA
T6515	14272-14309	Entity	denotes	of rabbit anti-NFAT5 antibody (H-300)
T6508	14311-14316	Protein	denotes	Santa
T6518	14358-14388	Protein	denotes	of goat anti-Lamin-B1 antibody
T6498	14399-14404	Protein	denotes	Santa
T6517	14441-14464	Entity	denotes	2 h at room temperature
T6514	14533-14573	Protein	denotes	anti-goat-HRP (Santa Cruz Biotechnology)
T6520	14692-14747	Entity	denotes	SuperSignal West Pico Chemiluminescent Reagent (Pierce)
T6671	14750-14766	Protein	denotes	Quantitative PCR
T6674	14767-14793	Transcription	denotes	The mRNA expression levels
T6673	14767-14793	Gene_expression	denotes	The mRNA expression levels
T6672	14771-14775	Protein	denotes	mRNA
T6670	14810-14891	Protein	denotes	by SYBR Green-based real-time PCR (Applied Biosystems, www.appliedbiosystems.com)
T6669	15033-15045	Protein	denotes	β-actin mRNA
T6668	15033-15045	Protein	denotes	β-actin mRNA
T6753	15230-15296	Entity	denotes	the paired Student t-Test with the aid of Microsoft Excel software
T7248	15343-15346	Protein	denotes	MTb
T7251	15439-15457	Positive_regulation	denotes	of MTb stimulation
T7249	15442-15445	Protein	denotes	MTb
T7250	15638-15684	Binding	denotes	linked to the firefly luciferase reporter gene
T7242	15645-15684	Protein	denotes	to the firefly luciferase reporter gene
T7239	15652-15670	Protein	denotes	firefly luciferase
T7243	15821-15832	Protein	denotes	MTb (H37Rv)
T7240	15826-15829	Entity	denotes	H37
T7245	15847-15850	Protein	denotes	MTb
T7244	15892-15901	Entity	denotes	monocytes
T7247	15950-15953	Protein	denotes	MTb
T7246	16081-16091	Protein	denotes	luciferase
T7241	16397-16400	Protein	denotes	TNF
T22261	16471-16476	Protein	denotes	NFAT5
T22303	16471-16501	Binding	denotes	NFAT5 interaction with the LTR
T22302	16519-16530	Protein	denotes	MTb-induced
T22284	16556-16559	Protein	denotes	MTb
T22306	16556-16571	Positive_regulation	denotes	MTb stimulation
T22263	16703-16707	Entity	denotes	site
T22289	16781-16793	Protein	denotes	plasmid pGL3
T22286	16881-16903	Protein	denotes	the Renilla luciferase
T22256	16912-16939	Protein	denotes	plasmid pRL-TK (0.03 µg/ml)
T22254	16976-16981	Entity	denotes	Cells
T22293	17039-17042	Protein	denotes	MTb
T22270	17165-17180	Entity	denotes	untreated cells
T22280	17259-17274	Entity	denotes	untreated cells
T22255	17326-17329	Protein	denotes	MTb
T22298	17326-17351	Entity	denotes	MTb lysate-treated cells,
T22290	17432-17461	Entity	denotes	cells treated with MTb lysate
T22283	17451-17454	Protein	denotes	MTb
T22262	17587-17590	Protein	denotes	MTb
T22257	17709-17727	Entity	denotes	p<0.05; **, p<0.01
T22305	17771-17920	Negative_regulation	denotes	Specific disruption of the NFAT5 binding site significantly reduces LTR-reporter gene activity in monocytic cells in response to MTb lysate treatment
T22307	17791-17816	Binding	denotes	of the NFAT5 binding site
T22260	17791-17816	Entity	denotes	of the NFAT5 binding site
T22275	17798-17803	Protein	denotes	NFAT5
T22265	17852-17856	Protein	denotes	gene
T22281	17869-17884	Entity	denotes	monocytic cells
T22272	17900-17903	Protein	denotes	MTb
T22300	17956-17966	Protein	denotes	luciferase
T22296	17995-18006	Entity	denotes	nucleotides
T22309	18079-18120	Binding	denotes	the NFAT5 binding site mutations (N5-Mut)
T22279	18079-18120	Entity	denotes	the NFAT5 binding site mutations (N5-Mut)
T22276	18083-18088	Protein	denotes	NFAT5
T22292	18113-18119	Entity	denotes	N5-Mut
T22266	18113-18119	Protein	denotes	N5-Mut
T22291	18138-18147	Entity	denotes	the cells
T22285	18182-18194	Protein	denotes	10 µg/ml MTb
T22308	18223-18250	Negative_regulation	denotes	Disruption of NFAT5 binding
T22273	18234-18242	Protein	denotes	of NFAT5
T22282	18375-18380	Entity	denotes	cells
T22259	18399-18402	Protein	denotes	MTb
T22301	18411-18413	Entity	denotes	p<
T22297	18456-18475	Entity	denotes	the untreated cells
T22304	18595-18632	Regulation	denotes	Renilla luciferase control expression
T22278	18603-18613	Protein	denotes	luciferase
T22288	18658-18668	Entity	denotes	Nucleotide
T22267	18710-18715	Protein	denotes	NFAT5
T22258	18794-18797	Protein	denotes	MTb
T22295	18815-18820	Protein	denotes	NFAT5
T22268	18815-18854	Protein	denotes	NFAT5 protein levels in monocytic cells
T22277	18839-18854	Entity	denotes	monocytic cells
T22294	18921-18924	Protein	denotes	MTb
T22264	18959-18978	Entity	denotes	Whole cell extracts
T22299	19028-19047	Entity	denotes	anti-NFAT5 antibody
T22271	19052-19086	Protein	denotes	antibody directed against Lamin-B1
T22274	19078-19086	Protein	denotes	Lamin-B1
T22287	19168-19173	Protein	denotes	NFAT5
T22269	19314-19317	Protein	denotes	MTb
T8074	19327-19442	Negative_regulation	denotes	Specific disruption of NFAT5 binding impairs LTR-driven transcription in THP-1 cells in response to MTb stimulation
T8049	19350-19355	Protein	denotes	NFAT5
T8070	19427-19430	Protein	denotes	MTb
T8077	19427-19442	Positive_regulation	denotes	MTb stimulation
T8066	19452-19482	Protein	denotes	the transcription factor NFAT5
T8057	19456-19476	Protein	denotes	transcription factor
T8041	19494-19498	Entity	denotes	core
T8067	19571-19588	Entity	denotes	two thymines (TT)
T8054	19604-19618	Entity	denotes	cytosines (CC)
T8061	19615-19617	Entity	denotes	CC
T8060	19622-19640	Protein	denotes	the proximal NF-κB
T8068	19662-19668	Protein	denotes	N5-Mut
T8047	19662-19668	Entity	denotes	N5-Mut
T8076	19693-19713	Binding	denotes	the binding of NFAT5
T8065	19705-19713	Protein	denotes	of NFAT5
T8075	19745-19778	Binding	denotes	binding of NF-κB unperturbed [31]
T8050	19753-19773	Protein	denotes	of NF-κB unperturbed
T8046	19811-19824	Protein	denotes	NFAT5 for MTb
T8062	19821-19824	Protein	denotes	MTb
T8042	19878-19883	Protein	denotes	NFAT5
T8052	19964-19967	Protein	denotes	MTb
T8048	20017-20020	Protein	denotes	MTb
T8080	20053-20085	Binding	denotes	of the NFAT5 binding site-mutant
T8064	20053-20085	Entity	denotes	of the NFAT5 binding site-mutant
T8072	20117-20119	Entity	denotes	p<
T8078	20166-20188	Binding	denotes	the NFAT5 binding site
T8051	20166-20188	Entity	denotes	the NFAT5 binding site
T8058	20170-20175	Protein	denotes	NFAT5
T8043	20216-20258	Entity	denotes	THP-1 cells stimulated with the MTb lysate
T8040	20248-20251	Protein	denotes	MTb
T8056	20351-20354	Protein	denotes	MTb
T8081	20351-20408	Positive_regulation	denotes	MTb lysate stimulation directly enhances NFAT5 expression
T8069	20392-20397	Protein	denotes	NFAT5
T8079	20392-20408	Gene_expression	denotes	NFAT5 expression
T8053	20439-20444	Entity	denotes	cells
T8045	20502-20507	Protein	denotes	NFAT5
T8063	20502-20522	Protein	denotes	NFAT5 protein levels
T8059	20577-20582	Protein	denotes	NFAT5
T8073	20577-20597	Protein	denotes	NFAT5 protein levels
T8039	20632-20635	Protein	denotes	MTb
T8044	20689-20692	Protein	denotes	MTb
T8071	20723-20728	Protein	denotes	NFAT5
T8055	20768-20770	Entity	denotes	MT
T8725	20810-20813	Protein	denotes	MTb
T8726	20824-20841	Protein	denotes	NFAT5 mRNA levels
T8737	20830-20834	Protein	denotes	mRNA
T8724	20845-20854	Protein	denotes	human MDM
T8722	20866-20925	Entity	denotes	macrophages, which are the primary target of MTb infection,
T8713	20911-20914	Entity	denotes	MTb
T8734	21021-21024	Protein	denotes	MTb
T8739	21033-21095	Positive_regulation	denotes	to directly enhance NFAT5 mRNA expression in primary human MDM
T8733	21053-21058	Protein	denotes	NFAT5
T8714	21053-21063	Protein	denotes	NFAT5 mRNA
T8743	21053-21074	Gene_expression	denotes	NFAT5 mRNA expression
T8729	21078-21095	Protein	denotes	primary human MDM
T8735	21109-21112	Protein	denotes	MDM
T8711	21149-21158	Entity	denotes	the cells
T8720	21168-21171	Protein	denotes	MTb
T8717	21219-21224	Protein	denotes	NFAT5
T8738	21219-21296	Gene_expression	denotes	NFAT5 gene expression levels by quantitative real-time PCR at 24 and 48 hours
T8730	21366-21386	Protein	denotes	NFAT5 mRNA synthesis
T8740	21390-21443	Regulation	denotes	infecting MDM with live or heat-inactivated R5-tropic
T8715	21400-21403	Protein	denotes	MDM
T8732	21409-21443	Entity	denotes	live or heat-inactivated R5-tropic
T8736	21562-21565	Protein	denotes	MTb
T8718	21597-21614	Protein	denotes	NFAT5 mRNA levels
T8727	21603-21607	Protein	denotes	mRNA
T8719	21622-21623	Entity	denotes	p
T8731	21638-21639	Entity	denotes	p
T8721	21735-21740	Protein	denotes	NFAT5
T8728	21735-21764	Protein	denotes	NFAT5 mRNA levels (Figure 2A)
T8742	21766-21832	Positive_regulation	denotes	Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM
T8712	21772-21775	Protein	denotes	MTb
T8716	21798-21803	Protein	denotes	NFAT5
T8723	21798-21808	Protein	denotes	NFAT5 mRNA
T8741	21798-21819	Gene_expression	denotes	NFAT5 mRNA expression
T8710	21823-21832	Protein	denotes	human MDM
T23562	21970-21973	Protein	denotes	MTb
T16832	21970-21973	Protein	denotes	MTb
T23548	21982-21987	Protein	denotes	NFAT5
T16848	21982-21987	Protein	denotes	NFAT5
T23572	21982-22003	Gene_expression	denotes	NFAT5 gene expression
T16896	21982-22003	Gene_expression	denotes	NFAT5 gene expression
T23544	22018-22026	Protein	denotes	of NFAT5
T23552	22060-22063	Protein	denotes	MTb
T23575	22060-22076	Regulation	denotes	MTb co-infection
T23545	22082-22099	Protein	denotes	MTb but not HIV-1
T23540	22110-22130	Protein	denotes	NFAT5 mRNA synthesis
T23533	22134-22151	Entity	denotes	human macrophages
T23527	22153-22156	Protein	denotes	MDM
T23571	22171-22213	Binding	denotes	from PBMC obtained from four normal donors
T23529	22171-22213	Entity	denotes	from PBMC obtained from four normal donors
T23555	22215-22224	Entity	denotes	The cells
T23532	22264-22298	Entity	denotes	heat-inactivated or live R5-tropic
T23514	22339-22342	Protein	denotes	MTb
T23556	22419-22422	Protein	denotes	PCR
T23531	22432-22440	Protein	denotes	of NFAT5
T23522	22441-22445	Protein	denotes	mRNA
T23524	22519-22524	Protein	denotes	NFAT5
T23538	22519-22529	Protein	denotes	NFAT5 mRNA
T23516	22553-22558	Entity	denotes	cells
T23560	22724-22727	Protein	denotes	MTb
T23539	22733-22747	Protein	denotes	NFAT5-specific
T23573	22754-22853	Negative_regulation	denotes	effectively suppresses NFAT5 expression in MDM in both the absence and presence of MTb co-infection
T23546	22777-22782	Protein	denotes	NFAT5
T23569	22777-22800	Gene_expression	denotes	NFAT5 expression in MDM
T23564	22797-22800	Protein	denotes	MDM
T23574	22834-22853	Regulation	denotes	of MTb co-infection
T23554	22837-22840	Protein	denotes	MTb
T23563	22855-22858	Protein	denotes	MDM
T23547	22944-22956	Protein	denotes	RNA specific
T23549	22961-22966	Protein	denotes	NFAT5
T23551	22985-22988	Protein	denotes	GFP
T23550	23018-23021	Protein	denotes	MTb
T23541	23063-23072	Entity	denotes	the cells
T23515	23105-23108	Protein	denotes	MTb
T23570	23105-23118	Regulation	denotes	MTb infection
T23568	23105-23187	Positive_regulation	denotes	MTb infection significantly increased NFAT5 expression in comparison to uninfected
T23557	23143-23148	Protein	denotes	NFAT5
T23565	23143-23159	Gene_expression	denotes	NFAT5 expression
T23528	23188-23205	Entity	denotes	cells (open bars)
T23543	23212-23215	Protein	denotes	MDM
T23521	23233-23252	Protein	denotes	with NFAT5-specific
T23561	23306-23340	Protein	denotes	MTb-induced (p = 0.021) NFAT5 mRNA
T23558	23306-23340	Protein	denotes	MTb-induced (p = 0.021) NFAT5 mRNA
T23542	23463-23466	Protein	denotes	MTb
T23567	23463-23514	Regulation	denotes	MTb co-infection when NFAT5 expression is abrogated
T23566	23480-23514	Negative_regulation	denotes	when NFAT5 expression is abrogated
T23536	23485-23490	Protein	denotes	NFAT5
T23576	23485-23501	Gene_expression	denotes	NFAT5 expression
T23526	23524-23527	Protein	denotes	MDM
T23534	23529-23556	Protein	denotes	MDM from four normal donors
T23518	23579-23593	Protein	denotes	NFAT5-specific
T23520	23633-23638	Entity	denotes	Cells
T23525	23710-23713	Protein	denotes	MTb
T23523	23849-23889	Entity	denotes	cells transfected with NFAT5-specific si
T23530	23872-23886	Protein	denotes	NFAT5-specific
T23519	23872-23889	Entity	denotes	NFAT5-specific si
T23537	23889-23892	Protein	denotes	RNA
T23559	23910-23940	Entity	denotes	cells transfected with control
T23535	23951-23952	Entity	denotes	p
T23553	23988-23996	Entity	denotes	of cells
T23517	24046-24076	Entity	denotes	noticeable macrophage necrosis
T10220	24146-24151	Protein	denotes	NFAT5
T10196	24229-24248	Entity	denotes	the reporter assays
T10242	24351-24356	Protein	denotes	NFAT5
T10251	24357-24361	Protein	denotes	mRNA
T10254	24372-24404	Regulation	denotes	MDM co-infected with a subtype B
T10198	24372-24404	Protein	denotes	MDM co-infected with a subtype B
T10222	24467-24470	Protein	denotes	MTb
T10235	24547-24609	Protein	denotes	the CCR5-tropic envelope region of HIV-1Bal (HIV-1Lai/Bal-env)
T10226	24646-24657	Protein	denotes	primary MDM
T10237	24725-24730	Protein	denotes	NF-κB
T10211	24735-24740	Protein	denotes	NFAT5
T10214	24744-24755	Protein	denotes	MTb-induced
T10243	24948-24966	Protein	denotes	Bal-Env infectious
T10208	24948-24966	Protein	denotes	Bal-Env infectious
T10213	25079-25103	Protein	denotes	of the HIV-1Bal envelope
T10249	25104-25115	Protein	denotes	co-receptor
T10212	25143-25184	Protein	denotes	the HIV-1Lai envelope co-receptor binding
T10215	25165-25176	Protein	denotes	co-receptor
T10252	25249-25253	Entity	denotes	PBMC
T10238	25306-25335	Protein	denotes	proper co-receptor engagement
T10221	25421-25426	Protein	denotes	NFAT5
T10206	25421-25522	Protein	denotes	NFAT5 mRNA levels in MDM using an siRNA that suppresses both NFAT5 mRNA and NFAT5 protein levels [31]
T10231	25442-25445	Protein	denotes	MDM
T10232	25482-25487	Protein	denotes	NFAT5
T10223	25482-25492	Protein	denotes	NFAT5 mRNA
T10234	25497-25502	Protein	denotes	NFAT5
T10241	25497-25522	Protein	denotes	NFAT5 protein levels [31]
T10239	25585-25590	Protein	denotes	NFAT5
T10248	25599-25604	Protein	denotes	NFAT5
T10250	25625-25628	Protein	denotes	MTb
T10194	25641-25645	Entity	denotes	p =
T10233	25656-25659	Protein	denotes	MTb
T10205	25670-25674	Entity	denotes	p =
T10245	25681-25684	Protein	denotes	MDM
T10210	25724-25727	Protein	denotes	GFP
T10192	25739-25742	Protein	denotes	MTb
T10218	25767-25782	Protein	denotes	MDM (Figure 2B)
T10217	25888-25928	Protein	denotes	human MDM, which are non-dividing cells,
T10229	25909-25927	Entity	denotes	non-dividing cells
T10247	26032-26035	Protein	denotes	MDM
T10246	26045-26050	Protein	denotes	NFAT5
T10201	26086-26091	Protein	denotes	NFAT5
T10202	26111-26142	Entity	denotes	transfected with control GFP si
T10199	26136-26139	Protein	denotes	GFP
T10230	26142-26145	Protein	denotes	RNA
T10244	26236-26245	Entity	denotes	the cells
T10236	26277-26280	Protein	denotes	MTb
T10228	26354-26420	Entity	denotes	supernatants from MDM transfected with NFAT5-specific siRNA or GFP
T10197	26372-26375	Protein	denotes	MDM
T10224	26393-26407	Protein	denotes	NFAT5-specific
T10203	26417-26420	Protein	denotes	GFP
T10204	26431-26454	Protein	denotes	RNA at days 6, 9 and 12
T10255	26498-26517	Negative_regulation	denotes	of NFAT5 inhibition
T10195	26501-26506	Protein	denotes	NFAT5
T10193	26521-26532	Protein	denotes	MTb-induced
T10200	26640-26669	Entity	denotes	the NFAT5 siRNA-treated cells
T10209	26644-26649	Protein	denotes	NFAT5
T10216	26682-26714	Entity	denotes	to cells treated with control si
T10219	26704-26714	Entity	denotes	control si
T10240	26714-26717	Protein	denotes	RNA
T10207	26821-26826	Protein	denotes	NFAT5
T10253	26821-26837	Gene_expression	denotes	NFAT5 expression
T10227	26891-26894	Protein	denotes	MDM
T10225	26912-26915	Protein	denotes	MTb
T12064	26918-26923	Protein	denotes	NF-κB
T12042	26928-26933	Protein	denotes	NFAT5
T12114	26928-26958	Binding	denotes	NFAT5 binding to the HIV-1 LTR
T12054	27020-27028	Protein	denotes	of NFAT5
T12073	27042-27053	Protein	denotes	MTb-induced
T12127	27099-27133	Regulation	denotes	modulation of recruitment of NFAT5
T12126	27110-27133	Binding	denotes	of recruitment of NFAT5
T12044	27125-27133	Protein	denotes	of NFAT5
T12089	27177-27192	Protein	denotes	NFAT5-regulated
T12118	27216-27237	Negative_regulation	denotes	disrupt NFAT5 binding
T12076	27224-27229	Protein	denotes	NFAT5
T12120	27224-27237	Binding	denotes	NFAT5 binding
T12077	27279-27282	Protein	denotes	MTb
T12065	27375-27383	Protein	denotes	of NFAT5
T12101	27422-27425	Protein	denotes	MTb
T12047	27573-27587	Entity	denotes	the NFAT5 site
T12085	27577-27582	Protein	denotes	NFAT5
T12097	27618-27645	Entity	denotes	the two NF-κB binding sites
T12119	27750-27772	Binding	denotes	the NFAT5 binding site
T12061	27750-27772	Entity	denotes	the NFAT5 binding site
T12062	27754-27759	Protein	denotes	NFAT5
T12079	27829-27848	Entity	denotes	the CC dinucleotide
T12072	27829-27848	Entity	denotes	the CC dinucleotide
T12075	27858-27885	Entity	denotes	the core NFAT5 binding site
T12055	27862-27866	Entity	denotes	core
T12109	27867-27872	Protein	denotes	NFAT5
T12103	27933-27944	Protein	denotes	NF-κB/NFAT5
T12050	27933-27944	Protein	denotes	NF-κB/NFAT5
T12074	27939-27944	Protein	denotes	NFAT5
T12093	28027-28032	Protein	denotes	NFAT5
T12084	28067-28084	Entity	denotes	two guanines (GG)
T12082	28095-28101	Entity	denotes	I site
T12087	28122-28129	Entity	denotes	thymine
T12048	28134-28141	Entity	denotes	adenine
T12069	28143-28145	Protein	denotes	TA
T12071	28170-28173	Protein	denotes	mut
T12099	28210-28212	Protein	denotes	TA
T12108	28223-28257	Entity	denotes	the second, more distal NF-κB site
T12068	28247-28252	Protein	denotes	NF-κB
T12102	28262-28264	Entity	denotes	II
T12059	28307-28313	Protein	denotes	II-Mut
T12058	28332-28395	Entity	denotes	a double NF-κB site mutant virus (HIV-1Lai/Bal-env-κB I+II-Mut)
T12051	28341-28346	Protein	denotes	NF-κB
T12113	28467-28498	Regulation	denotes	the HIV-1 LTR on MTb regulation
T12043	28484-28487	Protein	denotes	MTb
T25197	28544-28625	Negative_regulation	denotes	Specific disruption of NFAT5 or NF-κB binding sites in the LTR of HIV-1 subtype B
T25143	28567-28572	Protein	denotes	NFAT5
T25171	28576-28625	Entity	denotes	NF-κB binding sites in the LTR of HIV-1 subtype B
T25172	28704-28709	Protein	denotes	NF-κB
T25159	28714-28719	Protein	denotes	NFAT5
T25194	28714-28742	Binding	denotes	NFAT5 binding site mutations
T25148	28714-28742	Entity	denotes	NFAT5 binding site mutations
T25142	28839-28897	Entity	denotes	The NF-κB binding site mutants (HIV-1Lai/Bal-env-κB I-Mut,
T25145	28893-28896	Protein	denotes	Mut
T25154	28921-28924	Protein	denotes	Mut
T25196	28961-29012	Binding	denotes	NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
T25175	28961-29012	Entity	denotes	NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
T25190	29178-29198	Binding	denotes	of the NFAT5 binding
T25170	29185-29190	Protein	denotes	NFAT5
T25161	29199-29203	Entity	denotes	site
T25177	29214-29219	Protein	denotes	NFAT5
T25198	29214-29227	Binding	denotes	NFAT5 binding
T25167	29265-29270	Protein	denotes	NF-κB
T25195	29265-29324	Binding	denotes	NF-κB p50/p65 binding to the overlapping NF-κB binding site
T25180	29265-29324	Protein	denotes	NF-κB p50/p65 binding to the overlapping NF-κB binding site
T25187	29287-29324	Entity	denotes	to the overlapping NF-κB binding site
T25181	29339-29345	Protein	denotes	DNaseI
T25144	29543-29573	Protein	denotes	of recombinant NF-κB (p50/p65)
T25156	29565-29572	Protein	denotes	p50/p65
T25153	29565-29572	Protein	denotes	p50/p65
T25160	29569-29572	Protein	denotes	p65
T25185	29606-29611	Protein	denotes	NFAT5
T25179	29676-29683	Protein	denotes	DNase I
T25182	29711-29716	Protein	denotes	NF-κB
T25176	29721-29726	Protein	denotes	NFAT5
T25193	29801-29820	Binding	denotes	NF-κB binding sites
T25157	29801-29820	Protein	denotes	NF-κB binding sites
T25192	29801-29870	Negative_regulation	denotes	NF-κB binding sites effectively abrogates recombinant p50/p65 binding
T25186	29815-29820	Entity	denotes	sites
T25188	29843-29870	Binding	denotes	recombinant p50/p65 binding
T25166	29855-29862	Protein	denotes	p50/p65
T25162	29855-29862	Protein	denotes	p50/p65
T25173	29859-29862	Protein	denotes	p65
T25146	29885-29891	Protein	denotes	DNaseI
T25183	29926-29937	Entity	denotes	nucleotides
T25163	30022-30029	Protein	denotes	II-Mut,
T25164	30093-30123	Protein	denotes	of recombinant NF-κB (p50/p65)
T25158	30115-30122	Protein	denotes	p50/p65
T25149	30115-30122	Protein	denotes	p50/p65
T25174	30119-30122	Protein	denotes	p65
T25147	30189-30196	Protein	denotes	DNase I
T25155	30224-30241	Protein	denotes	recombinant NF-κB
T25150	30293-30334	Entity	denotes	of the HIV-1 subtype B NF-κB binding site
T25191	30356-30393	Positive_regulation	denotes	enhances NFAT5 binding to this region
T25165	30365-30370	Protein	denotes	NFAT5
T25189	30365-30378	Binding	denotes	NFAT5 binding
T25152	30408-30414	Protein	denotes	DNaseI
T25184	30449-30460	Entity	denotes	nucleotides
T25168	30545-30552	Protein	denotes	II-Mut,
T25169	30616-30636	Protein	denotes	of recombinant NFAT5
T25151	30701-30708	Protein	denotes	DNase I
T25178	30736-30753	Protein	denotes	recombinant NFAT5
T12124	30838-30881	Binding	denotes	NFAT5 and NF-κB p50/p65 binding to the LTR,
T12107	30854-30861	Protein	denotes	p50/p65
T12046	30854-30861	Protein	denotes	p50/p65
T12088	30858-30861	Protein	denotes	p65
T12100	30897-30917	Protein	denotes	quantitative DNase I
T12095	31025-31071	Protein	denotes	of recombinant NFAT5 or NF-κB p50/p65 proteins
T12060	31025-31071	Protein	denotes	of recombinant NFAT5 or NF-κB p50/p65 proteins
T12063	31040-31045	Protein	denotes	NFAT5
T12105	31049-31054	Protein	denotes	NF-κB
T12112	31076-31131	Binding	denotes	shown in Figure 3B, the N5-Mut LTR could not bind NFAT5	true
T12092	31100-31106	Entity	denotes	N5-Mut
T12053	31100-31106	Entity	denotes	N5-Mut
T12104	31103-31106	Protein	denotes	Mut
T12090	31126-31131	Protein	denotes	NFAT5
T12086	31175-31182	Protein	denotes	p50/p65
T12045	31175-31182	Protein	denotes	p50/p65
T12125	31175-31190	Binding	denotes	p50/p65 binding
T12121	31175-31207	Negative_regulation	denotes	p50/p65 binding was not impaired	true
T12081	31179-31182	Protein	denotes	p65
T12078	31267-31286	Entity	denotes	the GG dinucleotide
T12106	31290-31292	Protein	denotes	TA
T12094	31348-31355	Protein	denotes	p50/p65
T12066	31348-31355	Protein	denotes	p50/p65
T12116	31348-31363	Binding	denotes	p50/p65 binding
T12111	31352-31355	Protein	denotes	p65
T12056	31367-31376	Entity	denotes	each site
T12091	31465-31498	Protein	denotes	of both NF-κB sites (κB I+II-Mut)
T12067	31465-31498	Entity	denotes	of both NF-κB sites (κB I+II-Mut)
T12070	31486-31497	Protein	denotes	κB I+II-Mut
T12122	31508-31551	Negative_regulation	denotes	in abrogation of p50/p65 binding to the LTR
T12117	31522-31551	Binding	denotes	of p50/p65 binding to the LTR
T12110	31525-31532	Protein	denotes	p50/p65
T12057	31525-31532	Protein	denotes	p50/p65
T12049	31529-31532	Protein	denotes	p65
T12052	31562-31601	Protein	denotes	recombinant NFAT5 binding to the single
T12083	31606-31622	Protein	denotes	the double NF-κB
T12123	31729-31825	Negative_regulation	denotes	Thus, binding of NFAT5 or NF-κB p50/p65 to their respective motifs can be specifically disrupted		true
T12115	31735-31795	Binding	denotes	binding of NFAT5 or NF-κB p50/p65 to their respective motifs
T12096	31761-31768	Protein	denotes	p50/p65
T12080	31761-31768	Protein	denotes	p50/p65
T12098	31765-31768	Protein	denotes	p65
T13614	31873-31878	Protein	denotes	NF-κB
T13626	31883-31888	Protein	denotes	NFAT5
T13606	31934-31946	Protein	denotes	MTb-mediated
T13573	32044-32049	Protein	denotes	NF-κB
T13635	32053-32058	Protein	denotes	NFAT5
T13633	32120-32148	Entity	denotes	PBMC from four normal donors
T13609	32240-32245	Entity	denotes	cells
T13598	32268-32281	Protein	denotes	MTb (CDC1551)
T13617	32348-32351	Protein	denotes	p24
T13610	32370-32403	Entity	denotes	supernatants at days 4, 7, and 12
T13577	32517-32532	Protein	denotes	MTb-co-infected
T13588	32533-32581	Entity	denotes	cells at all timepoints examined (Figures 4A–4B)
T13657	32915-32934	Regulation	denotes	of MTb co-infection
T13612	32918-32921	Protein	denotes	MTb
T13581	32936-32939	Protein	denotes	p24
T13575	32980-32988	Entity	denotes	the PBMC
T13631	33035-33038	Protein	denotes	Mut
T13648	33238-33257	Regulation	denotes	by MTb co-infection
T13578	33241-33244	Protein	denotes	MTb
T13652	33362-33472	Regulation	denotes	of MTb co-infection, consistent with important roles for both NF-κB and NFAT5 in MTb-induced HIV-1 replication
T13616	33365-33368	Protein	denotes	MTb
T13596	33424-33429	Protein	denotes	NF-κB
T13625	33434-33439	Protein	denotes	NFAT5
T13624	33443-33454	Protein	denotes	MTb-induced
T25793	33518-33529	Protein	denotes	MTb-induced
T25803	33551-33555	Entity	denotes	PBMC
T25811	33564-33593	Binding	denotes	on binding of NFAT5 and NF-κB
T25804	33578-33583	Protein	denotes	NFAT5
T25795	33588-33593	Protein	denotes	NF-κB
T25812	33626-33661	Binding	denotes	of the NF-κB or NFAT5 binding sites
T25799	33626-33661	Entity	denotes	of the NF-κB or NFAT5 binding sites
T25806	33633-33638	Protein	denotes	NF-κB
T25791	33642-33647	Protein	denotes	NFAT5
T25808	33729-33739	Entity	denotes	human PBMC
T25798	33764-33767	Protein	denotes	MTb
T25794	33769-33797	Entity	denotes	PBMC from four normal donors
T25801	33914-33917	Protein	denotes	Mut
T25809	34032-34035	Protein	denotes	MTb
T25810	34080-34083	Protein	denotes	p24
T25807	34094-34114	Entity	denotes	culture supernatants
T25792	34191-34194	Protein	denotes	p24
T25796	34215-34245	Protein	denotes	the MTb uninfected (grey bars)
T25813	34250-34278	Regulation	denotes	MTb co-infected (black bars)
T25797	34250-34278	Protein	denotes	MTb co-infected (black bars)
T25800	34279-34283	Entity	denotes	PBMC
T25802	34429-34432	Protein	denotes	MTb
T25814	34429-34446	Regulation	denotes	MTb co-infection,
T25805	34465-34467	Entity	denotes	p<
T13636	34567-34575	Protein	denotes	of NF-κB
T13615	34580-34585	Protein	denotes	NFAT5
T13613	34594-34598	Entity	denotes	site
T13585	34608-34612	Protein	denotes	MDM,
T13605	34680-34683	Protein	denotes	MDM
T13597	34721-34732	Entity	denotes	these cells
T13621	34834-34837	Protein	denotes	Mut
T13619	34862-34865	Protein	denotes	Mut
T13643	34989-35002	Protein	denotes	MTb (CDC1551)
T13618	35038-35050	Entity	denotes	Supernatants
T13655	35190-35209	Regulation	denotes	of MTb co-infection
T13584	35193-35196	Protein	denotes	MTb
T13634	35284-35285	Entity	denotes	p
T13637	35321-35322	Entity	denotes	p
T13576	35364-35365	Entity	denotes	p
T13604	35408-35409	Entity	denotes	p
T26266	35552-35575	Entity	denotes	of NF-κB or NFAT5 sites
T26270	35555-35560	Protein	denotes	NF-κB
T26271	35564-35569	Protein	denotes	NFAT5
T26267	35596-35607	Protein	denotes	MTb-induced
T26276	35629-35632	Protein	denotes	MDM
T26263	35634-35637	Protein	denotes	MDM
T26275	35753-35756	Protein	denotes	Mut
T26269	35758-35784	Protein	denotes	HIV-1Lai/Bal-env-κB II-Mut
T26273	35919-35922	Protein	denotes	MTb
T26268	35956-35959	Protein	denotes	p24
T26265	35970-35994	Entity	denotes	the culture supernatants
T26264	36067-36070	Protein	denotes	p24
T26274	36154-36157	Protein	denotes	MTb
T26272	36187-36189	Entity	denotes	p<
T13641	36284-36288	Protein	denotes	MTb,
T13608	36289-36292	Protein	denotes	p24
T13574	36315-36324	Entity	denotes	the cells
T13611	36396-36399	Protein	denotes	B-I
T13590	36435-36438	Protein	denotes	p24
T13620	36478-36492	Entity	denotes	cells infected
T13603	36515-36522	Protein	denotes	-N5-Mut
T13586	36515-36522	Protein	denotes	-N5-Mut
T13602	36519-36522	Protein	denotes	Mut
T13630	36524-36525	Entity	denotes	p
T13639	36555-36558	Protein	denotes	p24
T13629	36712-36753	Entity	denotes	of cells with wild-type virus (Figure 5D)
T13580	36845-36849	Entity	denotes	site
T13628	36873-36884	Protein	denotes	NFAT5/NF-κB
T13627	36873-36884	Protein	denotes	NFAT5/NF-κB
T13599	36879-36884	Protein	denotes	NF-κB
T13642	36916-36919	Protein	denotes	Mut
T13622	37010-37013	Protein	denotes	p24
T13640	37076-37079	Protein	denotes	MTb
T13601	37186-37189	Protein	denotes	MTb
T13638	37217-37227	Entity	denotes	macrophage
T13649	37303-37326	Positive_regulation	denotes	the enhanced expression
T13583	37380-37385	Protein	denotes	NF-κB
T13658	37380-37458	Positive_regulation	denotes	NF-κB is efficiently activated in primary MDM in response to TLR agonists [51]
T13607	37414-37425	Protein	denotes	primary MDM
T13595	37441-37458	Entity	denotes	TLR agonists [51]
T13600	37493-37498	Protein	denotes	NFAT5
T13653	37493-37514	Gene_expression	denotes	NFAT5 gene expression
T13593	37531-37546	Entity	denotes	by TLR agonists
T13592	37548-37551	Protein	denotes	MDM
T13572	37609-37617	Protein	denotes	of NF-κB
T13587	37625-37630	Protein	denotes	NFAT5
T13654	37625-37674	Binding	denotes	NFAT5 binding site mutations on virus replication
T13645	37625-37674	Entity	denotes	NFAT5 binding site mutations on virus replication
T13589	37687-37690	Protein	denotes	MDM
T13651	37718-37737	Regulation	denotes	of MTb co-infection
T13646	37721-37724	Protein	denotes	MTb
T13579	37772-37776	Entity	denotes	PBMC
T13623	37781-37784	Protein	denotes	MDM
T13656	37781-37797	Regulation	denotes	MDM co-infection
T13650	37827-37859	Binding	denotes	the conserved NFAT5 binding site
T13647	37827-37859	Binding	denotes	the conserved NFAT5 binding site
T13632	37827-37859	Entity	denotes	the conserved NFAT5 binding site
T13594	37841-37846	Protein	denotes	NFAT5
T13582	37920-37926	Protein	denotes	by MTb
T13644	37933-37948	Entity	denotes	the NF-κB sites
T13591	37937-37942	Protein	denotes	NF-κB
T14456	37951-37956	Protein	denotes	NFAT5
T14459	38032-38035	Protein	denotes	MTb
T14477	38032-38045	Regulation	denotes	MTb infection
T14450	38135-38154	Entity	denotes	the reporter assays
T14457	38186-38214	Entity	denotes	three functional NF-κB sites
T14467	38203-38208	Protein	denotes	NF-κB
T14445	38324-38327	Protein	denotes	MTb
T14475	38324-38340	Regulation	denotes	MTb co-infection
T14449	38430-38438	Protein	denotes	of NFAT5
T14468	38442-38445	Protein	denotes	MTb
T14481	38602-38670	Binding	denotes	two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
T14472	38602-38670	Entity	denotes	two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
T14462	38606-38611	Protein	denotes	NFAT5
T14466	38641-38658	Entity	denotes	three NF-κB sites
T14471	38647-38652	Protein	denotes	NF-κB
T14479	38685-38712	Binding	denotes	the two NFAT5 binding sites
T14461	38685-38712	Entity	denotes	the two NFAT5 binding sites
T14460	38693-38698	Protein	denotes	NFAT5
T14463	38735-38750	Entity	denotes	each site to CC
T14452	38748-38750	Entity	denotes	CC
T14447	38815-38819	Entity	denotes	PBMC
T14465	38976-39015	Protein	denotes	MTb CDC1551 or left infected with virus
T14451	39155-39191	Protein	denotes	of HIV-198IN22 NFAT5-Mut (Figure 6B)
T14446	39155-39191	Protein	denotes	of HIV-198IN22 NFAT5-Mut (Figure 6B)
T14454	39217-39223	Protein	denotes	of MTb
T14464	39324-39370	Protein	denotes	HIV-198IN22 NFAT5-Mut replication (Figure 6C),
T14473	39342-39345	Protein	denotes	Mut
T14476	39399-39421	Binding	denotes	of NFAT5 binding sites
T14469	39399-39421	Entity	denotes	of NFAT5 binding sites
T14448	39402-39407	Protein	denotes	NFAT5
T14470	39491-39494	Protein	denotes	MTb
T14474	39491-39507	Regulation	denotes	MTb co-infection
T14455	39531-39561	Entity	denotes	functional NF-κB binding sites
T14480	39643-39681	Negative_regulation	denotes	disruption of NFAT5 binding to the LTR
T14478	39654-39681	Binding	denotes	of NFAT5 binding to the LTR
T14453	39657-39662	Protein	denotes	NFAT5
T14458	39723-39726	Protein	denotes	MTb
T14482	39723-39739	Regulation	denotes	MTb co-infection
T26792	39796-39813	Entity	denotes	of the NFAT5 site
T26799	39803-39808	Protein	denotes	NFAT5
T26796	39855-39866	Protein	denotes	MTb-induced
T26801	39899-39924	Binding	denotes	of the NFAT5 binding site
T26794	39899-39924	Entity	denotes	of the NFAT5 binding site
T26787	39906-39911	Protein	denotes	NFAT5
T26789	39975-39980	Protein	denotes	NFAT5
T26802	39975-40003	Binding	denotes	NFAT5 binding site mutations
T26797	39975-40003	Entity	denotes	NFAT5 binding site mutations
T26800	40062-40112	Binding	denotes	The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
T26791	40062-40112	Protein	denotes	The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
T26784	40080-40084	Entity	denotes	site
T26782	40093-40111	Entity	denotes	HIV-198IN22 N5-Mut
T26778	40093-40111	Protein	denotes	HIV-198IN22 N5-Mut
T26793	40216-40255	Entity	denotes	three NF-κB and two NFAT5 binding sites
T26779	40222-40227	Protein	denotes	NF-κB
T26781	40236-40241	Protein	denotes	NFAT5
T26795	40257-40288	Entity	denotes	The unique 3′ terminal adenine,
T26777	40308-40317	Protein	denotes	for NFAT5
T26780	40326-40338	Entity	denotes	to its site,
T26798	40442-40470	Entity	denotes	PBMC from four normal donors
T26783	40543-40548	Entity	denotes	Cells
T26790	40618-40621	Protein	denotes	MTb
T26788	40734-40764	Protein	denotes	viral p24 levels were measured
T26786	40887-40889	Entity	denotes	p<
T26785	40914-40917	Protein	denotes	MTb
T26803	40914-40930	Regulation	denotes	MTb co-infection
T16876	40975-40990	Protein	denotes	MyD88-dependent
T16873	41030-41111	Protein	denotes	the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication
T16874	41082-41093	Protein	denotes	MTb-induced
T16847	41173-41182	Entity	denotes	molecules
T16819	41224-41227	Protein	denotes	MTb
T16903	41224-41264	Positive_regulation	denotes	MTb stimulation of NFAT5 gene expression
T16904	41240-41264	Gene_expression	denotes	of NFAT5 gene expression
T16860	41243-41248	Protein	denotes	NFAT5
T16858	41307-41311	Protein	denotes	TLR2
T16889	41334-41339	Protein	denotes	NFAT5
T16879	41334-41351	Protein	denotes	NFAT5 mRNA levels
T16811	41388-41405	Protein	denotes	the TLR2-specific
T16859	41406-41413	Entity	denotes	agonist
T16883	41436-41441	Protein	denotes	NFAT5
T16831	41486-41489	Protein	denotes	Pam
T16900	41523-41549	Positive_regulation	denotes	to mock-stimulated control
T16795	41550-41567	Entity	denotes	cells (Figure 7A)
T16882	41675-41678	Protein	denotes	MTb
T16912	41675-41688	Regulation	denotes	MTb infection
T16843	41698-41715	Protein	denotes	NFAT5 mRNA levels
T16838	41704-41708	Protein	denotes	mRNA
T16914	41773-41838	Positive_regulation	denotes	that additional PRRs may be triggered during actual MTb infection		true
T16835	41778-41793	Protein	denotes	additional PRRs
T16902	41818-41838	Regulation	denotes	actual MTb infection
T16816	41825-41828	Protein	denotes	MTb
T16915	41874-41910	Gene_expression	denotes	on NFAT5 gene expression (Figure 7A)
T16825	41877-41882	Protein	denotes	NFAT5
T28310	41960-41974	Protein	denotes	MyD88-mediated
T28293	42010-42013	Protein	denotes	MTb
T28329	42024-42043	Gene_expression	denotes	of NFAT5 expression
T28286	42027-42032	Protein	denotes	NFAT5
T28309	42053-42062	Entity	denotes	monocytes
T28300	42082-42086	Protein	denotes	TLR2
T28250	42110-42115	Protein	denotes	NFAT5
T28244	42110-42130	Protein	denotes	NFAT5 mRNA synthesis
T28247	42134-42143	Entity	denotes	monocytes
T28276	42181-42194	Protein	denotes	TLR2-specific
T28294	42195-42201	Entity	denotes	ligand
T28257	42235-42238	Protein	denotes	MTb
T28296	42310-42315	Protein	denotes	NFAT5
T28291	42343-42348	Protein	denotes	NFAT5
T28260	42343-42353	Protein	denotes	NFAT5 mRNA
T28324	42343-42364	Gene_expression	denotes	NFAT5 mRNA expression
T28322	42343-42435	Positive_regulation	denotes	NFAT5 mRNA expression was significantly increased when the cells were incubated with Pam3Cys
T28277	42398-42407	Entity	denotes	the cells
T28311	42440-42441	Entity	denotes	p
T28271	42465-42468	Protein	denotes	MTb
T28284	42474-42475	Entity	denotes	p
T28245	42487-42492	Protein	denotes	MyD88
T28261	42510-42513	Protein	denotes	MTb
T28330	42524-42548	Gene_expression	denotes	of NFAT5 gene expression
T28254	42527-42532	Protein	denotes	NFAT5
T28307	42552-42567	Entity	denotes	human monocytes
T28326	42569-42684	Gene_expression	denotes	THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28325	42569-42684	Transcription	denotes	THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28285	42569-42684	Entity	denotes	THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28295	42609-42684	Protein	denotes	lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28258	42648-42653	Protein	denotes	MyD88
T28289	42648-42684	Protein	denotes	MyD88 or control shRNA targeting GFP
T28269	42681-42684	Protein	denotes	GFP
T28272	42741-42746	Entity	denotes	Cells
T28292	42766-42769	Protein	denotes	MTb
T28302	42786-42803	Entity	denotes	1∶1 cells∶bacilli
T28297	42850-42853	Protein	denotes	RNA
T28312	42868-42885	Protein	denotes	NFAT5 mRNA levels
T28256	42874-42878	Protein	denotes	mRNA
T28265	42918-43025	Entity	denotes	the cells transduced with MyD88-specific shRNA (black bars) compared with the cells transduced with control
T28280	42944-42958	Protein	denotes	MyD88-specific
T28308	42944-42977	Protein	denotes	MyD88-specific shRNA (black bars)
T28268	42987-43025	Entity	denotes	with the cells transduced with control
T28298	43026-43043	Protein	denotes	shRNA (open bars)
T28331	43077-43093	Regulation	denotes	of MTb infection
T28255	43080-43083	Protein	denotes	MTb
T28267	43095-43098	Protein	denotes	TNF
T28288	43095-43114	Protein	denotes	TNF and CD86 mRNAs,
T28264	43103-43107	Protein	denotes	CD86
T28249	43143-43158	Protein	denotes	MyD88-dependent
T28314	43198-43201	Protein	denotes	MTb
T28316	43198-43212	Regulation	denotes	MTb infection,
T28251	43247-43252	Protein	denotes	IRAK1
T28313	43257-43262	Protein	denotes	TRAF6
T28252	43280-43283	Protein	denotes	MTb
T28323	43294-43318	Gene_expression	denotes	of NFAT5 gene expression
T28278	43297-43302	Protein	denotes	NFAT5
T28279	43322-43337	Entity	denotes	human monocytes
T28320	43339-43432	Gene_expression	denotes	THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28319	43339-43432	Gene_expression	denotes	THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28318	43339-43432	Transcription	denotes	THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28275	43339-43432	Entity	denotes	THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28306	43379-43408	Protein	denotes	lentivirally-delivered IRAK1-
T28305	43412-43426	Protein	denotes	TRAF6-specific
T28246	43412-43432	Protein	denotes	TRAF6-specific shRNA
T28328	43489-43525	Transcription	denotes	THP-1 cells expressing control shRNA
T28327	43489-43525	Gene_expression	denotes	THP-1 cells expressing control shRNA
T28281	43489-43525	Entity	denotes	THP-1 cells expressing control shRNA
T28248	43512-43525	Protein	denotes	control shRNA
T28301	43556-43561	Entity	denotes	Cells
T28303	43581-43584	Protein	denotes	MTb
T28290	43645-43648	Protein	denotes	RNA
T28273	43663-43668	Protein	denotes	NFAT5
T28315	43663-43679	Gene_expression	denotes	NFAT5 expression
T28317	43663-43774	Negative_regulation	denotes	NFAT5 expression was significantly inhibited in the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
T28262	43711-43774	Protein	denotes	the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
T28263	43752-43761	Protein	denotes	IRAK1 (C)
T28304	43765-43770	Protein	denotes	TRAF6
T28259	43775-43780	Protein	denotes	shRNA
T28282	43803-43811	Entity	denotes	to cells
T28270	43831-43836	Protein	denotes	shRNA
T28299	43850-43853	Protein	denotes	TNF
T28283	43850-43868	Protein	denotes	TNF and CD86 mRNAs
T28274	43858-43862	Protein	denotes	CD86
T28253	43892-43897	Protein	denotes	IRAK1
T28287	43902-43907	Protein	denotes	TRAF6
T28321	43922-43939	Positive_regulation	denotes	by PRR activation
T28266	43925-43928	Protein	denotes	PRR
T16878	43993-44019	Entity	denotes	The adaptor molecule MyD88
T16817	43993-44019	Protein	denotes	The adaptor molecule MyD88
T16888	44043-44047	Protein	denotes	TLR2
T16863	44093-44105	Protein	denotes	this protein
T16850	44171-44174	Protein	denotes	MTb
T16891	44185-44209	Gene_expression	denotes	of NFAT5 gene expression
T16823	44188-44193	Protein	denotes	NFAT5
T16845	44274-44336	Protein	denotes	a lentivirally-delivered short hairpin (sh)RNA targeting MyD88
T16851	44331-44336	Protein	denotes	MyD88
T16854	44348-44351	Protein	denotes	PCR
T16828	44374-44389	Protein	denotes	that MyD88 mRNA
T16815	44379-44384	Protein	denotes	MyD88
T16836	44400-44411	Entity	denotes	these cells
T16887	44483-44505	Entity	denotes	THP-1 cells transduced
T16821	44543-44569	Protein	denotes	GFP shRNA (data not shown)
T16803	44571-44604	Entity	denotes	These MyD88 knockdown THP-1 cells
T16867	44577-44582	Protein	denotes	MyD88
T16800	44629-44642	Protein	denotes	MTb (CDC1551)
T16884	44647-44652	Protein	denotes	NFAT5
T16877	44647-44664	Protein	denotes	NFAT5 mRNA levels
T16802	44686-44689	Protein	denotes	TNF
T16861	44693-44732	Protein	denotes	a MyD88-dependent gene [21], [54], [55]
T16856	44695-44710	Protein	denotes	MyD88-dependent
T16826	44768-44771	Protein	denotes	TNF
T16808	44836-44878	Protein	denotes	the MyD88-independent gene CD86 [55], [56]
T16807	44836-44878	Protein	denotes	the MyD88-independent gene CD86 [55], [56]
T16804	44840-44857	Protein	denotes	MyD88-independent
T16852	44913-44921	Protein	denotes	of MyD88
T16797	44945-44956	Protein	denotes	MTb-induced
T16820	44957-44962	Protein	denotes	NFAT5
T16822	44967-44970	Protein	denotes	TNF
T16813	44967-44975	Protein	denotes	TNF mRNA
T16897	44991-45013	Regulation	denotes	no impact on CD86 mRNA
T16853	45001-45013	Protein	denotes	on CD86 mRNA
T16855	45004-45008	Protein	denotes	CD86
T16830	45028-45031	Protein	denotes	MTb
T16892	45028-45051	Regulation	denotes	MTb regulation of NFAT5
T16899	45028-45075	Regulation	denotes	MTb regulation of NFAT5 is dependent upon MyD88
T16864	45043-45051	Protein	denotes	of NFAT5
T16870	45065-45075	Protein	denotes	upon MyD88
T16906	45095-45157	Regulation	denotes	the pathway mediating MTb upregulation of NFAT5 transcription,
T16841	45117-45120	Protein	denotes	MTb
T16894	45117-45156	Positive_regulation	denotes	MTb upregulation of NFAT5 transcription
T16839	45137-45142	Protein	denotes	NFAT5
T16910	45137-45156	Transcription	denotes	NFAT5 transcription
T16834	45178-45260	Entity	denotes	THP-1 cells transduced with lentivirally-delivered shRNAs targeting IRAK1 or TRAF6
T16833	45246-45251	Protein	denotes	IRAK1
T16814	45255-45260	Protein	denotes	TRAF6
T16824	45276-45285	Entity	denotes	molecules
T16880	45300-45305	Protein	denotes	MyD88
T16886	45356-45361	Protein	denotes	IRAK1
T16799	45366-45371	Protein	denotes	TRAF6
T16917	45372-45399	Negative_regulation	denotes	significantly inhibited MTb
T16827	45372-45399	Protein	denotes	significantly inhibited MTb
T16865	45408-45413	Protein	denotes	NFAT5
T16868	45408-45425	Protein	denotes	NFAT5 mRNA levels
T16866	45440-45451	Protein	denotes	MTb-induced
T16908	45440-45471	Gene_expression	denotes	MTb-induced TNF gene expression
T16875	45452-45455	Protein	denotes	TNF
T16809	45547-45552	Protein	denotes	IRAK1
T16806	45547-45574	Protein	denotes	IRAK1 and TRAF6 in TNF gene
T16895	45547-45585	Gene_expression	denotes	IRAK1 and TRAF6 in TNF gene expression
T16862	45557-45569	Protein	denotes	TRAF6 in TNF
T16801	45566-45569	Protein	denotes	TNF
T16871	45599-45602	Protein	denotes	MTb
T16901	45599-45612	Regulation	denotes	MTb infection
T16829	45646-45650	Protein	denotes	CD86
T16916	45646-45666	Gene_expression	denotes	CD86 gene expression
T16907	45646-45703	Regulation	denotes	CD86 gene expression did not depend on MyD88 (Figure 7B),
T16818	45682-45703	Protein	denotes	on MyD88 (Figure 7B),
T16913	45704-45723	Negative_regulation	denotes	abrogation of IRAK1
T16842	45715-45723	Protein	denotes	of IRAK1
T16890	45728-45733	Protein	denotes	TRAF6
T16905	45728-45749	Gene_expression	denotes	TRAF6 gene expression
T16796	45772-45776	Protein	denotes	CD86
T16844	45772-45781	Protein	denotes	CD86 mRNA
T16805	45806-45810	Protein	denotes	CD86
T16898	45806-45821	Gene_expression	denotes	CD86 expression
T16849	45825-45831	Protein	denotes	IRAK1-
T16869	45836-45852	Protein	denotes	TRAF6-dependent,
T16798	45878-45881	Protein	denotes	MTb
T16885	45891-45916	Entity	denotes	monocytes (Figures 7C–7D)
T16909	45924-46014	Positive_regulation	denotes	together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression
T16857	45973-45976	Protein	denotes	MTb
T16893	45990-46014	Gene_expression	denotes	of NFAT5 gene expression
T16846	45993-45998	Protein	denotes	NFAT5
T16810	46034-46039	Entity	denotes	cells
T16911	46049-46068	Positive_regulation	denotes	activation of MyD88
T16881	46060-46068	Protein	denotes	of MyD88
T16812	46073-46082	Protein	denotes	the MyD88
T16872	46102-46111	Entity	denotes	molecules
T16840	46112-46117	Protein	denotes	IRAK1
T16837	46122-46127	Protein	denotes	TRAF6
T20813	46141-46171	Protein	denotes	The transcription factor NFAT5
T20812	46145-46165	Protein	denotes	transcription factor
T20874	46223-46226	Protein	denotes	Rel
T20837	46237-46250	Protein	denotes	NFAT proteins
T20869	46264-46321	Protein	denotes	the other NFAT proteins (NFATp, NFATc, NFAT3, and NFAT4),
T20780	46289-46320	Protein	denotes	NFATp, NFATc, NFAT3, and NFAT4)
T20896	46296-46301	Protein	denotes	NFATc
T20903	46303-46308	Protein	denotes	NFAT3
T20880	46314-46319	Protein	denotes	NFAT4
T20825	46322-46327	Protein	denotes	NFAT5
T20909	46322-46431	Binding	denotes	NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,
T20770	46334-46337	Entity	denotes	DNA
T20820	46341-46431	Entity	denotes	an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,
T20771	46383-46388	Protein	denotes	NF-κB
T20763	46383-46402	Protein	denotes	NF-κB proteins [58]
T20784	46407-46418	Protein	denotes	calcineurin
T20849	46455-46512	Protein	denotes	with the basic region-leucine zipper proteins Fos and Jun
T20873	46501-46504	Protein	denotes	Fos
T20877	46516-46520	Protein	denotes	gene
T20918	46516-46531	Positive_regulation	denotes	gene activation
T20907	46594-46686	Regulation	denotes	integrin activation, and T cell-stimulation have been shown to regulate NFAT5 activity [59],
T20766	46619-46637	Entity	denotes	T cell-stimulation
T20797	46666-46671	Protein	denotes	NFAT5
T20801	46771-46774	Protein	denotes	MTb
T20929	46771-46784	Regulation	denotes	MTb infection
T20875	46793-46808	Protein	denotes	MyD88-dependent
T20926	46793-46847	Positive_regulation	denotes	MyD88-dependent upregulation of NFAT5 gene expression,
T20919	46793-46847	Regulation	denotes	MyD88-dependent upregulation of NFAT5 gene expression,
T20948	46822-46846	Gene_expression	denotes	of NFAT5 gene expression
T20755	46825-46830	Protein	denotes	NFAT5
T20781	46886-46889	Protein	denotes	MTb
T20870	46952-46966	Protein	denotes	MTb-stimulated
T20936	46952-46988	Positive_regulation	denotes	MTb-stimulated HIV-1 gene expression
T20878	47005-47008	Protein	denotes	MTb
T20942	47064-47098	Binding	denotes	a direct interaction between NFAT5
T20804	47085-47098	Protein	denotes	between NFAT5
T20889	47113-47121	Entity	denotes	promoter
T20933	47123-47154	Regulation	denotes	Thus, HIV-1 has co-opted NFAT5,
T20844	47148-47154	Protein	denotes	NFAT5,
T20761	47263-47268	Protein	denotes	NF-κB
T20920	47263-47321	Positive_regulation	denotes	NF-κB is activated after MTb engagement of PRRs [20], [66]
T20800	47288-47321	Protein	denotes	MTb engagement of PRRs [20], [66]
T20786	47306-47321	Protein	denotes	PRRs [20], [66]
T20912	47323-47428	Binding	denotes	Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer
T20872	47396-47428	Protein	denotes	of the NF-κB p50/p65 heterodimer
T20762	47396-47428	Entity	denotes	of the NF-κB p50/p65 heterodimer
T20814	47403-47408	Protein	denotes	NF-κB
T20796	47486-47490	Protein	denotes	gene
T20923	47486-47504	Transcription	denotes	gene transcription
T20876	47568-47573	Protein	denotes	NF-κB
T20785	47607-47618	Entity	denotes	of histones
T20808	47649-47654	Protein	denotes	nuc-1
T20910	47705-47740	Binding	denotes	in recruitment of the pTEFb complex
T20854	47720-47740	Entity	denotes	of the pTEFb complex
T20776	47720-47740	Entity	denotes	of the pTEFb complex
T20831	47764-47767	Protein	denotes	RNA
T20851	47764-47787	Protein	denotes	RNA pol II processivity
T20788	47878-47883	Protein	denotes	NFAT5
T20897	47894-47901	Protein	denotes	p50/p65
T20840	47894-47901	Protein	denotes	p50/p65
T20839	47898-47901	Protein	denotes	p65
T20911	47954-47973	Regulation	denotes	by MTb co-infection
T20905	47957-47960	Protein	denotes	MTb
T20848	47980-47985	Protein	denotes	NF-κB
T20807	47996-48007	Entity	denotes	the nucleus
T20892	48056-48084	Entity	denotes	of the NFAT5 binding site(s)
T20921	48056-48084	Binding	denotes	of the NFAT5 binding site(s)
T20806	48063-48068	Protein	denotes	NFAT5
T20832	48088-48097	Entity	denotes	R5-tropic
T20850	48192-48196	Entity	denotes	PBMC
T20816	48200-48203	Protein	denotes	MDM
T20798	48243-48246	Protein	denotes	MTb
T20938	48330-48357	Binding	denotes	of NFAT5 binding to the LTR
T20829	48333-48338	Protein	denotes	NFAT5
T20856	48378-48381	Protein	denotes	MTb
T20908	48378-48394	Regulation	denotes	MTb co-infection
T20828	48410-48430	Entity	denotes	an intact NFAT5 site
T20789	48420-48425	Protein	denotes	NFAT5
T20836	48467-48489	Entity	denotes	of the two NF-κB sites
T20774	48478-48483	Protein	denotes	NF-κB
T20881	48527-48538	Protein	denotes	MTb-induced
T20922	48605-48624	Regulation	denotes	of MTb co-infection
T20863	48608-48611	Protein	denotes	MTb
T20823	48637-48653	Entity	denotes	of NF-κB site II
T20772	48637-48653	Entity	denotes	of NF-κB site II
T20858	48640-48645	Protein	denotes	NF-κB
T20769	48736-48783	Entity	denotes	of NF-κB site I. Consistent with these findings
T20886	48739-48744	Protein	denotes	NF-κB
T20815	48838-48853	Entity	denotes	these two sites
T20944	48900-48940	Binding	denotes	The downstream NF-κB site I binding site
T20846	48900-48940	Entity	denotes	The downstream NF-κB site I binding site
T20810	48900-48940	Entity	denotes	The downstream NF-κB site I binding site
T20792	48900-48940	Protein	denotes	The downstream NF-κB site I binding site
T20939	48998-49012	Binding	denotes	binding sites,
T20782	48998-49012	Entity	denotes	binding sites,
T20941	49021-49075	Positive_regulation	denotes	to enhance Sp protein recruitment to the LTR [71]–[73]
T20833	49035-49042	Protein	denotes	protein
T20945	49035-49075	Binding	denotes	protein recruitment to the LTR [71]–[73]
T20893	49085-49090	Protein	denotes	NF-κB
T20866	49085-49097	Entity	denotes	NF-κB site I
T20890	49107-49116	Protein	denotes	the NFAT5
T20778	49125-49129	Entity	denotes	site
T20764	49176-49185	Entity	denotes	this site
T20853	49221-49236	Protein	denotes	increased NFAT5
T20891	49245-49264	Entity	denotes	to the mutated site
T20927	49296-49392	Negative_regulation	denotes	with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
T20867	49305-49325	Protein	denotes	quantitative DNase I
T20783	49384-49392	Protein	denotes	of NF-κB
T20817	49393-49399	Entity	denotes	site I
T20928	49408-49447	Positive_regulation	denotes	in enhanced binding of NFAT5 to the LTR
T20916	49408-49447	Binding	denotes	in enhanced binding of NFAT5 to the LTR
T20894	49428-49436	Protein	denotes	of NFAT5
T20765	49579-49614	Protein	denotes	of endemic TB [1], [2], [28], [52],
T20775	49653-49678	Entity	denotes	three NF-κB binding sites
T20843	49709-49715	Protein	denotes	of MTb
T20790	50043-50070	Protein	denotes	reporter gene transcription
T20852	50207-50210	Protein	denotes	MTb
T20835	50274-50297	Entity	denotes	peripheral blood cells,
T20915	50298-50359	Negative_regulation	denotes	we found that specific disruption of NFAT5 binding to the LTR
T20932	50332-50359	Binding	denotes	of NFAT5 binding to the LTR
T20826	50335-50340	Protein	denotes	NFAT5
T20862	50408-50411	Protein	denotes	MTb
T20937	50408-50425	Regulation	denotes	MTb co-infection,
T20883	50460-50496	Protein	denotes	of three intact NF-κB binding sites,
T20934	50576-50596	Binding	denotes	of NFAT5 recruitment
T20884	50579-50584	Protein	denotes	NFAT5
T20802	50629-50635	Protein	denotes	of MTb
T20787	50665-50670	Protein	denotes	NF-κB
T20803	50675-50680	Protein	denotes	NFAT5
T20855	50712-50717	Protein	denotes	NF-κB
T20868	50722-50727	Protein	denotes	NFAT5
T20756	50767-50782	Entity	denotes	site in the LTR
T20904	50827-50830	Protein	denotes	MTb
T20906	50827-50840	Regulation	denotes	MTb infection
T20895	50850-50855	Protein	denotes	NFAT5
T20865	50963-50985	Protein	denotes	the host factors NF-κB
T20914	50963-51044	Binding	denotes	the host factors NF-κB and NFAT5 associate with the LTR at different stages after
T20913	50963-51044	Binding	denotes	the host factors NF-κB and NFAT5 associate with the LTR at different stages after
T20847	50990-50995	Protein	denotes	NFAT5
T20822	51069-51074	Protein	denotes	NF-κB
T20882	51087-51098	Entity	denotes	the nucleus
T20799	51126-51129	Protein	denotes	MTb
T20924	51126-51151	Regulation	denotes	MTb infection [74], [75],
T20824	51152-51157	Protein	denotes	NFAT5
T20899	51181-51261	Protein	denotes	NFAT5, which is pivotal for HIV-1 transcription in unstimulated cells [31], may,
T20827	51232-51255	Entity	denotes	unstimulated cells [31]
T20838	51268-51271	Protein	denotes	Mtb
T20940	51268-51282	Regulation	denotes	Mtb infection,
T20900	51336-51341	Protein	denotes	NF-κB
T20821	51352-51355	Protein	denotes	Tat
T20885	51474-51479	Protein	denotes	NFAT5
T20925	51474-51585	Binding	denotes	NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
T20759	51486-51523	Entity	denotes	to the aldose reductase (AR) promoter
T20818	51493-51514	Protein	denotes	aldose reductase (AR)
T20861	51511-51513	Protein	denotes	AR
T20888	51562-51573	Protein	denotes	histones H3
T20841	51644-51665	Entity	denotes	duct epithelial cells
T20777	51677-51682	Protein	denotes	NFAT5
T20767	51687-51700	Entity	denotes	NF-κB complex
T20753	51714-51729	Protein	denotes	NF-κB-dependent
T20805	51714-51734	Protein	denotes	NF-κB-dependent gene
T20898	51735-51749	Entity	denotes	promoters [77]
T20793	51797-51802	Protein	denotes	NFAT5
T20773	51847-51854	Entity	denotes	histone
T20757	51886-51894	Protein	denotes	to NF-κB
T20931	51929-51987	Binding	denotes	by directly interacting with NF-κB in a cooperative manner
T20857	51953-51963	Protein	denotes	with NF-κB
T20871	52025-52035	Protein	denotes	that NFAT5
T20809	52135-52160	Protein	denotes	MTb-co-infection of human
T20794	52161-52165	Entity	denotes	PBMC
T20879	52170-52173	Protein	denotes	MDM
T20943	52175-52222	Binding	denotes	Functional NF-κB interaction with the viral LTR
T20791	52186-52191	Protein	denotes	NF-κB
T20949	52319-52339	Binding	denotes	of NFAT5 recruitment
T20859	52322-52327	Protein	denotes	NFAT5
T20860	52343-52361	Entity	denotes	the viral promoter
T20946	52397-52415	Regulation	denotes	that MTb infection
T20901	52402-52405	Protein	denotes	MTb
T20864	52436-52451	Entity	denotes	the TLR2 ligand
T20819	52440-52444	Protein	denotes	TLR2
T20834	52469-52474	Protein	denotes	NFAT5
T20947	52469-52490	Gene_expression	denotes	NFAT5 gene expression
T20811	52494-52509	Entity	denotes	human monocytes
T20935	52524-52567	Positive_regulation	denotes	we have shown that MTb stimulation of NFAT5
T20845	52543-52546	Protein	denotes	MTb
T20795	52562-52567	Protein	denotes	NFAT5
T20842	52601-52610	Entity	denotes	molecules
T20779	52622-52635	Protein	denotes	MyD88, IRAK1,
T20754	52629-52634	Protein	denotes	IRAK1
T20768	52640-52645	Protein	denotes	TRAF6
T20760	52758-52761	Protein	denotes	MTb
T20917	52758-52771	Regulation	denotes	MTb infection
T20887	52788-52793	Protein	denotes	NFAT5
T20758	52867-52871	Protein	denotes	gene
T20930	52867-52882	Regulation	denotes	gene regulation
T20830	52922-52941	Protein	denotes	TLR-regulated genes
T20902	52996-52999	Protein	denotes	MTb
R10130	T13578	T13648	themeOf	MTb,by MTb co-infection
R10131	T13583	T13658	themeOf	NF-κB,NF-κB is efficiently activated in primary MDM in response to TLR agonists [51]
R10132	T13584	T13655	themeOf	MTb,of MTb co-infection
R10133	T13594	T13650	themeOf	NFAT5,the conserved NFAT5 binding site
R10134	T13600	T13653	themeOf	NFAT5,NFAT5 gene expression
R10135	T13612	T13657	themeOf	MTb,of MTb co-infection
R10136	T13616	T13652	themeOf	MTb,"of MTb co-infection, consistent with important roles for both NF-κB and NFAT5 in MTb-induced HIV-1 replication"
R10137	T13623	T13656	themeOf	MDM,MDM co-infection
R10138	T13632	T13647	themeOf	the conserved NFAT5 binding site,the conserved NFAT5 binding site
R10139	T13646	T13651	themeOf	MTb,of MTb co-infection
R10803	T14445	T14475	themeOf	MTb,MTb co-infection
R10804	T14453	T14478	themeOf	NFAT5,of NFAT5 binding to the LTR
R10805	T14458	T14482	themeOf	MTb,MTb co-infection
R10806	T14459	T14477	themeOf	MTb,MTb infection
R10807	T14461	T14479	themeOf	the two NFAT5 binding sites,the two NFAT5 binding sites
R10808	T14469	T14476	themeOf	of NFAT5 binding sites,of NFAT5 binding sites
R10809	T14470	T14474	themeOf	MTb,MTb co-infection
R10810	T14472	T14481	themeOf	two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A),two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
R10811	T14478	T14480	themeOf	of NFAT5 binding to the LTR,disruption of NFAT5 binding to the LTR
R12431	T16805	T16898	themeOf	CD86,CD86 expression
R12432	T16806	T16895	themeOf	IRAK1 and TRAF6 in TNF gene,IRAK1 and TRAF6 in TNF gene expression
R12433	T16816	T16902	themeOf	MTb,actual MTb infection
R12434	T16818	T16907	causeOf	"on MyD88 (Figure 7B),","CD86 gene expression did not depend on MyD88 (Figure 7B),"
R12435	T16819	T16903	causeOf	MTb,MTb stimulation of NFAT5 gene expression
R12436	T16823	T16891	themeOf	NFAT5,of NFAT5 gene expression
R12437	T16825	T16915	themeOf	NFAT5,on NFAT5 gene expression (Figure 7A)
R12438	T16827	T16917	themeOf	significantly inhibited MTb,significantly inhibited MTb
R12439	T16829	T16916	themeOf	CD86,CD86 gene expression
R12440	T16830	T16892	causeOf	MTb,MTb regulation of NFAT5
R12441	T16835	T16914	themeOf	additional PRRs,that additional PRRs may be triggered during actual MTb infection
R12442	T16839	T16910	themeOf	NFAT5,NFAT5 transcription
R12443	T16841	T16894	themeOf	MTb,MTb upregulation of NFAT5 transcription
R12444	T16842	T16913	themeOf	of IRAK1,abrogation of IRAK1
R12445	T16846	T16893	themeOf	NFAT5,of NFAT5 gene expression
R12446	T16848	T16896	themeOf	NFAT5,NFAT5 gene expression
R12447	T16853	T16897	themeOf	on CD86 mRNA,no impact on CD86 mRNA
R12448	T16857	T16909	causeOf	MTb,"together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression"
R12449	T16860	T16904	themeOf	NFAT5,of NFAT5 gene expression
R12450	T16864	T16892	themeOf	of NFAT5,MTb regulation of NFAT5
R12451	T16870	T16899	causeOf	upon MyD88,MTb regulation of NFAT5 is dependent upon MyD88
R12452	T16871	T16901	themeOf	MTb,MTb infection
R12453	T16875	T16908	themeOf	TNF,MTb-induced TNF gene expression
R12454	T16881	T16911	themeOf	of MyD88,activation of MyD88
R12455	T16882	T16912	themeOf	MTb,MTb infection
R12456	T16890	T16905	themeOf	TRAF6,TRAF6 gene expression
R12457	T16892	T16899	themeOf	MTb regulation of NFAT5,MTb regulation of NFAT5 is dependent upon MyD88
R12458	T16893	T16909	themeOf	of NFAT5 gene expression,"together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression"
R12459	T16894	T16906	themeOf	MTb upregulation of NFAT5 transcription,"the pathway mediating MTb upregulation of NFAT5 transcription,"
R12460	T16904	T16903	themeOf	of NFAT5 gene expression,MTb stimulation of NFAT5 gene expression
R12461	T16916	T16907	themeOf	CD86 gene expression,"CD86 gene expression did not depend on MyD88 (Figure 7B),"
R15368	T20755	T20948	themeOf	NFAT5,of NFAT5 gene expression
R15369	T20758	T20930	themeOf	gene,gene regulation
R15370	T20759	T20818	partOf	to the aldose reductase (AR) promoter,aldose reductase (AR)
R15372	T20759	T20925	themeOf	to the aldose reductase (AR) promoter,NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
R15373	T20760	T20917	themeOf	MTb,MTb infection
R15374	T20761	T20920	themeOf	NF-κB,"NF-κB is activated after MTb engagement of PRRs [20], [66]"
R15376	T20762	T20912	themeOf	of the NF-κB p50/p65 heterodimer,Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer
R15381	T20770	T20909	themeOf	DNA,"NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,"
R15392	T20776	T20910	themeOf	of the pTEFb complex,in recruitment of the pTEFb complex
R15402	T20782	T20939	themeOf	"binding sites,","binding sites,"
R15410	T20783	T20927	themeOf	of NF-κB,with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
R15412	T20791	T20943	themeOf	NF-κB,Functional NF-κB interaction with the viral LTR
R15415	T20796	T20923	themeOf	gene,gene transcription
R15418	T20799	T20924	themeOf	MTb,"MTb infection [74], [75],"
R15420	T20801	T20929	themeOf	MTb,MTb infection
R15421	T20804	T20942	themeOf	between NFAT5,a direct interaction between NFAT5
R15424	T20825	T20909	themeOf	NFAT5,"NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,"
R15425	T20833	T20945	themeOf	protein,protein recruitment to the LTR [71]–[73]
R15426	T20834	T20947	themeOf	NFAT5,NFAT5 gene expression
R15427	T20838	T20940	themeOf	Mtb,"Mtb infection,"
R15428	T20826	T20932	themeOf	NFAT5,of NFAT5 binding to the LTR
R15429	T20829	T20938	themeOf	NFAT5,of NFAT5 binding to the LTR
R15430	T20844	T20933	themeOf	"NFAT5,","Thus, HIV-1 has co-opted NFAT5,"
R15431	T20845	T20935	themeOf	MTb,we have shown that MTb stimulation of NFAT5
R15432	T20945	T20941	themeOf	protein recruitment to the LTR [71]–[73],to enhance Sp protein recruitment to the LTR [71]–[73]
R15433	T20846	T20944	themeOf	The downstream NF-κB site I binding site,The downstream NF-κB site I binding site
R15434	T20847	T20913	themeOf	NFAT5,the host factors NF-κB and NFAT5 associate with the LTR at different stages after
R15435	T20856	T20908	themeOf	MTb,MTb co-infection
R15436	T20857	T20931	themeOf	with NF-κB,by directly interacting with NF-κB in a cooperative manner
R15437	T20859	T20949	themeOf	NFAT5,of NFAT5 recruitment
R15438	T20862	T20937	themeOf	MTb,"MTb co-infection,"
R15439	T20863	T20922	themeOf	MTb,of MTb co-infection
R15440	T20948	T20926	themeOf	of NFAT5 gene expression,"MyD88-dependent upregulation of NFAT5 gene expression,"
R15441	T20865	T20914	themeOf	the host factors NF-κB,the host factors NF-κB and NFAT5 associate with the LTR at different stages after
R15442	T20867	T20927	causeOf	quantitative DNase I,with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
R15443	T20870	T20936	causeOf	MTb-stimulated,MTb-stimulated HIV-1 gene expression
R15444	T20875	T20919	causeOf	MyD88-dependent,"MyD88-dependent upregulation of NFAT5 gene expression,"
R15445	T20877	T20918	themeOf	gene,gene activation
R15446	T20884	T20934	themeOf	NFAT5,of NFAT5 recruitment
R15447	T20885	T20925	themeOf	NFAT5,NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
R15448	T20892	T20921	themeOf	of the NFAT5 binding site(s),of the NFAT5 binding site(s)
R15449	T20894	T20916	themeOf	of NFAT5,in enhanced binding of NFAT5 to the LTR
R15450	T20901	T20946	themeOf	MTb,that MTb infection
R15451	T20904	T20906	themeOf	MTb,MTb infection
R15452	T20905	T20911	themeOf	MTb,by MTb co-infection
R15453	T20916	T20928	themeOf	in enhanced binding of NFAT5 to the LTR,in enhanced binding of NFAT5 to the LTR
R15454	T20926	T20919	themeOf	"MyD88-dependent upregulation of NFAT5 gene expression,","MyD88-dependent upregulation of NFAT5 gene expression,"
R15455	T20932	T20915	themeOf	of NFAT5 binding to the LTR,we found that specific disruption of NFAT5 binding to the LTR
R16544	T22260	T22307	themeOf	of the NFAT5 binding site,of the NFAT5 binding site
R16545	T22261	T22303	themeOf	NFAT5,NFAT5 interaction with the LTR
R16546	T22265	T22305	themeOf	gene,Specific disruption of the NFAT5 binding site significantly reduces LTR-reporter gene activity in monocytic cells in response to MTb lysate treatment
R16547	T22273	T22308	themeOf	of NFAT5,Disruption of NFAT5 binding
R16548	T22278	T22304	themeOf	luciferase,Renilla luciferase control expression
R16549	T22284	T22306	themeOf	MTb,MTb stimulation
R17513	T23515	T23570	themeOf	MTb,MTb infection
R17514	T23536	T23576	themeOf	NFAT5,NFAT5 expression
R17515	T23542	T23567	themeOf	MTb,MTb co-infection when NFAT5 expression is abrogated
R17516	T23546	T23569	themeOf	NFAT5,NFAT5 expression in MDM
R17517	T23548	T23572	themeOf	NFAT5,NFAT5 gene expression
R17518	T23552	T23575	themeOf	MTb,MTb co-infection
R17519	T23554	T23574	themeOf	MTb,of MTb co-infection
R17520	T23557	T23565	themeOf	NFAT5,NFAT5 expression
R17521	T23565	T23568	themeOf	NFAT5 expression,MTb infection significantly increased NFAT5 expression in comparison to uninfected
R17522	T23569	T23573	themeOf	NFAT5 expression in MDM,effectively suppresses NFAT5 expression in MDM in both the absence and presence of MTb co-infection
R17523	T23570	T23568	causeOf	MTb infection,MTb infection significantly increased NFAT5 expression in comparison to uninfected
R17524	T23576	T23566	themeOf	NFAT5 expression,when NFAT5 expression is abrogated
R18435	T25143	T25197	themeOf	NFAT5,Specific disruption of NFAT5 or NF-κB binding sites in the LTR of HIV-1 subtype B
R18436	T25157	T25192	causeOf	NF-κB binding sites,NF-κB binding sites effectively abrogates recombinant p50/p65 binding
R18437	T25157	T25193	themeOf	NF-κB binding sites,NF-κB binding sites
R18438	T25162	T25188	themeOf	p50/p65,recombinant p50/p65 binding
R18439	T25165	T25189	themeOf	NFAT5,NFAT5 binding
R18440	T25170	T25190	themeOf	NFAT5,of the NFAT5 binding
R18441	T25175	T25196	themeOf	NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut),NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
R18442	T25177	T25198	themeOf	NFAT5,NFAT5 binding
R18443	T25180	T25195	themeOf	NF-κB p50/p65 binding to the overlapping NF-κB binding site,NF-κB p50/p65 binding to the overlapping NF-κB binding site
R18444	T25188	T25192	themeOf	recombinant p50/p65 binding,NF-κB binding sites effectively abrogates recombinant p50/p65 binding
R18445	T25189	T25191	themeOf	NFAT5 binding,enhances NFAT5 binding to this region
R18838	T25795	T25811	themeOf	NF-κB,on binding of NFAT5 and NF-κB
R18839	T25797	T25813	themeOf	MTb co-infected (black bars),MTb co-infected (black bars)
R18840	T25799	T25812	themeOf	of the NF-κB or NFAT5 binding sites,of the NF-κB or NFAT5 binding sites
R18841	T25802	T25814	themeOf	MTb,"MTb co-infection,"
R18842	T25804	T25811	themeOf	NFAT5,on binding of NFAT5 and NF-κB
R19550	T26785	T26803	themeOf	MTb,MTb co-infection
R19551	T26791	T26800	themeOf	The NFAT5 binding site mutant (HIV-198IN22 N5-Mut),The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
R19552	T26794	T26801	themeOf	of the NFAT5 binding site,of the NFAT5 binding site
R20606	T28246	T28318	themeOf	TRAF6-specific shRNA,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20607	T28246	T28319	themeOf	TRAF6-specific shRNA,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20608	T28248	T28327	themeOf	control shRNA,THP-1 cells expressing control shRNA
R20609	T28248	T28328	themeOf	control shRNA,THP-1 cells expressing control shRNA
R20610	T28254	T28330	themeOf	NFAT5,of NFAT5 gene expression
R20611	T28255	T28331	themeOf	MTb,of MTb infection
R20612	T28260	T28324	themeOf	NFAT5 mRNA,NFAT5 mRNA expression
R20613	T28266	T28321	themeOf	PRR,by PRR activation
R20614	T28273	T28315	themeOf	NFAT5,NFAT5 expression
R20615	T28278	T28323	themeOf	NFAT5,of NFAT5 gene expression
R20616	T28286	T28329	themeOf	NFAT5,of NFAT5 expression
R20617	T28295	T28325	themeOf	lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP,THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
R20618	T28295	T28326	themeOf	lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP,THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
R20619	T28306	T28320	themeOf	lentivirally-delivered IRAK1-,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20620	T28314	T28316	themeOf	MTb,"MTb infection,"
R20621	T28315	T28317	themeOf	NFAT5 expression,NFAT5 expression was significantly inhibited in the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
R20622	T28324	T28322	themeOf	NFAT5 mRNA expression,NFAT5 mRNA expression was significantly increased when the cells were incubated with Pam3Cys
R2107	T2697	T2785	locationOf	monocytic cells,The primary PRR on monocytic cells triggered by MTb infection
R2120	T2703	T2782	themeOf	IκB kinase (IKK) and mitogen-activated protein (MAP) kinases,TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
R2134	T2707	T2787	causeOf	mitogen-activated,mitogen-activated protein (MAP)
R2142	T2714	T2778	themeOf	MTb,by MTb infection
R2143	T2721	T2780	themeOf	MTb,MTb infection
R2144	T2723	T2773	themeOf	NFAT5,of NFAT5 expression
R2145	T2725	T2779	locationOf	core,the core NF-κB binding motifs in the LTR
R2146	T2726	T2775	causeOf	MyD88,"MyD88 signaling, [32],"
R2147	T2729	T2776	themeOf	of specific transcription factor,activation of specific transcription factor
R2148	T2730	T2784	themeOf	"several kinases, including IRAK1 and IRAK4,","the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6"
R2149	T2739	T2782	causeOf	TRAF6,TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
R2150	T2742	T2783	themeOf	"NF-κB binding sites, respectively [1], [28]","NF-κB binding sites, respectively [1], [28]"
R2151	T2753	T2787	themeOf	mitogen-activated protein (MAP),mitogen-activated protein (MAP)
R2152	T2759	T2786	themeOf	MTb,MTb infection
R2153	T2760	T2779	themeOf	the core NF-κB binding motifs in the LTR,the core NF-κB binding motifs in the LTR
R2154	T2761	T2781	themeOf	MTb,"of latent MTb reactivation,"
R2155	T2764	T2784	themeOf	the ubiquitin ligase TRAF6,"the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6"
R2156	T2767	T2774	themeOf	NFAT5,NFAT5 gene expression in human monocytes
R2157	T2769	T2777	themeOf	The primary PRR on monocytic cells triggered by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2158	T2769	T2785	themeOf	The primary PRR on monocytic cells triggered by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2159	T2774	T2772	themeOf	NFAT5 gene expression in human monocytes,we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
R2160	T2778	T2777	causeOf	by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2161	T2780	T2772	causeOf	MTb infection,we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
R3390	T4295	T4301	themeOf	Recombinant p50,Recombinant p50 and p65 were purchased
R3391	T4296	T4301	themeOf	p65,Recombinant p50 and p65 were purchased
R3971	T5029	T5034	themeOf	NFAT5,NFAT5 expression
R4408	T5569	T5591	themeOf	shRNA,Stable THP-1 cells expressing shRNA
R4409	T5569	T5592	themeOf	shRNA,Stable THP-1 cells expressing shRNA
R454	T811	T819	themeOf	MTb-mediated control of gene expression,MTb-mediated control of gene expression
R455	T812	T813	themeOf	of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R456	T815	T814	themeOf	interaction with the viral promoter,in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
R457	T817	T820	themeOf	MTb-induced NFAT5 gene expression,"MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R4770	T5981	T5984	themeOf	of primary MDM,infection of primary MDM
R5355	T6672	T6673	themeOf	mRNA,The mRNA expression levels
R5356	T6672	T6674	themeOf	mRNA,The mRNA expression levels
R5840	T7242	T7250	themeOf	to the firefly luciferase reporter gene,linked to the firefly luciferase reporter gene
R5841	T7249	T7251	themeOf	MTb,of MTb stimulation
R596	T779	T822	themeOf	MTb,MTb infection
R597	T781	T820	causeOf	"MyD88, IRAK1, and TRAF6,","MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R598	T785	T815	themeOf	with the viral promoter,interaction with the viral promoter
R599	T789	T819	causeOf	MTb-mediated,MTb-mediated control of gene expression
R600	T790	T823	themeOf	an intact NFAT5 binding site,an intact NFAT5 binding site
R601	T793	T818	themeOf	protein,protein expression
R602	T794	T817	themeOf	NFAT5,MTb-induced NFAT5 gene expression
R603	T795	T812	themeOf	of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R604	T795	T821	themeOf	of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R605	T797	T821	causeOf	nuclear factor of activated T cells 5 (NFAT5),of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R606	T806	T816	themeOf	protein,protein expression
R6466	T8050	T8075	themeOf	of NF-κB unperturbed,binding of NF-κB unperturbed [31]
R6467	T8051	T8078	themeOf	the NFAT5 binding site,the NFAT5 binding site
R6468	T8064	T8080	themeOf	of the NFAT5 binding site-mutant,of the NFAT5 binding site-mutant
R6469	T8065	T8076	themeOf	of NFAT5,the binding of NFAT5
R6470	T8069	T8079	themeOf	NFAT5,NFAT5 expression
R6471	T8070	T8077	themeOf	MTb,MTb stimulation
R6472	T8079	T8081	themeOf	NFAT5 expression,MTb lysate stimulation directly enhances NFAT5 expression
R6979	T8712	T8742	causeOf	MTb,"Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM"
R6980	T8714	T8743	themeOf	NFAT5 mRNA,NFAT5 mRNA expression
R6981	T8715	T8740	themeOf	MDM,infecting MDM with live or heat-inactivated R5-tropic
R6982	T8717	T8738	themeOf	NFAT5,NFAT5 gene expression levels by quantitative real-time PCR at 24 and 48 hours
R6983	T8723	T8741	themeOf	NFAT5 mRNA,NFAT5 mRNA expression
R6984	T8741	T8742	themeOf	NFAT5 mRNA expression,"Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM"
R6985	T8743	T8739	themeOf	NFAT5 mRNA expression,to directly enhance NFAT5 mRNA expression in primary human MDM
R8059	T10195	T10255	themeOf	NFAT5,of NFAT5 inhibition
R8060	T10198	T10254	themeOf	MDM co-infected with a subtype B,MDM co-infected with a subtype B
R8061	T10207	T10253	themeOf	NFAT5,NFAT5 expression
R9344	T12042	T12114	themeOf	NFAT5,NFAT5 binding to the HIV-1 LTR
R9345	T12043	T12113	themeOf	MTb,the HIV-1 LTR on MTb regulation
R9346	T12044	T12126	themeOf	of NFAT5,of recruitment of NFAT5
R9347	T12057	T12117	themeOf	p50/p65,of p50/p65 binding to the LTR
R9348	T12061	T12119	themeOf	the NFAT5 binding site,the NFAT5 binding site
R9349	T12076	T12120	themeOf	NFAT5,NFAT5 binding
R9350	T12080	T12115	themeOf	p50/p65,binding of NFAT5 or NF-κB p50/p65 to their respective motifs
R9351	T12086	T12125	themeOf	p50/p65,p50/p65 binding
R9352	T12090	T12112	themeOf	NFAT5,"shown in Figure 3B, the N5-Mut LTR could not bind NFAT5"
R9353	T12094	T12116	themeOf	p50/p65,p50/p65 binding
R9354	T12107	T12124	themeOf	p50/p65,"NFAT5 and NF-κB p50/p65 binding to the LTR,"
R9355	T12115	T12123	themeOf	binding of NFAT5 or NF-κB p50/p65 to their respective motifs,"Thus, binding of NFAT5 or NF-κB p50/p65 to their respective motifs can be specifically disrupted"
R9356	T12117	T12122	themeOf	of p50/p65 binding to the LTR,in abrogation of p50/p65 binding to the LTR
R9357	T12120	T12118	themeOf	NFAT5 binding,disrupt NFAT5 binding
R9358	T12125	T12121	themeOf	p50/p65 binding,p50/p65 binding was not impaired
R9359	T12126	T12127	themeOf	of recruitment of NFAT5,modulation of recruitment of NFAT5

PMC:3320587 JSONTXT 30 Projects

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PMC:3320587 JSON TXT 30 Projects