bionlp-st-ge-2016-test-ihmc  

PMC:3320587 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Negation Speculation
T805 94-99 Protein denotes NFAT5
T798 103-125 Protein denotes the Toll-Like Receptor
T813 421-578 Negative_regulation denotes we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T812 451-578 Gene_expression denotes of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T821 469-578 Negative_regulation denotes of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T795 469-578 Protein denotes of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T797 497-542 Protein denotes nuclear factor of activated T cells 5 (NFAT5)
T803 536-541 Protein denotes NFAT5
T804 607-610 Protein denotes MTb
T786 644-667 Entity denotes co-infected macrophages
T800 682-687 Protein denotes NFAT5
T809 682-692 Protein denotes NFAT5 gene
T806 697-704 Protein denotes protein
T816 697-715 Gene_expression denotes protein expression
T810 737-743 Protein denotes by MTb
T796 756-780 Protein denotes Toll-like receptor (TLR)
T780 756-788 Entity denotes Toll-like receptor (TLR) ligand,
T823 798-826 Binding denotes an intact NFAT5 binding site
T790 798-826 Entity denotes an intact NFAT5 binding site
T788 808-813 Protein denotes NFAT5
T782 830-875 Entity denotes the viral promoter of R5-tropic HIV-1 subtype
T787 965-971 Protein denotes by MTb
T791 1044-1060 Entity denotes human monocytes,
T808 1096-1105 Entity denotes molecules
T781 1106-1130 Protein denotes MyD88, IRAK1, and TRAF6,
T820 1106-1187 Negative_regulation denotes MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression
T792 1113-1119 Protein denotes IRAK1,
T802 1124-1129 Protein denotes TRAF6
T801 1154-1165 Protein denotes MTb-induced
T817 1154-1187 Gene_expression denotes MTb-induced NFAT5 gene expression
T794 1166-1171 Protein denotes NFAT5
T779 1225-1228 Protein denotes MTb
T822 1225-1238 Regulation denotes MTb infection
T778 1247-1252 Protein denotes NFAT5
T784 1247-1257 Protein denotes NFAT5 gene
T793 1262-1269 Protein denotes protein
T818 1262-1280 Gene_expression denotes protein expression
T799 1286-1291 Protein denotes NFAT5
T814 1313-1400 Regulation denotes in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
T783 1316-1319 Protein denotes MTb
T815 1365-1400 Binding denotes interaction with the viral promoter
T785 1377-1400 Entity denotes with the viral promoter
T807 1453-1458 Protein denotes NFAT5
T789 1471-1483 Protein denotes MTb-mediated
T819 1471-1510 Regulation denotes MTb-mediated control of gene expression
T811 1471-1510 Regulation denotes MTb-mediated control of gene expression
T2713 2529-2532 Protein denotes MTb
T2709 2654-2697 Protein denotes human immunodeficiency virus type 1 (HIV-1)
T2762 2738-2766 Protein denotes recognition receptors (PRRs)
T2768 2761-2765 Protein denotes PRRs
T2727 2770-2773 Protein denotes MTb
T2746 2777-2799 Entity denotes mononuclear phagocytes
T2765 2931-2940 Protein denotes cytokines
T2705 2945-2964 Protein denotes chemokines produced
T2759 2998-3001 Protein denotes MTb
T2786 2998-3011 Regulation denotes MTb infection
T2754 3053-3056 Protein denotes CD4
T2748 3053-3064 Entity denotes CD4 T cells
T2716 3079-3084 Entity denotes cells
T2698 3200-3211 Protein denotes MTb-induced
T2758 3284-3287 Protein denotes CD4
T2718 3284-3294 Entity denotes CD4 T cell
T2781 3456-3483 Positive_regulation denotes of latent MTb reactivation,
T2761 3466-3469 Protein denotes MTb
T2777 3574-3635 Positive_regulation denotes The primary PRR on monocytic cells triggered by MTb infection
T2769 3574-3635 Protein denotes The primary PRR on monocytic cells triggered by MTb infection
T2785 3574-3636 Localization denotes The primary PRR on monocytic cells triggered by MTb infection
T2697 3593-3608 Entity denotes monocytic cells
T2778 3619-3635 Regulation denotes by MTb infection
T2714 3622-3625 Protein denotes MTb
T2719 3639-3670 Protein denotes toll-like receptor (TLR) 2 [16]
T2737 3691-3695 Protein denotes TLR2
T2751 3733-3855 Protein denotes protein MyD88 and the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6
T2699 3741-3746 Protein denotes MyD88
T2784 3751-3855 Binding denotes the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6
T2730 3781-3824 Protein denotes several kinases, including IRAK1 and IRAK4,
T2710 3808-3813 Protein denotes IRAK1
T2728 3818-3823 Protein denotes IRAK4
T2764 3829-3855 Protein denotes the ubiquitin ligase TRAF6
T2708 3829-3855 Protein denotes the ubiquitin ligase TRAF6
T2738 3833-3842 Protein denotes ubiquitin
T2739 3893-3898 Protein denotes TRAF6
T2782 3893-3969 Positive_regulation denotes TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
T2715 3909-3925 Protein denotes IκB kinase (IKK)
T2703 3909-3969 Protein denotes IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
T2707 3930-3947 Entity denotes mitogen-activated
T2787 3930-3961 Positive_regulation denotes mitogen-activated protein (MAP)
T2753 3930-3961 Protein denotes mitogen-activated protein (MAP)
T2702 3957-3960 Protein denotes MAP
T2776 4003-4046 Positive_regulation denotes activation of specific transcription factor
T2729 4014-4046 Protein denotes of specific transcription factor
T2747 4071-4076 Protein denotes NF-κB
T2749 4081-4085 Protein denotes AP-1
T2771 4343-4369 Entity denotes of activator binding sites
T2734 4364-4369 Entity denotes sites
T2696 4542-4547 Protein denotes NF-κB
T2750 4679-4693 Entity denotes southeast Asia
T2783 4714-4757 Binding denotes NF-κB binding sites, respectively [1], [28]
T2742 4714-4757 Protein denotes NF-κB binding sites, respectively [1], [28]
T2770 4728-4733 Entity denotes sites
T2704 4852-4866 Entity denotes T cells (NFAT)
T2701 4875-4880 Protein denotes NFAT5
T2736 4896-4902 Protein denotes TonEBP
T2745 4911-4920 Entity denotes to a site
T2722 5039-5054 Entity denotes This NFAT5 site
T2757 5044-5049 Protein denotes NFAT5
T2760 5064-5104 Protein denotes the core NF-κB binding motifs in the LTR
T2779 5064-5105 Localization denotes the core NF-κB binding motifs in the LTR
T2725 5068-5072 Entity denotes core
T2735 5212-5228 Entity denotes primary monocyte
T2711 5237-5254 Entity denotes macrophages (MDM)
T2744 5250-5253 Protein denotes MDM
T2731 5272-5277 Protein denotes NFAT5
T2724 5338-5360 Protein denotes by the MAP kinase p38,
T2700 5338-5360 Protein denotes by the MAP kinase p38,
T2694 5338-5360 Protein denotes by the MAP kinase p38,
T2706 5345-5348 Protein denotes MAP
T2726 5384-5389 Protein denotes MyD88
T2775 5384-5406 Positive_regulation denotes MyD88 signaling, [32],
T2755 5426-5431 Protein denotes NFAT5
T2766 5456-5467 Protein denotes MTb-induced
T2732 5530-5539 Entity denotes monocytes
T2743 5544-5578 Entity denotes peripheral blood mononuclear cells
T2752 5601-5611 Protein denotes that NFAT5
T2717 5636-5640 Entity denotes site
T2740 5671-5692 Protein denotes efficient MTb-induced
T2733 5735-5738 Protein denotes MDM
T2763 5743-5747 Entity denotes PBMC
T2772 5759-5871 Positive_regulation denotes we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
T2721 5779-5782 Protein denotes MTb
T2780 5779-5792 Regulation denotes MTb infection
T2767 5803-5808 Protein denotes NFAT5
T2774 5803-5843 Gene_expression denotes NFAT5 gene expression in human monocytes
T2712 5828-5843 Entity denotes human monocytes
T2741 5849-5864 Protein denotes MyD88-dependent
T2773 5918-5937 Gene_expression denotes of NFAT5 expression
T2723 5921-5926 Protein denotes NFAT5
T2695 5945-5957 Protein denotes PRR-mediated
T2720 6003-6008 Protein denotes NFAT5
T2756 6036-6047 Protein denotes MTb-induced
T2885 6188-6229 Entity denotes peripheral blood mononuclear cells, PBMC)
T2884 6224-6228 Entity denotes PBMC
T2883 6264-6268 Protein denotes Bank
T3452 6317-6353 Entity denotes PBMC from normal unidentified donors
T3455 6498-6529 Entity denotes 2 mM L-glutamine (BioWhittaker,
T3442 6617-6653 Entity denotes Gemini Bio-Products, www.gembio.com)
T3456 6655-6670 Entity denotes Human monocytes
T3453 6685-6707 Entity denotes from PBMC preparations
T3441 6690-6694 Entity denotes PBMC
T3449 6735-6739 Protein denotes CD14
T3443 6756-6796 Protein denotes Miltenyi Biotec (www.miltenyibiotec.com)
T3450 6852-6863 Entity denotes 1×106 cells
T3447 6964-6992 Protein denotes ng/ml recombinant human MCSF
T3448 7059-7079 Entity denotes Nabi, Boca Raton, FL
T3446 7082-7099 Entity denotes The cell cultures
T3457 7158-7169 Entity denotes supernatant
T3445 7209-7213 Protein denotes MCSF
T3458 7247-7299 Entity denotes % of the adherent cells obtained with this technique
T3460 7249-7299 Binding denotes of the adherent cells obtained with this technique
T3451 7249-7299 Entity denotes of the adherent cells obtained with this technique
T3454 7305-7322 Entity denotes CD14+ macrophages
T3444 7498-7508 Entity denotes 293T cells
T3459 7498-7547 Binding denotes 293T cells were obtained from ATCC (www.atcc.org)
T3570 7677-7685 Protein denotes HIV-1Bal
T3571 7813-7826 Entity denotes AIDS Reagents
T3572 7915-7917 Entity denotes 25
T4046 8072-8083 Entity denotes nucleotides
T4047 8390-8423 Entity denotes Hind III restriction enzyme sites
T4050 8399-8417 Protein denotes restriction enzyme
T4051 8516-8550 Entity denotes NFAT5 binding site-mutant (N5-Mut)
T4052 8543-8549 Entity denotes N5-Mut
T4048 8543-8549 Protein denotes N5-Mut
T4049 8764-8791 Protein denotes Renilla luciferase (pRL-TK)
T4054 8784-8790 Protein denotes pRL-TK
T4053 8813-8843 Entity denotes Effectene transfection reagent
T4045 8870-8875 Entity denotes Cells
T4055 8950-8962 Protein denotes 10 µg/ml MTb
T4299 9170-9177 Protein denotes DNase I
T4298 9191-9208 Protein denotes Recombinant NFAT5
T4292 9210-9221 Entity denotes amino acids
T4293 9236-9249 Entity denotes an N-terminal
T4291 9278-9301 Entity denotes E. coli BL21(DE3) cells
T4300 9378-9401 Entity denotes Ni-NTA agarose (Qiagen)
T4297 9381-9384 Entity denotes NTA
T4295 9403-9418 Protein denotes Recombinant p50
T4301 9403-9441 Binding denotes Recombinant p50 and p65 were purchased
T4296 9423-9426 Protein denotes p65
T4294 9479-9555 Protein denotes Quantitative DNase I footprinting was performed as previously described [31]
T4619 9686-9706 Entity denotes the NIH AIDS Reagent
T4616 9821-9824 Protein denotes env
T4618 9826-9831 Protein denotes gp160
T4620 9826-9843 Entity denotes gp160 amino acids
T4621 9893-9898 Protein denotes CXCR4
T4624 9983-9987 Protein denotes CCR5
T4623 10031-10035 Protein denotes CCR5
T4617 10039-10059 Protein denotes a secondary receptor
T4615 10129-10142 Entity denotes DNA extracted
T4622 10148-10152 Entity denotes PBMC
T5025 10373-10379 Protein denotes of MDM
T5028 10385-10388 Protein denotes RNA
T5023 10466-10486 Protein denotes the NFAT5 transcript
T5022 10470-10475 Protein denotes NFAT5
T5030 10564-10590 Protein denotes non-specific siRNA effects
T5024 10623-10655 Protein denotes green fluorescent protein (GFP),
T5027 10650-10653 Protein denotes GFP
T5026 10686-10689 Protein denotes MDM
T5031 10761-10794 Entity denotes siPORT NeoFX transfection reagent
T5033 11018-11023 Entity denotes cells
T5032 11067-11070 Protein denotes MDM
T5029 11126-11131 Protein denotes NFAT5
T5034 11126-11142 Gene_expression denotes NFAT5 expression
T5592 11194-11229 Gene_expression denotes Stable THP-1 cells expressing shRNA
T5591 11194-11229 Transcription denotes Stable THP-1 cells expressing shRNA
T5581 11194-11229 Entity denotes Stable THP-1 cells expressing shRNA
T5569 11224-11229 Protein denotes shRNA
T5575 11271-11298 Protein denotes shRNA targeting human MyD88
T5573 11287-11298 Protein denotes human MyD88
T5585 11396-11401 Protein denotes shRNA
T5582 11396-11502 Protein denotes shRNA targeting human IRAK1 (forward primer 5′-CCGGAGCAGCTGTCCAGGTTTCGTCTCATAAAACCTGGACAGCTGCTCCTTTTTG-3′,
T5571 11511-11584 Protein denotes primer 5′-AATTCAAAAAGGAGCAGCTGTCCAGGTTTTATGAGACGAAACCTGGACAGCTGCT-3′ mRNA
T5568 11586-11591 Protein denotes IRAK1
T5590 11592-11596 Protein denotes mRNA
T5576 11632-11722 Protein denotes human TRAF6 (forward primer 5′-CCGGAGAAACCTGTTGTGATTCGTCTCATAAATCACAACAGGTTTCTCCTTTTTG-3′,
T5572 11801-11806 Protein denotes TRAF6
T5577 11807-11811 Protein denotes mRNA
T5589 11938-11943 Protein denotes shRNA
T5578 12023-12041 Protein denotes the shRNA-encoding
T5586 12102-12106 Protein denotes PAX2
T5570 12155-12175 Entity denotes transfection reagent
T5580 12202-12214 Entity denotes Supernatants
T5587 12341-12365 Entity denotes the lentiviral particles
T5583 12379-12388 Entity denotes the cells
T5588 12394-12421 Entity denotes supernatants from the virus
T5579 12432-12437 Entity denotes cells
T5584 12465-12474 Entity denotes polybrene
T5567 12575-12580 Entity denotes cells
T5574 12626-12645 Entity denotes 0.8 µg/ml puromycin
T5971 12648-12651 Protein denotes MTb
T5975 12664-12667 Protein denotes MTb
T5974 12785-12788 Protein denotes Dif
T5972 12785-12790 Entity denotes Difco
T5983 12825-12855 Entity denotes albumin dextrose complex (ADC)
T5982 12825-12855 Protein denotes albumin dextrose complex (ADC)
T5979 12825-12855 Entity denotes albumin dextrose complex (ADC)
T5978 12851-12854 Entity denotes ADC
T5980 12876-12881 Protein denotes Sigma
T5977 13156-13180 Entity denotes a single cell suspension
T5973 13252-13299 Entity denotes further dilution with RPMI 1640 medium for cell
T5976 13295-13299 Entity denotes cell
T5984 13572-13596 Regulation denotes infection of primary MDM
T5981 13582-13596 Protein denotes of primary MDM
T6494 13623-13631 Entity denotes extracts
T6512 13676-13704 Entity denotes 150 mM NaCl, 50 mM Tris–HCl,
T6513 13695-13703 Entity denotes Tris–HCl
T6506 13695-13703 Entity denotes Tris–HCl
T6497 13700-13703 Entity denotes HCl
T6504 13713-13722 Entity denotes 1% Triton
T6495 13724-13736 Entity denotes 10% glycerol
T6500 13754-13781 Protein denotes Complete EDTA-free Protease
T6509 13763-13772 Entity denotes EDTA-free
T6493 13782-13791 Entity denotes Inhibitor
T6516 13830-13838 Entity denotes Extracts
T6502 13897-13918 Entity denotes v/v 2-mercaptoethanol
T6505 13923-13931 Protein denotes proteins
T6510 13960-13967 Entity denotes The gel
T6511 13987-14041 Entity denotes a nitrocellulose Trans-Blot Transfer Membrane (BioRad)
T6492 13987-14041 Entity denotes a nitrocellulose Trans-Blot Transfer Membrane (BioRad)
T6490 14004-14009 Protein denotes Trans
T6501 14073-14076 Entity denotes 1 h
T6519 14088-14098 Entity denotes a solution
T6499 14102-14116 Protein denotes 4% BSA (Sigma)
T6496 14110-14115 Protein denotes Sigma
T6507 14167-14177 Entity denotes 50 mM Tris
T6503 14182-14193 Entity denotes 150 mM NaCl
T6491 14205-14208 Protein denotes BSA
T6515 14272-14309 Entity denotes of rabbit anti-NFAT5 antibody (H-300)
T6508 14311-14316 Protein denotes Santa
T6518 14358-14388 Protein denotes of goat anti-Lamin-B1 antibody
T6498 14399-14404 Protein denotes Santa
T6517 14441-14464 Entity denotes 2 h at room temperature
T6514 14533-14573 Protein denotes anti-goat-HRP (Santa Cruz Biotechnology)
T6520 14692-14747 Entity denotes SuperSignal West Pico Chemiluminescent Reagent (Pierce)
T6671 14750-14766 Protein denotes Quantitative PCR
T6674 14767-14793 Transcription denotes The mRNA expression levels
T6673 14767-14793 Gene_expression denotes The mRNA expression levels
T6672 14771-14775 Protein denotes mRNA
T6670 14810-14891 Protein denotes by SYBR Green-based real-time PCR (Applied Biosystems, www.appliedbiosystems.com)
T6669 15033-15045 Protein denotes β-actin mRNA
T6668 15033-15045 Protein denotes β-actin mRNA
T6753 15230-15296 Entity denotes the paired Student t-Test with the aid of Microsoft Excel software
T7248 15343-15346 Protein denotes MTb
T7251 15439-15457 Positive_regulation denotes of MTb stimulation
T7249 15442-15445 Protein denotes MTb
T7250 15638-15684 Binding denotes linked to the firefly luciferase reporter gene
T7242 15645-15684 Protein denotes to the firefly luciferase reporter gene
T7239 15652-15670 Protein denotes firefly luciferase
T7243 15821-15832 Protein denotes MTb (H37Rv)
T7240 15826-15829 Entity denotes H37
T7245 15847-15850 Protein denotes MTb
T7244 15892-15901 Entity denotes monocytes
T7247 15950-15953 Protein denotes MTb
T7246 16081-16091 Protein denotes luciferase
T7241 16397-16400 Protein denotes TNF
T22261 16471-16476 Protein denotes NFAT5
T22303 16471-16501 Binding denotes NFAT5 interaction with the LTR
T22302 16519-16530 Protein denotes MTb-induced
T22284 16556-16559 Protein denotes MTb
T22306 16556-16571 Positive_regulation denotes MTb stimulation
T22263 16703-16707 Entity denotes site
T22289 16781-16793 Protein denotes plasmid pGL3
T22286 16881-16903 Protein denotes the Renilla luciferase
T22256 16912-16939 Protein denotes plasmid pRL-TK (0.03 µg/ml)
T22254 16976-16981 Entity denotes Cells
T22293 17039-17042 Protein denotes MTb
T22270 17165-17180 Entity denotes untreated cells
T22280 17259-17274 Entity denotes untreated cells
T22255 17326-17329 Protein denotes MTb
T22298 17326-17351 Entity denotes MTb lysate-treated cells,
T22290 17432-17461 Entity denotes cells treated with MTb lysate
T22283 17451-17454 Protein denotes MTb
T22262 17587-17590 Protein denotes MTb
T22257 17709-17727 Entity denotes p<0.05; **, p<0.01
T22305 17771-17920 Negative_regulation denotes Specific disruption of the NFAT5 binding site significantly reduces LTR-reporter gene activity in monocytic cells in response to MTb lysate treatment
T22307 17791-17816 Binding denotes of the NFAT5 binding site
T22260 17791-17816 Entity denotes of the NFAT5 binding site
T22275 17798-17803 Protein denotes NFAT5
T22265 17852-17856 Protein denotes gene
T22281 17869-17884 Entity denotes monocytic cells
T22272 17900-17903 Protein denotes MTb
T22300 17956-17966 Protein denotes luciferase
T22296 17995-18006 Entity denotes nucleotides
T22309 18079-18120 Binding denotes the NFAT5 binding site mutations (N5-Mut)
T22279 18079-18120 Entity denotes the NFAT5 binding site mutations (N5-Mut)
T22276 18083-18088 Protein denotes NFAT5
T22292 18113-18119 Entity denotes N5-Mut
T22266 18113-18119 Protein denotes N5-Mut
T22291 18138-18147 Entity denotes the cells
T22285 18182-18194 Protein denotes 10 µg/ml MTb
T22308 18223-18250 Negative_regulation denotes Disruption of NFAT5 binding
T22273 18234-18242 Protein denotes of NFAT5
T22282 18375-18380 Entity denotes cells
T22259 18399-18402 Protein denotes MTb
T22301 18411-18413 Entity denotes p<
T22297 18456-18475 Entity denotes the untreated cells
T22304 18595-18632 Regulation denotes Renilla luciferase control expression
T22278 18603-18613 Protein denotes luciferase
T22288 18658-18668 Entity denotes Nucleotide
T22267 18710-18715 Protein denotes NFAT5
T22258 18794-18797 Protein denotes MTb
T22295 18815-18820 Protein denotes NFAT5
T22268 18815-18854 Protein denotes NFAT5 protein levels in monocytic cells
T22277 18839-18854 Entity denotes monocytic cells
T22294 18921-18924 Protein denotes MTb
T22264 18959-18978 Entity denotes Whole cell extracts
T22299 19028-19047 Entity denotes anti-NFAT5 antibody
T22271 19052-19086 Protein denotes antibody directed against Lamin-B1
T22274 19078-19086 Protein denotes Lamin-B1
T22287 19168-19173 Protein denotes NFAT5
T22269 19314-19317 Protein denotes MTb
T8074 19327-19442 Negative_regulation denotes Specific disruption of NFAT5 binding impairs LTR-driven transcription in THP-1 cells in response to MTb stimulation
T8049 19350-19355 Protein denotes NFAT5
T8070 19427-19430 Protein denotes MTb
T8077 19427-19442 Positive_regulation denotes MTb stimulation
T8066 19452-19482 Protein denotes the transcription factor NFAT5
T8057 19456-19476 Protein denotes transcription factor
T8041 19494-19498 Entity denotes core
T8067 19571-19588 Entity denotes two thymines (TT)
T8054 19604-19618 Entity denotes cytosines (CC)
T8061 19615-19617 Entity denotes CC
T8060 19622-19640 Protein denotes the proximal NF-κB
T8068 19662-19668 Protein denotes N5-Mut
T8047 19662-19668 Entity denotes N5-Mut
T8076 19693-19713 Binding denotes the binding of NFAT5
T8065 19705-19713 Protein denotes of NFAT5
T8075 19745-19778 Binding denotes binding of NF-κB unperturbed [31]
T8050 19753-19773 Protein denotes of NF-κB unperturbed
T8046 19811-19824 Protein denotes NFAT5 for MTb
T8062 19821-19824 Protein denotes MTb
T8042 19878-19883 Protein denotes NFAT5
T8052 19964-19967 Protein denotes MTb
T8048 20017-20020 Protein denotes MTb
T8080 20053-20085 Binding denotes of the NFAT5 binding site-mutant
T8064 20053-20085 Entity denotes of the NFAT5 binding site-mutant
T8072 20117-20119 Entity denotes p<
T8078 20166-20188 Binding denotes the NFAT5 binding site
T8051 20166-20188 Entity denotes the NFAT5 binding site
T8058 20170-20175 Protein denotes NFAT5
T8043 20216-20258 Entity denotes THP-1 cells stimulated with the MTb lysate
T8040 20248-20251 Protein denotes MTb
T8056 20351-20354 Protein denotes MTb
T8081 20351-20408 Positive_regulation denotes MTb lysate stimulation directly enhances NFAT5 expression
T8069 20392-20397 Protein denotes NFAT5
T8079 20392-20408 Gene_expression denotes NFAT5 expression
T8053 20439-20444 Entity denotes cells
T8045 20502-20507 Protein denotes NFAT5
T8063 20502-20522 Protein denotes NFAT5 protein levels
T8059 20577-20582 Protein denotes NFAT5
T8073 20577-20597 Protein denotes NFAT5 protein levels
T8039 20632-20635 Protein denotes MTb
T8044 20689-20692 Protein denotes MTb
T8071 20723-20728 Protein denotes NFAT5
T8055 20768-20770 Entity denotes MT
T8725 20810-20813 Protein denotes MTb
T8726 20824-20841 Protein denotes NFAT5 mRNA levels
T8737 20830-20834 Protein denotes mRNA
T8724 20845-20854 Protein denotes human MDM
T8722 20866-20925 Entity denotes macrophages, which are the primary target of MTb infection,
T8713 20911-20914 Entity denotes MTb
T8734 21021-21024 Protein denotes MTb
T8739 21033-21095 Positive_regulation denotes to directly enhance NFAT5 mRNA expression in primary human MDM
T8733 21053-21058 Protein denotes NFAT5
T8714 21053-21063 Protein denotes NFAT5 mRNA
T8743 21053-21074 Gene_expression denotes NFAT5 mRNA expression
T8729 21078-21095 Protein denotes primary human MDM
T8735 21109-21112 Protein denotes MDM
T8711 21149-21158 Entity denotes the cells
T8720 21168-21171 Protein denotes MTb
T8717 21219-21224 Protein denotes NFAT5
T8738 21219-21296 Gene_expression denotes NFAT5 gene expression levels by quantitative real-time PCR at 24 and 48 hours
T8730 21366-21386 Protein denotes NFAT5 mRNA synthesis
T8740 21390-21443 Regulation denotes infecting MDM with live or heat-inactivated R5-tropic
T8715 21400-21403 Protein denotes MDM
T8732 21409-21443 Entity denotes live or heat-inactivated R5-tropic
T8736 21562-21565 Protein denotes MTb
T8718 21597-21614 Protein denotes NFAT5 mRNA levels
T8727 21603-21607 Protein denotes mRNA
T8719 21622-21623 Entity denotes p
T8731 21638-21639 Entity denotes p
T8721 21735-21740 Protein denotes NFAT5
T8728 21735-21764 Protein denotes NFAT5 mRNA levels (Figure 2A)
T8742 21766-21832 Positive_regulation denotes Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM
T8712 21772-21775 Protein denotes MTb
T8716 21798-21803 Protein denotes NFAT5
T8723 21798-21808 Protein denotes NFAT5 mRNA
T8741 21798-21819 Gene_expression denotes NFAT5 mRNA expression
T8710 21823-21832 Protein denotes human MDM
T23562 21970-21973 Protein denotes MTb
T16832 21970-21973 Protein denotes MTb
T23548 21982-21987 Protein denotes NFAT5
T16848 21982-21987 Protein denotes NFAT5
T23572 21982-22003 Gene_expression denotes NFAT5 gene expression
T16896 21982-22003 Gene_expression denotes NFAT5 gene expression
T23544 22018-22026 Protein denotes of NFAT5
T23552 22060-22063 Protein denotes MTb
T23575 22060-22076 Regulation denotes MTb co-infection
T23545 22082-22099 Protein denotes MTb but not HIV-1
T23540 22110-22130 Protein denotes NFAT5 mRNA synthesis
T23533 22134-22151 Entity denotes human macrophages
T23527 22153-22156 Protein denotes MDM
T23571 22171-22213 Binding denotes from PBMC obtained from four normal donors
T23529 22171-22213 Entity denotes from PBMC obtained from four normal donors
T23555 22215-22224 Entity denotes The cells
T23532 22264-22298 Entity denotes heat-inactivated or live R5-tropic
T23514 22339-22342 Protein denotes MTb
T23556 22419-22422 Protein denotes PCR
T23531 22432-22440 Protein denotes of NFAT5
T23522 22441-22445 Protein denotes mRNA
T23524 22519-22524 Protein denotes NFAT5
T23538 22519-22529 Protein denotes NFAT5 mRNA
T23516 22553-22558 Entity denotes cells
T23560 22724-22727 Protein denotes MTb
T23539 22733-22747 Protein denotes NFAT5-specific
T23573 22754-22853 Negative_regulation denotes effectively suppresses NFAT5 expression in MDM in both the absence and presence of MTb co-infection
T23546 22777-22782 Protein denotes NFAT5
T23569 22777-22800 Gene_expression denotes NFAT5 expression in MDM
T23564 22797-22800 Protein denotes MDM
T23574 22834-22853 Regulation denotes of MTb co-infection
T23554 22837-22840 Protein denotes MTb
T23563 22855-22858 Protein denotes MDM
T23547 22944-22956 Protein denotes RNA specific
T23549 22961-22966 Protein denotes NFAT5
T23551 22985-22988 Protein denotes GFP
T23550 23018-23021 Protein denotes MTb
T23541 23063-23072 Entity denotes the cells
T23515 23105-23108 Protein denotes MTb
T23570 23105-23118 Regulation denotes MTb infection
T23568 23105-23187 Positive_regulation denotes MTb infection significantly increased NFAT5 expression in comparison to uninfected
T23557 23143-23148 Protein denotes NFAT5
T23565 23143-23159 Gene_expression denotes NFAT5 expression
T23528 23188-23205 Entity denotes cells (open bars)
T23543 23212-23215 Protein denotes MDM
T23521 23233-23252 Protein denotes with NFAT5-specific
T23561 23306-23340 Protein denotes MTb-induced (p = 0.021) NFAT5 mRNA
T23558 23306-23340 Protein denotes MTb-induced (p = 0.021) NFAT5 mRNA
T23542 23463-23466 Protein denotes MTb
T23567 23463-23514 Regulation denotes MTb co-infection when NFAT5 expression is abrogated
T23566 23480-23514 Negative_regulation denotes when NFAT5 expression is abrogated
T23536 23485-23490 Protein denotes NFAT5
T23576 23485-23501 Gene_expression denotes NFAT5 expression
T23526 23524-23527 Protein denotes MDM
T23534 23529-23556 Protein denotes MDM from four normal donors
T23518 23579-23593 Protein denotes NFAT5-specific
T23520 23633-23638 Entity denotes Cells
T23525 23710-23713 Protein denotes MTb
T23523 23849-23889 Entity denotes cells transfected with NFAT5-specific si
T23530 23872-23886 Protein denotes NFAT5-specific
T23519 23872-23889 Entity denotes NFAT5-specific si
T23537 23889-23892 Protein denotes RNA
T23559 23910-23940 Entity denotes cells transfected with control
T23535 23951-23952 Entity denotes p
T23553 23988-23996 Entity denotes of cells
T23517 24046-24076 Entity denotes noticeable macrophage necrosis
T10220 24146-24151 Protein denotes NFAT5
T10196 24229-24248 Entity denotes the reporter assays
T10242 24351-24356 Protein denotes NFAT5
T10251 24357-24361 Protein denotes mRNA
T10254 24372-24404 Regulation denotes MDM co-infected with a subtype B
T10198 24372-24404 Protein denotes MDM co-infected with a subtype B
T10222 24467-24470 Protein denotes MTb
T10235 24547-24609 Protein denotes the CCR5-tropic envelope region of HIV-1Bal (HIV-1Lai/Bal-env)
T10226 24646-24657 Protein denotes primary MDM
T10237 24725-24730 Protein denotes NF-κB
T10211 24735-24740 Protein denotes NFAT5
T10214 24744-24755 Protein denotes MTb-induced
T10243 24948-24966 Protein denotes Bal-Env infectious
T10208 24948-24966 Protein denotes Bal-Env infectious
T10213 25079-25103 Protein denotes of the HIV-1Bal envelope
T10249 25104-25115 Protein denotes co-receptor
T10212 25143-25184 Protein denotes the HIV-1Lai envelope co-receptor binding
T10215 25165-25176 Protein denotes co-receptor
T10252 25249-25253 Entity denotes PBMC
T10238 25306-25335 Protein denotes proper co-receptor engagement
T10221 25421-25426 Protein denotes NFAT5
T10206 25421-25522 Protein denotes NFAT5 mRNA levels in MDM using an siRNA that suppresses both NFAT5 mRNA and NFAT5 protein levels [31]
T10231 25442-25445 Protein denotes MDM
T10232 25482-25487 Protein denotes NFAT5
T10223 25482-25492 Protein denotes NFAT5 mRNA
T10234 25497-25502 Protein denotes NFAT5
T10241 25497-25522 Protein denotes NFAT5 protein levels [31]
T10239 25585-25590 Protein denotes NFAT5
T10248 25599-25604 Protein denotes NFAT5
T10250 25625-25628 Protein denotes MTb
T10194 25641-25645 Entity denotes p = 
T10233 25656-25659 Protein denotes MTb
T10205 25670-25674 Entity denotes p = 
T10245 25681-25684 Protein denotes MDM
T10210 25724-25727 Protein denotes GFP
T10192 25739-25742 Protein denotes MTb
T10218 25767-25782 Protein denotes MDM (Figure 2B)
T10217 25888-25928 Protein denotes human MDM, which are non-dividing cells,
T10229 25909-25927 Entity denotes non-dividing cells
T10247 26032-26035 Protein denotes MDM
T10246 26045-26050 Protein denotes NFAT5
T10201 26086-26091 Protein denotes NFAT5
T10202 26111-26142 Entity denotes transfected with control GFP si
T10199 26136-26139 Protein denotes GFP
T10230 26142-26145 Protein denotes RNA
T10244 26236-26245 Entity denotes the cells
T10236 26277-26280 Protein denotes MTb
T10228 26354-26420 Entity denotes supernatants from MDM transfected with NFAT5-specific siRNA or GFP
T10197 26372-26375 Protein denotes MDM
T10224 26393-26407 Protein denotes NFAT5-specific
T10203 26417-26420 Protein denotes GFP
T10204 26431-26454 Protein denotes RNA at days 6, 9 and 12
T10255 26498-26517 Negative_regulation denotes of NFAT5 inhibition
T10195 26501-26506 Protein denotes NFAT5
T10193 26521-26532 Protein denotes MTb-induced
T10200 26640-26669 Entity denotes the NFAT5 siRNA-treated cells
T10209 26644-26649 Protein denotes NFAT5
T10216 26682-26714 Entity denotes to cells treated with control si
T10219 26704-26714 Entity denotes control si
T10240 26714-26717 Protein denotes RNA
T10207 26821-26826 Protein denotes NFAT5
T10253 26821-26837 Gene_expression denotes NFAT5 expression
T10227 26891-26894 Protein denotes MDM
T10225 26912-26915 Protein denotes MTb
T12064 26918-26923 Protein denotes NF-κB
T12042 26928-26933 Protein denotes NFAT5
T12114 26928-26958 Binding denotes NFAT5 binding to the HIV-1 LTR
T12054 27020-27028 Protein denotes of NFAT5
T12073 27042-27053 Protein denotes MTb-induced
T12127 27099-27133 Regulation denotes modulation of recruitment of NFAT5
T12126 27110-27133 Binding denotes of recruitment of NFAT5
T12044 27125-27133 Protein denotes of NFAT5
T12089 27177-27192 Protein denotes NFAT5-regulated
T12118 27216-27237 Negative_regulation denotes disrupt NFAT5 binding
T12076 27224-27229 Protein denotes NFAT5
T12120 27224-27237 Binding denotes NFAT5 binding
T12077 27279-27282 Protein denotes MTb
T12065 27375-27383 Protein denotes of NFAT5
T12101 27422-27425 Protein denotes MTb
T12047 27573-27587 Entity denotes the NFAT5 site
T12085 27577-27582 Protein denotes NFAT5
T12097 27618-27645 Entity denotes the two NF-κB binding sites
T12119 27750-27772 Binding denotes the NFAT5 binding site
T12061 27750-27772 Entity denotes the NFAT5 binding site
T12062 27754-27759 Protein denotes NFAT5
T12079 27829-27848 Entity denotes the CC dinucleotide
T12072 27829-27848 Entity denotes the CC dinucleotide
T12075 27858-27885 Entity denotes the core NFAT5 binding site
T12055 27862-27866 Entity denotes core
T12109 27867-27872 Protein denotes NFAT5
T12103 27933-27944 Protein denotes NF-κB/NFAT5
T12050 27933-27944 Protein denotes NF-κB/NFAT5
T12074 27939-27944 Protein denotes NFAT5
T12093 28027-28032 Protein denotes NFAT5
T12084 28067-28084 Entity denotes two guanines (GG)
T12082 28095-28101 Entity denotes I site
T12087 28122-28129 Entity denotes thymine
T12048 28134-28141 Entity denotes adenine
T12069 28143-28145 Protein denotes TA
T12071 28170-28173 Protein denotes mut
T12099 28210-28212 Protein denotes TA
T12108 28223-28257 Entity denotes the second, more distal NF-κB site
T12068 28247-28252 Protein denotes NF-κB
T12102 28262-28264 Entity denotes II
T12059 28307-28313 Protein denotes II-Mut
T12058 28332-28395 Entity denotes a double NF-κB site mutant virus (HIV-1Lai/Bal-env-κB I+II-Mut)
T12051 28341-28346 Protein denotes NF-κB
T12113 28467-28498 Regulation denotes the HIV-1 LTR on MTb regulation
T12043 28484-28487 Protein denotes MTb
T25197 28544-28625 Negative_regulation denotes Specific disruption of NFAT5 or NF-κB binding sites in the LTR of HIV-1 subtype B
T25143 28567-28572 Protein denotes NFAT5
T25171 28576-28625 Entity denotes NF-κB binding sites in the LTR of HIV-1 subtype B
T25172 28704-28709 Protein denotes NF-κB
T25159 28714-28719 Protein denotes NFAT5
T25194 28714-28742 Binding denotes NFAT5 binding site mutations
T25148 28714-28742 Entity denotes NFAT5 binding site mutations
T25142 28839-28897 Entity denotes The NF-κB binding site mutants (HIV-1Lai/Bal-env-κB I-Mut,
T25145 28893-28896 Protein denotes Mut
T25154 28921-28924 Protein denotes Mut
T25196 28961-29012 Binding denotes NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
T25175 28961-29012 Entity denotes NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
T25190 29178-29198 Binding denotes of the NFAT5 binding
T25170 29185-29190 Protein denotes NFAT5
T25161 29199-29203 Entity denotes site
T25177 29214-29219 Protein denotes NFAT5
T25198 29214-29227 Binding denotes NFAT5 binding
T25167 29265-29270 Protein denotes NF-κB
T25195 29265-29324 Binding denotes NF-κB p50/p65 binding to the overlapping NF-κB binding site
T25180 29265-29324 Protein denotes NF-κB p50/p65 binding to the overlapping NF-κB binding site
T25187 29287-29324 Entity denotes to the overlapping NF-κB binding site
T25181 29339-29345 Protein denotes DNaseI
T25144 29543-29573 Protein denotes of recombinant NF-κB (p50/p65)
T25156 29565-29572 Protein denotes p50/p65
T25153 29565-29572 Protein denotes p50/p65
T25160 29569-29572 Protein denotes p65
T25185 29606-29611 Protein denotes NFAT5
T25179 29676-29683 Protein denotes DNase I
T25182 29711-29716 Protein denotes NF-κB
T25176 29721-29726 Protein denotes NFAT5
T25193 29801-29820 Binding denotes NF-κB binding sites
T25157 29801-29820 Protein denotes NF-κB binding sites
T25192 29801-29870 Negative_regulation denotes NF-κB binding sites effectively abrogates recombinant p50/p65 binding
T25186 29815-29820 Entity denotes sites
T25188 29843-29870 Binding denotes recombinant p50/p65 binding
T25166 29855-29862 Protein denotes p50/p65
T25162 29855-29862 Protein denotes p50/p65
T25173 29859-29862 Protein denotes p65
T25146 29885-29891 Protein denotes DNaseI
T25183 29926-29937 Entity denotes nucleotides
T25163 30022-30029 Protein denotes II-Mut,
T25164 30093-30123 Protein denotes of recombinant NF-κB (p50/p65)
T25158 30115-30122 Protein denotes p50/p65
T25149 30115-30122 Protein denotes p50/p65
T25174 30119-30122 Protein denotes p65
T25147 30189-30196 Protein denotes DNase I
T25155 30224-30241 Protein denotes recombinant NF-κB
T25150 30293-30334 Entity denotes of the HIV-1 subtype B NF-κB binding site
T25191 30356-30393 Positive_regulation denotes enhances NFAT5 binding to this region
T25165 30365-30370 Protein denotes NFAT5
T25189 30365-30378 Binding denotes NFAT5 binding
T25152 30408-30414 Protein denotes DNaseI
T25184 30449-30460 Entity denotes nucleotides
T25168 30545-30552 Protein denotes II-Mut,
T25169 30616-30636 Protein denotes of recombinant NFAT5
T25151 30701-30708 Protein denotes DNase I
T25178 30736-30753 Protein denotes recombinant NFAT5
T12124 30838-30881 Binding denotes NFAT5 and NF-κB p50/p65 binding to the LTR,
T12107 30854-30861 Protein denotes p50/p65
T12046 30854-30861 Protein denotes p50/p65
T12088 30858-30861 Protein denotes p65
T12100 30897-30917 Protein denotes quantitative DNase I
T12095 31025-31071 Protein denotes of recombinant NFAT5 or NF-κB p50/p65 proteins
T12060 31025-31071 Protein denotes of recombinant NFAT5 or NF-κB p50/p65 proteins
T12063 31040-31045 Protein denotes NFAT5
T12105 31049-31054 Protein denotes NF-κB
T12112 31076-31131 Binding denotes shown in Figure 3B, the N5-Mut LTR could not bind NFAT5 true
T12092 31100-31106 Entity denotes N5-Mut
T12053 31100-31106 Entity denotes N5-Mut
T12104 31103-31106 Protein denotes Mut
T12090 31126-31131 Protein denotes NFAT5
T12086 31175-31182 Protein denotes p50/p65
T12045 31175-31182 Protein denotes p50/p65
T12125 31175-31190 Binding denotes p50/p65 binding
T12121 31175-31207 Negative_regulation denotes p50/p65 binding was not impaired true
T12081 31179-31182 Protein denotes p65
T12078 31267-31286 Entity denotes the GG dinucleotide
T12106 31290-31292 Protein denotes TA
T12094 31348-31355 Protein denotes p50/p65
T12066 31348-31355 Protein denotes p50/p65
T12116 31348-31363 Binding denotes p50/p65 binding
T12111 31352-31355 Protein denotes p65
T12056 31367-31376 Entity denotes each site
T12091 31465-31498 Protein denotes of both NF-κB sites (κB I+II-Mut)
T12067 31465-31498 Entity denotes of both NF-κB sites (κB I+II-Mut)
T12070 31486-31497 Protein denotes κB I+II-Mut
T12122 31508-31551 Negative_regulation denotes in abrogation of p50/p65 binding to the LTR
T12117 31522-31551 Binding denotes of p50/p65 binding to the LTR
T12110 31525-31532 Protein denotes p50/p65
T12057 31525-31532 Protein denotes p50/p65
T12049 31529-31532 Protein denotes p65
T12052 31562-31601 Protein denotes recombinant NFAT5 binding to the single
T12083 31606-31622 Protein denotes the double NF-κB
T12123 31729-31825 Negative_regulation denotes Thus, binding of NFAT5 or NF-κB p50/p65 to their respective motifs can be specifically disrupted true
T12115 31735-31795 Binding denotes binding of NFAT5 or NF-κB p50/p65 to their respective motifs
T12096 31761-31768 Protein denotes p50/p65
T12080 31761-31768 Protein denotes p50/p65
T12098 31765-31768 Protein denotes p65
T13614 31873-31878 Protein denotes NF-κB
T13626 31883-31888 Protein denotes NFAT5
T13606 31934-31946 Protein denotes MTb-mediated
T13573 32044-32049 Protein denotes NF-κB
T13635 32053-32058 Protein denotes NFAT5
T13633 32120-32148 Entity denotes PBMC from four normal donors
T13609 32240-32245 Entity denotes cells
T13598 32268-32281 Protein denotes MTb (CDC1551)
T13617 32348-32351 Protein denotes p24
T13610 32370-32403 Entity denotes supernatants at days 4, 7, and 12
T13577 32517-32532 Protein denotes MTb-co-infected
T13588 32533-32581 Entity denotes cells at all timepoints examined (Figures 4A–4B)
T13657 32915-32934 Regulation denotes of MTb co-infection
T13612 32918-32921 Protein denotes MTb
T13581 32936-32939 Protein denotes p24
T13575 32980-32988 Entity denotes the PBMC
T13631 33035-33038 Protein denotes Mut
T13648 33238-33257 Regulation denotes by MTb co-infection
T13578 33241-33244 Protein denotes MTb
T13652 33362-33472 Regulation denotes of MTb co-infection, consistent with important roles for both NF-κB and NFAT5 in MTb-induced HIV-1 replication
T13616 33365-33368 Protein denotes MTb
T13596 33424-33429 Protein denotes NF-κB
T13625 33434-33439 Protein denotes NFAT5
T13624 33443-33454 Protein denotes MTb-induced
T25793 33518-33529 Protein denotes MTb-induced
T25803 33551-33555 Entity denotes PBMC
T25811 33564-33593 Binding denotes on binding of NFAT5 and NF-κB
T25804 33578-33583 Protein denotes NFAT5
T25795 33588-33593 Protein denotes NF-κB
T25812 33626-33661 Binding denotes of the NF-κB or NFAT5 binding sites
T25799 33626-33661 Entity denotes of the NF-κB or NFAT5 binding sites
T25806 33633-33638 Protein denotes NF-κB
T25791 33642-33647 Protein denotes NFAT5
T25808 33729-33739 Entity denotes human PBMC
T25798 33764-33767 Protein denotes MTb
T25794 33769-33797 Entity denotes PBMC from four normal donors
T25801 33914-33917 Protein denotes Mut
T25809 34032-34035 Protein denotes MTb
T25810 34080-34083 Protein denotes p24
T25807 34094-34114 Entity denotes culture supernatants
T25792 34191-34194 Protein denotes p24
T25796 34215-34245 Protein denotes the MTb uninfected (grey bars)
T25813 34250-34278 Regulation denotes MTb co-infected (black bars)
T25797 34250-34278 Protein denotes MTb co-infected (black bars)
T25800 34279-34283 Entity denotes PBMC
T25802 34429-34432 Protein denotes MTb
T25814 34429-34446 Regulation denotes MTb co-infection,
T25805 34465-34467 Entity denotes p<
T13636 34567-34575 Protein denotes of NF-κB
T13615 34580-34585 Protein denotes NFAT5
T13613 34594-34598 Entity denotes site
T13585 34608-34612 Protein denotes MDM,
T13605 34680-34683 Protein denotes MDM
T13597 34721-34732 Entity denotes these cells
T13621 34834-34837 Protein denotes Mut
T13619 34862-34865 Protein denotes Mut
T13643 34989-35002 Protein denotes MTb (CDC1551)
T13618 35038-35050 Entity denotes Supernatants
T13655 35190-35209 Regulation denotes of MTb co-infection
T13584 35193-35196 Protein denotes MTb
T13634 35284-35285 Entity denotes p
T13637 35321-35322 Entity denotes p
T13576 35364-35365 Entity denotes p
T13604 35408-35409 Entity denotes p
T26266 35552-35575 Entity denotes of NF-κB or NFAT5 sites
T26270 35555-35560 Protein denotes NF-κB
T26271 35564-35569 Protein denotes NFAT5
T26267 35596-35607 Protein denotes MTb-induced
T26276 35629-35632 Protein denotes MDM
T26263 35634-35637 Protein denotes MDM
T26275 35753-35756 Protein denotes Mut
T26269 35758-35784 Protein denotes HIV-1Lai/Bal-env-κB II-Mut
T26273 35919-35922 Protein denotes MTb
T26268 35956-35959 Protein denotes p24
T26265 35970-35994 Entity denotes the culture supernatants
T26264 36067-36070 Protein denotes p24
T26274 36154-36157 Protein denotes MTb
T26272 36187-36189 Entity denotes p<
T13641 36284-36288 Protein denotes MTb,
T13608 36289-36292 Protein denotes p24
T13574 36315-36324 Entity denotes the cells
T13611 36396-36399 Protein denotes B-I
T13590 36435-36438 Protein denotes p24
T13620 36478-36492 Entity denotes cells infected
T13603 36515-36522 Protein denotes -N5-Mut
T13586 36515-36522 Protein denotes -N5-Mut
T13602 36519-36522 Protein denotes Mut
T13630 36524-36525 Entity denotes p
T13639 36555-36558 Protein denotes p24
T13629 36712-36753 Entity denotes of cells with wild-type virus (Figure 5D)
T13580 36845-36849 Entity denotes site
T13628 36873-36884 Protein denotes NFAT5/NF-κB
T13627 36873-36884 Protein denotes NFAT5/NF-κB
T13599 36879-36884 Protein denotes NF-κB
T13642 36916-36919 Protein denotes Mut
T13622 37010-37013 Protein denotes p24
T13640 37076-37079 Protein denotes MTb
T13601 37186-37189 Protein denotes MTb
T13638 37217-37227 Entity denotes macrophage
T13649 37303-37326 Positive_regulation denotes the enhanced expression
T13583 37380-37385 Protein denotes NF-κB
T13658 37380-37458 Positive_regulation denotes NF-κB is efficiently activated in primary MDM in response to TLR agonists [51]
T13607 37414-37425 Protein denotes primary MDM
T13595 37441-37458 Entity denotes TLR agonists [51]
T13600 37493-37498 Protein denotes NFAT5
T13653 37493-37514 Gene_expression denotes NFAT5 gene expression
T13593 37531-37546 Entity denotes by TLR agonists
T13592 37548-37551 Protein denotes MDM
T13572 37609-37617 Protein denotes of NF-κB
T13587 37625-37630 Protein denotes NFAT5
T13654 37625-37674 Binding denotes NFAT5 binding site mutations on virus replication
T13645 37625-37674 Entity denotes NFAT5 binding site mutations on virus replication
T13589 37687-37690 Protein denotes MDM
T13651 37718-37737 Regulation denotes of MTb co-infection
T13646 37721-37724 Protein denotes MTb
T13579 37772-37776 Entity denotes PBMC
T13623 37781-37784 Protein denotes MDM
T13656 37781-37797 Regulation denotes MDM co-infection
T13650 37827-37859 Binding denotes the conserved NFAT5 binding site
T13647 37827-37859 Binding denotes the conserved NFAT5 binding site
T13632 37827-37859 Entity denotes the conserved NFAT5 binding site
T13594 37841-37846 Protein denotes NFAT5
T13582 37920-37926 Protein denotes by MTb
T13644 37933-37948 Entity denotes the NF-κB sites
T13591 37937-37942 Protein denotes NF-κB
T14456 37951-37956 Protein denotes NFAT5
T14459 38032-38035 Protein denotes MTb
T14477 38032-38045 Regulation denotes MTb infection
T14450 38135-38154 Entity denotes the reporter assays
T14457 38186-38214 Entity denotes three functional NF-κB sites
T14467 38203-38208 Protein denotes NF-κB
T14445 38324-38327 Protein denotes MTb
T14475 38324-38340 Regulation denotes MTb co-infection
T14449 38430-38438 Protein denotes of NFAT5
T14468 38442-38445 Protein denotes MTb
T14481 38602-38670 Binding denotes two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
T14472 38602-38670 Entity denotes two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
T14462 38606-38611 Protein denotes NFAT5
T14466 38641-38658 Entity denotes three NF-κB sites
T14471 38647-38652 Protein denotes NF-κB
T14479 38685-38712 Binding denotes the two NFAT5 binding sites
T14461 38685-38712 Entity denotes the two NFAT5 binding sites
T14460 38693-38698 Protein denotes NFAT5
T14463 38735-38750 Entity denotes each site to CC
T14452 38748-38750 Entity denotes CC
T14447 38815-38819 Entity denotes PBMC
T14465 38976-39015 Protein denotes MTb CDC1551 or left infected with virus
T14451 39155-39191 Protein denotes of HIV-198IN22 NFAT5-Mut (Figure 6B)
T14446 39155-39191 Protein denotes of HIV-198IN22 NFAT5-Mut (Figure 6B)
T14454 39217-39223 Protein denotes of MTb
T14464 39324-39370 Protein denotes HIV-198IN22 NFAT5-Mut replication (Figure 6C),
T14473 39342-39345 Protein denotes Mut
T14476 39399-39421 Binding denotes of NFAT5 binding sites
T14469 39399-39421 Entity denotes of NFAT5 binding sites
T14448 39402-39407 Protein denotes NFAT5
T14470 39491-39494 Protein denotes MTb
T14474 39491-39507 Regulation denotes MTb co-infection
T14455 39531-39561 Entity denotes functional NF-κB binding sites
T14480 39643-39681 Negative_regulation denotes disruption of NFAT5 binding to the LTR
T14478 39654-39681 Binding denotes of NFAT5 binding to the LTR
T14453 39657-39662 Protein denotes NFAT5
T14458 39723-39726 Protein denotes MTb
T14482 39723-39739 Regulation denotes MTb co-infection
T26792 39796-39813 Entity denotes of the NFAT5 site
T26799 39803-39808 Protein denotes NFAT5
T26796 39855-39866 Protein denotes MTb-induced
T26801 39899-39924 Binding denotes of the NFAT5 binding site
T26794 39899-39924 Entity denotes of the NFAT5 binding site
T26787 39906-39911 Protein denotes NFAT5
T26789 39975-39980 Protein denotes NFAT5
T26802 39975-40003 Binding denotes NFAT5 binding site mutations
T26797 39975-40003 Entity denotes NFAT5 binding site mutations
T26800 40062-40112 Binding denotes The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
T26791 40062-40112 Protein denotes The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
T26784 40080-40084 Entity denotes site
T26782 40093-40111 Entity denotes HIV-198IN22 N5-Mut
T26778 40093-40111 Protein denotes HIV-198IN22 N5-Mut
T26793 40216-40255 Entity denotes three NF-κB and two NFAT5 binding sites
T26779 40222-40227 Protein denotes NF-κB
T26781 40236-40241 Protein denotes NFAT5
T26795 40257-40288 Entity denotes The unique 3′ terminal adenine,
T26777 40308-40317 Protein denotes for NFAT5
T26780 40326-40338 Entity denotes to its site,
T26798 40442-40470 Entity denotes PBMC from four normal donors
T26783 40543-40548 Entity denotes Cells
T26790 40618-40621 Protein denotes MTb
T26788 40734-40764 Protein denotes viral p24 levels were measured
T26786 40887-40889 Entity denotes p<
T26785 40914-40917 Protein denotes MTb
T26803 40914-40930 Regulation denotes MTb co-infection
T16876 40975-40990 Protein denotes MyD88-dependent
T16873 41030-41111 Protein denotes the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication
T16874 41082-41093 Protein denotes MTb-induced
T16847 41173-41182 Entity denotes molecules
T16819 41224-41227 Protein denotes MTb
T16903 41224-41264 Positive_regulation denotes MTb stimulation of NFAT5 gene expression
T16904 41240-41264 Gene_expression denotes of NFAT5 gene expression
T16860 41243-41248 Protein denotes NFAT5
T16858 41307-41311 Protein denotes TLR2
T16889 41334-41339 Protein denotes NFAT5
T16879 41334-41351 Protein denotes NFAT5 mRNA levels
T16811 41388-41405 Protein denotes the TLR2-specific
T16859 41406-41413 Entity denotes agonist
T16883 41436-41441 Protein denotes NFAT5
T16831 41486-41489 Protein denotes Pam
T16900 41523-41549 Positive_regulation denotes to mock-stimulated control
T16795 41550-41567 Entity denotes cells (Figure 7A)
T16882 41675-41678 Protein denotes MTb
T16912 41675-41688 Regulation denotes MTb infection
T16843 41698-41715 Protein denotes NFAT5 mRNA levels
T16838 41704-41708 Protein denotes mRNA
T16914 41773-41838 Positive_regulation denotes that additional PRRs may be triggered during actual MTb infection true
T16835 41778-41793 Protein denotes additional PRRs
T16902 41818-41838 Regulation denotes actual MTb infection
T16816 41825-41828 Protein denotes MTb
T16915 41874-41910 Gene_expression denotes on NFAT5 gene expression (Figure 7A)
T16825 41877-41882 Protein denotes NFAT5
T28310 41960-41974 Protein denotes MyD88-mediated
T28293 42010-42013 Protein denotes MTb
T28329 42024-42043 Gene_expression denotes of NFAT5 expression
T28286 42027-42032 Protein denotes NFAT5
T28309 42053-42062 Entity denotes monocytes
T28300 42082-42086 Protein denotes TLR2
T28250 42110-42115 Protein denotes NFAT5
T28244 42110-42130 Protein denotes NFAT5 mRNA synthesis
T28247 42134-42143 Entity denotes monocytes
T28276 42181-42194 Protein denotes TLR2-specific
T28294 42195-42201 Entity denotes ligand
T28257 42235-42238 Protein denotes MTb
T28296 42310-42315 Protein denotes NFAT5
T28291 42343-42348 Protein denotes NFAT5
T28260 42343-42353 Protein denotes NFAT5 mRNA
T28324 42343-42364 Gene_expression denotes NFAT5 mRNA expression
T28322 42343-42435 Positive_regulation denotes NFAT5 mRNA expression was significantly increased when the cells were incubated with Pam3Cys
T28277 42398-42407 Entity denotes the cells
T28311 42440-42441 Entity denotes p
T28271 42465-42468 Protein denotes MTb
T28284 42474-42475 Entity denotes p
T28245 42487-42492 Protein denotes MyD88
T28261 42510-42513 Protein denotes MTb
T28330 42524-42548 Gene_expression denotes of NFAT5 gene expression
T28254 42527-42532 Protein denotes NFAT5
T28307 42552-42567 Entity denotes human monocytes
T28326 42569-42684 Gene_expression denotes THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28325 42569-42684 Transcription denotes THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28285 42569-42684 Entity denotes THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28295 42609-42684 Protein denotes lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
T28258 42648-42653 Protein denotes MyD88
T28289 42648-42684 Protein denotes MyD88 or control shRNA targeting GFP
T28269 42681-42684 Protein denotes GFP
T28272 42741-42746 Entity denotes Cells
T28292 42766-42769 Protein denotes MTb
T28302 42786-42803 Entity denotes 1∶1 cells∶bacilli
T28297 42850-42853 Protein denotes RNA
T28312 42868-42885 Protein denotes NFAT5 mRNA levels
T28256 42874-42878 Protein denotes mRNA
T28265 42918-43025 Entity denotes the cells transduced with MyD88-specific shRNA (black bars) compared with the cells transduced with control
T28280 42944-42958 Protein denotes MyD88-specific
T28308 42944-42977 Protein denotes MyD88-specific shRNA (black bars)
T28268 42987-43025 Entity denotes with the cells transduced with control
T28298 43026-43043 Protein denotes shRNA (open bars)
T28331 43077-43093 Regulation denotes of MTb infection
T28255 43080-43083 Protein denotes MTb
T28267 43095-43098 Protein denotes TNF
T28288 43095-43114 Protein denotes TNF and CD86 mRNAs,
T28264 43103-43107 Protein denotes CD86
T28249 43143-43158 Protein denotes MyD88-dependent
T28314 43198-43201 Protein denotes MTb
T28316 43198-43212 Regulation denotes MTb infection,
T28251 43247-43252 Protein denotes IRAK1
T28313 43257-43262 Protein denotes TRAF6
T28252 43280-43283 Protein denotes MTb
T28323 43294-43318 Gene_expression denotes of NFAT5 gene expression
T28278 43297-43302 Protein denotes NFAT5
T28279 43322-43337 Entity denotes human monocytes
T28320 43339-43432 Gene_expression denotes THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28319 43339-43432 Gene_expression denotes THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28318 43339-43432 Transcription denotes THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28275 43339-43432 Entity denotes THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
T28306 43379-43408 Protein denotes lentivirally-delivered IRAK1-
T28305 43412-43426 Protein denotes TRAF6-specific
T28246 43412-43432 Protein denotes TRAF6-specific shRNA
T28328 43489-43525 Transcription denotes THP-1 cells expressing control shRNA
T28327 43489-43525 Gene_expression denotes THP-1 cells expressing control shRNA
T28281 43489-43525 Entity denotes THP-1 cells expressing control shRNA
T28248 43512-43525 Protein denotes control shRNA
T28301 43556-43561 Entity denotes Cells
T28303 43581-43584 Protein denotes MTb
T28290 43645-43648 Protein denotes RNA
T28273 43663-43668 Protein denotes NFAT5
T28315 43663-43679 Gene_expression denotes NFAT5 expression
T28317 43663-43774 Negative_regulation denotes NFAT5 expression was significantly inhibited in the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
T28262 43711-43774 Protein denotes the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
T28263 43752-43761 Protein denotes IRAK1 (C)
T28304 43765-43770 Protein denotes TRAF6
T28259 43775-43780 Protein denotes shRNA
T28282 43803-43811 Entity denotes to cells
T28270 43831-43836 Protein denotes shRNA
T28299 43850-43853 Protein denotes TNF
T28283 43850-43868 Protein denotes TNF and CD86 mRNAs
T28274 43858-43862 Protein denotes CD86
T28253 43892-43897 Protein denotes IRAK1
T28287 43902-43907 Protein denotes TRAF6
T28321 43922-43939 Positive_regulation denotes by PRR activation
T28266 43925-43928 Protein denotes PRR
T16878 43993-44019 Entity denotes The adaptor molecule MyD88
T16817 43993-44019 Protein denotes The adaptor molecule MyD88
T16888 44043-44047 Protein denotes TLR2
T16863 44093-44105 Protein denotes this protein
T16850 44171-44174 Protein denotes MTb
T16891 44185-44209 Gene_expression denotes of NFAT5 gene expression
T16823 44188-44193 Protein denotes NFAT5
T16845 44274-44336 Protein denotes a lentivirally-delivered short hairpin (sh)RNA targeting MyD88
T16851 44331-44336 Protein denotes MyD88
T16854 44348-44351 Protein denotes PCR
T16828 44374-44389 Protein denotes that MyD88 mRNA
T16815 44379-44384 Protein denotes MyD88
T16836 44400-44411 Entity denotes these cells
T16887 44483-44505 Entity denotes THP-1 cells transduced
T16821 44543-44569 Protein denotes GFP shRNA (data not shown)
T16803 44571-44604 Entity denotes These MyD88 knockdown THP-1 cells
T16867 44577-44582 Protein denotes MyD88
T16800 44629-44642 Protein denotes MTb (CDC1551)
T16884 44647-44652 Protein denotes NFAT5
T16877 44647-44664 Protein denotes NFAT5 mRNA levels
T16802 44686-44689 Protein denotes TNF
T16861 44693-44732 Protein denotes a MyD88-dependent gene [21], [54], [55]
T16856 44695-44710 Protein denotes MyD88-dependent
T16826 44768-44771 Protein denotes TNF
T16808 44836-44878 Protein denotes the MyD88-independent gene CD86 [55], [56]
T16807 44836-44878 Protein denotes the MyD88-independent gene CD86 [55], [56]
T16804 44840-44857 Protein denotes MyD88-independent
T16852 44913-44921 Protein denotes of MyD88
T16797 44945-44956 Protein denotes MTb-induced
T16820 44957-44962 Protein denotes NFAT5
T16822 44967-44970 Protein denotes TNF
T16813 44967-44975 Protein denotes TNF mRNA
T16897 44991-45013 Regulation denotes no impact on CD86 mRNA
T16853 45001-45013 Protein denotes on CD86 mRNA
T16855 45004-45008 Protein denotes CD86
T16830 45028-45031 Protein denotes MTb
T16892 45028-45051 Regulation denotes MTb regulation of NFAT5
T16899 45028-45075 Regulation denotes MTb regulation of NFAT5 is dependent upon MyD88
T16864 45043-45051 Protein denotes of NFAT5
T16870 45065-45075 Protein denotes upon MyD88
T16906 45095-45157 Regulation denotes the pathway mediating MTb upregulation of NFAT5 transcription,
T16841 45117-45120 Protein denotes MTb
T16894 45117-45156 Positive_regulation denotes MTb upregulation of NFAT5 transcription
T16839 45137-45142 Protein denotes NFAT5
T16910 45137-45156 Transcription denotes NFAT5 transcription
T16834 45178-45260 Entity denotes THP-1 cells transduced with lentivirally-delivered shRNAs targeting IRAK1 or TRAF6
T16833 45246-45251 Protein denotes IRAK1
T16814 45255-45260 Protein denotes TRAF6
T16824 45276-45285 Entity denotes molecules
T16880 45300-45305 Protein denotes MyD88
T16886 45356-45361 Protein denotes IRAK1
T16799 45366-45371 Protein denotes TRAF6
T16917 45372-45399 Negative_regulation denotes significantly inhibited MTb
T16827 45372-45399 Protein denotes significantly inhibited MTb
T16865 45408-45413 Protein denotes NFAT5
T16868 45408-45425 Protein denotes NFAT5 mRNA levels
T16866 45440-45451 Protein denotes MTb-induced
T16908 45440-45471 Gene_expression denotes MTb-induced TNF gene expression
T16875 45452-45455 Protein denotes TNF
T16809 45547-45552 Protein denotes IRAK1
T16806 45547-45574 Protein denotes IRAK1 and TRAF6 in TNF gene
T16895 45547-45585 Gene_expression denotes IRAK1 and TRAF6 in TNF gene expression
T16862 45557-45569 Protein denotes TRAF6 in TNF
T16801 45566-45569 Protein denotes TNF
T16871 45599-45602 Protein denotes MTb
T16901 45599-45612 Regulation denotes MTb infection
T16829 45646-45650 Protein denotes CD86
T16916 45646-45666 Gene_expression denotes CD86 gene expression
T16907 45646-45703 Regulation denotes CD86 gene expression did not depend on MyD88 (Figure 7B),
T16818 45682-45703 Protein denotes on MyD88 (Figure 7B),
T16913 45704-45723 Negative_regulation denotes abrogation of IRAK1
T16842 45715-45723 Protein denotes of IRAK1
T16890 45728-45733 Protein denotes TRAF6
T16905 45728-45749 Gene_expression denotes TRAF6 gene expression
T16796 45772-45776 Protein denotes CD86
T16844 45772-45781 Protein denotes CD86 mRNA
T16805 45806-45810 Protein denotes CD86
T16898 45806-45821 Gene_expression denotes CD86 expression
T16849 45825-45831 Protein denotes IRAK1-
T16869 45836-45852 Protein denotes TRAF6-dependent,
T16798 45878-45881 Protein denotes MTb
T16885 45891-45916 Entity denotes monocytes (Figures 7C–7D)
T16909 45924-46014 Positive_regulation denotes together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression
T16857 45973-45976 Protein denotes MTb
T16893 45990-46014 Gene_expression denotes of NFAT5 gene expression
T16846 45993-45998 Protein denotes NFAT5
T16810 46034-46039 Entity denotes cells
T16911 46049-46068 Positive_regulation denotes activation of MyD88
T16881 46060-46068 Protein denotes of MyD88
T16812 46073-46082 Protein denotes the MyD88
T16872 46102-46111 Entity denotes molecules
T16840 46112-46117 Protein denotes IRAK1
T16837 46122-46127 Protein denotes TRAF6
T20813 46141-46171 Protein denotes The transcription factor NFAT5
T20812 46145-46165 Protein denotes transcription factor
T20874 46223-46226 Protein denotes Rel
T20837 46237-46250 Protein denotes NFAT proteins
T20869 46264-46321 Protein denotes the other NFAT proteins (NFATp, NFATc, NFAT3, and NFAT4),
T20780 46289-46320 Protein denotes NFATp, NFATc, NFAT3, and NFAT4)
T20896 46296-46301 Protein denotes NFATc
T20903 46303-46308 Protein denotes NFAT3
T20880 46314-46319 Protein denotes NFAT4
T20825 46322-46327 Protein denotes NFAT5
T20909 46322-46431 Binding denotes NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,
T20770 46334-46337 Entity denotes DNA
T20820 46341-46431 Entity denotes an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,
T20771 46383-46388 Protein denotes NF-κB
T20763 46383-46402 Protein denotes NF-κB proteins [58]
T20784 46407-46418 Protein denotes calcineurin
T20849 46455-46512 Protein denotes with the basic region-leucine zipper proteins Fos and Jun
T20873 46501-46504 Protein denotes Fos
T20877 46516-46520 Protein denotes gene
T20918 46516-46531 Positive_regulation denotes gene activation
T20907 46594-46686 Regulation denotes integrin activation, and T cell-stimulation have been shown to regulate NFAT5 activity [59],
T20766 46619-46637 Entity denotes T cell-stimulation
T20797 46666-46671 Protein denotes NFAT5
T20801 46771-46774 Protein denotes MTb
T20929 46771-46784 Regulation denotes MTb infection
T20875 46793-46808 Protein denotes MyD88-dependent
T20926 46793-46847 Positive_regulation denotes MyD88-dependent upregulation of NFAT5 gene expression,
T20919 46793-46847 Regulation denotes MyD88-dependent upregulation of NFAT5 gene expression,
T20948 46822-46846 Gene_expression denotes of NFAT5 gene expression
T20755 46825-46830 Protein denotes NFAT5
T20781 46886-46889 Protein denotes MTb
T20870 46952-46966 Protein denotes MTb-stimulated
T20936 46952-46988 Positive_regulation denotes MTb-stimulated HIV-1 gene expression
T20878 47005-47008 Protein denotes MTb
T20942 47064-47098 Binding denotes a direct interaction between NFAT5
T20804 47085-47098 Protein denotes between NFAT5
T20889 47113-47121 Entity denotes promoter
T20933 47123-47154 Regulation denotes Thus, HIV-1 has co-opted NFAT5,
T20844 47148-47154 Protein denotes NFAT5,
T20761 47263-47268 Protein denotes NF-κB
T20920 47263-47321 Positive_regulation denotes NF-κB is activated after MTb engagement of PRRs [20], [66]
T20800 47288-47321 Protein denotes MTb engagement of PRRs [20], [66]
T20786 47306-47321 Protein denotes PRRs [20], [66]
T20912 47323-47428 Binding denotes Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer
T20872 47396-47428 Protein denotes of the NF-κB p50/p65 heterodimer
T20762 47396-47428 Entity denotes of the NF-κB p50/p65 heterodimer
T20814 47403-47408 Protein denotes NF-κB
T20796 47486-47490 Protein denotes gene
T20923 47486-47504 Transcription denotes gene transcription
T20876 47568-47573 Protein denotes NF-κB
T20785 47607-47618 Entity denotes of histones
T20808 47649-47654 Protein denotes nuc-1
T20910 47705-47740 Binding denotes in recruitment of the pTEFb complex
T20854 47720-47740 Entity denotes of the pTEFb complex
T20776 47720-47740 Entity denotes of the pTEFb complex
T20831 47764-47767 Protein denotes RNA
T20851 47764-47787 Protein denotes RNA pol II processivity
T20788 47878-47883 Protein denotes NFAT5
T20897 47894-47901 Protein denotes p50/p65
T20840 47894-47901 Protein denotes p50/p65
T20839 47898-47901 Protein denotes p65
T20911 47954-47973 Regulation denotes by MTb co-infection
T20905 47957-47960 Protein denotes MTb
T20848 47980-47985 Protein denotes NF-κB
T20807 47996-48007 Entity denotes the nucleus
T20892 48056-48084 Entity denotes of the NFAT5 binding site(s)
T20921 48056-48084 Binding denotes of the NFAT5 binding site(s)
T20806 48063-48068 Protein denotes NFAT5
T20832 48088-48097 Entity denotes R5-tropic
T20850 48192-48196 Entity denotes PBMC
T20816 48200-48203 Protein denotes MDM
T20798 48243-48246 Protein denotes MTb
T20938 48330-48357 Binding denotes of NFAT5 binding to the LTR
T20829 48333-48338 Protein denotes NFAT5
T20856 48378-48381 Protein denotes MTb
T20908 48378-48394 Regulation denotes MTb co-infection
T20828 48410-48430 Entity denotes an intact NFAT5 site
T20789 48420-48425 Protein denotes NFAT5
T20836 48467-48489 Entity denotes of the two NF-κB sites
T20774 48478-48483 Protein denotes NF-κB
T20881 48527-48538 Protein denotes MTb-induced
T20922 48605-48624 Regulation denotes of MTb co-infection
T20863 48608-48611 Protein denotes MTb
T20823 48637-48653 Entity denotes of NF-κB site II
T20772 48637-48653 Entity denotes of NF-κB site II
T20858 48640-48645 Protein denotes NF-κB
T20769 48736-48783 Entity denotes of NF-κB site I. Consistent with these findings
T20886 48739-48744 Protein denotes NF-κB
T20815 48838-48853 Entity denotes these two sites
T20944 48900-48940 Binding denotes The downstream NF-κB site I binding site
T20846 48900-48940 Entity denotes The downstream NF-κB site I binding site
T20810 48900-48940 Entity denotes The downstream NF-κB site I binding site
T20792 48900-48940 Protein denotes The downstream NF-κB site I binding site
T20939 48998-49012 Binding denotes binding sites,
T20782 48998-49012 Entity denotes binding sites,
T20941 49021-49075 Positive_regulation denotes to enhance Sp protein recruitment to the LTR [71]–[73]
T20833 49035-49042 Protein denotes protein
T20945 49035-49075 Binding denotes protein recruitment to the LTR [71]–[73]
T20893 49085-49090 Protein denotes NF-κB
T20866 49085-49097 Entity denotes NF-κB site I
T20890 49107-49116 Protein denotes the NFAT5
T20778 49125-49129 Entity denotes site
T20764 49176-49185 Entity denotes this site
T20853 49221-49236 Protein denotes increased NFAT5
T20891 49245-49264 Entity denotes to the mutated site
T20927 49296-49392 Negative_regulation denotes with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
T20867 49305-49325 Protein denotes quantitative DNase I
T20783 49384-49392 Protein denotes of NF-κB
T20817 49393-49399 Entity denotes site I
T20928 49408-49447 Positive_regulation denotes in enhanced binding of NFAT5 to the LTR
T20916 49408-49447 Binding denotes in enhanced binding of NFAT5 to the LTR
T20894 49428-49436 Protein denotes of NFAT5
T20765 49579-49614 Protein denotes of endemic TB [1], [2], [28], [52],
T20775 49653-49678 Entity denotes three NF-κB binding sites
T20843 49709-49715 Protein denotes of MTb
T20790 50043-50070 Protein denotes reporter gene transcription
T20852 50207-50210 Protein denotes MTb
T20835 50274-50297 Entity denotes peripheral blood cells,
T20915 50298-50359 Negative_regulation denotes we found that specific disruption of NFAT5 binding to the LTR
T20932 50332-50359 Binding denotes of NFAT5 binding to the LTR
T20826 50335-50340 Protein denotes NFAT5
T20862 50408-50411 Protein denotes MTb
T20937 50408-50425 Regulation denotes MTb co-infection,
T20883 50460-50496 Protein denotes of three intact NF-κB binding sites,
T20934 50576-50596 Binding denotes of NFAT5 recruitment
T20884 50579-50584 Protein denotes NFAT5
T20802 50629-50635 Protein denotes of MTb
T20787 50665-50670 Protein denotes NF-κB
T20803 50675-50680 Protein denotes NFAT5
T20855 50712-50717 Protein denotes NF-κB
T20868 50722-50727 Protein denotes NFAT5
T20756 50767-50782 Entity denotes site in the LTR
T20904 50827-50830 Protein denotes MTb
T20906 50827-50840 Regulation denotes MTb infection
T20895 50850-50855 Protein denotes NFAT5
T20865 50963-50985 Protein denotes the host factors NF-κB
T20914 50963-51044 Binding denotes the host factors NF-κB and NFAT5 associate with the LTR at different stages after
T20913 50963-51044 Binding denotes the host factors NF-κB and NFAT5 associate with the LTR at different stages after
T20847 50990-50995 Protein denotes NFAT5
T20822 51069-51074 Protein denotes NF-κB
T20882 51087-51098 Entity denotes the nucleus
T20799 51126-51129 Protein denotes MTb
T20924 51126-51151 Regulation denotes MTb infection [74], [75],
T20824 51152-51157 Protein denotes NFAT5
T20899 51181-51261 Protein denotes NFAT5, which is pivotal for HIV-1 transcription in unstimulated cells [31], may,
T20827 51232-51255 Entity denotes unstimulated cells [31]
T20838 51268-51271 Protein denotes Mtb
T20940 51268-51282 Regulation denotes Mtb infection,
T20900 51336-51341 Protein denotes NF-κB
T20821 51352-51355 Protein denotes Tat
T20885 51474-51479 Protein denotes NFAT5
T20925 51474-51585 Binding denotes NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
T20759 51486-51523 Entity denotes to the aldose reductase (AR) promoter
T20818 51493-51514 Protein denotes aldose reductase (AR)
T20861 51511-51513 Protein denotes AR
T20888 51562-51573 Protein denotes histones H3
T20841 51644-51665 Entity denotes duct epithelial cells
T20777 51677-51682 Protein denotes NFAT5
T20767 51687-51700 Entity denotes NF-κB complex
T20753 51714-51729 Protein denotes NF-κB-dependent
T20805 51714-51734 Protein denotes NF-κB-dependent gene
T20898 51735-51749 Entity denotes promoters [77]
T20793 51797-51802 Protein denotes NFAT5
T20773 51847-51854 Entity denotes histone
T20757 51886-51894 Protein denotes to NF-κB
T20931 51929-51987 Binding denotes by directly interacting with NF-κB in a cooperative manner
T20857 51953-51963 Protein denotes with NF-κB
T20871 52025-52035 Protein denotes that NFAT5
T20809 52135-52160 Protein denotes MTb-co-infection of human
T20794 52161-52165 Entity denotes PBMC
T20879 52170-52173 Protein denotes MDM
T20943 52175-52222 Binding denotes Functional NF-κB interaction with the viral LTR
T20791 52186-52191 Protein denotes NF-κB
T20949 52319-52339 Binding denotes of NFAT5 recruitment
T20859 52322-52327 Protein denotes NFAT5
T20860 52343-52361 Entity denotes the viral promoter
T20946 52397-52415 Regulation denotes that MTb infection
T20901 52402-52405 Protein denotes MTb
T20864 52436-52451 Entity denotes the TLR2 ligand
T20819 52440-52444 Protein denotes TLR2
T20834 52469-52474 Protein denotes NFAT5
T20947 52469-52490 Gene_expression denotes NFAT5 gene expression
T20811 52494-52509 Entity denotes human monocytes
T20935 52524-52567 Positive_regulation denotes we have shown that MTb stimulation of NFAT5
T20845 52543-52546 Protein denotes MTb
T20795 52562-52567 Protein denotes NFAT5
T20842 52601-52610 Entity denotes molecules
T20779 52622-52635 Protein denotes MyD88, IRAK1,
T20754 52629-52634 Protein denotes IRAK1
T20768 52640-52645 Protein denotes TRAF6
T20760 52758-52761 Protein denotes MTb
T20917 52758-52771 Regulation denotes MTb infection
T20887 52788-52793 Protein denotes NFAT5
T20758 52867-52871 Protein denotes gene
T20930 52867-52882 Regulation denotes gene regulation
T20830 52922-52941 Protein denotes TLR-regulated genes
T20902 52996-52999 Protein denotes MTb
R10130 T13578 T13648 themeOf MTb,by MTb co-infection
R10131 T13583 T13658 themeOf NF-κB,NF-κB is efficiently activated in primary MDM in response to TLR agonists [51]
R10132 T13584 T13655 themeOf MTb,of MTb co-infection
R10133 T13594 T13650 themeOf NFAT5,the conserved NFAT5 binding site
R10134 T13600 T13653 themeOf NFAT5,NFAT5 gene expression
R10135 T13612 T13657 themeOf MTb,of MTb co-infection
R10136 T13616 T13652 themeOf MTb,"of MTb co-infection, consistent with important roles for both NF-κB and NFAT5 in MTb-induced HIV-1 replication"
R10137 T13623 T13656 themeOf MDM,MDM co-infection
R10138 T13632 T13647 themeOf the conserved NFAT5 binding site,the conserved NFAT5 binding site
R10139 T13646 T13651 themeOf MTb,of MTb co-infection
R10803 T14445 T14475 themeOf MTb,MTb co-infection
R10804 T14453 T14478 themeOf NFAT5,of NFAT5 binding to the LTR
R10805 T14458 T14482 themeOf MTb,MTb co-infection
R10806 T14459 T14477 themeOf MTb,MTb infection
R10807 T14461 T14479 themeOf the two NFAT5 binding sites,the two NFAT5 binding sites
R10808 T14469 T14476 themeOf of NFAT5 binding sites,of NFAT5 binding sites
R10809 T14470 T14474 themeOf MTb,MTb co-infection
R10810 T14472 T14481 themeOf two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A),two NFAT5 binding sites in its LTR and three NF-κB sites (Figure 6A)
R10811 T14478 T14480 themeOf of NFAT5 binding to the LTR,disruption of NFAT5 binding to the LTR
R12431 T16805 T16898 themeOf CD86,CD86 expression
R12432 T16806 T16895 themeOf IRAK1 and TRAF6 in TNF gene,IRAK1 and TRAF6 in TNF gene expression
R12433 T16816 T16902 themeOf MTb,actual MTb infection
R12434 T16818 T16907 causeOf "on MyD88 (Figure 7B),","CD86 gene expression did not depend on MyD88 (Figure 7B),"
R12435 T16819 T16903 causeOf MTb,MTb stimulation of NFAT5 gene expression
R12436 T16823 T16891 themeOf NFAT5,of NFAT5 gene expression
R12437 T16825 T16915 themeOf NFAT5,on NFAT5 gene expression (Figure 7A)
R12438 T16827 T16917 themeOf significantly inhibited MTb,significantly inhibited MTb
R12439 T16829 T16916 themeOf CD86,CD86 gene expression
R12440 T16830 T16892 causeOf MTb,MTb regulation of NFAT5
R12441 T16835 T16914 themeOf additional PRRs,that additional PRRs may be triggered during actual MTb infection
R12442 T16839 T16910 themeOf NFAT5,NFAT5 transcription
R12443 T16841 T16894 themeOf MTb,MTb upregulation of NFAT5 transcription
R12444 T16842 T16913 themeOf of IRAK1,abrogation of IRAK1
R12445 T16846 T16893 themeOf NFAT5,of NFAT5 gene expression
R12446 T16848 T16896 themeOf NFAT5,NFAT5 gene expression
R12447 T16853 T16897 themeOf on CD86 mRNA,no impact on CD86 mRNA
R12448 T16857 T16909 causeOf MTb,"together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression"
R12449 T16860 T16904 themeOf NFAT5,of NFAT5 gene expression
R12450 T16864 T16892 themeOf of NFAT5,MTb regulation of NFAT5
R12451 T16870 T16899 causeOf upon MyD88,MTb regulation of NFAT5 is dependent upon MyD88
R12452 T16871 T16901 themeOf MTb,MTb infection
R12453 T16875 T16908 themeOf TNF,MTb-induced TNF gene expression
R12454 T16881 T16911 themeOf of MyD88,activation of MyD88
R12455 T16882 T16912 themeOf MTb,MTb infection
R12456 T16890 T16905 themeOf TRAF6,TRAF6 gene expression
R12457 T16892 T16899 themeOf MTb regulation of NFAT5,MTb regulation of NFAT5 is dependent upon MyD88
R12458 T16893 T16909 themeOf of NFAT5 gene expression,"together, these results clearly demonstrate that MTb upregulation of NFAT5 gene expression"
R12459 T16894 T16906 themeOf MTb upregulation of NFAT5 transcription,"the pathway mediating MTb upregulation of NFAT5 transcription,"
R12460 T16904 T16903 themeOf of NFAT5 gene expression,MTb stimulation of NFAT5 gene expression
R12461 T16916 T16907 themeOf CD86 gene expression,"CD86 gene expression did not depend on MyD88 (Figure 7B),"
R15368 T20755 T20948 themeOf NFAT5,of NFAT5 gene expression
R15369 T20758 T20930 themeOf gene,gene regulation
R15370 T20759 T20818 partOf to the aldose reductase (AR) promoter,aldose reductase (AR)
R15372 T20759 T20925 themeOf to the aldose reductase (AR) promoter,NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
R15373 T20760 T20917 themeOf MTb,MTb infection
R15374 T20761 T20920 themeOf NF-κB,"NF-κB is activated after MTb engagement of PRRs [20], [66]"
R15376 T20762 T20912 themeOf of the NF-κB p50/p65 heterodimer,Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer
R15381 T20770 T20909 themeOf DNA,"NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,"
R15392 T20776 T20910 themeOf of the pTEFb complex,in recruitment of the pTEFb complex
R15402 T20782 T20939 themeOf "binding sites,","binding sites,"
R15410 T20783 T20927 themeOf of NF-κB,with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
R15412 T20791 T20943 themeOf NF-κB,Functional NF-κB interaction with the viral LTR
R15415 T20796 T20923 themeOf gene,gene transcription
R15418 T20799 T20924 themeOf MTb,"MTb infection [74], [75],"
R15420 T20801 T20929 themeOf MTb,MTb infection
R15421 T20804 T20942 themeOf between NFAT5,a direct interaction between NFAT5
R15424 T20825 T20909 themeOf NFAT5,"NFAT5 binds DNA as an obligate dimer in a fashion resembling NF-κB proteins [58], is calcineurin independent,"
R15425 T20833 T20945 themeOf protein,protein recruitment to the LTR [71]–[73]
R15426 T20834 T20947 themeOf NFAT5,NFAT5 gene expression
R15427 T20838 T20940 themeOf Mtb,"Mtb infection,"
R15428 T20826 T20932 themeOf NFAT5,of NFAT5 binding to the LTR
R15429 T20829 T20938 themeOf NFAT5,of NFAT5 binding to the LTR
R15430 T20844 T20933 themeOf "NFAT5,","Thus, HIV-1 has co-opted NFAT5,"
R15431 T20845 T20935 themeOf MTb,we have shown that MTb stimulation of NFAT5
R15432 T20945 T20941 themeOf protein recruitment to the LTR [71]–[73],to enhance Sp protein recruitment to the LTR [71]–[73]
R15433 T20846 T20944 themeOf The downstream NF-κB site I binding site,The downstream NF-κB site I binding site
R15434 T20847 T20913 themeOf NFAT5,the host factors NF-κB and NFAT5 associate with the LTR at different stages after
R15435 T20856 T20908 themeOf MTb,MTb co-infection
R15436 T20857 T20931 themeOf with NF-κB,by directly interacting with NF-κB in a cooperative manner
R15437 T20859 T20949 themeOf NFAT5,of NFAT5 recruitment
R15438 T20862 T20937 themeOf MTb,"MTb co-infection,"
R15439 T20863 T20922 themeOf MTb,of MTb co-infection
R15440 T20948 T20926 themeOf of NFAT5 gene expression,"MyD88-dependent upregulation of NFAT5 gene expression,"
R15441 T20865 T20914 themeOf the host factors NF-κB,the host factors NF-κB and NFAT5 associate with the LTR at different stages after
R15442 T20867 T20927 causeOf quantitative DNase I,with our quantitative DNase I footprinting analysis that shows that specific disruption of NF-κB
R15443 T20870 T20936 causeOf MTb-stimulated,MTb-stimulated HIV-1 gene expression
R15444 T20875 T20919 causeOf MyD88-dependent,"MyD88-dependent upregulation of NFAT5 gene expression,"
R15445 T20877 T20918 themeOf gene,gene activation
R15446 T20884 T20934 themeOf NFAT5,of NFAT5 recruitment
R15447 T20885 T20925 themeOf NFAT5,NFAT5 binds to the aldose reductase (AR) promoter and induces rapid hyperacetylation of histones H3 and H4 [76]
R15448 T20892 T20921 themeOf of the NFAT5 binding site(s),of the NFAT5 binding site(s)
R15449 T20894 T20916 themeOf of NFAT5,in enhanced binding of NFAT5 to the LTR
R15450 T20901 T20946 themeOf MTb,that MTb infection
R15451 T20904 T20906 themeOf MTb,MTb infection
R15452 T20905 T20911 themeOf MTb,by MTb co-infection
R15453 T20916 T20928 themeOf in enhanced binding of NFAT5 to the LTR,in enhanced binding of NFAT5 to the LTR
R15454 T20926 T20919 themeOf "MyD88-dependent upregulation of NFAT5 gene expression,","MyD88-dependent upregulation of NFAT5 gene expression,"
R15455 T20932 T20915 themeOf of NFAT5 binding to the LTR,we found that specific disruption of NFAT5 binding to the LTR
R16544 T22260 T22307 themeOf of the NFAT5 binding site,of the NFAT5 binding site
R16545 T22261 T22303 themeOf NFAT5,NFAT5 interaction with the LTR
R16546 T22265 T22305 themeOf gene,Specific disruption of the NFAT5 binding site significantly reduces LTR-reporter gene activity in monocytic cells in response to MTb lysate treatment
R16547 T22273 T22308 themeOf of NFAT5,Disruption of NFAT5 binding
R16548 T22278 T22304 themeOf luciferase,Renilla luciferase control expression
R16549 T22284 T22306 themeOf MTb,MTb stimulation
R17513 T23515 T23570 themeOf MTb,MTb infection
R17514 T23536 T23576 themeOf NFAT5,NFAT5 expression
R17515 T23542 T23567 themeOf MTb,MTb co-infection when NFAT5 expression is abrogated
R17516 T23546 T23569 themeOf NFAT5,NFAT5 expression in MDM
R17517 T23548 T23572 themeOf NFAT5,NFAT5 gene expression
R17518 T23552 T23575 themeOf MTb,MTb co-infection
R17519 T23554 T23574 themeOf MTb,of MTb co-infection
R17520 T23557 T23565 themeOf NFAT5,NFAT5 expression
R17521 T23565 T23568 themeOf NFAT5 expression,MTb infection significantly increased NFAT5 expression in comparison to uninfected
R17522 T23569 T23573 themeOf NFAT5 expression in MDM,effectively suppresses NFAT5 expression in MDM in both the absence and presence of MTb co-infection
R17523 T23570 T23568 causeOf MTb infection,MTb infection significantly increased NFAT5 expression in comparison to uninfected
R17524 T23576 T23566 themeOf NFAT5 expression,when NFAT5 expression is abrogated
R18435 T25143 T25197 themeOf NFAT5,Specific disruption of NFAT5 or NF-κB binding sites in the LTR of HIV-1 subtype B
R18436 T25157 T25192 causeOf NF-κB binding sites,NF-κB binding sites effectively abrogates recombinant p50/p65 binding
R18437 T25157 T25193 themeOf NF-κB binding sites,NF-κB binding sites
R18438 T25162 T25188 themeOf p50/p65,recombinant p50/p65 binding
R18439 T25165 T25189 themeOf NFAT5,NFAT5 binding
R18440 T25170 T25190 themeOf NFAT5,of the NFAT5 binding
R18441 T25175 T25196 themeOf NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut),NFAT5 binding site mutant (HIV-1Lai/Bal-env-N5-Mut)
R18442 T25177 T25198 themeOf NFAT5,NFAT5 binding
R18443 T25180 T25195 themeOf NF-κB p50/p65 binding to the overlapping NF-κB binding site,NF-κB p50/p65 binding to the overlapping NF-κB binding site
R18444 T25188 T25192 themeOf recombinant p50/p65 binding,NF-κB binding sites effectively abrogates recombinant p50/p65 binding
R18445 T25189 T25191 themeOf NFAT5 binding,enhances NFAT5 binding to this region
R18838 T25795 T25811 themeOf NF-κB,on binding of NFAT5 and NF-κB
R18839 T25797 T25813 themeOf MTb co-infected (black bars),MTb co-infected (black bars)
R18840 T25799 T25812 themeOf of the NF-κB or NFAT5 binding sites,of the NF-κB or NFAT5 binding sites
R18841 T25802 T25814 themeOf MTb,"MTb co-infection,"
R18842 T25804 T25811 themeOf NFAT5,on binding of NFAT5 and NF-κB
R19550 T26785 T26803 themeOf MTb,MTb co-infection
R19551 T26791 T26800 themeOf The NFAT5 binding site mutant (HIV-198IN22 N5-Mut),The NFAT5 binding site mutant (HIV-198IN22 N5-Mut)
R19552 T26794 T26801 themeOf of the NFAT5 binding site,of the NFAT5 binding site
R20606 T28246 T28318 themeOf TRAF6-specific shRNA,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20607 T28246 T28319 themeOf TRAF6-specific shRNA,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20608 T28248 T28327 themeOf control shRNA,THP-1 cells expressing control shRNA
R20609 T28248 T28328 themeOf control shRNA,THP-1 cells expressing control shRNA
R20610 T28254 T28330 themeOf NFAT5,of NFAT5 gene expression
R20611 T28255 T28331 themeOf MTb,of MTb infection
R20612 T28260 T28324 themeOf NFAT5 mRNA,NFAT5 mRNA expression
R20613 T28266 T28321 themeOf PRR,by PRR activation
R20614 T28273 T28315 themeOf NFAT5,NFAT5 expression
R20615 T28278 T28323 themeOf NFAT5,of NFAT5 gene expression
R20616 T28286 T28329 themeOf NFAT5,of NFAT5 expression
R20617 T28295 T28325 themeOf lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP,THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
R20618 T28295 T28326 themeOf lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP,THP-1 cells that constitutively express lentivirally-delivered shRNA targeting MyD88 or control shRNA targeting GFP
R20619 T28306 T28320 themeOf lentivirally-delivered IRAK1-,THP-1 cells that constitutively express lentivirally-delivered IRAK1- or TRAF6-specific shRNA
R20620 T28314 T28316 themeOf MTb,"MTb infection,"
R20621 T28315 T28317 themeOf NFAT5 expression,NFAT5 expression was significantly inhibited in the MTb-infected cells expressing either IRAK1 (C) or TRAF6 (D)
R20622 T28324 T28322 themeOf NFAT5 mRNA expression,NFAT5 mRNA expression was significantly increased when the cells were incubated with Pam3Cys
R2107 T2697 T2785 locationOf monocytic cells,The primary PRR on monocytic cells triggered by MTb infection
R2120 T2703 T2782 themeOf IκB kinase (IKK) and mitogen-activated protein (MAP) kinases,TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
R2134 T2707 T2787 causeOf mitogen-activated,mitogen-activated protein (MAP)
R2142 T2714 T2778 themeOf MTb,by MTb infection
R2143 T2721 T2780 themeOf MTb,MTb infection
R2144 T2723 T2773 themeOf NFAT5,of NFAT5 expression
R2145 T2725 T2779 locationOf core,the core NF-κB binding motifs in the LTR
R2146 T2726 T2775 causeOf MyD88,"MyD88 signaling, [32],"
R2147 T2729 T2776 themeOf of specific transcription factor,activation of specific transcription factor
R2148 T2730 T2784 themeOf "several kinases, including IRAK1 and IRAK4,","the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6"
R2149 T2739 T2782 causeOf TRAF6,TRAF6 activates IκB kinase (IKK) and mitogen-activated protein (MAP) kinases
R2150 T2742 T2783 themeOf "NF-κB binding sites, respectively [1], [28]","NF-κB binding sites, respectively [1], [28]"
R2151 T2753 T2787 themeOf mitogen-activated protein (MAP),mitogen-activated protein (MAP)
R2152 T2759 T2786 themeOf MTb,MTb infection
R2153 T2760 T2779 themeOf the core NF-κB binding motifs in the LTR,the core NF-κB binding motifs in the LTR
R2154 T2761 T2781 themeOf MTb,"of latent MTb reactivation,"
R2155 T2764 T2784 themeOf the ubiquitin ligase TRAF6,"the subsequent recruitment of several kinases, including IRAK1 and IRAK4, and the ubiquitin ligase TRAF6"
R2156 T2767 T2774 themeOf NFAT5,NFAT5 gene expression in human monocytes
R2157 T2769 T2777 themeOf The primary PRR on monocytic cells triggered by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2158 T2769 T2785 themeOf The primary PRR on monocytic cells triggered by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2159 T2774 T2772 themeOf NFAT5 gene expression in human monocytes,we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
R2160 T2778 T2777 causeOf by MTb infection,The primary PRR on monocytic cells triggered by MTb infection
R2161 T2780 T2772 causeOf MTb infection,we demonstrate that MTb infection increases NFAT5 gene expression in human monocytes in a MyD88-dependent manner
R3390 T4295 T4301 themeOf Recombinant p50,Recombinant p50 and p65 were purchased
R3391 T4296 T4301 themeOf p65,Recombinant p50 and p65 were purchased
R3971 T5029 T5034 themeOf NFAT5,NFAT5 expression
R4408 T5569 T5591 themeOf shRNA,Stable THP-1 cells expressing shRNA
R4409 T5569 T5592 themeOf shRNA,Stable THP-1 cells expressing shRNA
R454 T811 T819 themeOf MTb-mediated control of gene expression,MTb-mediated control of gene expression
R455 T812 T813 themeOf of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R456 T815 T814 themeOf interaction with the viral promoter,in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
R457 T817 T820 themeOf MTb-induced NFAT5 gene expression,"MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R4770 T5981 T5984 themeOf of primary MDM,infection of primary MDM
R5355 T6672 T6673 themeOf mRNA,The mRNA expression levels
R5356 T6672 T6674 themeOf mRNA,The mRNA expression levels
R5840 T7242 T7250 themeOf to the firefly luciferase reporter gene,linked to the firefly luciferase reporter gene
R5841 T7249 T7251 themeOf MTb,of MTb stimulation
R596 T779 T822 themeOf MTb,MTb infection
R597 T781 T820 causeOf "MyD88, IRAK1, and TRAF6,","MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R598 T785 T815 themeOf with the viral promoter,interaction with the viral promoter
R599 T789 T819 causeOf MTb-mediated,MTb-mediated control of gene expression
R600 T790 T823 themeOf an intact NFAT5 binding site,an intact NFAT5 binding site
R601 T793 T818 themeOf protein,protein expression
R602 T794 T817 themeOf NFAT5,MTb-induced NFAT5 gene expression
R603 T795 T812 themeOf of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R604 T795 T821 themeOf of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R605 T797 T821 causeOf nuclear factor of activated T cells 5 (NFAT5),of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R606 T806 T816 themeOf protein,protein expression
R6466 T8050 T8075 themeOf of NF-κB unperturbed,binding of NF-κB unperturbed [31]
R6467 T8051 T8078 themeOf the NFAT5 binding site,the NFAT5 binding site
R6468 T8064 T8080 themeOf of the NFAT5 binding site-mutant,of the NFAT5 binding site-mutant
R6469 T8065 T8076 themeOf of NFAT5,the binding of NFAT5
R6470 T8069 T8079 themeOf NFAT5,NFAT5 expression
R6471 T8070 T8077 themeOf MTb,MTb stimulation
R6472 T8079 T8081 themeOf NFAT5 expression,MTb lysate stimulation directly enhances NFAT5 expression
R6979 T8712 T8742 causeOf MTb,"Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM"
R6980 T8714 T8743 themeOf NFAT5 mRNA,NFAT5 mRNA expression
R6981 T8715 T8740 themeOf MDM,infecting MDM with live or heat-inactivated R5-tropic
R6982 T8717 T8738 themeOf NFAT5,NFAT5 gene expression levels by quantitative real-time PCR at 24 and 48 hours
R6983 T8723 T8741 themeOf NFAT5 mRNA,NFAT5 mRNA expression
R6984 T8741 T8742 themeOf NFAT5 mRNA expression,"Thus, MTb specifically enhances NFAT5 mRNA expression in human MDM"
R6985 T8743 T8739 themeOf NFAT5 mRNA expression,to directly enhance NFAT5 mRNA expression in primary human MDM
R8059 T10195 T10255 themeOf NFAT5,of NFAT5 inhibition
R8060 T10198 T10254 themeOf MDM co-infected with a subtype B,MDM co-infected with a subtype B
R8061 T10207 T10253 themeOf NFAT5,NFAT5 expression
R9344 T12042 T12114 themeOf NFAT5,NFAT5 binding to the HIV-1 LTR
R9345 T12043 T12113 themeOf MTb,the HIV-1 LTR on MTb regulation
R9346 T12044 T12126 themeOf of NFAT5,of recruitment of NFAT5
R9347 T12057 T12117 themeOf p50/p65,of p50/p65 binding to the LTR
R9348 T12061 T12119 themeOf the NFAT5 binding site,the NFAT5 binding site
R9349 T12076 T12120 themeOf NFAT5,NFAT5 binding
R9350 T12080 T12115 themeOf p50/p65,binding of NFAT5 or NF-κB p50/p65 to their respective motifs
R9351 T12086 T12125 themeOf p50/p65,p50/p65 binding
R9352 T12090 T12112 themeOf NFAT5,"shown in Figure 3B, the N5-Mut LTR could not bind NFAT5"
R9353 T12094 T12116 themeOf p50/p65,p50/p65 binding
R9354 T12107 T12124 themeOf p50/p65,"NFAT5 and NF-κB p50/p65 binding to the LTR,"
R9355 T12115 T12123 themeOf binding of NFAT5 or NF-κB p50/p65 to their respective motifs,"Thus, binding of NFAT5 or NF-κB p50/p65 to their respective motifs can be specifically disrupted"
R9356 T12117 T12122 themeOf of p50/p65 binding to the LTR,in abrogation of p50/p65 binding to the LTR
R9357 T12120 T12118 themeOf NFAT5 binding,disrupt NFAT5 binding
R9358 T12125 T12121 themeOf p50/p65 binding,p50/p65 binding was not impaired
R9359 T12126 T12127 themeOf of recruitment of NFAT5,modulation of recruitment of NFAT5