bionlp-st-ge-2016-test-ihmc  

PMC:3317373 / 15417-20739 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Speculation
T10091 73-119 Positive_regulation denotes the upregulation of NF-κB DNA binding activity
T9967 93-98 Protein denotes NF-κB
T10073 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10072 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10071 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10070 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10069 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10068 124-193 Positive_regulation denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10067 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T10066 124-193 Gene_expression denotes overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes
T9974 142-147 Protein denotes TNF-α
T10008 149-154 Protein denotes IL-1β
T10009 156-160 Protein denotes IL-6
T9965 166-170 Protein denotes MMP9
T9990 174-193 Entity denotes cultured astrocytes
T10096 217-317 Positive_regulation denotes scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines
T9942 256-264 Protein denotes of NF-κB
T10074 278-317 Gene_expression denotes expression of proinflammatory cytokines
T10014 289-317 Protein denotes of proinflammatory cytokines
T10050 344-354 Entity denotes astrocytes
T10036 369-407 Entity denotes wildtype astrocytes for the first time
T9947 434-444 Protein denotes that NF-κB
T10075 434-505 Positive_regulation denotes that NF-κB is activated in brain and spinal cord after traumatic injury
T9952 517-529 Protein denotes a transcript
T10034 538-543 Protein denotes NF-κB
T10054 538-580 Binding denotes NF-κB binds with DNA once it was activated
T10002 550-558 Entity denotes with DNA
T10064 593-614 Transcription denotes transcription of MMP9
T9960 607-614 Protein denotes of MMP9
T9940 648-691 Protein denotes cytokines, including TNF-α, IL-1β, and IL-6
T10027 669-674 Protein denotes TNF-α
T9948 676-681 Protein denotes IL-1β
T9984 687-691 Protein denotes IL-6
T9996 800-851 Protein denotes NF-κB DNA binding activity, overexpression of MMP9,
T10037 843-851 Protein denotes of MMP9,
T10035 901-920 Entity denotes cultured astrocytes
T10042 1036-1041 Protein denotes TNF-α
T9979 1046-1051 Protein denotes IL-1β
T9941 1079-1083 Protein denotes MMP9
T9953 1087-1102 Entity denotes astrocytes [12,
T9962 1112-1116 Protein denotes IL-6
T10098 1125-1147 Positive_regulation denotes overexpression of MMP9
T10097 1125-1147 Gene_expression denotes overexpression of MMP9
T9957 1140-1147 Protein denotes of MMP9
T9983 1189-1194 Protein denotes TNF-α
T9981 1199-1204 Protein denotes IL-1β
T10055 1221-1249 Positive_regulation denotes activation of NF-κB [15, 16]
T10015 1232-1240 Protein denotes of NF-κB
T10058 1587-1620 Binding denotes accumulation of toxic metabolites
T10020 1600-1620 Entity denotes of toxic metabolites
T10030 1700-1723 Protein denotes of Nrf2 in brain tissue
T10065 1700-1724 Localization denotes of Nrf2 in brain tissue
T9995 1801-1812 Entity denotes antioxidant
T9968 1801-1819 Protein denotes antioxidant genes,
T10040 1828-1851 Protein denotes heme oxygenase-1 (HO-1)
T10016 1828-1898 Entity denotes heme oxygenase-1 (HO-1) and NAD (P)H: quinone oxidoreductase-1 (NQO1),
T10021 1846-1850 Protein denotes HO-1
T10049 1856-1863 Entity denotes NAD (P)
T9955 1861-1862 Entity denotes P
T9988 1866-1888 Protein denotes quinone oxidoreductase
T10052 1892-1896 Protein denotes NQO1
T10005 1986-1990 Protein denotes SFN,
T10044 2133-2138 Entity denotes lipid
T9992 2175-2178 Protein denotes CA3
T10000 2238-2257 Protein denotes Nrf2-deficient mice
T10039 2300-2307 Protein denotes of Nrf2
T10084 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10083 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10082 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10081 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10080 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10079 2415-2480 Gene_expression denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10078 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T10077 2415-2480 Positive_regulation denotes that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch
T9946 2438-2443 Protein denotes TNF-α
T10031 2445-2450 Protein denotes IL-1β
T10007 2452-2456 Protein denotes IL-6
T10024 2462-2480 Protein denotes MMP9 after scratch
T9980 2525-2544 Entity denotes knockout astrocytes
T9971 2652-2677 Entity denotes to more astrocytes deaths
T10041 2742-2753 Entity denotes antioxidant
T10006 2761-2768 Protein denotes of Nrf2
T10085 2847-2865 Positive_regulation denotes by NF-κB signaling
T9956 2850-2855 Protein denotes NF-κB
T10003 2885-2888 Protein denotes SFN
T9985 2948-2951 Protein denotes p65
T9945 2948-2987 Protein denotes p65 NF-κB subunit nuclear translocation
T9958 3014-3019 Protein denotes NF-κB
T10076 3014-3029 Positive_regulation denotes NF-κB signaling
T10038 3040-3115 Protein denotes NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by
T10057 3040-3115 Negative_regulation denotes NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by true
T10001 3065-3092 Entity denotes by lipopolysaccharide (LPS)
T10012 3088-3091 Entity denotes LPS
T9998 3129-3139 Entity denotes activators
T9977 3149-3152 Protein denotes SFN
T10051 3157-3171 Entity denotes curcumin (CUR)
T10013 3268-3273 Protein denotes NF-κB
T9966 3432-3451 Entity denotes cultured astrocytes
T10056 3474-3502 Positive_regulation denotes Enhanced activation of NF-κB
T10059 3474-3575 Positive_regulation denotes Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts
T9972 3494-3502 Protein denotes of NF-κB
T9954 3531-3542 Entity denotes macrophages
T10048 3548-3575 Entity denotes mouse embryonic fibroblasts
T10023 3594-3629 Protein denotes mice after experimental sepsis [24]
T10086 3661-3713 Negative_regulation denotes that NF-κB can inhibit Nrf2 at transcriptional level true
T9999 3666-3671 Protein denotes NF-κB
T10011 3684-3688 Protein denotes Nrf2
T9944 3715-3720 Protein denotes NF-κB
T9987 3715-3732 Protein denotes NF-κB p65 subunit
T9949 3816-3839 Entity denotes with the CH1-KIX domain
T9978 3829-3832 Entity denotes KIX
T9975 3843-3846 Protein denotes CBP
T9991 3856-3863 Entity denotes histone
T9963 3957-3962 Protein denotes NF-κB
T9982 3967-3972 Protein denotes Nrf2,
T9969 3996-4065 Protein denotes by the upstream mitogen-activated protein kinase (MAPKs) pathway [26]
T9994 4046-4051 Protein denotes MAPKs
T10043 4094-4098 Protein denotes Nrf2
T10019 4121-4142 Entity denotes nucleus of astrocytes
T10010 4132-4142 Entity denotes astrocytes
T10029 4179-4188 Protein denotes that Nrf2
T10004 4192-4259 Protein denotes a transcription factor which should take function mainly in nucleus
T10045 4252-4259 Entity denotes nucleus
T9939 4285-4295 Entity denotes astrocytes
T9943 4326-4375 Entity denotes cells in activation of Nrf2-ARE pathway after TBI
T10101 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10100 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10099 4403-4466 Gene_expression denotes the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes
T10018 4421-4426 Protein denotes TNF-α
T9986 4428-4433 Protein denotes IL-1β
T9997 4439-4443 Protein denotes IL-6
T9973 4447-4466 Entity denotes cultured astrocytes
T10047 4488-4491 Entity denotes LPS
T9959 4495-4508 Entity denotes oxyhemoglobin
T9993 4587-4591 Protein denotes MMP9
T9938 4592-4611 Entity denotes positive astrocytes
T10033 4705-4718 Entity denotes of astrocytes
T9951 4829-4846 Entity denotes astrocytes, Nrf2,
T9976 4841-4845 Protein denotes Nrf2
T10063 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10062 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10061 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10060 4888-4971 Gene_expression denotes Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10095 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10094 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10093 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T10092 4913-4971 Positive_regulation denotes the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9
T9964 4943-4948 Protein denotes TNF-α
T9970 4950-4955 Protein denotes IL-1β
T10026 4957-4961 Protein denotes IL-6
T10028 4967-4971 Protein denotes MMP9
T10032 4989-4999 Entity denotes astrocytes
T10053 5082-5105 Protein denotes the activation of NF-κB
T10090 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10089 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10088 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T10087 5110-5214 Gene_expression denotes the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch
T9989 5128-5133 Protein denotes TNF-α
T10017 5135-5140 Protein denotes IL-1β
T9950 5142-5146 Protein denotes IL-6
T10022 5152-5156 Protein denotes MMP9
T9961 5190-5200 Entity denotes astrocytes
T10025 5250-5254 Protein denotes Nrf2
T10046 5286-5321 Entity denotes anti-inflammatory therapy after TBI
R8178 T9946 T10077 themeOf TNF-α,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8179 T9946 T10084 themeOf TNF-α,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8180 T9947 T10075 themeOf that NF-κB,that NF-κB is activated in brain and spinal cord after traumatic injury
R8182 T9950 T10087 themeOf IL-6,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8184 T9956 T10085 causeOf NF-κB,by NF-κB signaling
R8187 T9957 T10097 themeOf of MMP9,overexpression of MMP9
R8188 T9957 T10098 themeOf of MMP9,overexpression of MMP9
R8189 T9958 T10076 causeOf NF-κB,NF-κB signaling
R8192 T9960 T10064 themeOf of MMP9,transcription of MMP9
R8195 T9964 T10062 themeOf TNF-α,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8196 T9965 T10066 themeOf MMP9,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8197 T9965 T10071 themeOf MMP9,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8198 T9970 T10061 themeOf IL-1β,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8200 T9972 T10059 themeOf of NF-κB,"Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts"
R8203 T9974 T10070 themeOf TNF-α,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8204 T9974 T10073 themeOf TNF-α,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8207 T10014 T10074 themeOf of proinflammatory cytokines,expression of proinflammatory cytokines
R8208 T10015 T10055 themeOf of NF-κB,"activation of NF-κB [15, 16]"
R8209 T9986 T10101 themeOf IL-1β,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8210 T10017 T10090 themeOf IL-1β,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8211 T9989 T10088 themeOf TNF-α,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8212 T10018 T10099 themeOf TNF-α,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8213 T10022 T10089 themeOf MMP9,"the expression of TNF-α, IL-1β, IL-6, and MMP9 resulting in more cell deaths in astrocytes after scratch"
R8214 T9997 T10100 themeOf IL-6,"the expression of TNF-α, IL-1β, and IL-6 in cultured astrocytes"
R8215 T10024 T10079 themeOf MMP9 after scratch,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8216 T9999 T10086 causeOf NF-κB,that NF-κB can inhibit Nrf2 at transcriptional level
R8217 T10024 T10081 themeOf MMP9 after scratch,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8218 T10002 T10054 themeOf with DNA,NF-κB binds with DNA once it was activated
R8219 T10026 T10060 themeOf IL-6,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8220 T10028 T10063 themeOf MMP9,"Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8221 T10007 T10078 themeOf IL-6,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8222 T10007 T10082 themeOf IL-6,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8223 T10008 T10067 themeOf IL-1β,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8224 T10008 T10069 themeOf IL-1β,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8225 T10009 T10068 themeOf IL-6,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8226 T10009 T10072 themeOf IL-6,"overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes"
R8227 T10011 T10086 themeOf Nrf2,that NF-κB can inhibit Nrf2 at transcriptional level
R8228 T10030 T10065 themeOf of Nrf2 in brain tissue,of Nrf2 in brain tissue
R8229 T10031 T10080 themeOf IL-1β,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8230 T10031 T10083 themeOf IL-1β,"that overexpression of TNF-α, IL-1β, IL-6, and MMP9 after scratch"
R8231 T10034 T10054 themeOf NF-κB,NF-κB binds with DNA once it was activated
R8232 T10038 T10057 causeOf NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by,NF-κB activation induced by lipopolysaccharide (LPS) could be attenuated by
R8233 T10059 T10056 themeOf "Enhanced activation of NF-κB is also discovered in lung, macrophages, and mouse embryonic fibroblasts",Enhanced activation of NF-κB
R8234 T10060 T10094 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8235 T10061 T10095 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8236 T10062 T10092 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8237 T10063 T10093 themeOf "Our results demonstrated the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9","the upregulated expression of TNF-α, IL-1β, IL-6, and MMP9"
R8238 T10074 T10096 themeOf expression of proinflammatory cytokines,scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines