Id |
Subject |
Object |
Predicate |
Lexical cue |
T14368 |
60-65 |
Protein |
denotes |
TNF-α |
T14402 |
60-75 |
Positive_regulation |
denotes |
TNF-α signaling |
T14374 |
114-119 |
Protein |
denotes |
NF-κB |
T14403 |
114-135 |
Phosphorylation |
denotes |
NF-κB phosphorylation |
T14375 |
139-145 |
Entity |
denotes |
the PC |
T14273 |
156-158 |
Entity |
denotes |
SE |
T14335 |
222-232 |
Entity |
denotes |
neutrophil |
T14258 |
374-397 |
Entity |
denotes |
the extracellular space |
T14263 |
615-620 |
Protein |
denotes |
TNF-α |
T14303 |
664-696 |
Entity |
denotes |
microglia in the PC following SE |
T14315 |
677-696 |
Protein |
denotes |
the PC following SE |
T14378 |
694-696 |
Protein |
denotes |
SE |
T14276 |
698-701 |
Protein |
denotes |
TNF |
T14278 |
698-722 |
Protein |
denotes |
TNF receptor expressions |
T14376 |
749-781 |
Entity |
denotes |
astrocytes (TNFp55R and TNFp75R) |
T14381 |
786-813 |
Entity |
denotes |
endothelial cells (TNFp75R) |
T14337 |
805-812 |
Protein |
denotes |
TNFp75R |
T14400 |
837-855 |
Positive_regulation |
denotes |
of TNF-α signaling |
T14287 |
840-845 |
Protein |
denotes |
TNF-α |
T14312 |
856-875 |
Entity |
denotes |
by sTNFp55 infusion |
T14325 |
928-938 |
Entity |
denotes |
SE-induced |
T14354 |
978-984 |
Protein |
denotes |
the PC |
T14350 |
1015-1020 |
Protein |
denotes |
TNF-α |
T14299 |
1080-1083 |
Entity |
denotes |
SE, |
T14261 |
1106-1116 |
Entity |
denotes |
SE-induced |
T14314 |
1158-1163 |
Protein |
denotes |
TNF-α |
T14405 |
1158-1173 |
Positive_regulation |
denotes |
TNF-α signaling |
T14301 |
1268-1284 |
Entity |
denotes |
sTNFp55 infusion |
T14389 |
1314-1324 |
Entity |
denotes |
SE-induced |
T14280 |
1364-1370 |
Protein |
denotes |
the PC |
T14328 |
1409-1414 |
Protein |
denotes |
TNF-α |
T14409 |
1409-1424 |
Positive_regulation |
denotes |
TNF-α signaling |
T14327 |
1492-1495 |
Protein |
denotes |
p65 |
T14398 |
1492-1520 |
Phosphorylation |
denotes |
p65 phosphorylation of NF-κB |
T14275 |
1512-1520 |
Protein |
denotes |
of NF-κB |
T14290 |
1565-1568 |
Protein |
denotes |
p65 |
T14412 |
1565-1584 |
Phosphorylation |
denotes |
p65 phosphorylation |
T14336 |
1602-1615 |
Entity |
denotes |
the cytoplasm |
T14297 |
1619-1635 |
Entity |
denotes |
the nucleus [30] |
T14292 |
1659-1669 |
Entity |
denotes |
p65-Thr435 |
T14361 |
1659-1669 |
Protein |
denotes |
p65-Thr435 |
T14386 |
1663-1669 |
Entity |
denotes |
Thr435 |
T14334 |
1703-1720 |
Entity |
denotes |
endothelial cells |
T14342 |
1844-1852 |
Entity |
denotes |
antigen, |
T14310 |
1856-1912 |
Protein |
denotes |
a protein expressed by endothelial cells of rat BBB [31] |
T14410 |
1856-1912 |
Gene_expression |
denotes |
a protein expressed by endothelial cells of rat BBB [31] |
T14266 |
1876-1912 |
Entity |
denotes |
by endothelial cells of rat BBB [31] |
T14330 |
1974-2005 |
Entity |
denotes |
endothelial cells [5,7,8,30,32] |
T14366 |
2195-2247 |
Entity |
denotes |
of intercellular junctions between endothelial cells |
T14358 |
2230-2247 |
Entity |
denotes |
endothelial cells |
T14370 |
2340-2356 |
Entity |
denotes |
endothelial cell |
T14298 |
2477-2479 |
Entity |
denotes |
SE |
T14329 |
2549-2566 |
Entity |
denotes |
sTNFp55R infusion |
T14284 |
2550-2553 |
Protein |
denotes |
TNF |
T14293 |
2589-2599 |
Entity |
denotes |
SE-induced |
T14395 |
2640-2688 |
Phosphorylation |
denotes |
the phosphorylation of p65-Thr435 by TNF-α [39], |
T14300 |
2660-2673 |
Protein |
denotes |
of p65-Thr435 |
T14371 |
2660-2673 |
Entity |
denotes |
of p65-Thr435 |
T14352 |
2674-2687 |
Protein |
denotes |
by TNF-α [39] |
T14268 |
2716-2730 |
Protein |
denotes |
TNF-α-mediated |
T14406 |
2716-2778 |
Regulation |
denotes |
TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells |
T14291 |
2731-2741 |
Protein |
denotes |
p65-Thr435 |
T14347 |
2731-2741 |
Entity |
denotes |
p65-Thr435 |
T14388 |
2761-2778 |
Entity |
denotes |
endothelial cells |
T14365 |
2956-2998 |
Protein |
denotes |
dystrophin (an actin-binding protein [40]) |
T14295 |
2968-2997 |
Protein |
denotes |
an actin-binding protein [40] |
T14279 |
3095-3116 |
Protein |
denotes |
down-regulated 12 hrs |
T14408 |
3095-3116 |
Negative_regulation |
denotes |
down-regulated 12 hrs |
T14355 |
3123-3125 |
Protein |
denotes |
SE |
T14269 |
3334-3351 |
Entity |
denotes |
endothelial cells |
T14379 |
3356-3379 |
Entity |
denotes |
perivascular astrocytes |
T14346 |
3403-3406 |
Protein |
denotes |
p65 |
T14307 |
3407-3413 |
Entity |
denotes |
Ser276 |
T14321 |
3415-3418 |
Protein |
denotes |
p65 |
T14294 |
3419-3425 |
Entity |
denotes |
Ser311 |
T14391 |
3427-3430 |
Protein |
denotes |
p65 |
T14377 |
3431-3437 |
Entity |
denotes |
Ser529 |
T14383 |
3443-3453 |
Entity |
denotes |
p65-Ser536 |
T14356 |
3443-3453 |
Protein |
denotes |
p65-Ser536 |
T14397 |
3443-3509 |
Phosphorylation |
denotes |
p65-Ser536 phosphorylation was observed in astrocytes following SE |
T14344 |
3486-3509 |
Entity |
denotes |
astrocytes following SE |
T14364 |
3507-3509 |
Protein |
denotes |
SE |
T14304 |
3524-3541 |
Entity |
denotes |
sTNFp55R infusion |
T14349 |
3525-3528 |
Protein |
denotes |
TNF |
T14267 |
3564-3574 |
Protein |
denotes |
p65-Ser276 |
T14384 |
3564-3574 |
Entity |
denotes |
p65-Ser276 |
T14351 |
3608-3618 |
Entity |
denotes |
astrocytes |
T14309 |
3629-3631 |
Protein |
denotes |
SE |
T14399 |
3662-3681 |
Positive_regulation |
denotes |
enhanced p65-Ser276 |
T14360 |
3662-3681 |
Protein |
denotes |
enhanced p65-Ser276 |
T14340 |
3662-3681 |
Entity |
denotes |
enhanced p65-Ser276 |
T14380 |
3686-3696 |
Protein |
denotes |
p65-Ser311 |
T14369 |
3686-3696 |
Entity |
denotes |
p65-Ser311 |
T14413 |
3686-3712 |
Phosphorylation |
denotes |
p65-Ser311 phosphorylation |
T14296 |
3732-3737 |
Protein |
denotes |
TNF-α |
T14353 |
3772-3789 |
Entity |
denotes |
sTNFp55R infusion |
T14390 |
3773-3776 |
Protein |
denotes |
TNF |
T14289 |
3808-3818 |
Entity |
denotes |
p65-Ser529 |
T14363 |
3808-3818 |
Protein |
denotes |
p65-Ser529 |
T14332 |
3823-3850 |
Entity |
denotes |
p65-Ser536 phosphorylations |
T14373 |
3823-3850 |
Protein |
denotes |
p65-Ser536 phosphorylations |
T14331 |
3856-3858 |
Entity |
denotes |
SE |
T14359 |
3874-3884 |
Protein |
denotes |
p65-Ser529 |
T14345 |
3874-3884 |
Entity |
denotes |
p65-Ser529 |
T14302 |
3889-3899 |
Entity |
denotes |
p65-Ser536 |
T14382 |
3889-3899 |
Protein |
denotes |
p65-Ser536 |
T14318 |
3922-3927 |
Protein |
denotes |
TNF-α |
T14324 |
3932-3943 |
Protein |
denotes |
IL-1β [41], |
T14272 |
3962-3976 |
Protein |
denotes |
IL-1β-mediated |
T14357 |
4035-4045 |
Entity |
denotes |
SE-induced |
T14322 |
4106-4111 |
Protein |
denotes |
TNF-α |
T14281 |
4116-4121 |
Protein |
denotes |
IL-1β |
T14372 |
4129-4147 |
Entity |
denotes |
synergists to play |
T14316 |
4168-4185 |
Entity |
denotes |
endothelial cells |
T14306 |
4203-4213 |
Entity |
denotes |
astrocytes |
T14323 |
4260-4270 |
Entity |
denotes |
Neutrophil |
T14271 |
4353-4358 |
Protein |
denotes |
of SE |
T14333 |
4376-4378 |
Entity |
denotes |
SE |
T14311 |
4412-4414 |
Entity |
denotes |
SE |
T14288 |
4458-4468 |
Protein |
denotes |
chemokines |
T14313 |
4524-4529 |
Protein |
denotes |
MIP-2 |
T14264 |
4546-4566 |
Entity |
denotes |
efficient neutrophil |
T14282 |
4570-4580 |
Entity |
denotes |
lymphocyte |
T14411 |
4570-4617 |
Binding |
denotes |
lymphocyte recruitment to brain parenchyma [43] |
T14262 |
4647-4657 |
Entity |
denotes |
neutrophil |
T14404 |
4714-4756 |
Gene_expression |
denotes |
by P2X7 receptor-mediated MIP-2 expression |
T14401 |
4714-4756 |
Regulation |
denotes |
by P2X7 receptor-mediated MIP-2 expression |
T14317 |
4717-4721 |
Protein |
denotes |
P2X7 |
T14285 |
4722-4739 |
Protein |
denotes |
receptor-mediated |
T14270 |
4740-4745 |
Protein |
denotes |
MIP-2 |
T14343 |
4761-4768 |
Protein |
denotes |
the PC, |
T14394 |
4802-4820 |
Entity |
denotes |
agonist/antagonist |
T14348 |
4802-4820 |
Entity |
denotes |
agonist/antagonist |
T14341 |
4810-4820 |
Entity |
denotes |
antagonist |
T14362 |
4825-4853 |
Protein |
denotes |
IL-1Ra (an IL-1β antagonist) |
T14393 |
4825-4862 |
Entity |
denotes |
IL-1Ra (an IL-1β antagonist) infusion |
T14319 |
4833-4852 |
Protein |
denotes |
an IL-1β antagonist |
T14392 |
4880-4889 |
Entity |
denotes |
leukocyte |
T14326 |
4927-4934 |
Entity |
denotes |
TNFp55R |
T14367 |
4927-4934 |
Protein |
denotes |
TNFp55R |
T14260 |
4935-4943 |
Entity |
denotes |
infusion |
T14283 |
4966-4976 |
Entity |
denotes |
neutrophil |
T14274 |
4993-4999 |
Protein |
denotes |
the PC |
T14407 |
5003-5067 |
Negative_regulation |
denotes |
reducing vasogenic edema formation in a MIP-2-independent manner |
T14339 |
5043-5060 |
Protein |
denotes |
MIP-2-independent |
T14338 |
5175-5183 |
Protein |
denotes |
by TNF-α |
T14286 |
5195-5205 |
Entity |
denotes |
neutrophil |
T14387 |
5273-5280 |
Protein |
denotes |
the PC, |
T14308 |
5364-5380 |
Entity |
denotes |
endothelial cell |
T14320 |
5394-5408 |
Protein |
denotes |
TNF-α mediated |
T14414 |
5394-5408 |
Regulation |
denotes |
TNF-α mediated |
T14265 |
5394-5442 |
Protein |
denotes |
TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
T14259 |
5394-5442 |
Entity |
denotes |
TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
T14396 |
5394-5442 |
Phosphorylation |
denotes |
TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
T14305 |
5421-5426 |
Protein |
denotes |
NF-κB |
T14385 |
5462-5464 |
Entity |
denotes |
SE |
T14277 |
5511-5521 |
Entity |
denotes |
neutrophil |
R11186 |
T14259 |
T14305 |
partOf |
TNF-α mediated p65-Thr 435 NF-κB phosphorylation,NF-κB |
R11187 |
T14259 |
T14396 |
siteOf |
TNF-α mediated p65-Thr 435 NF-κB phosphorylation,TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
R11189 |
T14268 |
T14406 |
causeOf |
TNF-α-mediated,TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells |
R11192 |
T14270 |
T14404 |
themeOf |
MIP-2,by P2X7 receptor-mediated MIP-2 expression |
R11195 |
T14275 |
T14398 |
themeOf |
of NF-κB,p65 phosphorylation of NF-κB |
R11196 |
T14279 |
T14408 |
themeOf |
down-regulated 12 hrs,down-regulated 12 hrs |
R11197 |
T14285 |
T14401 |
causeOf |
receptor-mediated,by P2X7 receptor-mediated MIP-2 expression |
R11198 |
T14287 |
T14400 |
causeOf |
TNF-α,of TNF-α signaling |
R11199 |
T14290 |
T14412 |
themeOf |
p65,p65 phosphorylation |
R11200 |
T14380 |
T14413 |
themeOf |
p65-Ser311,p65-Ser311 phosphorylation |
R11201 |
T14383 |
T14356 |
partOf |
p65-Ser536,p65-Ser536 |
R11202 |
T14383 |
T14397 |
siteOf |
p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE |
R11203 |
T14300 |
T14395 |
themeOf |
of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39]," |
R11204 |
T14305 |
T14396 |
themeOf |
NF-κB,TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
R11205 |
T14310 |
T14410 |
themeOf |
a protein expressed by endothelial cells of rat BBB [31],a protein expressed by endothelial cells of rat BBB [31] |
R11206 |
T14404 |
T14401 |
themeOf |
by P2X7 receptor-mediated MIP-2 expression,by P2X7 receptor-mediated MIP-2 expression |
R11207 |
T14314 |
T14405 |
causeOf |
TNF-α,TNF-α signaling |
R11208 |
T14320 |
T14396 |
causeOf |
TNF-α mediated,TNF-α mediated p65-Thr 435 NF-κB phosphorylation |
R11209 |
T14320 |
T14414 |
themeOf |
TNF-α mediated,TNF-α mediated |
R11210 |
T14327 |
T14398 |
causeOf |
p65,p65 phosphorylation of NF-κB |
R11211 |
T14328 |
T14409 |
causeOf |
TNF-α,TNF-α signaling |
R11212 |
T14352 |
T14395 |
causeOf |
by TNF-α [39],"the phosphorylation of p65-Thr435 by TNF-α [39]," |
R11213 |
T14356 |
T14397 |
themeOf |
p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE |
R11214 |
T14360 |
T14399 |
themeOf |
enhanced p65-Ser276,enhanced p65-Ser276 |
R11215 |
T14368 |
T14402 |
causeOf |
TNF-α,TNF-α signaling |
R11216 |
T14369 |
T14380 |
partOf |
p65-Ser311,p65-Ser311 |
R11217 |
T14369 |
T14413 |
siteOf |
p65-Ser311,p65-Ser311 phosphorylation |
R11218 |
T14371 |
T14300 |
partOf |
of p65-Thr435,of p65-Thr435 |
R11219 |
T14371 |
T14395 |
siteOf |
of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39]," |
R11220 |
T14374 |
T14403 |
themeOf |
NF-κB,NF-κB phosphorylation |