bionlp-st-ge-2016-test-ihmc  

PMC:3312845 / 1819-34551 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2887 31-33 Entity denotes SE
T2859 90-92 Protein denotes SE
T2903 256-258 Protein denotes SE
T2890 382-384 Protein denotes PC
T2886 473-484 Entity denotes pilocarpine
T2884 541-576 Entity denotes Pilocarpine, a cholinergic agonist,
T2929 554-575 Entity denotes a cholinergic agonist
T2866 585-587 Entity denotes SE
T2904 600-650 Protein denotes This pilocarpine-induced SE, similar to human TLE,
T2905 605-624 Entity denotes pilocarpine-induced
T2878 759-770 Entity denotes pilocarpine
T2860 880-899 Entity denotes pilocarpine-induced
T2922 880-902 Entity denotes pilocarpine-induced SE
T2889 944-953 Entity denotes layers II
T2862 965-977 Protein denotes the PC [5,6]
T2925 979-981 Entity denotes SE
T2867 1021-1080 Protein denotes the PC accompanied by neuronal and astroglial damages [5-8]
T2893 1124-1133 Entity denotes cytotoxic
T2869 1184-1207 Entity denotes cytotoxic osmotic edema
T2930 1270-1273 Protein denotes SE,
T2910 1290-1303 Entity denotes intracellular
T2864 1290-1307 Entity denotes intracellular Na+
T2915 1312-1316 Entity denotes Ca2+
T2885 1381-1398 Entity denotes endothelial cells
T2865 2283-2306 Entity denotes of various interleukins
T2913 2381-2390 Protein denotes Cytokines
T2896 2398-2415 Entity denotes endothelial cells
T2882 2572-2585 Entity denotes dexamethasone
T2902 2645-2664 Entity denotes kainic acid-induced
T2880 2680-2689 Protein denotes cytokines
T2917 2691-2722 Protein denotes tumor necrosis factor-α (TNF-α)
T2900 2716-2721 Protein denotes TNF-α
T2926 2726-2824 Entity denotes a 17 kDa protein that is produced mainly by activated macrophages and T cells in the immune system
T2919 2726-2824 Protein denotes a 17 kDa protein that is produced mainly by activated macrophages and T cells in the immune system
T2870 2770-2791 Entity denotes activated macrophages
T2877 2796-2824 Entity denotes T cells in the immune system
T2879 2826-2831 Protein denotes TNF-α
T2868 2911-2918 Entity denotes neurons
T2906 2923-2940 Entity denotes endothelial cells
T2916 2993-2995 Entity denotes SE
T2909 3005-3010 Protein denotes TNF-α
T2892 3105-3120 Entity denotes of target cells
T2895 3150-3158 Protein denotes receptor
T2899 3168-3183 Protein denotes TNF receptor I,
T2894 3187-3190 Protein denotes p55
T2901 3187-3199 Protein denotes p55 receptor
T2920 3201-3208 Protein denotes TNFp55R
T2897 3215-3231 Protein denotes TNF receptor II,
T2883 3235-3257 Protein denotes p75 receptor (TNFp75R)
T2907 3249-3256 Protein denotes TNFp75R
T2874 3277-3282 Protein denotes TNF-α
T2935 3277-3332 Positive_regulation denotes TNF-α induces macrophage inflammatory protein-2 (MIP-2)
T2934 3277-3332 Gene_expression denotes TNF-α induces macrophage inflammatory protein-2 (MIP-2)
T2912 3291-3332 Protein denotes macrophage inflammatory protein-2 (MIP-2)
T2921 3326-3331 Protein denotes MIP-2
T2931 3338-3410 Binding denotes recruits neutrophils under pathological conditions, including SE [14,20]
T2928 3347-3358 Entity denotes neutrophils
T2914 3400-3410 Protein denotes SE [14,20]
T2888 3412-3419 Entity denotes Neurons
T2932 3412-3521 Gene_expression denotes Neurons, microglia, and astrocytes produce MIP-2 when incubated with pro-inflammatory cytokines such as TNF-α
T2871 3421-3430 Entity denotes microglia
T2875 3436-3446 Entity denotes astrocytes
T2918 3455-3460 Protein denotes MIP-2
T2881 3481-3515 Protein denotes pro-inflammatory cytokines such as
T2923 3481-3521 Protein denotes pro-inflammatory cytokines such as TNF-α
T2863 3529-3551 Protein denotes interleukin-1β (IL-1β)
T2924 3545-3550 Protein denotes IL-1β
T2908 3616-3618 Entity denotes SE
T2936 3619-3644 Gene_expression denotes mediated MIP-2 expression
T2933 3619-3644 Regulation denotes mediated MIP-2 expression
T2861 3628-3633 Protein denotes MIP-2
T2873 3660-3669 Entity denotes leukocyte
T2911 3694-3696 Protein denotes SE
T2927 3703-3720 Protein denotes IL-1β-independent
T2872 3772-3777 Protein denotes TNF-α
T2891 3983-3991 Protein denotes of TNF-α
T2876 4066-4091 Protein denotes by pilocarpine-induced SE
T2898 4069-4088 Entity denotes pilocarpine-induced
T3927 4896-4933 Entity denotes Intracerebroventricular drug infusion
T3924 4896-4933 Entity denotes Intracerebroventricular drug infusion
T3917 4944-5021 Protein denotes divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
T3934 4944-5021 Regulation denotes divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
T3930 4978-4984 Entity denotes saline
T3921 5024-5027 Protein denotes TNF
T3920 5043-5075 Protein denotes Sigma-Aldrich Co., St. Louis, MO
T3919 5093-5110 Protein denotes The dosage of sTN
T3922 5164-5251 Protein denotes SE of comparable severity in 100% of animals with 5% mortality in the preliminary study
T3932 5456-5478 Entity denotes a brain infusion kit 1
T3928 5595-5628 Entity denotes position with bregma as reference
T3926 5682-5698 Entity denotes The infusion kit
T3925 5933-5953 Entity denotes the dose of sTNFp55R
T3933 5946-5949 Protein denotes TNF
T3929 6108-6110 Entity denotes SE
T3931 6234-6242 Protein denotes of TNF-α
T3918 6248-6266 Protein denotes 3 days prior to SE
T3923 6270-6327 Entity denotes 4 days after SE when the volume of vasogenic edema peaked
T4406 6397-6420 Entity denotes pilocarpine (380 mg/kg,
T4403 6421-6445 Protein denotes i.p.; Sigma-Aldrich Co.,
T4399 6505-6529 Protein denotes i.p.; Sigma-Aldrich Co.,
T4396 6631-6671 Entity denotes Approximately 80% of pilocarpine treated
T4397 6649-6671 Entity denotes of pilocarpine treated
T4402 6713-6715 Entity denotes SE
T4398 7043-7062 Entity denotes pilocarpine-induced
T4404 7083-7102 Entity denotes Diazepam (10 mg/kg,
T4401 7083-7107 Protein denotes Diazepam (10 mg/kg, i.p.
T4408 7183-7188 Protein denotes of SE
T4400 7353-7364 Protein denotes SE (non-SE)
T4405 7423-7431 Entity denotes min, n =
T4407 7486-7489 Entity denotes n =
T4737 7540-7604 Protein denotes non-SE: 12 hr, 1 day, 2 days, 3 days, 4 days and 1 week after SE
T4733 7606-7609 Entity denotes n =
T4732 7677-7695 Entity denotes phosphate-buffered
T4734 7677-7708 Entity denotes phosphate-buffered saline (PBS)
T4739 7718-7740 Entity denotes by 4% paraformaldehyde
T4735 7750-7759 Entity denotes phosphate
T4729 7768-7770 Protein denotes PB
T4736 7786-7805 Entity denotes urethane anesthesia
T4738 7823-7852 Protein denotes Sigma-Aldrich Co., St. Louis,
T4730 7900-7926 Entity denotes the same fixative for 4 hr
T4731 7986-8007 Entity denotes 30% sucrose overnight
T5358 8441-8460 Protein denotes rabbit anti-MPO IgG
T5356 8572-8609 Entity denotes 0.3% Triton X-100 (Sigma-Aldrich Co.,
T5363 8591-8608 Protein denotes Sigma-Aldrich Co.
T5349 8650-8667 Protein denotes Sigma-Aldrich Co.
T5355 8877-8909 Entity denotes ABC complex (Vector, Burlingame,
T5352 8932-8949 Entity denotes the same solution
T5360 9129-9143 Protein denotes serum-proteins
T5350 9197-9215 Protein denotes a primary antibody
T5359 9251-9278 Entity denotes 3,3'-diaminobenzidine (DAB,
T5353 9251-9296 Protein denotes 3,3'-diaminobenzidine (DAB, Sigma-Aldrich Co.
T5362 9316-9326 Entity denotes 0.1 M Tris
T5351 9552-9564 Protein denotes the antibody
T5354 9600-9616 Entity denotes purified peptide
T5357 9692-9712 Entity denotes the primary antibody
T5361 9793-9809 Entity denotes primary antibody
T5840 9873-9910 Protein denotes 3% bovine serum albumin in PBS for 30
T5845 10855-10873 Entity denotes a mixture of FITC-
T5844 10868-10873 Entity denotes FITC-
T5841 11088-11110 Entity denotes nuclei counterstaining
T5843 11153-11157 Entity denotes DAPI
T5839 11228-11230 Entity denotes M2
T5842 11246-11260 Protein denotes AxioVision Rel
T6352 11277-11290 Entity denotes Fluoro-Jade B
T6350 11300-11319 Entity denotes Fluoro-Jade B (FJB)
T6361 11363-11418 Binding denotes neurons in tissues obtained from non-SE and 3 days post
T6349 11363-11418 Entity denotes neurons in tissues obtained from non-SE and 3 days post
T6360 11545-11547 Entity denotes SE
T6345 11587-11589 Protein denotes SE
T6359 11777-11789 Entity denotes 100% ethanol
T6357 11810-11830 Entity denotes by 70% ethanol for 2
T6358 11902-11937 Entity denotes 0.06% potassium permanganate for 15
T6351 12087-12089 Protein denotes AR
T6355 12142-12185 Entity denotes FJB solution to 180 ml of 0.1% acetic acid,
T6354 12158-12185 Entity denotes 180 ml of 0.1% acetic acid,
T6353 12165-12184 Entity denotes of 0.1% acetic acid
T6346 12325-12331 Entity denotes xylene
T6356 12354-12377 Protein denotes DPX (Sigma-Aldrich Co.,
T6348 12359-12376 Protein denotes Sigma-Aldrich Co.
T6347 12464-12477 Protein denotes the entire PC
T7146 12525-12529 Entity denotes cell
T7140 12611-12613 Protein denotes PC
T7134 12782-12799 Protein denotes by AxioVision Rel
T7151 12883-12886 Protein denotes ssf
T7133 13086-13089 Protein denotes mm3
T7142 13136-13148 Entity denotes cell numbers
T7137 13539-13544 Entity denotes h; 15
T7139 13589-13610 Entity denotes of each cell type (C)
T7132 13664-13665 Entity denotes t
T7136 13666-13667 Entity denotes h
T7141 13680-13683 Protein denotes ssf
T7144 13708-13716 Entity denotes of cells
T7148 13843-13846 Protein denotes Asf
T7150 14081-14086 Protein denotes asf =
T7135 14113-14137 Entity denotes The immunoreactive cells
T7149 14178-14202 Entity denotes The immunoreactive cells
T7145 14243-14267 Entity denotes All immunoreactive cells
T7147 14319-14323 Entity denotes Cell
T7138 14426-14436 Entity denotes SE-induced
T7131 14426-14447 Protein denotes SE-induced PC atrophy
T7143 14536-14545 Protein denotes of the PC
T7130 14575-14583 Entity denotes of cells
T7645 14973-14987 Protein denotes AxioVision Rel
T7644 15091-15097 Protein denotes the PC
T7647 15160-15197 Protein denotes the PC (15 sections from each animal)
T7643 15309-15346 Entity denotes n = 36 per region examined, in non-SE
T7648 15575-15675 Negative_regulation denotes Manipulation of the images was restricted to threshold and brightness adjustments to the whole image
T7646 15784-15798 Protein denotes AxioVision Rel
T7776 16069-16073 Entity denotes cell
T7775 16315-16321 Protein denotes of MPO
T8296 16361-16367 Protein denotes TNF-α,
T8277 16361-16384 Protein denotes TNF-α, and TNF receptor
T8304 16361-16395 Gene_expression denotes TNF-α, and TNF receptor expression
T8297 16372-16375 Protein denotes TNF
T8302 16452-16457 Protein denotes TNF-α
T8290 16498-16500 Protein denotes PC
T8288 16498-16525 Entity denotes PC neurons (data not shown)
T8281 16541-16543 Protein denotes SE
T8295 16581-16612 Entity denotes most of the activated microglia
T8301 16586-16612 Entity denotes of the activated microglia
T8286 16627-16632 Protein denotes TNF-α
T8282 16691-16723 Protein denotes maintained up to 1 week after SE
T8293 16728-16734 Entity denotes non-SE
T8283 16781-16788 Protein denotes TNFp55R
T8280 16793-16800 Protein denotes TNFp75R
T8303 16849-16876 Entity denotes astrocytes (data not shown)
T8300 16892-16894 Protein denotes SE
T8278 16932-16939 Protein denotes TNFp55R
T8287 16973-16995 Entity denotes astrocytes (Figure 1B)
T8299 17004-17012 Protein denotes TNFp55R,
T8292 17013-17020 Protein denotes TNFp75R
T8285 17054-17071 Entity denotes endothelial cells
T8279 17083-17093 Entity denotes astrocytes
T8284 17134-17137 Protein denotes SE,
T8298 17143-17150 Protein denotes TNFp55R
T8289 17155-17162 Protein denotes TNFp75R
T8291 17212-17223 Entity denotes astrocytes,
T8294 17231-17249 Entity denotes endothelial cells,
T14686 17320-17377 Gene_expression denotes Expression of TNF-α and TNF receptor in the PC 12 hr-post
T14685 17320-17377 Gene_expression denotes Expression of TNF-α and TNF receptor in the PC 12 hr-post
T14674 17334-17339 Protein denotes TNF-α
T14681 17344-17347 Protein denotes TNF
T14671 17344-17356 Protein denotes TNF receptor
T14679 17364-17366 Protein denotes PC
T14672 17378-17380 Protein denotes SE
T14676 17386-17391 Protein denotes TNF-α
T14673 17409-17445 Entity denotes in Ox-42-positive microglia (arrows)
T14682 17451-17458 Protein denotes TNFp55R
T14684 17451-17492 Gene_expression denotes TNFp55R expression in astrocytes (arrows)
T14680 17473-17492 Entity denotes astrocytes (arrows)
T14675 17500-17507 Protein denotes TNFp75R
T14683 17500-17570 Gene_expression denotes TNFp75R expression in astrocytes as well as endothelial cells (arrows)
T14670 17522-17532 Entity denotes astrocytes
T14677 17544-17570 Entity denotes endothelial cells (arrows)
T14678 17572-17577 Entity denotes Bar =
T8583 17599-17619 Entity denotes of sTNFp55R infusion
T8588 17603-17606 Protein denotes TNF
T8582 17623-17633 Entity denotes SE-induced
T8571 17623-17661 Entity denotes SE-induced serum-protein extravasation
T8570 17623-17661 Protein denotes SE-induced serum-protein extravasation
T8574 17796-17812 Protein denotes 3 days after SE,
T8587 17870-17872 Entity denotes SE
T8589 17920-17940 Entity denotes of sTNFp55R infusion
T8576 17924-17927 Protein denotes TNF
T8569 17994-17999 Entity denotes by SE
T8578 18004-18018 Entity denotes saline-treated
T8581 18028-18034 Protein denotes the PC
T8579 18133-18148 Protein denotes mm3 (Figure 2E)
T8575 18161-18184 Entity denotes of FJB-positive neurons
T8568 18188-18194 Protein denotes the PC
T8580 18233-18236 Protein denotes TNF
T8577 18258-18268 Entity denotes SE-induced
T8585 18313-18336 Protein denotes mm3 (Figures 2C and 2E)
T8586 18362-18385 Entity denotes of FJB-positive neurons
T8584 18389-18395 Protein denotes the PC
T8573 18437-18454 Entity denotes sTNFp55R infusion
T8572 18438-18441 Protein denotes TNF
T8567 18466-18476 Entity denotes SE-induced
T14928 18577-18597 Entity denotes of sTNFp55R infusion
T14933 18581-18584 Protein denotes TNF
T14940 18601-18611 Entity denotes SE-induced
T14932 18601-18639 Entity denotes SE-induced serum-protein extravasation
T14927 18601-18639 Protein denotes SE-induced serum-protein extravasation
T14941 18667-18680 Protein denotes Serum-protein
T14942 18667-18694 Entity denotes Serum-protein extravasation
T14935 18732-18754 Protein denotes the PC 3 days after SE
T14938 18752-18754 Protein denotes SE
T14930 18792-18819 Protein denotes serum-protein extravasation
T14937 18906-18912 Entity denotes Bars =
T14936 18977-19004 Protein denotes serum-protein extravasation
T14931 18977-19004 Entity denotes serum-protein extravasation
T14939 19041-19054 Protein denotes the PC 3 days
T14929 19061-19078 Entity denotes SE (mean ± S.E.M)
T14934 19109-19115 Entity denotes saline
T9306 19145-19150 Protein denotes NF-κB
T9342 19145-19166 Phosphorylation denotes NF-κB phosphorylation
T9303 19195-19200 Protein denotes TNF-α
T9339 19236-19260 Phosphorylation denotes phosphorylation of NF-κB
T9331 19252-19260 Protein denotes of NF-κB
T9312 19273-19287 Protein denotes TNF-α-mediated
T9305 19273-19311 Entity denotes TNF-α-mediated signaling following SE,
T9335 19360-19389 Entity denotes five phospho-NF-κB antibodies
T9300 19373-19378 Protein denotes NF-κB
T9322 19447-19449 Protein denotes SE
T9333 19461-19471 Entity denotes the saline
T9301 19493-19503 Entity denotes p65-Ser276
T9292 19493-19503 Protein denotes p65-Ser276
T9315 19505-19515 Protein denotes p65-Ser311
T9308 19505-19515 Entity denotes p65-Ser311
T9320 19517-19527 Entity denotes p65-Ser529
T9295 19517-19527 Protein denotes p65-Ser529
T9327 19533-19543 Protein denotes p65-Ser536
T9314 19533-19543 Entity denotes p65-Ser536
T9340 19533-19559 Phosphorylation denotes p65-Ser536 phosphorylation
T9325 19563-19573 Entity denotes astrocytes
T9330 19579-19596 Entity denotes endothelial cells
T9334 19599-19616 Entity denotes sTNFp55R infusion
T9302 19600-19603 Protein denotes TNF
T9309 19637-19647 Entity denotes p65-Ser276
T9299 19637-19647 Protein denotes p65-Ser276
T9307 19652-19662 Protein denotes p65-Ser311
T9296 19652-19662 Entity denotes p65-Ser311
T9338 19652-19678 Phosphorylation denotes p65-Ser311 phosphorylation
T9326 19680-19681 Entity denotes p
T9332 19731-19741 Protein denotes p65-Ser529
T9311 19731-19741 Entity denotes p65-Ser529
T9323 19745-19755 Entity denotes p65-Ser536
T9313 19745-19755 Protein denotes p65-Ser536
T9341 19745-19771 Phosphorylation denotes p65-Ser536 phosphorylation
T9336 19792-19866 Positive_regulation denotes In contrast, p65-Thr435 phosphorylation was increased in endothelial cells
T9321 19805-19815 Entity denotes p65-Thr435
T9298 19805-19815 Protein denotes p65-Thr435
T9337 19805-19831 Phosphorylation denotes p65-Thr435 phosphorylation
T9293 19849-19866 Entity denotes endothelial cells
T9324 19872-19882 Entity denotes astrocytes
T9297 19891-19923 Protein denotes the PC of saline-infused animals
T9317 19936-19950 Protein denotes SE (Figure 5A)
T9329 19966-19969 Protein denotes TNF
T9316 19966-19982 Entity denotes TNFp55R infusion
T9294 20006-20016 Entity denotes SE-induced
T9318 20006-20027 Entity denotes SE-induced p65-Thr435
T9291 20006-20027 Protein denotes SE-induced p65-Thr435
T9319 20047-20065 Entity denotes endothelial cells,
T9328 20075-20084 Entity denotes to saline
T9304 20085-20093 Entity denotes infusion
T9310 20095-20096 Entity denotes p
T15416 20134-20154 Entity denotes of sTNFp55R infusion
T15417 20138-20141 Protein denotes TNF
T15434 20155-20193 Phosphorylation denotes on NF-κB phosphorylation in astrocytes
T15423 20158-20163 Protein denotes NF-κB
T15424 20183-20193 Entity denotes astrocytes
T15430 20206-20208 Entity denotes SE
T15413 20224-20226 Protein denotes SE
T15431 20280-20290 Entity denotes astrocytes
T15411 20296-20306 Entity denotes p65-Ser276
T15402 20296-20306 Protein denotes p65-Ser276
T15404 20312-20326 Entity denotes p65-Ser311 (C)
T15401 20312-20326 Protein denotes p65-Ser311 (C)
T15419 20328-20342 Entity denotes p65-Ser529 (E)
T15406 20328-20342 Protein denotes p65-Ser529 (E)
T15426 20348-20362 Entity denotes p65-Ser536 (G)
T15421 20348-20362 Protein denotes p65-Ser536 (G)
T15435 20348-20378 Phosphorylation denotes p65-Ser536 (G) phosphorylation
T15420 20389-20397 Protein denotes sTNFp55R
T15415 20389-20397 Entity denotes sTNFp55R
T15425 20398-20422 Entity denotes infusion (B, D, F and H)
T15407 20420-20421 Entity denotes H
T15428 20443-20457 Protein denotes p65-Ser276 (B)
T15418 20443-20457 Entity denotes p65-Ser276 (B)
T15427 20447-20453 Entity denotes Ser276
T15410 20462-20476 Entity denotes p65-Ser311 (D)
T15408 20462-20476 Protein denotes p65-Ser311 (D)
T15409 20466-20472 Entity denotes Ser311
T15422 20519-20533 Entity denotes p65-Ser529 (F)
T15403 20519-20533 Protein denotes p65-Ser529 (F)
T15429 20531-20532 Entity denotes F
T15432 20538-20552 Entity denotes p65-Ser536 (H)
T15414 20538-20552 Protein denotes p65-Ser536 (H)
T15433 20538-20568 Phosphorylation denotes p65-Ser536 (H) phosphorylation
T15412 20550-20551 Entity denotes H
T15405 20579-20592 Protein denotes Bar = 12.5 μm
T15685 20640-20660 Entity denotes of sTNFp55R infusion
T15680 20644-20647 Protein denotes TNF
T15682 20664-20669 Protein denotes NF-κB
T15693 20664-20685 Phosphorylation denotes NF-κB phosphorylation
T15694 20735-20789 Phosphorylation denotes of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M)
T15689 20738-20743 Protein denotes NF-κB
T15684 20772-20789 Entity denotes SE (mean ± S.E.M)
T15686 20820-20826 Entity denotes saline
T15690 20859-20916 Protein denotes Quantitative analysis of SMI-71 expression 1 day after SE
T15687 20962-20968 Entity denotes saline
T15683 21036-21046 Entity denotes p65-Thr435
T15681 21036-21046 Protein denotes p65-Thr435
T15692 21036-21062 Phosphorylation denotes p65-Thr435 phosphorylation
T15688 21077-21096 Protein denotes the PC following SE
T15691 21094-21096 Entity denotes SE
T16211 21108-21186 Protein denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16204 21108-21186 Entity denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16198 21108-21186 Protein denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16208 21143-21149 Entity denotes Thr435
T16181 21169-21186 Entity denotes endothelial cells
T16178 21197-21199 Protein denotes SE
T16218 21218-21247 Phosphorylation denotes of p65-Thr435 phosphorylation
T16189 21221-21231 Protein denotes p65-Thr435
T16182 21221-21231 Entity denotes p65-Thr435
T16193 21248-21268 Entity denotes by sTNFp55R infusion
T16200 21252-21255 Protein denotes TNF
T16191 21281-21283 Entity denotes SE
T16212 21285-21295 Entity denotes p65-Thr435
T16197 21285-21295 Protein denotes p65-Thr435
T16217 21285-21353 Phosphorylation denotes p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
T16180 21334-21353 Entity denotes astrocytes (arrows)
T16215 21359-21415 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in non-SE animals
T16206 21359-21415 Protein denotes Endothelial p65-Thr435 phosphorylation in non-SE animals
T16207 21375-21381 Entity denotes Thr435
T16205 21418-21421 Entity denotes D-E
T16219 21423-21502 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
T16202 21435-21445 Protein denotes p65-Thr435
T16184 21435-21445 Entity denotes p65-Thr435
T16183 21465-21502 Protein denotes saline-infused animals 1 day after SE
T16199 21504-21514 Protein denotes p65-Thr435
T16196 21504-21514 Entity denotes p65-Thr435
T16216 21504-21530 Phosphorylation denotes p65-Thr435 phosphorylation
T16213 21504-21542 Positive_regulation denotes p65-Thr435 phosphorylation is enhanced
T16220 21544-21624 Negative_regulation denotes while SMI-71 expression is reduced in GLUT-1-positive endothelial cells (arrows)
T16190 21582-21588 Protein denotes GLUT-1
T16210 21589-21615 Entity denotes positive endothelial cells
T16214 21632-21712 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
T16201 21644-21654 Entity denotes p65-Thr435
T16194 21644-21654 Protein denotes p65-Thr435
T16195 21674-21712 Entity denotes sTNFp55R-infused animal 1 day after SE
T16188 21715-21722 Protein denotes TNFp55R
T16185 21715-21722 Entity denotes TNFp55R
T16192 21723-21731 Entity denotes infusion
T16209 21752-21762 Protein denotes p65-Thr435
T16179 21752-21762 Entity denotes p65-Thr435
T16186 21798-21804 Protein denotes GLUT-1
T16203 21805-21831 Entity denotes positive endothelial cells
T16187 21868-21871 Entity denotes E-G
T9852 21956-21963 Entity denotes antigen
T9840 21995-22007 Protein denotes the PC 1 day
T9847 22014-22020 Protein denotes SE [5]
T9836 22047-22049 Protein denotes SE
T9849 22145-22147 Protein denotes IV
T9845 22151-22157 Protein denotes the PC
T9841 22311-22313 Entity denotes SE
T9854 22359-22410 Phosphorylation denotes increased p65-Thr435 phosphorylation (Figures 5C-D)
T9853 22359-22410 Positive_regulation denotes increased p65-Thr435 phosphorylation (Figures 5C-D)
T9848 22369-22379 Protein denotes p65-Thr435
T9843 22369-22379 Entity denotes p65-Thr435
T9855 22461-22567 Phosphorylation denotes was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
T9839 22489-22499 Protein denotes p65-Thr435
T9835 22489-22499 Entity denotes p65-Thr435
T9838 22569-22570 Entity denotes p
T9844 22604-22621 Entity denotes sTNFp55R infusion
T9846 22605-22608 Protein denotes TNF
T9851 22645-22655 Protein denotes p65-Thr435
T9850 22645-22655 Entity denotes p65-Thr435
T9842 22713-22730 Entity denotes endothelial cells
T9837 22741-22743 Protein denotes SE
T9834 22760-22811 Entity denotes saline infusion (p < 0.05; Figures 4A-B, 5D and 5F)
T10341 22814-22824 Entity denotes Neutrophil
T10346 22872-22883 Entity denotes neutrophils
T10342 22982-22992 Entity denotes neutrophil
T10356 23019-23021 Protein denotes IV
T10350 23025-23051 Protein denotes the PC 1 day after SE [20]
T10362 23044-23051 Entity denotes SE [20]
T10351 23100-23110 Entity denotes the saline
T10358 23148-23151 Protein denotes MPO
T10344 23152-23172 Entity denotes positive neutrophils
T10355 23178-23184 Protein denotes the PC
T10357 23256-23266 Entity denotes neutrophil
T10361 23285-23318 Protein denotes the PC 1 day after SE (Figure 6A)
T10352 23304-23306 Entity denotes SE
T10347 23358-23360 Protein denotes PC
T10360 23445-23453 Entity denotes sTNFp55R
T10348 23445-23453 Protein denotes sTNFp55R
T10343 23591-23601 Entity denotes neutrophil
T10359 23722-23732 Entity denotes neutrophil
T10345 23917-23927 Entity denotes SE-induced
T10349 23928-23938 Entity denotes neutrophil
T10354 23957-23963 Protein denotes the PC
T10363 23982-24025 Regulation denotes to TNF-α-mediated vasogenic edema formation
T10353 23985-23999 Protein denotes TNF-α-mediated
T16809 24048-24051 Protein denotes TNF
T16797 24048-24125 Entity denotes TNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE
T16814 24068-24078 Entity denotes neutrophil
T16800 24096-24101 Protein denotes MIP-2
T16816 24096-24112 Gene_expression denotes MIP-2 expression
T16793 24123-24125 Protein denotes SE
T16802 24131-24141 Entity denotes Neutrophil
T16804 24193-24195 Entity denotes SE
T16807 24201-24206 Protein denotes MIP-2
T16815 24201-24242 Gene_expression denotes MIP-2 expression in the PC 1 day after SE
T16799 24221-24233 Protein denotes the PC 1 day
T16803 24240-24242 Protein denotes SE
T16805 24248-24287 Protein denotes Astroglial expression of MIP-2 (arrows)
T16796 24356-24366 Entity denotes neutrophil
T16791 24392-24394 Entity denotes SE
T16806 24440-24446 Entity denotes saline
T16792 24514-24551 Entity denotes the number of infiltrated neutrophils
T16798 24622-24628 Protein denotes the PC
T16795 24670-24693 Entity denotes of MIP-2 positive cells
T16811 24673-24678 Protein denotes MIP-2
T16810 24743-24760 Entity denotes SE (mean ± S.E.M)
T16794 24802-24807 Protein denotes MIP-2
T16801 24808-24822 Entity denotes positive cells
T16808 24967-24990 Entity denotes of MIP-2 positive cells
T16813 24970-24975 Protein denotes MIP-2
T16812 25066-25072 Protein denotes the PC
T11256 25075-25080 Protein denotes MIP-2
T11273 25075-25091 Gene_expression denotes MIP-2 expression
T11241 25092-25097 Protein denotes MIP-2
T11260 25101-25173 Protein denotes a powerful chemokine that contributes to recruitment of neutrophils [27]
T11264 25157-25173 Entity denotes neutrophils [27]
T11246 25175-25180 Protein denotes MIP-2
T11268 25318-25323 Protein denotes TNF-α
T11247 25331-25353 Protein denotes interleukin-1β (IL-1β)
T11263 25347-25352 Protein denotes IL-1β
T11270 25414-25428 Protein denotes TNF-α-mediated
T11276 25414-25445 Gene_expression denotes TNF-α-mediated MIP-2 expression
T11272 25414-25445 Regulation denotes TNF-α-mediated MIP-2 expression
T11259 25429-25434 Protein denotes MIP-2
T11244 25458-25460 Entity denotes SE
T11252 25469-25479 Entity denotes neutrophil
T11274 25495-25565 Gene_expression denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC
T11240 25539-25544 Protein denotes MIP-2
T11253 25559-25565 Protein denotes the PC
T11250 25608-25638 Entity denotes some MIP-2-positive astrocytes
T11269 25656-25664 Entity denotes the core
T11255 25793-25816 Entity denotes of MIP-2 positive cells
T11267 25796-25801 Protein denotes MIP-2
T11257 25838-25840 Protein denotes PC
T11251 26025-26048 Entity denotes of MIP-2 positive cells
T11271 26028-26033 Protein denotes MIP-2
T11266 26182-26187 Protein denotes MIP-2
T11243 26188-26202 Entity denotes positive cells
T11261 26377-26387 Entity denotes neutrophil
T11254 26408-26410 Protein denotes PC
T11262 26477-26487 Protein denotes that TNF-α
T11249 26501-26511 Entity denotes SE-induced
T11245 26512-26522 Entity denotes neutrophil
T11242 26548-26554 Protein denotes the PC
T11265 26597-26618 Protein denotes direct TNF-α-mediated
T11277 26597-26649 Regulation denotes direct TNF-α-mediated MIP-2 expression in astrocytes
T11275 26597-26649 Gene_expression denotes direct TNF-α-mediated MIP-2 expression in astrocytes
T11258 26619-26624 Protein denotes MIP-2
T11248 26639-26649 Entity denotes astrocytes
T14368 26712-26717 Protein denotes TNF-α
T14402 26712-26727 Positive_regulation denotes TNF-α signaling
T14374 26766-26771 Protein denotes NF-κB
T14403 26766-26787 Phosphorylation denotes NF-κB phosphorylation
T14375 26791-26797 Entity denotes the PC
T14273 26808-26810 Entity denotes SE
T14335 26874-26884 Entity denotes neutrophil
T14258 27026-27049 Entity denotes the extracellular space
T14263 27267-27272 Protein denotes TNF-α
T14303 27316-27348 Entity denotes microglia in the PC following SE
T14315 27329-27348 Protein denotes the PC following SE
T14378 27346-27348 Protein denotes SE
T14276 27350-27353 Protein denotes TNF
T14278 27350-27374 Protein denotes TNF receptor expressions
T14376 27401-27433 Entity denotes astrocytes (TNFp55R and TNFp75R)
T14381 27438-27465 Entity denotes endothelial cells (TNFp75R)
T14337 27457-27464 Protein denotes TNFp75R
T14400 27489-27507 Positive_regulation denotes of TNF-α signaling
T14287 27492-27497 Protein denotes TNF-α
T14312 27508-27527 Entity denotes by sTNFp55 infusion
T14325 27580-27590 Entity denotes SE-induced
T14354 27630-27636 Protein denotes the PC
T14350 27667-27672 Protein denotes TNF-α
T14299 27732-27735 Entity denotes SE,
T14261 27758-27768 Entity denotes SE-induced
T14314 27810-27815 Protein denotes TNF-α
T14405 27810-27825 Positive_regulation denotes TNF-α signaling
T14301 27920-27936 Entity denotes sTNFp55 infusion
T14389 27966-27976 Entity denotes SE-induced
T14280 28016-28022 Protein denotes the PC
T14328 28061-28066 Protein denotes TNF-α
T14409 28061-28076 Positive_regulation denotes TNF-α signaling
T14327 28144-28147 Protein denotes p65
T14398 28144-28172 Phosphorylation denotes p65 phosphorylation of NF-κB
T14275 28164-28172 Protein denotes of NF-κB
T14290 28217-28220 Protein denotes p65
T14412 28217-28236 Phosphorylation denotes p65 phosphorylation
T14336 28254-28267 Entity denotes the cytoplasm
T14297 28271-28287 Entity denotes the nucleus [30]
T14292 28311-28321 Entity denotes p65-Thr435
T14361 28311-28321 Protein denotes p65-Thr435
T14386 28315-28321 Entity denotes Thr435
T14334 28355-28372 Entity denotes endothelial cells
T14342 28496-28504 Entity denotes antigen,
T14310 28508-28564 Protein denotes a protein expressed by endothelial cells of rat BBB [31]
T14410 28508-28564 Gene_expression denotes a protein expressed by endothelial cells of rat BBB [31]
T14266 28528-28564 Entity denotes by endothelial cells of rat BBB [31]
T14330 28626-28657 Entity denotes endothelial cells [5,7,8,30,32]
T14366 28847-28899 Entity denotes of intercellular junctions between endothelial cells
T14358 28882-28899 Entity denotes endothelial cells
T14370 28992-29008 Entity denotes endothelial cell
T14298 29129-29131 Entity denotes SE
T14329 29201-29218 Entity denotes sTNFp55R infusion
T14284 29202-29205 Protein denotes TNF
T14293 29241-29251 Entity denotes SE-induced
T14395 29292-29340 Phosphorylation denotes the phosphorylation of p65-Thr435 by TNF-α [39],
T14300 29312-29325 Protein denotes of p65-Thr435
T14371 29312-29325 Entity denotes of p65-Thr435
T14352 29326-29339 Protein denotes by TNF-α [39]
T14268 29368-29382 Protein denotes TNF-α-mediated
T14406 29368-29430 Regulation denotes TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
T14291 29383-29393 Protein denotes p65-Thr435
T14347 29383-29393 Entity denotes p65-Thr435
T14388 29413-29430 Entity denotes endothelial cells
T14365 29608-29650 Protein denotes dystrophin (an actin-binding protein [40])
T14295 29620-29649 Protein denotes an actin-binding protein [40]
T14279 29747-29768 Protein denotes down-regulated 12 hrs
T14408 29747-29768 Negative_regulation denotes down-regulated 12 hrs
T14355 29775-29777 Protein denotes SE
T14269 29986-30003 Entity denotes endothelial cells
T14379 30008-30031 Entity denotes perivascular astrocytes
T14346 30055-30058 Protein denotes p65
T14307 30059-30065 Entity denotes Ser276
T14321 30067-30070 Protein denotes p65
T14294 30071-30077 Entity denotes Ser311
T14391 30079-30082 Protein denotes p65
T14377 30083-30089 Entity denotes Ser529
T14383 30095-30105 Entity denotes p65-Ser536
T14356 30095-30105 Protein denotes p65-Ser536
T14397 30095-30161 Phosphorylation denotes p65-Ser536 phosphorylation was observed in astrocytes following SE
T14344 30138-30161 Entity denotes astrocytes following SE
T14364 30159-30161 Protein denotes SE
T14304 30176-30193 Entity denotes sTNFp55R infusion
T14349 30177-30180 Protein denotes TNF
T14267 30216-30226 Protein denotes p65-Ser276
T14384 30216-30226 Entity denotes p65-Ser276
T14351 30260-30270 Entity denotes astrocytes
T14309 30281-30283 Protein denotes SE
T14399 30314-30333 Positive_regulation denotes enhanced p65-Ser276
T14360 30314-30333 Protein denotes enhanced p65-Ser276
T14340 30314-30333 Entity denotes enhanced p65-Ser276
T14380 30338-30348 Protein denotes p65-Ser311
T14369 30338-30348 Entity denotes p65-Ser311
T14413 30338-30364 Phosphorylation denotes p65-Ser311 phosphorylation
T14296 30384-30389 Protein denotes TNF-α
T14353 30424-30441 Entity denotes sTNFp55R infusion
T14390 30425-30428 Protein denotes TNF
T14289 30460-30470 Entity denotes p65-Ser529
T14363 30460-30470 Protein denotes p65-Ser529
T14332 30475-30502 Entity denotes p65-Ser536 phosphorylations
T14373 30475-30502 Protein denotes p65-Ser536 phosphorylations
T14331 30508-30510 Entity denotes SE
T14359 30526-30536 Protein denotes p65-Ser529
T14345 30526-30536 Entity denotes p65-Ser529
T14302 30541-30551 Entity denotes p65-Ser536
T14382 30541-30551 Protein denotes p65-Ser536
T14318 30574-30579 Protein denotes TNF-α
T14324 30584-30595 Protein denotes IL-1β [41],
T14272 30614-30628 Protein denotes IL-1β-mediated
T14357 30687-30697 Entity denotes SE-induced
T14322 30758-30763 Protein denotes TNF-α
T14281 30768-30773 Protein denotes IL-1β
T14372 30781-30799 Entity denotes synergists to play
T14316 30820-30837 Entity denotes endothelial cells
T14306 30855-30865 Entity denotes astrocytes
T14323 30912-30922 Entity denotes Neutrophil
T14271 31005-31010 Protein denotes of SE
T14333 31028-31030 Entity denotes SE
T14311 31064-31066 Entity denotes SE
T14288 31110-31120 Protein denotes chemokines
T14313 31176-31181 Protein denotes MIP-2
T14264 31198-31218 Entity denotes efficient neutrophil
T14282 31222-31232 Entity denotes lymphocyte
T14411 31222-31269 Binding denotes lymphocyte recruitment to brain parenchyma [43]
T14262 31299-31309 Entity denotes neutrophil
T14404 31366-31408 Gene_expression denotes by P2X7 receptor-mediated MIP-2 expression
T14401 31366-31408 Regulation denotes by P2X7 receptor-mediated MIP-2 expression
T14317 31369-31373 Protein denotes P2X7
T14285 31374-31391 Protein denotes receptor-mediated
T14270 31392-31397 Protein denotes MIP-2
T14343 31413-31420 Protein denotes the PC,
T14394 31454-31472 Entity denotes agonist/antagonist
T14348 31454-31472 Entity denotes agonist/antagonist
T14341 31462-31472 Entity denotes antagonist
T14362 31477-31505 Protein denotes IL-1Ra (an IL-1β antagonist)
T14393 31477-31514 Entity denotes IL-1Ra (an IL-1β antagonist) infusion
T14319 31485-31504 Protein denotes an IL-1β antagonist
T14392 31532-31541 Entity denotes leukocyte
T14326 31579-31586 Entity denotes TNFp55R
T14367 31579-31586 Protein denotes TNFp55R
T14260 31587-31595 Entity denotes infusion
T14283 31618-31628 Entity denotes neutrophil
T14274 31645-31651 Protein denotes the PC
T14407 31655-31719 Negative_regulation denotes reducing vasogenic edema formation in a MIP-2-independent manner
T14339 31695-31712 Protein denotes MIP-2-independent
T14338 31827-31835 Protein denotes by TNF-α
T14286 31847-31857 Entity denotes neutrophil
T14387 31925-31932 Protein denotes the PC,
T14308 32016-32032 Entity denotes endothelial cell
T14320 32046-32060 Protein denotes TNF-α mediated
T14414 32046-32060 Regulation denotes TNF-α mediated
T14265 32046-32094 Protein denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14259 32046-32094 Entity denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14396 32046-32094 Phosphorylation denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14305 32073-32078 Protein denotes NF-κB
T14385 32114-32116 Entity denotes SE
T14277 32163-32173 Entity denotes neutrophil
R11186 T14259 T14305 partOf TNF-α mediated p65-Thr 435 NF-κB phosphorylation,NF-κB
R11187 T14259 T14396 siteOf TNF-α mediated p65-Thr 435 NF-κB phosphorylation,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11189 T14268 T14406 causeOf TNF-α-mediated,TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
R11192 T14270 T14404 themeOf MIP-2,by P2X7 receptor-mediated MIP-2 expression
R11195 T14275 T14398 themeOf of NF-κB,p65 phosphorylation of NF-κB
R11196 T14279 T14408 themeOf down-regulated 12 hrs,down-regulated 12 hrs
R11197 T14285 T14401 causeOf receptor-mediated,by P2X7 receptor-mediated MIP-2 expression
R11198 T14287 T14400 causeOf TNF-α,of TNF-α signaling
R11199 T14290 T14412 themeOf p65,p65 phosphorylation
R11200 T14380 T14413 themeOf p65-Ser311,p65-Ser311 phosphorylation
R11201 T14383 T14356 partOf p65-Ser536,p65-Ser536
R11202 T14383 T14397 siteOf p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11203 T14300 T14395 themeOf of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11204 T14305 T14396 themeOf NF-κB,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11205 T14310 T14410 themeOf a protein expressed by endothelial cells of rat BBB [31],a protein expressed by endothelial cells of rat BBB [31]
R11206 T14404 T14401 themeOf by P2X7 receptor-mediated MIP-2 expression,by P2X7 receptor-mediated MIP-2 expression
R11207 T14314 T14405 causeOf TNF-α,TNF-α signaling
R11208 T14320 T14396 causeOf TNF-α mediated,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11209 T14320 T14414 themeOf TNF-α mediated,TNF-α mediated
R11210 T14327 T14398 causeOf p65,p65 phosphorylation of NF-κB
R11211 T14328 T14409 causeOf TNF-α,TNF-α signaling
R11212 T14352 T14395 causeOf by TNF-α [39],"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11213 T14356 T14397 themeOf p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11214 T14360 T14399 themeOf enhanced p65-Ser276,enhanced p65-Ser276
R11215 T14368 T14402 causeOf TNF-α,TNF-α signaling
R11216 T14369 T14380 partOf p65-Ser311,p65-Ser311
R11217 T14369 T14413 siteOf p65-Ser311,p65-Ser311 phosphorylation
R11218 T14371 T14300 partOf of p65-Thr435,of p65-Thr435
R11219 T14371 T14395 siteOf of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11220 T14374 T14403 themeOf NF-κB,NF-κB phosphorylation
R11360 T14671 T14686 themeOf TNF receptor,Expression of TNF-α and TNF receptor in the PC 12 hr-post
R11361 T14674 T14685 themeOf TNF-α,Expression of TNF-α and TNF receptor in the PC 12 hr-post
R11362 T14675 T14683 themeOf TNFp75R,TNFp75R expression in astrocytes as well as endothelial cells (arrows)
R11363 T14682 T14684 themeOf TNFp55R,TNFp55R expression in astrocytes (arrows)
R11906 T15414 T15433 themeOf p65-Ser536 (H),p65-Ser536 (H) phosphorylation
R11907 T15421 T15435 themeOf p65-Ser536 (G),p65-Ser536 (G) phosphorylation
R11908 T15423 T15434 themeOf NF-κB,on NF-κB phosphorylation in astrocytes
R11909 T15426 T15421 partOf p65-Ser536 (G),p65-Ser536 (G)
R11910 T15426 T15435 siteOf p65-Ser536 (G),p65-Ser536 (G) phosphorylation
R11911 T15432 T15414 partOf p65-Ser536 (H),p65-Ser536 (H)
R11912 T15432 T15433 siteOf p65-Ser536 (H),p65-Ser536 (H) phosphorylation
R12099 T15681 T15692 themeOf p65-Thr435,p65-Thr435 phosphorylation
R12100 T15682 T15693 themeOf NF-κB,NF-κB phosphorylation
R12101 T15683 T15681 partOf p65-Thr435,p65-Thr435
R12102 T15683 T15692 siteOf p65-Thr435,p65-Thr435 phosphorylation
R12103 T15689 T15694 themeOf NF-κB,of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M)
R12364 T16182 T16189 partOf p65-Thr435,p65-Thr435
R12365 T16182 T16218 siteOf p65-Thr435,of p65-Thr435 phosphorylation
R12366 T16184 T16202 partOf p65-Thr435,p65-Thr435
R12367 T16184 T16219 siteOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
R12368 T16189 T16218 themeOf p65-Thr435,of p65-Thr435 phosphorylation
R12369 T16194 T16214 themeOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
R12370 T16196 T16199 partOf p65-Thr435,p65-Thr435
R12371 T16196 T16216 siteOf p65-Thr435,p65-Thr435 phosphorylation
R12372 T16197 T16217 themeOf p65-Thr435,p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
R12373 T16199 T16216 themeOf p65-Thr435,p65-Thr435 phosphorylation
R12374 T16201 T16194 partOf p65-Thr435,p65-Thr435
R12375 T16201 T16214 siteOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
R12376 T16202 T16219 themeOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
R12377 T16206 T16215 themeOf Endothelial p65-Thr435 phosphorylation in non-SE animals,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12378 T16207 T16206 partOf Thr435,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12379 T16207 T16215 siteOf Thr435,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12380 T16212 T16197 partOf p65-Thr435,p65-Thr435
R12381 T16212 T16217 siteOf p65-Thr435,p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
R12382 T16216 T16213 themeOf p65-Thr435 phosphorylation,p65-Thr435 phosphorylation is enhanced
R12823 T16800 T16816 themeOf MIP-2,MIP-2 expression
R12824 T16807 T16815 themeOf MIP-2,MIP-2 expression in the PC 1 day after SE
R2144 T2861 T2936 themeOf MIP-2,mediated MIP-2 expression
R2145 T2874 T2935 causeOf TNF-α,TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2152 T2912 T2934 themeOf macrophage inflammatory protein-2 (MIP-2),TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2154 T2936 T2933 themeOf mediated MIP-2 expression,mediated MIP-2 expression
R2155 T2912 T2935 themeOf macrophage inflammatory protein-2 (MIP-2),TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2156 T2918 T2932 themeOf MIP-2,"Neurons, microglia, and astrocytes produce MIP-2 when incubated with pro-inflammatory cytokines such as TNF-α"
R3027 T3917 T3934 themeOf divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor,divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
R6898 T8277 T8304 themeOf "TNF-α, and TNF receptor","TNF-α, and TNF receptor expression"
R7597 T9296 T9307 partOf p65-Ser311,p65-Ser311
R7598 T9296 T9338 siteOf p65-Ser311,p65-Ser311 phosphorylation
R7599 T9298 T9337 themeOf p65-Thr435,p65-Thr435 phosphorylation
R7600 T9306 T9342 themeOf NF-κB,NF-κB phosphorylation
R7601 T9307 T9338 themeOf p65-Ser311,p65-Ser311 phosphorylation
R7602 T9313 T9341 themeOf p65-Ser536,p65-Ser536 phosphorylation
R7603 T9314 T9327 partOf p65-Ser536,p65-Ser536
R7604 T9314 T9340 siteOf p65-Ser536,p65-Ser536 phosphorylation
R7605 T9321 T9298 partOf p65-Thr435,p65-Thr435
R7606 T9321 T9337 siteOf p65-Thr435,p65-Thr435 phosphorylation
R7607 T9323 T9313 partOf p65-Ser536,p65-Ser536
R7608 T9323 T9341 siteOf p65-Ser536,p65-Ser536 phosphorylation
R7609 T9327 T9340 themeOf p65-Ser536,p65-Ser536 phosphorylation
R7610 T9331 T9339 themeOf of NF-κB,phosphorylation of NF-κB
R7611 T9337 T9336 themeOf p65-Thr435 phosphorylation,"In contrast, p65-Thr435 phosphorylation was increased in endothelial cells"
R7991 T9835 T9839 partOf p65-Thr435,p65-Thr435
R7992 T9835 T9855 siteOf p65-Thr435,was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
R7993 T9839 T9855 themeOf p65-Thr435,was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
R7994 T9843 T9848 partOf p65-Thr435,p65-Thr435
R7995 T9843 T9854 siteOf p65-Thr435,increased p65-Thr435 phosphorylation (Figures 5C-D)
R7996 T9848 T9854 themeOf p65-Thr435,increased p65-Thr435 phosphorylation (Figures 5C-D)
R7997 T9854 T9853 themeOf increased p65-Thr435 phosphorylation (Figures 5C-D),increased p65-Thr435 phosphorylation (Figures 5C-D)
R8401 T10353 T10363 causeOf TNF-α-mediated,to TNF-α-mediated vasogenic edema formation
R9028 T11240 T11274 themeOf MIP-2,"To confirm this hypothesis, we investigated MIP-2 expression in the PC"
R9029 T11256 T11273 themeOf MIP-2,MIP-2 expression
R9030 T11258 T11275 themeOf MIP-2,direct TNF-α-mediated MIP-2 expression in astrocytes
R9031 T11259 T11276 themeOf MIP-2,TNF-α-mediated MIP-2 expression
R9032 T11265 T11277 causeOf direct TNF-α-mediated,direct TNF-α-mediated MIP-2 expression in astrocytes
R9033 T11270 T11272 causeOf TNF-α-mediated,TNF-α-mediated MIP-2 expression
R9034 T11275 T11277 themeOf direct TNF-α-mediated MIP-2 expression in astrocytes,direct TNF-α-mediated MIP-2 expression in astrocytes
R9035 T11276 T11272 themeOf TNF-α-mediated MIP-2 expression,TNF-α-mediated MIP-2 expression