bionlp-st-ge-2016-test-ihmc  

PMC:3312845 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T935 0-23 Protein denotes Tumor necrosis factor-α
T987 0-116 Regulation denotes Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells
T938 33-46 Entity denotes threonine 435
T940 99-116 Entity denotes endothelial cells
T962 145-155 Entity denotes neutrophil
T967 266-268 Entity denotes SE
T970 325-327 Protein denotes PC
T974 407-417 Entity denotes SE-induced
T959 461-493 Protein denotes of tumor necrosis factor (TNF)-α
T934 612-637 Entity denotes by pilocarpine-induced SE
T958 615-634 Entity denotes pilocarpine-induced
T933 648-650 Protein denotes SE
T989 648-743 Positive_regulation denotes SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-,
T988 648-743 Gene_expression denotes SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-,
T966 663-677 Entity denotes by pilocarpine
T971 748-783 Protein denotes soluble TNF p55 receptor (sTNFp55R)
T942 774-782 Entity denotes sTNFp55R
T965 775-778 Protein denotes TNF
T950 793-795 Entity denotes SE
T979 832-843 Entity denotes Fluoro-Jade
T944 832-843 Entity denotes Fluoro-Jade
T977 839-843 Protein denotes Jade
T954 891-896 Protein denotes TNF-α
T957 901-906 Protein denotes NF-κB
T961 936-939 Protein denotes SE,
T968 940-964 Entity denotes most activated microglia
T975 979-984 Protein denotes TNF-α
T964 1016-1032 Protein denotes TNF p75 receptor
T983 1016-1043 Gene_expression denotes TNF p75 receptor expression
T978 1060-1099 Entity denotes endothelial cells as well as astrocytes
T951 1089-1099 Entity denotes astrocytes
T985 1114-1145 Phosphorylation denotes only p65-Thr435 phosphorylation
T986 1114-1159 Positive_regulation denotes only p65-Thr435 phosphorylation was increased
T939 1119-1129 Entity denotes p65-Thr435
T943 1119-1129 Protein denotes p65-Thr435
T963 1163-1213 Entity denotes endothelial cells accompanied by SMI-71 expression
T980 1238-1245 Entity denotes antigen
T972 1263-1271 Protein denotes of TNF-α
T932 1272-1310 Protein denotes by soluble TNF p55 receptor (sTNFp55R)
T952 1311-1319 Entity denotes infusion
T947 1331-1333 Entity denotes SE
T936 1394-1407 Entity denotes of p65-Thr435
T948 1394-1407 Protein denotes of p65-Thr435
T960 1427-1444 Entity denotes endothelial cells
T981 1459-1467 Entity denotes sTNFp55R
T953 1459-1467 Protein denotes sTNFp55R
T969 1468-1476 Entity denotes infusion
T955 1485-1495 Entity denotes SE-induced
T941 1496-1506 Entity denotes neutrophil
T949 1523-1529 Protein denotes the PC
T982 1586-1602 Entity denotes endothelial cell
T956 1617-1631 Protein denotes TNF-α-mediated
T990 1617-1665 Phosphorylation denotes TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
T984 1617-1665 Regulation denotes TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
T976 1617-1665 Entity denotes TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
T946 1617-1665 Protein denotes TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
T973 1644-1649 Protein denotes NF-κB
T945 1685-1695 Entity denotes SE-induced
T937 1764-1774 Entity denotes neutrophil
T2887 1850-1852 Entity denotes SE
T2859 1909-1911 Protein denotes SE
T2903 2075-2077 Protein denotes SE
T2890 2201-2203 Protein denotes PC
T2886 2292-2303 Entity denotes pilocarpine
T2884 2360-2395 Entity denotes Pilocarpine, a cholinergic agonist,
T2929 2373-2394 Entity denotes a cholinergic agonist
T2866 2404-2406 Entity denotes SE
T2904 2419-2469 Protein denotes This pilocarpine-induced SE, similar to human TLE,
T2905 2424-2443 Entity denotes pilocarpine-induced
T2878 2578-2589 Entity denotes pilocarpine
T2860 2699-2718 Entity denotes pilocarpine-induced
T2922 2699-2721 Entity denotes pilocarpine-induced SE
T2889 2763-2772 Entity denotes layers II
T2862 2784-2796 Protein denotes the PC [5,6]
T2925 2798-2800 Entity denotes SE
T2867 2840-2899 Protein denotes the PC accompanied by neuronal and astroglial damages [5-8]
T2893 2943-2952 Entity denotes cytotoxic
T2869 3003-3026 Entity denotes cytotoxic osmotic edema
T2930 3089-3092 Protein denotes SE,
T2910 3109-3122 Entity denotes intracellular
T2864 3109-3126 Entity denotes intracellular Na+
T2915 3131-3135 Entity denotes Ca2+
T2885 3200-3217 Entity denotes endothelial cells
T2865 4102-4125 Entity denotes of various interleukins
T2913 4200-4209 Protein denotes Cytokines
T2896 4217-4234 Entity denotes endothelial cells
T2882 4391-4404 Entity denotes dexamethasone
T2902 4464-4483 Entity denotes kainic acid-induced
T2880 4499-4508 Protein denotes cytokines
T2917 4510-4541 Protein denotes tumor necrosis factor-α (TNF-α)
T2900 4535-4540 Protein denotes TNF-α
T2926 4545-4643 Entity denotes a 17 kDa protein that is produced mainly by activated macrophages and T cells in the immune system
T2919 4545-4643 Protein denotes a 17 kDa protein that is produced mainly by activated macrophages and T cells in the immune system
T2870 4589-4610 Entity denotes activated macrophages
T2877 4615-4643 Entity denotes T cells in the immune system
T2879 4645-4650 Protein denotes TNF-α
T2868 4730-4737 Entity denotes neurons
T2906 4742-4759 Entity denotes endothelial cells
T2916 4812-4814 Entity denotes SE
T2909 4824-4829 Protein denotes TNF-α
T2892 4924-4939 Entity denotes of target cells
T2895 4969-4977 Protein denotes receptor
T2899 4987-5002 Protein denotes TNF receptor I,
T2894 5006-5009 Protein denotes p55
T2901 5006-5018 Protein denotes p55 receptor
T2920 5020-5027 Protein denotes TNFp55R
T2897 5034-5050 Protein denotes TNF receptor II,
T2883 5054-5076 Protein denotes p75 receptor (TNFp75R)
T2907 5068-5075 Protein denotes TNFp75R
T2874 5096-5101 Protein denotes TNF-α
T2935 5096-5151 Positive_regulation denotes TNF-α induces macrophage inflammatory protein-2 (MIP-2)
T2934 5096-5151 Gene_expression denotes TNF-α induces macrophage inflammatory protein-2 (MIP-2)
T2912 5110-5151 Protein denotes macrophage inflammatory protein-2 (MIP-2)
T2921 5145-5150 Protein denotes MIP-2
T2931 5157-5229 Binding denotes recruits neutrophils under pathological conditions, including SE [14,20]
T2928 5166-5177 Entity denotes neutrophils
T2914 5219-5229 Protein denotes SE [14,20]
T2888 5231-5238 Entity denotes Neurons
T2932 5231-5340 Gene_expression denotes Neurons, microglia, and astrocytes produce MIP-2 when incubated with pro-inflammatory cytokines such as TNF-α
T2871 5240-5249 Entity denotes microglia
T2875 5255-5265 Entity denotes astrocytes
T2918 5274-5279 Protein denotes MIP-2
T2881 5300-5334 Protein denotes pro-inflammatory cytokines such as
T2923 5300-5340 Protein denotes pro-inflammatory cytokines such as TNF-α
T2863 5348-5370 Protein denotes interleukin-1β (IL-1β)
T2924 5364-5369 Protein denotes IL-1β
T2908 5435-5437 Entity denotes SE
T2936 5438-5463 Gene_expression denotes mediated MIP-2 expression
T2933 5438-5463 Regulation denotes mediated MIP-2 expression
T2861 5447-5452 Protein denotes MIP-2
T2873 5479-5488 Entity denotes leukocyte
T2911 5513-5515 Protein denotes SE
T2927 5522-5539 Protein denotes IL-1β-independent
T2872 5591-5596 Protein denotes TNF-α
T2891 5802-5810 Protein denotes of TNF-α
T2876 5885-5910 Protein denotes by pilocarpine-induced SE
T2898 5888-5907 Entity denotes pilocarpine-induced
T3927 6715-6752 Entity denotes Intracerebroventricular drug infusion
T3924 6715-6752 Entity denotes Intracerebroventricular drug infusion
T3917 6763-6840 Protein denotes divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
T3934 6763-6840 Regulation denotes divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
T3930 6797-6803 Entity denotes saline
T3921 6843-6846 Protein denotes TNF
T3920 6862-6894 Protein denotes Sigma-Aldrich Co., St. Louis, MO
T3919 6912-6929 Protein denotes The dosage of sTN
T3922 6983-7070 Protein denotes SE of comparable severity in 100% of animals with 5% mortality in the preliminary study
T3932 7275-7297 Entity denotes a brain infusion kit 1
T3928 7414-7447 Entity denotes position with bregma as reference
T3926 7501-7517 Entity denotes The infusion kit
T3925 7752-7772 Entity denotes the dose of sTNFp55R
T3933 7765-7768 Protein denotes TNF
T3929 7927-7929 Entity denotes SE
T3931 8053-8061 Protein denotes of TNF-α
T3918 8067-8085 Protein denotes 3 days prior to SE
T3923 8089-8146 Entity denotes 4 days after SE when the volume of vasogenic edema peaked
T4406 8216-8239 Entity denotes pilocarpine (380 mg/kg,
T4403 8240-8264 Protein denotes i.p.; Sigma-Aldrich Co.,
T4399 8324-8348 Protein denotes i.p.; Sigma-Aldrich Co.,
T4396 8450-8490 Entity denotes Approximately 80% of pilocarpine treated
T4397 8468-8490 Entity denotes of pilocarpine treated
T4402 8532-8534 Entity denotes SE
T4398 8862-8881 Entity denotes pilocarpine-induced
T4404 8902-8921 Entity denotes Diazepam (10 mg/kg,
T4401 8902-8926 Protein denotes Diazepam (10 mg/kg, i.p.
T4408 9002-9007 Protein denotes of SE
T4400 9172-9183 Protein denotes SE (non-SE)
T4405 9242-9250 Entity denotes min, n =
T4407 9305-9308 Entity denotes n =
T4737 9359-9423 Protein denotes non-SE: 12 hr, 1 day, 2 days, 3 days, 4 days and 1 week after SE
T4733 9425-9428 Entity denotes n =
T4732 9496-9514 Entity denotes phosphate-buffered
T4734 9496-9527 Entity denotes phosphate-buffered saline (PBS)
T4739 9537-9559 Entity denotes by 4% paraformaldehyde
T4735 9569-9578 Entity denotes phosphate
T4729 9587-9589 Protein denotes PB
T4736 9605-9624 Entity denotes urethane anesthesia
T4738 9642-9671 Protein denotes Sigma-Aldrich Co., St. Louis,
T4730 9719-9745 Entity denotes the same fixative for 4 hr
T4731 9805-9826 Entity denotes 30% sucrose overnight
T5358 10260-10279 Protein denotes rabbit anti-MPO IgG
T5356 10391-10428 Entity denotes 0.3% Triton X-100 (Sigma-Aldrich Co.,
T5363 10410-10427 Protein denotes Sigma-Aldrich Co.
T5349 10469-10486 Protein denotes Sigma-Aldrich Co.
T5355 10696-10728 Entity denotes ABC complex (Vector, Burlingame,
T5352 10751-10768 Entity denotes the same solution
T5360 10948-10962 Protein denotes serum-proteins
T5350 11016-11034 Protein denotes a primary antibody
T5359 11070-11097 Entity denotes 3,3'-diaminobenzidine (DAB,
T5353 11070-11115 Protein denotes 3,3'-diaminobenzidine (DAB, Sigma-Aldrich Co.
T5362 11135-11145 Entity denotes 0.1 M Tris
T5351 11371-11383 Protein denotes the antibody
T5354 11419-11435 Entity denotes purified peptide
T5357 11511-11531 Entity denotes the primary antibody
T5361 11612-11628 Entity denotes primary antibody
T5840 11692-11729 Protein denotes 3% bovine serum albumin in PBS for 30
T5845 12674-12692 Entity denotes a mixture of FITC-
T5844 12687-12692 Entity denotes FITC-
T5841 12907-12929 Entity denotes nuclei counterstaining
T5843 12972-12976 Entity denotes DAPI
T5839 13047-13049 Entity denotes M2
T5842 13065-13079 Protein denotes AxioVision Rel
T6352 13096-13109 Entity denotes Fluoro-Jade B
T6350 13119-13138 Entity denotes Fluoro-Jade B (FJB)
T6361 13182-13237 Binding denotes neurons in tissues obtained from non-SE and 3 days post
T6349 13182-13237 Entity denotes neurons in tissues obtained from non-SE and 3 days post
T6360 13364-13366 Entity denotes SE
T6345 13406-13408 Protein denotes SE
T6359 13596-13608 Entity denotes 100% ethanol
T6357 13629-13649 Entity denotes by 70% ethanol for 2
T6358 13721-13756 Entity denotes 0.06% potassium permanganate for 15
T6351 13906-13908 Protein denotes AR
T6355 13961-14004 Entity denotes FJB solution to 180 ml of 0.1% acetic acid,
T6354 13977-14004 Entity denotes 180 ml of 0.1% acetic acid,
T6353 13984-14003 Entity denotes of 0.1% acetic acid
T6346 14144-14150 Entity denotes xylene
T6356 14173-14196 Protein denotes DPX (Sigma-Aldrich Co.,
T6348 14178-14195 Protein denotes Sigma-Aldrich Co.
T6347 14283-14296 Protein denotes the entire PC
T7146 14344-14348 Entity denotes cell
T7140 14430-14432 Protein denotes PC
T7134 14601-14618 Protein denotes by AxioVision Rel
T7151 14702-14705 Protein denotes ssf
T7133 14905-14908 Protein denotes mm3
T7142 14955-14967 Entity denotes cell numbers
T7137 15358-15363 Entity denotes h; 15
T7139 15408-15429 Entity denotes of each cell type (C)
T7132 15483-15484 Entity denotes t
T7136 15485-15486 Entity denotes h
T7141 15499-15502 Protein denotes ssf
T7144 15527-15535 Entity denotes of cells
T7148 15662-15665 Protein denotes Asf
T7150 15900-15905 Protein denotes asf =
T7135 15932-15956 Entity denotes The immunoreactive cells
T7149 15997-16021 Entity denotes The immunoreactive cells
T7145 16062-16086 Entity denotes All immunoreactive cells
T7147 16138-16142 Entity denotes Cell
T7138 16245-16255 Entity denotes SE-induced
T7131 16245-16266 Protein denotes SE-induced PC atrophy
T7143 16355-16364 Protein denotes of the PC
T7130 16394-16402 Entity denotes of cells
T7645 16792-16806 Protein denotes AxioVision Rel
T7644 16910-16916 Protein denotes the PC
T7647 16979-17016 Protein denotes the PC (15 sections from each animal)
T7643 17128-17165 Entity denotes n = 36 per region examined, in non-SE
T7648 17394-17494 Negative_regulation denotes Manipulation of the images was restricted to threshold and brightness adjustments to the whole image
T7646 17603-17617 Protein denotes AxioVision Rel
T7776 17888-17892 Entity denotes cell
T7775 18134-18140 Protein denotes of MPO
T8296 18180-18186 Protein denotes TNF-α,
T8277 18180-18203 Protein denotes TNF-α, and TNF receptor
T8304 18180-18214 Gene_expression denotes TNF-α, and TNF receptor expression
T8297 18191-18194 Protein denotes TNF
T8302 18271-18276 Protein denotes TNF-α
T8290 18317-18319 Protein denotes PC
T8288 18317-18344 Entity denotes PC neurons (data not shown)
T8281 18360-18362 Protein denotes SE
T8295 18400-18431 Entity denotes most of the activated microglia
T8301 18405-18431 Entity denotes of the activated microglia
T8286 18446-18451 Protein denotes TNF-α
T8282 18510-18542 Protein denotes maintained up to 1 week after SE
T8293 18547-18553 Entity denotes non-SE
T8283 18600-18607 Protein denotes TNFp55R
T8280 18612-18619 Protein denotes TNFp75R
T8303 18668-18695 Entity denotes astrocytes (data not shown)
T8300 18711-18713 Protein denotes SE
T8278 18751-18758 Protein denotes TNFp55R
T8287 18792-18814 Entity denotes astrocytes (Figure 1B)
T8299 18823-18831 Protein denotes TNFp55R,
T8292 18832-18839 Protein denotes TNFp75R
T8285 18873-18890 Entity denotes endothelial cells
T8279 18902-18912 Entity denotes astrocytes
T8284 18953-18956 Protein denotes SE,
T8298 18962-18969 Protein denotes TNFp55R
T8289 18974-18981 Protein denotes TNFp75R
T8291 19031-19042 Entity denotes astrocytes,
T8294 19050-19068 Entity denotes endothelial cells,
T14686 19139-19196 Gene_expression denotes Expression of TNF-α and TNF receptor in the PC 12 hr-post
T14685 19139-19196 Gene_expression denotes Expression of TNF-α and TNF receptor in the PC 12 hr-post
T14674 19153-19158 Protein denotes TNF-α
T14681 19163-19166 Protein denotes TNF
T14671 19163-19175 Protein denotes TNF receptor
T14679 19183-19185 Protein denotes PC
T14672 19197-19199 Protein denotes SE
T14676 19205-19210 Protein denotes TNF-α
T14673 19228-19264 Entity denotes in Ox-42-positive microglia (arrows)
T14682 19270-19277 Protein denotes TNFp55R
T14684 19270-19311 Gene_expression denotes TNFp55R expression in astrocytes (arrows)
T14680 19292-19311 Entity denotes astrocytes (arrows)
T14675 19319-19326 Protein denotes TNFp75R
T14683 19319-19389 Gene_expression denotes TNFp75R expression in astrocytes as well as endothelial cells (arrows)
T14670 19341-19351 Entity denotes astrocytes
T14677 19363-19389 Entity denotes endothelial cells (arrows)
T14678 19391-19396 Entity denotes Bar =
T8583 19418-19438 Entity denotes of sTNFp55R infusion
T8588 19422-19425 Protein denotes TNF
T8582 19442-19452 Entity denotes SE-induced
T8571 19442-19480 Entity denotes SE-induced serum-protein extravasation
T8570 19442-19480 Protein denotes SE-induced serum-protein extravasation
T8574 19615-19631 Protein denotes 3 days after SE,
T8587 19689-19691 Entity denotes SE
T8589 19739-19759 Entity denotes of sTNFp55R infusion
T8576 19743-19746 Protein denotes TNF
T8569 19813-19818 Entity denotes by SE
T8578 19823-19837 Entity denotes saline-treated
T8581 19847-19853 Protein denotes the PC
T8579 19952-19967 Protein denotes mm3 (Figure 2E)
T8575 19980-20003 Entity denotes of FJB-positive neurons
T8568 20007-20013 Protein denotes the PC
T8580 20052-20055 Protein denotes TNF
T8577 20077-20087 Entity denotes SE-induced
T8585 20132-20155 Protein denotes mm3 (Figures 2C and 2E)
T8586 20181-20204 Entity denotes of FJB-positive neurons
T8584 20208-20214 Protein denotes the PC
T8573 20256-20273 Entity denotes sTNFp55R infusion
T8572 20257-20260 Protein denotes TNF
T8567 20285-20295 Entity denotes SE-induced
T14928 20396-20416 Entity denotes of sTNFp55R infusion
T14933 20400-20403 Protein denotes TNF
T14940 20420-20430 Entity denotes SE-induced
T14932 20420-20458 Entity denotes SE-induced serum-protein extravasation
T14927 20420-20458 Protein denotes SE-induced serum-protein extravasation
T14941 20486-20499 Protein denotes Serum-protein
T14942 20486-20513 Entity denotes Serum-protein extravasation
T14935 20551-20573 Protein denotes the PC 3 days after SE
T14938 20571-20573 Protein denotes SE
T14930 20611-20638 Protein denotes serum-protein extravasation
T14937 20725-20731 Entity denotes Bars =
T14936 20796-20823 Protein denotes serum-protein extravasation
T14931 20796-20823 Entity denotes serum-protein extravasation
T14939 20860-20873 Protein denotes the PC 3 days
T14929 20880-20897 Entity denotes SE (mean ± S.E.M)
T14934 20928-20934 Entity denotes saline
T9306 20964-20969 Protein denotes NF-κB
T9342 20964-20985 Phosphorylation denotes NF-κB phosphorylation
T9303 21014-21019 Protein denotes TNF-α
T9339 21055-21079 Phosphorylation denotes phosphorylation of NF-κB
T9331 21071-21079 Protein denotes of NF-κB
T9312 21092-21106 Protein denotes TNF-α-mediated
T9305 21092-21130 Entity denotes TNF-α-mediated signaling following SE,
T9335 21179-21208 Entity denotes five phospho-NF-κB antibodies
T9300 21192-21197 Protein denotes NF-κB
T9322 21266-21268 Protein denotes SE
T9333 21280-21290 Entity denotes the saline
T9301 21312-21322 Entity denotes p65-Ser276
T9292 21312-21322 Protein denotes p65-Ser276
T9315 21324-21334 Protein denotes p65-Ser311
T9308 21324-21334 Entity denotes p65-Ser311
T9320 21336-21346 Entity denotes p65-Ser529
T9295 21336-21346 Protein denotes p65-Ser529
T9327 21352-21362 Protein denotes p65-Ser536
T9314 21352-21362 Entity denotes p65-Ser536
T9340 21352-21378 Phosphorylation denotes p65-Ser536 phosphorylation
T9325 21382-21392 Entity denotes astrocytes
T9330 21398-21415 Entity denotes endothelial cells
T9334 21418-21435 Entity denotes sTNFp55R infusion
T9302 21419-21422 Protein denotes TNF
T9309 21456-21466 Entity denotes p65-Ser276
T9299 21456-21466 Protein denotes p65-Ser276
T9307 21471-21481 Protein denotes p65-Ser311
T9296 21471-21481 Entity denotes p65-Ser311
T9338 21471-21497 Phosphorylation denotes p65-Ser311 phosphorylation
T9326 21499-21500 Entity denotes p
T9332 21550-21560 Protein denotes p65-Ser529
T9311 21550-21560 Entity denotes p65-Ser529
T9323 21564-21574 Entity denotes p65-Ser536
T9313 21564-21574 Protein denotes p65-Ser536
T9341 21564-21590 Phosphorylation denotes p65-Ser536 phosphorylation
T9336 21611-21685 Positive_regulation denotes In contrast, p65-Thr435 phosphorylation was increased in endothelial cells
T9321 21624-21634 Entity denotes p65-Thr435
T9298 21624-21634 Protein denotes p65-Thr435
T9337 21624-21650 Phosphorylation denotes p65-Thr435 phosphorylation
T9293 21668-21685 Entity denotes endothelial cells
T9324 21691-21701 Entity denotes astrocytes
T9297 21710-21742 Protein denotes the PC of saline-infused animals
T9317 21755-21769 Protein denotes SE (Figure 5A)
T9329 21785-21788 Protein denotes TNF
T9316 21785-21801 Entity denotes TNFp55R infusion
T9294 21825-21835 Entity denotes SE-induced
T9318 21825-21846 Entity denotes SE-induced p65-Thr435
T9291 21825-21846 Protein denotes SE-induced p65-Thr435
T9319 21866-21884 Entity denotes endothelial cells,
T9328 21894-21903 Entity denotes to saline
T9304 21904-21912 Entity denotes infusion
T9310 21914-21915 Entity denotes p
T15416 21953-21973 Entity denotes of sTNFp55R infusion
T15417 21957-21960 Protein denotes TNF
T15434 21974-22012 Phosphorylation denotes on NF-κB phosphorylation in astrocytes
T15423 21977-21982 Protein denotes NF-κB
T15424 22002-22012 Entity denotes astrocytes
T15430 22025-22027 Entity denotes SE
T15413 22043-22045 Protein denotes SE
T15431 22099-22109 Entity denotes astrocytes
T15411 22115-22125 Entity denotes p65-Ser276
T15402 22115-22125 Protein denotes p65-Ser276
T15404 22131-22145 Entity denotes p65-Ser311 (C)
T15401 22131-22145 Protein denotes p65-Ser311 (C)
T15419 22147-22161 Entity denotes p65-Ser529 (E)
T15406 22147-22161 Protein denotes p65-Ser529 (E)
T15426 22167-22181 Entity denotes p65-Ser536 (G)
T15421 22167-22181 Protein denotes p65-Ser536 (G)
T15435 22167-22197 Phosphorylation denotes p65-Ser536 (G) phosphorylation
T15420 22208-22216 Protein denotes sTNFp55R
T15415 22208-22216 Entity denotes sTNFp55R
T15425 22217-22241 Entity denotes infusion (B, D, F and H)
T15407 22239-22240 Entity denotes H
T15428 22262-22276 Protein denotes p65-Ser276 (B)
T15418 22262-22276 Entity denotes p65-Ser276 (B)
T15427 22266-22272 Entity denotes Ser276
T15410 22281-22295 Entity denotes p65-Ser311 (D)
T15408 22281-22295 Protein denotes p65-Ser311 (D)
T15409 22285-22291 Entity denotes Ser311
T15422 22338-22352 Entity denotes p65-Ser529 (F)
T15403 22338-22352 Protein denotes p65-Ser529 (F)
T15429 22350-22351 Entity denotes F
T15432 22357-22371 Entity denotes p65-Ser536 (H)
T15414 22357-22371 Protein denotes p65-Ser536 (H)
T15433 22357-22387 Phosphorylation denotes p65-Ser536 (H) phosphorylation
T15412 22369-22370 Entity denotes H
T15405 22398-22411 Protein denotes Bar = 12.5 μm
T15685 22459-22479 Entity denotes of sTNFp55R infusion
T15680 22463-22466 Protein denotes TNF
T15682 22483-22488 Protein denotes NF-κB
T15693 22483-22504 Phosphorylation denotes NF-κB phosphorylation
T15694 22554-22608 Phosphorylation denotes of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M)
T15689 22557-22562 Protein denotes NF-κB
T15684 22591-22608 Entity denotes SE (mean ± S.E.M)
T15686 22639-22645 Entity denotes saline
T15690 22678-22735 Protein denotes Quantitative analysis of SMI-71 expression 1 day after SE
T15687 22781-22787 Entity denotes saline
T15683 22855-22865 Entity denotes p65-Thr435
T15681 22855-22865 Protein denotes p65-Thr435
T15692 22855-22881 Phosphorylation denotes p65-Thr435 phosphorylation
T15688 22896-22915 Protein denotes the PC following SE
T15691 22913-22915 Entity denotes SE
T16211 22927-23005 Protein denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16204 22927-23005 Entity denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16198 22927-23005 Protein denotes Effect of sTNFp55R infusion on p65-Thr435 phosphorylation in endothelial cells
T16208 22962-22968 Entity denotes Thr435
T16181 22988-23005 Entity denotes endothelial cells
T16178 23016-23018 Protein denotes SE
T16218 23037-23066 Phosphorylation denotes of p65-Thr435 phosphorylation
T16189 23040-23050 Protein denotes p65-Thr435
T16182 23040-23050 Entity denotes p65-Thr435
T16193 23067-23087 Entity denotes by sTNFp55R infusion
T16200 23071-23074 Protein denotes TNF
T16191 23100-23102 Entity denotes SE
T16212 23104-23114 Entity denotes p65-Thr435
T16197 23104-23114 Protein denotes p65-Thr435
T16217 23104-23172 Phosphorylation denotes p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
T16180 23153-23172 Entity denotes astrocytes (arrows)
T16215 23178-23234 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in non-SE animals
T16206 23178-23234 Protein denotes Endothelial p65-Thr435 phosphorylation in non-SE animals
T16207 23194-23200 Entity denotes Thr435
T16205 23237-23240 Entity denotes D-E
T16219 23242-23321 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
T16202 23254-23264 Protein denotes p65-Thr435
T16184 23254-23264 Entity denotes p65-Thr435
T16183 23284-23321 Protein denotes saline-infused animals 1 day after SE
T16199 23323-23333 Protein denotes p65-Thr435
T16196 23323-23333 Entity denotes p65-Thr435
T16216 23323-23349 Phosphorylation denotes p65-Thr435 phosphorylation
T16213 23323-23361 Positive_regulation denotes p65-Thr435 phosphorylation is enhanced
T16220 23363-23443 Negative_regulation denotes while SMI-71 expression is reduced in GLUT-1-positive endothelial cells (arrows)
T16190 23401-23407 Protein denotes GLUT-1
T16210 23408-23434 Entity denotes positive endothelial cells
T16214 23451-23531 Phosphorylation denotes Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
T16201 23463-23473 Entity denotes p65-Thr435
T16194 23463-23473 Protein denotes p65-Thr435
T16195 23493-23531 Entity denotes sTNFp55R-infused animal 1 day after SE
T16188 23534-23541 Protein denotes TNFp55R
T16185 23534-23541 Entity denotes TNFp55R
T16192 23542-23550 Entity denotes infusion
T16209 23571-23581 Protein denotes p65-Thr435
T16179 23571-23581 Entity denotes p65-Thr435
T16186 23617-23623 Protein denotes GLUT-1
T16203 23624-23650 Entity denotes positive endothelial cells
T16187 23687-23690 Entity denotes E-G
T9852 23775-23782 Entity denotes antigen
T9840 23814-23826 Protein denotes the PC 1 day
T9847 23833-23839 Protein denotes SE [5]
T9836 23866-23868 Protein denotes SE
T9849 23964-23966 Protein denotes IV
T9845 23970-23976 Protein denotes the PC
T9841 24130-24132 Entity denotes SE
T9854 24178-24229 Phosphorylation denotes increased p65-Thr435 phosphorylation (Figures 5C-D)
T9853 24178-24229 Positive_regulation denotes increased p65-Thr435 phosphorylation (Figures 5C-D)
T9848 24188-24198 Protein denotes p65-Thr435
T9843 24188-24198 Entity denotes p65-Thr435
T9855 24280-24386 Phosphorylation denotes was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
T9839 24308-24318 Protein denotes p65-Thr435
T9835 24308-24318 Entity denotes p65-Thr435
T9838 24388-24389 Entity denotes p
T9844 24423-24440 Entity denotes sTNFp55R infusion
T9846 24424-24427 Protein denotes TNF
T9851 24464-24474 Protein denotes p65-Thr435
T9850 24464-24474 Entity denotes p65-Thr435
T9842 24532-24549 Entity denotes endothelial cells
T9837 24560-24562 Protein denotes SE
T9834 24579-24630 Entity denotes saline infusion (p < 0.05; Figures 4A-B, 5D and 5F)
T10341 24633-24643 Entity denotes Neutrophil
T10346 24691-24702 Entity denotes neutrophils
T10342 24801-24811 Entity denotes neutrophil
T10356 24838-24840 Protein denotes IV
T10350 24844-24870 Protein denotes the PC 1 day after SE [20]
T10362 24863-24870 Entity denotes SE [20]
T10351 24919-24929 Entity denotes the saline
T10358 24967-24970 Protein denotes MPO
T10344 24971-24991 Entity denotes positive neutrophils
T10355 24997-25003 Protein denotes the PC
T10357 25075-25085 Entity denotes neutrophil
T10361 25104-25137 Protein denotes the PC 1 day after SE (Figure 6A)
T10352 25123-25125 Entity denotes SE
T10347 25177-25179 Protein denotes PC
T10360 25264-25272 Entity denotes sTNFp55R
T10348 25264-25272 Protein denotes sTNFp55R
T10343 25410-25420 Entity denotes neutrophil
T10359 25541-25551 Entity denotes neutrophil
T10345 25736-25746 Entity denotes SE-induced
T10349 25747-25757 Entity denotes neutrophil
T10354 25776-25782 Protein denotes the PC
T10363 25801-25844 Regulation denotes to TNF-α-mediated vasogenic edema formation
T10353 25804-25818 Protein denotes TNF-α-mediated
T16809 25867-25870 Protein denotes TNF
T16797 25867-25944 Entity denotes TNFp55R infusion on neutrophil infiltration and MIP-2 expression following SE
T16814 25887-25897 Entity denotes neutrophil
T16800 25915-25920 Protein denotes MIP-2
T16816 25915-25931 Gene_expression denotes MIP-2 expression
T16793 25942-25944 Protein denotes SE
T16802 25950-25960 Entity denotes Neutrophil
T16804 26012-26014 Entity denotes SE
T16807 26020-26025 Protein denotes MIP-2
T16815 26020-26061 Gene_expression denotes MIP-2 expression in the PC 1 day after SE
T16799 26040-26052 Protein denotes the PC 1 day
T16803 26059-26061 Protein denotes SE
T16805 26067-26106 Protein denotes Astroglial expression of MIP-2 (arrows)
T16796 26175-26185 Entity denotes neutrophil
T16791 26211-26213 Entity denotes SE
T16806 26259-26265 Entity denotes saline
T16792 26333-26370 Entity denotes the number of infiltrated neutrophils
T16798 26441-26447 Protein denotes the PC
T16795 26489-26512 Entity denotes of MIP-2 positive cells
T16811 26492-26497 Protein denotes MIP-2
T16810 26562-26579 Entity denotes SE (mean ± S.E.M)
T16794 26621-26626 Protein denotes MIP-2
T16801 26627-26641 Entity denotes positive cells
T16808 26786-26809 Entity denotes of MIP-2 positive cells
T16813 26789-26794 Protein denotes MIP-2
T16812 26885-26891 Protein denotes the PC
T11256 26894-26899 Protein denotes MIP-2
T11273 26894-26910 Gene_expression denotes MIP-2 expression
T11241 26911-26916 Protein denotes MIP-2
T11260 26920-26992 Protein denotes a powerful chemokine that contributes to recruitment of neutrophils [27]
T11264 26976-26992 Entity denotes neutrophils [27]
T11246 26994-26999 Protein denotes MIP-2
T11268 27137-27142 Protein denotes TNF-α
T11247 27150-27172 Protein denotes interleukin-1β (IL-1β)
T11263 27166-27171 Protein denotes IL-1β
T11270 27233-27247 Protein denotes TNF-α-mediated
T11276 27233-27264 Gene_expression denotes TNF-α-mediated MIP-2 expression
T11272 27233-27264 Regulation denotes TNF-α-mediated MIP-2 expression
T11259 27248-27253 Protein denotes MIP-2
T11244 27277-27279 Entity denotes SE
T11252 27288-27298 Entity denotes neutrophil
T11274 27314-27384 Gene_expression denotes To confirm this hypothesis, we investigated MIP-2 expression in the PC
T11240 27358-27363 Protein denotes MIP-2
T11253 27378-27384 Protein denotes the PC
T11250 27427-27457 Entity denotes some MIP-2-positive astrocytes
T11269 27475-27483 Entity denotes the core
T11255 27612-27635 Entity denotes of MIP-2 positive cells
T11267 27615-27620 Protein denotes MIP-2
T11257 27657-27659 Protein denotes PC
T11251 27844-27867 Entity denotes of MIP-2 positive cells
T11271 27847-27852 Protein denotes MIP-2
T11266 28001-28006 Protein denotes MIP-2
T11243 28007-28021 Entity denotes positive cells
T11261 28196-28206 Entity denotes neutrophil
T11254 28227-28229 Protein denotes PC
T11262 28296-28306 Protein denotes that TNF-α
T11249 28320-28330 Entity denotes SE-induced
T11245 28331-28341 Entity denotes neutrophil
T11242 28367-28373 Protein denotes the PC
T11265 28416-28437 Protein denotes direct TNF-α-mediated
T11277 28416-28468 Regulation denotes direct TNF-α-mediated MIP-2 expression in astrocytes
T11275 28416-28468 Gene_expression denotes direct TNF-α-mediated MIP-2 expression in astrocytes
T11258 28438-28443 Protein denotes MIP-2
T11248 28458-28468 Entity denotes astrocytes
T14368 28531-28536 Protein denotes TNF-α
T14402 28531-28546 Positive_regulation denotes TNF-α signaling
T14374 28585-28590 Protein denotes NF-κB
T14403 28585-28606 Phosphorylation denotes NF-κB phosphorylation
T14375 28610-28616 Entity denotes the PC
T14273 28627-28629 Entity denotes SE
T14335 28693-28703 Entity denotes neutrophil
T14258 28845-28868 Entity denotes the extracellular space
T14263 29086-29091 Protein denotes TNF-α
T14303 29135-29167 Entity denotes microglia in the PC following SE
T14315 29148-29167 Protein denotes the PC following SE
T14378 29165-29167 Protein denotes SE
T14276 29169-29172 Protein denotes TNF
T14278 29169-29193 Protein denotes TNF receptor expressions
T14376 29220-29252 Entity denotes astrocytes (TNFp55R and TNFp75R)
T14381 29257-29284 Entity denotes endothelial cells (TNFp75R)
T14337 29276-29283 Protein denotes TNFp75R
T14400 29308-29326 Positive_regulation denotes of TNF-α signaling
T14287 29311-29316 Protein denotes TNF-α
T14312 29327-29346 Entity denotes by sTNFp55 infusion
T14325 29399-29409 Entity denotes SE-induced
T14354 29449-29455 Protein denotes the PC
T14350 29486-29491 Protein denotes TNF-α
T14299 29551-29554 Entity denotes SE,
T14261 29577-29587 Entity denotes SE-induced
T14314 29629-29634 Protein denotes TNF-α
T14405 29629-29644 Positive_regulation denotes TNF-α signaling
T14301 29739-29755 Entity denotes sTNFp55 infusion
T14389 29785-29795 Entity denotes SE-induced
T14280 29835-29841 Protein denotes the PC
T14328 29880-29885 Protein denotes TNF-α
T14409 29880-29895 Positive_regulation denotes TNF-α signaling
T14327 29963-29966 Protein denotes p65
T14398 29963-29991 Phosphorylation denotes p65 phosphorylation of NF-κB
T14275 29983-29991 Protein denotes of NF-κB
T14290 30036-30039 Protein denotes p65
T14412 30036-30055 Phosphorylation denotes p65 phosphorylation
T14336 30073-30086 Entity denotes the cytoplasm
T14297 30090-30106 Entity denotes the nucleus [30]
T14292 30130-30140 Entity denotes p65-Thr435
T14361 30130-30140 Protein denotes p65-Thr435
T14386 30134-30140 Entity denotes Thr435
T14334 30174-30191 Entity denotes endothelial cells
T14342 30315-30323 Entity denotes antigen,
T14310 30327-30383 Protein denotes a protein expressed by endothelial cells of rat BBB [31]
T14410 30327-30383 Gene_expression denotes a protein expressed by endothelial cells of rat BBB [31]
T14266 30347-30383 Entity denotes by endothelial cells of rat BBB [31]
T14330 30445-30476 Entity denotes endothelial cells [5,7,8,30,32]
T14366 30666-30718 Entity denotes of intercellular junctions between endothelial cells
T14358 30701-30718 Entity denotes endothelial cells
T14370 30811-30827 Entity denotes endothelial cell
T14298 30948-30950 Entity denotes SE
T14329 31020-31037 Entity denotes sTNFp55R infusion
T14284 31021-31024 Protein denotes TNF
T14293 31060-31070 Entity denotes SE-induced
T14395 31111-31159 Phosphorylation denotes the phosphorylation of p65-Thr435 by TNF-α [39],
T14300 31131-31144 Protein denotes of p65-Thr435
T14371 31131-31144 Entity denotes of p65-Thr435
T14352 31145-31158 Protein denotes by TNF-α [39]
T14268 31187-31201 Protein denotes TNF-α-mediated
T14406 31187-31249 Regulation denotes TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
T14291 31202-31212 Protein denotes p65-Thr435
T14347 31202-31212 Entity denotes p65-Thr435
T14388 31232-31249 Entity denotes endothelial cells
T14365 31427-31469 Protein denotes dystrophin (an actin-binding protein [40])
T14295 31439-31468 Protein denotes an actin-binding protein [40]
T14279 31566-31587 Protein denotes down-regulated 12 hrs
T14408 31566-31587 Negative_regulation denotes down-regulated 12 hrs
T14355 31594-31596 Protein denotes SE
T14269 31805-31822 Entity denotes endothelial cells
T14379 31827-31850 Entity denotes perivascular astrocytes
T14346 31874-31877 Protein denotes p65
T14307 31878-31884 Entity denotes Ser276
T14321 31886-31889 Protein denotes p65
T14294 31890-31896 Entity denotes Ser311
T14391 31898-31901 Protein denotes p65
T14377 31902-31908 Entity denotes Ser529
T14383 31914-31924 Entity denotes p65-Ser536
T14356 31914-31924 Protein denotes p65-Ser536
T14397 31914-31980 Phosphorylation denotes p65-Ser536 phosphorylation was observed in astrocytes following SE
T14344 31957-31980 Entity denotes astrocytes following SE
T14364 31978-31980 Protein denotes SE
T14304 31995-32012 Entity denotes sTNFp55R infusion
T14349 31996-31999 Protein denotes TNF
T14267 32035-32045 Protein denotes p65-Ser276
T14384 32035-32045 Entity denotes p65-Ser276
T14351 32079-32089 Entity denotes astrocytes
T14309 32100-32102 Protein denotes SE
T14399 32133-32152 Positive_regulation denotes enhanced p65-Ser276
T14360 32133-32152 Protein denotes enhanced p65-Ser276
T14340 32133-32152 Entity denotes enhanced p65-Ser276
T14380 32157-32167 Protein denotes p65-Ser311
T14369 32157-32167 Entity denotes p65-Ser311
T14413 32157-32183 Phosphorylation denotes p65-Ser311 phosphorylation
T14296 32203-32208 Protein denotes TNF-α
T14353 32243-32260 Entity denotes sTNFp55R infusion
T14390 32244-32247 Protein denotes TNF
T14289 32279-32289 Entity denotes p65-Ser529
T14363 32279-32289 Protein denotes p65-Ser529
T14332 32294-32321 Entity denotes p65-Ser536 phosphorylations
T14373 32294-32321 Protein denotes p65-Ser536 phosphorylations
T14331 32327-32329 Entity denotes SE
T14359 32345-32355 Protein denotes p65-Ser529
T14345 32345-32355 Entity denotes p65-Ser529
T14302 32360-32370 Entity denotes p65-Ser536
T14382 32360-32370 Protein denotes p65-Ser536
T14318 32393-32398 Protein denotes TNF-α
T14324 32403-32414 Protein denotes IL-1β [41],
T14272 32433-32447 Protein denotes IL-1β-mediated
T14357 32506-32516 Entity denotes SE-induced
T14322 32577-32582 Protein denotes TNF-α
T14281 32587-32592 Protein denotes IL-1β
T14372 32600-32618 Entity denotes synergists to play
T14316 32639-32656 Entity denotes endothelial cells
T14306 32674-32684 Entity denotes astrocytes
T14323 32731-32741 Entity denotes Neutrophil
T14271 32824-32829 Protein denotes of SE
T14333 32847-32849 Entity denotes SE
T14311 32883-32885 Entity denotes SE
T14288 32929-32939 Protein denotes chemokines
T14313 32995-33000 Protein denotes MIP-2
T14264 33017-33037 Entity denotes efficient neutrophil
T14282 33041-33051 Entity denotes lymphocyte
T14411 33041-33088 Binding denotes lymphocyte recruitment to brain parenchyma [43]
T14262 33118-33128 Entity denotes neutrophil
T14404 33185-33227 Gene_expression denotes by P2X7 receptor-mediated MIP-2 expression
T14401 33185-33227 Regulation denotes by P2X7 receptor-mediated MIP-2 expression
T14317 33188-33192 Protein denotes P2X7
T14285 33193-33210 Protein denotes receptor-mediated
T14270 33211-33216 Protein denotes MIP-2
T14343 33232-33239 Protein denotes the PC,
T14394 33273-33291 Entity denotes agonist/antagonist
T14348 33273-33291 Entity denotes agonist/antagonist
T14341 33281-33291 Entity denotes antagonist
T14362 33296-33324 Protein denotes IL-1Ra (an IL-1β antagonist)
T14393 33296-33333 Entity denotes IL-1Ra (an IL-1β antagonist) infusion
T14319 33304-33323 Protein denotes an IL-1β antagonist
T14392 33351-33360 Entity denotes leukocyte
T14326 33398-33405 Entity denotes TNFp55R
T14367 33398-33405 Protein denotes TNFp55R
T14260 33406-33414 Entity denotes infusion
T14283 33437-33447 Entity denotes neutrophil
T14274 33464-33470 Protein denotes the PC
T14407 33474-33538 Negative_regulation denotes reducing vasogenic edema formation in a MIP-2-independent manner
T14339 33514-33531 Protein denotes MIP-2-independent
T14338 33646-33654 Protein denotes by TNF-α
T14286 33666-33676 Entity denotes neutrophil
T14387 33744-33751 Protein denotes the PC,
T14308 33835-33851 Entity denotes endothelial cell
T14320 33865-33879 Protein denotes TNF-α mediated
T14414 33865-33879 Regulation denotes TNF-α mediated
T14265 33865-33913 Protein denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14259 33865-33913 Entity denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14396 33865-33913 Phosphorylation denotes TNF-α mediated p65-Thr 435 NF-κB phosphorylation
T14305 33892-33897 Protein denotes NF-κB
T14385 33933-33935 Entity denotes SE
T14277 33982-33992 Entity denotes neutrophil
R11186 T14259 T14305 partOf TNF-α mediated p65-Thr 435 NF-κB phosphorylation,NF-κB
R11187 T14259 T14396 siteOf TNF-α mediated p65-Thr 435 NF-κB phosphorylation,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11189 T14268 T14406 causeOf TNF-α-mediated,TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells
R11192 T14270 T14404 themeOf MIP-2,by P2X7 receptor-mediated MIP-2 expression
R11195 T14275 T14398 themeOf of NF-κB,p65 phosphorylation of NF-κB
R11196 T14279 T14408 themeOf down-regulated 12 hrs,down-regulated 12 hrs
R11197 T14285 T14401 causeOf receptor-mediated,by P2X7 receptor-mediated MIP-2 expression
R11198 T14287 T14400 causeOf TNF-α,of TNF-α signaling
R11199 T14290 T14412 themeOf p65,p65 phosphorylation
R11200 T14380 T14413 themeOf p65-Ser311,p65-Ser311 phosphorylation
R11201 T14383 T14356 partOf p65-Ser536,p65-Ser536
R11202 T14383 T14397 siteOf p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11203 T14300 T14395 themeOf of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11204 T14305 T14396 themeOf NF-κB,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11205 T14310 T14410 themeOf a protein expressed by endothelial cells of rat BBB [31],a protein expressed by endothelial cells of rat BBB [31]
R11206 T14404 T14401 themeOf by P2X7 receptor-mediated MIP-2 expression,by P2X7 receptor-mediated MIP-2 expression
R11207 T14314 T14405 causeOf TNF-α,TNF-α signaling
R11208 T14320 T14396 causeOf TNF-α mediated,TNF-α mediated p65-Thr 435 NF-κB phosphorylation
R11209 T14320 T14414 themeOf TNF-α mediated,TNF-α mediated
R11210 T14327 T14398 causeOf p65,p65 phosphorylation of NF-κB
R11211 T14328 T14409 causeOf TNF-α,TNF-α signaling
R11212 T14352 T14395 causeOf by TNF-α [39],"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11213 T14356 T14397 themeOf p65-Ser536,p65-Ser536 phosphorylation was observed in astrocytes following SE
R11214 T14360 T14399 themeOf enhanced p65-Ser276,enhanced p65-Ser276
R11215 T14368 T14402 causeOf TNF-α,TNF-α signaling
R11216 T14369 T14380 partOf p65-Ser311,p65-Ser311
R11217 T14369 T14413 siteOf p65-Ser311,p65-Ser311 phosphorylation
R11218 T14371 T14300 partOf of p65-Thr435,of p65-Thr435
R11219 T14371 T14395 siteOf of p65-Thr435,"the phosphorylation of p65-Thr435 by TNF-α [39],"
R11220 T14374 T14403 themeOf NF-κB,NF-κB phosphorylation
R11360 T14671 T14686 themeOf TNF receptor,Expression of TNF-α and TNF receptor in the PC 12 hr-post
R11361 T14674 T14685 themeOf TNF-α,Expression of TNF-α and TNF receptor in the PC 12 hr-post
R11362 T14675 T14683 themeOf TNFp75R,TNFp75R expression in astrocytes as well as endothelial cells (arrows)
R11363 T14682 T14684 themeOf TNFp55R,TNFp55R expression in astrocytes (arrows)
R11906 T15414 T15433 themeOf p65-Ser536 (H),p65-Ser536 (H) phosphorylation
R11907 T15421 T15435 themeOf p65-Ser536 (G),p65-Ser536 (G) phosphorylation
R11908 T15423 T15434 themeOf NF-κB,on NF-κB phosphorylation in astrocytes
R11909 T15426 T15421 partOf p65-Ser536 (G),p65-Ser536 (G)
R11910 T15426 T15435 siteOf p65-Ser536 (G),p65-Ser536 (G) phosphorylation
R11911 T15432 T15414 partOf p65-Ser536 (H),p65-Ser536 (H)
R11912 T15432 T15433 siteOf p65-Ser536 (H),p65-Ser536 (H) phosphorylation
R12099 T15681 T15692 themeOf p65-Thr435,p65-Thr435 phosphorylation
R12100 T15682 T15693 themeOf NF-κB,NF-κB phosphorylation
R12101 T15683 T15681 partOf p65-Thr435,p65-Thr435
R12102 T15683 T15692 siteOf p65-Thr435,p65-Thr435 phosphorylation
R12103 T15689 T15694 themeOf NF-κB,of NF-κB phosphorylation 12 hr after SE (mean ± S.E.M)
R12364 T16182 T16189 partOf p65-Thr435,p65-Thr435
R12365 T16182 T16218 siteOf p65-Thr435,of p65-Thr435 phosphorylation
R12366 T16184 T16202 partOf p65-Thr435,p65-Thr435
R12367 T16184 T16219 siteOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
R12368 T16189 T16218 themeOf p65-Thr435,of p65-Thr435 phosphorylation
R12369 T16194 T16214 themeOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
R12370 T16196 T16199 partOf p65-Thr435,p65-Thr435
R12371 T16196 T16216 siteOf p65-Thr435,p65-Thr435 phosphorylation
R12372 T16197 T16217 themeOf p65-Thr435,p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
R12373 T16199 T16216 themeOf p65-Thr435,p65-Thr435 phosphorylation
R12374 T16201 T16194 partOf p65-Thr435,p65-Thr435
R12375 T16201 T16214 siteOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in sTNFp55R-infused animal 1 day after SE
R12376 T16202 T16219 themeOf p65-Thr435,Endothelial p65-Thr435 phosphorylation in saline-infused animals 1 day after SE
R12377 T16206 T16215 themeOf Endothelial p65-Thr435 phosphorylation in non-SE animals,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12378 T16207 T16206 partOf Thr435,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12379 T16207 T16215 siteOf Thr435,Endothelial p65-Thr435 phosphorylation in non-SE animals
R12380 T16212 T16197 partOf p65-Thr435,p65-Thr435
R12381 T16212 T16217 siteOf p65-Thr435,p65-Thr435 phosphorylation is rarely observed in astrocytes (arrows)
R12382 T16216 T16213 themeOf p65-Thr435 phosphorylation,p65-Thr435 phosphorylation is enhanced
R12823 T16800 T16816 themeOf MIP-2,MIP-2 expression
R12824 T16807 T16815 themeOf MIP-2,MIP-2 expression in the PC 1 day after SE
R2144 T2861 T2936 themeOf MIP-2,mediated MIP-2 expression
R2145 T2874 T2935 causeOf TNF-α,TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2152 T2912 T2934 themeOf macrophage inflammatory protein-2 (MIP-2),TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2154 T2936 T2933 themeOf mediated MIP-2 expression,mediated MIP-2 expression
R2155 T2912 T2935 themeOf macrophage inflammatory protein-2 (MIP-2),TNF-α induces macrophage inflammatory protein-2 (MIP-2)
R2156 T2918 T2932 themeOf MIP-2,"Neurons, microglia, and astrocytes produce MIP-2 when incubated with pro-inflammatory cytokines such as TNF-α"
R3027 T3917 T3934 themeOf divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor,divided into two groups: vehicle (saline)-treated and soluble TNFp55 receptor
R600 T964 T983 themeOf TNF p75 receptor,TNF p75 receptor expression
R601 T966 T989 causeOf by pilocarpine,"SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-,"
R602 T973 T990 themeOf NF-κB,TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
R603 T976 T973 partOf TNF-α-mediated p65-Thr 485 NF-κB phosphorylation,NF-κB
R604 T976 T990 siteOf TNF-α-mediated p65-Thr 485 NF-κB phosphorylation,TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
R605 T985 T986 themeOf only p65-Thr435 phosphorylation,only p65-Thr435 phosphorylation was increased
R606 T990 T984 themeOf TNF-α-mediated p65-Thr 485 NF-κB phosphorylation,TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
R653 T933 T988 themeOf SE,"SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-,"
R654 T933 T989 themeOf SE,"SE was induced by pilocarpine in rats that were intracerebroventricularly infused with saline-,"
R655 T935 T987 causeOf Tumor necrosis factor-α,Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells
R656 T939 T943 partOf p65-Thr435,p65-Thr435
R657 T939 T985 siteOf p65-Thr435,only p65-Thr435 phosphorylation
R658 T943 T985 themeOf p65-Thr435,only p65-Thr435 phosphorylation
R659 T956 T984 causeOf TNF-α-mediated,TNF-α-mediated p65-Thr 485 NF-κB phosphorylation
R6898 T8277 T8304 themeOf "TNF-α, and TNF receptor","TNF-α, and TNF receptor expression"
R7597 T9296 T9307 partOf p65-Ser311,p65-Ser311
R7598 T9296 T9338 siteOf p65-Ser311,p65-Ser311 phosphorylation
R7599 T9298 T9337 themeOf p65-Thr435,p65-Thr435 phosphorylation
R7600 T9306 T9342 themeOf NF-κB,NF-κB phosphorylation
R7601 T9307 T9338 themeOf p65-Ser311,p65-Ser311 phosphorylation
R7602 T9313 T9341 themeOf p65-Ser536,p65-Ser536 phosphorylation
R7603 T9314 T9327 partOf p65-Ser536,p65-Ser536
R7604 T9314 T9340 siteOf p65-Ser536,p65-Ser536 phosphorylation
R7605 T9321 T9298 partOf p65-Thr435,p65-Thr435
R7606 T9321 T9337 siteOf p65-Thr435,p65-Thr435 phosphorylation
R7607 T9323 T9313 partOf p65-Ser536,p65-Ser536
R7608 T9323 T9341 siteOf p65-Ser536,p65-Ser536 phosphorylation
R7609 T9327 T9340 themeOf p65-Ser536,p65-Ser536 phosphorylation
R7610 T9331 T9339 themeOf of NF-κB,phosphorylation of NF-κB
R7611 T9337 T9336 themeOf p65-Thr435 phosphorylation,"In contrast, p65-Thr435 phosphorylation was increased in endothelial cells"
R7991 T9835 T9839 partOf p65-Thr435,p65-Thr435
R7992 T9835 T9855 siteOf p65-Thr435,was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
R7993 T9839 T9855 themeOf p65-Thr435,was inversely correlated to p65-Thr435 phosphorylation with a linear coefficient of correlation of -0.6324
R7994 T9843 T9848 partOf p65-Thr435,p65-Thr435
R7995 T9843 T9854 siteOf p65-Thr435,increased p65-Thr435 phosphorylation (Figures 5C-D)
R7996 T9848 T9854 themeOf p65-Thr435,increased p65-Thr435 phosphorylation (Figures 5C-D)
R7997 T9854 T9853 themeOf increased p65-Thr435 phosphorylation (Figures 5C-D),increased p65-Thr435 phosphorylation (Figures 5C-D)
R8401 T10353 T10363 causeOf TNF-α-mediated,to TNF-α-mediated vasogenic edema formation
R9028 T11240 T11274 themeOf MIP-2,"To confirm this hypothesis, we investigated MIP-2 expression in the PC"
R9029 T11256 T11273 themeOf MIP-2,MIP-2 expression
R9030 T11258 T11275 themeOf MIP-2,direct TNF-α-mediated MIP-2 expression in astrocytes
R9031 T11259 T11276 themeOf MIP-2,TNF-α-mediated MIP-2 expression
R9032 T11265 T11277 causeOf direct TNF-α-mediated,direct TNF-α-mediated MIP-2 expression in astrocytes
R9033 T11270 T11272 causeOf TNF-α-mediated,TNF-α-mediated MIP-2 expression
R9034 T11275 T11277 themeOf direct TNF-α-mediated MIP-2 expression in astrocytes,direct TNF-α-mediated MIP-2 expression in astrocytes
R9035 T11276 T11272 themeOf TNF-α-mediated MIP-2 expression,TNF-α-mediated MIP-2 expression