Id |
Subject |
Object |
Predicate |
Lexical cue |
Speculation |
T21854 |
19-52 |
Gene_expression |
denotes |
anti-CD3-induced IL-17 production |
|
T21666 |
36-41 |
Protein |
denotes |
IL-17 |
|
T21779 |
56-58 |
Protein |
denotes |
RA |
|
T21652 |
56-63 |
Entity |
denotes |
RA PBMC |
|
T21726 |
94-121 |
Entity |
denotes |
the PI3K inhibitor LY294002 |
|
T21668 |
94-121 |
Entity |
denotes |
the PI3K inhibitor LY294002 |
|
T21760 |
98-102 |
Protein |
denotes |
PI3K |
|
T21639 |
126-145 |
Entity |
denotes |
the NF-κB inhibitor |
|
T21814 |
213-299 |
Negative_regulation |
denotes |
We also found that anti-CD3-induced IL-17 production was downregulated by the addition |
|
T21840 |
227-299 |
Positive_regulation |
denotes |
that anti-CD3-induced IL-17 production was downregulated by the addition |
|
T21700 |
232-248 |
Protein |
denotes |
anti-CD3-induced |
|
T21835 |
232-265 |
Gene_expression |
denotes |
anti-CD3-induced IL-17 production |
|
T21793 |
249-254 |
Protein |
denotes |
IL-17 |
|
T21790 |
315-318 |
Protein |
denotes |
p38 |
|
T21762 |
315-333 |
Entity |
denotes |
p38 MAPK inhibitor |
|
T21727 |
315-333 |
Protein |
denotes |
p38 MAPK inhibitor |
|
T21794 |
406-411 |
Protein |
denotes |
NF-κB |
|
T21802 |
416-419 |
Protein |
denotes |
p38 |
|
T21844 |
421-471 |
Positive_regulation |
denotes |
In myocytes, IκB kinase-β is activated by p38 [32] |
|
T21622 |
424-432 |
Entity |
denotes |
myocytes |
|
T21689 |
434-446 |
Protein |
denotes |
IκB kinase-β |
|
T21789 |
460-471 |
Protein |
denotes |
by p38 [32] |
|
T21815 |
477-494 |
Positive_regulation |
denotes |
the activated p38 |
|
T21645 |
477-494 |
Protein |
denotes |
the activated p38 |
|
T21860 |
477-588 |
Positive_regulation |
denotes |
the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33] |
true |
T21730 |
509-588 |
Protein |
denotes |
NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33] |
|
T21691 |
540-547 |
Entity |
denotes |
histone |
|
T21667 |
540-588 |
Protein |
denotes |
histone acetylase p300/CREB-binding protein [33] |
|
T21805 |
558-583 |
Protein |
denotes |
p300/CREB-binding protein |
|
T21735 |
558-583 |
Protein |
denotes |
p300/CREB-binding protein |
|
T21694 |
563-583 |
Protein |
denotes |
CREB-binding protein |
|
T21686 |
616-619 |
Protein |
denotes |
p38 |
|
T21791 |
616-635 |
Protein |
denotes |
p38 MAPK activation |
|
T21823 |
616-665 |
Regulation |
denotes |
p38 MAPK activation was not affected by LY294002, |
|
T21661 |
653-665 |
Entity |
denotes |
by LY294002, |
|
T21740 |
711-723 |
Entity |
denotes |
by LY294002, |
|
T21755 |
756-805 |
Protein |
denotes |
a p38 MAPK pathway independent of PI3K activation |
|
T21715 |
756-805 |
Protein |
denotes |
a p38 MAPK pathway independent of PI3K activation |
|
T21813 |
787-805 |
Positive_regulation |
denotes |
of PI3K activation |
|
T21679 |
790-794 |
Protein |
denotes |
PI3K |
|
T21623 |
839-842 |
Protein |
denotes |
p38 |
|
T21633 |
847-852 |
Protein |
denotes |
NF-κB |
|
T21681 |
857-862 |
Protein |
denotes |
IL-17 |
|
T21861 |
857-873 |
Gene_expression |
denotes |
IL-17 production |
|
R11938 |
T21645 |
T21815 |
themeOf |
the activated p38,the activated p38 |
R11941 |
T21661 |
T21823 |
causeOf |
"by LY294002,","p38 MAPK activation was not affected by LY294002," |
R11942 |
T21666 |
T21854 |
themeOf |
IL-17,anti-CD3-induced IL-17 production |
R11953 |
T21679 |
T21813 |
themeOf |
PI3K,of PI3K activation |
R11959 |
T21681 |
T21861 |
themeOf |
IL-17,IL-17 production |
R11963 |
T21789 |
T21844 |
causeOf |
by p38 [32],"In myocytes, IκB kinase-β is activated by p38 [32]" |
R11966 |
T21793 |
T21835 |
themeOf |
IL-17,anti-CD3-induced IL-17 production |
R11969 |
T21689 |
T21844 |
themeOf |
IκB kinase-β,"In myocytes, IκB kinase-β is activated by p38 [32]" |
R11983 |
T21835 |
T21814 |
themeOf |
anti-CD3-induced IL-17 production,We also found that anti-CD3-induced IL-17 production was downregulated by the addition |
R11984 |
T21835 |
T21840 |
themeOf |
anti-CD3-induced IL-17 production,that anti-CD3-induced IL-17 production was downregulated by the addition |
R11990 |
T21730 |
T21860 |
themeOf |
NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33],the activated p38 can stimulate NF-κB by a mechanism involving histone acetylase p300/CREB-binding protein [33] |