bionlp-st-ge-2016-test-ihmc  

PMC:1064873 JSONTXT 34 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Negation Speculation
T1896 14-19 Protein denotes IL-10
T1908 66-121 Gene_expression denotes expression of suppressor of cytokine signaling 1 in CD4
T1900 77-114 Protein denotes of suppressor of cytokine signaling 1
T1880 118-121 Protein denotes CD4
T1887 123-130 Entity denotes T cells
T1870 181-186 Protein denotes IL-10
T1871 211-256 Protein denotes the antigen-specific T-cell cytokine response
T1907 211-257 Localization denotes the antigen-specific T-cell cytokine response
T1905 215-231 Entity denotes antigen-specific
T1881 232-238 Entity denotes T-cell
T1893 275-279 Protein denotes CD28
T1866 330-333 Protein denotes CD4
T1903 335-394 Entity denotes T cells from patients with active rheumatoid arthritis (RA)
T1868 391-393 Protein denotes RA
T1886 435-445 Protein denotes interferon
T1891 458-461 Protein denotes CD3
T1885 466-470 Protein denotes CD28
T1906 466-484 Positive_regulation denotes CD28 costimulation
T1859 504-517 Protein denotes 1 ng/ml IL-10
T1875 543-546 Protein denotes CD4
T1889 548-555 Entity denotes T cells
T1904 591-619 Protein denotes of the type 1 IL-10 receptor
T1867 591-619 Protein denotes of the type 1 IL-10 receptor
T1894 605-610 Protein denotes IL-10
T1910 635-708 Phosphorylation denotes The phosphorylation of signal transducer and activator of transcription 3
T1902 655-708 Protein denotes of signal transducer and activator of transcription 3
T1860 757-776 Entity denotes CD4+ T cells of RA,
T1861 773-775 Protein denotes RA
T1883 818-834 Protein denotes of 1 ng/ml IL-10
T1879 836-857 Protein denotes Sera from RA patients
T1892 846-848 Protein denotes RA
T1876 866-916 Protein denotes signal transducer and activator of transcription 3
T1914 866-955 Phosphorylation denotes signal transducer and activator of transcription 3 phosphorylation in normal CD4+ T cells
T1877 936-955 Entity denotes normal CD4+ T cells
T1912 987-1018 Regulation denotes neutralizing anti-IL-6 antibody
T1884 1000-1018 Protein denotes anti-IL-6 antibody
T1901 1034-1047 Protein denotes of normal CD4
T1872 1049-1066 Entity denotes T cells with IL-6
T1918 1049-1131 Negative_regulation denotes T cells with IL-6 reduced IL-10-mediated inhibition of interferon gamma production
T1874 1062-1066 Protein denotes IL-6
T1873 1075-1089 Protein denotes IL-10-mediated
T1911 1075-1131 Regulation denotes IL-10-mediated inhibition of interferon gamma production
T1898 1139-1151 Entity denotes CD4+ T cells
T1869 1157-1159 Protein denotes RA
T1890 1196-1230 Protein denotes suppressor of cytokine signaling 1
T1862 1251-1285 Protein denotes suppressor of cytokine signaling 3
T1899 1251-1325 Protein denotes suppressor of cytokine signaling 3 mRNA compared with control CD4+ T cells
T1882 1300-1325 Entity denotes with control CD4+ T cells
T1865 1341-1357 Protein denotes by real-time PCR
T1888 1387-1389 Protein denotes RA
T1863 1387-1402 Entity denotes RA CD4+ T cells
T1864 1452-1460 Protein denotes of IL-10
T1909 1504-1533 Positive_regulation denotes this impaired IL-10 signaling
T1915 1504-1533 Negative_regulation denotes this impaired IL-10 signaling
T1878 1518-1523 Protein denotes IL-10
T1913 1557-1628 Positive_regulation denotes sustained signal transducer and activator of transcription 3 activation
T1897 1567-1617 Protein denotes signal transducer and activator of transcription 3
T1895 1633-1667 Protein denotes suppressor of cytokine signaling 1
T1916 1633-1677 Gene_expression denotes suppressor of cytokine signaling 1 induction
T1917 1633-1677 Positive_regulation denotes suppressor of cytokine signaling 1 induction
T6289 1693-1698 Protein denotes IL-10
T6225 1702-1716 Protein denotes a key cytokine
T6186 1804-1832 Protein denotes of proinflammatory cytokines
T6322 1834-1839 Protein denotes IL-10
T6346 1834-1884 Binding denotes IL-10 binds to the IL-10 receptor (IL-10R) complex
T6274 1846-1884 Protein denotes to the IL-10 receptor (IL-10R) complex
T6306 1846-1884 Entity denotes to the IL-10 receptor (IL-10R) complex
T6297 1869-1875 Protein denotes IL-10R
T6349 1919-1979 Binding denotes the primary ligand-binding component type 1 IL-10R (IL-10R1)
T6167 1919-1979 Entity denotes the primary ligand-binding component type 1 IL-10R (IL-10R1)
T6304 1946-1979 Protein denotes component type 1 IL-10R (IL-10R1)
T6171 1971-1978 Protein denotes IL-10R1
T6178 1984-2021 Protein denotes the accessory component type 2 IL-10R
T6354 2027-2062 Binding denotes The interaction of IL-10 and IL-10R
T6215 2046-2051 Protein denotes IL-10
T6219 2056-2062 Protein denotes IL-10R
T6246 2071-2122 Protein denotes the Janus kinase (JAK) family tyrosine kinases Jak1
T6169 2071-2122 Protein denotes the Janus kinase (JAK) family tyrosine kinases Jak1
T6198 2075-2080 Protein denotes Janus
T6227 2081-2093 Protein denotes kinase (JAK)
T6259 2089-2092 Protein denotes JAK
T6230 2101-2109 Entity denotes tyrosine
T6330 2127-2131 Protein denotes Tyk2
T6355 2133-2199 Binding denotes which are constitutively associated with IL-10R1 and type 2 IL-10R
T6356 2133-2199 Binding denotes which are constitutively associated with IL-10R1 and type 2 IL-10R
T6208 2174-2181 Protein denotes IL-10R1
T6234 2186-2199 Protein denotes type 2 IL-10R
T6256 2219-2224 Protein denotes IL-10
T6263 2233-2257 Entity denotes tyrosine phosphorylation
T6374 2262-2368 Positive_regulation denotes activation of the latent transcriptional factors signal transducer and activator of transcription (STAT) 3
T6216 2273-2368 Protein denotes of the latent transcriptional factors signal transducer and activator of transcription (STAT) 3
T6283 2373-2382 Protein denotes STAT1 [3]
T6250 2406-2411 Protein denotes STAT1
T6345 2406-2533 Regulation denotes STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription
T6344 2406-2533 Regulation denotes STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription
T6272 2416-2421 Protein denotes STAT3
T6311 2416-2430 Protein denotes STAT3 proteins
T6168 2436-2446 Entity denotes homodimers
T6188 2450-2501 Entity denotes heterodimers, rapidly translocate into the nucleus,
T6241 2489-2500 Entity denotes the nucleus
T6199 2515-2519 Protein denotes gene
T6347 2515-2533 Transcription denotes gene transcription
T6190 2549-2554 Protein denotes STAT3
T6307 2581-2594 Protein denotes IL-10-derived
T6313 2581-2612 Entity denotes IL-10-derived anti-inflammatory
T6228 2617-2629 Protein denotes IL-6-derived
T6295 2669-2696 Protein denotes of cell-type-specific STAT3
T6298 2707-2711 Protein denotes mice
T6369 2717-2744 Positive_regulation denotes shown that STAT3 activation
T6191 2728-2733 Protein denotes STAT3
T6282 2762-2776 Protein denotes IL-10-mediated
T6317 2762-2840 Entity denotes IL-10-mediated anti-inflammatory reactions in macrophages and neutrophils [5],
T6294 2808-2819 Entity denotes macrophages
T6316 2824-2835 Entity denotes neutrophils
T6372 2848-2901 Regulation denotes responsible for IL-6-mediated prevention of apoptosis
T6267 2864-2877 Protein denotes IL-6-mediated
T6336 2905-2916 Entity denotes T cells [6]
T6275 2918-2961 Protein denotes The suppressor of cytokine signaling (SOCS)
T6232 2956-2960 Protein denotes SOCS
T6326 2962-2970 Protein denotes proteins
T6224 3007-3039 Protein denotes endogenous JAK kinase inhibitors
T6321 3007-3039 Entity denotes endogenous JAK kinase inhibitors
T6310 3007-3039 Protein denotes endogenous JAK kinase inhibitors
T6211 3018-3021 Protein denotes JAK
T6231 3160-3187 Protein denotes cytokine signaling pathways
T6213 3242-3247 Protein denotes SOCS3
T6286 3303-3308 Protein denotes IL-10
T6249 3313-3317 Protein denotes IL-6
T6341 3319-3406 Negative_regulation denotes by specifically blocking STAT3 activation induced by IL-6 but not that induced by IL-10
T6221 3344-3349 Protein denotes STAT3
T6353 3344-3406 Positive_regulation denotes STAT3 activation induced by IL-6 but not that induced by IL-10
T6279 3369-3376 Protein denotes by IL-6
T6176 3398-3406 Protein denotes by IL-10
T6164 3461-3463 Protein denotes RA
T6212 3512-3533 Entity denotes of inflammatory cells
T6287 3543-3554 Entity denotes lymphocytes
T6315 3556-3567 Entity denotes macrophages
T6237 3573-3588 Entity denotes dendritic cells
T6182 3630-3651 Entity denotes fibroblast-like cells
T6202 3630-3651 Entity denotes fibroblast-like cells
T6296 3641-3651 Entity denotes like cells
T6235 3653-3671 Protein denotes Numerous cytokines
T6359 3653-3710 Gene_expression denotes Numerous cytokines are overproduced in the inflamed joint
T6358 3653-3710 Positive_regulation denotes Numerous cytokines are overproduced in the inflamed joint
T6327 3716-3727 Entity denotes macrophages
T6175 3732-3752 Entity denotes synovial fibroblasts
T6331 3777-3805 Protein denotes of proinflammatory cytokines
T6194 3807-3842 Protein denotes Tumor necrosis factor alpha (TNF-α)
T6273 3836-3841 Protein denotes TNF-α
T6323 3847-3883 Protein denotes IL-1, two major macrophage products,
T6293 3853-3882 Entity denotes two major macrophage products
T6288 3863-3873 Entity denotes macrophage
T6248 3980-3988 Entity denotes effector
T6269 4011-4039 Protein denotes other inflammatory cytokines
T6165 4041-4051 Protein denotes chemokines
T6238 4069-4085 Protein denotes matrix proteases
T6174 4087-4099 Entity denotes nitric oxide
T6222 4135-4139 Protein denotes IL-6
T6196 4143-4213 Protein denotes a pleiotropic cytokine produced substantially by activated fibroblasts
T6264 4192-4213 Entity denotes activated fibroblasts
T6197 4315-4346 Entity denotes plasma cells, T-cell functions,
T6177 4329-4335 Entity denotes T-cell
T6220 4351-4379 Entity denotes hematopoietic precursor cell
T6319 4411-4438 Entity denotes anti-inflammatory cytokines
T6302 4411-4438 Protein denotes anti-inflammatory cytokines
T6277 4443-4462 Protein denotes cytokine inhibitors
T6262 4443-4462 Entity denotes cytokine inhibitors
T6184 4503-4505 Protein denotes RA
T6217 4514-4544 Protein denotes IL-10, produced by macrophages
T6365 4514-4544 Gene_expression denotes IL-10, produced by macrophages
T6335 4533-4544 Entity denotes macrophages
T6271 4559-4595 Entity denotes T cells in the synovial tissue (ST),
T6163 4591-4593 Protein denotes ST
T6244 4638-4648 Entity denotes macrophage
T6312 4653-4662 Entity denotes Th1 cells
T6204 4780-4817 Entity denotes the anti-inflammatory action of IL-10
T6195 4809-4817 Protein denotes of IL-10
T6265 4907-4912 Protein denotes IL-10
T6342 4907-4922 Positive_regulation denotes IL-10 signaling
T6368 4907-5023 Negative_regulation denotes IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1
T6276 4938-4949 Entity denotes macrophages
T6242 4975-5008 Protein denotes proinflammatory cytokines such as
T6332 4975-5014 Protein denotes proinflammatory cytokines such as TNF-α
T6303 5019-5023 Protein denotes IL-1
T6257 5028-5052 Entity denotes immune complexes [13,14]
T6209 5054-5066 Entity denotes Cell surface
T6351 5054-5088 Gene_expression denotes Cell surface expression of IL-10R1
T6189 5078-5088 Protein denotes of IL-10R1
T6308 5120-5229 Entity denotes dendritic cells due to the presence of TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15]
T6337 5159-5164 Protein denotes TNF-α
T6290 5166-5170 Protein denotes IL-1
T6281 5176-5198 Entity denotes granulocyte–macrophage
T6260 5176-5198 Entity denotes granulocyte–macrophage
T6179 5176-5229 Protein denotes granulocyte–macrophage colony-stimulating factor [15]
T6373 5176-5229 Localization denotes granulocyte–macrophage colony-stimulating factor [15]
T6192 5188-5198 Entity denotes macrophage
T6268 5231-5243 Entity denotes CD4+ T cells
T6210 5261-5287 Entity denotes by arthritogenic antigens,
T6229 5308-5321 Protein denotes CD28-mediated
T6350 5308-5352 Regulation denotes CD28-mediated costimulatory signaling, in RA
T6166 5350-5352 Protein denotes RA
T6187 5435-5474 Protein denotes the MHC class II antigens HLA-DRB1*0404
T6251 5435-5474 Protein denotes the MHC class II antigens HLA-DRB1*0404
T6205 5452-5460 Entity denotes antigens
T6301 5479-5505 Protein denotes HLA-DRB1*0401 with disease
T6320 5579-5591 Protein denotes MHC class II
T6236 5579-5601 Entity denotes MHC class II molecules
T6214 5606-5623 Entity denotes both CD28 ligands
T6170 5611-5615 Protein denotes CD28
T6314 5625-5629 Protein denotes CD80
T6254 5634-5638 Protein denotes CD86
T6245 5643-5666 Protein denotes the inflamed ST [18-20]
T6300 5696-5718 Entity denotes activated CD4+ T cells
T6278 5794-5805 Entity denotes macrophages
T6206 5810-5830 Entity denotes synovial fibroblasts
T6185 5839-5851 Entity denotes cell surface
T6338 5874-5886 Entity denotes cell surface
T6180 5874-5891 Protein denotes cell surface CD69
T6371 5874-5892 Localization denotes cell surface CD69
T6218 5896-5900 Protein denotes CD11
T6247 5944-5965 Protein denotes Th1 cytokines such as
T6243 5944-5976 Protein denotes Th1 cytokines such as interferon
T6325 5984-5987 Protein denotes IFN
T6291 5995-6000 Protein denotes IL-17
T6340 6010-6113 Positive_regulation denotes In addition, CD4+ T cells could stimulate B-cell production of autoantibodies such as rheumatoid factor true
T6173 6023-6035 Entity denotes CD4+ T cells
T6252 6052-6058 Entity denotes B-cell
T6360 6052-6095 Gene_expression denotes B-cell production of autoantibodies such as
T6233 6052-6113 Protein denotes B-cell production of autoantibodies such as rheumatoid factor
T6200 6070-6087 Protein denotes of autoantibodies
T6285 6118-6137 Entity denotes osteoclast-mediated
T6370 6118-6154 Regulation denotes osteoclast-mediated bone destruction
T6339 6181-6183 Protein denotes RA
T6343 6259-6300 Negative_regulation denotes selective inhibition of T-cell activation
T6172 6283-6289 Entity denotes T-cell
T6193 6313-6374 Protein denotes protein of cytotoxic T-cell-associated antigen 4 (CD152)-IgG,
T6239 6324-6374 Protein denotes cytotoxic T-cell-associated antigen 4 (CD152)-IgG,
T6333 6409-6413 Protein denotes CD28
T6318 6417-6424 Entity denotes T cells
T6352 6428-6475 Binding denotes binding to CD80 and CD86 with high avidity [23]
T6292 6439-6443 Protein denotes CD80
T6183 6448-6452 Protein denotes CD86
T6258 6477-6482 Protein denotes IL-10
T6334 6502-6547 Protein denotes the antigen-specific T-cell cytokine response
T6255 6506-6522 Entity denotes antigen-specific
T6329 6523-6529 Entity denotes T-cell
T6203 6566-6570 Protein denotes CD28
T6207 6648-6658 Entity denotes of antigen
T6201 6670-6675 Entity denotes cells
T6240 6705-6720 Entity denotes of CD4+ T cells
T6305 6750-6752 Protein denotes RA
T6357 6757-6793 Gene_expression denotes investigated the production of IFN-γ
T6226 6785-6793 Protein denotes of IFN-γ
T6270 6800-6803 Protein denotes CD3
T6299 6808-6812 Protein denotes CD28
T6348 6808-6826 Positive_regulation denotes CD28 costimulation
T6253 6846-6851 Protein denotes IL-10
T6364 6853-6885 Gene_expression denotes the induction of STAT1 and STAT3
T6363 6853-6885 Positive_regulation denotes the induction of STAT1 and STAT3
T6362 6853-6885 Positive_regulation denotes the induction of STAT1 and STAT3
T6361 6853-6885 Gene_expression denotes the induction of STAT1 and STAT3
T6309 6870-6875 Protein denotes STAT1
T6284 6880-6885 Protein denotes STAT3
T6280 6902-6910 Protein denotes by IL-10
T6367 6916-6949 Gene_expression denotes the expression of SOCS1 and SOCS3
T6366 6916-6949 Gene_expression denotes the expression of SOCS1 and SOCS3
T6261 6934-6939 Protein denotes SOCS1
T6223 6944-6949 Protein denotes SOCS3
T6324 6976-6978 Protein denotes PB
T6328 6980-6983 Protein denotes CD4
T6266 6985-6992 Entity denotes T cells
T6181 6993-7000 Protein denotes from RA
T7309 7115-7117 Protein denotes RA
T7307 7364-7391 Entity denotes prednisolone (≤ 7.5 mg/day)
T7310 7396-7433 Entity denotes disease-modifying antirheumatic drugs
T7304 7522-7533 Entity denotes erythrocyte
T7305 7581-7605 Protein denotes C-reactive protein (CRP)
T7308 7601-7604 Protein denotes CRP
T7306 7645-7662 Protein denotes rheumatoid factor
T7303 7670-7681 Entity denotes 142 ± 158 U
T7311 7823-7826 Protein denotes CRP
T7302 8084-8086 Protein denotes ST
T7301 8120-8122 Protein denotes RA
T7942 8214-8229 Entity denotes of CD4+ T cells
T7947 8230-8271 Entity denotes Peripheral blood mononuclear cells (PBMC)
T7933 8266-8270 Entity denotes PBMC
T7934 8403-8415 Entity denotes CD4+ T cells
T7929 8435-8461 Entity denotes PBMC by positive selection
T7941 8504-8519 Protein denotes Miltenyi Biotec
T7944 8587-8599 Entity denotes CD4+ T cells
T7932 8619-8621 Protein denotes ST
T7940 8676-8678 Protein denotes ST
T7939 8721-8732 Protein denotes collagenase
T7931 8737-8742 Protein denotes DNase
T7936 8793-8812 Entity denotes ST cell suspensions
T7943 8910-8940 Entity denotes 25 mM HEPES (2 mM L-glutamine,
T7938 8923-8939 Entity denotes 2 mM L-glutamine
T7946 8957-8969 Entity denotes amino acids,
T7935 8980-8991 Entity denotes penicillin,
T7930 9000-9018 Entity denotes mg/ml streptomycin
T7945 9172-9190 Entity denotes Non-adherent cells
T7948 9172-9205 Binding denotes Non-adherent cells were harvested
T7937 9210-9222 Entity denotes CD4+ T cells
T8565 9290-9305 Entity denotes of CD4+ T cells
T8563 9306-9337 Protein denotes PB CD4+ T-cell populations were
T8569 9314-9320 Entity denotes T-cell
T8566 9419-9442 Entity denotes 0.5 ml cell suspensions
T8560 9419-9442 Entity denotes 0.5 ml cell suspensions
T8555 9518-9539 Protein denotes with 1 μg/ml anti-CD3
T8564 9577-9586 Entity denotes The cells
T8557 9701-9709 Protein denotes of IL-10
T8571 9807-9827 Entity denotes Culture supernatants
T8568 9862-9871 Entity denotes cell-free
T8561 9907-9921 Protein denotes cytokine assay
T8567 9945-9952 Protein denotes of IL-6
T8574 9956-9962 Entity denotes T-cell
T8572 9978-9986 Protein denotes to IL-10
T8556 9988-10022 Entity denotes CD4+ T cells from healthy controls
T8573 10088-10112 Protein denotes absence of 10 ng/ml IL-6
T8562 10146-10151 Entity denotes Cells
T8558 10208-10217 Protein denotes anti-CD28
T8570 10249-10265 Protein denotes of 1 ng/ml IL-10
T8559 10306-10326 Protein denotes IFN-γ concentrations
T8969 10358-10365 Protein denotes IL-10R1
T8978 10358-10376 Gene_expression denotes IL-10R1 expression
T8976 10386-10410 Entity denotes of 5 × 105 cells of PBMC
T8966 10406-10410 Entity denotes PBMC
T8973 10447-10451 Entity denotes PBMC
T8967 10519-10523 Protein denotes IgG1
T8974 10670-10694 Protein denotes IgG1 polyclonal antibody
T8970 10670-10694 Protein denotes IgG1 polyclonal antibody
T8975 10696-10735 Protein denotes Santa Cruz Biotechnologies, Santa Cruz,
T8977 10746-10751 Entity denotes Cells
T8968 10757-10810 Protein denotes then incubated with phycoerythrin-conjugated anti-CD4
T8971 10835-10840 Entity denotes Cells
T8972 10863-10893 Entity denotes 1% FCS/PBS between incubations
T9275 10983-10988 Protein denotes IFN-γ
T9279 10993-10997 Protein denotes IL-2
T9274 11016-11021 Protein denotes IFN-γ
T9270 11026-11030 Protein denotes IL-2
T9280 11034-11070 Entity denotes culture supernatants of CD4+ T cells
T9273 11058-11070 Entity denotes CD4+ T cells
T9276 11139-11156 Protein denotes cytokine-specific
T9278 11201-11230 Protein denotes recombinant cytokine proteins
T9272 11201-11230 Protein denotes recombinant cytokine proteins
T9271 11327-11332 Protein denotes IFN-γ
T9277 11337-11341 Protein denotes IL-2
T10517 11371-11375 Protein denotes mRNA
T10523 11380-11393 Protein denotes real-time PCR
T10509 11432-11434 Protein denotes PB
T10514 11432-11474 Entity denotes PB CD4+ T cells using an RNA isolation kit
T10520 11457-11460 Protein denotes RNA
T10529 11593-11602 Protein denotes total RNA
T10510 11608-11658 Protein denotes Molony murine leukemia virus reverse transcriptase
T10533 11706-11712 Entity denotes (dT)15
T10519 11750-11763 Protein denotes Real-time PCR
T10531 11899-11902 Protein denotes Taq
T10530 11899-11917 Protein denotes Taq DNA polymerase
T10528 11922-11925 Entity denotes DNA
T10511 11922-11961 Entity denotes DNA double-strand-specific SYBR Green I
T10532 11979-11988 Entity denotes FastStart
T10527 11989-12012 Entity denotes DNA Master SYBR Green I
T10524 11989-12012 Entity denotes DNA Master SYBR Green I
T10515 12234-12258 Protein denotes β-actin; at 95° C (10 s)
T10534 12301-12306 Protein denotes SOCS1
T10526 12370-12375 Protein denotes SOCS3
T10516 12466-12473 Protein denotes melting
T10518 12523-12528 Protein denotes SOCS1
T10525 12533-12538 Protein denotes SOCS3
T10522 12593-12600 Protein denotes β-actin
T10535 12593-12611 Gene_expression denotes β-actin expression
T10521 12666-12674 Protein denotes β-actin,
T10513 12743-12749 Protein denotes SOCS1,
T10512 12818-12824 Protein denotes SOCS3,
T11878 12903-12915 Entity denotes CD4+ T cells
T11855 12978-12983 Protein denotes IL-10
T11875 12988-12992 Protein denotes IL-6
T11836 13006-13022 Entity denotes of 5 × 105 cells
T11888 13062-13122 Regulation denotes To examine the effect of serum IL-6 on STAT phosphorylation,
T11866 13084-13097 Protein denotes of serum IL-6
T11889 13098-13121 Phosphorylation denotes on STAT phosphorylation
T11838 13101-13105 Protein denotes STAT
T11870 13123-13142 Entity denotes normal CD4+ T cells
T11834 13186-13188 Protein denotes RA
T11837 13255-13274 Protein denotes polyclonal antibody
T11827 13383-13388 Entity denotes cells
T11853 13392-13402 Protein denotes 100 μl SDS
T11883 13403-13409 Protein denotes lysing
T11844 13426-13434 Entity denotes Tris–HCl
T11880 13426-13434 Entity denotes Tris–HCl
T11832 13431-13434 Entity denotes HCl
T11879 13436-13440 Entity denotes pH 6
T11839 13445-13510 Entity denotes 2% SDS, 10% glycerol, 50 mM dithiothreitol, 0.1% bromphenol blue)
T11847 13448-13466 Protein denotes SDS, 10% glycerol,
T11830 13453-13465 Entity denotes 10% glycerol
T11869 13523-13538 Protein denotes protein samples
T11846 13560-13587 Entity denotes 10% SDS-polyacrylamide gels
T11848 13564-13567 Protein denotes SDS
T11841 13568-13582 Entity denotes polyacrylamide
T11876 13612-13626 Entity denotes nitrocellulose
T11862 13612-13668 Entity denotes nitrocellulose membranes (Amersham, Buckinghamshire, UK)
T11833 13638-13667 Protein denotes Amersham, Buckinghamshire, UK
T11877 13674-13686 Entity denotes the membrane
T11873 13720-13733 Entity denotes Tris-buffered
T11843 13720-13740 Entity denotes Tris-buffered saline
T11887 13761-13769 Entity denotes Tyrosine
T11891 13761-13877 Phosphorylation denotes Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,
T11890 13761-13877 Phosphorylation denotes Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,
T11874 13789-13794 Protein denotes STAT1
T11831 13799-13804 Protein denotes STAT3
T11885 13851-13855 Entity denotes Cell
T11881 13951-13963 Entity denotes the membrane
T11852 13983-14010 Entity denotes the antibodies (rabbit IgG)
T11849 14011-14031 Entity denotes anti-STAT1 antibody,
T11886 14011-14031 Protein denotes anti-STAT1 antibody,
T11856 14032-14160 Entity denotes anti-phosphorylated tyrosine 701 of STAT1 antibody, anti-STAT3 antibody, and anti-phosphorylated tyrosine 705 of STAT3 antibody,
T11884 14068-14073 Protein denotes STAT1
T11865 14068-14082 Entity denotes STAT1 antibody
T11857 14084-14103 Protein denotes anti-STAT3 antibody
T11829 14084-14103 Entity denotes anti-STAT3 antibody
T11858 14109-14160 Entity denotes anti-phosphorylated tyrosine 705 of STAT3 antibody,
T11867 14145-14150 Protein denotes STAT3
T11850 14145-14160 Protein denotes STAT3 antibody,
T11854 14199-14212 Entity denotes Tris-buffered
T11860 14199-14250 Entity denotes Tris-buffered saline with 0.1% Tween 20 with 5% BSA
T11851 14225-14250 Entity denotes 0.1% Tween 20 with 5% BSA
T11861 14244-14250 Protein denotes 5% BSA
T11828 14252-14260 Protein denotes Antibody
T11868 14285-14307 Protein denotes horseradish peroxidase
T11872 14367-14380 Entity denotes Tris-buffered
T11835 14367-14397 Entity denotes Tris-buffered saline with 0.1%
T11842 14412-14419 Protein denotes 5% BSA,
T11882 14473-14518 Entity denotes Protein bands were quantified by densitometry
T11845 14549-14553 Protein denotes STAT
T11892 14549-14620 Phosphorylation denotes STAT phosphorylation was compared with the total amount of STAT protein
T11864 14605-14620 Protein denotes of STAT protein
T11863 14608-14612 Protein denotes STAT
T11859 14622-14627 Protein denotes IFN-γ
T11840 14628-14649 Entity denotes stimulated Hela cells
T11871 14686-14691 Protein denotes STAT1
T12071 14801-14810 Entity denotes box plots
T14335 15012-15017 Protein denotes IL-10
T14340 15012-15067 Negative_regulation denotes IL-10 inhibition of IFN-γ production in RA CD4+ T cells
T14336 15029-15048 Gene_expression denotes of IFN-γ production
T14326 15032-15037 Protein denotes IFN-γ
T14321 15052-15054 Protein denotes RA
T14327 15052-15067 Entity denotes RA CD4+ T cells
T14315 15068-15098 Protein denotes The CD28 costimulatory pathway
T14271 15114-15140 Entity denotes effective antigen-specific
T14318 15173-15178 Protein denotes IL-10
T14270 15229-15233 Protein denotes CD28
T14295 15229-15258 Entity denotes CD28 tyrosine phosphorylation
T14319 15274-15303 Protein denotes phosphatidylinositol 3-kinase
T14279 15341-15359 Entity denotes of RA CD4+ T cells
T14301 15344-15346 Protein denotes RA
T14290 15363-15369 Protein denotes IL-10,
T14274 15379-15381 Protein denotes PB
T14294 15379-15394 Entity denotes PB CD4+ T cells
T14313 15420-15429 Protein denotes active RA
T14277 15498-15501 Protein denotes CD3
T14291 15498-15510 Protein denotes CD3 antibody
T14302 15515-15524 Protein denotes anti-CD28
T14322 15525-15533 Protein denotes antibody
T14316 15573-15595 Protein denotes of IL-10 for 36 hours,
T14304 15600-15605 Protein denotes IFN-γ
T14350 15600-15616 Gene_expression denotes IFN-γ production
T14276 15652-15655 Protein denotes Fig
T14324 15660-15665 Protein denotes IFN-γ
T14348 15660-15709 Gene_expression denotes IFN-γ production by activated normal CD4+ T cells
T14314 15677-15709 Entity denotes by activated normal CD4+ T cells
T14312 15714-15772 Protein denotes mostly inhibited at concentrations as low as 1 ng/ml IL-10
T14334 15783-15785 Protein denotes RA
T14333 15783-15798 Entity denotes RA CD4+ T cells
T14305 15840-15848 Protein denotes of IFN-γ
T14298 15868-15881 Protein denotes 1 ng/ml IL-10
T14342 15887-15948 Binding denotes the maximal but not complete inhibition by IL-10 was obtained
T14306 15927-15935 Protein denotes by IL-10
T14286 15997-16002 Protein denotes IFN-γ
T14341 15997-16029 Gene_expression denotes IFN-γ production by CD4+ T cells
T14285 16014-16029 Entity denotes by CD4+ T cells
T14283 16036-16039 Protein denotes CD3
T14297 16044-16048 Protein denotes CD28
T14339 16044-16062 Positive_regulation denotes CD28 costimulation
T14329 16082-16110 Protein denotes 1 ng/ml IL-10 in RA patients
T14309 16099-16101 Protein denotes RA
T14299 16162-16165 Protein denotes CRP
T14323 16219-16222 Protein denotes CRP
T14320 16325-16330 Protein denotes IFN-γ
T14346 16325-16380 Gene_expression denotes IFN-γ production without IL-10 among these three groups
T14325 16350-16355 Protein denotes IL-10
T14293 16382-16385 Protein denotes Fig
T14349 16411-16446 Regulation denotes effect of IL-10 on IFN-γ production
T14337 16411-16495 Negative_regulation denotes effect of IL-10 on IFN-γ production was significantly limited in the active RA group
T14296 16418-16426 Protein denotes of IL-10
T14338 16427-16446 Gene_expression denotes on IFN-γ production
T14269 16430-16435 Protein denotes IFN-γ
T14328 16487-16489 Protein denotes RA
T14288 16526-16528 Protein denotes RA
T14272 16578-16587 Protein denotes active RA
T14273 16602-16613 Protein denotes inactive RA
T14278 16653-16656 Protein denotes Fig
T14287 16681-16717 Entity denotes CD4+ T cells from active RA patients
T14332 16706-16708 Protein denotes RA
T14281 16744-16749 Protein denotes IFN-γ
T14308 16769-16782 Protein denotes 1 ng/ml IL-10
T14330 16792-16811 Entity denotes normal CD4+ T cells
T14344 16823-16912 Gene_expression denotes In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation
T14303 16848-16852 Protein denotes IL-2
T14310 16864-16912 Entity denotes by CD4+ T cells after CD3 and CD28 costimulation
T14275 16886-16889 Protein denotes CD3
T14280 16894-16898 Protein denotes CD28
T14343 16894-16912 Positive_regulation denotes CD28 costimulation
T14300 16932-16983 Protein denotes IL-10 in active RA patients and in healthy controls
T14289 16948-16950 Protein denotes RA
T14307 16996-17000 Protein denotes IL-2
T14345 16996-17011 Gene_expression denotes IL-2 production
T14347 16996-17082 Regulation denotes IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease, true
T14331 17029-17045 Protein denotes by 1 ng/ml IL-10
T14317 17049-17051 Protein denotes RA
T14311 17154-17171 Entity denotes 61.1 ± 13.7%; P <
T14282 17223-17225 Protein denotes RA
T14284 17223-17238 Entity denotes RA CD4+ T cells
T14292 17294-17302 Protein denotes of IL-10
T15283 17350-17392 Localization denotes of cell surface IL-10R1 on RA CD4+ T cells
T15257 17350-17392 Protein denotes of cell surface IL-10R1 on RA CD4+ T cells
T15256 17350-17392 Entity denotes of cell surface IL-10R1 on RA CD4+ T cells
T15259 17353-17365 Entity denotes cell surface
T15263 17377-17379 Protein denotes RA
T15278 17393-17433 Entity denotes The functional receptor complex of IL-10
T15262 17393-17433 Protein denotes The functional receptor complex of IL-10
T15264 17425-17433 Protein denotes of IL-10
T15277 17460-17502 Protein denotes the primary ligand-binding component IL-10
T15273 17460-17502 Entity denotes the primary ligand-binding component IL-10
T15269 17502-17504 Protein denotes R1
T15275 17538-17550 Protein denotes 2 IL-10R [1]
T15276 17552-17559 Protein denotes IL-10R1
T15286 17552-17570 Gene_expression denotes IL-10R1 expression
T15271 17618-17628 Protein denotes IL-10 [29]
T15272 17667-17672 Protein denotes IL-10
T15285 17667-17683 Negative_regulation denotes IL-10 inhibition
T15279 17687-17689 Protein denotes RA
T15261 17687-17702 Entity denotes RA CD4+ T cells
T15288 17714-17742 Negative_regulation denotes limited receptor expression,
T15287 17714-17742 Gene_expression denotes limited receptor expression,
T15274 17722-17730 Protein denotes receptor
T15266 17743-17759 Entity denotes the cell surface
T15282 17774-17781 Protein denotes IL-10R1
T15255 17774-17800 Entity denotes IL-10R1 on PB CD4+ T cells
T15265 17785-17787 Protein denotes PB
T15267 17813-17815 Protein denotes RA
T15270 17907-17910 Protein denotes Fig
T15284 17933-17954 Gene_expression denotes of IL-10R1 expression
T15268 17936-17943 Protein denotes IL-10R1
T15281 17958-17970 Entity denotes CD4+ T cells
T15258 18002-18004 Protein denotes RA
T15280 18125-18130 Protein denotes IL-10
T15260 18150-18175 Entity denotes CD4+ T cells of active RA
T15254 18166-18175 Protein denotes active RA
T16949 18178-18193 Protein denotes Defective IL-10
T17010 18178-18243 Regulation denotes Defective IL-10-mediated STAT3 phosphorylation in RA CD4+ T cells
T16968 18203-18208 Protein denotes STAT3
T17007 18203-18243 Phosphorylation denotes STAT3 phosphorylation in RA CD4+ T cells
T16969 18228-18230 Protein denotes RA
T16976 18228-18243 Entity denotes RA CD4+ T cells
T17006 18244-18280 Binding denotes The interaction of IL-10R with IL-10
T16960 18260-18269 Protein denotes of IL-10R
T16981 18270-18280 Protein denotes with IL-10
T16999 18289-18297 Entity denotes tyrosine
T17018 18318-18370 Positive_regulation denotes activation of the latent transcription factors STAT1
T16948 18329-18370 Protein denotes of the latent transcription factors STAT1
T16983 18329-18370 Protein denotes of the latent transcription factors STAT1
T16950 18375-18384 Protein denotes STAT3 [3]
T16984 18386-18405 Entity denotes Macrophage-specific
T16986 18386-18426 Protein denotes Macrophage-specific STAT3-deficient mice
T16959 18445-18450 Protein denotes STAT3
T16997 18476-18490 Protein denotes IL-10-mediated
T16951 18561-18578 Entity denotes human macrophages
T17017 18590-18636 Positive_regulation denotes of dominant-negative STAT3 overexpression [30]
T17016 18590-18636 Gene_expression denotes of dominant-negative STAT3 overexpression [30]
T16980 18590-18636 Protein denotes of dominant-negative STAT3 overexpression [30]
T16963 18602-18616 Protein denotes negative STAT3
T16977 18655-18660 Protein denotes STAT1
T16982 18665-18670 Protein denotes STAT3
T17005 18665-18686 Phosphorylation denotes STAT3 phosphorylation
T16952 18687-18705 Protein denotes by IL-10 in PB CD4
T16993 18699-18701 Protein denotes PB
T16970 18699-18705 Protein denotes PB CD4
T16994 18707-18738 Entity denotes T cells from active RA patients
T16973 18727-18729 Protein denotes RA
T16985 18802-18807 Protein denotes STAT3
T17002 18802-18823 Phosphorylation denotes STAT3 phosphorylation
T16987 18859-18864 Protein denotes IL-10
T17013 18859-18882 Positive_regulation denotes IL-10 activation for 20
T16967 18890-18909 Entity denotes normal CD4+ T cells
T17001 18911-18914 Protein denotes Fig
T17008 18924-18995 Phosphorylation denotes In contrast, STAT3 was phosphorylated in freshly isolated PB CD4+ cells
T16971 18937-18942 Protein denotes STAT3
T16998 18965-18995 Entity denotes freshly isolated PB CD4+ cells
T17000 18982-18984 Protein denotes PB
T16964 19001-19003 Protein denotes RA
T17014 19017-19043 Phosphorylation denotes this STAT3 phosphorylation
T16957 19022-19027 Protein denotes STAT3
T16991 19078-19083 Protein denotes STAT3
T17004 19078-19099 Phosphorylation denotes STAT3 phosphorylation
T16955 19104-19162 Protein denotes augmented only when activated by as much as 10 ng/ml IL-10
T16990 19179-19184 Protein denotes STAT3
T17020 19179-19200 Phosphorylation denotes STAT3 phosphorylation
T16995 19205-19228 Protein denotes defective IL-10-induced
T17003 19205-19250 Phosphorylation denotes defective IL-10-induced STAT3 phosphorylation
T16965 19229-19234 Protein denotes STAT3
T16975 19265-19267 Protein denotes RA
T16954 19265-19283 Entity denotes RA ST CD4+ T cells
T16953 19265-19283 Protein denotes RA ST CD4+ T cells
T16962 19285-19288 Protein denotes Fig
T17009 19295-19415 Phosphorylation denotes On the other hand, IL-10-induced STAT1 phosphorylation was not detected in either RA CD4+ T cells or normal CD4+ T cells
T16972 19314-19327 Protein denotes IL-10-induced
T16996 19328-19333 Protein denotes STAT1
T16946 19377-19379 Protein denotes RA
T16974 19377-19392 Entity denotes RA CD4+ T cells
T16961 19396-19415 Entity denotes normal CD4+ T cells
T16979 19417-19420 Protein denotes Fig
T16992 19455-19460 Protein denotes STAT3
T17012 19464-19510 Positive_regulation denotes the major IL-10-activated STAT in CD4+ T cells
T16947 19464-19510 Protein denotes the major IL-10-activated STAT in CD4+ T cells
T17019 19464-19510 Localization denotes the major IL-10-activated STAT in CD4+ T cells
T16978 19468-19489 Protein denotes major IL-10-activated
T16958 19498-19510 Entity denotes CD4+ T cells
T16966 19516-19529 Protein denotes IL-10-induced
T17015 19516-19546 Positive_regulation denotes IL-10-induced STAT3 activation
T16989 19530-19535 Protein denotes STAT3
T16956 19568-19578 Protein denotes active RA,
T17011 19594-19630 Phosphorylation denotes with sustained STAT3 phosphorylation
T16988 19609-19614 Protein denotes STAT3
T19733 19633-19637 Protein denotes IL-6
T19727 19647-19652 Protein denotes STAT3
T19800 19647-19668 Phosphorylation denotes STAT3 phosphorylation
T19788 19673-19713 Negative_regulation denotes inhibition of IL-10 effect in normal CD4
T19718 19687-19692 Protein denotes IL-10
T19743 19703-19713 Protein denotes normal CD4
T19736 19715-19722 Entity denotes T cells
T19706 19723-19728 Protein denotes STAT3
T19794 19723-19741 Positive_regulation denotes STAT3 is activated
T19755 19791-19795 Protein denotes IL-6
T19776 19806-19875 Protein denotes cytokines (IL-6, IL-11, leukemia inhibitory factor, and oncostatin M)
T19716 19817-19821 Protein denotes IL-6
T19760 19823-19828 Protein denotes IL-11
T19768 19830-19856 Protein denotes leukemia inhibitory factor
T19707 19862-19874 Protein denotes oncostatin M
T19762 19877-19907 Protein denotes platelet-derived growth factor
T19721 19913-19936 Protein denotes epidermal growth factor
T19780 19953-19963 Protein denotes IL-10 [4],
T19779 20008-20012 Protein denotes IL-6
T19710 20036-20038 Protein denotes RA
T19796 20067-20125 Positive_regulation denotes constitutive activation of STAT3 in mononuclear cells [31]
T19764 20091-20099 Protein denotes of STAT3
T19744 20103-20125 Entity denotes mononuclear cells [31]
T19709 20133-20137 Protein denotes IL-6
T19703 20158-20185 Protein denotes sera of active RA patients,
T19731 20173-20175 Protein denotes RA
T19766 20265-20280 Entity denotes of CD4+ T cells
T19726 20304-20311 Protein denotes of IL-6
T19741 20373-20378 Protein denotes STAT3
T19717 20408-20413 Protein denotes IL-10
T19801 20408-20437 Negative_regulation denotes IL-10 inhibition in active RA
T19752 20428-20437 Protein denotes active RA
T19750 20444-20449 Protein denotes STAT1
T19730 20454-20459 Protein denotes STAT3
T19705 20490-20497 Protein denotes by IL-6
T19711 20501-20537 Entity denotes normal CD4+ T cells (data not shown)
T19778 20584-20594 Protein denotes Normal CD4
T19745 20596-20603 Entity denotes T cells
T19758 20688-20690 Protein denotes RA
T19729 20717-20755 Entity denotes anti-IL-6 antibody or control antibody
T19777 20727-20735 Entity denotes antibody
T19771 20761-20765 Protein denotes STAT
T19797 20761-20819 Phosphorylation denotes STAT phosphorylation was examined by western blot analysis
T19747 20821-20823 Protein denotes RA
T19754 20849-20857 Entity denotes tyrosine
T19795 20849-20896 Phosphorylation denotes tyrosine phosphorylation of STAT3 but not STAT1
T19712 20874-20882 Protein denotes of STAT3
T19742 20891-20896 Protein denotes STAT1
T19789 20902-20923 Positive_regulation denotes this STAT3 activation
T19756 20907-20912 Protein denotes STAT3
T19738 20966-20970 Protein denotes IL-6
T19732 20981-20984 Protein denotes Fig
T19763 21019-21023 Protein denotes IL-6
T19781 21077-21103 Protein denotes sera of active RA patients
T19751 21092-21094 Protein denotes RA
T19787 21114-21133 Positive_regulation denotes of STAT1 activation
T19737 21117-21122 Protein denotes STAT1
T19753 21134-21139 Protein denotes by RA
T19769 21187-21194 Protein denotes of IL-6
T19715 21215-21220 Protein denotes STAT1
T19783 21215-21231 Positive_regulation denotes STAT1 activation
T19798 21244-21265 Positive_regulation denotes with STAT3 activation
T19740 21249-21254 Protein denotes STAT3
T19713 21270-21304 Entity denotes that inhibitors of STAT1 signaling
T19720 21289-21294 Protein denotes STAT1
T19793 21289-21304 Positive_regulation denotes STAT1 signaling
T19761 21323-21325 Entity denotes RA
T19773 21358-21362 Protein denotes IL-6
T19791 21358-21432 Negative_regulation denotes IL-6 could suppress the effect of IL-10 to inhibit IFN-γ production by CD4 true
T19767 21389-21397 Protein denotes of IL-10
T19799 21401-21432 Negative_regulation denotes inhibit IFN-γ production by CD4
T19746 21409-21414 Protein denotes IFN-γ
T19786 21409-21432 Gene_expression denotes IFN-γ production by CD4
T19704 21426-21432 Protein denotes by CD4
T19757 21434-21441 Entity denotes T cells
T19722 21479-21506 Protein denotes 10 ng/ml IL-6 for 36 hours,
T19708 21507-21526 Entity denotes normal CD4+ T cells
T19714 21546-21549 Protein denotes CD3
T19765 21554-21558 Protein denotes CD28
T19785 21554-21572 Positive_regulation denotes CD28 costimulation
T19772 21600-21630 Protein denotes of 1 ng/ml IL-10 for 36 hours,
T19784 21635-21655 Gene_expression denotes the IFN-γ production
T19724 21639-21644 Protein denotes IFN-γ
T19735 21679-21683 Protein denotes IL-6
T19734 21700-21712 Entity denotes normal cells
T19725 21721-21735 Protein denotes IL-10-mediated
T19782 21721-21746 Regulation denotes IL-10-mediated inhibition
T19728 21750-21755 Protein denotes IFN-γ
T19790 21750-21766 Gene_expression denotes IFN-γ production
T19739 21768-21771 Protein denotes Fig
T19774 21814-21821 Protein denotes of IL-6
T19748 21837-21843 Entity denotes T-cell
T19775 21859-21867 Protein denotes to IL-10
T19770 21942-21946 Protein denotes IL-6
T19792 21985-22004 Positive_regulation denotes of STAT3 activation
T19723 21988-21993 Protein denotes STAT3
T19719 22049-22057 Protein denotes of IL-10
T19749 22061-22063 Protein denotes RA
T19759 22061-22076 Entity denotes RA CD4+ T cells
T21417 22079-22127 Gene_expression denotes High expression of SOCS1 mRNA in RA CD4+ T cells
T21362 22095-22108 Protein denotes of SOCS1 mRNA
T21398 22098-22103 Protein denotes SOCS1
T21410 22112-22114 Protein denotes RA
T21385 22112-22127 Entity denotes RA CD4+ T cells
T21376 22128-22132 Protein denotes IL-6
T21388 22141-22197 Entity denotes two potent inhibitors of JAKs (SOCS1 and SOCS3 proteins)
T21379 22166-22197 Protein denotes JAKs (SOCS1 and SOCS3 proteins)
T21382 22172-22177 Protein denotes SOCS1
T21364 22182-22187 Protein denotes SOCS3
T21407 22182-22196 Protein denotes SOCS3 proteins
T21396 22325-22362 Protein denotes other cytokine-signaling pathways [7]
T21375 22364-22369 Protein denotes SOCS3
T21401 22418-22423 Protein denotes STAT3
T21419 22418-22467 Positive_regulation denotes STAT3 activation induced by IL-6 but not by IL-10
T21405 22443-22450 Protein denotes by IL-6
T21380 22462-22467 Protein denotes IL-10
T21391 22512-22516 Protein denotes IL-6
T21361 22521-22526 Protein denotes IL-10
T21366 22551-22556 Protein denotes SOCS1
T21404 22586-22600 Protein denotes IL-10-mediated
T21424 22586-22617 Regulation denotes IL-10-mediated STAT3 activation
T21423 22586-22617 Positive_regulation denotes IL-10-mediated STAT3 activation
T21400 22601-22606 Protein denotes STAT3
T21386 22653-22667 Protein denotes IFN-γ-mediated
T21416 22653-22689 Positive_regulation denotes IFN-γ-mediated STAT1 activation [32]
T21415 22653-22689 Regulation denotes IFN-γ-mediated STAT1 activation [32]
T21365 22668-22673 Protein denotes STAT1
T21422 22732-22789 Positive_regulation denotes in the defective IL-10-induced STAT3 activation of RA CD4
T21411 22739-22762 Protein denotes defective IL-10-induced
T21395 22763-22768 Protein denotes STAT3
T21392 22780-22789 Protein denotes of RA CD4
T21409 22783-22785 Protein denotes RA
T21394 22791-22798 Entity denotes T cells
T21412 22814-22819 Protein denotes SOCS1
T21378 22814-22834 Protein denotes SOCS1 and SOCS3 mRNA
T21421 22814-22914 Gene_expression denotes SOCS1 and SOCS3 mRNA expression in PB CD4+ T cells from active RA patients and from healthy controls
T21420 22814-22914 Transcription denotes SOCS1 and SOCS3 mRNA expression in PB CD4+ T cells from active RA patients and from healthy controls
T21370 22824-22829 Protein denotes SOCS3
T21390 22849-22851 Protein denotes PB
T21372 22849-22864 Entity denotes PB CD4+ T cells
T21368 22877-22879 Protein denotes RA
T21374 22929-22962 Protein denotes by semiquantitative real-time PCR
T21377 22964-22983 Entity denotes The RA CD4+ T cells
T21367 22968-22970 Protein denotes RA
T21363 23011-23016 Protein denotes SOCS1
T21383 23037-23042 Protein denotes SOCS3
T21387 23037-23054 Protein denotes SOCS3 transcripts
T21369 23072-23094 Entity denotes CD4+ T cells (Fig. 6a)
T21414 23109-23152 Gene_expression denotes expression of SOCS1 mRNA in RA CD4+ T cells
T21399 23120-23133 Protein denotes of SOCS1 mRNA
T21384 23123-23128 Protein denotes SOCS1
T21371 23137-23139 Protein denotes RA
T21397 23137-23152 Entity denotes RA CD4+ T cells
T21406 23191-23238 Protein denotes normal CD4+ T cells stimulated by 10 ng/ml IL-6
T21418 23191-23239 Localization denotes normal CD4+ T cells stimulated by 10 ng/ml IL-6
T21393 23203-23210 Entity denotes T cells
T21408 23240-23243 Protein denotes Fig
T21403 23290-23305 Protein denotes Defective IL-10
T21402 23314-23319 Protein denotes STAT3
T21413 23314-23330 Positive_regulation denotes STAT3 activation
T21373 23392-23400 Protein denotes of SOCS1
T21381 23404-23406 Protein denotes RA
T21389 23404-23419 Entity denotes RA CD4+ T cells
T29887 23433-23445 Entity denotes CD4+ T cells
T29982 23504-23511 Protein denotes RA [22]
T29825 23513-23535 Entity denotes Activated CD4+ T cells
T29785 23546-23557 Entity denotes macrophages
T29780 23559-23579 Entity denotes synovial fibroblasts
T29883 23581-23588 Entity denotes B cells
T29964 23594-23605 Entity denotes osteoclasts
T29749 23629-23644 Entity denotes of cell surface
T29711 23645-23654 Entity denotes molecules
T29756 23659-23673 Protein denotes Th1 cytokines,
T29987 23755-23767 Entity denotes CD4+ T cells
T29854 23805-23812 Entity denotes antigen
T29787 23805-23821 Protein denotes antigen receptor
T29860 23836-23849 Protein denotes CD28-mediated
T30041 23836-23863 Regulation denotes CD28-mediated costimulation
T29783 23868-23900 Protein denotes the ST lesion, the CD28 ligands,
T29808 23883-23899 Entity denotes the CD28 ligands
T29870 23887-23891 Protein denotes CD28
T29980 23906-23910 Protein denotes CD80
T29706 23915-23919 Protein denotes CD86
T29939 23935-23947 Protein denotes MHC class II
T29923 23935-23956 Entity denotes MHC class II antigens
T29905 23989-23996 Entity denotes antigen
T29966 23997-24033 Entity denotes presenting cells such as macrophages
T29823 24008-24021 Entity denotes cells such as
T29683 24038-24061 Entity denotes dendritic cells [18-20]
T29739 24080-24087 Protein denotes of CD28
T29713 24106-24121 Entity denotes T-cell-mediated
T30017 24191-24272 Protein denotes its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23]
T30001 24191-24272 Entity denotes its blocker cytotoxic T-cell-associated antigen 4 (CD152)-IgG in RA patients [23]
T29850 24256-24258 Protein denotes RA
T29704 24274-24279 Protein denotes IL-10
T29682 24386-24397 Entity denotes macrophages
T29744 24402-24411 Entity denotes Th1 cells
T29875 24417-24422 Protein denotes IL-10
T30099 24432-24481 Phosphorylation denotes the tyrosine phosphorylation of the CD28 molecule
T29903 24436-24444 Entity denotes tyrosine
T29979 24461-24481 Protein denotes of the CD28 molecule
T29972 24542-24549 Entity denotes T cells
T29769 24580-24592 Entity denotes T cells [24]
T29994 24630-24632 Protein denotes PB
T29800 24630-24675 Entity denotes PB CD4+ T cells from patients with active RA,
T29853 24665-24674 Protein denotes active RA
T29716 24695-24701 Protein denotes IL-10,
T29732 24739-24744 Protein denotes IFN-γ
T29695 24751-24754 Protein denotes CD3
T29985 24759-24763 Protein denotes CD28
T30037 24759-24777 Positive_regulation denotes CD28 costimulation
T29986 24778-24802 Entity denotes than normal CD4+ T cells
T29685 24823-24830 Protein denotes IL-10R1
T30050 24846-24876 Positive_regulation denotes constitutive STAT3 activation,
T29691 24859-24864 Protein denotes STAT3
T29984 24877-24890 Protein denotes IL-10-induced
T30040 24877-24924 Phosphorylation denotes IL-10-induced tyrosine phosphorylation of STAT3
T29760 24891-24899 Entity denotes tyrosine
T29873 24916-24924 Protein denotes of STAT3
T30002 24942-24944 Protein denotes RA
T29936 24942-24957 Entity denotes RA CD4+ T cells
T29858 24974-24984 Protein denotes normal CD4
T29726 24986-24993 Entity denotes T cells
T29705 25001-25006 Protein denotes STAT3
T30105 25001-25022 Phosphorylation denotes STAT3 phosphorylation
T30003 25056-25061 Protein denotes IL-10
T29672 25063-25073 Protein denotes Serum IL-6
T30112 25063-25157 Gene_expression denotes Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
T30111 25063-25157 Positive_regulation denotes Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
T29742 25079-25081 Protein denotes RA
T29965 25099-25134 Protein denotes STAT3 but not STAT1 phosphorylation
T29896 25113-25118 Protein denotes STAT1
T30029 25113-25134 Phosphorylation denotes STAT1 phosphorylation
T29919 25138-25157 Entity denotes normal CD4+ T cells
T29945 25163-25177 Protein denotes exogenous IL-6
T29851 25204-25209 Protein denotes IL-10
T30026 25204-25240 Negative_regulation denotes IL-10 inhibition of IFN-γ production
T30066 25221-25240 Gene_expression denotes of IFN-γ production
T30007 25224-25229 Protein denotes IFN-γ
T30005 25242-25244 Protein denotes RA
T29673 25242-25257 Entity denotes RA CD4+ T cells
T29799 25283-25288 Protein denotes SOCS1
T29734 25317-25322 Protein denotes SOCS3
T29819 25317-25334 Protein denotes SOCS3 transcripts
T29871 25354-25373 Entity denotes normal CD4+ T cells
T29772 25404-25416 Entity denotes CD4+ T cells
T29988 25459-25467 Protein denotes of IL-10
T29688 25490-25506 Protein denotes the inflamed ST,
T30061 25563-25587 Negative_regulation denotes impaired IL-10-dependent
T29956 25563-25587 Protein denotes impaired IL-10-dependent
T30067 25563-25667 Positive_regulation denotes impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1
T30035 25563-25667 Regulation denotes impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1
T29999 25588-25593 Protein denotes STAT3
T30045 25626-25657 Phosphorylation denotes sustained STAT3 phosphorylation
T29872 25636-25641 Protein denotes STAT3
T29699 25662-25667 Protein denotes SOCS1
T29709 25679-25693 Protein denotes IL-10-mediated
T30108 25679-25739 Regulation denotes IL-10-mediated inhibition of CD4+ T-cell cytokine production
T30025 25679-25815 Regulation denotes IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting
T29741 25705-25739 Entity denotes of CD4+ T-cell cytokine production
T29948 25783-25815 Entity denotes of macrophage antigen-presenting
T30014 25786-25796 Entity denotes macrophage
T29943 25816-25820 Entity denotes cell
T29963 25919-25925 Entity denotes T-cell
T29997 25940-25942 Protein denotes RA
T29813 25952-25973 Entity denotes macrophages in the ST
T29932 25967-25973 Protein denotes the ST
T29747 25997-26006 Protein denotes cytokines
T29842 25997-26032 Entity denotes cytokines, CD80 and CD86 molecules,
T29941 26008-26012 Protein denotes CD80
T29798 26017-26021 Protein denotes CD86
T29927 26037-26049 Protein denotes MHC class II
T30006 26037-26058 Entity denotes MHC class II antigens
T29668 26086-26091 Protein denotes IL-10
T29852 26121-26137 Entity denotes antigen-specific
T29778 26138-26144 Entity denotes T-cell
T30059 26165-26210 Negative_regulation denotes inhibiting CD28 tyrosine phosphorylation [33]
T29786 26176-26180 Protein denotes CD28
T29720 26176-26210 Entity denotes CD28 tyrosine phosphorylation [33]
T30082 26212-26273 Negative_regulation denotes This direct effect also may be limited in active RA patients, true
T29755 26261-26263 Protein denotes RA
T29954 26288-26290 Protein denotes PB
T29840 26288-26294 Protein denotes PB CD4
T29951 26296-26303 Entity denotes T cells
T30022 26296-26394 Negative_regulation denotes T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
T30021 26296-26394 Negative_regulation denotes T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
T29992 26323-26328 Protein denotes IL-10
T30086 26340-26394 Positive_regulation denotes of CD28-costimulated production of both IFN-γ and IL-2
T30085 26340-26394 Positive_regulation denotes of CD28-costimulated production of both IFN-γ and IL-2
T30028 26340-26394 Gene_expression denotes of CD28-costimulated production of both IFN-γ and IL-2
T30027 26340-26394 Gene_expression denotes of CD28-costimulated production of both IFN-γ and IL-2
T29947 26343-26360 Protein denotes CD28-costimulated
T29915 26380-26385 Protein denotes IFN-γ
T29920 26390-26394 Protein denotes IL-2
T30010 26396-26495 Protein denotes Numerous cytokines, both proinflammatory and anti-inflammatory, have been detected in the ST of RA,
T29848 26482-26494 Protein denotes the ST of RA
T29729 26492-26494 Protein denotes RA
T30090 26588-26614 Gene_expression denotes Endogenous IL-10, produced
T29834 26588-26614 Protein denotes Endogenous IL-10, produced
T29977 26625-26636 Entity denotes macrophages
T29892 26641-26648 Entity denotes T cells
T29697 26698-26700 Protein denotes ST
T29836 26698-26711 Entity denotes ST cells [12]
T29890 26822-26916 Entity denotes the extracellular stimulus-regulated kinase and p38 kinase pathways, induced by TNF-α and IL-1
T29995 26840-26865 Protein denotes stimulus-regulated kinase
T29718 26870-26873 Protein denotes p38
T29930 26870-26890 Protein denotes p38 kinase pathways,
T29674 26902-26907 Protein denotes TNF-α
T29754 26912-26916 Protein denotes IL-1
T29867 26927-26984 Protein denotes the Jak1–STAT3 signaling pathway shared by IL-10 and IL-6
T29894 26936-26941 Protein denotes STAT3
T29746 26970-26975 Protein denotes IL-10
T29686 26980-26984 Protein denotes IL-6
T29885 26996-27012 Entity denotes macrophages [13]
T29667 27032-27046 Protein denotes IL-10-mediated
T30068 27032-27063 Positive_regulation denotes IL-10-mediated STAT3 activation
T30054 27032-27063 Regulation denotes IL-10-mediated STAT3 activation
T29809 27047-27052 Protein denotes STAT3
T29924 27090-27092 Protein denotes RA
T29893 27090-27113 Entity denotes RA synovial macrophages
T30106 27115-27144 Positive_regulation denotes This impaired IL-10 signaling
T30098 27115-27144 Negative_regulation denotes This impaired IL-10 signaling
T29679 27129-27134 Protein denotes IL-10
T29770 27188-27213 Entity denotes immune complexes in vivo,
T29703 27227-27258 Entity denotes cell surface IL-10R1 expression
T29931 27240-27247 Protein denotes IL-10R1
T29829 27263-27276 Protein denotes IL-10-induced
T30024 27263-27292 Positive_regulation denotes IL-10-induced Jak1 activation
T29751 27277-27281 Protein denotes Jak1
T29675 27311-27375 Entity denotes IFN-γ-primed macrophages by a protein kinase C-dependent pathway
T29849 27341-27367 Protein denotes protein kinase C-dependent
T29795 27398-27404 Protein denotes the Ig
T29888 27415-27428 Protein denotes receptor [14]
T29816 27443-27458 Entity denotes dendritic cells
T29759 27464-27466 Protein denotes RA
T29991 27528-27536 Protein denotes of IL-10
T29961 27564-27588 Protein denotes of intracellular IL-10R1
T30062 27564-27589 Localization denotes of intracellular IL-10R1
T29864 27567-27580 Entity denotes intracellular
T29913 27624-27632 Protein denotes cytokine
T29899 27633-27719 Protein denotes stimuli such as TNF-α, IL-1, and granulocyte–macrophage colony-stimulating factor [15]
T29882 27656-27661 Protein denotes IL-1,
T29929 27666-27719 Protein denotes granulocyte–macrophage colony-stimulating factor [15]
T29946 27762-27771 Protein denotes of RA CD4
T29696 27765-27767 Protein denotes RA
T29731 27773-27780 Entity denotes T cells
T30042 27773-27888 Positive_regulation denotes T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression
T29681 27784-27789 Protein denotes IL-10
T30023 27808-27888 Regulation denotes with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression
T29815 27813-27838 Protein denotes defective IL-10-dependent
T29721 27839-27844 Protein denotes STAT3
T29839 27870-27877 Protein denotes IL-10R1
T30096 27870-27888 Gene_expression denotes IL-10R1 expression
T30016 27912-27917 Protein denotes IL-10
T29752 27927-27944 Entity denotes inflammatory cell
T29880 28061-28063 Protein denotes RA
T30076 28080-28125 Regulation denotes with impaired IL-10-mediated STAT3 activation
T30030 28080-28125 Positive_regulation denotes with impaired IL-10-mediated STAT3 activation
T30063 28085-28108 Negative_regulation denotes impaired IL-10-mediated
T29960 28085-28108 Protein denotes impaired IL-10-mediated
T30004 28109-28114 Protein denotes STAT3
T29730 28127-28132 Protein denotes STAT3
T29766 28149-28157 Entity denotes tyrosine
T29764 28222-28224 Protein denotes PB
T29768 28222-28244 Entity denotes PB and ST CD4+ T cells
T29820 28229-28236 Protein denotes ST CD4+
T29938 28250-28252 Protein denotes RA
T29806 28263-28268 Protein denotes STAT3
T30113 28263-28281 Positive_regulation denotes STAT3 is activated
T29811 28295-28308 Protein denotes of cytokines,
T30018 28321-28325 Protein denotes IL-6
T29690 28336-28410 Protein denotes cytokines (e.g. IL-6, IL-11, leukemia inhibitory factor, and oncostatin M)
T29916 28352-28356 Protein denotes IL-6
T29684 28358-28363 Protein denotes IL-11
T29918 28365-28391 Protein denotes leukemia inhibitory factor
T29865 28397-28409 Protein denotes oncostatin M
T29790 28446-28455 Protein denotes IL-10 [4]
T29832 28460-28476 Protein denotes these cytokines,
T29810 28477-28481 Protein denotes IL-6
T29758 28576-28586 Protein denotes active RA,
T29967 28675-28679 Protein denotes IL-6
T29750 28751-28753 Protein denotes RA
T29998 28787-28795 Protein denotes to IL-10
T29847 28814-28833 Entity denotes normal CD4+ T cells
T29670 28868-28872 Protein denotes IL-6
T29959 28920-28925 Protein denotes STAT3
T30114 28920-28936 Positive_regulation denotes STAT3 activation
T29877 28959-28964 Protein denotes IL-10
T30103 28959-28975 Negative_regulation denotes IL-10 inhibition
T29822 28985-28987 Protein denotes RA
T29827 28985-29000 Entity denotes RA CD4+ T cells
T29957 29079-29083 Protein denotes IL-6
T29866 29114-29124 Protein denotes that STAT3
T29928 29169-29181 Entity denotes CD4+ T cells
T29774 29195-29200 Protein denotes IL-10
T29793 29250-29265 Protein denotes exogenous IL-10
T29773 29275-29277 Protein denotes RA
T29971 29275-29300 Entity denotes RA CD4+ T cells in the ST
T29969 29294-29300 Protein denotes the ST
T29974 29348-29358 Protein denotes IL-10 [34]
T29970 29360-29399 Entity denotes CD4+ T cells isolated from the ST of RA
T29990 29382-29399 Protein denotes from the ST of RA
T29855 29397-29399 Protein denotes RA
T29803 29428-29441 Protein denotes IL-10-induced
T29910 29442-29447 Protein denotes STAT3
T30008 29507-29522 Entity denotes of CD4+ T cells
T29745 29526-29531 Protein denotes IL-10
T29983 29575-29591 Protein denotes the inflamed ST,
T29814 29600-29604 Protein denotes IL-6
T29942 29728-29737 Protein denotes cytokines
T29775 29818-29832 Protein denotes IL-10-mediated
T30094 29818-29865 Regulation denotes IL-10-mediated IFN-γ inhibition in CD4+ T cells
T30038 29818-29865 Negative_regulation denotes IL-10-mediated IFN-γ inhibition in CD4+ T cells
T29728 29833-29838 Protein denotes IFN-γ
T29968 29853-29865 Entity denotes CD4+ T cells
T29879 29899-29904 Protein denotes IL-1β
T29762 29909-29914 Protein denotes TNF-α
T29781 29950-29971 Protein denotes IL-6 (data not shown)
T29693 29986-29991 Protein denotes IFN-γ
T30084 29996-30026 Gene_expression denotes IL-10 produced by CD4+ T cells
T29784 29996-30026 Protein denotes IL-10 produced by CD4+ T cells
T29868 30011-30026 Entity denotes by CD4+ T cells
T30097 30059-30098 Positive_regulation denotes for impaired IL-10 signaling in the ST,
T30047 30059-30098 Negative_regulation denotes for impaired IL-10 signaling in the ST,
T30015 30072-30077 Protein denotes IL-10
T29937 30091-30097 Protein denotes the ST
T29861 30107-30113 Entity denotes T-cell
T29789 30134-30156 Protein denotes both cytokines [34,35]
T29689 30183-30188 Protein denotes IL-10
T30049 30183-30232 Positive_regulation denotes IL-10 may persistently stimulate STAT3 activation true
T29792 30216-30221 Protein denotes STAT3
T30093 30216-30232 Positive_regulation denotes STAT3 activation
T29733 30237-30242 Protein denotes IFN-γ
T30075 30237-30267 Gene_expression denotes IFN-γ can induce SOCS1 protein true
T30074 30237-30267 Positive_regulation denotes IFN-γ can induce SOCS1 protein true
T29895 30254-30259 Protein denotes SOCS1
T29909 30254-30267 Protein denotes SOCS1 protein
T29856 30283-30316 Entity denotes inhibitor of IL-10 signaling [32]
T30019 30296-30301 Protein denotes IL-10
T30095 30296-30316 Positive_regulation denotes IL-10 signaling [32]
T30083 30318-30455 Regulation denotes The T-cell-inhibitory effect of IL-10 may therefore be modulated complicatedly upon exposure to an inflammatory environment in RA joints, true
T29949 30347-30355 Protein denotes of IL-10
T29700 30445-30447 Protein denotes RA
T29978 30462-30476 Protein denotes many cytokines
T29940 30509-30514 Protein denotes STAT3
T30101 30509-30525 Positive_regulation denotes STAT3 activation
T29862 30569-30571 Protein denotes RA
T29801 30573-30585 Protein denotes Active STAT3
T30053 30573-30671 Gene_expression denotes Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36]
T29723 30617-30649 Entity denotes synovial fluid mononuclear cells
T29859 30655-30657 Protein denotes RA
T29891 30673-30677 Protein denotes IL-6
T29835 30681-30740 Protein denotes the major STAT3-activating factor present in synovial fluid
T30056 30785-30875 Gene_expression denotes of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
T30055 30785-30875 Gene_expression denotes of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
T29735 30788-30796 Entity denotes monocyte
T29771 30834-30862 Protein denotes the Fc gamma receptor type I
T29837 30867-30875 Protein denotes type III
T29694 30936-30941 Protein denotes STAT3
T29692 30975-30980 Protein denotes IL-6,
T29917 31003-31009 Protein denotes the ST
T29976 31015-31020 Protein denotes STAT3
T30104 31015-31123 Positive_regulation denotes STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37]
T29944 31103-31107 Protein denotes IL-6
T30036 31103-31123 Gene_expression denotes IL-6 production [37]
T29796 31141-31146 Protein denotes STAT3
T30011 31189-31241 Entity denotes of growth factor-dependent synovial fibroblasts [38]
T29846 31192-31215 Protein denotes growth factor-dependent
T29680 31287-31292 Protein denotes STAT3
T30087 31287-31324 Positive_regulation denotes STAT3 signaling in Th1-cell-dominated
T29911 31376-31403 Protein denotes of the gp130F759/F759 mice,
T29935 31417-31420 Protein denotes Src
T29710 31430-31441 Protein denotes phosphatase
T29874 31457-31545 Protein denotes of gp130 (the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor)
T29743 31467-31544 Protein denotes the transmembrane glycoprotein β subunit of the IL-6 family cytokine receptor
T29950 31547-31559 Entity denotes tyrosine 759
T30012 31576-31594 Entity denotes phenylalanine [39]
T29724 31618-31632 Protein denotes mice, T cells,
T29838 31624-31631 Entity denotes T cells
T29902 31655-31661 Entity denotes T-cell
T29881 31751-31765 Protein denotes gp130-mediated
T30107 31751-31782 Positive_regulation denotes gp130-mediated STAT3 activation
T30100 31751-31782 Regulation denotes gp130-mediated STAT3 activation
T29765 31766-31771 Protein denotes STAT3
T30013 31801-31809 Protein denotes cytokine
T29958 31829-31852 Protein denotes by the JAK–STAT pathway
T29776 31840-31844 Protein denotes STAT
T29826 31866-31897 Protein denotes by the SOCS family proteins [7]
T29676 31873-31877 Protein denotes SOCS
T29748 31913-31954 Entity denotes CD4+ T cells from patients with active RA
T29933 31945-31954 Protein denotes active RA
T29828 31982-31987 Protein denotes SOCS1
T29981 32009-32015 Protein denotes SOCS3,
T29926 32025-32049 Entity denotes with normal CD4+ T cells
T29912 32051-32056 Protein denotes SOCS1
T30072 32051-32110 Negative_regulation denotes SOCS1 prevents activation of JAK by directly binding to JAK
T30051 32051-32110 Binding denotes SOCS1 prevents activation of JAK by directly binding to JAK
T30058 32066-32083 Positive_regulation denotes activation of JAK
T29884 32077-32083 Protein denotes of JAK
T29671 32104-32110 Protein denotes to JAK
T29794 32116-32121 Protein denotes SOCS3
T30057 32116-32240 Binding denotes SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
T29975 32142-32148 Protein denotes of JAK
T29805 32160-32240 Entity denotes to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
T29908 32167-32170 Protein denotes Src
T29897 32212-32229 Protein denotes receptors such as
T29876 32212-32240 Protein denotes receptors such as gp130 [40]
T29952 32242-32247 Protein denotes SOCS1
T30034 32242-32380 Positive_regulation denotes SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30033 32242-32380 Gene_expression denotes SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30032 32242-32380 Positive_regulation denotes SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T30031 32242-32380 Gene_expression denotes SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]
T29701 32252-32257 Protein denotes SOCS3
T29886 32270-32317 Protein denotes by various cytokines, including IL-6 and IL-10,
T29818 32302-32306 Protein denotes IL-6
T29725 32311-32316 Protein denotes IL-10
T29708 32402-32429 Protein denotes mice lacking SOCS3 or SOCS1
T29779 32415-32420 Protein denotes SOCS3
T29669 32424-32429 Protein denotes SOCS1
T29906 32444-32449 Protein denotes SOCS3
T29833 32477-32481 Protein denotes IL-6
T30060 32477-32491 Positive_regulation denotes IL-6 signaling
T29698 32503-32508 Protein denotes IL-10
T30052 32503-32518 Positive_regulation denotes IL-10 signaling
T29804 32528-32548 Protein denotes of conditional SOCS3
T29687 32549-32563 Protein denotes deficient mice
T29767 32580-32623 Protein denotes SOCS3 deficiency, but not SOCS1 deficiency,
T29831 32606-32623 Protein denotes SOCS1 deficiency,
T29996 32659-32664 Protein denotes STAT3
T29817 32680-32684 Protein denotes IL-6
T29921 32709-32714 Protein denotes SOCS3
T29962 32715-32736 Entity denotes deficient macrophages
T29737 32751-32761 Protein denotes that SOCS3
T29791 32765-32834 Entity denotes a crucial inhibitor of the IL-6-induced transcriptional response [42]
T29841 32845-32850 Protein denotes SOCS3
T29973 32940-32948 Protein denotes of IL-10
T29922 32952-32968 Entity denotes macrophages [41]
T30020 32970-33052 Negative_regulation denotes On the contrary, SOCS1 was found to directly inhibit IL-10-mediated signaling [43]
T29934 32987-32992 Protein denotes SOCS1
T29807 33023-33037 Protein denotes IL-10-mediated
T30102 33023-33052 Regulation denotes IL-10-mediated signaling [43]
T29797 33064-33069 Protein denotes SOCS1
T30089 33064-33099 Gene_expression denotes SOCS1 expression in RA CD4+ T cells
T30064 33064-33137 Binding denotes SOCS1 expression in RA CD4+ T cells may therefore be associated with both
T29722 33084-33086 Protein denotes RA
T29993 33084-33099 Entity denotes RA CD4+ T cells
T29844 33169-33174 Protein denotes IL-10
T29845 33182-33196 Protein denotes IL-10-mediated
T30077 33182-33214 Positive_regulation denotes IL-10-mediated STAT3 activation,
T30048 33182-33214 Regulation denotes IL-10-mediated STAT3 activation,
T29777 33197-33202 Protein denotes STAT3
T30039 33219-33245 Gene_expression denotes defective SOCS3 expression
T29914 33229-33234 Protein denotes SOCS3
T30065 33265-33296 Positive_regulation denotes for persistent STAT3 activation
T29869 33280-33285 Protein denotes STAT3
T29989 33318-33322 Protein denotes IL-6
T29857 33352-33357 Protein denotes SOCS1
T30110 33352-33367 Gene_expression denotes SOCS1 induction
T30109 33352-33367 Positive_regulation denotes SOCS1 induction
T29678 33403-33418 Entity denotes of CD4+ T cells
T30080 33419-33435 Gene_expression denotes to produce IFN-γ
T30000 33430-33435 Protein denotes IFN-γ
T29900 33445-33472 Entity denotes CD4+ T cells from active RA
T30009 33463-33472 Protein denotes active RA
T29863 33502-33507 Protein denotes IFN-γ
T29714 33527-33533 Protein denotes IL-10,
T29821 33546-33551 Protein denotes IFN-γ
T29707 33587-33595 Protein denotes of SOCS1
T29727 33670-33679 Entity denotes Th2 cells
T29738 33703-33708 Protein denotes SOCS1
T29717 33713-33718 Protein denotes SOCS3
T29702 33713-33723 Protein denotes SOCS3 mRNA
T29782 33744-33757 Protein denotes IL-12-induced
T30081 33744-33774 Positive_regulation denotes IL-12-induced STAT4 activation
T30070 33744-33820 Negative_regulation denotes IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,
T30069 33744-33820 Negative_regulation denotes IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,
T29889 33758-33763 Protein denotes STAT4
T30044 33788-33820 Gene_expression denotes by SOCS3 induction in Th2 cells,
T30043 33788-33820 Positive_regulation denotes by SOCS3 induction in Th2 cells,
T29740 33791-33796 Protein denotes SOCS3
T29753 33810-33819 Entity denotes Th2 cells
T29843 33829-33841 Protein denotes IL-4-induced
T30073 33829-33857 Positive_regulation denotes IL-4-induced STAT6 signaling
T30092 33829-33903 Negative_regulation denotes IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
T30091 33829-33903 Negative_regulation denotes IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
T29898 33842-33847 Protein denotes STAT6
T30079 33872-33903 Positive_regulation denotes by SOCS1 induction in Th1 cells
T30078 33872-33903 Gene_expression denotes by SOCS1 induction in Th1 cells
T29736 33875-33880 Protein denotes SOCS1
T29824 33894-33903 Entity denotes Th1 cells
T29878 33905-33910 Protein denotes SOCS1
T29761 33915-33920 Protein denotes SOCS3
T29955 34034-34044 Protein denotes IL-4–STAT6
T29953 34034-34044 Protein denotes IL-4–STAT6
T29925 34039-34044 Protein denotes STAT6
T29712 34053-34064 Protein denotes IL-12–STAT4
T29757 34053-34064 Protein denotes IL-12–STAT4
T29901 34059-34064 Protein denotes STAT4
T29719 34128-34130 Protein denotes PB
T29907 34128-34175 Entity denotes PB T cells from patients with allergic diseases
T29802 34213-34218 Protein denotes SOCS3
T29812 34213-34231 Protein denotes SOCS3 transcripts,
T30071 34236-34256 Gene_expression denotes the SOCS3 expression
T29830 34240-34245 Protein denotes SOCS3
T30046 34323-34346 Gene_expression denotes Higher SOCS1 expression
T29715 34330-34335 Protein denotes SOCS1
T30088 34352-34374 Gene_expression denotes lower SOCS3 expression
T29904 34358-34363 Protein denotes SOCS3
T29788 34378-34385 Protein denotes PB CD4+
T29677 34386-34393 Entity denotes T cells
T29763 34399-34401 Protein denotes RA
T31533 34584-34596 Entity denotes CD4+ T cells
T31520 34609-34611 Protein denotes RA
T31530 34662-34667 Protein denotes IL-10
T31548 34662-34741 Negative_regulation denotes IL-10 inhibition of IFN-γ production, due to constitutive STAT3 phosphorylation
T31551 34679-34699 Gene_expression denotes of IFN-γ production,
T31518 34682-34687 Protein denotes IFN-γ
T31547 34707-34741 Phosphorylation denotes constitutive STAT3 phosphorylation
T31531 34720-34725 Protein denotes STAT3
T31535 34755-34769 Protein denotes IL-10-mediated
T31549 34755-34786 Regulation denotes IL-10-mediated STAT3 activation
T31544 34755-34786 Positive_regulation denotes IL-10-mediated STAT3 activation
T31525 34770-34775 Protein denotes STAT3
T31550 34788-34817 Positive_regulation denotes The defective STAT3 signaling
T31536 34802-34807 Protein denotes STAT3
T31519 34846-34851 Protein denotes SOCS1
T31534 34870-34875 Protein denotes SOCS3
T31539 34900-34909 Protein denotes active RA
T31522 34989-34996 Protein denotes of IL-6
T31521 35019-35027 Protein denotes of IL-10
T31526 35041-35043 Protein denotes RA
T31537 35110-35138 Protein denotes IL-10 of inflammatory cells,
T31538 35119-35138 Entity denotes inflammatory cells,
T31532 35149-35156 Entity denotes T cells
T31516 35252-35254 Protein denotes RA
T31529 35329-35336 Entity denotes T cells
T31542 35345-35394 Negative_regulation denotes the inhibition of IL-6-dependent STAT3 activation
T31543 35360-35394 Regulation denotes of IL-6-dependent STAT3 activation
T31541 35360-35394 Positive_regulation denotes of IL-6-dependent STAT3 activation
T31527 35363-35377 Protein denotes IL-6-dependent
T31517 35378-35383 Protein denotes STAT3
T31528 35428-35433 Protein denotes STAT3
T31540 35428-35444 Positive_regulation denotes STAT3 activation
T31546 35475-35507 Positive_regulation denotes the induction of the SOCS3 gene,
T31545 35475-35507 Gene_expression denotes the induction of the SOCS3 gene,
T31524 35489-35506 Protein denotes of the SOCS3 gene
T31523 35496-35501 Protein denotes SOCS3
R10018 T19706 T19794 themeOf STAT3,STAT3 is activated
R10019 T19712 T19795 themeOf of STAT3,tyrosine phosphorylation of STAT3 but not STAT1
R10020 T19715 T19783 themeOf STAT1,STAT1 activation
R10021 T19717 T19801 themeOf IL-10,IL-10 inhibition in active RA
R10022 T19720 T19793 causeOf STAT1,STAT1 signaling
R10023 T19723 T19792 themeOf STAT3,of STAT3 activation
R10024 T19724 T19784 themeOf IFN-γ,the IFN-γ production
R10025 T19725 T19782 causeOf IL-10-mediated,IL-10-mediated inhibition
R10026 T19727 T19800 themeOf STAT3,STAT3 phosphorylation
R10027 T19728 T19790 themeOf IFN-γ,IFN-γ production
R10028 T19737 T19787 themeOf STAT1,of STAT1 activation
R10029 T19740 T19798 themeOf STAT3,with STAT3 activation
R10030 T19746 T19786 themeOf IFN-γ,IFN-γ production by CD4
R10031 T19754 T19712 partOf tyrosine,of STAT3
R10032 T19754 T19795 siteOf tyrosine,tyrosine phosphorylation of STAT3 but not STAT1
R10033 T19756 T19789 themeOf STAT3,this STAT3 activation
R10034 T19764 T19796 themeOf of STAT3,constitutive activation of STAT3 in mononuclear cells [31]
R10035 T19765 T19785 themeOf CD28,CD28 costimulation
R10036 T19771 T19797 themeOf STAT,STAT phosphorylation was examined by western blot analysis
R10037 T19773 T19791 causeOf IL-6,IL-6 could suppress the effect of IL-10 to inhibit IFN-γ production by CD4
R10038 T19786 T19799 themeOf IFN-γ production by CD4,inhibit IFN-γ production by CD4
R10803 T21362 T21417 themeOf of SOCS1 mRNA,High expression of SOCS1 mRNA in RA CD4+ T cells
R10804 T21365 T21416 themeOf STAT1,IFN-γ-mediated STAT1 activation [32]
R10805 T21378 T21420 themeOf SOCS1 and SOCS3 mRNA,SOCS1 and SOCS3 mRNA expression in PB CD4+ T cells from active RA patients and from healthy controls
R10806 T21378 T21421 themeOf SOCS1 and SOCS3 mRNA,SOCS1 and SOCS3 mRNA expression in PB CD4+ T cells from active RA patients and from healthy controls
R10807 T21386 T21415 causeOf IFN-γ-mediated,IFN-γ-mediated STAT1 activation [32]
R10808 T21392 T21422 themeOf of RA CD4,in the defective IL-10-induced STAT3 activation of RA CD4
R10809 T21393 T21418 locationOf T cells,normal CD4+ T cells stimulated by 10 ng/ml IL-6
R10810 T21395 T21422 causeOf STAT3,in the defective IL-10-induced STAT3 activation of RA CD4
R10811 T21399 T21414 themeOf of SOCS1 mRNA,expression of SOCS1 mRNA in RA CD4+ T cells
R10812 T21400 T21423 themeOf STAT3,IL-10-mediated STAT3 activation
R10813 T21401 T21419 themeOf STAT3,STAT3 activation induced by IL-6 but not by IL-10
R10814 T21402 T21413 themeOf STAT3,STAT3 activation
R10815 T21404 T21424 causeOf IL-10-mediated,IL-10-mediated STAT3 activation
R10816 T21406 T21418 themeOf normal CD4+ T cells stimulated by 10 ng/ml IL-6,normal CD4+ T cells stimulated by 10 ng/ml IL-6
R10817 T21416 T21415 themeOf IFN-γ-mediated STAT1 activation [32],IFN-γ-mediated STAT1 activation [32]
R10818 T21423 T21424 themeOf IL-10-mediated STAT3 activation,IL-10-mediated STAT3 activation
R15936 T29667 T30054 causeOf IL-10-mediated,IL-10-mediated STAT3 activation
R15940 T29671 T30051 themeOf to JAK,SOCS1 prevents activation of JAK by directly binding to JAK
R15942 T29672 T30111 causeOf Serum IL-6,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R15945 T29679 T30106 causeOf IL-10,This impaired IL-10 signaling
R15946 T29680 T30087 causeOf STAT3,STAT3 signaling in Th1-cell-dominated
R15949 T29689 T30049 causeOf IL-10,IL-10 may persistently stimulate STAT3 activation
R15950 T29691 T30050 themeOf STAT3,"constitutive STAT3 activation,"
R15952 T29698 T30052 causeOf IL-10,IL-10 signaling
R15955 T29701 T30031 themeOf SOCS3,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R15956 T29701 T30034 themeOf SOCS3,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R15959 T29705 T30105 themeOf STAT3,STAT3 phosphorylation
R15961 T29709 T30108 causeOf IL-10-mediated,IL-10-mediated inhibition of CD4+ T-cell cytokine production
R15964 T29715 T30046 themeOf SOCS1,Higher SOCS1 expression
R15965 T29721 T30042 themeOf STAT3,"T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R15967 T29751 T30024 themeOf Jak1,IL-10-induced Jak1 activation
R15968 T29728 T30038 themeOf IFN-γ,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R15969 T29733 T30074 causeOf IFN-γ,IFN-γ can induce SOCS1 protein
R15970 T29760 T29873 partOf tyrosine,of STAT3
R15971 T29736 T30078 themeOf SOCS1,by SOCS1 induction in Th1 cells
R15972 T29736 T30079 themeOf SOCS1,by SOCS1 induction in Th1 cells
R15973 T29740 T30043 themeOf SOCS3,"by SOCS3 induction in Th2 cells,"
R15974 T29740 T30044 themeOf SOCS3,"by SOCS3 induction in Th2 cells,"
R15975 T29760 T30040 siteOf tyrosine,IL-10-induced tyrosine phosphorylation of STAT3
R15976 T29765 T30107 themeOf STAT3,gp130-mediated STAT3 activation
R15977 T29815 T30023 causeOf defective IL-10-dependent,"with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R15978 T29771 T30056 themeOf the Fc gamma receptor type I,of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
R15979 T29775 T30094 causeOf IL-10-mediated,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R15980 T29777 T30077 themeOf STAT3,"IL-10-mediated STAT3 activation,"
R15981 T29830 T30071 themeOf SOCS3,the SOCS3 expression
R15982 T29833 T30060 causeOf IL-6,IL-6 signaling
R15983 T29834 T30090 themeOf "Endogenous IL-10, produced","Endogenous IL-10, produced"
R15984 T29784 T30084 themeOf IL-10 produced by CD4+ T cells,IL-10 produced by CD4+ T cells
R15985 T29837 T30055 themeOf type III,of monocyte functions such as gene expression of the Fc gamma receptor type I and type III
R15986 T29839 T30096 themeOf IL-10R1,IL-10R1 expression
R15987 T29845 T30048 causeOf IL-10-mediated,"IL-10-mediated STAT3 activation,"
R15988 T29792 T30093 themeOf STAT3,STAT3 activation
R15989 T29851 T30026 causeOf IL-10,IL-10 inhibition of IFN-γ production
R15990 T29794 T30057 themeOf SOCS3,SOCS3 inhibits the action of JAK by binding to the Src homology phosphatase-2-binding domain of receptors such as gp130 [40]
R15991 T29797 T30089 themeOf SOCS1,SOCS1 expression in RA CD4+ T cells
R15992 T29857 T30109 themeOf SOCS1,SOCS1 induction
R15993 T29857 T30110 themeOf SOCS1,SOCS1 induction
R15994 T29860 T30041 causeOf CD28-mediated,CD28-mediated costimulation
R15995 T29801 T30053 themeOf Active STAT3,Active STAT3 is constitutively expressed in synovial fluid mononuclear cells from RA patients [36]
R15996 T29864 T30062 locationOf intracellular,of intracellular IL-10R1
R15997 T29806 T30113 themeOf STAT3,STAT3 is activated
R15998 T29869 T30065 themeOf STAT3,for persistent STAT3 activation
R15999 T29872 T30045 themeOf STAT3,sustained STAT3 phosphorylation
R16000 T29873 T30040 themeOf of STAT3,IL-10-induced tyrosine phosphorylation of STAT3
R16001 T29807 T30102 causeOf IL-10-mediated,IL-10-mediated signaling [43]
R16002 T29809 T30068 themeOf STAT3,IL-10-mediated STAT3 activation
R16003 T29877 T30103 themeOf IL-10,IL-10 inhibition
R16004 T29889 T30081 themeOf STAT4,IL-12-induced STAT4 activation
R16005 T29881 T30100 causeOf gp130-mediated,gp130-mediated STAT3 activation
R16006 T29884 T30058 themeOf of JAK,activation of JAK
R16007 T29886 T30032 causeOf "by various cytokines, including IL-6 and IL-10,","SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16008 T29886 T30034 causeOf "by various cytokines, including IL-6 and IL-10,","SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16009 T29896 T30029 themeOf STAT1,STAT1 phosphorylation
R16010 T29898 T30073 causeOf STAT6,IL-4-induced STAT6 signaling
R16011 T29992 T30021 causeOf IL-10,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16012 T29992 T30022 causeOf IL-10,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16013 T29903 T29979 partOf tyrosine,of the CD28 molecule
R16014 T29999 T30067 themeOf STAT3,"impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16015 T30000 T30080 themeOf IFN-γ,to produce IFN-γ
R16016 T29903 T30099 siteOf tyrosine,the tyrosine phosphorylation of the CD28 molecule
R16017 T30004 T30030 themeOf STAT3,with impaired IL-10-mediated STAT3 activation
R16018 T29904 T30088 themeOf SOCS3,lower SOCS3 expression
R16019 T30007 T30066 themeOf IFN-γ,of IFN-γ production
R16020 T29909 T30074 themeOf SOCS1 protein,IFN-γ can induce SOCS1 protein
R16021 T29909 T30075 themeOf SOCS1 protein,IFN-γ can induce SOCS1 protein
R16022 T30015 T30097 causeOf IL-10,"for impaired IL-10 signaling in the ST,"
R16023 T29912 T30051 themeOf SOCS1,SOCS1 prevents activation of JAK by directly binding to JAK
R16024 T30019 T30095 causeOf IL-10,IL-10 signaling [32]
R16025 T29914 T30039 themeOf SOCS3,defective SOCS3 expression
R16026 T29915 T30028 themeOf IFN-γ,of CD28-costimulated production of both IFN-γ and IL-2
R16027 T30027 T30021 themeOf of CD28-costimulated production of both IFN-γ and IL-2,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16028 T30027 T30086 themeOf of CD28-costimulated production of both IFN-γ and IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16029 T29920 T30027 themeOf IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16030 T30028 T30022 themeOf of CD28-costimulated production of both IFN-γ and IL-2,T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2
R16031 T30028 T30085 themeOf of CD28-costimulated production of both IFN-γ and IL-2,of CD28-costimulated production of both IFN-γ and IL-2
R16032 T30030 T30076 themeOf with impaired IL-10-mediated STAT3 activation,with impaired IL-10-mediated STAT3 activation
R16033 T29940 T30101 themeOf STAT3,STAT3 activation
R16034 T30038 T30094 themeOf IL-10-mediated IFN-γ inhibition in CD4+ T cells,IL-10-mediated IFN-γ inhibition in CD4+ T cells
R16035 T30042 T30023 themeOf "T cells to IL-10 may be associated with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression","with defective IL-10-dependent STAT3 activation, but not with IL-10R1 expression"
R16036 T30043 T30069 causeOf "by SOCS3 induction in Th2 cells,","IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16037 T30044 T30070 causeOf "by SOCS3 induction in Th2 cells,","IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16038 T30058 T30072 themeOf activation of JAK,SOCS1 prevents activation of JAK by directly binding to JAK
R16039 T29944 T30036 themeOf IL-6,IL-6 production [37]
R16040 T30066 T30026 themeOf of IFN-γ production,IL-10 inhibition of IFN-γ production
R16041 T30067 T30035 themeOf "impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1","impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16042 T29947 T30085 causeOf CD28-costimulated,of CD28-costimulated production of both IFN-γ and IL-2
R16043 T30068 T30054 themeOf IL-10-mediated STAT3 activation,IL-10-mediated STAT3 activation
R16044 T29947 T30086 causeOf CD28-costimulated,of CD28-costimulated production of both IFN-γ and IL-2
R16045 T30073 T30091 themeOf IL-4-induced STAT6 signaling,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16046 T30073 T30092 themeOf IL-4-induced STAT6 signaling,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16047 T29952 T30032 themeOf SOCS1,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16048 T30077 T30048 themeOf "IL-10-mediated STAT3 activation,","IL-10-mediated STAT3 activation,"
R16049 T30078 T30092 causeOf by SOCS1 induction in Th1 cells,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16050 T30079 T30091 causeOf by SOCS1 induction in Th1 cells,IL-4-induced STAT6 signaling is diminished by SOCS1 induction in Th1 cells
R16051 T29952 T30033 themeOf SOCS1,"SOCS1 and SOCS3 are induced by various cytokines, including IL-6 and IL-10, as mediators of negative feedback and crosstalk inhibition [7]"
R16052 T29956 T30035 causeOf impaired IL-10-dependent,"impaired IL-10-dependent STAT3 activation, in association with sustained STAT3 phosphorylation and SOCS1"
R16053 T30081 T30069 themeOf IL-12-induced STAT4 activation,"IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16054 T30081 T30070 themeOf IL-12-induced STAT4 activation,"IL-12-induced STAT4 activation is inhibited by SOCS3 induction in Th2 cells,"
R16055 T29956 T30061 themeOf impaired IL-10-dependent,impaired IL-10-dependent
R16056 T29959 T30114 themeOf STAT3,STAT3 activation
R16057 T29960 T30063 themeOf impaired IL-10-mediated,impaired IL-10-mediated
R16058 T30093 T30049 themeOf STAT3 activation,IL-10 may persistently stimulate STAT3 activation
R16059 T29960 T30076 causeOf impaired IL-10-mediated,with impaired IL-10-mediated STAT3 activation
R16060 T29961 T30062 themeOf of intracellular IL-10R1,of intracellular IL-10R1
R16061 T30097 T30047 themeOf "for impaired IL-10 signaling in the ST,","for impaired IL-10 signaling in the ST,"
R16062 T29965 T30111 themeOf STAT3 but not STAT1 phosphorylation,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R16063 T29965 T30112 themeOf STAT3 but not STAT1 phosphorylation,Serum IL-6 from RA patients induces STAT3 but not STAT1 phosphorylation in normal CD4+ T cells
R16064 T29976 T30104 themeOf STAT3,STAT3 activation has been shown to be involved in synovial fibroblast proliferation and IL-6 production [37]
R16065 T30106 T30098 themeOf This impaired IL-10 signaling,This impaired IL-10 signaling
R16066 T30107 T30100 themeOf gp130-mediated STAT3 activation,gp130-mediated STAT3 activation
R16067 T29979 T30099 themeOf of the CD28 molecule,the tyrosine phosphorylation of the CD28 molecule
R16068 T29985 T30037 themeOf CD28,CD28 costimulation
R16644 T31517 T31541 themeOf STAT3,of IL-6-dependent STAT3 activation
R16645 T31518 T31551 themeOf IFN-γ,"of IFN-γ production,"
R16646 T31524 T31545 themeOf of the SOCS3 gene,"the induction of the SOCS3 gene,"
R16647 T31524 T31546 themeOf of the SOCS3 gene,"the induction of the SOCS3 gene,"
R16648 T31525 T31544 themeOf STAT3,IL-10-mediated STAT3 activation
R16649 T31527 T31543 causeOf IL-6-dependent,of IL-6-dependent STAT3 activation
R16650 T31528 T31540 themeOf STAT3,STAT3 activation
R16651 T31530 T31548 causeOf IL-10,"IL-10 inhibition of IFN-γ production, due to constitutive STAT3 phosphorylation"
R16652 T31531 T31547 themeOf STAT3,constitutive STAT3 phosphorylation
R16653 T31535 T31549 causeOf IL-10-mediated,IL-10-mediated STAT3 activation
R16654 T31536 T31550 causeOf STAT3,The defective STAT3 signaling
R16655 T31541 T31542 themeOf of IL-6-dependent STAT3 activation,the inhibition of IL-6-dependent STAT3 activation
R16656 T31541 T31543 themeOf of IL-6-dependent STAT3 activation,of IL-6-dependent STAT3 activation
R16657 T31544 T31549 themeOf IL-10-mediated STAT3 activation,IL-10-mediated STAT3 activation
R16658 T31551 T31548 themeOf "of IFN-γ production,","IL-10 inhibition of IFN-γ production, due to constitutive STAT3 phosphorylation"
R3098 T6199 T6347 themeOf gene,gene transcription
R3099 T6173 T6340 causeOf CD4+ T cells,"In addition, CD4+ T cells could stimulate B-cell production of autoantibodies such as rheumatoid factor"
R3100 T6200 T6360 themeOf of autoantibodies,B-cell production of autoantibodies such as
R3101 T6208 T6356 themeOf IL-10R1,which are constitutively associated with IL-10R1 and type 2 IL-10R
R3102 T6179 T6373 themeOf granulocyte–macrophage colony-stimulating factor [15],granulocyte–macrophage colony-stimulating factor [15]
R3103 T6180 T6371 themeOf cell surface CD69,cell surface CD69
R3104 T6183 T6352 themeOf CD86,binding to CD80 and CD86 with high avidity [23]
R3105 T6215 T6354 themeOf IL-10,The interaction of IL-10 and IL-10R
R3106 T6189 T6351 themeOf of IL-10R1,Cell surface expression of IL-10R1
R3107 T6191 T6369 themeOf STAT3,shown that STAT3 activation
R3108 T6216 T6374 themeOf of the latent transcriptional factors signal transducer and activator of transcription (STAT) 3,activation of the latent transcriptional factors signal transducer and activator of transcription (STAT) 3
R3109 T6217 T6365 themeOf "IL-10, produced by macrophages","IL-10, produced by macrophages"
R3110 T6219 T6354 themeOf IL-10R,The interaction of IL-10 and IL-10R
R3111 T6221 T6353 themeOf STAT3,STAT3 activation induced by IL-6 but not that induced by IL-10
R3112 T6223 T6366 themeOf SOCS3,the expression of SOCS1 and SOCS3
R3113 T6226 T6357 themeOf of IFN-γ,investigated the production of IFN-γ
R3114 T6260 T6373 locationOf granulocyte–macrophage,granulocyte–macrophage colony-stimulating factor [15]
R3115 T6229 T6350 causeOf CD28-mediated,"CD28-mediated costimulatory signaling, in RA"
R3116 T6261 T6367 themeOf SOCS1,the expression of SOCS1 and SOCS3
R3117 T6233 T6340 themeOf B-cell production of autoantibodies such as rheumatoid factor,"In addition, CD4+ T cells could stimulate B-cell production of autoantibodies such as rheumatoid factor"
R3118 T6265 T6342 causeOf IL-10,IL-10 signaling
R3119 T6267 T6372 causeOf IL-6-mediated,responsible for IL-6-mediated prevention of apoptosis
R3120 T6234 T6355 themeOf type 2 IL-10R,which are constitutively associated with IL-10R1 and type 2 IL-10R
R3121 T6235 T6358 themeOf Numerous cytokines,Numerous cytokines are overproduced in the inflamed joint
R3122 T6235 T6359 themeOf Numerous cytokines,Numerous cytokines are overproduced in the inflamed joint
R3123 T6250 T6345 causeOf STAT1,"STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription"
R3124 T6284 T6363 themeOf STAT3,the induction of STAT1 and STAT3
R3125 T6284 T6364 themeOf STAT3,the induction of STAT1 and STAT3
R3126 T6285 T6370 causeOf osteoclast-mediated,osteoclast-mediated bone destruction
R3127 T6292 T6352 themeOf CD80,binding to CD80 and CD86 with high avidity [23]
R3128 T6304 T6349 themeOf component type 1 IL-10R (IL-10R1),the primary ligand-binding component type 1 IL-10R (IL-10R1)
R3129 T6299 T6348 themeOf CD28,CD28 costimulation
R3130 T6306 T6346 themeOf to the IL-10 receptor (IL-10R) complex,IL-10 binds to the IL-10 receptor (IL-10R) complex
R3131 T6309 T6361 themeOf STAT1,the induction of STAT1 and STAT3
R3132 T6353 T6341 themeOf STAT3 activation induced by IL-6 but not that induced by IL-10,by specifically blocking STAT3 activation induced by IL-6 but not that induced by IL-10
R3133 T6309 T6362 themeOf STAT1,the induction of STAT1 and STAT3
R3134 T6311 T6344 causeOf STAT3 proteins,"STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription"
R3135 T6322 T6346 themeOf IL-10,IL-10 binds to the IL-10 receptor (IL-10R) complex
R3136 T6338 T6371 locationOf cell surface,cell surface CD69
R3141 T6342 T6368 themeOf IL-10 signaling,IL-10 signaling is impaired in macrophages upon chronic exposure to proinflammatory cytokines such as TNF-α and IL-1
R3144 T6347 T6344 themeOf gene transcription,"STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription"
R3147 T6347 T6345 themeOf gene transcription,"STAT1 and STAT3 proteins form homodimers or heterodimers, rapidly translocate into the nucleus, and modulate gene transcription"
R4655 T8969 T8978 themeOf IL-10R1,IL-10R1 expression
R5460 T10522 T10535 themeOf β-actin,β-actin expression
R612 T1871 T1907 themeOf the antigen-specific T-cell cytokine response,the antigen-specific T-cell cytokine response
R613 T1872 T1918 causeOf T cells with IL-6,T cells with IL-6 reduced IL-10-mediated inhibition of interferon gamma production
R614 T1873 T1911 causeOf IL-10-mediated,IL-10-mediated inhibition of interferon gamma production
R615 T1876 T1914 themeOf signal transducer and activator of transcription 3,signal transducer and activator of transcription 3 phosphorylation in normal CD4+ T cells
R616 T1878 T1909 causeOf IL-10,this impaired IL-10 signaling
R617 T1881 T1907 locationOf T-cell,the antigen-specific T-cell cytokine response
R618 T1884 T1912 themeOf anti-IL-6 antibody,neutralizing anti-IL-6 antibody
R619 T1885 T1906 themeOf CD28,CD28 costimulation
R6194 T11831 T11890 themeOf STAT3,"Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,"
R6195 T11838 T11889 themeOf STAT,on STAT phosphorylation
R6196 T11845 T11892 themeOf STAT,STAT phosphorylation was compared with the total amount of STAT protein
R6197 T11866 T11888 causeOf of serum IL-6,"To examine the effect of serum IL-6 on STAT phosphorylation,"
R6198 T11874 T11891 themeOf STAT1,"Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,"
R6199 T11887 T11874 partOf Tyrosine,STAT1
R620 T1895 T1916 themeOf suppressor of cytokine signaling 1,suppressor of cytokine signaling 1 induction
R6200 T11887 T11831 partOf Tyrosine,STAT3
R6201 T11887 T11890 siteOf Tyrosine,"Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,"
R6202 T11887 T11891 siteOf Tyrosine,"Tyrosine phosphorylation of STAT1 and STAT3 was detected using commercial available kits (Cell Signaling Technology,"
R6203 T11889 T11888 themeOf on STAT phosphorylation,"To examine the effect of serum IL-6 on STAT phosphorylation,"
R621 T1895 T1917 themeOf suppressor of cytokine signaling 1,suppressor of cytokine signaling 1 induction
R622 T1897 T1913 themeOf signal transducer and activator of transcription 3,sustained signal transducer and activator of transcription 3 activation
R623 T1900 T1908 themeOf of suppressor of cytokine signaling 1,expression of suppressor of cytokine signaling 1 in CD4
R624 T1902 T1910 themeOf of signal transducer and activator of transcription 3,The phosphorylation of signal transducer and activator of transcription 3
R625 T1909 T1915 themeOf this impaired IL-10 signaling,this impaired IL-10 signaling
R7392 T14269 T14338 themeOf IFN-γ,on IFN-γ production
R7393 T14280 T14343 themeOf CD28,CD28 costimulation
R7394 T14286 T14341 themeOf IFN-γ,IFN-γ production by CD4+ T cells
R7395 T14296 T14349 causeOf of IL-10,effect of IL-10 on IFN-γ production
R7396 T14297 T14339 themeOf CD28,CD28 costimulation
R7397 T14303 T14344 themeOf IL-2,"In addition, we compared IL-2 production by CD4+ T cells after CD3 and CD28 costimulation"
R7398 T14304 T14350 themeOf IFN-γ,IFN-γ production
R7399 T14307 T14345 themeOf IL-2,IL-2 production
R7400 T14320 T14346 themeOf IFN-γ,IFN-γ production without IL-10 among these three groups
R7401 T14324 T14348 themeOf IFN-γ,IFN-γ production by activated normal CD4+ T cells
R7402 T14326 T14336 themeOf IFN-γ,of IFN-γ production
R7403 T14331 T14347 causeOf by 1 ng/ml IL-10,"IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease,"
R7404 T14335 T14340 causeOf IL-10,IL-10 inhibition of IFN-γ production in RA CD4+ T cells
R7405 T14336 T14340 themeOf of IFN-γ production,IL-10 inhibition of IFN-γ production in RA CD4+ T cells
R7406 T14338 T14349 themeOf on IFN-γ production,effect of IL-10 on IFN-γ production
R7407 T14345 T14347 themeOf IL-2 production,"IL-2 production was not affected by 1 ng/ml IL-10 in RA patients (percentage decrease,"
R7408 T14349 T14337 themeOf effect of IL-10 on IFN-γ production,effect of IL-10 on IFN-γ production was significantly limited in the active RA group
R7786 T15257 T15283 themeOf of cell surface IL-10R1 on RA CD4+ T cells,of cell surface IL-10R1 on RA CD4+ T cells
R7787 T15259 T15283 locationOf cell surface,of cell surface IL-10R1 on RA CD4+ T cells
R7788 T15268 T15284 themeOf IL-10R1,of IL-10R1 expression
R7789 T15272 T15285 themeOf IL-10,IL-10 inhibition
R7790 T15274 T15287 themeOf receptor,"limited receptor expression,"
R7791 T15276 T15286 themeOf IL-10R1,IL-10R1 expression
R7792 T15287 T15288 themeOf "limited receptor expression,","limited receptor expression,"
R8651 T16947 T17019 themeOf the major IL-10-activated STAT in CD4+ T cells,the major IL-10-activated STAT in CD4+ T cells
R8652 T16947 T17012 themeOf the major IL-10-activated STAT in CD4+ T cells,the major IL-10-activated STAT in CD4+ T cells
R8653 T16948 T17018 themeOf of the latent transcription factors STAT1,activation of the latent transcription factors STAT1
R8654 T16949 T17010 causeOf Defective IL-10,Defective IL-10-mediated STAT3 phosphorylation in RA CD4+ T cells
R8655 T16957 T17014 themeOf STAT3,this STAT3 phosphorylation
R8656 T16958 T17019 locationOf CD4+ T cells,the major IL-10-activated STAT in CD4+ T cells
R8657 T16960 T17006 themeOf of IL-10R,The interaction of IL-10R with IL-10
R8658 T16963 T17017 themeOf negative STAT3,of dominant-negative STAT3 overexpression [30]
R8659 T16963 T17016 themeOf negative STAT3,of dominant-negative STAT3 overexpression [30]
R8660 T16965 T17003 themeOf STAT3,defective IL-10-induced STAT3 phosphorylation
R8661 T16968 T17007 themeOf STAT3,STAT3 phosphorylation in RA CD4+ T cells
R8662 T16971 T17008 themeOf STAT3,"In contrast, STAT3 was phosphorylated in freshly isolated PB CD4+ cells"
R8663 T16978 T17012 causeOf major IL-10-activated,the major IL-10-activated STAT in CD4+ T cells
R8664 T16981 T17006 themeOf with IL-10,The interaction of IL-10R with IL-10
R8665 T16982 T17005 themeOf STAT3,STAT3 phosphorylation
R8666 T16985 T17002 themeOf STAT3,STAT3 phosphorylation
R8667 T16987 T17013 themeOf IL-10,IL-10 activation for 20
R8668 T16988 T17011 themeOf STAT3,with sustained STAT3 phosphorylation
R8669 T16989 T17015 themeOf STAT3,IL-10-induced STAT3 activation
R8670 T16990 T17020 themeOf STAT3,STAT3 phosphorylation
R8671 T16991 T17004 themeOf STAT3,STAT3 phosphorylation
R8672 T16996 T17009 themeOf STAT1,"On the other hand, IL-10-induced STAT1 phosphorylation was not detected in either RA CD4+ T cells or normal CD4+ T cells"
R8673 T17007 T17010 themeOf STAT3 phosphorylation in RA CD4+ T cells,Defective IL-10-mediated STAT3 phosphorylation in RA CD4+ T cells