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PMC:3586680 / 1079-6633 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2503 58-70 NNP denotes Glioblastoma
T2504 71-81 JJ denotes multiforme
T2505 82-90 VBZ denotes afflicts
T2506 91-97 CD denotes 12,500
T2507 98-101 JJ denotes new
T2508 102-110 NNS denotes patients
T2509 111-113 IN denotes in
T2510 114-117 DT denotes the
T2511 118-122 NNP denotes U.S.
T2512 123-131 RB denotes annually
T2513 132-133 -LRB- denotes (
T2514 133-141 NNP denotes Friedman
T2515 142-144 FW denotes et
T2516 145-148 FW denotes al.
T2517 148-149 , denotes ,
T2518 150-154 CD denotes 2000
T2519 154-155 : denotes ;
T2520 156-161 NNP denotes Stupp
T2521 162-164 FW denotes et
T2522 165-168 FW denotes al.
T2523 168-169 , denotes ,
T2524 170-174 CD denotes 2009
T2525 174-175 : denotes ;
T2526 176-182 NNP denotes Silber
T2527 183-185 FW denotes et
T2528 186-189 FW denotes al.
T2529 189-190 , denotes ,
T2530 191-195 CD denotes 2012
T2531 195-196 -RRB- denotes )
T2532 196-197 . denotes .
T2533 198-210 NNP denotes Glioblastoma
T2534 211-212 -LRB- denotes (
T2535 212-215 NNP denotes GBM
T2536 215-216 -RRB- denotes )
T2537 217-219 VBZ denotes is
T2538 220-226 RB denotes highly
T2539 227-233 JJ denotes lethal
T2540 233-234 , denotes ,
T2541 235-238 CC denotes and
T2542 239-242 DT denotes the
T2543 243-250 JJ denotes average
T2544 251-259 NN denotes survival
T2545 260-270 NN denotes expectancy
T2546 271-273 VBZ denotes is
T2547 274-278 CD denotes 14.6
T2548 279-285 NNS denotes months
T2549 285-286 , denotes ,
T2550 287-290 CC denotes and
T2551 291-294 DT denotes the
T2552 295-302 JJ denotes overall
T2553 303-309 JJ denotes 5-year
T2554 310-318 NN denotes survival
T2555 319-323 NN denotes rate
T2556 324-327 IN denotes for
T2557 328-331 NNP denotes GBM
T2558 332-334 VBZ denotes is
T2559 335-339 RB denotes only
T2560 340-343 CD denotes 9.8
T2561 343-344 NN denotes %
T2562 345-346 -LRB- denotes (
T2563 346-354 NNP denotes Friedman
T2564 355-357 FW denotes et
T2565 358-361 FW denotes al.
T2566 361-362 , denotes ,
T2567 363-367 CD denotes 2000
T2568 367-368 : denotes ;
T2569 369-374 NNP denotes Stupp
T2570 375-377 FW denotes et
T2571 378-381 FW denotes al.
T2572 381-382 , denotes ,
T2573 383-387 CD denotes 2009
T2574 387-388 -RRB- denotes )
T2575 388-389 . denotes .
T2576 390-394 JJ denotes High
T2577 395-401 NNS denotes levels
T2578 402-404 IN denotes of
T2579 405-415 NN denotes resistance
T2580 416-418 TO denotes to
T2581 419-426 JJ denotes current
T2582 427-438 JJ denotes therapeutic
T2583 439-449 NNS denotes modalities
T2584 450-453 CC denotes and
T2585 454-460 NN denotes cancer
T2586 461-468 NN denotes relapse
T2587 469-472 VBP denotes are
T2588 473-483 RB denotes frequently
T2589 484-488 VBN denotes seen
T2590 489-491 IN denotes in
T2591 492-500 NNS denotes patients
T2592 501-502 -LRB- denotes (
T2593 502-506 NNP denotes Haar
T2594 507-509 FW denotes et
T2595 510-513 FW denotes al.
T2596 513-514 , denotes ,
T2597 515-519 CD denotes 2012
T2598 519-520 : denotes ;
T2599 521-528 NNP denotes Happold
T2600 529-531 FW denotes et
T2601 532-535 FW denotes al.
T2602 535-536 , denotes ,
T2603 537-541 CD denotes 2012
T2604 541-542 -RRB- denotes )
T2605 542-543 . denotes .
T2606 544-547 DT denotes The
T2607 548-555 JJ denotes current
T2608 556-564 JJ denotes standard
T2609 565-572 NN denotes therapy
T2610 573-576 IN denotes for
T2611 577-580 NNP denotes GBM
T2612 581-587 RB denotes mainly
T2613 588-596 VBZ denotes includes
T2614 597-604 NN denotes maximum
T2615 605-614 NN denotes debulking
T2616 615-622 NN denotes surgery
T2617 622-623 , denotes ,
T2618 624-633 NN denotes radiation
T2619 633-634 , denotes ,
T2620 635-638 CC denotes and
T2621 639-648 NN denotes treatment
T2622 649-653 IN denotes with
T2623 654-657 DT denotes the
T2624 658-672 JJ denotes monofunctional
T2625 673-683 NN denotes alkylating
T2626 684-689 NN denotes agent
T2627 690-702 NN denotes temozolomide
T2628 703-704 -LRB- denotes (
T2629 704-707 NNP denotes TMZ
T2630 707-708 -RRB- denotes )
T2631 709-710 -LRB- denotes (
T2632 710-718 NNP denotes Friedman
T2633 719-721 FW denotes et
T2634 722-725 FW denotes al.
T2635 725-726 , denotes ,
T2636 727-731 CD denotes 2000
T2637 731-732 : denotes ;
T2638 733-742 NNP denotes Nishikawa
T2639 742-743 , denotes ,
T2640 744-748 CD denotes 2010
T2641 748-749 -RRB- denotes )
T2642 749-750 . denotes .
T2643 751-759 JJ denotes Multiple
T2644 760-770 NNS denotes mechanisms
T2645 771-774 VBP denotes are
T2646 775-783 VBN denotes involved
T2647 784-786 IN denotes in
T2648 787-790 DT denotes the
T2649 791-794 NNP denotes TMZ
T2650 795-805 NN denotes resistance
T2651 805-806 , denotes ,
T2652 807-812 WDT denotes which
T2653 813-816 MD denotes may
T2654 817-824 VB denotes include
T2655 825-831 NN denotes cancer
T2656 832-836 NN denotes stem
T2657 837-842 NNS denotes cells
T2658 842-843 , denotes ,
T2659 844-853 NNS denotes microRNAs
T2660 853-854 , denotes ,
T2661 855-859 NN denotes drug
T2662 860-866 NN denotes efflux
T2663 866-867 , denotes ,
T2664 868-871 NNP denotes DNA
T2665 872-878 NN denotes damage
T2666 879-885 NN denotes repair
T2667 885-886 , denotes ,
T2668 887-892 NN denotes tumor
T2669 893-898 NNS denotes cells
T2670 899-904 IN denotes under
T2671 905-912 NN denotes hypoxia
T2672 912-913 , denotes ,
T2673 914-921 NN denotes histone
T2674 922-935 NN denotes deacetylation
T2675 935-936 , denotes ,
T2676 937-959 JJ denotes epithelial-mesenchymal
T2677 960-970 NN denotes transition
T2678 970-971 , denotes ,
T2679 972-977 CD denotes STAT3
T2680 978-984 NN denotes kinase
T2681 984-985 , denotes ,
T2682 986-989 CC denotes and
T2683 990-994 JJ denotes many
T2684 995-1001 NNS denotes others
T2685 1002-1003 -LRB- denotes (
T2686 1003-1007 NNP denotes Haar
T2687 1008-1010 FW denotes et
T2688 1011-1014 FW denotes al.
T2689 1014-1015 , denotes ,
T2690 1016-1020 CD denotes 2012
T2691 1020-1021 : denotes ;
T2692 1022-1029 NNP denotes Happold
T2693 1030-1032 FW denotes et
T2694 1033-1036 FW denotes al.
T2695 1036-1037 , denotes ,
T2696 1038-1042 CD denotes 2012
T2697 1042-1043 : denotes ;
T2698 1044-1055 NNP denotes Johannessen
T2699 1056-1059 CC denotes and
T2700 1060-1068 NNP denotes Bjerkvig
T2701 1068-1069 , denotes ,
T2702 1070-1074 CD denotes 2012
T2703 1074-1075 : denotes ;
T2704 1076-1083 NNP denotes Kitange
T2705 1084-1086 FW denotes et
T2706 1087-1090 FW denotes al.
T2707 1090-1091 , denotes ,
T2708 1092-1096 CD denotes 2012
T2709 1096-1097 : denotes ;
T2710 1098-1105 NNP denotes Kohsaka
T2711 1106-1108 FW denotes et
T2712 1109-1112 FW denotes al.
T2713 1112-1113 , denotes ,
T2714 1114-1118 CD denotes 2012
T2715 1118-1119 : denotes ;
T2716 1120-1125 NNP denotes Zhang
T2717 1126-1128 FW denotes et
T2718 1129-1132 FW denotes al.
T2719 1132-1133 , denotes ,
T2720 1134-1139 JJ denotes 2012b
T2721 1139-1140 -RRB- denotes )
T2722 1140-1141 . denotes .
T2723 1142-1154 NNP denotes Temozolomide
T2724 1155-1162 VBZ denotes induces
T2725 1163-1173 NN denotes generation
T2726 1174-1176 IN denotes of
T2727 1177-1180 NNP denotes DNA
T2728 1181-1188 NNS denotes lesions
T2729 1188-1189 , denotes ,
T2730 1190-1199 VBG denotes including
T2731 1200-1216 NNP denotes O6-methylguanine
T2732 1216-1217 , denotes ,
T2733 1218-1234 NNP denotes N3-methyladenine
T2734 1234-1235 , denotes ,
T2735 1236-1239 CC denotes and
T2736 1240-1256 NNP denotes N7-methylguanine
T2737 1257-1258 -LRB- denotes (
T2738 1258-1266 NNP denotes Goellner
T2739 1267-1269 FW denotes et
T2740 1270-1273 FW denotes al.
T2741 1273-1274 , denotes ,
T2742 1275-1279 CD denotes 2011
T2743 1279-1280 : denotes ;
T2744 1281-1286 NNP denotes Zhang
T2745 1287-1289 FW denotes et
T2746 1290-1293 FW denotes al.
T2747 1293-1294 , denotes ,
T2748 1295-1300 JJ denotes 2012b
T2749 1300-1301 -RRB- denotes )
T2750 1301-1302 . denotes .
T2751 1303-1306 DT denotes The
T2752 1307-1323 JJ denotes O6-methylguanine
T2753 1324-1330 NN denotes lesion
T2754 1331-1333 VBZ denotes is
T2755 1334-1339 VBN denotes known
T2756 1340-1342 TO denotes to
T2757 1343-1350 VB denotes trigger
T2758 1351-1360 NN denotes autophagy
T2759 1360-1361 , denotes ,
T2760 1362-1368 RB denotes rather
T2761 1369-1373 IN denotes than
T2762 1374-1383 NN denotes apoptosis
T2763 1383-1384 , denotes ,
T2764 1385-1387 TO denotes to
T2765 1388-1393 VB denotes cause
T2766 1394-1398 NN denotes cell
T2767 1399-1404 NN denotes death
T2768 1405-1406 -LRB- denotes (
T2769 1406-1413 NNP denotes Kanzawa
T2770 1414-1416 FW denotes et
T2771 1417-1420 FW denotes al.
T2772 1420-1421 , denotes ,
T2773 1422-1426 CD denotes 2003
T2774 1426-1427 -RRB- denotes )
T2775 1427-1428 . denotes .
T2776 1429-1433 RB denotes Also
T2777 1433-1434 , denotes ,
T2778 1435-1445 NN denotes inhibition
T2779 1446-1448 IN denotes of
T2780 1449-1462 JJ denotes antiapoptotic
T2781 1463-1468 NN denotes Bcl-2
T2782 1469-1471 IN denotes by
T2783 1472-1473 DT denotes a
T2784 1474-1483 NN denotes pan-Bcl-2
T2785 1484-1493 NN denotes inhibitor
T2786 1494-1495 -LRB- denotes (
T2787 1495-1496 FW denotes −
T2788 1496-1497 -RRB- denotes )
T2789 1497-1498 : denotes -
T2790 1498-1506 NN denotes gossypol
T2791 1507-1512 VBZ denotes leads
T2792 1513-1515 TO denotes to
T2793 1516-1526 JJ denotes autophagic
T2794 1527-1532 NN denotes death
T2795 1533-1535 IN denotes in
T2796 1536-1543 NNS denotes gliomas
T2797 1544-1547 CC denotes and
T2798 1548-1556 VBZ denotes enhances
T2799 1557-1560 DT denotes the
T2800 1561-1567 NN denotes action
T2801 1568-1570 IN denotes of
T2802 1571-1574 NNP denotes TMZ
T2803 1575-1576 -LRB- denotes (
T2804 1576-1580 NNP denotes Voss
T2805 1581-1583 FW denotes et
T2806 1584-1587 FW denotes al.
T2807 1587-1588 , denotes ,
T2808 1589-1593 CD denotes 2010
T2809 1593-1594 -RRB- denotes )
T2810 1594-1595 . denotes .
T2811 1596-1603 RB denotes However
T2812 1603-1604 , denotes ,
T2813 1605-1606 DT denotes a
T2814 1607-1613 JJ denotes recent
T2815 1614-1619 NN denotes study
T2816 1620-1632 VBD denotes demonstrated
T2817 1633-1637 IN denotes that
T2818 1638-1649 JJ denotes TMZ-induced
T2819 1650-1659 NN denotes autophagy
T2820 1660-1662 VBZ denotes is
T2821 1663-1675 JJ denotes pro-survival
T2822 1675-1676 , denotes ,
T2823 1677-1680 CC denotes and
T2824 1681-1684 MD denotes may
T2825 1685-1690 VB denotes block
T2826 1691-1694 DT denotes the
T2827 1695-1703 JJ denotes eventual
T2828 1704-1713 NN denotes apoptosis
T2829 1714-1716 IN denotes in
T2830 1717-1720 NNP denotes GBM
T2831 1721-1726 NNS denotes cells
T2832 1727-1728 -LRB- denotes (
T2833 1728-1736 NNP denotes Knizhnik
T2834 1737-1739 FW denotes et
T2835 1740-1743 FW denotes al.
T2836 1743-1744 , denotes ,
T2837 1745-1749 CD denotes 2013
T2838 1749-1750 -RRB- denotes )
T2839 1750-1751 . denotes .
T2840 1752-1756 RB denotes Also
T2841 1756-1757 , denotes ,
T2842 1758-1763 NNP denotes MAPO2
T2843 1764-1765 -LRB- denotes (
T2844 1765-1773 NNP denotes C1orf201
T2845 1773-1774 -RRB- denotes )
T2846 1775-1779 NN denotes gene
T2847 1780-1792 VBZ denotes participates
T2848 1793-1795 IN denotes in
T2849 1796-1799 DT denotes the
T2850 1800-1816 JJ denotes O6-methylguanine
T2851 1817-1831 JJ denotes lesion-induced
T2852 1832-1841 NN denotes apoptosis
T2853 1842-1843 -LRB- denotes (
T2854 1843-1851 NNP denotes Fujikane
T2855 1852-1854 FW denotes et
T2856 1855-1858 FW denotes al.
T2857 1858-1859 , denotes ,
T2858 1860-1864 CD denotes 2012
T2859 1864-1865 -RRB- denotes )
T2860 1865-1866 . denotes .
T2861 1867-1872 CD denotes MAPO2
T2862 1873-1877 NN denotes gene
T2863 1878-1885 VBZ denotes encodes
T2864 1886-1887 DT denotes a
T2865 1888-1893 NN denotes novel
T2866 1894-1900 NN denotes 37-kDa
T2867 1901-1908 NN denotes protein
T2868 1908-1909 . denotes .
T2869 1910-1912 PRP denotes It
T2870 1913-1915 VBZ denotes is
T2871 1916-1919 RB denotes not
T2872 1920-1930 VBN denotes determined
T2873 1931-1938 IN denotes whether
T2874 1939-1943 DT denotes this
T2875 1944-1948 NN denotes gene
T2876 1949-1951 VBZ denotes is
T2877 1952-1960 VBN denotes involved
T2878 1961-1963 IN denotes in
T2879 1964-1973 NN denotes autophagy
T2880 1973-1974 . denotes .
T2881 1975-1978 DT denotes The
T2882 1979-1995 JJ denotes O6-methylguanine
T2883 1996-2002 NN denotes lesion
T2884 2003-2005 VBZ denotes is
T2885 2006-2007 DT denotes a
T2886 2008-2017 NN denotes substrate
T2887 2018-2021 IN denotes for
T2888 2022-2028 JJ denotes direct
T2889 2029-2035 NN denotes repair
T2890 2036-2038 IN denotes by
T2891 2039-2059 NNP denotes O6-methylguanine-DNA
T2892 2060-2077 NN denotes methyltransferase
T2893 2078-2079 -LRB- denotes (
T2894 2079-2083 NNP denotes MGMT
T2895 2083-2084 -RRB- denotes )
T2896 2085-2086 -LRB- denotes (
T2897 2086-2093 NNP denotes Pollack
T2898 2094-2096 FW denotes et
T2899 2097-2100 FW denotes al.
T2900 2100-2101 , denotes ,
T2901 2102-2106 CD denotes 2006
T2902 2106-2107 : denotes ;
T2903 2108-2112 NNP denotes Hegi
T2904 2113-2115 FW denotes et
T2905 2116-2119 FW denotes al.
T2906 2119-2120 , denotes ,
T2907 2121-2125 CD denotes 2008
T2908 2125-2126 : denotes ;
T2909 2127-2136 NNP denotes Fukushima
T2910 2137-2139 FW denotes et
T2911 2140-2143 FW denotes al.
T2912 2143-2144 , denotes ,
T2913 2145-2149 CD denotes 2009
T2914 2149-2150 : denotes ;
T2915 2151-2156 NNP denotes Zhang
T2916 2157-2159 FW denotes et
T2917 2160-2163 FW denotes al.
T2918 2163-2164 , denotes ,
T2919 2165-2170 JJ denotes 2012b
T2920 2170-2171 -RRB- denotes )
T2921 2171-2172 . denotes .
T2922 2173-2180 IN denotes Without
T2923 2181-2185 NNP denotes MGMT
T2924 2186-2192 NN denotes repair
T2925 2192-2193 , denotes ,
T2926 2194-2210 JJ denotes O6-methylguanine
T2927 2211-2220 NNS denotes initiates
T2928 2221-2231 NN denotes activation
T2929 2232-2234 IN denotes of
T2930 2235-2243 NN denotes mismatch
T2931 2244-2260 NN denotes repair-deficient
T2932 2261-2262 -LRB- denotes (
T2933 2262-2265 NNP denotes MMR
T2934 2265-2266 -RRB- denotes )
T2935 2267-2275 NNS denotes proteins
T2936 2276-2278 CC denotes or
T2937 2279-2291 JJ denotes Rad3-related
T2938 2292-2299 NN denotes protein
T2939 2300-2306 NN denotes kinase
T2940 2307-2311 WDT denotes that
T2941 2312-2322 RB denotes ultimately
T2942 2323-2328 VBZ denotes leads
T2943 2329-2331 TO denotes to
T2944 2332-2341 JJ denotes apoptotic
T2945 2342-2346 NN denotes cell
T2946 2347-2352 NN denotes death
T2947 2353-2354 -LRB- denotes (
T2948 2354-2362 NNP denotes Caporali
T2949 2363-2365 FW denotes et
T2950 2366-2369 FW denotes al.
T2951 2369-2370 , denotes ,
T2952 2371-2375 CD denotes 2004
T2953 2375-2376 : denotes ;
T2954 2377-2381 NNP denotes Wang
T2955 2382-2385 CC denotes and
T2956 2386-2394 NNP denotes Edelmann
T2957 2394-2395 , denotes ,
T2958 2396-2400 CD denotes 2006
T2959 2400-2401 : denotes ;
T2960 2402-2406 NNP denotes Roos
T2961 2407-2409 FW denotes et
T2962 2410-2413 FW denotes al.
T2963 2413-2414 , denotes ,
T2964 2415-2419 CD denotes 2007
T2965 2419-2420 -RRB- denotes )
T2966 2420-2421 . denotes .
T2967 2422-2426 NNP denotes High
T2968 2427-2437 NN denotes expression
T2969 2438-2440 IN denotes of
T2970 2441-2445 NNP denotes MGMT
T2971 2446-2448 CC denotes or
T2972 2449-2453 NN denotes loss
T2973 2454-2456 IN denotes of
T2974 2457-2460 NNP denotes MMR
T2975 2461-2472 VBZ denotes contributes
T2976 2473-2486 RB denotes significantly
T2977 2487-2489 TO denotes to
T2978 2490-2493 NNP denotes TMZ
T2979 2494-2504 NN denotes resistance
T2980 2505-2507 IN denotes in
T2981 2508-2512 JJ denotes many
T2982 2513-2521 JJ denotes clinical
T2983 2522-2527 NNS denotes cases
T2984 2528-2529 -LRB- denotes (
T2985 2529-2536 NNP denotes Pollack
T2986 2537-2539 FW denotes et
T2987 2540-2543 FW denotes al.
T2988 2543-2544 , denotes ,
T2989 2545-2549 CD denotes 2006
T2990 2549-2550 : denotes ;
T2991 2551-2555 NNP denotes Hegi
T2992 2556-2558 FW denotes et
T2993 2559-2562 FW denotes al.
T2994 2562-2563 , denotes ,
T2995 2564-2568 CD denotes 2008
T2996 2568-2569 : denotes ;
T2997 2570-2578 NNP denotes Sarkaria
T2998 2579-2581 FW denotes et
T2999 2582-2585 FW denotes al.
T3000 2585-2586 , denotes ,
T3001 2587-2591 CD denotes 2008
T3002 2591-2592 -RRB- denotes )
T3003 2592-2593 . denotes .
T3004 2594-2597 DT denotes The
T3005 2598-2608 NN denotes initiation
T3006 2609-2611 IN denotes of
T3007 2612-2621 JJ denotes apoptotic
T3008 2622-2631 VBG denotes signaling
T3009 2632-2637 VBZ denotes fails
T3010 2638-2640 IN denotes in
T3011 2641-2644 DT denotes the
T3012 2645-2652 NN denotes absence
T3013 2653-2655 IN denotes of
T3014 2656-2659 DT denotes the
T3015 2660-2663 NNP denotes MMR
T3016 2664-2670 NN denotes system
T3017 2670-2671 . denotes .
T3018 2672-2683 NN denotes Sensitivity
T3019 2684-2686 TO denotes to
T3020 2687-2690 NNP denotes TMZ
T3021 2691-2693 VBZ denotes is
T3022 2694-2707 RB denotes significantly
T3023 2708-2718 VBN denotes associated
T3024 2719-2723 IN denotes with
T3025 2724-2727 DT denotes the
T3026 2728-2739 NN denotes methylation
T3027 2740-2746 NN denotes status
T3028 2747-2749 IN denotes of
T3029 2750-2754 NNP denotes MGMT
T3030 2755-2759 NN denotes gene
T3031 2760-2768 NN denotes promoter
T3032 2769-2771 IN denotes in
T3033 2772-2777 NNS denotes cells
T3034 2778-2787 VBN denotes committed
T3035 2788-2790 TO denotes to
T3036 2791-2806 NN denotes differentiation
T3037 2807-2808 -LRB- denotes (
T3038 2808-2816 NNP denotes Villalva
T3039 2817-2819 FW denotes et
T3040 2820-2823 FW denotes al.
T3041 2823-2824 , denotes ,
T3042 2825-2829 CD denotes 2012
T3043 2829-2830 -RRB- denotes )
T3044 2830-2831 . denotes .
T3045 2832-2834 DT denotes An
T3046 2835-2843 NN denotes increase
T3047 2844-2846 IN denotes in
T3048 2847-2851 NNP denotes MGMT
T3049 2852-2856 NN denotes gene
T3050 2857-2865 NN denotes promoter
T3051 2866-2877 NN denotes methylation
T3052 2877-2878 , denotes ,
T3053 2879-2884 WDT denotes which
T3054 2885-2891 VBZ denotes blocks
T3055 2892-2896 NNP denotes MGMT
T3056 2897-2904 NN denotes protein
T3057 2905-2915 NN denotes expression
T3058 2915-2916 , denotes ,
T3059 2917-2925 VBZ denotes prolongs
T3060 2926-2932 NN denotes cancer
T3061 2933-2940 NN denotes patient
T3062 2941-2949 NN denotes survival
T3063 2949-2950 . denotes .
T3064 2951-2963 RB denotes Intriguingly
T3065 2963-2964 , denotes ,
T3066 2965-2978 VBD denotes overexpressed
T3067 2979-2990 NN denotes microRNA-21
T3068 2991-2998 VBZ denotes reduces
T3069 2999-3006 NNP denotes Bax/Bcl
T3070 3006-3008 CD denotes -2
T3071 3009-3014 NN denotes ratio
T3072 3015-3018 CC denotes and
T3073 3019-3028 JJ denotes caspase-3
T3074 3029-3037 NN denotes activity
T3075 3037-3038 , denotes ,
T3076 3039-3046 RB denotes thereby
T3077 3047-3055 VBG denotes blocking
T3078 3056-3067 JJ denotes TMZ-induced
T3079 3068-3077 NN denotes apoptosis
T3080 3078-3079 -LRB- denotes (
T3081 3079-3082 NNP denotes Shi
T3082 3083-3085 FW denotes et
T3083 3086-3089 FW denotes al.
T3084 3089-3090 , denotes ,
T3085 3091-3095 CD denotes 2010
T3086 3095-3096 -RRB- denotes )
T3087 3096-3097 . denotes .
T3088 3098-3109 NN denotes MicroRNA-21
T3089 3110-3112 VBZ denotes is
T3090 3113-3123 VBN denotes considered
T3091 3124-3126 IN denotes as
T3092 3127-3128 DT denotes a
T3093 3129-3141 JJ denotes pro-survival
T3094 3142-3148 NN denotes factor
T3095 3149-3152 IN denotes for
T3096 3153-3159 NN denotes cancer
T3097 3160-3165 NNS denotes cells
T3098 3166-3167 -LRB- denotes (
T3099 3167-3169 NNP denotes Li
T3100 3170-3172 FW denotes et
T3101 3173-3176 FW denotes al.
T3102 3176-3177 , denotes ,
T3103 3178-3182 CD denotes 2012
T3104 3182-3183 -RRB- denotes )
T3105 3183-3184 . denotes .
T3106 3185-3194 NNS denotes Integrins
T3107 3195-3199 VBP denotes play
T3108 3200-3201 DT denotes a
T3109 3202-3206 NN denotes role
T3110 3207-3209 IN denotes in
T3111 3210-3213 DT denotes the
T3112 3214-3224 NN denotes resistance
T3113 3225-3227 IN denotes of
T3114 3228-3236 JJ denotes advanced
T3115 3237-3244 NNS denotes cancers
T3116 3245-3247 TO denotes to
T3117 3248-3260 JJ denotes radiotherapy
T3118 3261-3264 CC denotes and
T3119 3265-3277 JJ denotes chemotherapy
T3120 3277-3278 . denotes .
T3121 3279-3283 JJ denotes α5β1
T3122 3284-3292 NN denotes integrin
T3123 3293-3303 RB denotes negatively
T3124 3304-3313 VBZ denotes regulates
T3125 3314-3317 NN denotes p53
T3126 3318-3327 VBG denotes signaling
T3127 3327-3328 , denotes ,
T3128 3329-3332 CC denotes and
T3129 3333-3336 DT denotes the
T3130 3337-3342 NN denotes event
T3131 3343-3350 VBZ denotes induces
T3132 3351-3357 NN denotes glioma
T3133 3358-3362 NN denotes cell
T3134 3363-3373 NN denotes resistance
T3135 3374-3376 TO denotes to
T3136 3377-3380 NNP denotes TMZ
T3137 3381-3382 -LRB- denotes (
T3138 3382-3392 NNP denotes Janouskova
T3139 3393-3395 FW denotes et
T3140 3396-3399 FW denotes al.
T3141 3399-3400 , denotes ,
T3142 3401-3405 CD denotes 2012
T3143 3405-3406 -RRB- denotes )
T3144 3406-3407 . denotes .
T3145 3408-3412 JJ denotes α5β1
T3146 3413-3421 NN denotes integrin
T3147 3422-3424 VBZ denotes is
T3148 3425-3435 VBN denotes considered
T3149 3436-3438 IN denotes as
T3150 3439-3440 DT denotes a
T3151 3441-3452 JJ denotes therapeutic
T3152 3453-3459 NN denotes target
T3153 3460-3463 IN denotes for
T3154 3464-3474 JJ denotes high-grade
T3155 3475-3480 NN denotes brain
T3156 3481-3487 NNS denotes tumors
T3157 3487-3488 . denotes .
T3158 3489-3492 DT denotes The
T3159 3493-3497 NN denotes base
T3160 3498-3506 NN denotes excision
T3161 3507-3513 NN denotes repair
T3162 3514-3520 NN denotes enzyme
T3163 3521-3550 JJ denotes alkylpurine-DNA-N-glycosylase
T3164 3551-3552 -LRB- denotes (
T3165 3552-3556 NNP denotes APNG
T3166 3556-3557 -RRB- denotes )
T3167 3557-3558 , denotes ,
T3168 3559-3564 WDT denotes which
T3169 3565-3572 NNS denotes repairs
T3170 3573-3576 DT denotes the
T3171 3577-3586 JJ denotes cytotoxic
T3172 3587-3594 NNS denotes lesions
T3173 3595-3611 JJ denotes N3-methyladenine
T3174 3612-3615 CC denotes and
T3175 3616-3632 JJ denotes N7-methylguanine
T3176 3632-3633 , denotes ,
T3177 3634-3638 RB denotes also
T3178 3639-3651 VBZ denotes participates
T3179 3652-3654 IN denotes in
T3180 3655-3658 DT denotes the
T3181 3659-3662 NNP denotes TMZ
T3182 3663-3673 NN denotes resistance
T3183 3674-3675 -LRB- denotes (
T3184 3675-3684 NNP denotes Agnihotri
T3185 3685-3687 FW denotes et
T3186 3688-3691 FW denotes al.
T3187 3691-3692 , denotes ,
T3188 3693-3697 CD denotes 2012
T3189 3697-3698 -RRB- denotes )
T3190 3698-3699 . denotes .
T3191 3700-3712 NNP denotes Upregulation
T3192 3713-3715 IN denotes of
T3193 3716-3729 JJ denotes mitochondrial
T3194 3730-3741 JJ denotes respiratory
T3195 3742-3747 NN denotes chain
T3196 3748-3756 NN denotes coupling
T3197 3757-3759 TO denotes to
T3198 3760-3768 VB denotes suppress
T3199 3769-3772 DT denotes the
T3200 3773-3783 NN denotes production
T3201 3784-3786 IN denotes of
T3202 3787-3795 JJ denotes reactive
T3203 3796-3802 NN denotes oxygen
T3204 3803-3810 NNS denotes species
T3205 3811-3812 -LRB- denotes (
T3206 3812-3815 NNP denotes ROS
T3207 3815-3816 -RRB- denotes )
T3208 3817-3826 VBN denotes regulated
T3209 3827-3829 IN denotes by
T3210 3830-3840 NN denotes cytochrome
T3211 3841-3842 NN denotes c
T3212 3843-3850 NN denotes oxidase
T3213 3851-3862 VBZ denotes contributes
T3214 3863-3865 IN denotes in
T3215 3866-3870 NN denotes part
T3216 3871-3873 TO denotes to
T3217 3874-3877 NNP denotes TMZ
T3218 3878-3888 NN denotes resistance
T3219 3889-3891 IN denotes in
T3220 3892-3899 NNS denotes gliomas
T3221 3900-3901 -LRB- denotes (
T3222 3901-3906 NNP denotes Oliva
T3223 3907-3909 FW denotes et
T3224 3910-3913 FW denotes al.
T3225 3913-3914 , denotes ,
T3226 3915-3919 CD denotes 2011
T3227 3919-3920 -RRB- denotes )
T3228 3920-3921 . denotes .
T3229 3922-3930 NN denotes Reversal
T3230 3931-3933 IN denotes of
T3231 3934-3937 NNP denotes TMZ
T3232 3938-3948 NN denotes resistance
T3233 3949-3952 MD denotes may
T3234 3953-3955 VB denotes be
T3235 3956-3964 VBN denotes achieved
T3236 3965-3967 IN denotes by
T3237 3968-3972 NNP denotes MGMT
T3238 3973-3989 NNS denotes pseudosubstrates
T3239 3989-3990 , denotes ,
T3240 3991-4007 NN denotes O6-benzylguanine
T3241 4008-4011 CC denotes and
T3242 4012-4023 NN denotes lomeguatrib
T3243 4024-4026 TO denotes to
T3244 4027-4036 VB denotes sensitize
T3245 4037-4043 NNS denotes tumors
T3246 4044-4046 TO denotes to
T3247 4047-4050 NNP denotes TMZ
T3248 4051-4052 -LRB- denotes (
T3249 4052-4057 NNP denotes Zhang
T3250 4058-4060 FW denotes et
T3251 4061-4064 FW denotes al.
T3252 4064-4065 , denotes ,
T3253 4066-4071 JJ denotes 2012b
T3254 4071-4072 -RRB- denotes )
T3255 4072-4073 . denotes .
T3256 4074-4094 NN denotes Methoxyamine-blocker
T3257 4095-4097 IN denotes of
T3258 4098-4102 NN denotes base
T3259 4103-4111 NN denotes excision
T3260 4112-4118 NN denotes repair
T3261 4119-4130 VBZ denotes contributes
T3262 4131-4144 RB denotes significantly
T3263 4145-4147 TO denotes to
T3264 4148-4151 NNP denotes TMZ
T3265 4152-4164 NN denotes cytotoxicity
T3266 4165-4177 RB denotes particularly
T3267 4178-4182 WRB denotes when
T3268 4183-4199 JJ denotes O6-methylguanine
T3269 4200-4207 NNS denotes adducts
T3270 4208-4211 VBP denotes are
T3271 4212-4220 VBN denotes repaired
T3272 4221-4223 CC denotes or
T3273 4224-4233 VBN denotes tolerated
T3274 4234-4235 -LRB- denotes (
T3275 4235-4243 NNP denotes Goellner
T3276 4244-4246 FW denotes et
T3277 4247-4250 FW denotes al.
T3278 4250-4251 , denotes ,
T3279 4252-4256 CD denotes 2011
T3280 4256-4257 : denotes ;
T3281 4258-4263 NNP denotes Zhang
T3282 4264-4266 FW denotes et
T3283 4267-4270 FW denotes al.
T3284 4270-4271 , denotes ,
T3285 4272-4277 JJ denotes 2012b
T3286 4277-4278 -RRB- denotes )
T3287 4278-4279 . denotes .
T3288 4280-4284 JJ denotes Dual
T3289 4285-4294 VBG denotes targeting
T3290 4295-4297 IN denotes of
T3291 4298-4302 NN denotes base
T3292 4303-4311 NN denotes excision
T3293 4312-4318 NN denotes repair
T3294 4319-4322 CC denotes and
T3295 4323-4326 NNP denotes NAD
T3296 4326-4327 -LRB- denotes (
T3297 4327-4328 VBN denotes +
T3298 4328-4329 -RRB- denotes )
T3299 4330-4342 NN denotes biosynthesis
T3300 4343-4346 MD denotes may
T3301 4347-4354 VB denotes reverse
T3302 4355-4358 NNP denotes TMZ
T3303 4359-4369 NN denotes resistance
T3304 4370-4372 IN denotes in
T3305 4373-4381 NNS denotes patients
T3306 4382-4386 IN denotes with
T3307 4387-4396 JJ denotes resistant
T3308 4397-4400 CC denotes and
T3309 4401-4410 JJ denotes recurrent
T3310 4411-4414 NNP denotes GBM
T3311 4415-4416 -LRB- denotes (
T3312 4416-4424 NNP denotes Goellner
T3313 4425-4427 FW denotes et
T3314 4428-4431 FW denotes al.
T3315 4431-4432 , denotes ,
T3316 4433-4437 CD denotes 2011
T3317 4437-4438 -RRB- denotes )
T3318 4438-4439 . denotes .
T3319 4440-4452 NNP denotes Interferon-β
T3320 4453-4454 -LRB- denotes (
T3321 4454-4459 NNP denotes IFN-β
T3322 4459-4460 -RRB- denotes )
T3323 4460-4461 , denotes ,
T3324 4462-4475 NN denotes levetiracetam
T3325 4476-4477 -LRB- denotes (
T3326 4477-4480 NNP denotes LEV
T3327 4480-4481 -RRB- denotes )
T3328 4481-4482 , denotes ,
T3329 4483-4494 NN denotes resveratrol
T3330 4494-4495 , denotes ,
T3331 4496-4499 CC denotes and
T3332 4500-4508 JJ denotes valproic
T3333 4509-4513 NN denotes acid
T3334 4514-4515 -LRB- denotes (
T3335 4515-4518 NNP denotes VAP
T3336 4518-4519 -RRB- denotes )
T3337 4520-4528 VB denotes increase
T3338 4529-4532 DT denotes the
T3339 4533-4544 NN denotes sensitivity
T3340 4545-4547 IN denotes of
T3341 4548-4551 NNP denotes TMZ
T3342 4552-4559 IN denotes through
T3343 4560-4574 NNP denotes MGMT-dependent
T3344 4575-4577 CC denotes or
T3345 4578-4579 : denotes -
T3346 4579-4590 JJ denotes independent
T3347 4591-4601 NNS denotes mechanisms
T3348 4602-4603 -LRB- denotes (
T3349 4603-4609 NNP denotes Nakada
T3350 4610-4612 FW denotes et
T3351 4613-4616 FW denotes al.
T3352 4616-4617 , denotes ,
T3353 4618-4622 CD denotes 2012
T3354 4622-4623 -RRB- denotes )
T3355 4623-4624 . denotes .
T3356 4625-4636 NNP denotes Resveratrol
T3357 4636-4637 , denotes ,
T3358 4638-4639 DT denotes a
T3359 4640-4647 JJ denotes natural
T3360 4648-4658 NN denotes polyphenol
T3361 4658-4659 , denotes ,
T3362 4660-4668 VBZ denotes reverses
T3363 4669-4672 NNP denotes TMZ
T3364 4673-4683 NN denotes resistance
T3365 4684-4687 IN denotes via
T3366 4688-4690 DT denotes an
T3367 4691-4706 JJ denotes NF-κB-dependent
T3368 4707-4716 NN denotes mechanism
T3369 4717-4718 -LRB- denotes (
T3370 4718-4723 NNP denotes Huang
T3371 4724-4726 FW denotes et
T3372 4727-4730 FW denotes al.
T3373 4730-4731 , denotes ,
T3374 4732-4736 CD denotes 2012
T3375 4736-4737 -RRB- denotes )
T3376 4737-4738 . denotes .
T3377 4739-4744 CD denotes STAT3
T3378 4745-4754 NN denotes inhibitor
T3379 4755-4757 CC denotes or
T3380 4758-4763 CD denotes STAT3
T3381 4764-4773 JJ denotes knockdown
T3382 4774-4785 NNS denotes potentiates
T3383 4786-4789 NNP denotes TMZ
T3384 4790-4798 NN denotes efficacy
T3385 4799-4801 IN denotes in
T3386 4802-4811 JJ denotes resistant
T3387 4812-4815 NNP denotes GBM
T3388 4816-4820 NN denotes cell
T3389 4821-4826 NNS denotes lines
T3390 4827-4828 -LRB- denotes (
T3391 4828-4835 NNP denotes Kohsaka
T3392 4836-4838 FW denotes et
T3393 4839-4842 FW denotes al.
T3394 4842-4843 , denotes ,
T3395 4844-4848 CD denotes 2012
T3396 4848-4849 -RRB- denotes )
T3397 4849-4850 . denotes .
T3398 4851-4863 NNP denotes Intratumoral
T3399 4864-4871 NN denotes hypoxia
T3400 4872-4874 VBZ denotes is
T3401 4875-4881 JJ denotes common
T3402 4882-4884 IN denotes in
T3403 4885-4889 NNS denotes GBMs
T3404 4890-4893 CC denotes and
T3405 4894-4897 MD denotes may
T3406 4898-4900 VB denotes be
T3407 4901-4911 VBN denotes associated
T3408 4912-4916 IN denotes with
T3409 4917-4920 DT denotes the
T3410 4921-4932 NN denotes development
T3411 4933-4935 IN denotes of
T3412 4936-4939 NNP denotes TMZ
T3413 4940-4950 NN denotes resistance
T3414 4950-4951 . denotes .
T3415 4952-4959 VBN denotes Induced
T3416 4960-4969 NN denotes hyperoxia
T3417 4970-4973 MD denotes can
T3418 4974-4976 VB denotes be
T3419 4977-4985 VBN denotes utilized
T3420 4986-4988 TO denotes to
T3421 4989-4996 VB denotes reverse
T3422 4997-5000 NNP denotes TMZ
T3423 5001-5011 NN denotes resistance
T3424 5012-5014 IN denotes in
T3425 5015-5019 NNS denotes GBMs
T3426 5020-5021 -LRB- denotes (
T3427 5021-5024 NNP denotes Sun
T3428 5025-5027 FW denotes et
T3429 5028-5031 FW denotes al.
T3430 5031-5032 , denotes ,
T3431 5033-5037 CD denotes 2012
T3432 5037-5038 -RRB- denotes )
T3433 5038-5039 . denotes .
T3434 5040-5046 NNP denotes Cancer
T3435 5047-5051 NN denotes stem
T3436 5052-5057 NNS denotes cells
T3437 5058-5061 VBP denotes are
T3438 5062-5070 RB denotes probably
T3439 5071-5074 DT denotes the
T3440 5075-5078 NN denotes key
T3441 5079-5081 TO denotes to
T3442 5082-5089 NN denotes failure
T3443 5090-5092 IN denotes in
T3444 5093-5096 NNP denotes TMZ
T3445 5097-5106 NN denotes treatment
T3446 5106-5107 . denotes .
T3447 5108-5111 DT denotes The
T3448 5112-5119 NN denotes concept
T3449 5120-5122 IN denotes of
T3450 5123-5129 NN denotes cancer
T3451 5130-5134 NN denotes stem
T3452 5135-5139 NN denotes cell
T3453 5140-5148 NN denotes survival
T3454 5149-5153 IN denotes from
T3455 5154-5163 NN denotes treatment
T3456 5164-5168 IN denotes with
T3457 5169-5172 NNP denotes TMZ
T3458 5173-5176 CC denotes and
T3459 5177-5182 JJ denotes other
T3460 5183-5199 JJ denotes chemotherapeutic
T3461 5200-5205 NNS denotes drugs
T3462 5206-5209 VBZ denotes has
T3463 5210-5214 VBN denotes been
T3464 5215-5219 RBR denotes more
T3465 5220-5231 JJ denotes complicated
T3466 5232-5236 IN denotes than
T3467 5237-5247 RB denotes previously
T3468 5248-5255 VBN denotes thought
T3469 5256-5257 -LRB- denotes (
T3470 5257-5262 NNP denotes Beier
T3471 5263-5265 FW denotes et
T3472 5266-5269 FW denotes al.
T3473 5269-5270 , denotes ,
T3474 5271-5275 CD denotes 2011
T3475 5275-5276 : denotes ;
T3476 5277-5281 NNP denotes Chen
T3477 5282-5284 FW denotes et
T3478 5285-5288 FW denotes al.
T3479 5288-5289 , denotes ,
T3480 5290-5294 CD denotes 2012
T3481 5294-5295 -RRB- denotes )
T3482 5295-5296 . denotes .
T3483 5297-5311 JJ denotes CD133-positive
T3484 5312-5318 NN denotes cancer
T3485 5319-5323 NN denotes stem
T3486 5324-5329 NNS denotes cells
T3487 5330-5333 VBP denotes are
T3488 5334-5343 VBN denotes expressed
T3489 5344-5346 IN denotes in
T3490 5347-5351 DT denotes both
T3491 5352-5358 JJ denotes normal
T3492 5359-5363 NN denotes stem
T3493 5364-5369 NNS denotes cells
T3494 5370-5373 CC denotes and
T3495 5374-5380 NN denotes cancer
T3496 5381-5385 NN denotes stem
T3497 5386-5391 NNS denotes cells
T3498 5392-5393 -LRB- denotes (
T3499 5393-5400 NNP denotes Donovan
T3500 5401-5404 CC denotes and
T3501 5405-5415 NNP denotes Pilkington
T3502 5415-5416 , denotes ,
T3503 5417-5421 CD denotes 2012
T3504 5421-5422 -RRB- denotes )
T3505 5422-5423 . denotes .
T3506 5424-5431 RB denotes However
T3507 5431-5432 , denotes ,
T3508 5433-5436 DT denotes the
T3509 5437-5441 NN denotes role
T3510 5442-5444 IN denotes of
T3511 5445-5450 NNP denotes CD133
T3512 5451-5453 IN denotes as
T3513 5454-5455 DT denotes a
T3514 5456-5462 NN denotes marker
T3515 5463-5466 IN denotes for
T3516 5467-5473 NN denotes glioma
T3517 5474-5480 NN denotes cancer
T3518 5481-5485 NN denotes stem
T3519 5486-5491 NNS denotes cells
T3520 5492-5500 JJ denotes relative
T3521 5501-5503 TO denotes to
T3522 5504-5507 PRP$ denotes its
T3523 5508-5518 JJ denotes biological
T3524 5519-5527 NN denotes function
T3525 5528-5531 VBZ denotes has
T3526 5532-5535 RB denotes yet
T3527 5536-5538 TO denotes to
T3528 5539-5541 VB denotes be
T3529 5542-5553 VBN denotes established
T3530 5553-5554 . denotes .
R1576 T2518 T2516 npadvmod 2000,al.
R1577 T2519 T2516 punct ;,al.
R1578 T2520 T2522 compound Stupp,al.
R1579 T2521 T2522 compound et,al.
R1580 T2503 T2504 compound Glioblastoma,multiforme
R1581 T2522 T2505 prep al.,afflicts
R1582 T2504 T2505 nsubj multiforme,afflicts
R1583 T2505 T2528 ccomp afflicts,al.
R1584 T2523 T2522 punct ",",al.
R1585 T2506 T2508 nummod "12,500",patients
R1586 T2524 T2522 npadvmod 2009,al.
R1587 T2507 T2508 amod new,patients
R1588 T2508 T2505 dobj patients,afflicts
R1589 T2509 T2508 prep in,patients
R1590 T2510 T2511 det the,U.S.
R1591 T2525 T2528 punct ;,al.
R1592 T2511 T2509 pobj U.S.,in
R1593 T2512 T2505 advmod annually,afflicts
R1594 T2526 T2528 compound Silber,al.
R1595 T2527 T2528 compound et,al.
R1596 T2528 T2528 ROOT al.,al.
R1597 T2513 T2516 punct (,al.
R1598 T2529 T2528 punct ",",al.
R1599 T2514 T2516 nmod Friedman,al.
R1600 T2515 T2516 nmod et,al.
R1601 T2530 T2528 npadvmod 2012,al.
R1602 T2516 T2522 compound al.,al.
R1603 T2517 T2516 punct ",",al.
R1604 T2531 T2528 punct ),al.
R1605 T2532 T2528 punct .,al.
R1606 T2533 T2537 nsubj Glioblastoma,is
R1607 T2534 T2535 punct (,GBM
R1608 T2570 T2571 compound et,al.
R1609 T2571 T2558 attr al.,is
R1610 T2535 T2533 appos GBM,Glioblastoma
R1611 T2572 T2571 punct ",",al.
R1612 T2573 T2571 npadvmod 2009,al.
R1613 T2574 T2558 punct ),is
R1614 T2536 T2533 punct ),Glioblastoma
R1615 T2575 T2546 punct .,is
R1616 T2576 T2577 amod High,levels
R1617 T2537 T2537 ROOT is,is
R1618 T2577 T2589 nsubjpass levels,seen
R1619 T2578 T2577 prep of,levels
R1620 T2579 T2578 pobj resistance,of
R1621 T2538 T2539 advmod highly,lethal
R1622 T2580 T2579 prep to,resistance
R1623 T2581 T2583 amod current,modalities
R1624 T2582 T2583 amod therapeutic,modalities
R1625 T2539 T2537 acomp lethal,is
R1626 T2583 T2580 pobj modalities,to
R1627 T2584 T2583 cc and,modalities
R1628 T2585 T2586 compound cancer,relapse
R1629 T2586 T2583 conj relapse,modalities
R1630 T2540 T2537 punct ",",is
R1631 T2587 T2589 auxpass are,seen
R1632 T2588 T2589 advmod frequently,seen
R1633 T2541 T2537 cc and,is
R1634 T2589 T2601 ccomp seen,al.
R1635 T2542 T2545 det the,expectancy
R1636 T2590 T2589 prep in,seen
R1637 T2543 T2545 amod average,expectancy
R1638 T2591 T2590 pobj patients,in
R1639 T2544 T2545 compound survival,expectancy
R1640 T2545 T2546 nsubj expectancy,is
R1641 T2592 T2595 punct (,al.
R1642 T2546 T2537 conj is,is
R1643 T2593 T2595 nmod Haar,al.
R1644 T2594 T2595 nmod et,al.
R1645 T2595 T2601 dep al.,al.
R1646 T2547 T2548 nummod 14.6,months
R1647 T2596 T2595 punct ",",al.
R1648 T2597 T2595 npadvmod 2012,al.
R1649 T2548 T2546 attr months,is
R1650 T2598 T2601 punct ;,al.
R1651 T2599 T2601 compound Happold,al.
R1652 T2600 T2601 compound et,al.
R1653 T2549 T2546 punct ",",is
R1654 T2601 T2601 ROOT al.,al.
R1655 T2602 T2601 punct ",",al.
R1656 T2603 T2601 npadvmod 2012,al.
R1657 T2604 T2601 punct ),al.
R1658 T2605 T2601 punct .,al.
R1659 T2606 T2609 det The,therapy
R1660 T2550 T2546 cc and,is
R1661 T2607 T2609 amod current,therapy
R1662 T2608 T2609 amod standard,therapy
R1663 T2609 T2613 nsubj therapy,includes
R1664 T2551 T2555 det the,rate
R1665 T2610 T2609 prep for,therapy
R1666 T2611 T2610 pobj GBM,for
R1667 T2612 T2613 advmod mainly,includes
R1668 T2552 T2555 amod overall,rate
R1669 T2613 T2613 ROOT includes,includes
R1670 T2614 T2616 amod maximum,surgery
R1671 T2615 T2616 compound debulking,surgery
R1672 T2553 T2555 amod 5-year,rate
R1673 T2616 T2613 dobj surgery,includes
R1674 T2617 T2616 punct ",",surgery
R1675 T2618 T2616 conj radiation,surgery
R1676 T2554 T2555 compound survival,rate
R1677 T2619 T2618 punct ",",radiation
R1678 T2620 T2618 cc and,radiation
R1679 T2555 T2558 nsubj rate,is
R1680 T2621 T2618 conj treatment,radiation
R1681 T2622 T2616 prep with,surgery
R1682 T2623 T2626 det the,agent
R1683 T2624 T2626 amod monofunctional,agent
R1684 T2556 T2555 prep for,rate
R1685 T2625 T2626 amod alkylating,agent
R1686 T2626 T2627 compound agent,temozolomide
R1687 T2627 T2622 pobj temozolomide,with
R1688 T2557 T2556 pobj GBM,for
R1689 T2628 T2627 punct (,temozolomide
R1690 T2629 T2627 appos TMZ,temozolomide
R1691 T2558 T2546 conj is,is
R1692 T2630 T2627 punct ),temozolomide
R1693 T2631 T2634 punct (,al.
R1694 T2632 T2634 compound Friedman,al.
R1695 T2559 T2560 advmod only,9.8
R1696 T2633 T2634 nmod et,al.
R1697 T2634 T2638 compound al.,Nishikawa
R1698 T2560 T2561 nummod 9.8,%
R1699 T2635 T2634 punct ",",al.
R1700 T2636 T2634 dep 2000,al.
R1701 T2637 T2634 punct ;,al.
R1702 T2561 T2558 attr %,is
R1703 T2638 T2616 appos Nishikawa,surgery
R1704 T2639 T2638 punct ",",Nishikawa
R1705 T2640 T2638 npadvmod 2010,Nishikawa
R1706 T2641 T2638 punct ),Nishikawa
R1707 T2642 T2613 punct .,includes
R1708 T2643 T2644 amod Multiple,mechanisms
R1709 T2562 T2565 punct (,al.
R1710 T2644 T2646 nsubjpass mechanisms,involved
R1711 T2645 T2646 auxpass are,involved
R1712 T2646 T2718 ccomp involved,al.
R1713 T2647 T2646 prep in,involved
R1714 T2563 T2565 compound Friedman,al.
R1715 T2648 T2650 det the,resistance
R1716 T2649 T2650 compound TMZ,resistance
R1717 T2650 T2647 pobj resistance,in
R1718 T2564 T2565 nmod et,al.
R1719 T2651 T2650 punct ",",resistance
R1720 T2652 T2654 nsubj which,include
R1721 T2653 T2654 aux may,include
R1722 T2565 T2558 parataxis al.,is
R1723 T2654 T2650 relcl include,resistance
R1724 T2655 T2657 compound cancer,cells
R1725 T2656 T2657 compound stem,cells
R1726 T2566 T2565 punct ",",al.
R1727 T2657 T2654 dobj cells,include
R1728 T2658 T2657 punct ",",cells
R1729 T2659 T2657 conj microRNAs,cells
R1730 T2567 T2565 npadvmod 2000,al.
R1731 T2660 T2659 punct ",",microRNAs
R1732 T2661 T2662 compound drug,efflux
R1733 T2662 T2659 conj efflux,microRNAs
R1734 T2663 T2662 punct ",",efflux
R1735 T2568 T2558 punct ;,is
R1736 T2664 T2666 compound DNA,repair
R1737 T2665 T2666 compound damage,repair
R1738 T2666 T2662 conj repair,efflux
R1739 T2569 T2571 compound Stupp,al.
R1740 T2764 T2765 aux to,cause
R1741 T2667 T2666 punct ",",repair
R1742 T2668 T2669 compound tumor,cells
R1743 T2765 T2757 advcl cause,trigger
R1744 T2669 T2659 conj cells,microRNAs
R1745 T2766 T2767 compound cell,death
R1746 T2670 T2654 prep under,include
R1747 T2767 T2765 dobj death,cause
R1748 T2671 T2670 pobj hypoxia,under
R1749 T2768 T2765 punct (,cause
R1750 T2769 T2771 compound Kanzawa,al.
R1751 T2672 T2671 punct ",",hypoxia
R1752 T2770 T2771 nmod et,al.
R1753 T2673 T2674 compound histone,deacetylation
R1754 T2674 T2671 appos deacetylation,hypoxia
R1755 T2675 T2674 punct ",",deacetylation
R1756 T2676 T2677 amod epithelial-mesenchymal,transition
R1757 T2677 T2674 appos transition,deacetylation
R1758 T2678 T2677 punct ",",transition
R1759 T2679 T2680 nummod STAT3,kinase
R1760 T2771 T2765 advmod al.,cause
R1761 T2680 T2677 conj kinase,transition
R1762 T2681 T2680 punct ",",kinase
R1763 T2772 T2771 punct ",",al.
R1764 T2682 T2680 cc and,kinase
R1765 T2683 T2684 amod many,others
R1766 T2684 T2680 conj others,kinase
R1767 T2773 T2771 npadvmod 2003,al.
R1768 T2685 T2684 punct (,others
R1769 T2686 T2688 compound Haar,al.
R1770 T2687 T2688 nmod et,al.
R1771 T2774 T2771 punct ),al.
R1772 T2688 T2684 appos al.,others
R1773 T2689 T2688 punct ",",al.
R1774 T2775 T2755 punct .,known
R1775 T2690 T2688 npadvmod 2012,al.
R1776 T2691 T2684 punct ;,others
R1777 T2692 T2694 compound Happold,al.
R1778 T2776 T2791 advmod Also,leads
R1779 T2693 T2694 compound et,al.
R1780 T2694 T2684 conj al.,others
R1781 T2695 T2694 punct ",",al.
R1782 T2777 T2791 punct ",",leads
R1783 T2696 T2694 npadvmod 2012,al.
R1784 T2697 T2718 punct ;,al.
R1785 T2698 T2718 dep Johannessen,al.
R1786 T2778 T2791 nsubj inhibition,leads
R1787 T2699 T2698 cc and,Johannessen
R1788 T2700 T2698 conj Bjerkvig,Johannessen
R1789 T2701 T2700 punct ",",Bjerkvig
R1790 T2702 T2700 npadvmod 2012,Bjerkvig
R1791 T2779 T2778 prep of,inhibition
R1792 T2703 T2700 punct ;,Bjerkvig
R1793 T2704 T2706 compound Kitange,al.
R1794 T2705 T2706 compound et,al.
R1795 T2780 T2781 amod antiapoptotic,Bcl-2
R1796 T2706 T2700 conj al.,Bjerkvig
R1797 T2707 T2706 punct ",",al.
R1798 T2708 T2706 npadvmod 2012,al.
R1799 T2781 T2779 pobj Bcl-2,of
R1800 T2709 T2718 punct ;,al.
R1801 T2710 T2712 compound Kohsaka,al.
R1802 T2711 T2712 compound et,al.
R1803 T2782 T2778 prep by,inhibition
R1804 T2712 T2718 ccomp al.,al.
R1805 T2713 T2712 punct ",",al.
R1806 T2714 T2712 npadvmod 2012,al.
R1807 T2715 T2718 punct ;,al.
R1808 T2716 T2718 compound Zhang,al.
R1809 T2717 T2718 nmod et,al.
R1810 T2783 T2785 det a,inhibitor
R1811 T2718 T2718 ROOT al.,al.
R1812 T2719 T2720 punct ",",2012b
R1813 T2784 T2785 compound pan-Bcl-2,inhibitor
R1814 T2720 T2718 amod 2012b,al.
R1815 T2785 T2782 pobj inhibitor,by
R1816 T2721 T2720 punct ),2012b
R1817 T2722 T2718 punct .,al.
R1818 T2723 T2724 nsubj Temozolomide,induces
R1819 T2786 T2787 punct (,−
R1820 T2724 T2746 ccomp induces,al.
R1821 T2725 T2724 dobj generation,induces
R1822 T2787 T2785 appos −,inhibitor
R1823 T2726 T2725 prep of,generation
R1824 T2727 T2728 compound DNA,lesions
R1825 T2728 T2726 pobj lesions,of
R1826 T2729 T2728 punct ",",lesions
R1827 T2788 T2787 punct ),−
R1828 T2730 T2728 prep including,lesions
R1829 T2731 T2730 pobj O6-methylguanine,including
R1830 T2789 T2791 punct -,leads
R1831 T2732 T2731 punct ",",O6-methylguanine
R1832 T2733 T2731 conj N3-methyladenine,O6-methylguanine
R1833 T2734 T2733 punct ",",N3-methyladenine
R1834 T2790 T2791 nsubj gossypol,leads
R1835 T2735 T2733 cc and,N3-methyladenine
R1836 T2736 T2733 conj N7-methylguanine,N3-methyladenine
R1837 T2737 T2740 punct (,al.
R1838 T2791 T2791 ROOT leads,leads
R1839 T2738 T2740 compound Goellner,al.
R1840 T2739 T2740 nmod et,al.
R1841 T2740 T2731 appos al.,O6-methylguanine
R1842 T2792 T2791 prep to,leads
R1843 T2741 T2740 punct ",",al.
R1844 T2742 T2740 npadvmod 2011,al.
R1845 T2793 T2792 pobj autophagic,to
R1846 T2743 T2746 punct ;,al.
R1847 T2744 T2746 compound Zhang,al.
R1848 T2745 T2746 compound et,al.
R1849 T2794 T2793 dobj death,autophagic
R1850 T2746 T2746 ROOT al.,al.
R1851 T2747 T2748 punct ",",2012b
R1852 T2795 T2793 prep in,autophagic
R1853 T2748 T2746 amod 2012b,al.
R1854 T2796 T2795 pobj gliomas,in
R1855 T2749 T2748 punct ),2012b
R1856 T2750 T2746 punct .,al.
R1857 T2751 T2753 det The,lesion
R1858 T2752 T2753 amod O6-methylguanine,lesion
R1859 T2797 T2791 cc and,leads
R1860 T2753 T2755 nsubjpass lesion,known
R1861 T2754 T2755 auxpass is,known
R1862 T2755 T2755 ROOT known,known
R1863 T2798 T2791 conj enhances,leads
R1864 T2756 T2757 aux to,trigger
R1865 T2757 T2755 xcomp trigger,known
R1866 T2758 T2757 dobj autophagy,trigger
R1867 T2759 T2758 punct ",",autophagy
R1868 T2760 T2761 advmod rather,than
R1869 T2799 T2800 det the,action
R1870 T2761 T2757 prep than,trigger
R1871 T2762 T2761 pobj apoptosis,than
R1872 T2763 T2757 punct ",",trigger
R1873 T2800 T2798 dobj action,enhances
R1874 T2801 T2800 prep of,action
R1875 T2802 T2801 pobj TMZ,of
R1876 T2803 T2806 punct (,al.
R1877 T2861 T2863 dep MAPO2,encodes
R1878 T2862 T2863 nsubj gene,encodes
R1879 T2804 T2806 compound Voss,al.
R1880 T2863 T2863 ROOT encodes,encodes
R1881 T2864 T2867 det a,protein
R1882 T2865 T2867 compound novel,protein
R1883 T2805 T2806 nmod et,al.
R1884 T2866 T2867 compound 37-kDa,protein
R1885 T2867 T2863 dobj protein,encodes
R1886 T2806 T2800 appos al.,action
R1887 T2868 T2863 punct .,encodes
R1888 T2869 T2872 nsubjpass It,determined
R1889 T2870 T2872 auxpass is,determined
R1890 T2871 T2872 neg not,determined
R1891 T2807 T2806 punct ",",al.
R1892 T2872 T2872 ROOT determined,determined
R1893 T2873 T2876 mark whether,is
R1894 T2874 T2875 det this,gene
R1895 T2808 T2806 npadvmod 2010,al.
R1896 T2875 T2876 nsubj gene,is
R1897 T2809 T2798 punct ),enhances
R1898 T2810 T2791 punct .,leads
R1899 T2876 T2877 auxpass is,involved
R1900 T2877 T2872 xcomp involved,determined
R1901 T2811 T2816 advmod However,demonstrated
R1902 T2878 T2877 prep in,involved
R1903 T2879 T2878 pobj autophagy,in
R1904 T2812 T2816 punct ",",demonstrated
R1905 T2880 T2872 punct .,determined
R1906 T2881 T2883 det The,lesion
R1907 T2882 T2883 amod O6-methylguanine,lesion
R1908 T2883 T2884 nsubj lesion,is
R1909 T2884 T2884 ROOT is,is
R1910 T2885 T2886 det a,substrate
R1911 T2813 T2815 det a,study
R1912 T2886 T2884 attr substrate,is
R1913 T2887 T2886 prep for,substrate
R1914 T2888 T2889 amod direct,repair
R1915 T2814 T2815 amod recent,study
R1916 T2889 T2887 pobj repair,for
R1917 T2815 T2816 nsubj study,demonstrated
R1918 T2816 T2816 ROOT demonstrated,demonstrated
R1919 T2890 T2889 prep by,repair
R1920 T2817 T2820 mark that,is
R1921 T2891 T2892 compound O6-methylguanine-DNA,methyltransferase
R1922 T2892 T2890 pobj methyltransferase,by
R1923 T2893 T2894 punct (,MGMT
R1924 T2818 T2819 amod TMZ-induced,autophagy
R1925 T2894 T2892 appos MGMT,methyltransferase
R1926 T2895 T2884 punct ),is
R1927 T2819 T2820 nsubj autophagy,is
R1928 T2896 T2899 punct (,al.
R1929 T2897 T2899 compound Pollack,al.
R1930 T2898 T2899 nmod et,al.
R1931 T2820 T2816 ccomp is,demonstrated
R1932 T2899 T2905 compound al.,al.
R1933 T2900 T2899 punct ",",al.
R1934 T2901 T2899 npadvmod 2006,al.
R1935 T2821 T2820 acomp pro-survival,is
R1936 T2902 T2899 punct ;,al.
R1937 T2903 T2905 compound Hegi,al.
R1938 T2904 T2905 compound et,al.
R1939 T2822 T2820 punct ",",is
R1940 T2905 T2905 ROOT al.,al.
R1941 T2906 T2905 punct ",",al.
R1942 T2823 T2820 cc and,is
R1943 T2824 T2825 aux may,block
R1944 T2907 T2905 npadvmod 2008,al.
R1945 T2908 T2905 punct ;,al.
R1946 T2825 T2820 conj block,is
R1947 T2909 T2911 compound Fukushima,al.
R1948 T2910 T2911 nmod et,al.
R1949 T2911 T2905 conj al.,al.
R1950 T2826 T2828 det the,apoptosis
R1951 T2912 T2911 punct ",",al.
R1952 T2913 T2911 npadvmod 2009,al.
R1953 T2827 T2828 amod eventual,apoptosis
R1954 T2914 T2917 punct ;,al.
R1955 T2915 T2917 compound Zhang,al.
R1956 T2916 T2917 nmod et,al.
R1957 T2917 T2884 attr al.,is
R1958 T2918 T2919 punct ",",2012b
R1959 T2828 T2825 dobj apoptosis,block
R1960 T2919 T2917 amod 2012b,al.
R1961 T2920 T2919 punct ),2012b
R1962 T2921 T2884 punct .,is
R1963 T2922 T2927 prep Without,initiates
R1964 T2923 T2924 compound MGMT,repair
R1965 T2829 T2825 prep in,block
R1966 T2924 T2922 pobj repair,Without
R1967 T2925 T2927 punct ",",initiates
R1968 T2926 T2927 nsubj O6-methylguanine,initiates
R1969 T2927 T2927 ROOT initiates,initiates
R1970 T2830 T2831 compound GBM,cells
R1971 T2928 T2927 dobj activation,initiates
R1972 T2929 T2928 prep of,activation
R1973 T2930 T2929 pobj mismatch,of
R1974 T2931 T2928 conj repair-deficient,activation
R1975 T2831 T2829 pobj cells,in
R1976 T2932 T2931 punct (,repair-deficient
R1977 T2933 T2935 nmod MMR,proteins
R1978 T2934 T2935 punct ),proteins
R1979 T2935 T2931 appos proteins,repair-deficient
R1980 T2832 T2835 punct (,al.
R1981 T2936 T2935 cc or,proteins
R1982 T2937 T2939 amod Rad3-related,kinase
R1983 T2833 T2835 compound Knizhnik,al.
R1984 T2938 T2939 compound protein,kinase
R1985 T2939 T2935 conj kinase,proteins
R1986 T2940 T2942 nsubj that,leads
R1987 T2834 T2835 nmod et,al.
R1988 T2941 T2942 advmod ultimately,leads
R1989 T2942 T2939 relcl leads,kinase
R1990 T2943 T2942 prep to,leads
R1991 T2835 T2825 parataxis al.,block
R1992 T2944 T2946 amod apoptotic,death
R1993 T2945 T2946 compound cell,death
R1994 T2946 T2943 pobj death,to
R1995 T2836 T2835 punct ",",al.
R1996 T2947 T2950 punct (,al.
R1997 T2948 T2950 compound Caporali,al.
R1998 T2949 T2950 nmod et,al.
R1999 T2837 T2835 npadvmod 2013,al.
R2000 T2950 T2939 appos al.,kinase
R2001 T2951 T2950 punct ",",al.
R2002 T2952 T2950 npadvmod 2004,al.
R2003 T2838 T2835 punct ),al.
R2004 T2953 T2927 punct ;,initiates
R2005 T2839 T2816 punct .,demonstrated
R2006 T2954 T2927 conj Wang,initiates
R2007 T2955 T2954 cc and,Wang
R2008 T2956 T2954 conj Edelmann,Wang
R2009 T2957 T2956 punct ",",Edelmann
R2010 T2840 T2847 advmod Also,participates
R2011 T2841 T2847 punct ",",participates
R2012 T2842 T2847 nsubj MAPO2,participates
R2013 T2958 T2954 npadvmod 2006,Wang
R2014 T2959 T2954 punct ;,Wang
R2015 T2843 T2842 punct (,MAPO2
R2016 T2960 T2962 compound Roos,al.
R2017 T2961 T2962 nmod et,al.
R2018 T2844 T2842 appos C1orf201,MAPO2
R2019 T2962 T2954 conj al.,Wang
R2020 T2963 T2962 punct ",",al.
R2021 T2964 T2962 npadvmod 2007,al.
R2022 T2845 T2842 punct ),MAPO2
R2023 T2965 T2962 punct ),al.
R2024 T2966 T2927 punct .,initiates
R2025 T2967 T2968 compound High,expression
R2026 T2968 T2975 nsubj expression,contributes
R2027 T2846 T2847 nsubj gene,participates
R2028 T2969 T2968 prep of,expression
R2029 T2970 T2969 pobj MGMT,of
R2030 T2971 T2970 cc or,MGMT
R2031 T2847 T2847 ROOT participates,participates
R2032 T2972 T2968 conj loss,expression
R2033 T2973 T2972 prep of,loss
R2034 T2974 T2973 pobj MMR,of
R2035 T2848 T2847 prep in,participates
R2036 T2975 T2999 ccomp contributes,al.
R2037 T2976 T2975 advmod significantly,contributes
R2038 T2977 T2975 prep to,contributes
R2039 T2849 T2852 det the,apoptosis
R2040 T2978 T2979 compound TMZ,resistance
R2041 T2979 T2977 pobj resistance,to
R2042 T2980 T2975 prep in,contributes
R2043 T2850 T2852 amod O6-methylguanine,apoptosis
R2044 T2981 T2983 amod many,cases
R2045 T2982 T2983 amod clinical,cases
R2046 T2851 T2852 amod lesion-induced,apoptosis
R2047 T2983 T2980 pobj cases,in
R2048 T2984 T2987 punct (,al.
R2049 T2985 T2987 compound Pollack,al.
R2050 T2852 T2848 pobj apoptosis,in
R2051 T2986 T2987 nmod et,al.
R2052 T2853 T2856 punct (,al.
R2053 T2854 T2856 nmod Fujikane,al.
R2054 T2987 T2975 advcl al.,contributes
R2055 T2988 T2987 punct ",",al.
R2056 T2855 T2856 nmod et,al.
R2057 T2989 T2987 npadvmod 2006,al.
R2058 T2990 T2999 punct ;,al.
R2059 T2991 T2993 compound Hegi,al.
R2060 T2992 T2993 nmod et,al.
R2061 T2856 T2852 appos al.,apoptosis
R2062 T2993 T2999 ccomp al.,al.
R2063 T2994 T2993 punct ",",al.
R2064 T2857 T2856 punct ",",al.
R2065 T2995 T2993 npadvmod 2008,al.
R2066 T2858 T2856 npadvmod 2012,al.
R2067 T2996 T2999 punct ;,al.
R2068 T2997 T2999 compound Sarkaria,al.
R2069 T2998 T2999 nmod et,al.
R2070 T2859 T2856 punct ),al.
R2071 T2999 T2999 ROOT al.,al.
R2072 T3000 T2999 punct ",",al.
R2073 T3001 T2999 npadvmod 2008,al.
R2074 T2860 T2847 punct .,participates
R2075 T3002 T2999 punct ),al.
R2076 T3003 T2999 punct .,al.
R2077 T3004 T3005 det The,initiation
R2078 T3005 T3009 nsubj initiation,fails
R2079 T3055 T3057 compound MGMT,expression
R2080 T3006 T3005 prep of,initiation
R2081 T3007 T3008 amod apoptotic,signaling
R2082 T3008 T3006 pobj signaling,of
R2083 T3009 T3009 ROOT fails,fails
R2084 T3010 T3009 prep in,fails
R2085 T3056 T3057 compound protein,expression
R2086 T3011 T3012 det the,absence
R2087 T3012 T3010 pobj absence,in
R2088 T3013 T3012 prep of,absence
R2089 T3057 T3054 dobj expression,blocks
R2090 T3014 T3016 det the,system
R2091 T3015 T3016 compound MMR,system
R2092 T3016 T3013 pobj system,of
R2093 T3058 T3059 punct ",",prolongs
R2094 T3017 T3009 punct .,fails
R2095 T3018 T3023 nsubjpass Sensitivity,associated
R2096 T3019 T3018 prep to,Sensitivity
R2097 T3059 T3059 ROOT prolongs,prolongs
R2098 T3020 T3019 pobj TMZ,to
R2099 T3060 T3062 compound cancer,survival
R2100 T3061 T3062 compound patient,survival
R2101 T3021 T3023 auxpass is,associated
R2102 T3022 T3023 advmod significantly,associated
R2103 T3062 T3059 dobj survival,prolongs
R2104 T3023 T3023 ROOT associated,associated
R2105 T3024 T3023 prep with,associated
R2106 T3025 T3027 det the,status
R2107 T3026 T3027 amod methylation,status
R2108 T3027 T3024 pobj status,with
R2109 T3028 T3027 prep of,status
R2110 T3063 T3059 punct .,prolongs
R2111 T3029 T3031 compound MGMT,promoter
R2112 T3030 T3031 compound gene,promoter
R2113 T3031 T3028 pobj promoter,of
R2114 T3064 T3068 advmod Intriguingly,reduces
R2115 T3032 T3027 prep in,status
R2116 T3033 T3032 pobj cells,in
R2117 T3065 T3068 punct ",",reduces
R2118 T3034 T3033 acl committed,cells
R2119 T3035 T3034 prep to,committed
R2120 T3036 T3035 pobj differentiation,to
R2121 T3066 T3067 amod overexpressed,microRNA-21
R2122 T3037 T3040 punct (,al.
R2123 T3038 T3040 compound Villalva,al.
R2124 T3039 T3040 nmod et,al.
R2125 T3067 T3068 nsubj microRNA-21,reduces
R2126 T3040 T3027 appos al.,status
R2127 T3041 T3040 punct ",",al.
R2128 T3042 T3040 npadvmod 2012,al.
R2129 T3068 T3068 ROOT reduces,reduces
R2130 T3043 T3023 punct ),associated
R2131 T3044 T3023 punct .,associated
R2132 T3045 T3046 det An,increase
R2133 T3069 T3071 nmod Bax/Bcl,ratio
R2134 T3046 T3059 nsubj increase,prolongs
R2135 T3047 T3046 prep in,increase
R2136 T3048 T3051 compound MGMT,methylation
R2137 T3070 T3069 nummod -2,Bax/Bcl
R2138 T3049 T3050 compound gene,promoter
R2139 T3050 T3051 compound promoter,methylation
R2140 T3051 T3047 pobj methylation,in
R2141 T3071 T3068 dobj ratio,reduces
R2142 T3052 T3051 punct ",",methylation
R2143 T3053 T3054 nsubj which,blocks
R2144 T3054 T3051 relcl blocks,methylation
R2145 T3072 T3071 cc and,ratio
R2146 T3073 T3074 amod caspase-3,activity
R2147 T3074 T3071 conj activity,ratio
R2148 T3152 T3149 pobj target,as
R2149 T3153 T3152 prep for,target
R2150 T3075 T3068 punct ",",reduces
R2151 T3154 T3156 amod high-grade,tumors
R2152 T3155 T3156 compound brain,tumors
R2153 T3076 T3077 advmod thereby,blocking
R2154 T3156 T3153 pobj tumors,for
R2155 T3157 T3148 punct .,considered
R2156 T3158 T3162 det The,enzyme
R2157 T3159 T3162 amod base,enzyme
R2158 T3160 T3162 compound excision,enzyme
R2159 T3161 T3162 compound repair,enzyme
R2160 T3162 T3178 nsubj enzyme,participates
R2161 T3077 T3068 advcl blocking,reduces
R2162 T3163 T3162 amod alkylpurine-DNA-N-glycosylase,enzyme
R2163 T3164 T3165 punct (,APNG
R2164 T3165 T3163 appos APNG,alkylpurine-DNA-N-glycosylase
R2165 T3078 T3079 amod TMZ-induced,apoptosis
R2166 T3166 T3165 punct ),APNG
R2167 T3167 T3163 punct ",",alkylpurine-DNA-N-glycosylase
R2168 T3079 T3077 dobj apoptosis,blocking
R2169 T3168 T3169 nsubj which,repairs
R2170 T3080 T3083 punct (,al.
R2171 T3169 T3163 relcl repairs,alkylpurine-DNA-N-glycosylase
R2172 T3170 T3172 det the,lesions
R2173 T3081 T3083 compound Shi,al.
R2174 T3171 T3172 amod cytotoxic,lesions
R2175 T3172 T3169 dobj lesions,repairs
R2176 T3173 T3169 advmod N3-methyladenine,repairs
R2177 T3082 T3083 nmod et,al.
R2178 T3174 T3173 cc and,N3-methyladenine
R2179 T3083 T3083 ROOT al.,al.
R2180 T3175 T3173 conj N7-methylguanine,N3-methyladenine
R2181 T3176 T3178 punct ",",participates
R2182 T3084 T3083 punct ",",al.
R2183 T3177 T3178 advmod also,participates
R2184 T3178 T3178 ROOT participates,participates
R2185 T3179 T3178 prep in,participates
R2186 T3085 T3083 npadvmod 2010,al.
R2187 T3180 T3182 det the,resistance
R2188 T3181 T3182 compound TMZ,resistance
R2189 T3182 T3179 pobj resistance,in
R2190 T3086 T3083 punct ),al.
R2191 T3183 T3186 punct (,al.
R2192 T3184 T3186 nmod Agnihotri,al.
R2193 T3185 T3186 nmod et,al.
R2194 T3087 T3083 punct .,al.
R2195 T3186 T3178 dep al.,participates
R2196 T3187 T3186 punct ",",al.
R2197 T3188 T3186 npadvmod 2012,al.
R2198 T3088 T3090 nsubjpass MicroRNA-21,considered
R2199 T3189 T3186 punct ),al.
R2200 T3190 T3178 punct .,participates
R2201 T3191 T3191 ROOT Upregulation,Upregulation
R2202 T3089 T3090 auxpass is,considered
R2203 T3192 T3191 prep of,Upregulation
R2204 T3193 T3196 amod mitochondrial,coupling
R2205 T3090 T3090 ROOT considered,considered
R2206 T3194 T3195 amod respiratory,chain
R2207 T3195 T3196 compound chain,coupling
R2208 T3196 T3192 pobj coupling,of
R2209 T3091 T3090 prep as,considered
R2210 T3092 T3094 det a,factor
R2211 T3197 T3198 aux to,suppress
R2212 T3198 T3191 advcl suppress,Upregulation
R2213 T3093 T3094 amod pro-survival,factor
R2214 T3199 T3200 det the,production
R2215 T3200 T3198 dobj production,suppress
R2216 T3094 T3091 pobj factor,as
R2217 T3201 T3200 prep of,production
R2218 T3202 T3204 amod reactive,species
R2219 T3203 T3204 compound oxygen,species
R2220 T3095 T3094 prep for,factor
R2221 T3204 T3201 pobj species,of
R2222 T3205 T3208 punct (,regulated
R2223 T3206 T3208 dep ROS,regulated
R2224 T3096 T3097 compound cancer,cells
R2225 T3207 T3208 punct ),regulated
R2226 T3097 T3095 pobj cells,for
R2227 T3208 T3198 advcl regulated,suppress
R2228 T3098 T3101 punct (,al.
R2229 T3209 T3208 agent by,regulated
R2230 T3210 T3212 compound cytochrome,oxidase
R2231 T3211 T3212 compound c,oxidase
R2232 T3099 T3101 compound Li,al.
R2233 T3212 T3209 pobj oxidase,by
R2234 T3213 T3208 punct contributes,regulated
R2235 T3100 T3101 nmod et,al.
R2236 T3214 T3213 prep in,contributes
R2237 T3215 T3214 pobj part,in
R2238 T3216 T3215 prep to,part
R2239 T3101 T3094 appos al.,factor
R2240 T3217 T3218 compound TMZ,resistance
R2241 T3218 T3216 pobj resistance,to
R2242 T3219 T3218 prep in,resistance
R2243 T3102 T3101 punct ",",al.
R2244 T3220 T3219 pobj gliomas,in
R2245 T3221 T3224 punct (,al.
R2246 T3222 T3224 compound Oliva,al.
R2247 T3103 T3101 npadvmod 2012,al.
R2248 T3223 T3224 nmod et,al.
R2249 T3224 T3208 dep al.,regulated
R2250 T3104 T3101 punct ),al.
R2251 T3225 T3224 punct ",",al.
R2252 T3226 T3224 npadvmod 2011,al.
R2253 T3227 T3224 punct ),al.
R2254 T3105 T3090 punct .,considered
R2255 T3228 T3191 punct .,Upregulation
R2256 T3229 T3235 nsubjpass Reversal,achieved
R2257 T3230 T3229 prep of,Reversal
R2258 T3231 T3230 pobj TMZ,of
R2259 T3232 T3235 nsubjpass resistance,achieved
R2260 T3233 T3235 aux may,achieved
R2261 T3106 T3107 nsubj Integrins,play
R2262 T3234 T3235 auxpass be,achieved
R2263 T3235 T3235 ROOT achieved,achieved
R2264 T3236 T3235 agent by,achieved
R2265 T3107 T3107 ROOT play,play
R2266 T3237 T3238 compound MGMT,pseudosubstrates
R2267 T3238 T3236 pobj pseudosubstrates,by
R2268 T3239 T3238 punct ",",pseudosubstrates
R2269 T3108 T3109 det a,role
R2270 T3240 T3238 conj O6-benzylguanine,pseudosubstrates
R2271 T3241 T3240 cc and,O6-benzylguanine
R2272 T3109 T3107 dobj role,play
R2273 T3242 T3240 conj lomeguatrib,O6-benzylguanine
R2274 T3243 T3244 aux to,sensitize
R2275 T3244 T3235 xcomp sensitize,achieved
R2276 T3245 T3244 dobj tumors,sensitize
R2277 T3110 T3109 prep in,role
R2278 T3246 T3244 prep to,sensitize
R2279 T3111 T3112 det the,resistance
R2280 T3247 T3246 pobj TMZ,to
R2281 T3112 T3110 pobj resistance,in
R2282 T3113 T3112 prep of,resistance
R2283 T3248 T3251 punct (,al.
R2284 T3114 T3115 amod advanced,cancers
R2285 T3115 T3113 pobj cancers,of
R2286 T3249 T3251 compound Zhang,al.
R2287 T3250 T3251 nmod et,al.
R2288 T3116 T3117 aux to,radiotherapy
R2289 T3251 T3246 parataxis al.,to
R2290 T3252 T3251 punct ",",al.
R2291 T3253 T3251 amod 2012b,al.
R2292 T3117 T3115 relcl radiotherapy,cancers
R2293 T3254 T3251 punct ),al.
R2294 T3255 T3235 punct .,achieved
R2295 T3118 T3117 cc and,radiotherapy
R2296 T3119 T3117 conj chemotherapy,radiotherapy
R2297 T3256 T3261 nsubj Methoxyamine-blocker,contributes
R2298 T3120 T3107 punct .,play
R2299 T3257 T3256 prep of,Methoxyamine-blocker
R2300 T3258 T3260 compound base,repair
R2301 T3259 T3260 compound excision,repair
R2302 T3121 T3122 amod α5β1,integrin
R2303 T3260 T3257 pobj repair,of
R2304 T3261 T3261 ROOT contributes,contributes
R2305 T3262 T3261 advmod significantly,contributes
R2306 T3122 T3124 nsubj integrin,regulates
R2307 T3263 T3261 prep to,contributes
R2308 T3264 T3265 compound TMZ,cytotoxicity
R2309 T3265 T3263 pobj cytotoxicity,to
R2310 T3266 T3271 advmod particularly,repaired
R2311 T3267 T3271 advmod when,repaired
R2312 T3268 T3269 amod O6-methylguanine,adducts
R2313 T3123 T3124 advmod negatively,regulates
R2314 T3269 T3271 nsubjpass adducts,repaired
R2315 T3270 T3271 auxpass are,repaired
R2316 T3271 T3261 advcl repaired,contributes
R2317 T3124 T3124 ROOT regulates,regulates
R2318 T3272 T3271 cc or,repaired
R2319 T3273 T3271 conj tolerated,repaired
R2320 T3274 T3283 punct (,al.
R2321 T3275 T3277 nmod Goellner,al.
R2322 T3125 T3124 dobj p53,regulates
R2323 T3276 T3277 nmod et,al.
R2324 T3277 T3283 ccomp al.,al.
R2325 T3126 T3125 acl signaling,p53
R2326 T3278 T3277 punct ",",al.
R2327 T3279 T3277 npadvmod 2011,al.
R2328 T3280 T3283 punct ;,al.
R2329 T3127 T3124 punct ",",regulates
R2330 T3281 T3283 compound Zhang,al.
R2331 T3282 T3283 nmod et,al.
R2332 T3283 T3283 ROOT al.,al.
R2333 T3128 T3124 cc and,regulates
R2334 T3284 T3285 punct ",",2012b
R2335 T3285 T3283 amod 2012b,al.
R2336 T3286 T3285 punct ),2012b
R2337 T3129 T3130 det the,event
R2338 T3287 T3261 punct .,contributes
R2339 T3130 T3131 nsubj event,induces
R2340 T3288 T3289 amod Dual,targeting
R2341 T3131 T3124 conj induces,regulates
R2342 T3132 T3134 amod glioma,resistance
R2343 T3289 T3301 nsubj targeting,reverse
R2344 T3290 T3289 prep of,targeting
R2345 T3291 T3293 compound base,repair
R2346 T3133 T3134 compound cell,resistance
R2347 T3292 T3293 compound excision,repair
R2348 T3293 T3290 pobj repair,of
R2349 T3134 T3131 dobj resistance,induces
R2350 T3294 T3293 cc and,repair
R2351 T3295 T3299 nmod NAD,biosynthesis
R2352 T3296 T3297 punct (,+
R2353 T3135 T3134 prep to,resistance
R2354 T3297 T3295 parataxis +,NAD
R2355 T3298 T3299 punct ),biosynthesis
R2356 T3299 T3293 conj biosynthesis,repair
R2357 T3300 T3301 aux may,reverse
R2358 T3136 T3135 pobj TMZ,to
R2359 T3301 T3301 ROOT reverse,reverse
R2360 T3302 T3303 compound TMZ,resistance
R2361 T3303 T3301 dobj resistance,reverse
R2362 T3304 T3301 prep in,reverse
R2363 T3305 T3304 pobj patients,in
R2364 T3306 T3305 prep with,patients
R2365 T3137 T3140 punct (,al.
R2366 T3307 T3310 amod resistant,GBM
R2367 T3308 T3307 cc and,resistant
R2368 T3309 T3307 conj recurrent,resistant
R2369 T3138 T3140 nmod Janouskova,al.
R2370 T3310 T3306 pobj GBM,with
R2371 T3311 T3310 punct (,GBM
R2372 T3312 T3314 nmod Goellner,al.
R2373 T3139 T3140 nmod et,al.
R2374 T3313 T3314 nmod et,al.
R2375 T3314 T3301 dep al.,reverse
R2376 T3140 T3134 appos al.,resistance
R2377 T3141 T3140 punct ",",al.
R2378 T3315 T3314 punct ",",al.
R2379 T3142 T3140 npadvmod 2012,al.
R2380 T3316 T3314 npadvmod 2011,al.
R2381 T3317 T3314 punct ),al.
R2382 T3318 T3301 punct .,reverse
R2383 T3319 T3337 nsubj Interferon-β,increase
R2384 T3143 T3131 punct ),induces
R2385 T3320 T3321 punct (,IFN-β
R2386 T3321 T3319 appos IFN-β,Interferon-β
R2387 T3322 T3321 punct ),IFN-β
R2388 T3144 T3124 punct .,regulates
R2389 T3323 T3319 punct ",",Interferon-β
R2390 T3324 T3319 appos levetiracetam,Interferon-β
R2391 T3325 T3326 punct (,LEV
R2392 T3145 T3146 amod α5β1,integrin
R2393 T3326 T3324 appos LEV,levetiracetam
R2394 T3327 T3326 punct ),LEV
R2395 T3328 T3324 punct ",",levetiracetam
R2396 T3146 T3148 nsubjpass integrin,considered
R2397 T3329 T3324 conj resveratrol,levetiracetam
R2398 T3330 T3329 punct ",",resveratrol
R2399 T3331 T3329 cc and,resveratrol
R2400 T3147 T3148 auxpass is,considered
R2401 T3332 T3333 amod valproic,acid
R2402 T3333 T3329 conj acid,resveratrol
R2403 T3334 T3333 punct (,acid
R2404 T3335 T3337 nsubj VAP,increase
R2405 T3148 T3148 ROOT considered,considered
R2406 T3336 T3337 punct ),increase
R2407 T3337 T3337 ROOT increase,increase
R2408 T3149 T3148 prep as,considered
R2409 T3338 T3339 det the,sensitivity
R2410 T3339 T3337 dobj sensitivity,increase
R2411 T3340 T3339 prep of,sensitivity
R2412 T3341 T3340 pobj TMZ,of
R2413 T3342 T3337 prep through,increase
R2414 T3150 T3152 det a,target
R2415 T3343 T3342 pobj MGMT-dependent,through
R2416 T3344 T3343 cc or,MGMT-dependent
R2417 T3345 T3346 punct -,independent
R2418 T3151 T3152 amod therapeutic,target
R2419 T3443 T3442 prep in,failure
R2420 T3346 T3347 amod independent,mechanisms
R2421 T3347 T3343 conj mechanisms,MGMT-dependent
R2422 T3348 T3347 punct (,mechanisms
R2423 T3444 T3445 compound TMZ,treatment
R2424 T3349 T3351 compound Nakada,al.
R2425 T3350 T3351 nmod et,al.
R2426 T3351 T3347 appos al.,mechanisms
R2427 T3445 T3443 pobj treatment,in
R2428 T3352 T3351 punct ",",al.
R2429 T3353 T3351 npadvmod 2012,al.
R2430 T3446 T3437 punct .,are
R2431 T3354 T3347 punct ),mechanisms
R2432 T3447 T3448 det The,concept
R2433 T3355 T3337 punct .,increase
R2434 T3356 T3362 nsubj Resveratrol,reverses
R2435 T3357 T3356 punct ",",Resveratrol
R2436 T3448 T3478 nsubjpass concept,al.
R2437 T3358 T3360 det a,polyphenol
R2438 T3359 T3360 amod natural,polyphenol
R2439 T3360 T3356 appos polyphenol,Resveratrol
R2440 T3361 T3356 punct ",",Resveratrol
R2441 T3449 T3448 prep of,concept
R2442 T3362 T3362 ROOT reverses,reverses
R2443 T3363 T3364 compound TMZ,resistance
R2444 T3450 T3452 compound cancer,cell
R2445 T3364 T3362 dobj resistance,reverses
R2446 T3365 T3362 prep via,reverses
R2447 T3366 T3368 det an,mechanism
R2448 T3451 T3452 compound stem,cell
R2449 T3367 T3368 amod NF-κB-dependent,mechanism
R2450 T3368 T3365 pobj mechanism,via
R2451 T3369 T3368 punct (,mechanism
R2452 T3452 T3453 compound cell,survival
R2453 T3370 T3372 compound Huang,al.
R2454 T3371 T3372 nmod et,al.
R2455 T3453 T3449 pobj survival,of
R2456 T3372 T3368 appos al.,mechanism
R2457 T3373 T3372 punct ",",al.
R2458 T3374 T3372 npadvmod 2012,al.
R2459 T3454 T3448 prep from,concept
R2460 T3375 T3368 punct ),mechanism
R2461 T3376 T3362 punct .,reverses
R2462 T3377 T3378 nummod STAT3,inhibitor
R2463 T3378 T3384 nmod inhibitor,efficacy
R2464 T3379 T3378 cc or,inhibitor
R2465 T3380 T3382 nummod STAT3,potentiates
R2466 T3381 T3382 amod knockdown,potentiates
R2467 T3455 T3454 pobj treatment,from
R2468 T3382 T3378 conj potentiates,inhibitor
R2469 T3383 T3384 compound TMZ,efficacy
R2470 T3384 T3384 ROOT efficacy,efficacy
R2471 T3456 T3448 prep with,concept
R2472 T3385 T3384 prep in,efficacy
R2473 T3386 T3389 amod resistant,lines
R2474 T3457 T3456 pobj TMZ,with
R2475 T3387 T3389 nmod GBM,lines
R2476 T3388 T3389 compound cell,lines
R2477 T3389 T3385 pobj lines,in
R2478 T3458 T3457 cc and,TMZ
R2479 T3390 T3389 punct (,lines
R2480 T3391 T3393 compound Kohsaka,al.
R2481 T3392 T3393 nmod et,al.
R2482 T3459 T3461 amod other,drugs
R2483 T3393 T3389 appos al.,lines
R2484 T3460 T3461 amod chemotherapeutic,drugs
R2485 T3394 T3393 punct ",",al.
R2486 T3461 T3457 conj drugs,TMZ
R2487 T3395 T3393 npadvmod 2012,al.
R2488 T3396 T3389 punct ),lines
R2489 T3462 T3463 aux has,been
R2490 T3397 T3384 punct .,efficacy
R2491 T3398 T3399 compound Intratumoral,hypoxia
R2492 T3399 T3400 nsubj hypoxia,is
R2493 T3463 T3478 auxpass been,al.
R2494 T3400 T3400 ROOT is,is
R2495 T3401 T3400 acomp common,is
R2496 T3464 T3465 advmod more,complicated
R2497 T3402 T3400 prep in,is
R2498 T3403 T3402 pobj GBMs,in
R2499 T3465 T3478 ccomp complicated,al.
R2500 T3404 T3400 cc and,is
R2501 T3405 T3407 aux may,associated
R2502 T3406 T3407 auxpass be,associated
R2503 T3466 T3468 mark than,thought
R2504 T3407 T3400 conj associated,is
R2505 T3408 T3407 prep with,associated
R2506 T3409 T3410 det the,development
R2507 T3467 T3468 advmod previously,thought
R2508 T3410 T3408 pobj development,with
R2509 T3411 T3410 prep of,development
R2510 T3412 T3413 compound TMZ,resistance
R2511 T3413 T3411 pobj resistance,of
R2512 T3414 T3400 punct .,is
R2513 T3415 T3416 amod Induced,hyperoxia
R2514 T3468 T3465 advcl thought,complicated
R2515 T3416 T3419 nsubjpass hyperoxia,utilized
R2516 T3417 T3419 aux can,utilized
R2517 T3418 T3419 auxpass be,utilized
R2518 T3419 T3419 ROOT utilized,utilized
R2519 T3469 T3465 punct (,complicated
R2520 T3420 T3421 aux to,reverse
R2521 T3421 T3419 xcomp reverse,utilized
R2522 T3422 T3423 compound TMZ,resistance
R2523 T3470 T3472 nmod Beier,al.
R2524 T3423 T3421 dobj resistance,reverse
R2525 T3424 T3421 prep in,reverse
R2526 T3425 T3424 pobj GBMs,in
R2527 T3471 T3472 nmod et,al.
R2528 T3472 T3465 punct al.,complicated
R2529 T3426 T3429 punct (,al.
R2530 T3473 T3472 punct ",",al.
R2531 T3427 T3429 nmod Sun,al.
R2532 T3428 T3429 nmod et,al.
R2533 T3429 T3419 parataxis al.,utilized
R2534 T3474 T3472 npadvmod 2011,al.
R2535 T3430 T3429 punct ",",al.
R2536 T3431 T3429 npadvmod 2012,al.
R2537 T3475 T3478 punct ;,al.
R2538 T3432 T3429 punct ),al.
R2539 T3433 T3419 punct .,utilized
R2540 T3434 T3436 compound Cancer,cells
R2541 T3476 T3478 compound Chen,al.
R2542 T3435 T3436 compound stem,cells
R2543 T3436 T3437 nsubj cells,are
R2544 T3437 T3437 ROOT are,are
R2545 T3477 T3478 compound et,al.
R2546 T3478 T3478 ROOT al.,al.
R2547 T3479 T3478 punct ",",al.
R2548 T3438 T3437 advmod probably,are
R2549 T3439 T3440 det the,key
R2550 T3480 T3478 npadvmod 2012,al.
R2551 T3440 T3437 attr key,are
R2552 T3441 T3440 prep to,key
R2553 T3481 T3478 punct ),al.
R2554 T3442 T3441 pobj failure,to
R2555 T3482 T3478 punct .,al.
R2556 T3483 T3486 amod CD133-positive,cells
R2557 T3484 T3485 compound cancer,stem
R2558 T3485 T3486 compound stem,cells
R2559 T3488 T3488 ROOT expressed,expressed
R2560 T3489 T3488 prep in,expressed
R2561 T3490 T3493 det both,cells
R2562 T3491 T3493 amod normal,cells
R2563 T3486 T3488 nsubjpass cells,expressed
R2564 T3492 T3493 compound stem,cells
R2565 T3493 T3489 pobj cells,in
R2566 T3494 T3493 cc and,cells
R2567 T3495 T3496 compound cancer,stem
R2568 T3487 T3488 auxpass are,expressed
R2569 T3496 T3497 compound stem,cells
R2570 T3497 T3493 conj cells,cells
R2571 T3498 T3488 punct (,expressed
R2572 T3499 T3488 dep Donovan,expressed
R2573 T3500 T3499 cc and,Donovan
R2574 T3501 T3499 conj Pilkington,Donovan
R2575 T3502 T3501 punct ",",Pilkington
R2576 T3503 T3501 npadvmod 2012,Pilkington
R2577 T3504 T3501 punct ),Pilkington
R2578 T3505 T3488 punct .,expressed
R2579 T3506 T3529 advmod However,established
R2580 T3507 T3529 punct ",",established
R2581 T3508 T3509 det the,role
R2582 T3509 T3529 nsubjpass role,established
R2583 T3510 T3509 prep of,role
R2584 T3511 T3510 pobj CD133,of
R2585 T3512 T3509 prep as,role
R2586 T3513 T3514 det a,marker
R2587 T3514 T3512 pobj marker,as
R2588 T3515 T3514 prep for,marker
R2589 T3516 T3519 amod glioma,cells
R2590 T3517 T3518 compound cancer,stem
R2591 T3518 T3519 compound stem,cells
R2592 T3519 T3515 pobj cells,for
R2593 T3520 T3519 amod relative,cells
R2594 T3521 T3520 prep to,relative
R2595 T3522 T3524 poss its,function
R2596 T3523 T3524 amod biological,function
R2597 T3524 T3521 pobj function,to
R2598 T3525 T3529 aux has,established
R2599 T3526 T3529 advmod yet,established
R2600 T3527 T3529 aux to,established
R2601 T3528 T3529 auxpass be,established
R2602 T3529 T3529 ROOT established,established
R2603 T3530 T3529 punct .,established