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PMC:3586680 / 1079-23150 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2503 58-70 NNP denotes Glioblastoma
T2504 71-81 JJ denotes multiforme
T2505 82-90 VBZ denotes afflicts
T2506 91-97 CD denotes 12,500
T2507 98-101 JJ denotes new
T2508 102-110 NNS denotes patients
T2509 111-113 IN denotes in
T2510 114-117 DT denotes the
T2511 118-122 NNP denotes U.S.
T2512 123-131 RB denotes annually
T2513 132-133 -LRB- denotes (
T2514 133-141 NNP denotes Friedman
T2515 142-144 FW denotes et
T2516 145-148 FW denotes al.
T2517 148-149 , denotes ,
T2518 150-154 CD denotes 2000
T2519 154-155 : denotes ;
T2520 156-161 NNP denotes Stupp
T2521 162-164 FW denotes et
T2522 165-168 FW denotes al.
T2523 168-169 , denotes ,
T2524 170-174 CD denotes 2009
T2525 174-175 : denotes ;
T2526 176-182 NNP denotes Silber
T2527 183-185 FW denotes et
T2528 186-189 FW denotes al.
T2529 189-190 , denotes ,
T2530 191-195 CD denotes 2012
T2531 195-196 -RRB- denotes )
T2532 196-197 . denotes .
T2533 198-210 NNP denotes Glioblastoma
T2534 211-212 -LRB- denotes (
T2535 212-215 NNP denotes GBM
T2536 215-216 -RRB- denotes )
T2537 217-219 VBZ denotes is
T2538 220-226 RB denotes highly
T2539 227-233 JJ denotes lethal
T2540 233-234 , denotes ,
T2541 235-238 CC denotes and
T2542 239-242 DT denotes the
T2543 243-250 JJ denotes average
T2544 251-259 NN denotes survival
T2545 260-270 NN denotes expectancy
T2546 271-273 VBZ denotes is
T2547 274-278 CD denotes 14.6
T2548 279-285 NNS denotes months
T2549 285-286 , denotes ,
T2550 287-290 CC denotes and
T2551 291-294 DT denotes the
T2552 295-302 JJ denotes overall
T2553 303-309 JJ denotes 5-year
T2554 310-318 NN denotes survival
T2555 319-323 NN denotes rate
T2556 324-327 IN denotes for
T2557 328-331 NNP denotes GBM
T2558 332-334 VBZ denotes is
T2559 335-339 RB denotes only
T2560 340-343 CD denotes 9.8
T2561 343-344 NN denotes %
T2562 345-346 -LRB- denotes (
T2563 346-354 NNP denotes Friedman
T2564 355-357 FW denotes et
T2565 358-361 FW denotes al.
T2566 361-362 , denotes ,
T2567 363-367 CD denotes 2000
T2568 367-368 : denotes ;
T2569 369-374 NNP denotes Stupp
T2570 375-377 FW denotes et
T2571 378-381 FW denotes al.
T2572 381-382 , denotes ,
T2573 383-387 CD denotes 2009
T2574 387-388 -RRB- denotes )
T2575 388-389 . denotes .
T2576 390-394 JJ denotes High
T2577 395-401 NNS denotes levels
T2578 402-404 IN denotes of
T2579 405-415 NN denotes resistance
T2580 416-418 TO denotes to
T2581 419-426 JJ denotes current
T2582 427-438 JJ denotes therapeutic
T2583 439-449 NNS denotes modalities
T2584 450-453 CC denotes and
T2585 454-460 NN denotes cancer
T2586 461-468 NN denotes relapse
T2587 469-472 VBP denotes are
T2588 473-483 RB denotes frequently
T2589 484-488 VBN denotes seen
T2590 489-491 IN denotes in
T2591 492-500 NNS denotes patients
T2592 501-502 -LRB- denotes (
T2593 502-506 NNP denotes Haar
T2594 507-509 FW denotes et
T2595 510-513 FW denotes al.
T2596 513-514 , denotes ,
T2597 515-519 CD denotes 2012
T2598 519-520 : denotes ;
T2599 521-528 NNP denotes Happold
T2600 529-531 FW denotes et
T2601 532-535 FW denotes al.
T2602 535-536 , denotes ,
T2603 537-541 CD denotes 2012
T2604 541-542 -RRB- denotes )
T2605 542-543 . denotes .
T2606 544-547 DT denotes The
T2607 548-555 JJ denotes current
T2608 556-564 JJ denotes standard
T2609 565-572 NN denotes therapy
T2610 573-576 IN denotes for
T2611 577-580 NNP denotes GBM
T2612 581-587 RB denotes mainly
T2613 588-596 VBZ denotes includes
T2614 597-604 NN denotes maximum
T2615 605-614 NN denotes debulking
T2616 615-622 NN denotes surgery
T2617 622-623 , denotes ,
T2618 624-633 NN denotes radiation
T2619 633-634 , denotes ,
T2620 635-638 CC denotes and
T2621 639-648 NN denotes treatment
T2622 649-653 IN denotes with
T2623 654-657 DT denotes the
T2624 658-672 JJ denotes monofunctional
T2625 673-683 NN denotes alkylating
T2626 684-689 NN denotes agent
T2627 690-702 NN denotes temozolomide
T2628 703-704 -LRB- denotes (
T2629 704-707 NNP denotes TMZ
T2630 707-708 -RRB- denotes )
T2631 709-710 -LRB- denotes (
T2632 710-718 NNP denotes Friedman
T2633 719-721 FW denotes et
T2634 722-725 FW denotes al.
T2635 725-726 , denotes ,
T2636 727-731 CD denotes 2000
T2637 731-732 : denotes ;
T2638 733-742 NNP denotes Nishikawa
T2639 742-743 , denotes ,
T2640 744-748 CD denotes 2010
T2641 748-749 -RRB- denotes )
T2642 749-750 . denotes .
T2643 751-759 JJ denotes Multiple
T2644 760-770 NNS denotes mechanisms
T2645 771-774 VBP denotes are
T2646 775-783 VBN denotes involved
T2647 784-786 IN denotes in
T2648 787-790 DT denotes the
T2649 791-794 NNP denotes TMZ
T2650 795-805 NN denotes resistance
T2651 805-806 , denotes ,
T2652 807-812 WDT denotes which
T2653 813-816 MD denotes may
T2654 817-824 VB denotes include
T2655 825-831 NN denotes cancer
T2656 832-836 NN denotes stem
T2657 837-842 NNS denotes cells
T2658 842-843 , denotes ,
T2659 844-853 NNS denotes microRNAs
T2660 853-854 , denotes ,
T2661 855-859 NN denotes drug
T2662 860-866 NN denotes efflux
T2663 866-867 , denotes ,
T2664 868-871 NNP denotes DNA
T2665 872-878 NN denotes damage
T2666 879-885 NN denotes repair
T2667 885-886 , denotes ,
T2668 887-892 NN denotes tumor
T2669 893-898 NNS denotes cells
T2670 899-904 IN denotes under
T2671 905-912 NN denotes hypoxia
T2672 912-913 , denotes ,
T2673 914-921 NN denotes histone
T2674 922-935 NN denotes deacetylation
T2675 935-936 , denotes ,
T2676 937-959 JJ denotes epithelial-mesenchymal
T2677 960-970 NN denotes transition
T2678 970-971 , denotes ,
T2679 972-977 CD denotes STAT3
T2680 978-984 NN denotes kinase
T2681 984-985 , denotes ,
T2682 986-989 CC denotes and
T2683 990-994 JJ denotes many
T2684 995-1001 NNS denotes others
T2685 1002-1003 -LRB- denotes (
T2686 1003-1007 NNP denotes Haar
T2687 1008-1010 FW denotes et
T2688 1011-1014 FW denotes al.
T2689 1014-1015 , denotes ,
T2690 1016-1020 CD denotes 2012
T2691 1020-1021 : denotes ;
T2692 1022-1029 NNP denotes Happold
T2693 1030-1032 FW denotes et
T2694 1033-1036 FW denotes al.
T2695 1036-1037 , denotes ,
T2696 1038-1042 CD denotes 2012
T2697 1042-1043 : denotes ;
T2698 1044-1055 NNP denotes Johannessen
T2699 1056-1059 CC denotes and
T2700 1060-1068 NNP denotes Bjerkvig
T2701 1068-1069 , denotes ,
T2702 1070-1074 CD denotes 2012
T2703 1074-1075 : denotes ;
T2704 1076-1083 NNP denotes Kitange
T2705 1084-1086 FW denotes et
T2706 1087-1090 FW denotes al.
T2707 1090-1091 , denotes ,
T2708 1092-1096 CD denotes 2012
T2709 1096-1097 : denotes ;
T2710 1098-1105 NNP denotes Kohsaka
T2711 1106-1108 FW denotes et
T2712 1109-1112 FW denotes al.
T2713 1112-1113 , denotes ,
T2714 1114-1118 CD denotes 2012
T2715 1118-1119 : denotes ;
T2716 1120-1125 NNP denotes Zhang
T2717 1126-1128 FW denotes et
T2718 1129-1132 FW denotes al.
T2719 1132-1133 , denotes ,
T2720 1134-1139 JJ denotes 2012b
T2721 1139-1140 -RRB- denotes )
T2722 1140-1141 . denotes .
T2723 1142-1154 NNP denotes Temozolomide
T2724 1155-1162 VBZ denotes induces
T2725 1163-1173 NN denotes generation
T2726 1174-1176 IN denotes of
T2727 1177-1180 NNP denotes DNA
T2728 1181-1188 NNS denotes lesions
T2729 1188-1189 , denotes ,
T2730 1190-1199 VBG denotes including
T2731 1200-1216 NNP denotes O6-methylguanine
T2732 1216-1217 , denotes ,
T2733 1218-1234 NNP denotes N3-methyladenine
T2734 1234-1235 , denotes ,
T2735 1236-1239 CC denotes and
T2736 1240-1256 NNP denotes N7-methylguanine
T2737 1257-1258 -LRB- denotes (
T2738 1258-1266 NNP denotes Goellner
T2739 1267-1269 FW denotes et
T2740 1270-1273 FW denotes al.
T2741 1273-1274 , denotes ,
T2742 1275-1279 CD denotes 2011
T2743 1279-1280 : denotes ;
T2744 1281-1286 NNP denotes Zhang
T2745 1287-1289 FW denotes et
T2746 1290-1293 FW denotes al.
T2747 1293-1294 , denotes ,
T2748 1295-1300 JJ denotes 2012b
T2749 1300-1301 -RRB- denotes )
T2750 1301-1302 . denotes .
T2751 1303-1306 DT denotes The
T2752 1307-1323 JJ denotes O6-methylguanine
T2753 1324-1330 NN denotes lesion
T2754 1331-1333 VBZ denotes is
T2755 1334-1339 VBN denotes known
T2756 1340-1342 TO denotes to
T2757 1343-1350 VB denotes trigger
T2758 1351-1360 NN denotes autophagy
T2759 1360-1361 , denotes ,
T2760 1362-1368 RB denotes rather
T2761 1369-1373 IN denotes than
T2762 1374-1383 NN denotes apoptosis
T2763 1383-1384 , denotes ,
T2764 1385-1387 TO denotes to
T2765 1388-1393 VB denotes cause
T2766 1394-1398 NN denotes cell
T2767 1399-1404 NN denotes death
T2768 1405-1406 -LRB- denotes (
T2769 1406-1413 NNP denotes Kanzawa
T2770 1414-1416 FW denotes et
T2771 1417-1420 FW denotes al.
T2772 1420-1421 , denotes ,
T2773 1422-1426 CD denotes 2003
T2774 1426-1427 -RRB- denotes )
T2775 1427-1428 . denotes .
T2776 1429-1433 RB denotes Also
T2777 1433-1434 , denotes ,
T2778 1435-1445 NN denotes inhibition
T2779 1446-1448 IN denotes of
T2780 1449-1462 JJ denotes antiapoptotic
T2781 1463-1468 NN denotes Bcl-2
T2782 1469-1471 IN denotes by
T2783 1472-1473 DT denotes a
T2784 1474-1483 NN denotes pan-Bcl-2
T2785 1484-1493 NN denotes inhibitor
T2786 1494-1495 -LRB- denotes (
T2787 1495-1496 FW denotes −
T2788 1496-1497 -RRB- denotes )
T2789 1497-1498 : denotes -
T2790 1498-1506 NN denotes gossypol
T2791 1507-1512 VBZ denotes leads
T2792 1513-1515 TO denotes to
T2793 1516-1526 JJ denotes autophagic
T2794 1527-1532 NN denotes death
T2795 1533-1535 IN denotes in
T2796 1536-1543 NNS denotes gliomas
T2797 1544-1547 CC denotes and
T2798 1548-1556 VBZ denotes enhances
T2799 1557-1560 DT denotes the
T2800 1561-1567 NN denotes action
T2801 1568-1570 IN denotes of
T2802 1571-1574 NNP denotes TMZ
T2803 1575-1576 -LRB- denotes (
T2804 1576-1580 NNP denotes Voss
T2805 1581-1583 FW denotes et
T2806 1584-1587 FW denotes al.
T2807 1587-1588 , denotes ,
T2808 1589-1593 CD denotes 2010
T2809 1593-1594 -RRB- denotes )
T2810 1594-1595 . denotes .
T2811 1596-1603 RB denotes However
T2812 1603-1604 , denotes ,
T2813 1605-1606 DT denotes a
T2814 1607-1613 JJ denotes recent
T2815 1614-1619 NN denotes study
T2816 1620-1632 VBD denotes demonstrated
T2817 1633-1637 IN denotes that
T2818 1638-1649 JJ denotes TMZ-induced
T2819 1650-1659 NN denotes autophagy
T2820 1660-1662 VBZ denotes is
T2821 1663-1675 JJ denotes pro-survival
T2822 1675-1676 , denotes ,
T2823 1677-1680 CC denotes and
T2824 1681-1684 MD denotes may
T2825 1685-1690 VB denotes block
T2826 1691-1694 DT denotes the
T2827 1695-1703 JJ denotes eventual
T2828 1704-1713 NN denotes apoptosis
T2829 1714-1716 IN denotes in
T2830 1717-1720 NNP denotes GBM
T2831 1721-1726 NNS denotes cells
T2832 1727-1728 -LRB- denotes (
T2833 1728-1736 NNP denotes Knizhnik
T2834 1737-1739 FW denotes et
T2835 1740-1743 FW denotes al.
T2836 1743-1744 , denotes ,
T2837 1745-1749 CD denotes 2013
T2838 1749-1750 -RRB- denotes )
T2839 1750-1751 . denotes .
T2840 1752-1756 RB denotes Also
T2841 1756-1757 , denotes ,
T2842 1758-1763 NNP denotes MAPO2
T2843 1764-1765 -LRB- denotes (
T2844 1765-1773 NNP denotes C1orf201
T2845 1773-1774 -RRB- denotes )
T2846 1775-1779 NN denotes gene
T2847 1780-1792 VBZ denotes participates
T2848 1793-1795 IN denotes in
T2849 1796-1799 DT denotes the
T2850 1800-1816 JJ denotes O6-methylguanine
T2851 1817-1831 JJ denotes lesion-induced
T2852 1832-1841 NN denotes apoptosis
T2853 1842-1843 -LRB- denotes (
T2854 1843-1851 NNP denotes Fujikane
T2855 1852-1854 FW denotes et
T2856 1855-1858 FW denotes al.
T2857 1858-1859 , denotes ,
T2858 1860-1864 CD denotes 2012
T2859 1864-1865 -RRB- denotes )
T2860 1865-1866 . denotes .
T2861 1867-1872 CD denotes MAPO2
T2862 1873-1877 NN denotes gene
T2863 1878-1885 VBZ denotes encodes
T2864 1886-1887 DT denotes a
T2865 1888-1893 NN denotes novel
T2866 1894-1900 NN denotes 37-kDa
T2867 1901-1908 NN denotes protein
T2868 1908-1909 . denotes .
T2869 1910-1912 PRP denotes It
T2870 1913-1915 VBZ denotes is
T2871 1916-1919 RB denotes not
T2872 1920-1930 VBN denotes determined
T2873 1931-1938 IN denotes whether
T2874 1939-1943 DT denotes this
T2875 1944-1948 NN denotes gene
T2876 1949-1951 VBZ denotes is
T2877 1952-1960 VBN denotes involved
T2878 1961-1963 IN denotes in
T2879 1964-1973 NN denotes autophagy
T2880 1973-1974 . denotes .
T2881 1975-1978 DT denotes The
T2882 1979-1995 JJ denotes O6-methylguanine
T2883 1996-2002 NN denotes lesion
T2884 2003-2005 VBZ denotes is
T2885 2006-2007 DT denotes a
T2886 2008-2017 NN denotes substrate
T2887 2018-2021 IN denotes for
T2888 2022-2028 JJ denotes direct
T2889 2029-2035 NN denotes repair
T2890 2036-2038 IN denotes by
T2891 2039-2059 NNP denotes O6-methylguanine-DNA
T2892 2060-2077 NN denotes methyltransferase
T2893 2078-2079 -LRB- denotes (
T2894 2079-2083 NNP denotes MGMT
T2895 2083-2084 -RRB- denotes )
T2896 2085-2086 -LRB- denotes (
T2897 2086-2093 NNP denotes Pollack
T2898 2094-2096 FW denotes et
T2899 2097-2100 FW denotes al.
T2900 2100-2101 , denotes ,
T2901 2102-2106 CD denotes 2006
T2902 2106-2107 : denotes ;
T2903 2108-2112 NNP denotes Hegi
T2904 2113-2115 FW denotes et
T2905 2116-2119 FW denotes al.
T2906 2119-2120 , denotes ,
T2907 2121-2125 CD denotes 2008
T2908 2125-2126 : denotes ;
T2909 2127-2136 NNP denotes Fukushima
T2910 2137-2139 FW denotes et
T2911 2140-2143 FW denotes al.
T2912 2143-2144 , denotes ,
T2913 2145-2149 CD denotes 2009
T2914 2149-2150 : denotes ;
T2915 2151-2156 NNP denotes Zhang
T2916 2157-2159 FW denotes et
T2917 2160-2163 FW denotes al.
T2918 2163-2164 , denotes ,
T2919 2165-2170 JJ denotes 2012b
T2920 2170-2171 -RRB- denotes )
T2921 2171-2172 . denotes .
T2922 2173-2180 IN denotes Without
T2923 2181-2185 NNP denotes MGMT
T2924 2186-2192 NN denotes repair
T2925 2192-2193 , denotes ,
T2926 2194-2210 JJ denotes O6-methylguanine
T2927 2211-2220 NNS denotes initiates
T2928 2221-2231 NN denotes activation
T2929 2232-2234 IN denotes of
T2930 2235-2243 NN denotes mismatch
T2931 2244-2260 NN denotes repair-deficient
T2932 2261-2262 -LRB- denotes (
T2933 2262-2265 NNP denotes MMR
T2934 2265-2266 -RRB- denotes )
T2935 2267-2275 NNS denotes proteins
T2936 2276-2278 CC denotes or
T2937 2279-2291 JJ denotes Rad3-related
T2938 2292-2299 NN denotes protein
T2939 2300-2306 NN denotes kinase
T2940 2307-2311 WDT denotes that
T2941 2312-2322 RB denotes ultimately
T2942 2323-2328 VBZ denotes leads
T2943 2329-2331 TO denotes to
T2944 2332-2341 JJ denotes apoptotic
T2945 2342-2346 NN denotes cell
T2946 2347-2352 NN denotes death
T2947 2353-2354 -LRB- denotes (
T2948 2354-2362 NNP denotes Caporali
T2949 2363-2365 FW denotes et
T2950 2366-2369 FW denotes al.
T2951 2369-2370 , denotes ,
T2952 2371-2375 CD denotes 2004
T2953 2375-2376 : denotes ;
T2954 2377-2381 NNP denotes Wang
T2955 2382-2385 CC denotes and
T2956 2386-2394 NNP denotes Edelmann
T2957 2394-2395 , denotes ,
T2958 2396-2400 CD denotes 2006
T2959 2400-2401 : denotes ;
T2960 2402-2406 NNP denotes Roos
T2961 2407-2409 FW denotes et
T2962 2410-2413 FW denotes al.
T2963 2413-2414 , denotes ,
T2964 2415-2419 CD denotes 2007
T2965 2419-2420 -RRB- denotes )
T2966 2420-2421 . denotes .
T2967 2422-2426 NNP denotes High
T2968 2427-2437 NN denotes expression
T2969 2438-2440 IN denotes of
T2970 2441-2445 NNP denotes MGMT
T2971 2446-2448 CC denotes or
T2972 2449-2453 NN denotes loss
T2973 2454-2456 IN denotes of
T2974 2457-2460 NNP denotes MMR
T2975 2461-2472 VBZ denotes contributes
T2976 2473-2486 RB denotes significantly
T2977 2487-2489 TO denotes to
T2978 2490-2493 NNP denotes TMZ
T2979 2494-2504 NN denotes resistance
T2980 2505-2507 IN denotes in
T2981 2508-2512 JJ denotes many
T2982 2513-2521 JJ denotes clinical
T2983 2522-2527 NNS denotes cases
T2984 2528-2529 -LRB- denotes (
T2985 2529-2536 NNP denotes Pollack
T2986 2537-2539 FW denotes et
T2987 2540-2543 FW denotes al.
T2988 2543-2544 , denotes ,
T2989 2545-2549 CD denotes 2006
T2990 2549-2550 : denotes ;
T2991 2551-2555 NNP denotes Hegi
T2992 2556-2558 FW denotes et
T2993 2559-2562 FW denotes al.
T2994 2562-2563 , denotes ,
T2995 2564-2568 CD denotes 2008
T2996 2568-2569 : denotes ;
T2997 2570-2578 NNP denotes Sarkaria
T2998 2579-2581 FW denotes et
T2999 2582-2585 FW denotes al.
T3000 2585-2586 , denotes ,
T3001 2587-2591 CD denotes 2008
T3002 2591-2592 -RRB- denotes )
T3003 2592-2593 . denotes .
T3004 2594-2597 DT denotes The
T3005 2598-2608 NN denotes initiation
T3006 2609-2611 IN denotes of
T3007 2612-2621 JJ denotes apoptotic
T3008 2622-2631 VBG denotes signaling
T3009 2632-2637 VBZ denotes fails
T3010 2638-2640 IN denotes in
T3011 2641-2644 DT denotes the
T3012 2645-2652 NN denotes absence
T3013 2653-2655 IN denotes of
T3014 2656-2659 DT denotes the
T3015 2660-2663 NNP denotes MMR
T3016 2664-2670 NN denotes system
T3017 2670-2671 . denotes .
T3018 2672-2683 NN denotes Sensitivity
T3019 2684-2686 TO denotes to
T3020 2687-2690 NNP denotes TMZ
T3021 2691-2693 VBZ denotes is
T3022 2694-2707 RB denotes significantly
T3023 2708-2718 VBN denotes associated
T3024 2719-2723 IN denotes with
T3025 2724-2727 DT denotes the
T3026 2728-2739 NN denotes methylation
T3027 2740-2746 NN denotes status
T3028 2747-2749 IN denotes of
T3029 2750-2754 NNP denotes MGMT
T3030 2755-2759 NN denotes gene
T3031 2760-2768 NN denotes promoter
T3032 2769-2771 IN denotes in
T3033 2772-2777 NNS denotes cells
T3034 2778-2787 VBN denotes committed
T3035 2788-2790 TO denotes to
T3036 2791-2806 NN denotes differentiation
T3037 2807-2808 -LRB- denotes (
T3038 2808-2816 NNP denotes Villalva
T3039 2817-2819 FW denotes et
T3040 2820-2823 FW denotes al.
T3041 2823-2824 , denotes ,
T3042 2825-2829 CD denotes 2012
T3043 2829-2830 -RRB- denotes )
T3044 2830-2831 . denotes .
T3045 2832-2834 DT denotes An
T3046 2835-2843 NN denotes increase
T3047 2844-2846 IN denotes in
T3048 2847-2851 NNP denotes MGMT
T3049 2852-2856 NN denotes gene
T3050 2857-2865 NN denotes promoter
T3051 2866-2877 NN denotes methylation
T3052 2877-2878 , denotes ,
T3053 2879-2884 WDT denotes which
T3054 2885-2891 VBZ denotes blocks
T3055 2892-2896 NNP denotes MGMT
T3056 2897-2904 NN denotes protein
T3057 2905-2915 NN denotes expression
T3058 2915-2916 , denotes ,
T3059 2917-2925 VBZ denotes prolongs
T3060 2926-2932 NN denotes cancer
T3061 2933-2940 NN denotes patient
T3062 2941-2949 NN denotes survival
T3063 2949-2950 . denotes .
T3064 2951-2963 RB denotes Intriguingly
T3065 2963-2964 , denotes ,
T3066 2965-2978 VBD denotes overexpressed
T3067 2979-2990 NN denotes microRNA-21
T3068 2991-2998 VBZ denotes reduces
T3069 2999-3006 NNP denotes Bax/Bcl
T3070 3006-3008 CD denotes -2
T3071 3009-3014 NN denotes ratio
T3072 3015-3018 CC denotes and
T3073 3019-3028 JJ denotes caspase-3
T3074 3029-3037 NN denotes activity
T3075 3037-3038 , denotes ,
T3076 3039-3046 RB denotes thereby
T3077 3047-3055 VBG denotes blocking
T3078 3056-3067 JJ denotes TMZ-induced
T3079 3068-3077 NN denotes apoptosis
T3080 3078-3079 -LRB- denotes (
T3081 3079-3082 NNP denotes Shi
T3082 3083-3085 FW denotes et
T3083 3086-3089 FW denotes al.
T3084 3089-3090 , denotes ,
T3085 3091-3095 CD denotes 2010
T3086 3095-3096 -RRB- denotes )
T3087 3096-3097 . denotes .
T3088 3098-3109 NN denotes MicroRNA-21
T3089 3110-3112 VBZ denotes is
T3090 3113-3123 VBN denotes considered
T3091 3124-3126 IN denotes as
T3092 3127-3128 DT denotes a
T3093 3129-3141 JJ denotes pro-survival
T3094 3142-3148 NN denotes factor
T3095 3149-3152 IN denotes for
T3096 3153-3159 NN denotes cancer
T3097 3160-3165 NNS denotes cells
T3098 3166-3167 -LRB- denotes (
T3099 3167-3169 NNP denotes Li
T3100 3170-3172 FW denotes et
T3101 3173-3176 FW denotes al.
T3102 3176-3177 , denotes ,
T3103 3178-3182 CD denotes 2012
T3104 3182-3183 -RRB- denotes )
T3105 3183-3184 . denotes .
T3106 3185-3194 NNS denotes Integrins
T3107 3195-3199 VBP denotes play
T3108 3200-3201 DT denotes a
T3109 3202-3206 NN denotes role
T3110 3207-3209 IN denotes in
T3111 3210-3213 DT denotes the
T3112 3214-3224 NN denotes resistance
T3113 3225-3227 IN denotes of
T3114 3228-3236 JJ denotes advanced
T3115 3237-3244 NNS denotes cancers
T3116 3245-3247 TO denotes to
T3117 3248-3260 JJ denotes radiotherapy
T3118 3261-3264 CC denotes and
T3119 3265-3277 JJ denotes chemotherapy
T3120 3277-3278 . denotes .
T3121 3279-3283 JJ denotes α5β1
T3122 3284-3292 NN denotes integrin
T3123 3293-3303 RB denotes negatively
T3124 3304-3313 VBZ denotes regulates
T3125 3314-3317 NN denotes p53
T3126 3318-3327 VBG denotes signaling
T3127 3327-3328 , denotes ,
T3128 3329-3332 CC denotes and
T3129 3333-3336 DT denotes the
T3130 3337-3342 NN denotes event
T3131 3343-3350 VBZ denotes induces
T3132 3351-3357 NN denotes glioma
T3133 3358-3362 NN denotes cell
T3134 3363-3373 NN denotes resistance
T3135 3374-3376 TO denotes to
T3136 3377-3380 NNP denotes TMZ
T3137 3381-3382 -LRB- denotes (
T3138 3382-3392 NNP denotes Janouskova
T3139 3393-3395 FW denotes et
T3140 3396-3399 FW denotes al.
T3141 3399-3400 , denotes ,
T3142 3401-3405 CD denotes 2012
T3143 3405-3406 -RRB- denotes )
T3144 3406-3407 . denotes .
T3145 3408-3412 JJ denotes α5β1
T3146 3413-3421 NN denotes integrin
T3147 3422-3424 VBZ denotes is
T3148 3425-3435 VBN denotes considered
T3149 3436-3438 IN denotes as
T3150 3439-3440 DT denotes a
T3151 3441-3452 JJ denotes therapeutic
T3152 3453-3459 NN denotes target
T3153 3460-3463 IN denotes for
T3154 3464-3474 JJ denotes high-grade
T3155 3475-3480 NN denotes brain
T3156 3481-3487 NNS denotes tumors
T3157 3487-3488 . denotes .
T3158 3489-3492 DT denotes The
T3159 3493-3497 NN denotes base
T3160 3498-3506 NN denotes excision
T3161 3507-3513 NN denotes repair
T3162 3514-3520 NN denotes enzyme
T3163 3521-3550 JJ denotes alkylpurine-DNA-N-glycosylase
T3164 3551-3552 -LRB- denotes (
T3165 3552-3556 NNP denotes APNG
T3166 3556-3557 -RRB- denotes )
T3167 3557-3558 , denotes ,
T3168 3559-3564 WDT denotes which
T3169 3565-3572 NNS denotes repairs
T3170 3573-3576 DT denotes the
T3171 3577-3586 JJ denotes cytotoxic
T3172 3587-3594 NNS denotes lesions
T3173 3595-3611 JJ denotes N3-methyladenine
T3174 3612-3615 CC denotes and
T3175 3616-3632 JJ denotes N7-methylguanine
T3176 3632-3633 , denotes ,
T3177 3634-3638 RB denotes also
T3178 3639-3651 VBZ denotes participates
T3179 3652-3654 IN denotes in
T3180 3655-3658 DT denotes the
T3181 3659-3662 NNP denotes TMZ
T3182 3663-3673 NN denotes resistance
T3183 3674-3675 -LRB- denotes (
T3184 3675-3684 NNP denotes Agnihotri
T3185 3685-3687 FW denotes et
T3186 3688-3691 FW denotes al.
T3187 3691-3692 , denotes ,
T3188 3693-3697 CD denotes 2012
T3189 3697-3698 -RRB- denotes )
T3190 3698-3699 . denotes .
T3191 3700-3712 NNP denotes Upregulation
T3192 3713-3715 IN denotes of
T3193 3716-3729 JJ denotes mitochondrial
T3194 3730-3741 JJ denotes respiratory
T3195 3742-3747 NN denotes chain
T3196 3748-3756 NN denotes coupling
T3197 3757-3759 TO denotes to
T3198 3760-3768 VB denotes suppress
T3199 3769-3772 DT denotes the
T3200 3773-3783 NN denotes production
T3201 3784-3786 IN denotes of
T3202 3787-3795 JJ denotes reactive
T3203 3796-3802 NN denotes oxygen
T3204 3803-3810 NNS denotes species
T3205 3811-3812 -LRB- denotes (
T3206 3812-3815 NNP denotes ROS
T3207 3815-3816 -RRB- denotes )
T3208 3817-3826 VBN denotes regulated
T3209 3827-3829 IN denotes by
T3210 3830-3840 NN denotes cytochrome
T3211 3841-3842 NN denotes c
T3212 3843-3850 NN denotes oxidase
T3213 3851-3862 VBZ denotes contributes
T3214 3863-3865 IN denotes in
T3215 3866-3870 NN denotes part
T3216 3871-3873 TO denotes to
T3217 3874-3877 NNP denotes TMZ
T3218 3878-3888 NN denotes resistance
T3219 3889-3891 IN denotes in
T3220 3892-3899 NNS denotes gliomas
T3221 3900-3901 -LRB- denotes (
T3222 3901-3906 NNP denotes Oliva
T3223 3907-3909 FW denotes et
T3224 3910-3913 FW denotes al.
T3225 3913-3914 , denotes ,
T3226 3915-3919 CD denotes 2011
T3227 3919-3920 -RRB- denotes )
T3228 3920-3921 . denotes .
T3229 3922-3930 NN denotes Reversal
T3230 3931-3933 IN denotes of
T3231 3934-3937 NNP denotes TMZ
T3232 3938-3948 NN denotes resistance
T3233 3949-3952 MD denotes may
T3234 3953-3955 VB denotes be
T3235 3956-3964 VBN denotes achieved
T3236 3965-3967 IN denotes by
T3237 3968-3972 NNP denotes MGMT
T3238 3973-3989 NNS denotes pseudosubstrates
T3239 3989-3990 , denotes ,
T3240 3991-4007 NN denotes O6-benzylguanine
T3241 4008-4011 CC denotes and
T3242 4012-4023 NN denotes lomeguatrib
T3243 4024-4026 TO denotes to
T3244 4027-4036 VB denotes sensitize
T3245 4037-4043 NNS denotes tumors
T3246 4044-4046 TO denotes to
T3247 4047-4050 NNP denotes TMZ
T3248 4051-4052 -LRB- denotes (
T3249 4052-4057 NNP denotes Zhang
T3250 4058-4060 FW denotes et
T3251 4061-4064 FW denotes al.
T3252 4064-4065 , denotes ,
T3253 4066-4071 JJ denotes 2012b
T3254 4071-4072 -RRB- denotes )
T3255 4072-4073 . denotes .
T3256 4074-4094 NN denotes Methoxyamine-blocker
T3257 4095-4097 IN denotes of
T3258 4098-4102 NN denotes base
T3259 4103-4111 NN denotes excision
T3260 4112-4118 NN denotes repair
T3261 4119-4130 VBZ denotes contributes
T3262 4131-4144 RB denotes significantly
T3263 4145-4147 TO denotes to
T3264 4148-4151 NNP denotes TMZ
T3265 4152-4164 NN denotes cytotoxicity
T3266 4165-4177 RB denotes particularly
T3267 4178-4182 WRB denotes when
T3268 4183-4199 JJ denotes O6-methylguanine
T3269 4200-4207 NNS denotes adducts
T3270 4208-4211 VBP denotes are
T3271 4212-4220 VBN denotes repaired
T3272 4221-4223 CC denotes or
T3273 4224-4233 VBN denotes tolerated
T3274 4234-4235 -LRB- denotes (
T3275 4235-4243 NNP denotes Goellner
T3276 4244-4246 FW denotes et
T3277 4247-4250 FW denotes al.
T3278 4250-4251 , denotes ,
T3279 4252-4256 CD denotes 2011
T3280 4256-4257 : denotes ;
T3281 4258-4263 NNP denotes Zhang
T3282 4264-4266 FW denotes et
T3283 4267-4270 FW denotes al.
T3284 4270-4271 , denotes ,
T3285 4272-4277 JJ denotes 2012b
T3286 4277-4278 -RRB- denotes )
T3287 4278-4279 . denotes .
T3288 4280-4284 JJ denotes Dual
T3289 4285-4294 VBG denotes targeting
T3290 4295-4297 IN denotes of
T3291 4298-4302 NN denotes base
T3292 4303-4311 NN denotes excision
T3293 4312-4318 NN denotes repair
T3294 4319-4322 CC denotes and
T3295 4323-4326 NNP denotes NAD
T3296 4326-4327 -LRB- denotes (
T3297 4327-4328 VBN denotes +
T3298 4328-4329 -RRB- denotes )
T3299 4330-4342 NN denotes biosynthesis
T3300 4343-4346 MD denotes may
T3301 4347-4354 VB denotes reverse
T3302 4355-4358 NNP denotes TMZ
T3303 4359-4369 NN denotes resistance
T3304 4370-4372 IN denotes in
T3305 4373-4381 NNS denotes patients
T3306 4382-4386 IN denotes with
T3307 4387-4396 JJ denotes resistant
T3308 4397-4400 CC denotes and
T3309 4401-4410 JJ denotes recurrent
T3310 4411-4414 NNP denotes GBM
T3311 4415-4416 -LRB- denotes (
T3312 4416-4424 NNP denotes Goellner
T3313 4425-4427 FW denotes et
T3314 4428-4431 FW denotes al.
T3315 4431-4432 , denotes ,
T3316 4433-4437 CD denotes 2011
T3317 4437-4438 -RRB- denotes )
T3318 4438-4439 . denotes .
T3319 4440-4452 NNP denotes Interferon-β
T3320 4453-4454 -LRB- denotes (
T3321 4454-4459 NNP denotes IFN-β
T3322 4459-4460 -RRB- denotes )
T3323 4460-4461 , denotes ,
T3324 4462-4475 NN denotes levetiracetam
T3325 4476-4477 -LRB- denotes (
T3326 4477-4480 NNP denotes LEV
T3327 4480-4481 -RRB- denotes )
T3328 4481-4482 , denotes ,
T3329 4483-4494 NN denotes resveratrol
T3330 4494-4495 , denotes ,
T3331 4496-4499 CC denotes and
T3332 4500-4508 JJ denotes valproic
T3333 4509-4513 NN denotes acid
T3334 4514-4515 -LRB- denotes (
T3335 4515-4518 NNP denotes VAP
T3336 4518-4519 -RRB- denotes )
T3337 4520-4528 VB denotes increase
T3338 4529-4532 DT denotes the
T3339 4533-4544 NN denotes sensitivity
T3340 4545-4547 IN denotes of
T3341 4548-4551 NNP denotes TMZ
T3342 4552-4559 IN denotes through
T3343 4560-4574 NNP denotes MGMT-dependent
T3344 4575-4577 CC denotes or
T3345 4578-4579 : denotes -
T3346 4579-4590 JJ denotes independent
T3347 4591-4601 NNS denotes mechanisms
T3348 4602-4603 -LRB- denotes (
T3349 4603-4609 NNP denotes Nakada
T3350 4610-4612 FW denotes et
T3351 4613-4616 FW denotes al.
T3352 4616-4617 , denotes ,
T3353 4618-4622 CD denotes 2012
T3354 4622-4623 -RRB- denotes )
T3355 4623-4624 . denotes .
T3356 4625-4636 NNP denotes Resveratrol
T3357 4636-4637 , denotes ,
T3358 4638-4639 DT denotes a
T3359 4640-4647 JJ denotes natural
T3360 4648-4658 NN denotes polyphenol
T3361 4658-4659 , denotes ,
T3362 4660-4668 VBZ denotes reverses
T3363 4669-4672 NNP denotes TMZ
T3364 4673-4683 NN denotes resistance
T3365 4684-4687 IN denotes via
T3366 4688-4690 DT denotes an
T3367 4691-4706 JJ denotes NF-κB-dependent
T3368 4707-4716 NN denotes mechanism
T3369 4717-4718 -LRB- denotes (
T3370 4718-4723 NNP denotes Huang
T3371 4724-4726 FW denotes et
T3372 4727-4730 FW denotes al.
T3373 4730-4731 , denotes ,
T3374 4732-4736 CD denotes 2012
T3375 4736-4737 -RRB- denotes )
T3376 4737-4738 . denotes .
T3377 4739-4744 CD denotes STAT3
T3378 4745-4754 NN denotes inhibitor
T3379 4755-4757 CC denotes or
T3380 4758-4763 CD denotes STAT3
T3381 4764-4773 JJ denotes knockdown
T3382 4774-4785 NNS denotes potentiates
T3383 4786-4789 NNP denotes TMZ
T3384 4790-4798 NN denotes efficacy
T3385 4799-4801 IN denotes in
T3386 4802-4811 JJ denotes resistant
T3387 4812-4815 NNP denotes GBM
T3388 4816-4820 NN denotes cell
T3389 4821-4826 NNS denotes lines
T3390 4827-4828 -LRB- denotes (
T3391 4828-4835 NNP denotes Kohsaka
T3392 4836-4838 FW denotes et
T3393 4839-4842 FW denotes al.
T3394 4842-4843 , denotes ,
T3395 4844-4848 CD denotes 2012
T3396 4848-4849 -RRB- denotes )
T3397 4849-4850 . denotes .
T3398 4851-4863 NNP denotes Intratumoral
T3399 4864-4871 NN denotes hypoxia
T3400 4872-4874 VBZ denotes is
T3401 4875-4881 JJ denotes common
T3402 4882-4884 IN denotes in
T3403 4885-4889 NNS denotes GBMs
T3404 4890-4893 CC denotes and
T3405 4894-4897 MD denotes may
T3406 4898-4900 VB denotes be
T3407 4901-4911 VBN denotes associated
T3408 4912-4916 IN denotes with
T3409 4917-4920 DT denotes the
T3410 4921-4932 NN denotes development
T3411 4933-4935 IN denotes of
T3412 4936-4939 NNP denotes TMZ
T3413 4940-4950 NN denotes resistance
T3414 4950-4951 . denotes .
T3415 4952-4959 VBN denotes Induced
T3416 4960-4969 NN denotes hyperoxia
T3417 4970-4973 MD denotes can
T3418 4974-4976 VB denotes be
T3419 4977-4985 VBN denotes utilized
T3420 4986-4988 TO denotes to
T3421 4989-4996 VB denotes reverse
T3422 4997-5000 NNP denotes TMZ
T3423 5001-5011 NN denotes resistance
T3424 5012-5014 IN denotes in
T3425 5015-5019 NNS denotes GBMs
T3426 5020-5021 -LRB- denotes (
T3427 5021-5024 NNP denotes Sun
T3428 5025-5027 FW denotes et
T3429 5028-5031 FW denotes al.
T3430 5031-5032 , denotes ,
T3431 5033-5037 CD denotes 2012
T3432 5037-5038 -RRB- denotes )
T3433 5038-5039 . denotes .
T3434 5040-5046 NNP denotes Cancer
T3435 5047-5051 NN denotes stem
T3436 5052-5057 NNS denotes cells
T3437 5058-5061 VBP denotes are
T3438 5062-5070 RB denotes probably
T3439 5071-5074 DT denotes the
T3440 5075-5078 NN denotes key
T3441 5079-5081 TO denotes to
T3442 5082-5089 NN denotes failure
T3443 5090-5092 IN denotes in
T3444 5093-5096 NNP denotes TMZ
T3445 5097-5106 NN denotes treatment
T3446 5106-5107 . denotes .
T3447 5108-5111 DT denotes The
T3448 5112-5119 NN denotes concept
T3449 5120-5122 IN denotes of
T3450 5123-5129 NN denotes cancer
T3451 5130-5134 NN denotes stem
T3452 5135-5139 NN denotes cell
T3453 5140-5148 NN denotes survival
T3454 5149-5153 IN denotes from
T3455 5154-5163 NN denotes treatment
T3456 5164-5168 IN denotes with
T3457 5169-5172 NNP denotes TMZ
T3458 5173-5176 CC denotes and
T3459 5177-5182 JJ denotes other
T3460 5183-5199 JJ denotes chemotherapeutic
T3461 5200-5205 NNS denotes drugs
T3462 5206-5209 VBZ denotes has
T3463 5210-5214 VBN denotes been
T3464 5215-5219 RBR denotes more
T3465 5220-5231 JJ denotes complicated
T3466 5232-5236 IN denotes than
T3467 5237-5247 RB denotes previously
T3468 5248-5255 VBN denotes thought
T3469 5256-5257 -LRB- denotes (
T3470 5257-5262 NNP denotes Beier
T3471 5263-5265 FW denotes et
T3472 5266-5269 FW denotes al.
T3473 5269-5270 , denotes ,
T3474 5271-5275 CD denotes 2011
T3475 5275-5276 : denotes ;
T3476 5277-5281 NNP denotes Chen
T3477 5282-5284 FW denotes et
T3478 5285-5288 FW denotes al.
T3479 5288-5289 , denotes ,
T3480 5290-5294 CD denotes 2012
T3481 5294-5295 -RRB- denotes )
T3482 5295-5296 . denotes .
T3483 5297-5311 JJ denotes CD133-positive
T3484 5312-5318 NN denotes cancer
T3485 5319-5323 NN denotes stem
T3486 5324-5329 NNS denotes cells
T3487 5330-5333 VBP denotes are
T3488 5334-5343 VBN denotes expressed
T3489 5344-5346 IN denotes in
T3490 5347-5351 DT denotes both
T3491 5352-5358 JJ denotes normal
T3492 5359-5363 NN denotes stem
T3493 5364-5369 NNS denotes cells
T3494 5370-5373 CC denotes and
T3495 5374-5380 NN denotes cancer
T3496 5381-5385 NN denotes stem
T3497 5386-5391 NNS denotes cells
T3498 5392-5393 -LRB- denotes (
T3499 5393-5400 NNP denotes Donovan
T3500 5401-5404 CC denotes and
T3501 5405-5415 NNP denotes Pilkington
T3502 5415-5416 , denotes ,
T3503 5417-5421 CD denotes 2012
T3504 5421-5422 -RRB- denotes )
T3505 5422-5423 . denotes .
T3506 5424-5431 RB denotes However
T3507 5431-5432 , denotes ,
T3508 5433-5436 DT denotes the
T3509 5437-5441 NN denotes role
T3510 5442-5444 IN denotes of
T3511 5445-5450 NNP denotes CD133
T3512 5451-5453 IN denotes as
T3513 5454-5455 DT denotes a
T3514 5456-5462 NN denotes marker
T3515 5463-5466 IN denotes for
T3516 5467-5473 NN denotes glioma
T3517 5474-5480 NN denotes cancer
T3518 5481-5485 NN denotes stem
T3519 5486-5491 NNS denotes cells
T3520 5492-5500 JJ denotes relative
T3521 5501-5503 TO denotes to
T3522 5504-5507 PRP$ denotes its
T3523 5508-5518 JJ denotes biological
T3524 5519-5527 NN denotes function
T3525 5528-5531 VBZ denotes has
T3526 5532-5535 RB denotes yet
T3527 5536-5538 TO denotes to
T3528 5539-5541 VB denotes be
T3529 5542-5553 VBN denotes established
T3530 5553-5554 . denotes .
T5771 5597-5605 RB denotes Recently
T5772 5605-5606 , denotes ,
T5773 5607-5612 NN denotes tumor
T5774 5613-5624 NNS denotes suppressors
T5775 5625-5628 NN denotes p53
T5776 5629-5632 CC denotes and
T5777 5633-5637 NNP denotes WWOX
T5778 5638-5642 VBD denotes were
T5779 5643-5648 VBN denotes shown
T5780 5649-5651 TO denotes to
T5781 5652-5660 VB denotes regulate
T5782 5661-5664 DT denotes the
T5783 5665-5674 NN denotes apoptosis
T5784 5675-5677 IN denotes of
T5785 5678-5690 NN denotes glioblastoma
T5786 5691-5696 NNS denotes cells
T5787 5697-5698 -LRB- denotes (
T5788 5698-5704 NNP denotes Chiang
T5789 5705-5707 FW denotes et
T5790 5708-5711 FW denotes al.
T5791 5711-5712 , denotes ,
T5792 5713-5717 CD denotes 2012
T5793 5717-5718 -RRB- denotes )
T5794 5718-5719 . denotes .
T5795 5720-5722 NNP denotes WW
T5796 5723-5740 JJ denotes domain-containing
T5797 5741-5755 NN denotes oxidoreductase
T5798 5755-5756 , denotes ,
T5799 5757-5762 VBN denotes known
T5800 5763-5765 IN denotes as
T5801 5766-5770 NNP denotes WWOX
T5802 5770-5771 , denotes ,
T5803 5772-5775 IN denotes FOR
T5804 5775-5776 , denotes ,
T5805 5777-5779 CC denotes or
T5806 5780-5784 NNP denotes WOX1
T5807 5784-5785 , denotes ,
T5808 5786-5788 VBZ denotes is
T5809 5789-5796 VBN denotes encoded
T5810 5797-5799 IN denotes by
T5811 5800-5805 JJ denotes human
T5812 5806-5808 CC denotes or
T5813 5809-5814 NN denotes mouse
T5814 5815-5824 NNP denotes WWOX/Wwox
T5815 5825-5829 NN denotes gene
T5816 5829-5830 . denotes .
T5817 5831-5835 DT denotes This
T5818 5836-5840 NN denotes gene
T5819 5841-5843 VBZ denotes is
T5820 5844-5851 VBN denotes located
T5821 5852-5854 IN denotes in
T5822 5855-5865 NN denotes chromosome
T5823 5866-5871 CD denotes 16q23
T5824 5871-5873 CD denotes .3
T5825 5874-5878 CD denotes 24.1
T5826 5878-5879 , denotes ,
T5827 5880-5882 DT denotes an
T5828 5883-5887 NN denotes area
T5829 5888-5893 VBN denotes known
T5830 5894-5896 IN denotes as
T5831 5897-5900 DT denotes the
T5832 5901-5907 JJ denotes common
T5833 5908-5915 JJ denotes fragile
T5834 5916-5920 NN denotes site
T5835 5921-5927 CD denotes FRA16D
T5836 5927-5928 . denotes .
T5837 5929-5932 DT denotes The
T5838 5933-5944 JJ denotes full-length
T5839 5945-5949 NNP denotes WWOX
T5840 5950-5957 NN denotes protein
T5841 5958-5960 VBZ denotes is
T5842 5961-5969 VBN denotes composed
T5843 5970-5972 IN denotes of
T5844 5973-5976 CD denotes two
T5845 5977-5987 JJ denotes N-terminal
T5846 5988-5990 NNP denotes WW
T5847 5991-5998 NNS denotes domains
T5848 5998-5999 , denotes ,
T5849 6000-6001 DT denotes a
T5850 6002-6012 JJ denotes C-terminal
T5851 6013-6024 NN denotes short-chain
T5852 6025-6032 NN denotes alcohol
T5853 6033-6056 NN denotes dehydrogenase/reductase
T5854 6057-6058 -LRB- denotes (
T5855 6058-6061 NNP denotes SDR
T5856 6061-6062 -RRB- denotes )
T5857 6063-6069 NN denotes domain
T5858 6069-6070 , denotes ,
T5859 6071-6074 CC denotes and
T5860 6075-6076 DT denotes a
T5861 6077-6089 JJ denotes proapoptotic
T5862 6090-6100 JJ denotes C-terminal
T5863 6101-6105 NN denotes tail
T5864 6106-6108 NN denotes D3
T5865 6109-6110 -LRB- denotes (
T5866 6110-6115 NNP denotes Chang
T5867 6116-6118 FW denotes et
T5868 6119-6122 FW denotes al.
T5869 6122-6123 , denotes ,
T5870 6124-6128 CD denotes 2001
T5871 6128-6129 , denotes ,
T5872 6130-6134 CD denotes 2007
T5873 6134-6135 , denotes ,
T5874 6136-6140 CD denotes 2010
T5875 6140-6141 : denotes ;
T5876 6142-6149 NNP denotes Aqeilan
T5877 6150-6152 FW denotes et
T5878 6153-6156 FW denotes al.
T5879 6156-6157 , denotes ,
T5880 6158-6162 CD denotes 2004
T5881 6162-6163 , denotes ,
T5882 6164-6168 CD denotes 2007
T5883 6168-6169 : denotes ;
T5884 6170-6174 NNP denotes Hong
T5885 6175-6177 FW denotes et
T5886 6178-6181 FW denotes al.
T5887 6181-6182 , denotes ,
T5888 6183-6187 CD denotes 2007
T5889 6187-6188 : denotes ;
T5890 6189-6194 NNP denotes Salah
T5891 6195-6197 FW denotes et
T5892 6198-6201 FW denotes al.
T5893 6201-6202 , denotes ,
T5894 6203-6207 CD denotes 2012
T5895 6207-6208 -RRB- denotes )
T5896 6209-6210 -LRB- denotes (
T5897 6210-6216 NN denotes Figure
T5898 6217-6218 CD denotes 1
T5899 6218-6219 -RRB- denotes )
T5900 6219-6220 . denotes .
T5901 6221-6225 NNP denotes WWOX
T5902 6226-6229 MD denotes may
T5903 6230-6233 VB denotes act
T5904 6234-6236 IN denotes as
T5905 6237-6239 DT denotes an
T5906 6240-6251 NN denotes alternative
T5907 6252-6260 NN denotes receptor
T5908 6261-6264 IN denotes for
T5909 6265-6268 NN denotes sex
T5910 6269-6276 JJ denotes steroid
T5911 6277-6285 NNS denotes hormones
T5912 6285-6286 , denotes ,
T5913 6287-6292 IN denotes since
T5914 6293-6296 PRP$ denotes its
T5915 6297-6300 NNP denotes SDR
T5916 6301-6307 NN denotes domain
T5917 6308-6317 VBZ denotes possesses
T5918 6318-6320 DT denotes an
T5919 6321-6325 NNP denotes NSYK
T5920 6326-6331 NN denotes motif
T5921 6332-6339 JJ denotes capable
T5922 6340-6342 IN denotes of
T5923 6343-6354 VBG denotes interacting
T5924 6355-6359 IN denotes with
T5925 6360-6368 NN denotes androgen
T5926 6369-6372 CC denotes and
T5927 6373-6381 NN denotes estrogen
T5928 6382-6383 -LRB- denotes (
T5929 6383-6388 NNP denotes Chang
T5930 6389-6391 FW denotes et
T5931 6392-6395 FW denotes al.
T5932 6395-6396 , denotes ,
T5933 6397-6402 JJ denotes 2005a
T5934 6402-6403 : denotes ;
T5935 6404-6406 NNP denotes Su
T5936 6407-6409 FW denotes et
T5937 6410-6413 FW denotes al.
T5938 6413-6414 , denotes ,
T5939 6415-6419 CD denotes 2012
T5940 6419-6420 -RRB- denotes )
T5941 6420-6421 . denotes .
T13557 6432-6441 JJ denotes Schematic
T13558 6442-6450 NNS denotes diagrams
T13559 6451-6453 IN denotes of
T13560 6454-6458 NNP denotes WWOX
T13561 6459-6468 NN denotes structure
T13562 6469-6472 CC denotes and
T13563 6473-6476 PRP$ denotes its
T13564 6477-6481 NN denotes role
T13565 6482-6484 IN denotes in
T13566 6485-6494 VBG denotes signaling
T13567 6494-6495 . denotes .
T13568 6496-6500 NNP denotes WWOX
T13569 6501-6509 VBZ denotes contains
T13570 6510-6513 CD denotes two
T13571 6514-6524 JJ denotes N-terminal
T13572 6525-6527 NNP denotes WW
T13573 6528-6535 NNS denotes domains
T13574 6535-6536 , denotes ,
T13575 6537-6538 DT denotes a
T13576 6539-6549 JJ denotes C-terminal
T13577 6550-6561 NN denotes short-chain
T13578 6562-6569 NN denotes alcohol
T13579 6570-6593 NN denotes dehydrogenase/reductase
T13580 6594-6595 -LRB- denotes (
T13581 6595-6598 NNP denotes SDR
T13582 6598-6599 -RRB- denotes )
T13583 6600-6606 NN denotes domain
T13584 6606-6607 , denotes ,
T13585 6608-6611 CC denotes and
T13586 6612-6613 DT denotes a
T13587 6614-6616 JJ denotes D3
T13588 6617-6623 NN denotes region
T13589 6623-6624 . denotes .
T13590 6625-6626 DT denotes A
T13591 6627-6634 JJ denotes nuclear
T13592 6635-6647 NN denotes localization
T13593 6648-6654 NN denotes signal
T13594 6655-6656 -LRB- denotes (
T13595 6656-6659 NNP denotes NLS
T13596 6659-6660 -RRB- denotes )
T13597 6661-6663 VBZ denotes is
T13598 6664-6666 IN denotes in
T13599 6667-6674 IN denotes between
T13600 6675-6678 DT denotes the
T13601 6679-6681 NNP denotes WW
T13602 6682-6689 NNS denotes domains
T13603 6690-6691 -LRB- denotes (
T13604 6691-6696 NNP denotes Chang
T13605 6697-6699 FW denotes et
T13606 6700-6703 FW denotes al.
T13607 6703-6704 , denotes ,
T13608 6705-6709 CD denotes 2003
T13609 6709-6710 , denotes ,
T13610 6711-6715 CD denotes 2007
T13611 6715-6716 : denotes ;
T13612 6717-6720 NNP denotes Del
T13613 6721-6725 NNP denotes Mare
T13614 6726-6728 FW denotes et
T13615 6729-6732 FW denotes al.
T13616 6732-6733 , denotes ,
T13617 6734-6738 CD denotes 2011
T13618 6738-6739 : denotes ;
T13619 6740-6745 NNP denotes Salah
T13620 6746-6748 FW denotes et
T13621 6749-6752 FW denotes al.
T13622 6752-6753 , denotes ,
T13623 6754-6758 CD denotes 2012
T13624 6758-6759 : denotes ;
T13625 6760-6762 NNP denotes Su
T13626 6763-6765 FW denotes et
T13776 6766-6769 FW denotes al.
T13777 6769-6770 , denotes ,
T13778 6771-6775 CD denotes 2012
T13779 6775-6776 : denotes ;
T13780 6777-6784 NNS denotes reviews
T13781 6784-6785 -RRB- denotes )
T13782 6785-6786 . denotes .
T13783 6787-6790 DT denotes The
T13784 6791-6794 NNP denotes SDR
T13785 6795-6801 NN denotes domain
T13786 6802-6811 VBZ denotes possesses
T13787 6812-6813 DT denotes a
T13788 6814-6834 JJ denotes mitochondria-binding
T13789 6835-6841 NN denotes region
T13790 6841-6842 . denotes .
T13791 6843-6848 EX denotes There
T13792 6849-6852 VBP denotes are
T13793 6853-6856 CD denotes two
T13794 6857-6866 JJ denotes conserved
T13795 6867-6875 NN denotes tyrosine
T13796 6876-6891 NN denotes phosphorylation
T13797 6892-6897 NNS denotes sites
T13798 6897-6898 , denotes ,
T13799 6899-6904 NNP denotes Tyr33
T13800 6905-6908 CC denotes and
T13801 6909-6915 NNP denotes Tyr287
T13802 6915-6916 . denotes .
T13803 6917-6922 JJ denotes Other
T13804 6923-6938 NN denotes phosphorylation
T13805 6939-6944 NNS denotes sites
T13806 6945-6954 VBN denotes predicted
T13807 6955-6957 IN denotes by
T13808 6958-6965 NNP denotes NetPhos
T13809 6966-6969 CD denotes 2.0
T13810 6970-6976 NNP denotes Server
T13811 6977-6980 VBP denotes are
T13812 6981-6985 NNP denotes Tyr6
T13813 6985-6986 , denotes ,
T13814 6987-6992 NNP denotes Thr12
T13815 6992-6993 , denotes ,
T13816 6994-6999 NNP denotes Ser14
T13817 6999-7000 , denotes ,
T13818 7001-7006 NNP denotes Tyr61
T13819 7006-7007 , denotes ,
T13820 7008-7014 NNP denotes Tyr293
T13821 7014-7015 , denotes ,
T13822 7016-7019 CC denotes and
T13823 7020-7026 NNP denotes Thr3B3
T13824 7026-7027 , denotes ,
T13825 7028-7040 RB denotes respectively
T13826 7040-7041 . denotes .
T13827 7042-7046 IN denotes Upon
T13828 7047-7053 NN denotes stress
T13829 7054-7065 NN denotes stimulation
T13830 7065-7066 , denotes ,
T13831 7067-7071 NNP denotes WWOX
T13832 7072-7074 VBZ denotes is
T13833 7075-7089 VBN denotes phosphorylated
T13834 7090-7092 IN denotes in
T13835 7093-7098 CD denotes Tyr33
T13836 7099-7102 CC denotes and
T13837 7103-7108 VBZ denotes binds
T13838 7109-7112 NN denotes p53
T13839 7112-7113 . denotes .
T13840 7114-7117 DT denotes The
T13841 7118-7126 JJ denotes WWOX/p53
T13842 7127-7134 JJ denotes complex
T13843 7135-7139 RB denotes then
T13844 7140-7152 VBZ denotes translocates
T13845 7153-7155 TO denotes to
T13846 7156-7168 VB denotes mitochondria
T13847 7169-7171 CC denotes or
T13848 7172-7179 NN denotes nucleus
T13849 7180-7182 TO denotes to
T13850 7183-7189 VB denotes induce
T13851 7190-7199 NN denotes apoptosis
T13852 7199-7200 . denotes .
T13853 7201-7205 NNP denotes WWOX
T13854 7206-7210 RB denotes also
T13855 7211-7216 VBZ denotes binds
T13856 7217-7221 NNP denotes PPxY
T13857 7222-7238 NN denotes motif-containing
T13858 7239-7252 NN denotes transcription
T13859 7253-7260 NNS denotes factors
T13860 7260-7261 , denotes ,
T13861 7262-7266 JJ denotes such
T13862 7267-7269 IN denotes as
T13863 7270-7275 NNP denotes RUNX2
T13864 7275-7276 , denotes ,
T13865 7277-7282 NNP denotes c-Jun
T13866 7282-7283 , denotes ,
T13867 7284-7287 CC denotes and
T13868 7288-7293 NNP denotes ERBB4
T13869 7293-7294 , denotes ,
T13870 7295-7298 IN denotes via
T13871 7299-7302 PRP$ denotes its
T13872 7303-7308 JJ denotes first
T13873 7309-7311 NNP denotes WW
T13874 7312-7318 NN denotes domain
T13875 7318-7319 , denotes ,
T13876 7320-7323 CC denotes and
T13877 7324-7327 DT denotes the
T13878 7328-7335 JJ denotes binding
T13879 7336-7342 NNS denotes blocks
T13880 7343-7346 DT denotes the
T13881 7347-7355 NN denotes activity
T13882 7356-7358 IN denotes of
T13883 7359-7364 DT denotes these
T13884 7365-7373 NNS denotes proteins
T13885 7374-7376 IN denotes by
T13886 7377-7386 VBG denotes retaining
T13887 7387-7391 PRP denotes them
T13888 7392-7394 IN denotes in
T13889 7395-7398 DT denotes the
T13890 7399-7408 NN denotes cytoplasm
T13891 7408-7409 . denotes .
T13892 7410-7414 NNP denotes WWOX
T13893 7415-7420 VBZ denotes binds
T13894 7421-7424 NNP denotes Tau
T13895 7425-7428 IN denotes via
T13896 7429-7432 PRP$ denotes its
T13897 7433-7436 NNP denotes SDR
T13898 7437-7443 NN denotes domain
T13899 7443-7444 . denotes .
T13900 7445-7449 NNP denotes WWOX
T13901 7450-7462 VBZ denotes participates
T13902 7463-7465 IN denotes in
T13903 7466-7469 DT denotes the
T13904 7470-7473 NNP denotes Wnt
T13905 7473-7474 NNP denotes /
T13906 7474-7483 JJ denotes β-catenin
T13907 7484-7490 NN denotes signal
T13908 7491-7498 NN denotes pathway
T13909 7499-7501 IN denotes by
T13910 7502-7509 JJ denotes binding
T13911 7510-7513 NNP denotes Dvl
T13912 7514-7517 CC denotes and
T13913 7518-7528 VBG denotes inhibiting
T13914 7529-7532 PRP$ denotes its
T13915 7533-7540 JJ denotes nuclear
T13916 7541-7547 NN denotes import
T13917 7547-7548 . denotes .
T13918 7549-7556 NNP denotes Phorbol
T13919 7557-7562 NN denotes ester
T13920 7563-7573 VBZ denotes stimulates
T13921 7574-7577 DT denotes the
T13922 7578-7590 NN denotes dissociation
T13923 7591-7593 IN denotes of
T13924 7594-7602 NNP denotes MEK/WWOX
T13925 7603-7610 NN denotes complex
T13926 7611-7613 IN denotes in
T13927 7614-7620 NNP denotes Jurkat
T13928 7621-7622 NNP denotes T
T13929 7623-7627 NN denotes cell
T13930 7627-7628 , denotes ,
T13931 7629-7632 CC denotes and
T13932 7633-7636 DT denotes the
T13933 7637-7645 VBN denotes released
T13934 7646-7650 NNP denotes WWOX
T13935 7651-7663 VBZ denotes translocates
T13936 7664-7666 TO denotes to
T13937 7667-7670 DT denotes the
T13938 7671-7683 NN denotes mitochondria
T13939 7684-7687 IN denotes for
T13940 7688-7695 VBG denotes causing
T13941 7696-7700 NN denotes cell
T13942 7701-7706 NN denotes death
T13943 7706-7707 . denotes .
T13944 7708-7712 NNP denotes WWOX
T13945 7713-7715 VBZ denotes is
T13946 7716-7725 VBN denotes recruited
T13947 7726-7728 TO denotes to
T13948 7729-7732 DT denotes the
T13949 7733-7741 NN denotes membrane
T13950 7742-7746 NN denotes area
T13951 7747-7749 IN denotes by
T13952 7750-7761 NN denotes association
T13953 7762-7766 IN denotes with
T13954 7767-7773 JJ denotes Hyal-2
T13955 7774-7777 CC denotes and
T13956 7778-7791 JJ denotes phospho-Ezrin
T13957 7791-7792 . denotes .
T13958 7793-7799 NN denotes Hyal-2
T13959 7800-7802 VBZ denotes is
T13960 7803-7805 DT denotes an
T13961 7806-7817 NN denotes alternative
T13962 7818-7826 NN denotes receptor
T13963 7827-7830 IN denotes for
T13964 7831-7837 NN denotes TGF-β1
T12940 7837-7838 . denotes .
T12941 7839-7841 IN denotes In
T12942 7842-7850 NN denotes response
T12943 7851-7853 TO denotes to
T12944 7854-7860 NNP denotes TGF-β1
T12945 7860-7861 , denotes ,
T12946 7862-7866 NNP denotes WWOX
T12947 7867-7872 VBZ denotes binds
T12948 7873-7879 NNP denotes Hyal-2
T12949 7880-7883 CC denotes and
T12950 7884-7889 NNS denotes forms
T12951 7890-7891 DT denotes a
T12952 7892-7899 NN denotes complex
T12953 7899-7900 , denotes ,
T12954 7901-7909 VBN denotes followed
T12955 7910-7912 IN denotes by
T12956 7913-7923 VBG denotes relocating
T12957 7924-7926 TO denotes to
T12958 7927-7930 DT denotes the
T12959 7931-7938 NN denotes nucleus
T12960 7939-7942 CC denotes and
T12961 7943-7952 VBG denotes enhancing
T12962 7953-7956 DT denotes the
T12963 7957-7968 JJ denotes SMAD-driven
T12964 7969-7977 NN denotes promoter
T12965 7978-7986 NN denotes activity
T12966 7986-7987 . denotes .
T12967 7988-7992 NNP denotes Ack1
T12968 7992-7993 , denotes ,
T12969 7994-8003 VBN denotes activated
T12970 8004-8020 JJ denotes Cdc42-associated
T12971 8021-8027 NN denotes kinase
T12972 8028-8029 CD denotes 1
T12973 8029-8030 : denotes ;
T12974 8031-8037 NNP denotes Hyal-2
T12975 8037-8038 , denotes ,
T12976 8039-8063 NN denotes hyaluronoglucosaminidase
T12977 8064-8065 CD denotes 2
T12978 8065-8066 : denotes ;
T12979 8067-8070 NNP denotes CKI
T12980 8070-8071 , denotes ,
T12981 8072-8078 NN denotes casein
T12982 8079-8085 NN denotes kinase
T12983 8085-8086 : denotes ;
T12984 8087-8090 NNP denotes GSK
T12985 8090-8091 , denotes ,
T12986 8092-8100 NN denotes glycogen
T12987 8101-8109 NN denotes synthase
T12988 8110-8116 NN denotes kinase
T12989 8116-8117 : denotes ;
T12990 8118-8121 NNP denotes PKA
T12991 8121-8122 , denotes ,
T12992 8123-8130 NN denotes protein
T12993 8131-8137 NN denotes kinase
T12994 8138-8140 NN denotes A.
T5942 8141-8151 NN denotes Expression
T5943 8152-8154 IN denotes of
T5944 8155-8159 NNP denotes WWOX
T5945 8160-8162 VBZ denotes is
T5946 8163-8169 RB denotes either
T5947 8170-8177 VBN denotes altered
T5948 8178-8180 CC denotes or
T5949 8181-8185 VBN denotes lost
T5950 8186-8190 IN denotes from
T5951 8191-8201 JJ denotes epigenetic
T5952 8202-8214 NN denotes modification
T5953 8215-8217 IN denotes in
T5954 8218-8226 JJ denotes multiple
T5955 8227-8236 JJ denotes malignant
T5956 8237-8244 NNS denotes cancers
T5957 8244-8245 , denotes ,
T5958 8246-8250 JJ denotes such
T5959 8251-8253 IN denotes as
T5960 8254-8263 JJ denotes non-small
T5961 8264-8268 NN denotes cell
T5962 8269-8273 NN denotes lung
T5963 8274-8283 NN denotes carcinoma
T5964 8284-8285 -LRB- denotes (
T5965 8285-8291 NNP denotes Donati
T5966 8292-8294 FW denotes et
T5967 8295-8298 FW denotes al.
T5968 8298-8299 , denotes ,
T5969 8300-8304 CD denotes 2007
T5970 8304-8305 -RRB- denotes )
T5971 8305-8306 , denotes ,
T5972 8307-8320 JJ denotes hematopoietic
T5973 8321-8333 NNS denotes malignancies
T5974 8334-8335 -LRB- denotes (
T5975 8335-8340 NNP denotes Ishii
T5976 8341-8344 CC denotes and
T5977 8345-8353 NNP denotes Furukawa
T5978 8353-8354 , denotes ,
T5979 8355-8359 CD denotes 2004
T5980 8359-8360 -RRB- denotes )
T5981 8360-8361 , denotes ,
T5982 8362-8369 JJ denotes gastric
T5983 8370-8379 NN denotes carcinoma
T5984 8380-8381 -LRB- denotes (
T5985 8381-8388 JJ denotes Aqeilan
T5986 8389-8391 FW denotes et
T5987 8392-8395 FW denotes al.
T5988 8395-8396 , denotes ,
T5989 8397-8401 CD denotes 2004
T5990 8401-8402 -RRB- denotes )
T5991 8402-8403 , denotes ,
T5992 8404-8414 JJ denotes pancreatic
T5993 8415-8424 NN denotes carcinoma
T5994 8425-8426 -LRB- denotes (
T5995 8426-8432 NNP denotes Kuroki
T5996 8433-8435 FW denotes et
T5997 8436-8439 FW denotes al.
T5998 8439-8440 , denotes ,
T5999 8441-8445 CD denotes 2004
T6000 8445-8446 -RRB- denotes )
T6001 8446-8447 , denotes ,
T6002 8448-8454 NN denotes breast
T6003 8455-8464 NN denotes carcinoma
T6004 8465-8466 -LRB- denotes (
T6005 8466-8471 NNP denotes Guler
T6006 8472-8474 FW denotes et
T6007 8475-8478 FW denotes al.
T6008 8478-8479 , denotes ,
T6009 8480-8484 CD denotes 2004
T6010 8484-8485 : denotes ;
T6011 8486-8493 NNP denotes Aqeilan
T6012 8494-8496 FW denotes et
T6013 8497-8500 FW denotes al.
T6014 8500-8501 , denotes ,
T6015 8502-8506 CD denotes 2007
T6016 8506-8507 -RRB- denotes )
T6017 8507-8508 , denotes ,
T6018 8509-8512 CC denotes and
T6019 8513-8525 NN denotes glioblastoma
T6020 8526-8536 NNS denotes multiforme
T6021 8537-8538 -LRB- denotes (
T6022 8538-8543 NNP denotes Kosla
T6023 8544-8546 FW denotes et
T6024 8547-8550 FW denotes al.
T6025 8550-8551 , denotes ,
T6026 8552-8556 CD denotes 2011
T6027 8556-8557 -RRB- denotes )
T6028 8557-8558 . denotes .
T6029 8559-8570 NNP denotes Restoration
T6030 8571-8573 IN denotes of
T6031 8574-8578 NNP denotes WWOX
T6032 8579-8583 NN denotes gene
T6033 8584-8592 VBZ denotes prevents
T6034 8593-8596 DT denotes the
T6035 8597-8603 NN denotes growth
T6036 8604-8606 IN denotes of
T6037 8607-8611 NN denotes lung
T6038 8612-8618 NN denotes cancer
T6039 8619-8620 -LRB- denotes (
T6040 8620-8626 NNP denotes Fabbri
T6041 8627-8629 FW denotes et
T6042 8630-8633 FW denotes al.
T6043 8633-8634 , denotes ,
T6044 8635-8639 CD denotes 2005
T6045 8639-8640 -RRB- denotes )
T6046 8640-8641 , denotes ,
T6047 8642-8652 JJ denotes pancreatic
T6048 8653-8659 NN denotes cancer
T6049 8660-8661 -LRB- denotes (
T6050 8661-8669 NNP denotes Nakayama
T6051 8670-8672 FW denotes et
T6052 8673-8676 FW denotes al.
T6053 8676-8677 , denotes ,
T6054 8678-8682 CD denotes 2008
T6055 8682-8683 -RRB- denotes )
T6056 8683-8684 , denotes ,
T6057 8685-8688 CC denotes and
T6058 8689-8697 NN denotes prostate
T6059 8698-8704 NN denotes cancer
T6060 8705-8706 -LRB- denotes (
T6061 8706-8710 NNP denotes Hong
T6062 8711-8713 FW denotes et
T6063 8714-8717 FW denotes al.
T6064 8717-8718 , denotes ,
T6065 8719-8723 CD denotes 2009
T6066 8723-8724 -RRB- denotes )
T6067 8724-8725 . denotes .
T6068 8726-8729 DT denotes The
T6069 8730-8735 JJ denotes first
T6070 8736-8738 NNP denotes WW
T6071 8739-8745 NN denotes domain
T6072 8746-8748 IN denotes of
T6073 8749-8753 NNP denotes WWOX
T6074 8754-8757 MD denotes may
T6075 8758-8766 VB denotes interact
T6076 8767-8771 IN denotes with
T6077 8772-8780 NNS denotes proteins
T6078 8781-8791 VBG denotes possessing
T6079 8792-8793 DT denotes a
T6080 8794-8798 NNP denotes PPxY
T6081 8799-8804 NN denotes motif
T6082 8804-8805 -LRB- denotes (
T6083 8805-8806 PRP denotes s
T6084 8806-8807 -RRB- denotes )
T6085 8808-8812 JJ denotes such
T6086 8813-8815 IN denotes as
T6087 8816-8821 JJ denotes AP-2γ
T6088 8821-8822 , denotes ,
T6089 8823-8826 JJ denotes p73
T6090 8826-8827 , denotes ,
T6091 8828-8833 JJ denotes ErbB4
T6092 8833-8834 , denotes ,
T6093 8835-8840 NNP denotes Ezrin
T6094 8840-8841 , denotes ,
T6095 8842-8848 NNP denotes SIMPLE
T6096 8848-8849 , denotes ,
T6097 8850-8855 NNP denotes c-Jun
T6098 8855-8856 , denotes ,
T6099 8857-8862 NNP denotes RUNX4
T6100 8862-8863 , denotes ,
T6101 8864-8867 CC denotes and
T6102 8868-8872 JJ denotes many
T6103 8873-8879 NNS denotes others
T6104 8880-8881 -LRB- denotes (
T6105 8881-8886 NNP denotes Chang
T6106 8887-8889 FW denotes et
T6107 8890-8893 FW denotes al.
T6108 8893-8894 , denotes ,
T6109 8895-8899 CD denotes 2007
T6110 8899-8900 : denotes ;
T6111 8901-8906 NNP denotes Salah
T6112 8907-8909 FW denotes et
T6113 8910-8913 FW denotes al.
T6114 8913-8914 , denotes ,
T6115 8915-8919 CD denotes 2012
T6116 8919-8920 : denotes ;
T6117 8921-8923 NNP denotes Su
T6118 8924-8926 FW denotes et
T6119 8927-8930 FW denotes al.
T6120 8930-8931 , denotes ,
T6121 8932-8936 CD denotes 2012
T6122 8936-8937 : denotes ;
T6123 8938-8944 NN denotes Figure
T6124 8945-8946 CD denotes 1
T6125 8946-8947 -RRB- denotes )
T6126 8947-8948 . denotes .
T6127 8949-8960 RB denotes Transiently
T6128 8961-8974 VBN denotes overexpressed
T6129 8975-8979 NNP denotes WWOX
T6130 8980-8985 VBZ denotes binds
T6131 8986-8999 NN denotes transcription
T6132 9000-9007 NNS denotes factors
T6133 9008-9012 NNP denotes AP-2
T6134 9012-9013 , denotes ,
T6135 9014-9017 CD denotes p73
T6136 9017-9018 , denotes ,
T6137 9019-9022 CC denotes and
T6138 9023-9028 NNP denotes c-Jun
T6139 9029-9032 CC denotes and
T6140 9033-9038 VB denotes block
T6141 9039-9044 PRP$ denotes their
T6142 9045-9052 JJ denotes nuclear
T6143 9053-9063 NN denotes relocation
T6144 9064-9066 IN denotes in
T6145 9067-9072 NN denotes vitro
T6146 9072-9073 , denotes ,
T6147 9074-9079 WDT denotes which
T6148 9080-9090 VBZ denotes suppresses
T6149 9091-9097 NN denotes cancer
T6150 9098-9102 NN denotes cell
T6151 9103-9111 NN denotes survival
T6152 9112-9113 -LRB- denotes (
T6153 9113-9118 JJ denotes Salah
T6154 9119-9121 FW denotes et
T6155 9122-9125 FW denotes al.
T6156 9125-9126 , denotes ,
T6157 9127-9131 CD denotes 2012
T6158 9131-9132 -RRB- denotes )
T6159 9132-9133 . denotes .
T6160 9134-9136 IN denotes In
T6161 9137-9142 JJ denotes stark
T6162 9143-9151 NN denotes contrast
T6163 9151-9152 , denotes ,
T6164 9153-9157 NNP denotes Wwox
T6165 9158-9169 NNS denotes co-migrates
T6166 9170-9174 IN denotes with
T6167 9175-9187 JJ denotes proapoptotic
T6168 9188-9191 CC denotes and
T6169 9192-9204 JJ denotes pro-survival
T6170 9205-9218 NN denotes transcription
T6171 9219-9226 NNS denotes factors
T6172 9227-9229 TO denotes to
T6173 9230-9233 DT denotes the
T6174 9234-9240 NN denotes nuclei
T6175 9241-9243 IN denotes of
T6176 9244-9251 NNS denotes neurons
T6177 9252-9256 IN denotes upon
T6178 9257-9264 JJ denotes sciatic
T6179 9265-9270 NN denotes nerve
T6180 9271-9278 NN denotes axotomy
T6181 9279-9281 IN denotes in
T6182 9282-9286 NNS denotes rats
T6183 9287-9288 -LRB- denotes (
T6184 9288-9290 NNP denotes Li
T6185 9291-9293 FW denotes et
T6186 9294-9297 FW denotes al.
T6187 9297-9298 , denotes ,
T6188 9299-9303 CD denotes 2009
T6189 9303-9304 -RRB- denotes )
T6190 9304-9305 . denotes .
T6191 9306-9308 DT denotes No
T6192 9309-9317 VBG denotes blocking
T6193 9318-9320 IN denotes of
T6194 9321-9334 NN denotes translocation
T6195 9335-9337 IN denotes of
T6196 9338-9351 NN denotes transcription
T6197 9352-9359 NNS denotes factors
T6198 9360-9362 TO denotes to
T6199 9363-9366 DT denotes the
T6200 9367-9373 NN denotes nuclei
T6201 9374-9376 IN denotes by
T6202 9377-9381 NNP denotes Wwox
T6203 9382-9385 VBD denotes was
T6204 9386-9394 VBN denotes observed
T6205 9394-9395 . denotes .
T6206 9396-9401 IN denotes Under
T6207 9402-9408 NN denotes stress
T6208 9409-9419 NNS denotes conditions
T6209 9419-9420 , denotes ,
T6210 9421-9425 NNP denotes WWOX
T6211 9426-9428 VBZ denotes is
T6212 9429-9438 VBN denotes activated
T6213 9439-9442 IN denotes via
T6214 9443-9458 NN denotes phosphorylation
T6215 9459-9461 IN denotes at
T6216 9462-9467 NNP denotes Tyr33
T6217 9467-9468 , denotes ,
T6218 9469-9472 CC denotes and
T6219 9473-9478 VBZ denotes binds
T6220 9479-9487 NNS denotes proteins
T6221 9488-9501 RB denotes independently
T6222 9502-9504 IN denotes of
T6223 9505-9508 DT denotes the
T6224 9509-9513 NNP denotes PPxY
T6225 9514-9519 NN denotes motif
T6226 9520-9521 -LRB- denotes (
T6227 9521-9526 NNP denotes Chang
T6228 9527-9529 FW denotes et
T6229 9530-9533 FW denotes al.
T6230 9533-9534 , denotes ,
T6231 9535-9539 CD denotes 2001
T6232 9539-9540 , denotes ,
T6233 9541-9545 CD denotes 2003
T6234 9545-9546 , denotes ,
T6235 9547-9552 CD denotes 2005a
T6236 9552-9553 , denotes ,
T6237 9553-9554 NN denotes b
T6238 9554-9555 , denotes ,
T6239 9556-9560 CD denotes 2007
T6240 9560-9561 , denotes ,
T6241 9562-9566 CD denotes 2010
T6242 9566-9567 -RRB- denotes )
T6243 9567-9568 . denotes .
T6244 9569-9578 VBN denotes Activated
T6245 9579-9583 NNP denotes WWOX
T6246 9584-9594 RB denotes physically
T6247 9595-9604 VBZ denotes interacts
T6248 9605-9609 IN denotes with
T6249 9610-9616 NN denotes serine
T6250 9617-9634 JJ denotes 46-phosphorylated
T6251 9635-9638 NN denotes p53
T6252 9639-9640 -LRB- denotes (
T6253 9640-9646 NN denotes Figure
T6254 9647-9648 CD denotes 1
T6255 9648-9649 -RRB- denotes )
T6256 9649-9650 , denotes ,
T6257 9651-9656 WDT denotes which
T6258 9657-9667 VBZ denotes stabilizes
T6259 9668-9671 NN denotes p53
T6260 9672-9675 CC denotes and
T6261 9676-9679 PRP$ denotes its
T6262 9680-9689 JJ denotes apoptotic
T6263 9690-9698 NN denotes function
T6264 9699-9700 -LRB- denotes (
T6265 9700-9705 NNP denotes Chang
T6266 9706-9708 FW denotes et
T6267 9709-9712 FW denotes al.
T6268 9712-9713 , denotes ,
T6269 9714-9719 JJ denotes 2005b
T6270 9719-9720 -RRB- denotes )
T6271 9720-9721 . denotes .
T6272 9722-9726 RB denotes Also
T6273 9726-9727 , denotes ,
T6274 9728-9732 NNP denotes WWOX
T6275 9733-9738 VBZ denotes binds
T6276 9739-9749 JJ denotes Disheveled
T6277 9750-9758 NNS denotes proteins
T6278 9759-9760 -LRB- denotes (
T6279 9760-9763 NNP denotes Dvl
T6280 9763-9764 -RRB- denotes )
T6281 9764-9765 , denotes ,
T6282 9766-9771 WDT denotes which
T6283 9772-9775 VBP denotes are
T6284 9776-9779 JJ denotes key
T6285 9780-9790 NNS denotes components
T6286 9791-9793 IN denotes in
T6287 9794-9797 NNP denotes Wnt
T6288 9797-9798 NNP denotes /
T6289 9798-9807 JJ denotes β-catenin
T6290 9808-9817 VBG denotes signaling
T6291 9818-9825 NN denotes pathway
T6292 9826-9827 -LRB- denotes (
T6293 9827-9833 NN denotes Figure
T6294 9834-9835 CD denotes 1
T6295 9835-9836 -RRB- denotes )
T6296 9836-9837 . denotes .
T6297 9838-9840 DT denotes No
T6298 9841-9845 NN denotes PPxY
T6299 9846-9851 NN denotes motif
T6300 9852-9854 VBZ denotes is
T6301 9855-9857 IN denotes in
T6302 9858-9861 NNP denotes Dvl
T6303 9861-9862 . denotes .
T6304 9863-9874 RB denotes Transiently
T6305 9875-9888 VBN denotes overexpressed
T6306 9889-9893 NNP denotes WWOX
T6307 9894-9904 NNS denotes sequesters
T6308 9905-9910 NN denotes Dvl-2
T6309 9911-9913 IN denotes in
T6310 9914-9917 DT denotes the
T6311 9918-9927 NN denotes cytoplasm
T6312 9928-9931 CC denotes and
T6313 9932-9939 RB denotes thereby
T6314 9940-9946 NNS denotes blocks
T6315 9947-9961 JJ denotes Dvl-2-mediated
T6316 9962-9965 NNP denotes TCF
T6317 9966-9981 JJ denotes transcriptional
T6318 9982-9990 NN denotes activity
T6319 9991-9992 -LRB- denotes (
T6320 9992-10001 NNP denotes Bouteille
T6321 10002-10004 FW denotes et
T6322 10005-10008 FW denotes al.
T6323 10008-10009 , denotes ,
T6324 10010-10014 CD denotes 2009
T6325 10014-10015 -RRB- denotes )
T6326 10015-10016 . denotes .
T6327 10017-10030 NNP denotes Overexpressed
T6328 10031-10035 NNP denotes WWOX
T6329 10036-10043 VBZ denotes induces
T6330 10044-10053 NN denotes apoptosis
T6331 10054-10057 CC denotes and
T6332 10058-10066 NNS denotes inhibits
T6333 10067-10080 NN denotes proliferation
T6334 10081-10083 IN denotes of
T6335 10084-10089 JJ denotes human
T6336 10090-10097 JJ denotes hepatic
T6337 10098-10107 NN denotes carcinoma
T6338 10108-10113 NNS denotes cells
T6339 10114-10115 -LRB- denotes (
T6340 10115-10117 NNP denotes Hu
T6341 10118-10120 FW denotes et
T6342 10121-10124 FW denotes al.
T6343 10124-10125 , denotes ,
T6344 10126-10130 CD denotes 2012
T6345 10130-10131 -RRB- denotes )
T6346 10132-10135 CC denotes and
T6347 10136-10140 JJ denotes many
T6348 10141-10147 NN denotes cancer
T6349 10148-10152 NN denotes cell
T6350 10153-10158 NNS denotes types
T6351 10159-10160 -LRB- denotes (
T6352 10160-10165 NNP denotes Chang
T6353 10166-10168 FW denotes et
T6354 10169-10172 FW denotes al.
T6355 10172-10173 , denotes ,
T6356 10174-10178 CD denotes 2007
T6357 10178-10179 , denotes ,
T6358 10180-10184 CD denotes 2010
T6359 10184-10185 : denotes ;
T6360 10186-10191 NNP denotes Salah
T6361 10192-10194 FW denotes et
T6362 10195-10198 FW denotes al.
T6363 10198-10199 , denotes ,
T6364 10200-10204 CD denotes 2012
T6365 10204-10205 : denotes ;
T6366 10206-10208 NNP denotes Su
T6367 10209-10211 FW denotes et
T6368 10212-10215 FW denotes al.
T6369 10215-10216 , denotes ,
T6370 10217-10221 CD denotes 2012
T6371 10221-10222 -RRB- denotes )
T6372 10222-10223 . denotes .
T6373 10224-10228 NNP denotes WWOX
T6374 10229-10237 VBZ denotes enhances
T6375 10238-10241 DT denotes the
T6376 10242-10251 JJ denotes cytotoxic
T6377 10252-10260 NN denotes function
T6378 10261-10263 IN denotes of
T6379 10264-10269 NN denotes tumor
T6380 10270-10278 NN denotes necrosis
T6381 10279-10285 NN denotes factor
T6382 10286-10288 IN denotes by
T6383 10289-10304 JJ denotes down-regulating
T6384 10305-10314 NN denotes apoptosis
T6385 10315-10324 NN denotes inhibitor
T6386 10325-10330 NN denotes Bcl-2
T6387 10331-10334 CC denotes and
T6388 10335-10341 JJ denotes Bcl-xL
T6389 10342-10345 CC denotes and
T6390 10346-10359 JJ denotes up-regulating
T6391 10360-10369 JJ denotes apoptotic
T6392 10370-10373 NN denotes p53
T6393 10374-10375 -LRB- denotes (
T6394 10375-10380 NNP denotes Chang
T6395 10381-10383 FW denotes et
T6396 10384-10387 FW denotes al.
T6397 10387-10388 , denotes ,
T6398 10389-10393 CD denotes 2001
T6399 10393-10394 -RRB- denotes )
T6400 10394-10395 . denotes .
T6401 10396-10400 RB denotes Also
T6402 10400-10401 , denotes ,
T6403 10402-10406 NNP denotes WWOX
T6404 10407-10415 VBZ denotes mediates
T6405 10416-10420 NN denotes cell
T6406 10421-10426 NN denotes death
T6407 10427-10442 RB denotes synergistically
T6408 10443-10447 IN denotes with
T6409 10448-10451 NN denotes p53
T6410 10451-10452 . denotes .
T6411 10453-10457 IN denotes Upon
T6412 10458-10466 NN denotes exposure
T6413 10467-10469 TO denotes to
T6414 10470-10479 NNS denotes chemicals
T6415 10480-10482 CC denotes or
T6416 10483-10496 JJ denotes environmental
T6417 10497-10503 NN denotes stress
T6418 10503-10504 , denotes ,
T6419 10505-10509 JJ denotes such
T6420 10510-10512 IN denotes as
T6421 10513-10515 NNP denotes UV
T6422 10516-10527 NN denotes irradiation
T6423 10528-10531 CC denotes and
T6424 10532-10548 JJ denotes chemotherapeutic
T6425 10549-10554 NNS denotes drugs
T6426 10554-10555 , denotes ,
T6427 10556-10560 NNP denotes WWOX
T6428 10561-10570 VBZ denotes undergoes
T6429 10571-10586 NN denotes phosphorylation
T6430 10587-10589 IN denotes in
T6431 10590-10595 NNP denotes Tyr33
T6432 10596-10599 CC denotes and
T6433 10600-10608 RB denotes probably
T6434 10609-10615 NNS denotes others
T6435 10616-10621 NNS denotes sites
T6436 10621-10622 , denotes ,
T6437 10623-10631 VBN denotes followed
T6438 10632-10634 IN denotes by
T6439 10635-10645 VBG denotes relocating
T6440 10646-10648 TO denotes to
T6441 10649-10661 NN denotes mitochondria
T6442 10662-10664 CC denotes or
T6443 10665-10671 NN denotes nuclei
T6444 10672-10675 IN denotes for
T6445 10676-10684 VBG denotes inducing
T6446 10685-10694 NN denotes apoptosis
T6447 10695-10696 -LRB- denotes (
T6448 10696-10701 NNP denotes Chang
T6449 10702-10704 FW denotes et
T6450 10705-10708 FW denotes al.
T6451 10708-10709 , denotes ,
T6452 10710-10714 CD denotes 2007
T6453 10714-10715 , denotes ,
T6454 10716-10720 CD denotes 2010
T6455 10720-10721 -RRB- denotes )
T6456 10721-10722 . denotes .
T6457 10723-10727 NNP denotes WWOX
T6458 10728-10733 VBZ denotes binds
T6459 10734-10737 NNP denotes MEK
T6460 10738-10740 IN denotes in
T6461 10741-10747 NNP denotes Jurkat
T6462 10748-10749 NNP denotes T
T6463 10750-10755 NNS denotes cells
T6464 10756-10757 -LRB- denotes (
T6465 10757-10760 NNP denotes Lin
T6466 10761-10763 FW denotes et
T6467 10764-10767 FW denotes al.
T6468 10767-10768 , denotes ,
T6469 10769-10773 CD denotes 2011
T6470 10773-10774 -RRB- denotes )
T6471 10774-10775 . denotes .
T6472 10776-10783 NNP denotes Phorbol
T6473 10784-10793 NN denotes myristate
T6474 10794-10801 NN denotes acetate
T6475 10802-10803 -LRB- denotes (
T6476 10803-10806 NNP denotes PMA
T6477 10806-10807 -RRB- denotes )
T6478 10808-10819 VBZ denotes dissociates
T6479 10820-10823 DT denotes the
T6480 10824-10832 NNP denotes MEK/WWOX
T6481 10833-10840 NN denotes complex
T6482 10841-10844 CC denotes and
T6483 10845-10852 VBZ denotes induces
T6484 10853-10857 NNP denotes WWOX
T6485 10858-10860 TO denotes to
T6486 10861-10872 VB denotes translocate
T6487 10873-10875 TO denotes to
T6488 10876-10879 DT denotes the
T6489 10880-10892 NN denotes mitochondria
T6490 10893-10895 TO denotes to
T6491 10896-10902 VB denotes induce
T6492 10903-10912 NN denotes apoptosis
T6493 10912-10913 , denotes ,
T6494 10914-10921 IN denotes whereas
T6495 10922-10925 NNP denotes MEK
T6496 10926-10935 VBZ denotes relocates
T6497 10936-10938 TO denotes to
T6498 10939-10942 DT denotes the
T6499 10943-10948 JJ denotes lipid
T6500 10949-10953 NN denotes raft
T6501 10953-10954 . denotes .
T6502 10955-10965 NNP denotes Inhibition
T6503 10966-10968 IN denotes of
T6504 10969-10972 NNP denotes MEK
T6505 10973-10981 NN denotes activity
T6506 10982-10991 VBZ denotes increases
T6507 10992-11003 JJ denotes TMZ-induced
T6508 11004-11015 NN denotes suppression
T6509 11016-11018 IN denotes of
T6510 11019-11025 NN denotes cancer
T6511 11026-11030 NN denotes cell
T6512 11031-11037 NN denotes growth
T6513 11038-11039 -LRB- denotes (
T6514 11039-11043 NNP denotes Holt
T6515 11044-11046 FW denotes et
T6516 11047-11050 FW denotes al.
T6517 11050-11051 , denotes ,
T6518 11052-11056 CD denotes 2012
T6519 11056-11057 -RRB- denotes )
T6520 11057-11058 . denotes .
T6521 11059-11066 JJ denotes Ectopic
T6522 11067-11077 NN denotes expression
T6523 11078-11080 IN denotes of
T6524 11081-11085 NNP denotes WWOX
T6525 11086-11088 IN denotes in
T6526 11089-11093 NNP denotes A549
T6527 11094-11099 NNS denotes cells
T6528 11100-11107 VBZ denotes induces
T6529 11108-11120 JJ denotes procaspase-3
T6530 11121-11124 CC denotes and
T6531 11125-11137 JJ denotes procaspase-9
T6532 11138-11148 NN denotes activation
T6533 11149-11152 CC denotes and
T6534 11153-11160 VBZ denotes induces
T6535 11161-11171 NN denotes cytochrome
T6536 11172-11173 NNP denotes C
T6537 11174-11183 VBG denotes releasing
T6538 11184-11188 IN denotes from
T6539 11189-11192 DT denotes the
T6540 11193-11205 NN denotes mitochondria
T6541 11206-11207 -LRB- denotes (
T6542 11207-11212 NNP denotes Zhang
T6543 11213-11215 FW denotes et
T6544 11216-11219 FW denotes al.
T6545 11219-11220 , denotes ,
T6546 11221-11226 JJ denotes 2012a
T6547 11226-11227 -RRB- denotes )
T6548 11227-11228 . denotes .
T6549 11229-11239 NN denotes Complement
T6550 11240-11243 NN denotes C1q
T6551 11244-11251 VBZ denotes induces
T6552 11252-11259 JJ denotes ectopic
T6553 11260-11264 NNP denotes WWOX
T6554 11265-11280 NN denotes phosphorylation
T6555 11281-11283 IN denotes in
T6556 11284-11289 NNP denotes Try33
T6557 11290-11293 CC denotes and
T6558 11294-11299 VBZ denotes leads
T6559 11300-11302 TO denotes to
T6560 11303-11307 NN denotes cell
T6561 11308-11317 NN denotes apoptosis
T6562 11318-11331 RB denotes independently
T6563 11332-11334 IN denotes of
T6564 11335-11338 DT denotes the
T6565 11339-11348 JJ denotes classical
T6566 11349-11359 VBP denotes complement
T6567 11360-11370 NN denotes activation
T6568 11371-11378 NN denotes pathway
T6569 11379-11380 -LRB- denotes (
T6570 11380-11384 NNP denotes Hong
T6571 11385-11387 FW denotes et
T6572 11388-11391 FW denotes al.
T6573 11391-11392 , denotes ,
T6574 11393-11397 CD denotes 2009
T6575 11397-11398 -RRB- denotes )
T6576 11398-11399 . denotes .
T6577 11400-11401 DT denotes A
T6578 11402-11409 NN denotes portion
T6579 11410-11412 IN denotes of
T6580 11413-11417 NNP denotes WWOX
T6581 11418-11420 VBZ denotes is
T6582 11421-11429 VBN denotes anchored
T6583 11430-11432 IN denotes in
T6584 11433-11436 DT denotes the
T6585 11437-11458 JJ denotes membrane/cytoskeleton
T6586 11459-11463 NN denotes area
T6587 11464-11467 IN denotes via
T6588 11468-11475 JJ denotes binding
T6589 11476-11480 IN denotes with
T6590 11481-11494 NN denotes hyaluronidase
T6591 11495-11501 NN denotes Hyal-2
T6592 11502-11503 -LRB- denotes (
T6593 11503-11506 NNP denotes Hsu
T6594 11507-11509 FW denotes et
T6595 11510-11513 FW denotes al.
T6596 11513-11514 , denotes ,
T6597 11515-11519 CD denotes 2009
T6598 11519-11520 -RRB- denotes )
T6599 11521-11524 CC denotes and
T6600 11525-11538 NNP denotes Phospho-Ezrin
T6601 11539-11540 -LRB- denotes (
T6602 11540-11543 NNP denotes Jin
T6603 11544-11546 FW denotes et
T6604 11547-11550 FW denotes al.
T6605 11550-11551 , denotes ,
T6606 11552-11556 CD denotes 2006
T6607 11556-11557 -RRB- denotes )
T6608 11557-11558 . denotes .
T6609 11559-11571 VBG denotes Transforming
T6610 11572-11578 NN denotes growth
T6611 11579-11585 NN denotes factor
T6612 11586-11588 CD denotes β1
T6613 11589-11594 NNS denotes binds
T6614 11595-11601 JJ denotes Hyal-2
T6615 11602-11604 IN denotes as
T6616 11605-11606 DT denotes a
T6617 11607-11614 NN denotes cognate
T6618 11615-11623 NN denotes receptor
T6619 11624-11626 TO denotes to
T6620 11627-11633 VB denotes signal
T6621 11634-11637 DT denotes the
T6622 11638-11647 NN denotes formation
T6623 11648-11650 IN denotes of
T6624 11651-11654 DT denotes the
T6625 11655-11664 NNP denotes WWOX/Hyal
T6626 11664-11666 CD denotes -2
T6627 11666-11667 CD denotes /
T6628 11667-11672 NNP denotes Smad4
T6629 11673-11680 NN denotes complex
T6630 11681-11683 TO denotes to
T6631 11684-11692 VB denotes relocate
T6632 11693-11695 TO denotes to
T6633 11696-11699 DT denotes the
T6634 11700-11707 NN denotes nucleus
T6635 11708-11711 IN denotes for
T6636 11712-11721 VBG denotes enhancing
T6637 11722-11725 DT denotes the
T6638 11726-11737 JJ denotes SMAD-driven
T6639 11738-11746 NN denotes promoter
T6640 11747-11755 NN denotes activity
T6641 11756-11757 -LRB- denotes (
T6642 11757-11760 NNP denotes Hsu
T6643 11761-11763 FW denotes et
T6644 11764-11767 FW denotes al.
T6645 11767-11768 , denotes ,
T6646 11769-11773 CD denotes 2009
T6647 11773-11774 -RRB- denotes )
T6648 11774-11775 . denotes .
T7155 11795-11804 VBN denotes Activated
T7156 11805-11808 NN denotes p53
T7157 11809-11817 NNS denotes mediates
T7158 11818-11827 NN denotes apoptosis
T7159 11827-11828 , denotes ,
T7160 11829-11833 NN denotes cell
T7161 11834-11839 NN denotes cycle
T7162 11840-11846 NN denotes arrest
T7163 11846-11847 , denotes ,
T7164 11848-11858 NN denotes senescence
T7165 11858-11859 , denotes ,
T7166 11860-11863 NNP denotes DNA
T7167 11864-11870 NN denotes repair
T7168 11870-11871 , denotes ,
T7169 11872-11874 CC denotes or
T7170 11875-11885 NN denotes metabolism
T7171 11886-11887 -LRB- denotes (
T7172 11887-11891 NNP denotes Lane
T7173 11892-11895 CC denotes and
T7174 11896-11902 NNP denotes Levine
T7175 11902-11903 , denotes ,
T7176 11904-11908 CD denotes 2010
T7177 11908-11909 -RRB- denotes )
T7178 11909-11910 . denotes .
T7179 11911-11914 DT denotes The
T7180 11915-11922 JJ denotes primary
T7181 11923-11933 NNS denotes structures
T7182 11934-11936 IN denotes of
T7183 11937-11940 NN denotes p53
T7184 11941-11944 CC denotes and
T7185 11945-11948 PRP$ denotes its
T7186 11949-11957 NNS denotes isoforms
T7187 11958-11961 VBP denotes are
T7188 11962-11970 VBN denotes depicted
T7189 11971-11972 -LRB- denotes (
T7190 11972-11978 NN denotes Figure
T7191 11979-11980 CD denotes 2
T7192 11980-11981 -RRB- denotes )
T7193 11981-11982 . denotes .
T7194 11983-11986 NN denotes p53
T7195 11987-11994 VBZ denotes induces
T7196 11995-11999 NN denotes cell
T7197 12000-12005 NN denotes cycle
T7198 12006-12012 NN denotes arrest
T7199 12013-12015 IN denotes by
T7200 12016-12031 VBG denotes transactivating
T7201 12032-12037 NNS denotes genes
T7202 12038-12042 JJ denotes such
T7203 12043-12045 IN denotes as
T7204 12046-12062 JJ denotes cyclin-dependent
T7205 12063-12069 NN denotes kinase
T7206 12070-12079 NN denotes inhibitor
T7207 12080-12083 CD denotes p21
T7208 12083-12084 , denotes ,
T7209 12085-12087 CC denotes or
T7210 12088-12096 NNP denotes microRNA
T7211 12097-12102 NNP denotes miR34
T7212 12102-12103 . denotes .
T7213 12104-12107 NN denotes p53
T7214 12108-12115 VBZ denotes induces
T7215 12116-12125 NN denotes apoptosis
T7216 12126-12128 IN denotes by
T7217 12129-12144 VBG denotes transactivating
T7218 12145-12157 JJ denotes proapoptotic
T7219 12158-12163 NNS denotes genes
T7220 12164-12168 JJ denotes such
T7221 12169-12171 IN denotes as
T7222 12172-12175 NNP denotes BAX
T7223 12175-12176 , denotes ,
T7224 12177-12181 NNP denotes PUMA
T7225 12181-12182 , denotes ,
T7226 12183-12189 NNP denotes SCOTIN
T7227 12189-12190 , denotes ,
T7228 12191-12194 CC denotes and
T7229 12195-12198 NNP denotes FAS
T7230 12198-12199 , denotes ,
T7231 12200-12203 CC denotes and
T7232 12204-12214 VBG denotes inhibiting
T7233 12215-12218 DT denotes the
T7234 12219-12232 JJ denotes antiapoptotic
T7235 12233-12237 NN denotes gene
T7236 12238-12243 NN denotes BCL-2
T7237 12244-12245 -LRB- denotes (
T7238 12245-12249 NNP denotes Lane
T7239 12250-12253 CC denotes and
T7240 12254-12260 NNP denotes Levine
T7241 12260-12261 , denotes ,
T7242 12262-12266 CD denotes 2010
T7243 12266-12267 -RRB- denotes )
T7244 12267-12268 . denotes .
T7245 12269-12272 NN denotes p53
T7246 12273-12281 VBZ denotes triggers
T7247 12282-12294 JJ denotes pro-survival
T7248 12295-12297 CC denotes or
T7249 12298-12302 NN denotes cell
T7250 12303-12308 NN denotes death
T7251 12309-12317 NN denotes response
T7252 12317-12318 , denotes ,
T7253 12319-12328 VBG denotes depending
T7254 12329-12333 IN denotes upon
T7255 12334-12338 NN denotes cell
T7256 12339-12344 NNS denotes types
T7257 12344-12345 , denotes ,
T7258 12346-12349 DT denotes the
T7259 12350-12359 NN denotes intensity
T7260 12360-12362 IN denotes of
T7261 12363-12366 DT denotes the
T7262 12367-12373 NN denotes stress
T7263 12374-12380 NN denotes signal
T7264 12380-12381 , denotes ,
T7265 12382-12385 CC denotes and
T7266 12386-12389 DT denotes the
T7267 12390-12396 NN denotes extent
T7268 12397-12399 IN denotes of
T7269 12400-12408 JJ denotes cellular
T7270 12409-12415 NN denotes damage
T7271 12416-12417 -LRB- denotes (
T7272 12417-12425 NNP denotes Menendez
T7273 12426-12428 FW denotes et
T7274 12429-12432 FW denotes al.
T7275 12432-12433 , denotes ,
T7276 12434-12438 CD denotes 2009
T7277 12438-12439 -RRB- denotes )
T7278 12439-12440 . denotes .
T7279 12441-12445 RB denotes Also
T7280 12445-12446 , denotes ,
T7281 12447-12450 NN denotes p53
T7282 12451-12456 VBZ denotes plays
T7283 12457-12458 DT denotes a
T7284 12459-12463 NN denotes role
T7285 12464-12466 IN denotes in
T7286 12467-12478 VBG denotes controlling
T7287 12479-12483 NN denotes cell
T7288 12484-12492 NN denotes motility
T7289 12493-12496 IN denotes via
T7290 12497-12507 VBG denotes regulating
T7291 12508-12511 DT denotes the
T7292 12512-12522 NN denotes expression
T7293 12523-12525 IN denotes of
T7294 12526-12532 JJ denotes smooth
T7295 12533-12539 NN denotes muscle
T7296 12540-12547 NN denotes α-actin
T7297 12548-12549 -LRB- denotes (
T7298 12549-12554 NNP denotes Comer
T7299 12555-12557 FW denotes et
T7300 12558-12561 FW denotes al.
T7301 12561-12562 , denotes ,
T7302 12563-12567 CD denotes 1998
T7303 12567-12568 -RRB- denotes )
T7304 12568-12569 , denotes ,
T7305 12570-12579 VBZ denotes collagens
T7306 12580-12584 NNP denotes IIα1
T7307 12585-12588 CC denotes and
T7308 12589-12593 NNP denotes VIα1
T7309 12594-12595 -LRB- denotes (
T7310 12595-12598 NNP denotes Sun
T7311 12599-12601 FW denotes et
T7312 12602-12605 FW denotes al.
T7313 12605-12606 , denotes ,
T7314 12607-12611 CD denotes 1999
T7315 12611-12612 -RRB- denotes )
T7316 12612-12613 , denotes ,
T7317 12614-12617 CC denotes and
T7318 12618-12622 JJ denotes many
T7319 12623-12629 NNS denotes others
T7320 12629-12630 . denotes .
T14525 12641-12644 NN denotes p53
T14526 12645-12648 CC denotes and
T14527 12649-12653 NNP denotes WWOX
T14528 12654-12656 IN denotes in
T14529 12657-12660 NNP denotes GBM
T14530 12661-12665 NN denotes cell
T14531 12666-12675 NN denotes apoptosis
T14532 12675-12676 . denotes .
T14533 12677-12678 -LRB- denotes (
T14534 12678-12679 NNP denotes A
T14535 12679-12680 -RRB- denotes )
T14536 12681-12692 JJ denotes Full-length
T14537 12693-12696 NN denotes p53
T14538 12697-12706 VBZ denotes possesses
T14539 12707-12710 CD denotes two
T14540 12711-12721 JJ denotes N-terminal
T14541 12722-12737 NN denotes transactivation
T14542 12738-12744 JJ denotes acidic
T14543 12745-12752 NNS denotes domains
T14544 12752-12753 , denotes ,
T14545 12754-12755 DT denotes a
T14546 12756-12768 JJ denotes proline-rich
T14547 12769-12775 NN denotes domain
T14548 12775-12776 , denotes ,
T14549 12777-12778 DT denotes a
T14550 12779-12786 JJ denotes central
T14551 12787-12798 JJ denotes DNA-binding
T14552 12799-12805 NN denotes region
T14553 12805-12806 , denotes ,
T14554 12807-12810 CC denotes and
T14555 12811-12812 DT denotes a
T14556 12813-12823 JJ denotes C-terminal
T14557 12824-12830 NN denotes domain
T14558 12830-12831 , denotes ,
T14559 12832-12842 VBG denotes containing
T14560 12843-12844 DT denotes a
T14561 12845-12852 JJ denotes nuclear
T14562 12853-12865 NN denotes localization
T14563 12866-12872 NN denotes signal
T14564 12872-12873 , denotes ,
T14565 12874-12876 DT denotes an
T14566 12877-12892 NN denotes oligomerization
T14567 12893-12899 NN denotes domain
T14568 12899-12900 , denotes ,
T14569 12901-12904 CC denotes and
T14570 12905-12906 DT denotes a
T14571 12907-12912 JJ denotes basic
T14572 12913-12919 NN denotes region
T14573 12919-12920 . denotes .
T14574 12921-12931 JJ denotes N-terminal
T14575 12932-12940 NN denotes deletion
T14576 12941-12948 NNS denotes mutants
T14577 12949-12951 IN denotes of
T14578 12952-12955 NN denotes p53
T14579 12956-12959 VBP denotes are
T14580 12960-12964 RB denotes also
T14581 12965-12970 VBN denotes shown
T14582 12970-12971 . denotes .
T14583 12972-12973 -LRB- denotes (
T14584 12973-12974 NNP denotes B
T14585 12974-12975 -RRB- denotes )
T14586 12976-12981 CD denotes Three
T14587 12982-12988 JJ denotes likely
T14588 12989-12998 NNS denotes scenarios
T14589 12999-13002 VBP denotes are
T14590 13003-13011 VBN denotes proposed
T14591 13012-13015 IN denotes for
T14592 13016-13020 NNP denotes WWOX
T14593 13021-13024 CC denotes and
T14594 13025-13028 NN denotes p53
T14595 13029-13031 TO denotes to
T14596 13032-13040 VB denotes regulate
T14597 13041-13044 NNP denotes GBM
T14598 13045-13049 NN denotes cell
T14599 13050-13055 NN denotes death
T14600 13055-13056 . denotes .
T14601 13057-13062 RB denotes First
T14602 13062-13063 , denotes ,
T14603 13064-13071 JJ denotes ectopic
T14604 13072-13076 NNP denotes WWOX
T14605 13077-13082 VBZ denotes fails
T14606 13083-13085 TO denotes to
T14607 13086-13092 VB denotes induce
T14608 13093-13102 NN denotes apoptosis
T14609 13103-13105 IN denotes of
T14610 13106-13109 NNP denotes GBM
T14611 13110-13115 NNS denotes cells
T14612 13116-13126 VBG denotes expressing
T14613 13127-13137 JJ denotes endogenous
T14614 13138-13142 JJ denotes wild
T14615 13143-13147 NN denotes type
T14616 13148-13151 NN denotes p53
T14617 13151-13152 . denotes .
T14618 13153-13155 PRP denotes It
T14619 13156-13163 VBZ denotes appears
T14620 13164-13168 IN denotes that
T14621 13169-13176 JJ denotes ectopic
T14622 13177-13181 NNP denotes WWOX
T14623 13182-13187 NNS denotes binds
T14624 13188-13191 CC denotes and
T14625 13192-13204 RB denotes functionally
T14626 13205-13216 NNS denotes antagonizes
T14627 13217-13220 NN denotes p53
T14628 13220-13221 , denotes ,
T14629 13222-13225 CC denotes and
T14630 13226-13230 DT denotes both
T14631 13231-13239 NNS denotes proteins
T14632 13240-13247 VBP denotes nullify
T14633 13248-13252 DT denotes each
T14634 13253-13258 JJ denotes other
T14635 13261-13269 NN denotes function
T14636 13270-13272 IN denotes in
T14637 13273-13281 VBG denotes inducing
T14638 13282-13291 NN denotes apoptosis
T14639 13291-13292 . denotes .
T14640 13293-13299 NNP denotes Second
T14641 13299-13300 , denotes ,
T14642 13301-13303 DT denotes no
T14643 13304-13312 JJ denotes physical
T14644 13313-13325 NNS denotes interactions
T14645 13326-13333 IN denotes between
T14646 13334-13340 JJ denotes mutant
T14647 13341-13344 NN denotes p53
T14648 13345-13353 NNS denotes proteins
T14649 13354-13357 CC denotes and
T14650 13358-13362 NNP denotes WWOX
T14651 13363-13366 VBP denotes are
T14652 13367-13375 VBN denotes expected
T14653 13376-13378 IN denotes in
T14654 13379-13382 NNP denotes GBM
T14655 13383-13388 NNS denotes cells
T14656 13388-13389 . denotes .
T14657 13390-13394 RB denotes Thus
T14658 13394-13395 , denotes ,
T14659 13396-13403 JJ denotes ectopic
T14660 13404-13408 NNP denotes WWOX
T14661 13409-13415 VB denotes induce
T14662 13416-13425 NN denotes apoptosis
T14663 13426-13428 IN denotes in
T14664 13429-13435 JJ denotes mutant
T14665 13436-13450 JJ denotes p53-expressing
T14666 13451-13456 NNS denotes cells
T14667 13456-13457 . denotes .
T14668 13458-13465 RB denotes Finally
T14669 13465-13466 , denotes ,
T14670 13467-13474 IN denotes whether
T14671 13475-13479 NNP denotes WWOX
T14672 13480-13485 VBZ denotes binds
T14673 13486-13489 NN denotes p53
T14674 13490-13498 NNS denotes isoforms
T14675 13499-13501 VBZ denotes is
T14676 13502-13509 JJ denotes unknown
T14677 13509-13510 . denotes .
T14678 13511-13515 RB denotes Also
T14679 13515-13516 , denotes ,
T14680 13517-13524 IN denotes whether
T14681 13525-13532 JJ denotes ectopic
T14682 13533-13537 NNP denotes WWOX
T14683 13538-13547 NN denotes induction
T14684 13548-13550 IN denotes of
T14685 13551-13560 NN denotes apoptosis
T14686 13561-13563 IN denotes in
T14687 13564-13567 NNP denotes GBM
T14688 13568-13573 NNS denotes cells
T14689 13574-13584 VBG denotes expressing
T14690 13585-13588 NN denotes p53
T14691 13589-13597 NNS denotes isoforms
T14692 13598-13605 VBZ denotes remains
T14693 13606-13608 TO denotes to
T14694 13609-13611 VB denotes be
T14695 13612-13623 VBN denotes established
T14696 13623-13624 . denotes .
T14697 13625-13628 NN denotes TAD
T14698 13628-13629 , denotes ,
T14699 13630-13645 NN denotes transactivation
T14700 13646-13652 NN denotes domain
T14701 13652-13653 : denotes ;
T14702 13654-13657 NNP denotes PrD
T14703 13657-13658 , denotes ,
T14704 13659-13666 NN denotes proline
T14705 13667-13673 NN denotes domain
T14706 13673-13674 : denotes ;
T14707 13675-13678 NNP denotes NLS
T14708 13678-13679 , denotes ,
T14709 13680-13687 JJ denotes nuclear
T14710 13688-13700 NN denotes localization
T14711 13701-13707 NN denotes signal
T14712 13707-13708 : denotes ;
T14713 13709-13711 NNP denotes OD
T14714 13711-13712 , denotes ,
T14715 13713-13728 NN denotes oligomerization
T14716 13729-13735 NN denotes domain
T14717 13735-13736 : denotes ;
T14718 13737-13739 NNP denotes BR
T14719 13739-13740 , denotes ,
T14720 13741-13746 JJ denotes basic
T14721 13747-13753 NN denotes region
T14722 13753-13754 . denotes .
T7989 13769-13771 IN denotes At
T7990 13772-13777 JJS denotes least
T7991 13778-13782 CD denotes nine
T7992 13783-13791 NNS denotes isoforms
T7993 13792-13794 IN denotes of
T7994 13795-13798 NN denotes p53
T7995 13799-13803 VBP denotes have
T7996 13804-13808 VBN denotes been
T7997 13809-13819 VBN denotes identified
T7998 13820-13823 JJ denotes due
T7999 13824-13826 TO denotes to
T8000 13827-13838 JJ denotes alternative
T8001 13839-13843 NNP denotes mRNA
T8002 13844-13852 NN denotes splicing
T8003 13852-13853 , denotes ,
T8004 13854-13862 JJ denotes multiple
T8005 13863-13867 NN denotes gene
T8006 13868-13877 NNS denotes promoters
T8007 13877-13878 , denotes ,
T8008 13879-13882 CC denotes and
T8009 13883-13894 JJ denotes alternative
T8010 13895-13905 NN denotes initiation
T8011 13906-13911 NNS denotes sites
T8012 13912-13914 IN denotes of
T8013 13915-13926 NN denotes translation
T8014 13927-13928 -LRB- denotes (
T8015 13928-13933 NNP denotes Ghosh
T8016 13934-13936 FW denotes et
T8017 13937-13940 FW denotes al.
T8018 13940-13941 , denotes ,
T8019 13942-13946 CD denotes 2004
T8020 13946-13947 : denotes ;
T8021 13948-13951 NNP denotes Ray
T8022 13952-13954 FW denotes et
T8023 13955-13958 FW denotes al.
T8024 13958-13959 , denotes ,
T8025 13960-13964 CD denotes 2006
T8026 13964-13965 : denotes ;
T8027 13966-13972 NN denotes Figure
T8028 13973-13974 CD denotes 2
T8029 13974-13975 -RRB- denotes )
T8030 13975-13976 . denotes .
T8031 13977-13979 IN denotes In
T8032 13980-13987 NNS denotes cancers
T8033 13987-13988 , denotes ,
T8034 13989-13997 JJ denotes aberrant
T8035 13998-14008 NN denotes expression
T8036 14009-14011 IN denotes of
T8037 14012-14015 NN denotes p53
T8038 14016-14024 NNS denotes isoforms
T8039 14025-14031 VBZ denotes occurs
T8040 14032-14042 RB denotes frequently
T8041 14043-14044 -LRB- denotes (
T8042 14044-14051 NNP denotes Bourdon
T8043 14052-14054 FW denotes et
T8044 14055-14058 FW denotes al.
T8045 14058-14059 , denotes ,
T8046 14060-14064 CD denotes 2005
T8047 14064-14065 : denotes ;
T8048 14066-14073 NNP denotes Bourdon
T8049 14073-14074 , denotes ,
T8050 14075-14079 CD denotes 2007
T8051 14079-14080 -RRB- denotes )
T8052 14080-14081 . denotes .
T8053 14082-14093 JJ denotes Full-length
T8054 14094-14097 NN denotes p53
T8055 14097-14098 , denotes ,
T8056 14099-14106 NNP denotes Δ133p53
T8057 14106-14107 , denotes ,
T8058 14108-14111 CC denotes and
T8059 14112-14116 CD denotes p53β
T8060 14117-14120 VBP denotes are
T8061 14121-14130 VBN denotes localized
T8062 14131-14137 RB denotes mainly
T8063 14138-14140 IN denotes in
T8064 14141-14144 DT denotes the
T8065 14145-14152 NN denotes nucleus
T8066 14152-14153 , denotes ,
T8067 14154-14157 CC denotes and
T8068 14158-14162 RB denotes only
T8069 14163-14166 JJ denotes few
T8070 14167-14169 IN denotes of
T8071 14170-14174 PRP denotes them
T8072 14175-14178 VBP denotes are
T8073 14179-14181 IN denotes in
T8074 14182-14191 NN denotes cytoplasm
T8075 14191-14192 . denotes .
T8076 14193-14197 CD denotes p53γ
T8077 14198-14201 CC denotes and
T8078 14202-14210 NNP denotes Δ133p53β
T8079 14211-14214 VBP denotes are
T8080 14215-14224 VBN denotes localized
T8081 14225-14227 IN denotes in
T8082 14228-14231 DT denotes the
T8083 14232-14239 NN denotes nucleus
T8084 14240-14243 CC denotes and
T8085 14244-14253 NN denotes cytoplasm
T8086 14253-14254 . denotes .
T8087 14255-14263 NNP denotes Δ133p53γ
T8088 14264-14266 VBZ denotes is
T8089 14267-14276 VBN denotes localized
T8090 14277-14279 IN denotes in
T8091 14280-14283 DT denotes the
T8092 14284-14293 NN denotes cytoplasm
T8093 14294-14295 -LRB- denotes (
T8094 14295-14302 NNP denotes Bourdon
T8095 14303-14305 FW denotes et
T8096 14306-14309 FW denotes al.
T8097 14309-14310 , denotes ,
T8098 14311-14315 CD denotes 2005
T8099 14315-14316 -RRB- denotes )
T8100 14316-14317 . denotes .
T8101 14318-14333 NN denotes Co-transfection
T8102 14334-14336 IN denotes of
T8103 14337-14340 NN denotes p53
T8104 14341-14344 CC denotes and
T8105 14345-14349 JJ denotes p53β
T8106 14350-14359 NNS denotes increases
T8107 14360-14372 JJ denotes p53-mediated
T8108 14373-14382 NN denotes apoptosis
T8109 14382-14383 , denotes ,
T8110 14384-14391 IN denotes whereas
T8111 14392-14405 NN denotes co-expression
T8112 14406-14408 IN denotes of
T8113 14409-14412 NN denotes p53
T8114 14413-14417 IN denotes with
T8115 14418-14425 JJ denotes Δ133p53
T8116 14426-14436 NNS denotes suppresses
T8117 14437-14449 JJ denotes p53-mediated
T8118 14450-14459 NN denotes apoptosis
T8119 14460-14461 -LRB- denotes (
T8120 14461-14468 NNP denotes Bourdon
T8121 14469-14471 FW denotes et
T8122 14472-14475 FW denotes al.
T8123 14475-14476 , denotes ,
T8124 14477-14481 CD denotes 2005
T8125 14481-14482 -RRB- denotes )
T8126 14482-14483 . denotes .
T8127 14484-14491 JJ denotes Δ133p53
T8128 14492-14506 RB denotes differentially
T8129 14507-14516 VBZ denotes regulates
T8130 14517-14521 NN denotes gene
T8131 14522-14532 NN denotes expression
T8132 14533-14535 IN denotes in
T8133 14536-14549 JJ denotes p53-dependent
T8134 14550-14553 CC denotes and
T8135 14554-14555 : denotes -
T8136 14555-14566 JJ denotes independent
T8137 14567-14574 NNS denotes manners
T8138 14575-14576 -LRB- denotes (
T8139 14576-14583 NNP denotes Aoubala
T8140 14584-14586 FW denotes et
T8141 14587-14590 FW denotes al.
T8142 14590-14591 , denotes ,
T8143 14592-14596 CD denotes 2011
T8144 14596-14597 -RRB- denotes )
T8145 14597-14598 . denotes .
T8146 14599-14612 NN denotes Co-expression
T8147 14613-14615 IN denotes of
T8148 14616-14624 NNP denotes Δ133p53β
T8149 14625-14627 CC denotes or
T8150 14628-14636 NNP denotes Δ133p53γ
T8151 14637-14641 IN denotes with
T8152 14642-14645 NN denotes p53
T8153 14646-14650 VBZ denotes does
T8154 14651-14654 RB denotes not
T8155 14655-14661 VB denotes affect
T8156 14662-14665 NN denotes p53
T8157 14666-14681 JJ denotes transcriptional
T8158 14682-14690 NN denotes activity
T8159 14691-14693 IN denotes on
T8160 14694-14697 CD denotes p21
T8161 14698-14701 CC denotes and
T8162 14702-14705 NNP denotes Bax
T8163 14706-14715 NNS denotes promoters
T8164 14715-14716 , denotes ,
T8165 14717-14719 RB denotes as
T8166 14720-14724 RB denotes well
T8167 14725-14727 IN denotes as
T8168 14728-14737 NN denotes apoptosis
T8169 14737-14738 . denotes .
T9180 14773-14776 NN denotes p53
T9181 14777-14784 NNS denotes mutants
T9182 14785-14788 VBP denotes are
T9183 14789-14799 VBN denotes considered
T9184 14800-14802 IN denotes as
T9185 14803-14814 JJ denotes unfavorable
T9186 14815-14822 NNS denotes factors
T9187 14823-14826 IN denotes for
T9188 14827-14830 DT denotes the
T9189 14831-14844 NN denotes effectiveness
T9190 14845-14847 IN denotes in
T9191 14848-14860 JJ denotes radiotherapy
T9192 14861-14864 CC denotes and
T9193 14865-14868 NNP denotes TMZ
T9194 14869-14878 NN denotes treatment
T9195 14879-14881 IN denotes in
T9196 14882-14888 NN denotes glioma
T9197 14889-14894 NNS denotes cells
T9198 14895-14896 -LRB- denotes (
T9199 14896-14903 NNP denotes Gjerset
T9200 14904-14906 FW denotes et
T9201 14907-14910 FW denotes al.
T9202 14910-14911 , denotes ,
T9203 14912-14916 CD denotes 1995
T9204 14916-14917 : denotes ;
T9205 14918-14924 NNP denotes Hirose
T9206 14925-14927 FW denotes et
T9207 14928-14931 FW denotes al.
T9208 14931-14932 , denotes ,
T9209 14933-14937 CD denotes 2001
T9210 14937-14938 : denotes ;
T9211 14939-14948 NNP denotes Squatrito
T9212 14949-14951 FW denotes et
T9213 14952-14955 FW denotes al.
T9214 14955-14956 , denotes ,
T9215 14957-14961 CD denotes 2010
T9216 14961-14962 : denotes ;
T9217 14963-14969 NNP denotes Blough
T9218 14970-14972 FW denotes et
T9219 14973-14976 FW denotes al.
T9220 14976-14977 , denotes ,
T9221 14978-14982 CD denotes 2011
T9222 14982-14983 -RRB- denotes )
T9223 14983-14984 . denotes .
T9224 14985-14989 NN denotes Loss
T9225 14990-14992 IN denotes of
T9226 14993-15003 JJ denotes functional
T9227 15004-15007 NN denotes p53
T9228 15008-15015 VBZ denotes confers
T9229 15016-15027 NN denotes sensitivity
T9230 15028-15030 TO denotes to
T9231 15031-15034 NNP denotes TMZ
T9232 15035-15037 IN denotes in
T9233 15038-15044 NN denotes glioma
T9234 15045-15050 NNS denotes cells
T9235 15050-15051 , denotes ,
T9236 15052-15059 IN denotes whereas
T9237 15060-15064 JJ denotes wild
T9238 15065-15069 NN denotes type
T9239 15070-15073 NN denotes p53
T9240 15074-15083 VBZ denotes increases
T9241 15084-15087 DT denotes the
T9242 15088-15091 NNP denotes TMZ
T9243 15092-15102 NN denotes resistance
T9244 15103-15104 -LRB- denotes (
T9245 15104-15110 JJ denotes Blough
T9246 15111-15113 FW denotes et
T9247 15114-15117 FW denotes al.
T9248 15117-15118 , denotes ,
T9249 15119-15123 CD denotes 2011
T9250 15123-15124 -RRB- denotes )
T9251 15124-15125 . denotes .
T9252 15126-15129 NN denotes p53
T9253 15130-15137 NNS denotes mutants
T9254 15138-15144 VB denotes reduce
T9255 15145-15148 NNP denotes TMZ
T9256 15149-15160 NN denotes sensitivity
T9257 15161-15163 IN denotes in
T9258 15164-15171 NNS denotes gliomas
T9259 15172-15173 -LRB- denotes (
T9260 15173-15179 JJ denotes Blough
T9261 15180-15182 FW denotes et
T9262 15183-15186 FW denotes al.
T9263 15186-15187 , denotes ,
T9264 15188-15192 CD denotes 2011
T9265 15192-15193 -RRB- denotes )
T9266 15193-15194 . denotes .
T9267 15195-15202 VBN denotes Altered
T9268 15203-15207 NNP denotes WWOX
T9269 15208-15218 NN denotes expression
T9270 15219-15221 VBZ denotes is
T9271 15222-15227 VBN denotes shown
T9272 15228-15230 IN denotes in
T9273 15231-15235 NNS denotes GBMs
T9274 15235-15236 , denotes ,
T9275 15237-15239 IN denotes in
T9276 15240-15245 WDT denotes which
T9277 15246-15260 NN denotes downregulation
T9278 15261-15263 IN denotes of
T9279 15264-15268 NNP denotes WWOX
T9280 15269-15271 VBZ denotes is
T9281 15272-15282 VBN denotes associated
T9282 15283-15287 IN denotes with
T9283 15288-15292 NN denotes loss
T9284 15293-15295 IN denotes of
T9285 15296-15310 NN denotes heterozygosity
T9286 15311-15314 CC denotes and
T9287 15315-15323 NN denotes promoter
T9288 15324-15335 NN denotes methylation
T9289 15336-15337 -LRB- denotes (
T9290 15337-15342 NNP denotes Kosla
T9291 15343-15345 FW denotes et
T9292 15346-15349 FW denotes al.
T9293 15349-15350 , denotes ,
T9294 15351-15355 CD denotes 2011
T9295 15355-15356 -RRB- denotes )
T9296 15356-15357 . denotes .
T9297 15358-15366 RB denotes Recently
T9298 15366-15367 , denotes ,
T9299 15368-15370 PRP denotes we
T9300 15371-15383 VBD denotes demonstrated
T9301 15384-15388 IN denotes that
T9302 15389-15402 VBN denotes overexpressed
T9303 15403-15407 NNP denotes WWOX
T9304 15408-15415 VBZ denotes induces
T9305 15416-15425 NN denotes apoptosis
T9306 15426-15428 IN denotes of
T9307 15429-15441 NN denotes glioblastoma
T9308 15442-15449 NN denotes U373-MG
T9309 15450-15455 NNS denotes cells
T9310 15456-15465 VBG denotes harboring
T9311 15466-15472 JJ denotes mutant
T9312 15473-15476 NN denotes p53
T9313 15477-15479 IN denotes by
T9314 15480-15487 VBG denotes causing
T9315 15488-15498 JJ denotes hypoploidy
T9316 15499-15502 CC denotes and
T9317 15503-15506 NNP denotes DNA
T9318 15507-15520 NN denotes fragmentation
T9319 15521-15522 -LRB- denotes (
T9320 15522-15528 NNP denotes Chiang
T9321 15529-15531 FW denotes et
T9322 15532-15535 FW denotes al.
T9323 15535-15536 , denotes ,
T9324 15537-15541 CD denotes 2012
T9325 15541-15542 -RRB- denotes )
T9326 15542-15543 . denotes .
T9327 15544-15551 RB denotes However
T9328 15551-15552 , denotes ,
T9329 15553-15560 JJ denotes ectopic
T9330 15561-15565 NNP denotes WWOX
T9331 15566-15569 VBZ denotes has
T9332 15570-15572 DT denotes no
T9333 15573-15579 NN denotes effect
T9334 15580-15584 IN denotes with
T9335 15585-15591 JJ denotes U87-MG
T9336 15592-15602 VBG denotes expressing
T9337 15603-15607 JJ denotes wild
T9338 15608-15612 NN denotes type
T9339 15613-15616 NN denotes p53
T9340 15616-15617 . denotes .
T9341 15618-15624 IN denotes Unlike
T9342 15625-15628 NNP denotes TMZ
T9343 15628-15629 , denotes ,
T9344 15630-15634 NNP denotes WWOX
T9345 15635-15642 VBZ denotes induces
T9346 15643-15652 NN denotes apoptosis
T9347 15653-15655 IN denotes of
T9348 15656-15663 NN denotes U373-MG
T9349 15664-15669 NNS denotes cells
T9350 15670-15673 IN denotes via
T9351 15674-15675 DT denotes a
T9352 15676-15700 JJ denotes mitochondria-independent
T9353 15701-15704 CC denotes and
T9354 15705-15726 JJ denotes caspase-3-independent
T9355 15727-15734 NN denotes pathway
T9356 15735-15736 -LRB- denotes (
T9357 15736-15742 NNP denotes Chiang
T9358 15743-15745 FW denotes et
T9359 15746-15749 FW denotes al.
T9360 15749-15750 , denotes ,
T9361 15751-15755 CD denotes 2012
T9362 15755-15756 -RRB- denotes )
T9363 15756-15757 . denotes .
T9364 15758-15763 IN denotes While
T9365 15764-15767 DT denotes the
T9366 15768-15778 VBG denotes underlying
T9367 15779-15789 NNS denotes mechanisms
T9368 15790-15793 VBP denotes are
T9369 15794-15801 JJ denotes unknown
T9370 15801-15802 , denotes ,
T9371 15803-15805 PRP denotes it
T9372 15806-15808 VBZ denotes is
T9373 15809-15819 JJ denotes reasonable
T9374 15820-15822 TO denotes to
T9375 15823-15829 VB denotes assume
T9376 15830-15834 IN denotes that
T9377 15835-15838 DT denotes the
T9378 15839-15847 NN denotes survival
T9379 15848-15850 IN denotes of
T9380 15851-15856 JJ denotes human
T9381 15857-15869 NN denotes glioblastoma
T9382 15870-15875 NNS denotes cells
T9383 15876-15883 VBZ denotes depends
T9384 15884-15888 IN denotes upon
T9385 15889-15901 NNS denotes interactions
T9386 15902-15909 IN denotes between
T9387 15910-15913 DT denotes the
T9388 15914-15930 NN denotes gain-of-function
T9389 15931-15933 IN denotes of
T9390 15934-15937 NN denotes p53
T9391 15938-15945 NNS denotes mutants
T9392 15946-15949 CC denotes and
T9393 15950-15954 NNP denotes WWOX
T9394 15954-15955 . denotes .
T9395 15956-15965 VBN denotes Activated
T9396 15966-15970 NNP denotes WWOX
T9397 15971-15976 VBZ denotes binds
T9398 15977-15981 JJ denotes wild
T9399 15982-15986 NN denotes type
T9400 15987-15990 NN denotes p53
T9401 15991-15995 IN denotes with
T9402 15996-16001 NNP denotes Ser46
T9403 16002-16017 NN denotes phosphorylation
T9404 16018-16019 -LRB- denotes (
T9405 16019-16024 NNP denotes Chang
T9406 16025-16027 FW denotes et
T9407 16028-16031 FW denotes al.
T9408 16031-16032 , denotes ,
T9409 16033-16038 JJ denotes 2005b
T9410 16038-16039 -RRB- denotes )
T9411 16039-16040 . denotes .
T9412 16041-16043 NNP denotes UV
T9413 16044-16055 NN denotes irradiation
T9414 16056-16064 VBZ denotes enhances
T9415 16065-16068 DT denotes the
T9416 16069-16076 JJ denotes binding
T9417 16077-16089 NNS denotes interactions
T9418 16089-16090 . denotes .
T9419 16091-16098 IN denotes Despite
T9420 16099-16102 DT denotes the
T9421 16103-16111 NN denotes presence
T9422 16112-16114 IN denotes of
T9423 16115-16120 NNP denotes Ser46
T9424 16121-16123 IN denotes in
T9425 16124-16130 NNP denotes Δ40p53
T9426 16130-16131 , denotes ,
T9427 16132-16139 JJ denotes binding
T9428 16140-16142 IN denotes of
T9429 16143-16147 DT denotes this
T9430 16148-16155 NN denotes protein
T9431 16156-16160 IN denotes with
T9432 16161-16165 NNP denotes WWOX
T9433 16166-16173 VBZ denotes remains
T9434 16174-16176 TO denotes to
T9435 16177-16179 VB denotes be
T9436 16180-16190 VBN denotes determined
T9437 16190-16191 . denotes .
T9438 16192-16194 PRP denotes We
T9439 16195-16204 VBP denotes postulate
T9440 16205-16209 IN denotes that
T9441 16210-16212 IN denotes in
T9442 16213-16216 NNP denotes GBM
T9443 16217-16222 NNS denotes cells
T9444 16222-16223 , denotes ,
T9445 16224-16228 DT denotes both
T9446 16229-16233 JJ denotes wild
T9447 16234-16238 NN denotes type
T9448 16239-16242 NN denotes p53
T9449 16243-16246 CC denotes and
T9450 16247-16254 JJ denotes ectopic
T9451 16255-16259 NNP denotes WWOX
T9452 16260-16268 NNS denotes proteins
T9453 16269-16275 VBP denotes appear
T9454 16276-16278 TO denotes to
T9455 16279-16283 VB denotes have
T9456 16284-16285 DT denotes a
T9457 16286-16296 JJ denotes functional
T9458 16297-16307 NN denotes antagonism
T9459 16307-16308 , denotes ,
T9460 16309-16316 RB denotes thereby
T9461 16317-16327 VBG denotes nullifying
T9462 16328-16332 DT denotes each
T9463 16333-16338 JJ denotes other
T9464 16341-16349 NN denotes function
T9465 16350-16352 IN denotes in
T9466 16353-16361 VBG denotes inducing
T9467 16362-16371 NN denotes apoptosis
T9468 16372-16373 -LRB- denotes (
T9469 16373-16379 NN denotes Figure
T9470 16380-16381 CD denotes 2
T9471 16381-16382 -RRB- denotes )
T9472 16382-16383 . denotes .
T9473 16384-16390 JJ denotes Mutant
T9474 16391-16394 NN denotes p53
T9475 16395-16403 NNS denotes proteins
T9476 16404-16407 MD denotes can
T9477 16407-16410 RB denotes not
T9478 16411-16415 NN denotes bind
T9479 16416-16423 JJ denotes ectopic
T9480 16424-16428 NNP denotes WWOX
T9481 16429-16431 IN denotes in
T9482 16432-16435 NNP denotes GBM
T9483 16436-16441 NNS denotes cells
T9484 16441-16442 , denotes ,
T9485 16443-16446 CC denotes and
T9486 16447-16451 NNP denotes WWOX
T9487 16452-16454 VBZ denotes is
T9488 16455-16459 JJ denotes able
T9489 16460-16462 TO denotes to
T9490 16463-16469 VB denotes induce
T9491 16470-16479 NN denotes apoptosis
T9492 16479-16480 . denotes .
T9493 16481-16488 IN denotes Whether
T9494 16489-16493 NNP denotes WWOX
T9495 16494-16500 VBZ denotes causes
T9496 16501-16510 NN denotes apoptosis
T9497 16511-16513 IN denotes in
T9498 16514-16517 NNP denotes GBM
T9499 16518-16528 VBG denotes expressing
T9500 16529-16532 NN denotes p53
T9501 16533-16541 NNS denotes isoforms
T9502 16542-16544 VBZ denotes is
T9503 16545-16552 JJ denotes unknown
T9504 16553-16556 CC denotes and
T9505 16557-16564 VBZ denotes remains
T9506 16565-16567 TO denotes to
T9507 16568-16570 VB denotes be
T9508 16571-16582 VBN denotes established
T9509 16582-16583 . denotes .
T9985 16598-16605 IN denotes Whether
T9986 16606-16610 NNP denotes WWOX
T9987 16611-16618 VBZ denotes affects
T9988 16619-16622 NNP denotes TMZ
T9989 16623-16634 NN denotes sensitivity
T9990 16635-16638 VBZ denotes has
T9991 16639-16644 RB denotes never
T9992 16645-16649 VBN denotes been
T9993 16650-16660 VBN denotes determined
T9994 16660-16661 . denotes .
T9995 16662-16669 VBG denotes Binding
T9996 16670-16678 NNS denotes proteins
T9997 16679-16682 IN denotes for
T9998 16683-16687 NNP denotes WWOX
T9999 16688-16694 CC denotes and/or
T10000 16695-16698 NN denotes p53
T10001 16699-16702 VBP denotes are
T10002 16703-16709 JJ denotes likely
T10003 16710-16712 TO denotes to
T10004 16713-16719 VB denotes affect
T10005 16720-16729 NN denotes apoptosis
T10006 16730-16733 CC denotes and
T10007 16734-16737 NNP denotes TMZ
T10008 16738-16749 NN denotes sensitivity
T10009 16750-16752 IN denotes in
T10010 16753-16756 NNP denotes GBM
T10011 16757-16762 NNS denotes cells
T10012 16762-16763 . denotes .
T10013 16764-16768 NNP denotes WWOX
T10014 16769-16774 VBZ denotes binds
T10015 16775-16778 NNP denotes MEK
T10016 16778-16779 , denotes ,
T10017 16780-16783 CC denotes and
T10018 16784-16788 IN denotes that
T10019 16789-16792 NNP denotes PMA
T10020 16793-16804 VBZ denotes dissociates
T10021 16805-16809 DT denotes this
T10022 16810-16817 NN denotes complex
T10023 16818-16821 IN denotes for
T10024 16822-16829 VBG denotes causing
T11245 16830-16839 NN denotes apoptosis
T11246 16840-16842 IN denotes of
T11247 16843-16844 NNP denotes T
T11248 16845-16853 NN denotes leukemia
T11249 16854-16859 NNS denotes cells
T11250 16860-16861 -LRB- denotes (
T11251 16861-16864 NNP denotes Lin
T11252 16865-16867 FW denotes et
T11253 16868-16871 FW denotes al.
T11254 16871-16872 , denotes ,
T11255 16873-16877 CD denotes 2011
T11256 16877-16878 -RRB- denotes )
T11257 16878-16879 . denotes .
T11258 16880-16884 RB denotes Thus
T11259 16884-16885 , denotes ,
T11213 16886-16897 JJ denotes appropriate
T11214 16898-16907 NNS denotes chemicals
T11215 16907-16908 , denotes ,
T11216 16909-16914 WDT denotes which
T11217 16915-16920 VBP denotes break
T11218 16921-16926 RP denotes apart
T11219 16927-16930 DT denotes the
T11220 16931-16939 NNP denotes WWOX/MEK
T11221 16940-16947 NN denotes complex
T11222 16947-16948 , denotes ,
T11223 16949-16952 VBP denotes are
T11224 16953-16961 VBN denotes expected
T11225 16962-16964 TO denotes to
T11226 16965-16970 VB denotes cause
T11227 16971-16974 NNP denotes GBM
T11228 16975-16979 NN denotes cell
T11229 16980-16985 NN denotes death
T11230 16985-16986 . denotes .
T11231 16987-16998 JJ denotes Preliminary
T11232 16999-17006 NNS denotes studies
T11233 17007-17011 IN denotes from
T11234 17012-17015 PRP$ denotes our
T11235 17016-17025 NN denotes screening
T11236 17026-17028 IN denotes of
T11237 17029-17038 NNS denotes chemicals
T11238 17039-17043 VBP denotes have
T11239 17044-17052 VBN denotes selected
T11240 17053-17060 JJ denotes certain
T11241 17061-17066 JJ denotes small
T11242 17067-17076 NNS denotes molecules
T11243 17077-17081 WDT denotes that
T11244 17082-17088 VBP denotes induce
T11599 17089-17098 NN denotes apoptosis
T11600 17099-17101 IN denotes of
T11601 17102-17106 JJ denotes many
T11602 17107-17112 NNS denotes types
T11603 17113-17115 IN denotes of
T11604 17116-17122 NN denotes cancer
T11605 17123-17128 NNS denotes cells
T11606 17129-17130 -LRB- denotes (
T11607 17130-17132 NNP denotes Lu
T11608 17133-17135 FW denotes et
T11609 17136-17139 FW denotes al.
T11610 17139-17140 , denotes ,
T11611 17141-17152 JJ denotes unpublished
T11612 17152-17153 -RRB- denotes )
T11613 17153-17154 . denotes .
T11614 17155-17161 RB denotes Indeed
T11615 17161-17162 , denotes ,
T11616 17163-17171 JJ denotes specific
T11617 17172-17182 NN denotes inhibition
T11618 17183-17185 IN denotes of
T11619 17186-17189 NNP denotes MEK
T11620 17190-17192 IN denotes by
T11621 17193-17204 NN denotes selumetinib
T11622 17205-17213 VBZ denotes enhances
T11623 17214-17225 JJ denotes TMZ-induced
T11624 17226-17232 NN denotes cancer
T11625 17233-17237 NN denotes cell
T11626 17238-17243 NN denotes death
T11627 17244-17246 IN denotes in
T11628 17247-17251 NN denotes vivo
T11629 17252-17253 -LRB- denotes (
T11630 17253-17257 NNP denotes Holt
T11631 17258-17260 FW denotes et
T11632 17261-17264 FW denotes al.
T11633 17264-17265 , denotes ,
T11634 17266-17270 CD denotes 2012
T11635 17270-17271 -RRB- denotes )
T11636 17271-17272 . denotes .
T11637 17273-17278 NNP denotes Serum
T11638 17279-17286 NNS denotes factors
T11639 17287-17290 MD denotes can
T11640 17291-17293 VB denotes be
T11641 17294-17302 VBN denotes utilized
T11642 17303-17306 IN denotes for
T11643 17307-17315 VBG denotes blocking
T11644 17316-17322 NN denotes cancer
T11645 17323-17329 NN denotes growth
T11646 17329-17330 . denotes .
T11647 17331-17334 IN denotes For
T11648 17335-17342 NN denotes example
T11649 17342-17343 , denotes ,
T11650 17344-17349 NN denotes serum
T11651 17350-17360 VBP denotes complement
T11652 17361-17364 JJ denotes C1q
T11653 17365-17372 VBZ denotes induces
T11654 17373-17382 NN denotes apoptosis
T11655 17383-17385 IN denotes of
T11656 17386-17394 NN denotes prostate
T11657 17395-17401 NN denotes cancer
T11658 17402-17405 CC denotes and
T11659 17406-17420 NNS denotes neuroblastomas
T11660 17421-17426 NNS denotes cells
T11661 17427-17434 IN denotes without
T11662 17435-17448 NN denotes participation
T11663 17449-17451 IN denotes of
T11664 17452-17462 JJ denotes downstream
T11665 17463-17471 NNS denotes proteins
T11666 17472-17474 IN denotes in
T11667 17475-17478 DT denotes the
T11668 17479-17488 JJ denotes classical
T11669 17489-17499 NN denotes activation
T11670 17500-17507 NN denotes pathway
T11671 17508-17509 -LRB- denotes (
T11672 17509-17513 NNP denotes Hong
T11673 17514-17516 FW denotes et
T11674 17517-17520 FW denotes al.
T11675 17520-17521 , denotes ,
T11676 17522-17526 CD denotes 2009
T11677 17526-17527 -RRB- denotes )
T11678 17527-17528 . denotes .
T11679 17529-17531 IN denotes In
T11680 17532-17536 DT denotes this
T11681 17537-17542 NN denotes event
T11682 17542-17543 , denotes ,
T11683 17544-17551 JJ denotes ectopic
T11684 17552-17556 NNP denotes WWOX
T11685 17557-17559 VBZ denotes is
T11686 17560-17569 VBN denotes activated
T11687 17570-17573 IN denotes for
T11688 17574-17582 VBG denotes inducing
T11689 17583-17592 NN denotes apoptosis
T11690 17592-17593 . denotes .
T11691 17594-17601 NN denotes Failure
T11692 17602-17604 IN denotes of
T11693 17605-17612 JJ denotes ectopic
T11694 17613-17617 NNP denotes WWOX
T11695 17618-17620 IN denotes in
T11696 17621-17629 VBG denotes inducing
T11697 17630-17639 NN denotes apoptosis
T11698 17640-17642 IN denotes of
T11699 17643-17649 NN denotes glioma
T11700 17650-17655 NNS denotes cells
T11701 17656-17666 VBG denotes possessing
T11702 17667-17671 JJ denotes wild
T11703 17672-17676 NN denotes type
T11704 17677-17680 NN denotes p53
T11705 17681-17683 VBZ denotes is
T11706 17684-17691 JJ denotes unusual
T11707 17692-17693 -LRB- denotes (
T11708 17693-17699 NNP denotes Chiang
T11709 17700-17702 FW denotes et
T11710 17703-17706 FW denotes al.
T11711 17706-17707 , denotes ,
T11712 17708-17712 CD denotes 2012
T11713 17712-17713 -RRB- denotes )
T11714 17713-17714 . denotes .
T11715 17715-17717 IN denotes In
T11716 17718-17722 JJS denotes most
T11717 17723-17728 NNS denotes cases
T11718 17728-17729 , denotes ,
T11719 17730-17732 PRP denotes we
T11720 17733-17737 VBP denotes have
T11721 17738-17743 VBN denotes shown
T11722 17744-17748 IN denotes that
T11723 17749-17752 NN denotes p53
T11724 17753-17765 RB denotes functionally
T11725 17766-17775 VBZ denotes interacts
T11726 17776-17780 IN denotes with
T11727 17781-17785 NNP denotes WWOX
T11728 17785-17786 , denotes ,
T11729 17787-17790 CC denotes and
T11730 17791-17795 DT denotes both
T11731 17796-17804 NNS denotes proteins
T11732 17805-17811 VBP denotes induce
T11733 17812-17821 NN denotes apoptosis
T11734 17822-17824 IN denotes in
T11735 17825-17826 DT denotes a
T11736 17827-17838 JJ denotes synergistic
T11737 17839-17845 NN denotes manner
T11738 17846-17847 -LRB- denotes (
T11739 17847-17852 NNP denotes Chang
T11740 17853-17855 FW denotes et
T11741 17856-17859 FW denotes al.
T11742 17859-17860 , denotes ,
T11743 17861-17865 CD denotes 2001
T11744 17865-17866 , denotes ,
T11745 17867-17871 CD denotes 2003
T11746 17871-17872 , denotes ,
T11747 17873-17878 CD denotes 2005a
T11748 17878-17879 , denotes ,
T11749 17879-17880 NN denotes b
T11750 17880-17881 , denotes ,
T11751 17882-17886 CD denotes 2007
T11752 17886-17887 , denotes ,
T11753 17888-17892 CD denotes 2010
T11754 17892-17893 , denotes ,
T11755 17894-17898 CD denotes 2012
T11756 17898-17899 : denotes ;
T11757 17900-17902 NNP denotes Su
T11758 17903-17905 FW denotes et
T11759 17906-17909 FW denotes al.
T11760 17909-17910 , denotes ,
T11761 17911-17915 CD denotes 2012
T11762 17915-17916 -RRB- denotes )
T11763 17916-17917 . denotes .
T11764 17918-17919 DT denotes A
T11765 17920-17926 JJ denotes likely
T11766 17927-17935 NN denotes scenario
T11767 17936-17938 VBZ denotes is
T11768 17939-17943 IN denotes that
T11769 17944-17955 JJ denotes p53-binding
T11770 17956-17964 NNS denotes proteins
T11771 17964-17965 , denotes ,
T11772 17966-17971 WDT denotes which
T11773 17972-17975 VBP denotes are
T11774 17976-17983 JJ denotes present
T11775 17984-17986 IN denotes in
T11776 17987-17991 NNS denotes GBMs
T11777 17991-17992 , denotes ,
T11778 17993-17996 MD denotes may
T11779 17997-18006 VB denotes interfere
T11780 18007-18011 IN denotes with
T11781 18012-18015 DT denotes the
T11782 18016-18025 JJ denotes apoptotic
T11783 18026-18034 NN denotes function
T11784 18035-18037 IN denotes of
T11785 18038-18042 NNP denotes WWOX
T11786 18043-18046 CC denotes and
T11787 18047-18050 NN denotes p53
T11788 18050-18051 . denotes .
T11789 18052-18062 JJ denotes Functional
T11790 18063-18073 NN denotes antagonism
T11791 18074-18079 IN denotes among
T11792 18080-18085 NN denotes tumor
T11793 18086-18097 NNS denotes suppressors
T11794 18098-18101 VBZ denotes has
T11795 18102-18107 RB denotes never
T11796 18108-18112 VBN denotes been
T11797 18113-18123 VBN denotes documented
T11798 18124-18126 IN denotes in
T11799 18127-18130 DT denotes the
T11800 18131-18141 NN denotes literature
T11801 18141-18142 . denotes .
T11802 18143-18150 RB denotes However
T11803 18150-18151 , denotes ,
T11804 18152-18154 PRP denotes it
T11805 18155-18157 VBZ denotes is
T11806 18158-18161 RB denotes not
T11807 18162-18172 JJ denotes surprising
T11808 18173-18175 TO denotes to
T11809 18176-18180 VB denotes find
T11810 18181-18185 DT denotes that
T11811 18186-18190 JJ denotes many
T11812 18191-18196 NN denotes tumor
T11813 18197-18207 NN denotes suppressor
T11814 18208-18216 NNS denotes proteins
T11815 18216-18217 , denotes ,
T11816 18218-18222 FW denotes e.g.
T11817 18222-18223 , denotes ,
T11818 18224-18227 NN denotes p53
T11819 18227-18228 , denotes ,
T11820 18229-18233 NNP denotes WWOX
T11821 18233-18234 , denotes ,
T11822 18235-18240 NNP denotes Smad4
T11823 18240-18241 , denotes ,
T11824 18242-18246 NNP denotes PTEN
T11825 18246-18247 , denotes ,
T11826 18248-18252 NNP denotes PP2A
T11827 18252-18253 , denotes ,
T11828 18254-18257 CC denotes and
T11829 18258-18262 FW denotes etc.
T11830 18262-18263 , denotes ,
T11831 18264-18267 VBP denotes are
T11832 18268-18281 RB denotes significantly
T11833 18282-18293 VBN denotes upregulated
T11834 18294-18300 IN denotes during
T11835 18301-18304 DT denotes the
T11836 18305-18310 JJ denotes early
T11837 18311-18316 NN denotes stage
T11838 18317-18319 IN denotes of
T11839 18320-18326 NN denotes cancer
T11840 18327-18338 NN denotes progression
T11841 18339-18340 -LRB- denotes (
T11842 18340-18343 NNP denotes Lai
T11843 18344-18346 FW denotes et
T11844 18347-18350 FW denotes al.
T11845 18350-18351 , denotes ,
T11846 18352-18356 CD denotes 2005
T11847 18356-18357 : denotes ;
T11848 18358-18363 NNP denotes Chang
T11849 18364-18366 FW denotes et
T11850 18367-18370 FW denotes al.
T11851 18370-18371 , denotes ,
T11852 18372-18383 JJ denotes unpublished
T11853 18383-18384 -RRB- denotes )
T11854 18384-18385 . denotes .
T11855 18386-18388 VB denotes Do
T11856 18389-18394 DT denotes these
T11857 18395-18403 NNS denotes proteins
T11858 18404-18407 VBP denotes act
T11859 18408-18423 RB denotes synergistically
T11860 18424-18426 IN denotes in
T11861 18427-18435 VBG denotes blocking
T11862 18436-18442 NN denotes cancer
T11863 18443-18454 NN denotes progression
T11864 18455-18458 CC denotes but
T11865 18459-18463 VBP denotes lose
T11866 18464-18471 NN denotes control
T11867 18472-18482 RB denotes eventually
T11868 18482-18483 . denotes ?
T11869 18484-18486 CC denotes Or
T11870 18486-18487 , denotes ,
T11871 18488-18490 VBP denotes do
T11872 18491-18495 PRP denotes they
T11873 18496-18506 VBP denotes counteract
T11874 18507-18511 DT denotes each
T11875 18512-18517 JJ denotes other
T11876 18520-18528 NN denotes function
T11877 18528-18529 , denotes ,
T11878 18530-18534 RB denotes thus
T11879 18535-18543 VBG denotes allowing
T11880 18544-18550 NN denotes cancer
T11881 18551-18557 NN denotes growth
T11882 18557-18558 . denotes ?
T11883 18559-18566 IN denotes Whether
T11884 18567-18577 JJ denotes endogenous
T11885 18578-18582 NNP denotes WWOX
T11886 18583-18594 NNS denotes counteracts
T11887 18595-18599 IN denotes with
T11888 18600-18603 DT denotes the
T11889 18604-18612 NN denotes function
T11890 18613-18615 IN denotes of
T11891 18616-18626 JJ denotes endogenous
T11892 18627-18630 NN denotes p53
T11893 18631-18633 VBZ denotes is
T11894 18634-18641 JJ denotes unknown
T11895 18642-18645 CC denotes and
T11896 18646-18653 VBZ denotes remains
T11897 18654-18656 TO denotes to
T11898 18657-18659 VB denotes be
T11899 18660-18671 VBN denotes established
T11900 18671-18672 . denotes .
T11901 18673-18676 CD denotes One
T11902 18677-18679 IN denotes of
T11903 18680-18683 DT denotes the
T11904 18684-18690 JJ denotes unique
T11905 18691-18706 NNS denotes characteristics
T11906 18707-18710 IN denotes for
T11907 18711-18720 JJ denotes malignant
T11908 18721-18728 NNS denotes gliomas
T11909 18729-18731 VBZ denotes is
T11910 18732-18737 PRP$ denotes their
T11911 18738-18745 NN denotes diffuse
T11912 18746-18758 NN denotes infiltration
T11913 18759-18763 IN denotes into
T11914 18764-18771 JJ denotes distant
T11915 18772-18777 NN denotes brain
T11916 18778-18784 NN denotes tissue
T11917 18784-18785 . denotes .
T11918 18786-18792 NNP denotes Signal
T11919 18793-18801 NNS denotes pathways
T11920 18801-18802 , denotes ,
T11921 18803-18812 VBG denotes involving
T11922 18813-18817 NNP denotes PI3K
T11923 18817-18818 , denotes ,
T11924 18819-18822 NNP denotes Akt
T11925 18822-18823 , denotes ,
T11926 18824-18828 NNP denotes mTOR
T11927 18828-18829 , denotes ,
T11928 18830-18835 NNP denotes NF-κB
T11929 18835-18836 , denotes ,
T11930 18837-18840 CC denotes and
T11931 18841-18850 NN denotes autophagy
T11932 18850-18851 , denotes ,
T11933 18852-18855 VBP denotes are
T11934 18856-18864 VBN denotes believed
T11935 18865-18867 TO denotes to
T11936 18868-18874 VB denotes confer
T11937 18875-18880 DT denotes these
T11938 18881-18890 VBG denotes migrating
T11939 18891-18896 NNS denotes cells
T11940 18897-18906 JJ denotes resistant
T11941 18907-18909 TO denotes to
T11942 18910-18919 JJ denotes apoptotic
T11943 18920-18925 NN denotes death
T11944 18926-18927 -LRB- denotes (
T11945 18927-18934 NNP denotes Lefranc
T11946 18935-18937 FW denotes et
T11947 18938-18941 FW denotes al.
T11948 18941-18942 , denotes ,
T11949 18943-18947 CD denotes 2005
T11950 18947-18948 -RRB- denotes )
T11951 18948-18949 . denotes .
T11952 18950-18956 NNP denotes Glioma
T11953 18957-18962 NNS denotes cells
T11954 18963-18970 VBP denotes possess
T11955 18971-18975 NNP denotes CD44
T11956 18976-18978 IN denotes as
T11957 18979-18980 DT denotes a
T11958 18981-18989 NN denotes receptor
T11959 18990-18993 IN denotes for
T11960 18994-19005 VBG denotes interacting
T11961 19006-19010 IN denotes with
T11962 19011-19016 NN denotes brain
T11963 19017-19023 NN denotes matrix
T11964 19024-19034 NN denotes hyaluronan
T11965 19035-19036 -LRB- denotes (
T11966 19036-19041 NNP denotes Murai
T11967 19042-19044 FW denotes et
T11968 19045-19048 FW denotes al.
T11969 19048-19049 , denotes ,
T11970 19050-19054 CD denotes 2004
T11971 19054-19055 : denotes ;
T11972 19056-19063 NNP denotes Yoshida
T11973 19064-19066 FW denotes et
T11974 19067-19070 FW denotes al.
T11975 19070-19071 , denotes ,
T11976 19072-19076 CD denotes 2012
T11977 19076-19077 -RRB- denotes )
T11978 19077-19078 , denotes ,
T11979 19079-19082 CC denotes and
T11980 19083-19090 NN denotes secrete
T11981 19091-19105 NNS denotes hyaluronidases
T11982 19106-19109 CC denotes and
T11983 19110-19128 NNS denotes metalloproteinases
T11984 19129-19131 TO denotes to
T11985 19132-19142 VB denotes facilitate
T11986 19143-19148 PRP$ denotes their
T11987 19149-19158 NN denotes migration
T11988 19159-19160 -LRB- denotes (
T11989 19160-19167 NNP denotes Delpech
T11990 19168-19170 FW denotes et
T11991 19171-19174 FW denotes al.
T11992 19174-19175 , denotes ,
T11993 19176-19180 CD denotes 2002
T11994 19180-19181 : denotes ;
T11995 19182-19188 NNP denotes Junker
T11996 19189-19191 FW denotes et
T11997 19192-19195 FW denotes al.
T11998 19195-19196 , denotes ,
T11999 19197-19201 CD denotes 2003
T12000 19201-19202 : denotes ;
T12001 19203-19211 NNP denotes Hagemann
T12002 19212-19214 FW denotes et
T12003 19215-19218 FW denotes al.
T12004 19218-19219 , denotes ,
T12005 19220-19224 CD denotes 2012
T12006 19224-19225 -RRB- denotes )
T12007 19225-19226 . denotes .
T12008 19227-19231 RB denotes Also
T12009 19231-19232 , denotes ,
T12010 19233-19237 NN denotes lack
T12011 19238-19240 IN denotes of
T12012 19241-19245 NNP denotes WWOX
T12013 19246-19256 NN denotes expression
T12014 19257-19259 VBZ denotes is
T12015 19260-19268 VBN denotes expected
T12016 19269-19271 TO denotes to
T12017 19272-19279 VB denotes enhance
T12018 19280-19284 NN denotes cell
T12019 19285-19294 NN denotes migration
T12020 19294-19295 . denotes .
T12021 19296-19299 IN denotes For
T12022 19300-19307 NN denotes example
T12023 19307-19308 , denotes ,
T12024 19309-19313 NN denotes loss
T12025 19314-19316 IN denotes of
T12026 19317-19321 NNP denotes WWOX
T12027 19322-19333 VBZ denotes facilitates
T12028 19334-19343 NN denotes migration
T12029 19344-19346 IN denotes of
T12030 19347-19354 JJ denotes ovarian
T12031 19355-19361 NN denotes cancer
T12032 19362-19365 CC denotes and
T12033 19366-19378 NN denotes osteosarcoma
T12034 19379-19384 NNS denotes cells
T12035 19385-19386 -LRB- denotes (
T12036 19386-19393 NNP denotes Gourley
T12037 19394-19396 FW denotes et
T12038 19397-19400 FW denotes al.
T12039 19400-19401 , denotes ,
T12040 19402-19406 CD denotes 2009
T12041 19406-19407 : denotes ;
T12042 19408-19411 NNP denotes Del
T12043 19412-19416 NNP denotes Mare
T12044 19417-19419 FW denotes et
T12045 19420-19423 FW denotes al.
T12046 19423-19424 , denotes ,
T12047 19425-19429 CD denotes 2011
T12048 19429-19430 -RRB- denotes )
T12049 19430-19431 . denotes .
T12050 19432-19439 JJ denotes Ectopic
T12051 19440-19450 NN denotes expression
T12052 19451-19453 IN denotes of
T12053 19454-19459 CD denotes TIAF1
T12054 19460-19461 -LRB- denotes (
T12055 19461-19474 JJ denotes TGF-β-induced
T12056 19475-19488 JJ denotes antiapoptotic
T12057 19489-19495 NN denotes factor
T12058 19495-19496 -RRB- denotes )
T12059 19496-19497 , denotes ,
T12060 19498-19501 NN denotes p53
T12061 19501-19502 , denotes ,
T12062 19503-19506 CC denotes and
T12063 19507-19511 NNP denotes WWOX
T12064 19512-19522 VBZ denotes suppresses
T12065 19523-19544 JJ denotes anchorage-independent
T12066 19545-19551 NN denotes growth
T12067 19552-19555 CC denotes and
T12068 19556-19560 NN denotes cell
T12069 19561-19570 NN denotes migration
T12070 19571-19574 CC denotes and
T12071 19575-19581 VBZ denotes causes
T12072 19582-19591 NN denotes apoptosis
T12073 19592-19594 IN denotes in
T12074 19595-19601 NN denotes cancer
T12075 19602-19607 NNS denotes cells
T12076 19608-19609 -LRB- denotes (
T12077 19609-19614 NNP denotes Chang
T12078 19615-19617 FW denotes et
T12079 19618-19621 FW denotes al.
T12080 19621-19622 , denotes ,
T12081 19623-19627 CD denotes 2012
T12082 19627-19628 -RRB- denotes )
T12083 19628-19629 . denotes .
T12084 19630-19632 PRP denotes We
T12085 19633-19640 VBP denotes believe
T12086 19641-19645 IN denotes that
T12087 19646-19652 NN denotes glioma
T12088 19653-19658 NNS denotes cells
T12089 19658-19659 , denotes ,
T12090 19660-19664 IN denotes with
T12091 19665-19669 NN denotes stem
T12092 19670-19679 JJ denotes cell-like
T12093 19680-19690 NNS denotes properties
T12094 19690-19691 , denotes ,
T12095 19692-19699 VB denotes migrate
T12096 19700-19712 RB denotes individually
T12097 19713-19719 RB denotes rather
T12098 19720-19724 IN denotes than
T12099 19725-19737 RB denotes collectively
T12100 19737-19738 . denotes .
T12101 19739-19743 DT denotes This
T12102 19744-19754 NN denotes assumption
T12103 19755-19757 VBZ denotes is
T12104 19758-19763 VBN denotes based
T12105 19764-19768 IN denotes upon
T12106 19769-19772 PRP$ denotes our
T12107 19773-19785 NNS denotes observations
T12108 19786-19790 IN denotes that
T12109 19791-19796 NN denotes mouse
T12110 19797-19801 NNP denotes Wwox
T12111 19802-19806 NN denotes gene
T12112 19807-19815 NN denotes knockout
T12113 19816-19821 NNS denotes cells
T12114 19822-19823 -LRB- denotes (
T12115 19823-19827 FW denotes e.g.
T12116 19827-19828 , denotes ,
T12117 19829-19838 JJ denotes embryonic
T12118 19839-19850 NNS denotes fibroblasts
T12119 19850-19851 -RRB- denotes )
T12120 19852-19859 VBP denotes migrate
T12121 19860-19872 RB denotes individually
T12122 19873-19876 CC denotes and
T12123 19877-19889 RB denotes aggressively
T12124 19889-19890 . denotes .
T12125 19891-19893 IN denotes In
T12126 19894-19902 NN denotes contrast
T12127 19902-19903 , denotes ,
T12128 19904-19908 JJ denotes wild
T12129 19909-19913 NN denotes type
T12130 19914-19919 NNS denotes cells
T12131 19920-19927 VBP denotes migrate
T12132 19928-19940 RB denotes collectively
T12133 19941-19942 -LRB- denotes (
T12134 19942-19946 NNP denotes Chou
T12135 19947-19949 FW denotes et
T12136 19950-19953 FW denotes al.
T12137 19953-19954 , denotes ,
T12138 19955-19966 JJ denotes unpublished
T12139 19966-19967 -RRB- denotes )
T12140 19967-19968 . denotes .
T12141 19969-19974 IN denotes While
T12142 19975-19976 DT denotes a
T12143 19977-19984 NN denotes portion
T12144 19985-19987 IN denotes of
T12145 19988-19992 NNP denotes WWOX
T12146 19993-19995 VBZ denotes is
T12147 19996-20004 VBN denotes anchored
T12148 20005-20007 IN denotes on
T12149 20008-20011 DT denotes the
T12150 20012-20016 NN denotes cell
T12151 20017-20038 NN denotes membrane/cytoskeleton
T12152 20038-20039 , denotes ,
T12153 20040-20053 JJ denotes WWOX-negative
T12154 20054-20059 NNS denotes cells
T12155 20060-20064 VBP denotes lose
T12156 20065-20076 NN denotes recognition
T12157 20077-20079 IN denotes by
T12158 20080-20088 JJ denotes parental
T12159 20089-20102 JJ denotes WWOX-positive
T12160 20103-20108 NNS denotes cells
T12161 20108-20109 , denotes ,
T12162 20110-20113 CC denotes and
T12163 20114-20118 DT denotes this
T12164 20119-20128 VBZ denotes increases
T12165 20129-20132 DT denotes the
T12166 20133-20141 NN denotes mobility
T12167 20142-20144 IN denotes of
T12168 20145-20158 JJ denotes WWOX-negative
T12169 20159-20164 NNS denotes cells
T12170 20165-20167 TO denotes to
T12171 20168-20172 VB denotes move
T12172 20173-20177 RB denotes away
T12173 20178-20182 IN denotes from
T12174 20183-20186 DT denotes the
T12175 20187-20200 JJ denotes WWOX-positive
T12176 20201-20206 NNS denotes cells
T12177 20206-20207 . denotes .
T12178 20208-20219 RB denotes Conceivably
T12179 20219-20220 , denotes ,
T12180 20221-20234 JJ denotes WWOX-negative
T12181 20235-20241 NN denotes glioma
T12182 20242-20247 NNS denotes cells
T12183 20248-20255 VBP denotes migrate
T12184 20256-20268 RB denotes individually
T12185 20269-20272 CC denotes and
T12186 20273-20277 VB denotes turn
T12187 20278-20282 RB denotes away
T12188 20283-20287 IN denotes from
T12189 20288-20303 JJ denotes WWOX-expressing
T12190 20304-20309 NN denotes brain
T12191 20310-20315 NNS denotes cells
T12192 20316-20318 TO denotes to
T12193 20319-20322 JJ denotes low
T12194 20323-20327 NNP denotes WWOX
T12195 20328-20338 NN denotes expression
T12196 20339-20344 NNS denotes areas
T12197 20344-20345 . denotes .
T12198 20346-20356 RB denotes Apparently
T12199 20356-20357 , denotes ,
T12200 20358-20361 DT denotes the
T12201 20362-20371 JJ denotes migratory
T12202 20372-20380 NN denotes behavior
T12203 20381-20383 IN denotes of
T12204 20384-20397 JJ denotes WWOX-negative
T12205 20398-20404 NN denotes glioma
T12206 20405-20410 NNS denotes cells
T12207 20411-20414 MD denotes may
T12208 20415-20422 VB denotes account
T12209 20423-20426 IN denotes for
T12210 20427-20430 DT denotes the
T12211 20431-20438 NN denotes diffuse
T12212 20439-20447 NN denotes invasion
T12213 20448-20452 IN denotes into
T12214 20453-20460 JJ denotes distant
T12215 20461-20466 NN denotes brain
T12216 20467-20473 NN denotes tissue
T12217 20474-20475 -LRB- denotes (
T12218 20475-20479 NNP denotes Chou
T12219 20480-20482 FW denotes et
T12220 20483-20486 FW denotes al.
T12221 20486-20487 , denotes ,
T12222 20488-20499 JJ denotes unpublished
T12223 20499-20500 -RRB- denotes )
T12224 20500-20501 . denotes .
T12225 20502-20511 JJ denotes Metabolic
T12226 20512-20523 NNS denotes alterations
T12227 20524-20528 VBP denotes have
T12228 20529-20533 VBN denotes been
T12229 20534-20539 VBN denotes shown
T12230 20540-20542 IN denotes in
T12231 20543-20547 NNP denotes Wwox
T12232 20548-20556 NN denotes knockout
T12233 20557-20561 NNS denotes mice
T12234 20561-20562 , denotes ,
T12235 20563-20572 VBG denotes including
T12236 20573-20582 JJ denotes postnatal
T12237 20583-20592 NN denotes lethality
T12238 20592-20593 , denotes ,
T12239 20594-20598 NN denotes bone
T12240 20599-20609 NN denotes metabolism
T12241 20610-20617 NNS denotes defects
T12242 20617-20618 , denotes ,
T12243 20619-20625 NN denotes ataxia
T12244 20625-20626 , denotes ,
T12245 20627-20642 NN denotes steroidogenesis
T12246 20642-20643 , denotes ,
T12247 20644-20647 CC denotes and
T12248 20648-20658 NN denotes generation
T12249 20659-20661 IN denotes of
T12250 20662-20675 NNS denotes osteosarcomas
T12251 20676-20677 -LRB- denotes (
T12252 20677-20680 NNP denotes Del
T12253 20681-20685 NNP denotes Mare
T12254 20686-20688 FW denotes et
T12255 20689-20692 FW denotes al.
T12256 20692-20693 , denotes ,
T12257 20694-20698 CD denotes 2011
T12258 20698-20699 : denotes ;
T12259 20700-20705 NNP denotes Salah
T12260 20706-20708 FW denotes et
T12261 20709-20712 FW denotes al.
T12262 20712-20713 , denotes ,
T12263 20714-20718 CD denotes 2012
T12264 20718-20719 -RRB- denotes )
T12265 20719-20720 . denotes .
T12266 20721-20723 IN denotes In
T12267 20724-20725 DT denotes a
T12268 20726-20736 NNP denotes Drosophila
T12269 20737-20742 NN denotes model
T12270 20742-20743 , denotes ,
T12271 20744-20748 NNP denotes Wwox
T12272 20749-20751 VBZ denotes is
T12273 20752-20757 VBN denotes shown
T12274 20758-20760 TO denotes to
T12275 20761-20772 VB denotes participate
T12276 20773-20775 IN denotes in
T12277 20776-20784 NNS denotes pathways
T12278 20785-20794 VBG denotes involving
T12279 20795-20802 JJ denotes aerobic
T12280 20803-20813 NN denotes metabolism
T12281 20814-20817 CC denotes and
T12282 20818-20827 JJ denotes oxidative
T12283 20828-20834 NN denotes stress
T12284 20835-20838 IN denotes for
T12285 20839-20849 NN denotes generation
T12286 20850-20852 IN denotes of
T12287 20853-20856 NNP denotes ROS
T12288 20857-20858 -LRB- denotes (
T12289 20866-20868 FW denotes et
T12290 20869-20872 FW denotes al.
T12291 20872-20873 , denotes ,
T12292 20874-20878 CD denotes 2011
T12293 20878-20879 -RRB- denotes )
T12294 20879-20880 . denotes .
T12295 20881-20886 IN denotes Under
T12296 20887-20889 NNP denotes UV
T12297 20890-20896 NN denotes stress
T12298 20896-20897 , denotes ,
T12299 20898-20908 JJ denotes functional
T12300 20909-20913 NNP denotes Wwox
T12301 20914-20918 NN denotes gene
T12302 20919-20929 NN denotes expression
T12303 20930-20937 VBZ denotes induces
T12304 20938-20941 NNP denotes ROS
T12305 20942-20952 NN denotes production
T12306 20953-20955 IN denotes in
T12307 20956-20966 NNP denotes Drosophila
T12308 20966-20967 . denotes .
T12309 20968-20974 NNP denotes Cancer
T12310 20975-20980 NNS denotes cells
T12311 20981-20984 VBP denotes are
T12312 20985-20990 VBN denotes known
T12313 20991-20993 TO denotes to
T12314 20994-21000 RB denotes overly
T12315 21001-21008 VB denotes utilize
T12316 21009-21019 NN denotes glycolysis
T12317 21020-21023 IN denotes for
T12318 21024-21030 NN denotes growth
T12319 21031-21040 NN denotes advantage
T12320 21043-21046 DT denotes the
T12321 21047-21056 JJ denotes so-called
T12322 21057-21064 NNP denotes Warburg
T12323 21065-21066 -LRB- denotes (
T12324 21066-21073 NNP denotes Moncada
T12325 21074-21076 FW denotes et
T12326 21077-21080 FW denotes al.
T12327 21080-21081 , denotes ,
T12328 21082-21086 CD denotes 2012
T12329 21086-21087 -RRB- denotes )
T12330 21087-21088 . denotes .
T12331 21089-21100 RB denotes Conceivably
T12332 21100-21101 , denotes ,
T12333 21102-21106 NNP denotes WWOX
T12334 21107-21109 VBZ denotes is
T12335 21110-21116 JJ denotes likely
T12336 21117-21119 TO denotes to
T12337 21120-21128 VB denotes override
T12338 21129-21136 NN denotes glucose
T12339 21137-21148 NN denotes consumption
T12340 21149-21151 IN denotes in
T12341 21152-21158 NN denotes cancer
T12342 21159-21164 NNS denotes cells
T12343 21165-21168 CC denotes and
T12344 21169-21175 NNS denotes exerts
T12345 21176-21186 NN denotes generation
T12346 21187-21189 IN denotes of
T12347 21190-21193 NNP denotes ROS
T12348 21194-21196 TO denotes to
T12349 21197-21201 VB denotes curb
T12350 21202-21205 DT denotes the
T12351 21206-21212 NN denotes cancer
T12352 21213-21217 NN denotes cell
T12353 21218-21224 NN denotes growth
T12354 21225-21228 CC denotes and
T12355 21229-21237 NN denotes invasion
T12356 21237-21238 . denotes .
T12357 21239-21241 IN denotes In
T12358 21242-21249 NN denotes summary
T12359 21249-21250 , denotes ,
T12360 21251-21253 IN denotes in
T12361 21254-21258 DT denotes this
T12362 21259-21270 NN denotes perspective
T12363 21271-21278 NN denotes article
T12364 21279-21281 PRP denotes we
T12365 21282-21286 VBP denotes have
T12366 21287-21296 VBN denotes discussed
T12367 21297-21300 DT denotes the
T12368 21301-21310 JJ denotes potential
T12369 21311-21315 NN denotes role
T12370 21316-21318 IN denotes of
T12371 21319-21324 NN denotes tumor
T12372 21325-21336 NNS denotes suppressors
T12373 21337-21340 NN denotes p53
T12374 21341-21344 CC denotes and
T12375 21345-21349 NNP denotes WWOX
T12376 21350-21352 IN denotes in
T12377 21353-21363 VBG denotes regulating
T12378 21364-21367 NNP denotes TMZ
T12379 21368-21379 NN denotes sensitivity
T12380 21380-21382 IN denotes in
T12381 21383-21386 NNP denotes GBM
T12382 21387-21392 NNS denotes cells
T12383 21392-21393 . denotes .
T12384 21394-21396 PRP denotes We
T12385 21397-21401 VBP denotes have
T12386 21402-21407 VBN denotes shown
T12387 21408-21411 DT denotes the
T12388 21412-21416 NN denotes role
T12389 21417-21419 IN denotes of
T12390 21420-21424 NNP denotes WWOX
T12391 21425-21427 IN denotes in
T12392 21428-21439 VBG denotes controlling
T12393 21440-21444 NN denotes cell
T12394 21445-21454 NN denotes migration
T12395 21455-21458 CC denotes and
T12396 21459-21468 JJ denotes metabolic
T12397 21469-21480 NNS denotes alterations
T12398 21480-21481 , denotes ,
T12399 21482-21485 CC denotes and
T12400 21486-21495 VBD denotes discussed
T12401 21496-21499 DT denotes the
T12402 21500-21507 NNS denotes effects
T12403 21508-21510 IN denotes of
T12404 21511-21515 NNP denotes WWOX
T12405 21516-21526 NN denotes deficiency
T12406 21527-21530 CC denotes and
T12407 21531-21534 NNP denotes TMZ
T12408 21535-21545 NN denotes resistance
T12409 21546-21548 IN denotes in
T12410 21549-21555 NN denotes cancer
T12411 21556-21561 NNS denotes cells
T12412 21561-21562 . denotes .
T12540 21585-21592 NNP denotes Ming-Fu
T12541 21593-21599 NNP denotes Chiang
T12542 21600-21603 CC denotes and
T12543 21604-21610 NNP denotes Chun-I
T12544 21611-21614 NNP denotes Sze
T12545 21615-21620 VBD denotes wrote
T12546 21621-21624 DT denotes the
T12547 21625-21633 NNS denotes sections
T12548 21634-21641 VBG denotes dealing
T12549 21642-21646 IN denotes with
T12550 21647-21650 NNP denotes TMZ
T12551 21650-21651 : denotes ;
T12552 21652-21658 NNP denotes Pei-Yi
T12553 21659-21663 NNP denotes Chou
T12554 21664-21669 VBD denotes wrote
T12555 21670-21673 DT denotes the
T12556 21674-21680 NN denotes review
T12557 21681-21689 NNS denotes sections
T12558 21690-21693 IN denotes for
T12559 21694-21697 NN denotes p53
T12560 21698-21701 CC denotes and
T12561 21702-21706 NNP denotes WWOX
T12562 21707-21710 CC denotes and
T12563 21711-21719 VBN denotes designed
T12564 21720-21726 NNS denotes graphs
T12565 21726-21727 : denotes ;
T12566 21728-21735 NNP denotes Wan-Jen
T12567 21736-21740 NNP denotes Wang
T12568 21741-21748 VBD denotes managed
T12569 21749-21758 NNS denotes citations
T12570 21758-21759 : denotes ;
T12571 21760-21768 NNP denotes Nan-Shan
T12572 21769-21774 NNP denotes Chang
T12573 21775-21784 VBD denotes conceived
T12574 21785-21790 NNS denotes ideas
T12575 21790-21791 , denotes ,
T12576 21792-21797 VBD denotes wrote
T12577 21798-21801 CC denotes and
T12578 21802-21812 RB denotes thoroughly
T12579 21813-21820 VBD denotes revised
T12580 21821-21824 DT denotes the
T12581 21825-21835 NN denotes manuscript
T12582 21835-21836 , denotes ,
T12583 21837-21840 CC denotes and
T12584 21841-21850 VBN denotes discussed
T12585 21851-21855 IN denotes with
T12586 21856-21865 NNS denotes coauthors
T12587 21865-21866 . denotes .
T12618 21899-21902 DT denotes The
T12619 21903-21910 NNS denotes authors
T12620 21911-21918 VBP denotes declare
T12621 21919-21923 IN denotes that
T12622 21924-21927 DT denotes the
T12623 21928-21936 NN denotes research
T12624 21937-21940 VBD denotes was
T12625 21941-21950 VBN denotes conducted
T12626 21951-21953 IN denotes in
T12627 21954-21957 DT denotes the
T12628 21958-21965 NN denotes absence
T12629 21966-21968 IN denotes of
T12630 21969-21972 DT denotes any
T12631 21973-21983 JJ denotes commercial
T12632 21984-21986 CC denotes or
T12633 21987-21996 JJ denotes financial
T12634 21997-22010 NNS denotes relationships
T12635 22011-22015 WDT denotes that
T12636 22016-22021 MD denotes could
T12637 22022-22024 VB denotes be
T12638 22025-22034 VBN denotes construed
T12639 22035-22037 IN denotes as
T12640 22038-22039 DT denotes a
T12641 22040-22049 JJ denotes potential
T12642 22050-22058 NN denotes conflict
T12643 22059-22061 IN denotes of
T12644 22062-22070 NN denotes interest
T12645 22070-22071 . denotes .
R10000 T14574 T14576 amod N-terminal,mutants
R10001 T14575 T14576 compound deletion,mutants
R10002 T14576 T14581 nsubjpass mutants,shown
R10003 T14577 T14576 prep of,mutants
R10004 T14578 T14577 pobj p53,of
R10005 T14579 T14581 auxpass are,shown
R10006 T14580 T14581 advmod also,shown
R10007 T14581 T14581 ROOT shown,shown
R10008 T14582 T14581 punct .,shown
R10009 T14583 T14584 punct (,B
R10010 T14584 T14584 ROOT B,B
R10011 T14585 T14584 punct ),B
R10012 T14586 T14588 nummod Three,scenarios
R10013 T14587 T14588 amod likely,scenarios
R10014 T14588 T14590 nsubjpass scenarios,proposed
R10015 T14589 T14590 auxpass are,proposed
R10016 T14590 T14590 ROOT proposed,proposed
R10017 T14591 T14590 prep for,proposed
R10018 T14592 T14591 pobj WWOX,for
R10019 T14593 T14592 cc and,WWOX
R10020 T14594 T14592 conj p53,WWOX
R10021 T14595 T14596 aux to,regulate
R10022 T14596 T14590 advcl regulate,proposed
R10023 T14597 T14599 compound GBM,death
R10024 T14598 T14599 compound cell,death
R10025 T14599 T14596 dobj death,regulate
R10026 T14600 T14590 punct .,proposed
R10027 T14601 T14605 advmod First,fails
R10028 T14602 T14605 punct ",",fails
R10029 T14603 T14604 compound ectopic,WWOX
R10030 T14604 T14605 nsubj WWOX,fails
R10031 T14605 T14605 ROOT fails,fails
R10032 T14606 T14607 aux to,induce
R10033 T14607 T14605 xcomp induce,fails
R10034 T14608 T14607 dobj apoptosis,induce
R10035 T14609 T14608 prep of,apoptosis
R10036 T14610 T14611 compound GBM,cells
R10037 T14611 T14609 pobj cells,of
R10038 T14612 T14611 acl expressing,cells
R10039 T14613 T14616 amod endogenous,p53
R10040 T14614 T14615 amod wild,type
R10041 T14615 T14616 compound type,p53
R10042 T14616 T14612 dobj p53,expressing
R10043 T14617 T14605 punct .,fails
R10044 T14618 T14619 nsubj It,appears
R10045 T14619 T14619 ROOT appears,appears
R10046 T14620 T14623 mark that,binds
R10047 T14621 T14622 compound ectopic,WWOX
R10048 T14622 T14623 compound WWOX,binds
R10049 T14623 T14632 nsubj binds,nullify
R10050 T14624 T14623 cc and,binds
R10051 T14625 T14626 advmod functionally,antagonizes
R10052 T14626 T14623 conj antagonizes,binds
R10053 T14627 T14626 dobj p53,antagonizes
R10054 T14628 T14626 punct ",",antagonizes
R10055 T14629 T14626 cc and,antagonizes
R10056 T14630 T14631 det both,proteins
R10057 T14631 T14626 conj proteins,antagonizes
R10058 T14632 T14619 ccomp nullify,appears
R10059 T14633 T14634 det each,other
R10060 T14634 T14635 poss other,function
R10061 T14635 T14632 dobj function,nullify
R10062 T14636 T14632 prep in,nullify
R10063 T14637 T14636 pcomp inducing,in
R10064 T14638 T14637 dobj apoptosis,inducing
R10065 T14639 T14619 punct .,appears
R10066 T14640 T14652 advmod Second,expected
R10067 T14641 T14652 punct ",",expected
R10068 T14642 T14644 det no,interactions
R10069 T14643 T14644 amod physical,interactions
R10070 T14644 T14652 nsubjpass interactions,expected
R10071 T14645 T14644 prep between,interactions
R10072 T14646 T14648 amod mutant,proteins
R10073 T14647 T14648 compound p53,proteins
R10074 T14648 T14645 pobj proteins,between
R10075 T14649 T14648 cc and,proteins
R10076 T14650 T14648 conj WWOX,proteins
R10077 T14651 T14652 auxpass are,expected
R10078 T14652 T14652 ROOT expected,expected
R10079 T14653 T14652 prep in,expected
R10080 T14654 T14655 compound GBM,cells
R10081 T14655 T14653 pobj cells,in
R10082 T14656 T14652 punct .,expected
R10083 T14657 T14661 advmod Thus,induce
R10084 T14658 T14661 punct ",",induce
R10085 T14659 T14661 nsubj ectopic,induce
R10086 T14660 T14661 nsubj WWOX,induce
R10087 T14661 T14661 ROOT induce,induce
R10088 T14662 T14661 dobj apoptosis,induce
R10089 T14663 T14662 prep in,apoptosis
R10090 T14664 T14666 amod mutant,cells
R10091 T14665 T14666 amod p53-expressing,cells
R10092 T14666 T14663 pobj cells,in
R10093 T14667 T14661 punct .,induce
R10094 T14668 T14675 advmod Finally,is
R10095 T14669 T14675 punct ",",is
R10096 T14670 T14672 mark whether,binds
R10097 T14671 T14672 nsubj WWOX,binds
R10098 T14672 T14675 csubj binds,is
R10099 T14673 T14674 compound p53,isoforms
R10100 T14674 T14672 dobj isoforms,binds
R10101 T14675 T14675 ROOT is,is
R10102 T14676 T14675 acomp unknown,is
R10103 T14677 T14675 punct .,is
R10104 T14678 T14692 advmod Also,remains
R10105 T14679 T14692 punct ",",remains
R10106 T14680 T14692 mark whether,remains
R10107 T14681 T14683 amod ectopic,induction
R10108 T14682 T14683 compound WWOX,induction
R10109 T14683 T14692 nsubj induction,remains
R10110 T14684 T14683 prep of,induction
R10111 T14685 T14684 pobj apoptosis,of
R10112 T14686 T14683 prep in,induction
R10113 T14687 T14688 compound GBM,cells
R10114 T14688 T14686 pobj cells,in
R10115 T14689 T14692 csubj expressing,remains
R10116 T14690 T14691 compound p53,isoforms
R10117 T14691 T14689 dobj isoforms,expressing
R10118 T14692 T14692 ROOT remains,remains
R10119 T14693 T14695 aux to,established
R10120 T14694 T14695 auxpass be,established
R10121 T14695 T14692 xcomp established,remains
R10122 T14696 T14692 punct .,remains
R10123 T14697 T14700 nmod TAD,domain
R10124 T14698 T14700 punct ",",domain
R10125 T14699 T14700 amod transactivation,domain
R10126 T14700 T14700 ROOT domain,domain
R10127 T14701 T14700 punct ;,domain
R10128 T14702 T14705 nmod PrD,domain
R10129 T14703 T14705 punct ",",domain
R10130 T14704 T14705 compound proline,domain
R10131 T14705 T14700 appos domain,domain
R10132 T14706 T14700 punct ;,domain
R10133 T14707 T14711 nmod NLS,signal
R10134 T14708 T14707 punct ",",NLS
R10135 T14709 T14710 amod nuclear,localization
R10136 T14710 T14711 compound localization,signal
R10137 T14711 T14711 ROOT signal,signal
R10138 T14712 T14711 punct ;,signal
R10139 T14713 T14716 nmod OD,domain
R10140 T14714 T14716 punct ",",domain
R10141 T14715 T14716 amod oligomerization,domain
R10142 T14716 T14700 conj domain,domain
R10143 T14717 T14716 punct ;,domain
R10144 T14718 T14721 nmod BR,region
R10145 T14719 T14721 punct ",",region
R10146 T14720 T14721 amod basic,region
R10147 T14721 T14716 npadvmod region,domain
R10148 T14722 T14700 punct .,domain
R1576 T2518 T2516 npadvmod 2000,al.
R1577 T2519 T2516 punct ;,al.
R1578 T2520 T2522 compound Stupp,al.
R1579 T2521 T2522 compound et,al.
R1580 T2503 T2504 compound Glioblastoma,multiforme
R1581 T2522 T2505 prep al.,afflicts
R1582 T2504 T2505 nsubj multiforme,afflicts
R1583 T2505 T2528 ccomp afflicts,al.
R1584 T2523 T2522 punct ",",al.
R1585 T2506 T2508 nummod "12,500",patients
R1586 T2524 T2522 npadvmod 2009,al.
R1587 T2507 T2508 amod new,patients
R1588 T2508 T2505 dobj patients,afflicts
R1589 T2509 T2508 prep in,patients
R1590 T2510 T2511 det the,U.S.
R1591 T2525 T2528 punct ;,al.
R1592 T2511 T2509 pobj U.S.,in
R1593 T2512 T2505 advmod annually,afflicts
R1594 T2526 T2528 compound Silber,al.
R1595 T2527 T2528 compound et,al.
R1596 T2528 T2528 ROOT al.,al.
R1597 T2513 T2516 punct (,al.
R1598 T2529 T2528 punct ",",al.
R1599 T2514 T2516 nmod Friedman,al.
R1600 T2515 T2516 nmod et,al.
R1601 T2530 T2528 npadvmod 2012,al.
R1602 T2516 T2522 compound al.,al.
R1603 T2517 T2516 punct ",",al.
R1604 T2531 T2528 punct ),al.
R1605 T2532 T2528 punct .,al.
R1606 T2533 T2537 nsubj Glioblastoma,is
R1607 T2534 T2535 punct (,GBM
R1608 T2570 T2571 compound et,al.
R1609 T2571 T2558 attr al.,is
R1610 T2535 T2533 appos GBM,Glioblastoma
R1611 T2572 T2571 punct ",",al.
R1612 T2573 T2571 npadvmod 2009,al.
R1613 T2574 T2558 punct ),is
R1614 T2536 T2533 punct ),Glioblastoma
R1615 T2575 T2546 punct .,is
R1616 T2576 T2577 amod High,levels
R1617 T2537 T2537 ROOT is,is
R1618 T2577 T2589 nsubjpass levels,seen
R1619 T2578 T2577 prep of,levels
R1620 T2579 T2578 pobj resistance,of
R1621 T2538 T2539 advmod highly,lethal
R1622 T2580 T2579 prep to,resistance
R1623 T2581 T2583 amod current,modalities
R1624 T2582 T2583 amod therapeutic,modalities
R1625 T2539 T2537 acomp lethal,is
R1626 T2583 T2580 pobj modalities,to
R1627 T2584 T2583 cc and,modalities
R1628 T2585 T2586 compound cancer,relapse
R1629 T2586 T2583 conj relapse,modalities
R1630 T2540 T2537 punct ",",is
R1631 T2587 T2589 auxpass are,seen
R1632 T2588 T2589 advmod frequently,seen
R1633 T2541 T2537 cc and,is
R1634 T2589 T2601 ccomp seen,al.
R1635 T2542 T2545 det the,expectancy
R1636 T2590 T2589 prep in,seen
R1637 T2543 T2545 amod average,expectancy
R1638 T2591 T2590 pobj patients,in
R1639 T2544 T2545 compound survival,expectancy
R1640 T2545 T2546 nsubj expectancy,is
R1641 T2592 T2595 punct (,al.
R1642 T2546 T2537 conj is,is
R1643 T2593 T2595 nmod Haar,al.
R1644 T2594 T2595 nmod et,al.
R1645 T2595 T2601 dep al.,al.
R1646 T2547 T2548 nummod 14.6,months
R1647 T2596 T2595 punct ",",al.
R1648 T2597 T2595 npadvmod 2012,al.
R1649 T2548 T2546 attr months,is
R1650 T2598 T2601 punct ;,al.
R1651 T2599 T2601 compound Happold,al.
R1652 T2600 T2601 compound et,al.
R1653 T2549 T2546 punct ",",is
R1654 T2601 T2601 ROOT al.,al.
R1655 T2602 T2601 punct ",",al.
R1656 T2603 T2601 npadvmod 2012,al.
R1657 T2604 T2601 punct ),al.
R1658 T2605 T2601 punct .,al.
R1659 T2606 T2609 det The,therapy
R1660 T2550 T2546 cc and,is
R1661 T2607 T2609 amod current,therapy
R1662 T2608 T2609 amod standard,therapy
R1663 T2609 T2613 nsubj therapy,includes
R1664 T2551 T2555 det the,rate
R1665 T2610 T2609 prep for,therapy
R1666 T2611 T2610 pobj GBM,for
R1667 T2612 T2613 advmod mainly,includes
R1668 T2552 T2555 amod overall,rate
R1669 T2613 T2613 ROOT includes,includes
R1670 T2614 T2616 amod maximum,surgery
R1671 T2615 T2616 compound debulking,surgery
R1672 T2553 T2555 amod 5-year,rate
R1673 T2616 T2613 dobj surgery,includes
R1674 T2617 T2616 punct ",",surgery
R1675 T2618 T2616 conj radiation,surgery
R1676 T2554 T2555 compound survival,rate
R1677 T2619 T2618 punct ",",radiation
R1678 T2620 T2618 cc and,radiation
R1679 T2555 T2558 nsubj rate,is
R1680 T2621 T2618 conj treatment,radiation
R1681 T2622 T2616 prep with,surgery
R1682 T2623 T2626 det the,agent
R1683 T2624 T2626 amod monofunctional,agent
R1684 T2556 T2555 prep for,rate
R1685 T2625 T2626 amod alkylating,agent
R1686 T2626 T2627 compound agent,temozolomide
R1687 T2627 T2622 pobj temozolomide,with
R1688 T2557 T2556 pobj GBM,for
R1689 T2628 T2627 punct (,temozolomide
R1690 T2629 T2627 appos TMZ,temozolomide
R1691 T2558 T2546 conj is,is
R1692 T2630 T2627 punct ),temozolomide
R1693 T2631 T2634 punct (,al.
R1694 T2632 T2634 compound Friedman,al.
R1695 T2559 T2560 advmod only,9.8
R1696 T2633 T2634 nmod et,al.
R1697 T2634 T2638 compound al.,Nishikawa
R1698 T2560 T2561 nummod 9.8,%
R1699 T2635 T2634 punct ",",al.
R1700 T2636 T2634 dep 2000,al.
R1701 T2637 T2634 punct ;,al.
R1702 T2561 T2558 attr %,is
R1703 T2638 T2616 appos Nishikawa,surgery
R1704 T2639 T2638 punct ",",Nishikawa
R1705 T2640 T2638 npadvmod 2010,Nishikawa
R1706 T2641 T2638 punct ),Nishikawa
R1707 T2642 T2613 punct .,includes
R1708 T2643 T2644 amod Multiple,mechanisms
R1709 T2562 T2565 punct (,al.
R1710 T2644 T2646 nsubjpass mechanisms,involved
R1711 T2645 T2646 auxpass are,involved
R1712 T2646 T2718 ccomp involved,al.
R1713 T2647 T2646 prep in,involved
R1714 T2563 T2565 compound Friedman,al.
R1715 T2648 T2650 det the,resistance
R1716 T2649 T2650 compound TMZ,resistance
R1717 T2650 T2647 pobj resistance,in
R1718 T2564 T2565 nmod et,al.
R1719 T2651 T2650 punct ",",resistance
R1720 T2652 T2654 nsubj which,include
R1721 T2653 T2654 aux may,include
R1722 T2565 T2558 parataxis al.,is
R1723 T2654 T2650 relcl include,resistance
R1724 T2655 T2657 compound cancer,cells
R1725 T2656 T2657 compound stem,cells
R1726 T2566 T2565 punct ",",al.
R1727 T2657 T2654 dobj cells,include
R1728 T2658 T2657 punct ",",cells
R1729 T2659 T2657 conj microRNAs,cells
R1730 T2567 T2565 npadvmod 2000,al.
R1731 T2660 T2659 punct ",",microRNAs
R1732 T2661 T2662 compound drug,efflux
R1733 T2662 T2659 conj efflux,microRNAs
R1734 T2663 T2662 punct ",",efflux
R1735 T2568 T2558 punct ;,is
R1736 T2664 T2666 compound DNA,repair
R1737 T2665 T2666 compound damage,repair
R1738 T2666 T2662 conj repair,efflux
R1739 T2569 T2571 compound Stupp,al.
R1740 T2764 T2765 aux to,cause
R1741 T2667 T2666 punct ",",repair
R1742 T2668 T2669 compound tumor,cells
R1743 T2765 T2757 advcl cause,trigger
R1744 T2669 T2659 conj cells,microRNAs
R1745 T2766 T2767 compound cell,death
R1746 T2670 T2654 prep under,include
R1747 T2767 T2765 dobj death,cause
R1748 T2671 T2670 pobj hypoxia,under
R1749 T2768 T2765 punct (,cause
R1750 T2769 T2771 compound Kanzawa,al.
R1751 T2672 T2671 punct ",",hypoxia
R1752 T2770 T2771 nmod et,al.
R1753 T2673 T2674 compound histone,deacetylation
R1754 T2674 T2671 appos deacetylation,hypoxia
R1755 T2675 T2674 punct ",",deacetylation
R1756 T2676 T2677 amod epithelial-mesenchymal,transition
R1757 T2677 T2674 appos transition,deacetylation
R1758 T2678 T2677 punct ",",transition
R1759 T2679 T2680 nummod STAT3,kinase
R1760 T2771 T2765 advmod al.,cause
R1761 T2680 T2677 conj kinase,transition
R1762 T2681 T2680 punct ",",kinase
R1763 T2772 T2771 punct ",",al.
R1764 T2682 T2680 cc and,kinase
R1765 T2683 T2684 amod many,others
R1766 T2684 T2680 conj others,kinase
R1767 T2773 T2771 npadvmod 2003,al.
R1768 T2685 T2684 punct (,others
R1769 T2686 T2688 compound Haar,al.
R1770 T2687 T2688 nmod et,al.
R1771 T2774 T2771 punct ),al.
R1772 T2688 T2684 appos al.,others
R1773 T2689 T2688 punct ",",al.
R1774 T2775 T2755 punct .,known
R1775 T2690 T2688 npadvmod 2012,al.
R1776 T2691 T2684 punct ;,others
R1777 T2692 T2694 compound Happold,al.
R1778 T2776 T2791 advmod Also,leads
R1779 T2693 T2694 compound et,al.
R1780 T2694 T2684 conj al.,others
R1781 T2695 T2694 punct ",",al.
R1782 T2777 T2791 punct ",",leads
R1783 T2696 T2694 npadvmod 2012,al.
R1784 T2697 T2718 punct ;,al.
R1785 T2698 T2718 dep Johannessen,al.
R1786 T2778 T2791 nsubj inhibition,leads
R1787 T2699 T2698 cc and,Johannessen
R1788 T2700 T2698 conj Bjerkvig,Johannessen
R1789 T2701 T2700 punct ",",Bjerkvig
R1790 T2702 T2700 npadvmod 2012,Bjerkvig
R1791 T2779 T2778 prep of,inhibition
R1792 T2703 T2700 punct ;,Bjerkvig
R1793 T2704 T2706 compound Kitange,al.
R1794 T2705 T2706 compound et,al.
R1795 T2780 T2781 amod antiapoptotic,Bcl-2
R1796 T2706 T2700 conj al.,Bjerkvig
R1797 T2707 T2706 punct ",",al.
R1798 T2708 T2706 npadvmod 2012,al.
R1799 T2781 T2779 pobj Bcl-2,of
R1800 T2709 T2718 punct ;,al.
R1801 T2710 T2712 compound Kohsaka,al.
R1802 T2711 T2712 compound et,al.
R1803 T2782 T2778 prep by,inhibition
R1804 T2712 T2718 ccomp al.,al.
R1805 T2713 T2712 punct ",",al.
R1806 T2714 T2712 npadvmod 2012,al.
R1807 T2715 T2718 punct ;,al.
R1808 T2716 T2718 compound Zhang,al.
R1809 T2717 T2718 nmod et,al.
R1810 T2783 T2785 det a,inhibitor
R1811 T2718 T2718 ROOT al.,al.
R1812 T2719 T2720 punct ",",2012b
R1813 T2784 T2785 compound pan-Bcl-2,inhibitor
R1814 T2720 T2718 amod 2012b,al.
R1815 T2785 T2782 pobj inhibitor,by
R1816 T2721 T2720 punct ),2012b
R1817 T2722 T2718 punct .,al.
R1818 T2723 T2724 nsubj Temozolomide,induces
R1819 T2786 T2787 punct (,−
R1820 T2724 T2746 ccomp induces,al.
R1821 T2725 T2724 dobj generation,induces
R1822 T2787 T2785 appos −,inhibitor
R1823 T2726 T2725 prep of,generation
R1824 T2727 T2728 compound DNA,lesions
R1825 T2728 T2726 pobj lesions,of
R1826 T2729 T2728 punct ",",lesions
R1827 T2788 T2787 punct ),−
R1828 T2730 T2728 prep including,lesions
R1829 T2731 T2730 pobj O6-methylguanine,including
R1830 T2789 T2791 punct -,leads
R1831 T2732 T2731 punct ",",O6-methylguanine
R1832 T2733 T2731 conj N3-methyladenine,O6-methylguanine
R1833 T2734 T2733 punct ",",N3-methyladenine
R1834 T2790 T2791 nsubj gossypol,leads
R1835 T2735 T2733 cc and,N3-methyladenine
R1836 T2736 T2733 conj N7-methylguanine,N3-methyladenine
R1837 T2737 T2740 punct (,al.
R1838 T2791 T2791 ROOT leads,leads
R1839 T2738 T2740 compound Goellner,al.
R1840 T2739 T2740 nmod et,al.
R1841 T2740 T2731 appos al.,O6-methylguanine
R1842 T2792 T2791 prep to,leads
R1843 T2741 T2740 punct ",",al.
R1844 T2742 T2740 npadvmod 2011,al.
R1845 T2793 T2792 pobj autophagic,to
R1846 T2743 T2746 punct ;,al.
R1847 T2744 T2746 compound Zhang,al.
R1848 T2745 T2746 compound et,al.
R1849 T2794 T2793 dobj death,autophagic
R1850 T2746 T2746 ROOT al.,al.
R1851 T2747 T2748 punct ",",2012b
R1852 T2795 T2793 prep in,autophagic
R1853 T2748 T2746 amod 2012b,al.
R1854 T2796 T2795 pobj gliomas,in
R1855 T2749 T2748 punct ),2012b
R1856 T2750 T2746 punct .,al.
R1857 T2751 T2753 det The,lesion
R1858 T2752 T2753 amod O6-methylguanine,lesion
R1859 T2797 T2791 cc and,leads
R1860 T2753 T2755 nsubjpass lesion,known
R1861 T2754 T2755 auxpass is,known
R1862 T2755 T2755 ROOT known,known
R1863 T2798 T2791 conj enhances,leads
R1864 T2756 T2757 aux to,trigger
R1865 T2757 T2755 xcomp trigger,known
R1866 T2758 T2757 dobj autophagy,trigger
R1867 T2759 T2758 punct ",",autophagy
R1868 T2760 T2761 advmod rather,than
R1869 T2799 T2800 det the,action
R1870 T2761 T2757 prep than,trigger
R1871 T2762 T2761 pobj apoptosis,than
R1872 T2763 T2757 punct ",",trigger
R1873 T2800 T2798 dobj action,enhances
R1874 T2801 T2800 prep of,action
R1875 T2802 T2801 pobj TMZ,of
R1876 T2803 T2806 punct (,al.
R1877 T2861 T2863 dep MAPO2,encodes
R1878 T2862 T2863 nsubj gene,encodes
R1879 T2804 T2806 compound Voss,al.
R1880 T2863 T2863 ROOT encodes,encodes
R1881 T2864 T2867 det a,protein
R1882 T2865 T2867 compound novel,protein
R1883 T2805 T2806 nmod et,al.
R1884 T2866 T2867 compound 37-kDa,protein
R1885 T2867 T2863 dobj protein,encodes
R1886 T2806 T2800 appos al.,action
R1887 T2868 T2863 punct .,encodes
R1888 T2869 T2872 nsubjpass It,determined
R1889 T2870 T2872 auxpass is,determined
R1890 T2871 T2872 neg not,determined
R1891 T2807 T2806 punct ",",al.
R1892 T2872 T2872 ROOT determined,determined
R1893 T2873 T2876 mark whether,is
R1894 T2874 T2875 det this,gene
R1895 T2808 T2806 npadvmod 2010,al.
R1896 T2875 T2876 nsubj gene,is
R1897 T2809 T2798 punct ),enhances
R1898 T2810 T2791 punct .,leads
R1899 T2876 T2877 auxpass is,involved
R1900 T2877 T2872 xcomp involved,determined
R1901 T2811 T2816 advmod However,demonstrated
R1902 T2878 T2877 prep in,involved
R1903 T2879 T2878 pobj autophagy,in
R1904 T2812 T2816 punct ",",demonstrated
R1905 T2880 T2872 punct .,determined
R1906 T2881 T2883 det The,lesion
R1907 T2882 T2883 amod O6-methylguanine,lesion
R1908 T2883 T2884 nsubj lesion,is
R1909 T2884 T2884 ROOT is,is
R1910 T2885 T2886 det a,substrate
R1911 T2813 T2815 det a,study
R1912 T2886 T2884 attr substrate,is
R1913 T2887 T2886 prep for,substrate
R1914 T2888 T2889 amod direct,repair
R1915 T2814 T2815 amod recent,study
R1916 T2889 T2887 pobj repair,for
R1917 T2815 T2816 nsubj study,demonstrated
R1918 T2816 T2816 ROOT demonstrated,demonstrated
R1919 T2890 T2889 prep by,repair
R1920 T2817 T2820 mark that,is
R1921 T2891 T2892 compound O6-methylguanine-DNA,methyltransferase
R1922 T2892 T2890 pobj methyltransferase,by
R1923 T2893 T2894 punct (,MGMT
R1924 T2818 T2819 amod TMZ-induced,autophagy
R1925 T2894 T2892 appos MGMT,methyltransferase
R1926 T2895 T2884 punct ),is
R1927 T2819 T2820 nsubj autophagy,is
R1928 T2896 T2899 punct (,al.
R1929 T2897 T2899 compound Pollack,al.
R1930 T2898 T2899 nmod et,al.
R1931 T2820 T2816 ccomp is,demonstrated
R1932 T2899 T2905 compound al.,al.
R1933 T2900 T2899 punct ",",al.
R1934 T2901 T2899 npadvmod 2006,al.
R1935 T2821 T2820 acomp pro-survival,is
R1936 T2902 T2899 punct ;,al.
R1937 T2903 T2905 compound Hegi,al.
R1938 T2904 T2905 compound et,al.
R1939 T2822 T2820 punct ",",is
R1940 T2905 T2905 ROOT al.,al.
R1941 T2906 T2905 punct ",",al.
R1942 T2823 T2820 cc and,is
R1943 T2824 T2825 aux may,block
R1944 T2907 T2905 npadvmod 2008,al.
R1945 T2908 T2905 punct ;,al.
R1946 T2825 T2820 conj block,is
R1947 T2909 T2911 compound Fukushima,al.
R1948 T2910 T2911 nmod et,al.
R1949 T2911 T2905 conj al.,al.
R1950 T2826 T2828 det the,apoptosis
R1951 T2912 T2911 punct ",",al.
R1952 T2913 T2911 npadvmod 2009,al.
R1953 T2827 T2828 amod eventual,apoptosis
R1954 T2914 T2917 punct ;,al.
R1955 T2915 T2917 compound Zhang,al.
R1956 T2916 T2917 nmod et,al.
R1957 T2917 T2884 attr al.,is
R1958 T2918 T2919 punct ",",2012b
R1959 T2828 T2825 dobj apoptosis,block
R1960 T2919 T2917 amod 2012b,al.
R1961 T2920 T2919 punct ),2012b
R1962 T2921 T2884 punct .,is
R1963 T2922 T2927 prep Without,initiates
R1964 T2923 T2924 compound MGMT,repair
R1965 T2829 T2825 prep in,block
R1966 T2924 T2922 pobj repair,Without
R1967 T2925 T2927 punct ",",initiates
R1968 T2926 T2927 nsubj O6-methylguanine,initiates
R1969 T2927 T2927 ROOT initiates,initiates
R1970 T2830 T2831 compound GBM,cells
R1971 T2928 T2927 dobj activation,initiates
R1972 T2929 T2928 prep of,activation
R1973 T2930 T2929 pobj mismatch,of
R1974 T2931 T2928 conj repair-deficient,activation
R1975 T2831 T2829 pobj cells,in
R1976 T2932 T2931 punct (,repair-deficient
R1977 T2933 T2935 nmod MMR,proteins
R1978 T2934 T2935 punct ),proteins
R1979 T2935 T2931 appos proteins,repair-deficient
R1980 T2832 T2835 punct (,al.
R1981 T2936 T2935 cc or,proteins
R1982 T2937 T2939 amod Rad3-related,kinase
R1983 T2833 T2835 compound Knizhnik,al.
R1984 T2938 T2939 compound protein,kinase
R1985 T2939 T2935 conj kinase,proteins
R1986 T2940 T2942 nsubj that,leads
R1987 T2834 T2835 nmod et,al.
R1988 T2941 T2942 advmod ultimately,leads
R1989 T2942 T2939 relcl leads,kinase
R1990 T2943 T2942 prep to,leads
R1991 T2835 T2825 parataxis al.,block
R1992 T2944 T2946 amod apoptotic,death
R1993 T2945 T2946 compound cell,death
R1994 T2946 T2943 pobj death,to
R1995 T2836 T2835 punct ",",al.
R1996 T2947 T2950 punct (,al.
R1997 T2948 T2950 compound Caporali,al.
R1998 T2949 T2950 nmod et,al.
R1999 T2837 T2835 npadvmod 2013,al.
R2000 T2950 T2939 appos al.,kinase
R2001 T2951 T2950 punct ",",al.
R2002 T2952 T2950 npadvmod 2004,al.
R2003 T2838 T2835 punct ),al.
R2004 T2953 T2927 punct ;,initiates
R2005 T2839 T2816 punct .,demonstrated
R2006 T2954 T2927 conj Wang,initiates
R2007 T2955 T2954 cc and,Wang
R2008 T2956 T2954 conj Edelmann,Wang
R2009 T2957 T2956 punct ",",Edelmann
R2010 T2840 T2847 advmod Also,participates
R2011 T2841 T2847 punct ",",participates
R2012 T2842 T2847 nsubj MAPO2,participates
R2013 T2958 T2954 npadvmod 2006,Wang
R2014 T2959 T2954 punct ;,Wang
R2015 T2843 T2842 punct (,MAPO2
R2016 T2960 T2962 compound Roos,al.
R2017 T2961 T2962 nmod et,al.
R2018 T2844 T2842 appos C1orf201,MAPO2
R2019 T2962 T2954 conj al.,Wang
R2020 T2963 T2962 punct ",",al.
R2021 T2964 T2962 npadvmod 2007,al.
R2022 T2845 T2842 punct ),MAPO2
R2023 T2965 T2962 punct ),al.
R2024 T2966 T2927 punct .,initiates
R2025 T2967 T2968 compound High,expression
R2026 T2968 T2975 nsubj expression,contributes
R2027 T2846 T2847 nsubj gene,participates
R2028 T2969 T2968 prep of,expression
R2029 T2970 T2969 pobj MGMT,of
R2030 T2971 T2970 cc or,MGMT
R2031 T2847 T2847 ROOT participates,participates
R2032 T2972 T2968 conj loss,expression
R2033 T2973 T2972 prep of,loss
R2034 T2974 T2973 pobj MMR,of
R2035 T2848 T2847 prep in,participates
R2036 T2975 T2999 ccomp contributes,al.
R2037 T2976 T2975 advmod significantly,contributes
R2038 T2977 T2975 prep to,contributes
R2039 T2849 T2852 det the,apoptosis
R2040 T2978 T2979 compound TMZ,resistance
R2041 T2979 T2977 pobj resistance,to
R2042 T2980 T2975 prep in,contributes
R2043 T2850 T2852 amod O6-methylguanine,apoptosis
R2044 T2981 T2983 amod many,cases
R2045 T2982 T2983 amod clinical,cases
R2046 T2851 T2852 amod lesion-induced,apoptosis
R2047 T2983 T2980 pobj cases,in
R2048 T2984 T2987 punct (,al.
R2049 T2985 T2987 compound Pollack,al.
R2050 T2852 T2848 pobj apoptosis,in
R2051 T2986 T2987 nmod et,al.
R2052 T2853 T2856 punct (,al.
R2053 T2854 T2856 nmod Fujikane,al.
R2054 T2987 T2975 advcl al.,contributes
R2055 T2988 T2987 punct ",",al.
R2056 T2855 T2856 nmod et,al.
R2057 T2989 T2987 npadvmod 2006,al.
R2058 T2990 T2999 punct ;,al.
R2059 T2991 T2993 compound Hegi,al.
R2060 T2992 T2993 nmod et,al.
R2061 T2856 T2852 appos al.,apoptosis
R2062 T2993 T2999 ccomp al.,al.
R2063 T2994 T2993 punct ",",al.
R2064 T2857 T2856 punct ",",al.
R2065 T2995 T2993 npadvmod 2008,al.
R2066 T2858 T2856 npadvmod 2012,al.
R2067 T2996 T2999 punct ;,al.
R2068 T2997 T2999 compound Sarkaria,al.
R2069 T2998 T2999 nmod et,al.
R2070 T2859 T2856 punct ),al.
R2071 T2999 T2999 ROOT al.,al.
R2072 T3000 T2999 punct ",",al.
R2073 T3001 T2999 npadvmod 2008,al.
R2074 T2860 T2847 punct .,participates
R2075 T3002 T2999 punct ),al.
R2076 T3003 T2999 punct .,al.
R2077 T3004 T3005 det The,initiation
R2078 T3005 T3009 nsubj initiation,fails
R2079 T3055 T3057 compound MGMT,expression
R2080 T3006 T3005 prep of,initiation
R2081 T3007 T3008 amod apoptotic,signaling
R2082 T3008 T3006 pobj signaling,of
R2083 T3009 T3009 ROOT fails,fails
R2084 T3010 T3009 prep in,fails
R2085 T3056 T3057 compound protein,expression
R2086 T3011 T3012 det the,absence
R2087 T3012 T3010 pobj absence,in
R2088 T3013 T3012 prep of,absence
R2089 T3057 T3054 dobj expression,blocks
R2090 T3014 T3016 det the,system
R2091 T3015 T3016 compound MMR,system
R2092 T3016 T3013 pobj system,of
R2093 T3058 T3059 punct ",",prolongs
R2094 T3017 T3009 punct .,fails
R2095 T3018 T3023 nsubjpass Sensitivity,associated
R2096 T3019 T3018 prep to,Sensitivity
R2097 T3059 T3059 ROOT prolongs,prolongs
R2098 T3020 T3019 pobj TMZ,to
R2099 T3060 T3062 compound cancer,survival
R2100 T3061 T3062 compound patient,survival
R2101 T3021 T3023 auxpass is,associated
R2102 T3022 T3023 advmod significantly,associated
R2103 T3062 T3059 dobj survival,prolongs
R2104 T3023 T3023 ROOT associated,associated
R2105 T3024 T3023 prep with,associated
R2106 T3025 T3027 det the,status
R2107 T3026 T3027 amod methylation,status
R2108 T3027 T3024 pobj status,with
R2109 T3028 T3027 prep of,status
R2110 T3063 T3059 punct .,prolongs
R2111 T3029 T3031 compound MGMT,promoter
R2112 T3030 T3031 compound gene,promoter
R2113 T3031 T3028 pobj promoter,of
R2114 T3064 T3068 advmod Intriguingly,reduces
R2115 T3032 T3027 prep in,status
R2116 T3033 T3032 pobj cells,in
R2117 T3065 T3068 punct ",",reduces
R2118 T3034 T3033 acl committed,cells
R2119 T3035 T3034 prep to,committed
R2120 T3036 T3035 pobj differentiation,to
R2121 T3066 T3067 amod overexpressed,microRNA-21
R2122 T3037 T3040 punct (,al.
R2123 T3038 T3040 compound Villalva,al.
R2124 T3039 T3040 nmod et,al.
R2125 T3067 T3068 nsubj microRNA-21,reduces
R2126 T3040 T3027 appos al.,status
R2127 T3041 T3040 punct ",",al.
R2128 T3042 T3040 npadvmod 2012,al.
R2129 T3068 T3068 ROOT reduces,reduces
R2130 T3043 T3023 punct ),associated
R2131 T3044 T3023 punct .,associated
R2132 T3045 T3046 det An,increase
R2133 T3069 T3071 nmod Bax/Bcl,ratio
R2134 T3046 T3059 nsubj increase,prolongs
R2135 T3047 T3046 prep in,increase
R2136 T3048 T3051 compound MGMT,methylation
R2137 T3070 T3069 nummod -2,Bax/Bcl
R2138 T3049 T3050 compound gene,promoter
R2139 T3050 T3051 compound promoter,methylation
R2140 T3051 T3047 pobj methylation,in
R2141 T3071 T3068 dobj ratio,reduces
R2142 T3052 T3051 punct ",",methylation
R2143 T3053 T3054 nsubj which,blocks
R2144 T3054 T3051 relcl blocks,methylation
R2145 T3072 T3071 cc and,ratio
R2146 T3073 T3074 amod caspase-3,activity
R2147 T3074 T3071 conj activity,ratio
R2148 T3152 T3149 pobj target,as
R2149 T3153 T3152 prep for,target
R2150 T3075 T3068 punct ",",reduces
R2151 T3154 T3156 amod high-grade,tumors
R2152 T3155 T3156 compound brain,tumors
R2153 T3076 T3077 advmod thereby,blocking
R2154 T3156 T3153 pobj tumors,for
R2155 T3157 T3148 punct .,considered
R2156 T3158 T3162 det The,enzyme
R2157 T3159 T3162 amod base,enzyme
R2158 T3160 T3162 compound excision,enzyme
R2159 T3161 T3162 compound repair,enzyme
R2160 T3162 T3178 nsubj enzyme,participates
R2161 T3077 T3068 advcl blocking,reduces
R2162 T3163 T3162 amod alkylpurine-DNA-N-glycosylase,enzyme
R2163 T3164 T3165 punct (,APNG
R2164 T3165 T3163 appos APNG,alkylpurine-DNA-N-glycosylase
R2165 T3078 T3079 amod TMZ-induced,apoptosis
R2166 T3166 T3165 punct ),APNG
R2167 T3167 T3163 punct ",",alkylpurine-DNA-N-glycosylase
R2168 T3079 T3077 dobj apoptosis,blocking
R2169 T3168 T3169 nsubj which,repairs
R2170 T3080 T3083 punct (,al.
R2171 T3169 T3163 relcl repairs,alkylpurine-DNA-N-glycosylase
R2172 T3170 T3172 det the,lesions
R2173 T3081 T3083 compound Shi,al.
R2174 T3171 T3172 amod cytotoxic,lesions
R2175 T3172 T3169 dobj lesions,repairs
R2176 T3173 T3169 advmod N3-methyladenine,repairs
R2177 T3082 T3083 nmod et,al.
R2178 T3174 T3173 cc and,N3-methyladenine
R2179 T3083 T3083 ROOT al.,al.
R2180 T3175 T3173 conj N7-methylguanine,N3-methyladenine
R2181 T3176 T3178 punct ",",participates
R2182 T3084 T3083 punct ",",al.
R2183 T3177 T3178 advmod also,participates
R2184 T3178 T3178 ROOT participates,participates
R2185 T3179 T3178 prep in,participates
R2186 T3085 T3083 npadvmod 2010,al.
R2187 T3180 T3182 det the,resistance
R2188 T3181 T3182 compound TMZ,resistance
R2189 T3182 T3179 pobj resistance,in
R2190 T3086 T3083 punct ),al.
R2191 T3183 T3186 punct (,al.
R2192 T3184 T3186 nmod Agnihotri,al.
R2193 T3185 T3186 nmod et,al.
R2194 T3087 T3083 punct .,al.
R2195 T3186 T3178 dep al.,participates
R2196 T3187 T3186 punct ",",al.
R2197 T3188 T3186 npadvmod 2012,al.
R2198 T3088 T3090 nsubjpass MicroRNA-21,considered
R2199 T3189 T3186 punct ),al.
R2200 T3190 T3178 punct .,participates
R2201 T3191 T3191 ROOT Upregulation,Upregulation
R2202 T3089 T3090 auxpass is,considered
R2203 T3192 T3191 prep of,Upregulation
R2204 T3193 T3196 amod mitochondrial,coupling
R2205 T3090 T3090 ROOT considered,considered
R2206 T3194 T3195 amod respiratory,chain
R2207 T3195 T3196 compound chain,coupling
R2208 T3196 T3192 pobj coupling,of
R2209 T3091 T3090 prep as,considered
R2210 T3092 T3094 det a,factor
R2211 T3197 T3198 aux to,suppress
R2212 T3198 T3191 advcl suppress,Upregulation
R2213 T3093 T3094 amod pro-survival,factor
R2214 T3199 T3200 det the,production
R2215 T3200 T3198 dobj production,suppress
R2216 T3094 T3091 pobj factor,as
R2217 T3201 T3200 prep of,production
R2218 T3202 T3204 amod reactive,species
R2219 T3203 T3204 compound oxygen,species
R2220 T3095 T3094 prep for,factor
R2221 T3204 T3201 pobj species,of
R2222 T3205 T3208 punct (,regulated
R2223 T3206 T3208 dep ROS,regulated
R2224 T3096 T3097 compound cancer,cells
R2225 T3207 T3208 punct ),regulated
R2226 T3097 T3095 pobj cells,for
R2227 T3208 T3198 advcl regulated,suppress
R2228 T3098 T3101 punct (,al.
R2229 T3209 T3208 agent by,regulated
R2230 T3210 T3212 compound cytochrome,oxidase
R2231 T3211 T3212 compound c,oxidase
R2232 T3099 T3101 compound Li,al.
R2233 T3212 T3209 pobj oxidase,by
R2234 T3213 T3208 punct contributes,regulated
R2235 T3100 T3101 nmod et,al.
R2236 T3214 T3213 prep in,contributes
R2237 T3215 T3214 pobj part,in
R2238 T3216 T3215 prep to,part
R2239 T3101 T3094 appos al.,factor
R2240 T3217 T3218 compound TMZ,resistance
R2241 T3218 T3216 pobj resistance,to
R2242 T3219 T3218 prep in,resistance
R2243 T3102 T3101 punct ",",al.
R2244 T3220 T3219 pobj gliomas,in
R2245 T3221 T3224 punct (,al.
R2246 T3222 T3224 compound Oliva,al.
R2247 T3103 T3101 npadvmod 2012,al.
R2248 T3223 T3224 nmod et,al.
R2249 T3224 T3208 dep al.,regulated
R2250 T3104 T3101 punct ),al.
R2251 T3225 T3224 punct ",",al.
R2252 T3226 T3224 npadvmod 2011,al.
R2253 T3227 T3224 punct ),al.
R2254 T3105 T3090 punct .,considered
R2255 T3228 T3191 punct .,Upregulation
R2256 T3229 T3235 nsubjpass Reversal,achieved
R2257 T3230 T3229 prep of,Reversal
R2258 T3231 T3230 pobj TMZ,of
R2259 T3232 T3235 nsubjpass resistance,achieved
R2260 T3233 T3235 aux may,achieved
R2261 T3106 T3107 nsubj Integrins,play
R2262 T3234 T3235 auxpass be,achieved
R2263 T3235 T3235 ROOT achieved,achieved
R2264 T3236 T3235 agent by,achieved
R2265 T3107 T3107 ROOT play,play
R2266 T3237 T3238 compound MGMT,pseudosubstrates
R2267 T3238 T3236 pobj pseudosubstrates,by
R2268 T3239 T3238 punct ",",pseudosubstrates
R2269 T3108 T3109 det a,role
R2270 T3240 T3238 conj O6-benzylguanine,pseudosubstrates
R2271 T3241 T3240 cc and,O6-benzylguanine
R2272 T3109 T3107 dobj role,play
R2273 T3242 T3240 conj lomeguatrib,O6-benzylguanine
R2274 T3243 T3244 aux to,sensitize
R2275 T3244 T3235 xcomp sensitize,achieved
R2276 T3245 T3244 dobj tumors,sensitize
R2277 T3110 T3109 prep in,role
R2278 T3246 T3244 prep to,sensitize
R2279 T3111 T3112 det the,resistance
R2280 T3247 T3246 pobj TMZ,to
R2281 T3112 T3110 pobj resistance,in
R2282 T3113 T3112 prep of,resistance
R2283 T3248 T3251 punct (,al.
R2284 T3114 T3115 amod advanced,cancers
R2285 T3115 T3113 pobj cancers,of
R2286 T3249 T3251 compound Zhang,al.
R2287 T3250 T3251 nmod et,al.
R2288 T3116 T3117 aux to,radiotherapy
R2289 T3251 T3246 parataxis al.,to
R2290 T3252 T3251 punct ",",al.
R2291 T3253 T3251 amod 2012b,al.
R2292 T3117 T3115 relcl radiotherapy,cancers
R2293 T3254 T3251 punct ),al.
R2294 T3255 T3235 punct .,achieved
R2295 T3118 T3117 cc and,radiotherapy
R2296 T3119 T3117 conj chemotherapy,radiotherapy
R2297 T3256 T3261 nsubj Methoxyamine-blocker,contributes
R2298 T3120 T3107 punct .,play
R2299 T3257 T3256 prep of,Methoxyamine-blocker
R2300 T3258 T3260 compound base,repair
R2301 T3259 T3260 compound excision,repair
R2302 T3121 T3122 amod α5β1,integrin
R2303 T3260 T3257 pobj repair,of
R2304 T3261 T3261 ROOT contributes,contributes
R2305 T3262 T3261 advmod significantly,contributes
R2306 T3122 T3124 nsubj integrin,regulates
R2307 T3263 T3261 prep to,contributes
R2308 T3264 T3265 compound TMZ,cytotoxicity
R2309 T3265 T3263 pobj cytotoxicity,to
R2310 T3266 T3271 advmod particularly,repaired
R2311 T3267 T3271 advmod when,repaired
R2312 T3268 T3269 amod O6-methylguanine,adducts
R2313 T3123 T3124 advmod negatively,regulates
R2314 T3269 T3271 nsubjpass adducts,repaired
R2315 T3270 T3271 auxpass are,repaired
R2316 T3271 T3261 advcl repaired,contributes
R2317 T3124 T3124 ROOT regulates,regulates
R2318 T3272 T3271 cc or,repaired
R2319 T3273 T3271 conj tolerated,repaired
R2320 T3274 T3283 punct (,al.
R2321 T3275 T3277 nmod Goellner,al.
R2322 T3125 T3124 dobj p53,regulates
R2323 T3276 T3277 nmod et,al.
R2324 T3277 T3283 ccomp al.,al.
R2325 T3126 T3125 acl signaling,p53
R2326 T3278 T3277 punct ",",al.
R2327 T3279 T3277 npadvmod 2011,al.
R2328 T3280 T3283 punct ;,al.
R2329 T3127 T3124 punct ",",regulates
R2330 T3281 T3283 compound Zhang,al.
R2331 T3282 T3283 nmod et,al.
R2332 T3283 T3283 ROOT al.,al.
R2333 T3128 T3124 cc and,regulates
R2334 T3284 T3285 punct ",",2012b
R2335 T3285 T3283 amod 2012b,al.
R2336 T3286 T3285 punct ),2012b
R2337 T3129 T3130 det the,event
R2338 T3287 T3261 punct .,contributes
R2339 T3130 T3131 nsubj event,induces
R2340 T3288 T3289 amod Dual,targeting
R2341 T3131 T3124 conj induces,regulates
R2342 T3132 T3134 amod glioma,resistance
R2343 T3289 T3301 nsubj targeting,reverse
R2344 T3290 T3289 prep of,targeting
R2345 T3291 T3293 compound base,repair
R2346 T3133 T3134 compound cell,resistance
R2347 T3292 T3293 compound excision,repair
R2348 T3293 T3290 pobj repair,of
R2349 T3134 T3131 dobj resistance,induces
R2350 T3294 T3293 cc and,repair
R2351 T3295 T3299 nmod NAD,biosynthesis
R2352 T3296 T3297 punct (,+
R2353 T3135 T3134 prep to,resistance
R2354 T3297 T3295 parataxis +,NAD
R2355 T3298 T3299 punct ),biosynthesis
R2356 T3299 T3293 conj biosynthesis,repair
R2357 T3300 T3301 aux may,reverse
R2358 T3136 T3135 pobj TMZ,to
R2359 T3301 T3301 ROOT reverse,reverse
R2360 T3302 T3303 compound TMZ,resistance
R2361 T3303 T3301 dobj resistance,reverse
R2362 T3304 T3301 prep in,reverse
R2363 T3305 T3304 pobj patients,in
R2364 T3306 T3305 prep with,patients
R2365 T3137 T3140 punct (,al.
R2366 T3307 T3310 amod resistant,GBM
R2367 T3308 T3307 cc and,resistant
R2368 T3309 T3307 conj recurrent,resistant
R2369 T3138 T3140 nmod Janouskova,al.
R2370 T3310 T3306 pobj GBM,with
R2371 T3311 T3310 punct (,GBM
R2372 T3312 T3314 nmod Goellner,al.
R2373 T3139 T3140 nmod et,al.
R2374 T3313 T3314 nmod et,al.
R2375 T3314 T3301 dep al.,reverse
R2376 T3140 T3134 appos al.,resistance
R2377 T3141 T3140 punct ",",al.
R2378 T3315 T3314 punct ",",al.
R2379 T3142 T3140 npadvmod 2012,al.
R2380 T3316 T3314 npadvmod 2011,al.
R2381 T3317 T3314 punct ),al.
R2382 T3318 T3301 punct .,reverse
R2383 T3319 T3337 nsubj Interferon-β,increase
R2384 T3143 T3131 punct ),induces
R2385 T3320 T3321 punct (,IFN-β
R2386 T3321 T3319 appos IFN-β,Interferon-β
R2387 T3322 T3321 punct ),IFN-β
R2388 T3144 T3124 punct .,regulates
R2389 T3323 T3319 punct ",",Interferon-β
R2390 T3324 T3319 appos levetiracetam,Interferon-β
R2391 T3325 T3326 punct (,LEV
R2392 T3145 T3146 amod α5β1,integrin
R2393 T3326 T3324 appos LEV,levetiracetam
R2394 T3327 T3326 punct ),LEV
R2395 T3328 T3324 punct ",",levetiracetam
R2396 T3146 T3148 nsubjpass integrin,considered
R2397 T3329 T3324 conj resveratrol,levetiracetam
R2398 T3330 T3329 punct ",",resveratrol
R2399 T3331 T3329 cc and,resveratrol
R2400 T3147 T3148 auxpass is,considered
R2401 T3332 T3333 amod valproic,acid
R2402 T3333 T3329 conj acid,resveratrol
R2403 T3334 T3333 punct (,acid
R2404 T3335 T3337 nsubj VAP,increase
R2405 T3148 T3148 ROOT considered,considered
R2406 T3336 T3337 punct ),increase
R2407 T3337 T3337 ROOT increase,increase
R2408 T3149 T3148 prep as,considered
R2409 T3338 T3339 det the,sensitivity
R2410 T3339 T3337 dobj sensitivity,increase
R2411 T3340 T3339 prep of,sensitivity
R2412 T3341 T3340 pobj TMZ,of
R2413 T3342 T3337 prep through,increase
R2414 T3150 T3152 det a,target
R2415 T3343 T3342 pobj MGMT-dependent,through
R2416 T3344 T3343 cc or,MGMT-dependent
R2417 T3345 T3346 punct -,independent
R2418 T3151 T3152 amod therapeutic,target
R2419 T3443 T3442 prep in,failure
R2420 T3346 T3347 amod independent,mechanisms
R2421 T3347 T3343 conj mechanisms,MGMT-dependent
R2422 T3348 T3347 punct (,mechanisms
R2423 T3444 T3445 compound TMZ,treatment
R2424 T3349 T3351 compound Nakada,al.
R2425 T3350 T3351 nmod et,al.
R2426 T3351 T3347 appos al.,mechanisms
R2427 T3445 T3443 pobj treatment,in
R2428 T3352 T3351 punct ",",al.
R2429 T3353 T3351 npadvmod 2012,al.
R2430 T3446 T3437 punct .,are
R2431 T3354 T3347 punct ),mechanisms
R2432 T3447 T3448 det The,concept
R2433 T3355 T3337 punct .,increase
R2434 T3356 T3362 nsubj Resveratrol,reverses
R2435 T3357 T3356 punct ",",Resveratrol
R2436 T3448 T3478 nsubjpass concept,al.
R2437 T3358 T3360 det a,polyphenol
R2438 T3359 T3360 amod natural,polyphenol
R2439 T3360 T3356 appos polyphenol,Resveratrol
R2440 T3361 T3356 punct ",",Resveratrol
R2441 T3449 T3448 prep of,concept
R2442 T3362 T3362 ROOT reverses,reverses
R2443 T3363 T3364 compound TMZ,resistance
R2444 T3450 T3452 compound cancer,cell
R2445 T3364 T3362 dobj resistance,reverses
R2446 T3365 T3362 prep via,reverses
R2447 T3366 T3368 det an,mechanism
R2448 T3451 T3452 compound stem,cell
R2449 T3367 T3368 amod NF-κB-dependent,mechanism
R2450 T3368 T3365 pobj mechanism,via
R2451 T3369 T3368 punct (,mechanism
R2452 T3452 T3453 compound cell,survival
R2453 T3370 T3372 compound Huang,al.
R2454 T3371 T3372 nmod et,al.
R2455 T3453 T3449 pobj survival,of
R2456 T3372 T3368 appos al.,mechanism
R2457 T3373 T3372 punct ",",al.
R2458 T3374 T3372 npadvmod 2012,al.
R2459 T3454 T3448 prep from,concept
R2460 T3375 T3368 punct ),mechanism
R2461 T3376 T3362 punct .,reverses
R2462 T3377 T3378 nummod STAT3,inhibitor
R2463 T3378 T3384 nmod inhibitor,efficacy
R2464 T3379 T3378 cc or,inhibitor
R2465 T3380 T3382 nummod STAT3,potentiates
R2466 T3381 T3382 amod knockdown,potentiates
R2467 T3455 T3454 pobj treatment,from
R2468 T3382 T3378 conj potentiates,inhibitor
R2469 T3383 T3384 compound TMZ,efficacy
R2470 T3384 T3384 ROOT efficacy,efficacy
R2471 T3456 T3448 prep with,concept
R2472 T3385 T3384 prep in,efficacy
R2473 T3386 T3389 amod resistant,lines
R2474 T3457 T3456 pobj TMZ,with
R2475 T3387 T3389 nmod GBM,lines
R2476 T3388 T3389 compound cell,lines
R2477 T3389 T3385 pobj lines,in
R2478 T3458 T3457 cc and,TMZ
R2479 T3390 T3389 punct (,lines
R2480 T3391 T3393 compound Kohsaka,al.
R2481 T3392 T3393 nmod et,al.
R2482 T3459 T3461 amod other,drugs
R2483 T3393 T3389 appos al.,lines
R2484 T3460 T3461 amod chemotherapeutic,drugs
R2485 T3394 T3393 punct ",",al.
R2486 T3461 T3457 conj drugs,TMZ
R2487 T3395 T3393 npadvmod 2012,al.
R2488 T3396 T3389 punct ),lines
R2489 T3462 T3463 aux has,been
R2490 T3397 T3384 punct .,efficacy
R2491 T3398 T3399 compound Intratumoral,hypoxia
R2492 T3399 T3400 nsubj hypoxia,is
R2493 T3463 T3478 auxpass been,al.
R2494 T3400 T3400 ROOT is,is
R2495 T3401 T3400 acomp common,is
R2496 T3464 T3465 advmod more,complicated
R2497 T3402 T3400 prep in,is
R2498 T3403 T3402 pobj GBMs,in
R2499 T3465 T3478 ccomp complicated,al.
R2500 T3404 T3400 cc and,is
R2501 T3405 T3407 aux may,associated
R2502 T3406 T3407 auxpass be,associated
R2503 T3466 T3468 mark than,thought
R2504 T3407 T3400 conj associated,is
R2505 T3408 T3407 prep with,associated
R2506 T3409 T3410 det the,development
R2507 T3467 T3468 advmod previously,thought
R2508 T3410 T3408 pobj development,with
R2509 T3411 T3410 prep of,development
R2510 T3412 T3413 compound TMZ,resistance
R2511 T3413 T3411 pobj resistance,of
R2512 T3414 T3400 punct .,is
R2513 T3415 T3416 amod Induced,hyperoxia
R2514 T3468 T3465 advcl thought,complicated
R2515 T3416 T3419 nsubjpass hyperoxia,utilized
R2516 T3417 T3419 aux can,utilized
R2517 T3418 T3419 auxpass be,utilized
R2518 T3419 T3419 ROOT utilized,utilized
R2519 T3469 T3465 punct (,complicated
R2520 T3420 T3421 aux to,reverse
R2521 T3421 T3419 xcomp reverse,utilized
R2522 T3422 T3423 compound TMZ,resistance
R2523 T3470 T3472 nmod Beier,al.
R2524 T3423 T3421 dobj resistance,reverse
R2525 T3424 T3421 prep in,reverse
R2526 T3425 T3424 pobj GBMs,in
R2527 T3471 T3472 nmod et,al.
R2528 T3472 T3465 punct al.,complicated
R2529 T3426 T3429 punct (,al.
R2530 T3473 T3472 punct ",",al.
R2531 T3427 T3429 nmod Sun,al.
R2532 T3428 T3429 nmod et,al.
R2533 T3429 T3419 parataxis al.,utilized
R2534 T3474 T3472 npadvmod 2011,al.
R2535 T3430 T3429 punct ",",al.
R2536 T3431 T3429 npadvmod 2012,al.
R2537 T3475 T3478 punct ;,al.
R2538 T3432 T3429 punct ),al.
R2539 T3433 T3419 punct .,utilized
R2540 T3434 T3436 compound Cancer,cells
R2541 T3476 T3478 compound Chen,al.
R2542 T3435 T3436 compound stem,cells
R2543 T3436 T3437 nsubj cells,are
R2544 T3437 T3437 ROOT are,are
R2545 T3477 T3478 compound et,al.
R2546 T3478 T3478 ROOT al.,al.
R2547 T3479 T3478 punct ",",al.
R2548 T3438 T3437 advmod probably,are
R2549 T3439 T3440 det the,key
R2550 T3480 T3478 npadvmod 2012,al.
R2551 T3440 T3437 attr key,are
R2552 T3441 T3440 prep to,key
R2553 T3481 T3478 punct ),al.
R2554 T3442 T3441 pobj failure,to
R2555 T3482 T3478 punct .,al.
R2556 T3483 T3486 amod CD133-positive,cells
R2557 T3484 T3485 compound cancer,stem
R2558 T3485 T3486 compound stem,cells
R2559 T3488 T3488 ROOT expressed,expressed
R2560 T3489 T3488 prep in,expressed
R2561 T3490 T3493 det both,cells
R2562 T3491 T3493 amod normal,cells
R2563 T3486 T3488 nsubjpass cells,expressed
R2564 T3492 T3493 compound stem,cells
R2565 T3493 T3489 pobj cells,in
R2566 T3494 T3493 cc and,cells
R2567 T3495 T3496 compound cancer,stem
R2568 T3487 T3488 auxpass are,expressed
R2569 T3496 T3497 compound stem,cells
R2570 T3497 T3493 conj cells,cells
R2571 T3498 T3488 punct (,expressed
R2572 T3499 T3488 dep Donovan,expressed
R2573 T3500 T3499 cc and,Donovan
R2574 T3501 T3499 conj Pilkington,Donovan
R2575 T3502 T3501 punct ",",Pilkington
R2576 T3503 T3501 npadvmod 2012,Pilkington
R2577 T3504 T3501 punct ),Pilkington
R2578 T3505 T3488 punct .,expressed
R2579 T3506 T3529 advmod However,established
R2580 T3507 T3529 punct ",",established
R2581 T3508 T3509 det the,role
R2582 T3509 T3529 nsubjpass role,established
R2583 T3510 T3509 prep of,role
R2584 T3511 T3510 pobj CD133,of
R2585 T3512 T3509 prep as,role
R2586 T3513 T3514 det a,marker
R2587 T3514 T3512 pobj marker,as
R2588 T3515 T3514 prep for,marker
R2589 T3516 T3519 amod glioma,cells
R2590 T3517 T3518 compound cancer,stem
R2591 T3518 T3519 compound stem,cells
R2592 T3519 T3515 pobj cells,for
R2593 T3520 T3519 amod relative,cells
R2594 T3521 T3520 prep to,relative
R2595 T3522 T3524 poss its,function
R2596 T3523 T3524 amod biological,function
R2597 T3524 T3521 pobj function,to
R2598 T3525 T3529 aux has,established
R2599 T3526 T3529 advmod yet,established
R2600 T3527 T3529 aux to,established
R2601 T3528 T3529 auxpass be,established
R2602 T3529 T3529 ROOT established,established
R2603 T3530 T3529 punct .,established
R3890 T5791 T5790 punct ",",al.
R3894 T5771 T5779 advmod Recently,shown
R3895 T5772 T5779 punct ",",shown
R3896 T5773 T5775 nmod tumor,p53
R3897 T5774 T5775 compound suppressors,p53
R3898 T5775 T5779 nsubjpass p53,shown
R3899 T5776 T5775 cc and,p53
R3900 T5777 T5775 conj WWOX,p53
R3901 T5792 T5790 npadvmod 2012,al.
R3902 T5778 T5779 auxpass were,shown
R3903 T5779 T5779 ROOT shown,shown
R3904 T5780 T5781 aux to,regulate
R3905 T5793 T5783 punct ),apoptosis
R3906 T5781 T5779 xcomp regulate,shown
R3907 T5782 T5783 det the,apoptosis
R3908 T5783 T5781 dobj apoptosis,regulate
R3909 T5794 T5779 punct .,shown
R3910 T5784 T5783 prep of,apoptosis
R3911 T5785 T5786 compound glioblastoma,cells
R3912 T5786 T5784 pobj cells,of
R3913 T5787 T5790 punct (,al.
R3914 T5795 T5797 nmod WW,oxidoreductase
R3915 T5788 T5790 compound Chiang,al.
R3916 T5789 T5790 nmod et,al.
R3917 T5790 T5783 appos al.,apoptosis
R3918 T5796 T5797 amod domain-containing,oxidoreductase
R3919 T5797 T5809 nsubjpass oxidoreductase,encoded
R3920 T5798 T5797 punct ",",oxidoreductase
R3921 T5835 T5834 appos FRA16D,site
R3922 T5799 T5797 acl known,oxidoreductase
R3923 T5836 T5820 punct .,located
R3924 T5837 T5840 det The,protein
R3925 T5800 T5799 prep as,known
R3926 T5838 T5840 amod full-length,protein
R3927 T5839 T5840 compound WWOX,protein
R3928 T5840 T5842 nsubjpass protein,composed
R3929 T5801 T5800 pobj WWOX,as
R3930 T5841 T5842 auxpass is,composed
R3931 T5842 T5842 ROOT composed,composed
R3932 T5843 T5842 prep of,composed
R3933 T5802 T5809 punct ",",encoded
R3934 T5844 T5847 nummod two,domains
R3935 T5845 T5847 amod N-terminal,domains
R3936 T5846 T5847 compound WW,domains
R3937 T5803 T5809 prep FOR,encoded
R3938 T5847 T5843 pobj domains,of
R3939 T5848 T5847 punct ",",domains
R3940 T5849 T5853 det a,dehydrogenase/reductase
R3941 T5804 T5803 punct ",",FOR
R3942 T5850 T5853 amod C-terminal,dehydrogenase/reductase
R3943 T5805 T5803 cc or,FOR
R3944 T5851 T5853 compound short-chain,dehydrogenase/reductase
R3945 T5852 T5853 compound alcohol,dehydrogenase/reductase
R3946 T5853 T5847 appos dehydrogenase/reductase,domains
R3947 T5854 T5855 punct (,SDR
R3948 T5806 T5809 nsubjpass WOX1,encoded
R3949 T5855 T5853 appos SDR,dehydrogenase/reductase
R3950 T5856 T5855 punct ),SDR
R3951 T5857 T5853 conj domain,dehydrogenase/reductase
R3952 T5807 T5809 punct ",",encoded
R3953 T5858 T5857 punct ",",domain
R3954 T5859 T5857 cc and,domain
R3955 T5860 T5864 det a,D3
R3956 T5808 T5809 auxpass is,encoded
R3957 T5861 T5864 amod proapoptotic,D3
R3958 T5862 T5863 amod C-terminal,tail
R3959 T5863 T5864 compound tail,D3
R3960 T5809 T5809 ROOT encoded,encoded
R3961 T5864 T5857 conj D3,domain
R3962 T5865 T5868 punct (,al.
R3963 T5866 T5868 compound Chang,al.
R3964 T5810 T5809 agent by,encoded
R3965 T5867 T5868 nmod et,al.
R3966 T5868 T5864 appos al.,D3
R3967 T5869 T5868 punct ",",al.
R3968 T5811 T5815 amod human,gene
R3969 T5870 T5868 appos 2001,al.
R3970 T5871 T5870 punct ",",2001
R3971 T5872 T5870 conj 2007,2001
R3972 T5812 T5811 cc or,human
R3973 T5873 T5872 punct ",",2007
R3974 T5874 T5872 conj 2010,2007
R3975 T5813 T5811 conj mouse,human
R3976 T5875 T5847 punct ;,domains
R3977 T5876 T5878 compound Aqeilan,al.
R3978 T5877 T5878 compound et,al.
R3979 T5814 T5815 compound WWOX/Wwox,gene
R3980 T5878 T5847 appos al.,domains
R3981 T5879 T5878 punct ",",al.
R3982 T5815 T5810 pobj gene,by
R3983 T5880 T5878 appos 2004,al.
R3984 T5881 T5880 punct ",",2004
R3985 T5882 T5880 conj 2007,2004
R3986 T5816 T5809 punct .,encoded
R3987 T5883 T5847 punct ;,domains
R3988 T5884 T5886 compound Hong,al.
R3989 T5817 T5818 det This,gene
R3990 T5885 T5886 nmod et,al.
R3991 T5886 T5847 appos al.,domains
R3992 T5887 T5886 punct ",",al.
R3993 T5818 T5820 nsubjpass gene,located
R3994 T5888 T5886 npadvmod 2007,al.
R3995 T5889 T5847 punct ;,domains
R3996 T5890 T5892 compound Salah,al.
R3997 T5819 T5820 auxpass is,located
R3998 T5891 T5892 nmod et,al.
R3999 T5892 T5847 appos al.,domains
R4000 T5893 T5892 punct ",",al.
R4001 T5820 T5820 ROOT located,located
R4002 T5894 T5892 npadvmod 2012,al.
R4003 T5895 T5847 punct ),domains
R4004 T5821 T5820 prep in,located
R4005 T5896 T5847 punct (,domains
R4006 T5897 T5847 appos Figure,domains
R4007 T5898 T5897 nummod 1,Figure
R4008 T5822 T5821 pobj chromosome,in
R4009 T5899 T5847 punct ),domains
R4010 T5900 T5842 punct .,composed
R4011 T5901 T5903 nsubj WWOX,act
R4012 T5823 T5822 nummod 16q23,chromosome
R4013 T5902 T5903 aux may,act
R4014 T5903 T5937 ccomp act,al.
R4015 T5904 T5903 prep as,act
R4016 T5905 T5907 det an,receptor
R4017 T5824 T5822 nummod .3,chromosome
R4018 T5906 T5907 amod alternative,receptor
R4019 T5907 T5904 pobj receptor,as
R4020 T5825 T5820 npadvmod 24.1,located
R4021 T5908 T5907 prep for,receptor
R4022 T5909 T5911 compound sex,hormones
R4023 T5910 T5911 compound steroid,hormones
R4024 T5911 T5908 pobj hormones,for
R4025 T5912 T5903 punct ",",act
R4026 T5913 T5917 mark since,possesses
R4027 T5826 T5825 punct ",",24.1
R4028 T5914 T5916 poss its,domain
R4029 T5915 T5916 compound SDR,domain
R4030 T5916 T5917 nsubj domain,possesses
R4031 T5827 T5828 det an,area
R4032 T5917 T5903 advcl possesses,act
R4033 T5918 T5920 det an,motif
R4034 T5919 T5920 compound NSYK,motif
R4035 T5828 T5825 npadvmod area,24.1
R4036 T5920 T5917 dobj motif,possesses
R4037 T5921 T5920 amod capable,motif
R4038 T5922 T5921 prep of,capable
R4039 T5829 T5828 acl known,area
R4040 T5923 T5922 pcomp interacting,of
R4041 T5924 T5923 prep with,interacting
R4042 T5925 T5924 pobj androgen,with
R4043 T5830 T5829 prep as,known
R4044 T5926 T5925 cc and,androgen
R4045 T5927 T5925 conj estrogen,androgen
R4046 T5928 T5931 punct (,al.
R4047 T5831 T5834 det the,site
R4048 T5929 T5931 compound Chang,al.
R4049 T5930 T5931 nmod et,al.
R4050 T5931 T5921 appos al.,capable
R4051 T5832 T5834 amod common,site
R4052 T5833 T5834 amod fragile,site
R4053 T5834 T5830 pobj site,as
R4054 T6029 T6033 nsubj Restoration,prevents
R4055 T5932 T5933 punct ",",2005a
R4056 T5933 T5931 amod 2005a,al.
R4057 T6030 T6029 prep of,Restoration
R4058 T5934 T5937 punct ;,al.
R4059 T5935 T5937 compound Su,al.
R4060 T5936 T5937 nmod et,al.
R4061 T6031 T6032 compound WWOX,gene
R4062 T5937 T5937 ROOT al.,al.
R4063 T6032 T6030 pobj gene,of
R4064 T5938 T5937 punct ",",al.
R4065 T6033 T6033 ROOT prevents,prevents
R4066 T5939 T5937 npadvmod 2012,al.
R4067 T6034 T6035 det the,growth
R4068 T5940 T5937 punct ),al.
R4069 T5941 T5937 punct .,al.
R4070 T5942 T5947 nsubjpass Expression,altered
R4071 T6035 T6033 dobj growth,prevents
R4072 T5943 T5942 prep of,Expression
R4073 T5944 T5943 pobj WWOX,of
R4074 T5945 T5947 auxpass is,altered
R4075 T5946 T5947 preconj either,altered
R4076 T5947 T6013 ccomp altered,al.
R4077 T5948 T5947 cc or,altered
R4078 T6036 T6035 prep of,growth
R4079 T5949 T5947 conj lost,altered
R4080 T6037 T6038 compound lung,cancer
R4081 T5950 T5949 prep from,lost
R4082 T6038 T6036 pobj cancer,of
R4083 T6039 T6042 punct (,al.
R4084 T5951 T5952 amod epigenetic,modification
R4085 T6040 T6042 compound Fabbri,al.
R4086 T6041 T6042 nmod et,al.
R4087 T5952 T5950 pobj modification,from
R4088 T6042 T6035 appos al.,growth
R4089 T6043 T6042 punct ",",al.
R4090 T5953 T5952 prep in,modification
R4091 T6044 T6042 npadvmod 2005,al.
R4092 T5954 T5956 amod multiple,cancers
R4093 T6045 T6035 punct ),growth
R4094 T6046 T6035 punct ",",growth
R4095 T6047 T6048 compound pancreatic,cancer
R4096 T6048 T6035 appos cancer,growth
R4097 T5955 T5956 amod malignant,cancers
R4098 T6049 T6052 punct (,al.
R4099 T5956 T5953 pobj cancers,in
R4100 T6050 T6052 compound Nakayama,al.
R4101 T6051 T6052 nmod et,al.
R4102 T5957 T5956 punct ",",cancers
R4103 T5958 T5959 amod such,as
R4104 T6052 T6035 appos al.,growth
R4105 T5959 T5956 prep as,cancers
R4106 T5960 T5963 amod non-small,carcinoma
R4107 T6053 T6052 punct ",",al.
R4108 T5961 T5962 compound cell,lung
R4109 T5962 T5963 compound lung,carcinoma
R4110 T5963 T5959 pobj carcinoma,as
R4111 T6054 T6052 npadvmod 2008,al.
R4112 T5964 T5967 punct (,al.
R4113 T5965 T5967 nmod Donati,al.
R4114 T6055 T6035 punct ),growth
R4115 T5966 T5967 nmod et,al.
R4116 T5967 T5963 advmod al.,carcinoma
R4117 T5968 T5967 punct ",",al.
R4118 T6056 T6033 punct ",",prevents
R4119 T5969 T5967 npadvmod 2007,al.
R4120 T5970 T5967 punct ),al.
R4121 T5971 T5963 punct ",",carcinoma
R4122 T5972 T5973 amod hematopoietic,malignancies
R4123 T5973 T5963 conj malignancies,carcinoma
R4124 T6057 T6033 cc and,prevents
R4125 T5974 T5963 punct (,carcinoma
R4126 T5975 T6003 poss Ishii,carcinoma
R4127 T5976 T5975 cc and,Ishii
R4128 T5977 T5975 conj Furukawa,Ishii
R4129 T6058 T6059 compound prostate,cancer
R4130 T5978 T5977 punct ",",Furukawa
R4131 T5979 T5977 npadvmod 2004,Furukawa
R4132 T5980 T5977 punct ),Furukawa
R4133 T6059 T6033 conj cancer,prevents
R4134 T5981 T5983 punct ",",carcinoma
R4135 T5982 T5983 amod gastric,carcinoma
R4136 T5983 T5975 conj carcinoma,Ishii
R4137 T6060 T6063 punct (,al.
R4138 T5984 T5983 punct (,carcinoma
R4139 T5985 T5987 amod Aqeilan,al.
R4140 T6061 T6063 nmod Hong,al.
R4141 T5986 T5987 nmod et,al.
R4142 T5987 T5983 appos al.,carcinoma
R4143 T5988 T5987 punct ",",al.
R4144 T6062 T6063 nmod et,al.
R4145 T5989 T5987 pobj 2004,al.
R4146 T5990 T5983 punct ),carcinoma
R4147 T5991 T5983 punct ",",carcinoma
R4148 T6063 T6059 parataxis al.,cancer
R4149 T5992 T5993 amod pancreatic,carcinoma
R4150 T5993 T5983 conj carcinoma,carcinoma
R4151 T5994 T5997 punct (,al.
R4152 T6064 T6063 punct ",",al.
R4153 T5995 T5997 nmod Kuroki,al.
R4154 T5996 T5997 nmod et,al.
R4155 T6065 T6063 npadvmod 2009,al.
R4156 T5997 T5983 appos al.,carcinoma
R4157 T5998 T5997 punct ",",al.
R4158 T5999 T5997 npadvmod 2004,al.
R4159 T6066 T6063 punct ),al.
R4160 T6000 T5983 punct ),carcinoma
R4161 T6001 T5983 punct ",",carcinoma
R4162 T6067 T6033 punct .,prevents
R4163 T6002 T6003 compound breast,carcinoma
R4164 T6003 T5963 appos carcinoma,carcinoma
R4165 T6004 T6007 punct (,al.
R4166 T6068 T6071 det The,domain
R4167 T6005 T6007 compound Guler,al.
R4168 T6006 T6007 nmod et,al.
R4169 T6007 T6003 appos al.,carcinoma
R4170 T6069 T6071 amod first,domain
R4171 T6008 T6007 punct ",",al.
R4172 T6009 T6007 npadvmod 2004,al.
R4173 T6010 T6013 punct ;,al.
R4174 T6011 T6013 compound Aqeilan,al.
R4175 T6012 T6013 compound et,al.
R4176 T6013 T6013 ROOT al.,al.
R4177 T6070 T6071 compound WW,domain
R4178 T6014 T6013 punct ",",al.
R4179 T6015 T6013 npadvmod 2007,al.
R4180 T6016 T6013 punct ),al.
R4181 T6071 T6075 nsubj domain,interact
R4182 T6017 T6013 punct ",",al.
R4183 T6018 T6013 cc and,al.
R4184 T6019 T6020 compound glioblastoma,multiforme
R4185 T6072 T6071 prep of,domain
R4186 T6020 T6013 conj multiforme,al.
R4187 T6021 T6020 punct (,multiforme
R4188 T6022 T6024 compound Kosla,al.
R4189 T6073 T6072 pobj WWOX,of
R4190 T6023 T6024 nmod et,al.
R4191 T6024 T6020 appos al.,multiforme
R4192 T6025 T6024 punct ",",al.
R4193 T6074 T6075 aux may,interact
R4194 T6026 T6024 npadvmod 2011,al.
R4195 T6027 T6020 punct ),multiforme
R4196 T6075 T6075 ROOT interact,interact
R4197 T6028 T6013 punct .,al.
R4198 T6076 T6075 prep with,interact
R4199 T6077 T6076 pobj proteins,with
R4200 T6078 T6077 acl possessing,proteins
R4201 T6079 T6081 det a,motif
R4202 T6126 T6089 punct .,p73
R4203 T6080 T6081 compound PPxY,motif
R4204 T6127 T6128 advmod Transiently,overexpressed
R4205 T6128 T6129 compound overexpressed,WWOX
R4206 T6081 T6078 dobj motif,possessing
R4207 T6129 T6130 nsubj WWOX,binds
R4208 T6130 T6130 ROOT binds,binds
R4209 T6082 T6081 punct (,motif
R4210 T6131 T6132 compound transcription,factors
R4211 T6132 T6130 dobj factors,binds
R4212 T6133 T6132 appos AP-2,factors
R4213 T6083 T6081 appos s,motif
R4214 T6134 T6133 punct ",",AP-2
R4215 T6084 T6081 punct ),motif
R4216 T6135 T6133 appos p73,AP-2
R4217 T6136 T6133 punct ",",AP-2
R4218 T6085 T6086 amod such,as
R4219 T6137 T6133 cc and,AP-2
R4220 T6138 T6133 conj c-Jun,AP-2
R4221 T6139 T6130 cc and,binds
R4222 T6140 T6130 conj block,binds
R4223 T6141 T6143 poss their,relocation
R4224 T6142 T6143 amod nuclear,relocation
R4225 T6086 T6078 prep as,possessing
R4226 T6143 T6140 dobj relocation,block
R4227 T6144 T6140 prep in,block
R4228 T6145 T6144 pobj vitro,in
R4229 T6087 T6086 pobj AP-2γ,as
R4230 T6146 T6145 punct ",",vitro
R4231 T6147 T6148 nsubj which,suppresses
R4232 T6148 T6145 relcl suppresses,vitro
R4233 T6088 T6087 punct ",",AP-2γ
R4234 T6149 T6150 compound cancer,cell
R4235 T6150 T6151 compound cell,survival
R4236 T6151 T6148 dobj survival,suppresses
R4237 T6089 T6087 conj p73,AP-2γ
R4238 T6152 T6155 punct (,al.
R4239 T6153 T6155 amod Salah,al.
R4240 T6090 T6089 punct ",",p73
R4241 T6154 T6155 nmod et,al.
R4242 T6155 T6148 npadvmod al.,suppresses
R4243 T6156 T6155 punct ",",al.
R4244 T6091 T6089 conj ErbB4,p73
R4245 T6157 T6155 npadvmod 2012,al.
R4246 T6158 T6155 punct ),al.
R4247 T6092 T6091 punct ",",ErbB4
R4248 T6159 T6130 punct .,binds
R4249 T6160 T6165 prep In,co-migrates
R4250 T6161 T6162 amod stark,contrast
R4251 T6093 T6091 conj Ezrin,ErbB4
R4252 T6162 T6160 pobj contrast,In
R4253 T6163 T6165 punct ",",co-migrates
R4254 T6164 T6165 nsubj Wwox,co-migrates
R4255 T6094 T6093 punct ",",Ezrin
R4256 T6165 T6165 ROOT co-migrates,co-migrates
R4257 T6166 T6165 prep with,co-migrates
R4258 T6167 T6171 amod proapoptotic,factors
R4259 T6095 T6093 conj SIMPLE,Ezrin
R4260 T6168 T6167 cc and,proapoptotic
R4261 T6169 T6167 conj pro-survival,proapoptotic
R4262 T6096 T6095 punct ",",SIMPLE
R4263 T6170 T6171 compound transcription,factors
R4264 T6171 T6166 pobj factors,with
R4265 T6172 T6165 prep to,co-migrates
R4266 T6173 T6174 det the,nuclei
R4267 T6097 T6095 conj c-Jun,SIMPLE
R4268 T6174 T6172 pobj nuclei,to
R4269 T6175 T6174 prep of,nuclei
R4270 T6098 T6097 punct ",",c-Jun
R4271 T6176 T6175 pobj neurons,of
R4272 T6177 T6174 prep upon,nuclei
R4273 T6178 T6180 amod sciatic,axotomy
R4274 T6099 T6097 conj RUNX4,c-Jun
R4275 T6100 T6099 punct ",",RUNX4
R4276 T6179 T6180 compound nerve,axotomy
R4277 T6101 T6089 cc and,p73
R4278 T6180 T6177 pobj axotomy,upon
R4279 T6181 T6180 prep in,axotomy
R4280 T6182 T6181 pobj rats,in
R4281 T6102 T6103 amod many,others
R4282 T6183 T6186 punct (,al.
R4283 T6184 T6186 compound Li,al.
R4284 T6185 T6186 nmod et,al.
R4285 T6103 T6089 conj others,p73
R4286 T6104 T6103 punct (,others
R4287 T6186 T6165 appos al.,co-migrates
R4288 T6105 T6107 compound Chang,al.
R4289 T6187 T6186 punct ",",al.
R4290 T6188 T6186 npadvmod 2009,al.
R4291 T6106 T6107 nmod et,al.
R4292 T6189 T6186 punct ),al.
R4293 T6190 T6165 punct .,co-migrates
R4294 T6107 T6103 appos al.,others
R4295 T6191 T6192 det No,blocking
R4296 T6192 T6204 nsubjpass blocking,observed
R4297 T6193 T6192 prep of,blocking
R4298 T6108 T6107 punct ",",al.
R4299 T6194 T6193 pobj translocation,of
R4300 T6195 T6194 prep of,translocation
R4301 T6196 T6197 compound transcription,factors
R4302 T6109 T6107 npadvmod 2007,al.
R4303 T6197 T6195 pobj factors,of
R4304 T6198 T6192 prep to,blocking
R4305 T6199 T6200 det the,nuclei
R4306 T6110 T6107 punct ;,al.
R4307 T6200 T6198 pobj nuclei,to
R4308 T6201 T6192 prep by,blocking
R4309 T6202 T6201 pobj Wwox,by
R4310 T6111 T6113 compound Salah,al.
R4311 T6203 T6204 auxpass was,observed
R4312 T6204 T6204 ROOT observed,observed
R4313 T6205 T6204 punct .,observed
R4314 T6112 T6113 nmod et,al.
R4315 T6206 T6212 prep Under,activated
R4316 T6207 T6208 compound stress,conditions
R4317 T6208 T6206 pobj conditions,Under
R4318 T6113 T6107 conj al.,al.
R4319 T6209 T6212 punct ",",activated
R4320 T6210 T6212 nsubjpass WWOX,activated
R4321 T6114 T6113 punct ",",al.
R4322 T6211 T6212 auxpass is,activated
R4323 T6212 T6212 ROOT activated,activated
R4324 T6213 T6212 prep via,activated
R4325 T6214 T6213 pobj phosphorylation,via
R4326 T6215 T6212 prep at,activated
R4327 T6216 T6215 pobj Tyr33,at
R4328 T6115 T6113 appos 2012,al.
R4329 T6217 T6212 punct ",",activated
R4330 T6218 T6212 cc and,activated
R4331 T6219 T6212 conj binds,activated
R4332 T6116 T6103 punct ;,others
R4333 T6220 T6219 dobj proteins,binds
R4334 T6221 T6219 advmod independently,binds
R4335 T6222 T6221 prep of,independently
R4336 T6117 T6119 compound Su,al.
R4337 T6118 T6119 compound et,al.
R4338 T6119 T6103 conj al.,others
R4339 T6120 T6119 punct ",",al.
R4340 T6223 T6225 det the,motif
R4341 T6224 T6225 compound PPxY,motif
R4342 T6121 T6119 npadvmod 2012,al.
R4343 T6225 T6222 pobj motif,of
R4344 T6226 T6229 punct (,al.
R4345 T6227 T6229 compound Chang,al.
R4346 T6122 T6103 punct ;,others
R4347 T6228 T6229 nmod et,al.
R4348 T6229 T6219 parataxis al.,binds
R4349 T6230 T6229 punct ",",al.
R4350 T6123 T6089 appos Figure,p73
R4351 T6231 T6229 npadvmod 2001,al.
R4352 T6232 T6231 punct ",",2001
R4353 T6233 T6231 conj 2003,2001
R4354 T6124 T6123 nummod 1,Figure
R4355 T6234 T6229 punct ",",al.
R4356 T6235 T6229 appos 2005a,al.
R4357 T6236 T6229 punct ",",al.
R4358 T6125 T6123 punct ),Figure
R4359 T6237 T6229 conj b,al.
R4360 T6238 T6237 punct ",",b
R4361 T6239 T6237 npadvmod 2007,b
R4362 T6320 T6322 nmod Bouteille,al.
R4363 T6240 T6239 punct ",",2007
R4364 T6241 T6239 conj 2010,2007
R4365 T6321 T6322 nmod et,al.
R4366 T6242 T6237 punct ),b
R4367 T6322 T6308 conj al.,Dvl-2
R4368 T6243 T6212 punct .,activated
R4369 T6244 T6245 compound Activated,WWOX
R4370 T6245 T6247 nsubj WWOX,interacts
R4371 T6323 T6322 punct ",",al.
R4372 T6246 T6247 advmod physically,interacts
R4373 T6247 T6247 ROOT interacts,interacts
R4374 T6248 T6247 prep with,interacts
R4375 T6249 T6251 nmod serine,p53
R4376 T6324 T6322 pobj 2009,al.
R4377 T6250 T6251 amod 46-phosphorylated,p53
R4378 T6251 T6248 pobj p53,with
R4379 T6252 T6253 punct (,Figure
R4380 T6325 T6308 punct ),Dvl-2
R4381 T6253 T6251 appos Figure,p53
R4382 T6254 T6253 nummod 1,Figure
R4383 T6255 T6253 punct ),Figure
R4384 T6326 T6305 punct .,overexpressed
R4385 T6256 T6251 punct ",",p53
R4386 T6257 T6258 nsubj which,stabilizes
R4387 T6258 T6251 relcl stabilizes,p53
R4388 T6327 T6328 compound Overexpressed,WWOX
R4389 T6259 T6258 dobj p53,stabilizes
R4390 T6328 T6329 nsubj WWOX,induces
R4391 T6260 T6259 cc and,p53
R4392 T6329 T6329 ROOT induces,induces
R4393 T6330 T6329 dobj apoptosis,induces
R4394 T6261 T6263 poss its,function
R4395 T6331 T6329 cc and,induces
R4396 T6262 T6263 amod apoptotic,function
R4397 T6332 T6329 conj inhibits,induces
R4398 T6263 T6259 conj function,p53
R4399 T6333 T6332 dobj proliferation,inhibits
R4400 T6334 T6333 prep of,proliferation
R4401 T6264 T6251 punct (,p53
R4402 T6265 T6267 compound Chang,al.
R4403 T6335 T6337 amod human,carcinoma
R4404 T6266 T6267 nmod et,al.
R4405 T6267 T6251 appos al.,p53
R4406 T6336 T6337 compound hepatic,carcinoma
R4407 T6268 T6267 punct ",",al.
R4408 T6269 T6267 appos 2005b,al.
R4409 T6270 T6251 punct ),p53
R4410 T6337 T6338 compound carcinoma,cells
R4411 T6271 T6247 punct .,interacts
R4412 T6272 T6275 advmod Also,binds
R4413 T6338 T6334 pobj cells,of
R4414 T6273 T6275 punct ",",binds
R4415 T6274 T6275 nsubj WWOX,binds
R4416 T6275 T6275 ROOT binds,binds
R4417 T6339 T6332 punct (,inhibits
R4418 T6276 T6277 amod Disheveled,proteins
R4419 T6277 T6275 dobj proteins,binds
R4420 T6278 T6279 punct (,Dvl
R4421 T6340 T6342 compound Hu,al.
R4422 T6279 T6275 npadvmod Dvl,binds
R4423 T6280 T6279 punct ),Dvl
R4424 T6281 T6275 punct ",",binds
R4425 T6282 T6283 nsubj which,are
R4426 T6283 T6275 relcl are,binds
R4427 T6284 T6285 amod key,components
R4428 T6341 T6342 nmod et,al.
R4429 T6285 T6283 attr components,are
R4430 T6286 T6285 prep in,components
R4431 T6287 T6289 compound Wnt,β-catenin
R4432 T6342 T6332 appos al.,inhibits
R4433 T6288 T6289 compound /,β-catenin
R4434 T6289 T6291 compound β-catenin,pathway
R4435 T6290 T6291 compound signaling,pathway
R4436 T6343 T6342 punct ",",al.
R4437 T6291 T6286 pobj pathway,in
R4438 T6292 T6291 punct (,pathway
R4439 T6293 T6291 appos Figure,pathway
R4440 T6344 T6342 npadvmod 2012,al.
R4441 T6294 T6293 nummod 1,Figure
R4442 T6295 T6291 punct ),pathway
R4443 T6296 T6275 punct .,binds
R4444 T6297 T6299 det No,motif
R4445 T6345 T6332 punct ),inhibits
R4446 T6298 T6299 compound PPxY,motif
R4447 T6299 T6300 nsubj motif,is
R4448 T6300 T6300 ROOT is,is
R4449 T6301 T6300 prep in,is
R4450 T6346 T6332 cc and,inhibits
R4451 T6302 T6301 pobj Dvl,in
R4452 T6303 T6300 punct .,is
R4453 T6347 T6350 amod many,types
R4454 T6348 T6349 compound cancer,cell
R4455 T6304 T6305 advmod Transiently,overexpressed
R4456 T6349 T6350 compound cell,types
R4457 T6305 T6305 ROOT overexpressed,overexpressed
R4458 T6350 T6332 conj types,inhibits
R4459 T6306 T6307 compound WWOX,sequesters
R4460 T6307 T6308 compound sequesters,Dvl-2
R4461 T6351 T6332 punct (,inhibits
R4462 T6308 T6305 nsubjpass Dvl-2,overexpressed
R4463 T6309 T6308 prep in,Dvl-2
R4464 T6310 T6311 det the,cytoplasm
R4465 T6352 T6354 compound Chang,al.
R4466 T6311 T6309 pobj cytoplasm,in
R4467 T6312 T6309 cc and,in
R4468 T6353 T6354 nmod et,al.
R4469 T6313 T6314 advmod thereby,blocks
R4470 T6314 T6322 nmod blocks,al.
R4471 T6315 T6318 nmod Dvl-2-mediated,activity
R4472 T6316 T6318 nmod TCF,activity
R4473 T6354 T6332 appos al.,inhibits
R4474 T6317 T6318 amod transcriptional,activity
R4475 T6318 T6322 nmod activity,al.
R4476 T6319 T6322 punct (,al.
R4477 T6355 T6354 punct ",",al.
R4478 T6356 T6354 appos 2007,al.
R4479 T6417 T6414 conj stress,chemicals
R4480 T6357 T6356 punct ",",2007
R4481 T6418 T6417 punct ",",stress
R4482 T6419 T6420 amod such,as
R4483 T6358 T6356 conj 2010,2007
R4484 T6359 T6354 punct ;,al.
R4485 T6420 T6414 prep as,chemicals
R4486 T6360 T6362 compound Salah,al.
R4487 T6421 T6422 compound UV,irradiation
R4488 T6361 T6362 nmod et,al.
R4489 T6422 T6420 pobj irradiation,as
R4490 T6423 T6422 cc and,irradiation
R4491 T6424 T6425 amod chemotherapeutic,drugs
R4492 T6362 T6354 conj al.,al.
R4493 T6425 T6422 conj drugs,irradiation
R4494 T6426 T6428 punct ",",undergoes
R4495 T6363 T6362 punct ",",al.
R4496 T6427 T6428 nsubj WWOX,undergoes
R4497 T6428 T6428 ROOT undergoes,undergoes
R4498 T6429 T6428 dobj phosphorylation,undergoes
R4499 T6364 T6362 npadvmod 2012,al.
R4500 T6430 T6428 prep in,undergoes
R4501 T6365 T6332 punct ;,inhibits
R4502 T6431 T6430 pobj Tyr33,in
R4503 T6432 T6431 cc and,Tyr33
R4504 T6433 T6434 advmod probably,others
R4505 T6366 T6368 compound Su,al.
R4506 T6434 T6431 conj others,Tyr33
R4507 T6435 T6430 pobj sites,in
R4508 T6436 T6435 punct ",",sites
R4509 T6367 T6368 compound et,al.
R4510 T6437 T6435 acl followed,sites
R4511 T6438 T6437 agent by,followed
R4512 T6439 T6438 pcomp relocating,by
R4513 T6440 T6439 prep to,relocating
R4514 T6368 T6332 conj al.,inhibits
R4515 T6441 T6440 pobj mitochondria,to
R4516 T6442 T6441 cc or,mitochondria
R4517 T6369 T6368 punct ",",al.
R4518 T6443 T6441 conj nuclei,mitochondria
R4519 T6444 T6439 prep for,relocating
R4520 T6445 T6444 pcomp inducing,for
R4521 T6370 T6368 npadvmod 2012,al.
R4522 T6446 T6445 dobj apoptosis,inducing
R4523 T6447 T6450 punct (,al.
R4524 T6448 T6450 compound Chang,al.
R4525 T6449 T6450 nmod et,al.
R4526 T6450 T6450 ROOT al.,al.
R4527 T6451 T6450 punct ",",al.
R4528 T6371 T6368 punct ),al.
R4529 T6452 T6450 npadvmod 2007,al.
R4530 T6453 T6452 punct ",",2007
R4531 T6454 T6452 conj 2010,2007
R4532 T6455 T6450 punct ),al.
R4533 T6372 T6329 punct .,induces
R4534 T6456 T6450 punct .,al.
R4535 T6457 T6458 nsubj WWOX,binds
R4536 T6458 T6458 ROOT binds,binds
R4537 T6373 T6374 nsubj WWOX,enhances
R4538 T6459 T6458 dobj MEK,binds
R4539 T6460 T6458 prep in,binds
R4540 T6461 T6462 compound Jurkat,T
R4541 T6374 T6374 ROOT enhances,enhances
R4542 T6462 T6463 compound T,cells
R4543 T6463 T6460 pobj cells,in
R4544 T6375 T6377 det the,function
R4545 T6464 T6467 punct (,al.
R4546 T6465 T6467 compound Lin,al.
R4547 T6466 T6467 nmod et,al.
R4548 T6467 T6458 npadvmod al.,binds
R4549 T6376 T6377 amod cytotoxic,function
R4550 T6468 T6467 punct ",",al.
R4551 T6469 T6467 npadvmod 2011,al.
R4552 T6377 T6374 dobj function,enhances
R4553 T6378 T6377 prep of,function
R4554 T6379 T6380 compound tumor,necrosis
R4555 T6470 T6467 punct ),al.
R4556 T6471 T6458 punct .,binds
R4557 T6380 T6381 compound necrosis,factor
R4558 T6472 T6474 nmod Phorbol,acetate
R4559 T6473 T6474 compound myristate,acetate
R4560 T6381 T6378 pobj factor,of
R4561 T6474 T6478 nsubj acetate,dissociates
R4562 T6475 T6476 punct (,PMA
R4563 T6476 T6474 appos PMA,acetate
R4564 T6382 T6377 prep by,function
R4565 T6477 T6474 punct ),acetate
R4566 T6478 T6478 ROOT dissociates,dissociates
R4567 T6383 T6386 amod down-regulating,Bcl-2
R4568 T6479 T6481 det the,complex
R4569 T6480 T6481 compound MEK/WWOX,complex
R4570 T6481 T6478 dobj complex,dissociates
R4571 T6482 T6478 cc and,dissociates
R4572 T6384 T6385 compound apoptosis,inhibitor
R4573 T6483 T6478 conj induces,dissociates
R4574 T6484 T6483 dobj WWOX,induces
R4575 T6485 T6486 aux to,translocate
R4576 T6486 T6483 xcomp translocate,induces
R4577 T6487 T6486 prep to,translocate
R4578 T6488 T6489 det the,mitochondria
R4579 T6385 T6386 compound inhibitor,Bcl-2
R4580 T6489 T6487 pobj mitochondria,to
R4581 T6490 T6491 aux to,induce
R4582 T6491 T6486 advcl induce,translocate
R4583 T6386 T6382 pobj Bcl-2,by
R4584 T6492 T6491 dobj apoptosis,induce
R4585 T6493 T6483 punct ",",induces
R4586 T6494 T6496 mark whereas,relocates
R4587 T6495 T6496 nsubj MEK,relocates
R4588 T6387 T6386 cc and,Bcl-2
R4589 T6496 T6483 advcl relocates,induces
R4590 T6497 T6496 prep to,relocates
R4591 T6498 T6500 det the,raft
R4592 T6388 T6392 nmod Bcl-xL,p53
R4593 T6499 T6500 amod lipid,raft
R4594 T6389 T6388 cc and,Bcl-xL
R4595 T6390 T6388 conj up-regulating,Bcl-xL
R4596 T6500 T6497 pobj raft,to
R4597 T6391 T6392 amod apoptotic,p53
R4598 T6392 T6386 conj p53,Bcl-2
R4599 T6501 T6478 punct .,dissociates
R4600 T6502 T6506 nsubj Inhibition,increases
R4601 T6393 T6396 punct (,al.
R4602 T6503 T6502 prep of,Inhibition
R4603 T6504 T6505 compound MEK,activity
R4604 T6505 T6503 pobj activity,of
R4605 T6394 T6396 compound Chang,al.
R4606 T6506 T6506 ROOT increases,increases
R4607 T6507 T6508 amod TMZ-induced,suppression
R4608 T6508 T6506 dobj suppression,increases
R4609 T6395 T6396 nmod et,al.
R4610 T6509 T6508 prep of,suppression
R4611 T6510 T6511 compound cancer,cell
R4612 T6396 T6396 ROOT al.,al.
R4613 T6511 T6512 compound cell,growth
R4614 T6512 T6509 pobj growth,of
R4615 T6513 T6516 punct (,al.
R4616 T6397 T6396 punct ",",al.
R4617 T6398 T6396 npadvmod 2001,al.
R4618 T6399 T6396 punct ),al.
R4619 T6514 T6516 compound Holt,al.
R4620 T6400 T6396 punct .,al.
R4621 T6515 T6516 nmod et,al.
R4622 T6516 T6506 npadvmod al.,increases
R4623 T6401 T6404 advmod Also,mediates
R4624 T6517 T6516 punct ",",al.
R4625 T6518 T6516 npadvmod 2012,al.
R4626 T6519 T6516 punct ),al.
R4627 T6520 T6506 punct .,increases
R4628 T6521 T6522 amod Ectopic,expression
R4629 T6522 T6528 nsubj expression,induces
R4630 T6402 T6404 punct ",",mediates
R4631 T6523 T6522 prep of,expression
R4632 T6524 T6523 pobj WWOX,of
R4633 T6525 T6522 prep in,expression
R4634 T6403 T6404 nsubj WWOX,mediates
R4635 T6526 T6527 compound A549,cells
R4636 T6527 T6525 pobj cells,in
R4637 T6528 T6528 ROOT induces,induces
R4638 T6404 T6404 ROOT mediates,mediates
R4639 T6529 T6532 amod procaspase-3,activation
R4640 T6530 T6529 cc and,procaspase-3
R4641 T6405 T6406 compound cell,death
R4642 T6531 T6529 conj procaspase-9,procaspase-3
R4643 T6532 T6528 dobj activation,induces
R4644 T6533 T6528 cc and,induces
R4645 T6406 T6404 dobj death,mediates
R4646 T6534 T6528 conj induces,induces
R4647 T6535 T6536 compound cytochrome,C
R4648 T6536 T6534 dobj C,induces
R4649 T6537 T6534 advcl releasing,induces
R4650 T6407 T6404 advmod synergistically,mediates
R4651 T6538 T6537 prep from,releasing
R4652 T6539 T6540 det the,mitochondria
R4653 T6408 T6404 prep with,mediates
R4654 T6540 T6538 pobj mitochondria,from
R4655 T6541 T6540 punct (,mitochondria
R4656 T6542 T6544 compound Zhang,al.
R4657 T6409 T6408 pobj p53,with
R4658 T6543 T6544 nmod et,al.
R4659 T6544 T6540 appos al.,mitochondria
R4660 T6545 T6540 punct ",",mitochondria
R4661 T6410 T6404 punct .,mediates
R4662 T6546 T6540 amod 2012a,mitochondria
R4663 T6547 T6534 punct ),induces
R4664 T6411 T6428 prep Upon,undergoes
R4665 T6548 T6528 punct .,induces
R4666 T6549 T6550 compound Complement,C1q
R4667 T6550 T6551 nsubj C1q,induces
R4668 T6412 T6411 pobj exposure,Upon
R4669 T6551 T6551 ROOT induces,induces
R4670 T6552 T6554 amod ectopic,phosphorylation
R4671 T6413 T6412 prep to,exposure
R4672 T6553 T6554 compound WWOX,phosphorylation
R4673 T6554 T6551 dobj phosphorylation,induces
R4674 T6414 T6413 pobj chemicals,to
R4675 T6555 T6554 prep in,phosphorylation
R4676 T6556 T6555 pobj Try33,in
R4677 T6557 T6551 cc and,induces
R4678 T6558 T6551 conj leads,induces
R4679 T6559 T6558 prep to,leads
R4680 T6415 T6414 cc or,chemicals
R4681 T6560 T6561 compound cell,apoptosis
R4682 T6561 T6559 pobj apoptosis,to
R4683 T6416 T6417 amod environmental,stress
R4684 T6562 T6561 advmod independently,apoptosis
R4685 T6563 T6561 prep of,apoptosis
R4686 T6564 T6568 det the,pathway
R4687 T6611 T6609 dobj factor,Transforming
R4688 T6565 T6568 amod classical,pathway
R4689 T6566 T6568 compound complement,pathway
R4690 T6567 T6568 compound activation,pathway
R4691 T6568 T6563 pobj pathway,of
R4692 T6612 T6613 nummod β1,binds
R4693 T6569 T6572 punct (,al.
R4694 T6570 T6572 nmod Hong,al.
R4695 T6571 T6572 nmod et,al.
R4696 T6613 T6609 nsubj binds,Transforming
R4697 T6572 T6561 appos al.,apoptosis
R4698 T6573 T6572 punct ",",al.
R4699 T6574 T6572 npadvmod 2009,al.
R4700 T6614 T6613 dobj Hyal-2,binds
R4701 T6575 T6558 punct ),leads
R4702 T6576 T6551 punct .,induces
R4703 T6577 T6578 det A,portion
R4704 T6578 T6582 nsubjpass portion,anchored
R4705 T6615 T6614 prep as,Hyal-2
R4706 T6579 T6578 prep of,portion
R4707 T6616 T6618 det a,receptor
R4708 T6580 T6579 pobj WWOX,of
R4709 T6617 T6618 compound cognate,receptor
R4710 T6618 T6615 pobj receptor,as
R4711 T6581 T6582 auxpass is,anchored
R4712 T6582 T6582 ROOT anchored,anchored
R4713 T6619 T6620 aux to,signal
R4714 T6583 T6582 prep in,anchored
R4715 T6584 T6586 det the,area
R4716 T6620 T6613 advcl signal,binds
R4717 T6585 T6586 amod membrane/cytoskeleton,area
R4718 T6586 T6583 pobj area,in
R4719 T6587 T6582 prep via,anchored
R4720 T6621 T6622 det the,formation
R4721 T6588 T6587 amod binding,via
R4722 T6589 T6588 prep with,binding
R4723 T6622 T6620 dobj formation,signal
R4724 T6590 T6591 compound hyaluronidase,Hyal-2
R4725 T6591 T6589 pobj Hyal-2,with
R4726 T6592 T6595 punct (,al.
R4727 T6593 T6595 compound Hsu,al.
R4728 T6594 T6595 nmod et,al.
R4729 T6595 T6591 appos al.,Hyal-2
R4730 T6623 T6622 prep of,formation
R4731 T6596 T6595 punct ",",al.
R4732 T6597 T6595 npadvmod 2009,al.
R4733 T6624 T6629 det the,complex
R4734 T6598 T6595 punct ),al.
R4735 T6599 T6591 cc and,Hyal-2
R4736 T6600 T6591 conj Phospho-Ezrin,Hyal-2
R4737 T6625 T6628 compound WWOX/Hyal,Smad4
R4738 T6601 T6604 punct (,al.
R4739 T6602 T6604 compound Jin,al.
R4740 T6603 T6604 nmod et,al.
R4741 T6626 T6627 compound -2,/
R4742 T6604 T6600 parataxis al.,Phospho-Ezrin
R4743 T6605 T6604 punct ",",al.
R4744 T6606 T6604 npadvmod 2006,al.
R4745 T6627 T6628 compound /,Smad4
R4746 T6607 T6604 punct ),al.
R4747 T6608 T6582 punct .,anchored
R4748 T6609 T6609 ROOT Transforming,Transforming
R4749 T6628 T6629 compound Smad4,complex
R4750 T6610 T6611 compound growth,factor
R4751 T6629 T6623 pobj complex,of
R4752 T6630 T6631 aux to,relocate
R4753 T6631 T6620 xcomp relocate,signal
R4754 T6632 T6631 prep to,relocate
R4755 T6633 T6634 det the,nucleus
R4756 T6634 T6632 pobj nucleus,to
R4757 T6635 T6634 prep for,nucleus
R4758 T6636 T6635 pcomp enhancing,for
R4759 T6637 T6640 det the,activity
R4760 T6638 T6640 amod SMAD-driven,activity
R4761 T6639 T6640 compound promoter,activity
R4762 T6640 T6636 dobj activity,enhancing
R4763 T6641 T6644 punct (,al.
R4764 T6642 T6644 compound Hsu,al.
R4765 T6643 T6644 nmod et,al.
R4766 T6644 T6613 dep al.,binds
R4767 T6645 T6644 punct ",",al.
R4768 T6646 T6644 npadvmod 2009,al.
R4769 T6647 T6644 punct ),al.
R4770 T6648 T6609 punct .,Transforming
R5005 T7155 T7158 amod Activated,apoptosis
R5006 T7156 T7158 nmod p53,apoptosis
R5007 T7157 T7158 compound mediates,apoptosis
R5008 T7158 T7158 ROOT apoptosis,apoptosis
R5009 T7159 T7162 punct ",",arrest
R5010 T7160 T7161 compound cell,cycle
R5011 T7161 T7162 compound cycle,arrest
R5012 T7162 T7158 appos arrest,apoptosis
R5013 T7163 T7162 punct ",",arrest
R5014 T7164 T7162 appos senescence,arrest
R5015 T7165 T7162 punct ",",arrest
R5016 T7166 T7167 compound DNA,repair
R5017 T7167 T7162 appos repair,arrest
R5018 T7168 T7167 punct ",",repair
R5019 T7169 T7167 cc or,repair
R5020 T7170 T7167 conj metabolism,repair
R5021 T7171 T7167 punct (,repair
R5022 T7172 T7167 appos Lane,repair
R5023 T7173 T7172 cc and,Lane
R5024 T7174 T7172 conj Levine,Lane
R5025 T7175 T7174 punct ",",Levine
R5026 T7176 T7174 npadvmod 2010,Levine
R5027 T7177 T7174 punct ),Levine
R5028 T7178 T7162 punct .,arrest
R5029 T7179 T7181 det The,structures
R5030 T7180 T7181 amod primary,structures
R5031 T7181 T7188 nsubjpass structures,depicted
R5032 T7182 T7181 prep of,structures
R5033 T7183 T7182 pobj p53,of
R5034 T7184 T7183 cc and,p53
R5035 T7185 T7186 poss its,isoforms
R5036 T7186 T7188 nsubjpass isoforms,depicted
R5037 T7187 T7188 auxpass are,depicted
R5038 T7188 T7188 ROOT depicted,depicted
R5039 T7189 T7190 punct (,Figure
R5040 T7190 T7188 oprd Figure,depicted
R5041 T7191 T7190 nummod 2,Figure
R5042 T7192 T7190 punct ),Figure
R5043 T7193 T7188 punct .,depicted
R5044 T7194 T7195 nsubj p53,induces
R5045 T7195 T7195 ROOT induces,induces
R5046 T7196 T7197 compound cell,cycle
R5047 T7197 T7198 compound cycle,arrest
R5048 T7198 T7195 dobj arrest,induces
R5049 T7199 T7195 prep by,induces
R5050 T7200 T7199 pcomp transactivating,by
R5051 T7201 T7200 dobj genes,transactivating
R5052 T7202 T7203 amod such,as
R5053 T7203 T7201 prep as,genes
R5054 T7204 T7206 amod cyclin-dependent,inhibitor
R5055 T7205 T7206 compound kinase,inhibitor
R5056 T7206 T7203 pobj inhibitor,as
R5057 T7207 T7206 nummod p21,inhibitor
R5058 T7208 T7207 punct ",",p21
R5059 T7209 T7206 cc or,inhibitor
R5060 T7210 T7211 compound microRNA,miR34
R5061 T7211 T7206 conj miR34,inhibitor
R5062 T7212 T7195 punct .,induces
R5063 T7213 T7214 nsubj p53,induces
R5064 T7214 T7214 ROOT induces,induces
R5065 T7215 T7214 dobj apoptosis,induces
R5066 T7216 T7214 prep by,induces
R5067 T7217 T7216 pcomp transactivating,by
R5068 T7218 T7219 amod proapoptotic,genes
R5069 T7219 T7217 dobj genes,transactivating
R5070 T7220 T7221 amod such,as
R5071 T7221 T7219 prep as,genes
R5072 T7222 T7221 pobj BAX,as
R5073 T7223 T7222 punct ",",BAX
R5074 T7224 T7222 conj PUMA,BAX
R5075 T7225 T7224 punct ",",PUMA
R5076 T7226 T7224 conj SCOTIN,PUMA
R5077 T7227 T7226 punct ",",SCOTIN
R5078 T7228 T7226 cc and,SCOTIN
R5079 T7229 T7226 conj FAS,SCOTIN
R5080 T7230 T7229 punct ",",FAS
R5081 T7231 T7217 cc and,transactivating
R5082 T7232 T7217 conj inhibiting,transactivating
R5083 T7233 T7236 det the,BCL-2
R5084 T7234 T7235 amod antiapoptotic,gene
R5085 T7235 T7236 compound gene,BCL-2
R5086 T7236 T7232 dobj BCL-2,inhibiting
R5087 T7237 T7236 punct (,BCL-2
R5088 T7238 T7236 appos Lane,BCL-2
R5089 T7239 T7238 cc and,Lane
R5090 T7240 T7238 conj Levine,Lane
R5091 T7241 T7240 punct ",",Levine
R5092 T7242 T7240 npadvmod 2010,Levine
R5093 T7243 T7240 punct ),Levine
R5094 T7244 T7214 punct .,induces
R5095 T7245 T7246 nsubj p53,triggers
R5096 T7246 T7246 ROOT triggers,triggers
R5097 T7247 T7251 amod pro-survival,response
R5098 T7248 T7247 cc or,pro-survival
R5099 T7249 T7247 conj cell,pro-survival
R5100 T7250 T7251 compound death,response
R5101 T7251 T7246 dobj response,triggers
R5102 T7252 T7246 punct ",",triggers
R5103 T7253 T7246 advcl depending,triggers
R5104 T7254 T7253 prep upon,depending
R5105 T7255 T7256 compound cell,types
R5106 T7256 T7254 pobj types,upon
R5107 T7257 T7253 punct ",",depending
R5108 T7258 T7259 det the,intensity
R5109 T7259 T7246 dobj intensity,triggers
R5110 T7260 T7259 prep of,intensity
R5111 T7261 T7263 det the,signal
R5112 T7262 T7263 compound stress,signal
R5113 T7263 T7260 pobj signal,of
R5114 T7264 T7259 punct ",",intensity
R5115 T7265 T7259 cc and,intensity
R5116 T7266 T7267 det the,extent
R5117 T7267 T7259 conj extent,intensity
R5118 T7268 T7267 prep of,extent
R5119 T7269 T7270 amod cellular,damage
R5120 T7270 T7268 pobj damage,of
R5121 T7271 T7274 punct (,al.
R5122 T7272 T7274 compound Menendez,al.
R5123 T7273 T7274 nmod et,al.
R5124 T7274 T7267 conj al.,extent
R5125 T7275 T7274 punct ",",al.
R5126 T7276 T7274 npadvmod 2009,al.
R5127 T7277 T7274 punct ),al.
R5128 T7278 T7246 punct .,triggers
R5129 T7279 T7282 advmod Also,plays
R5130 T7280 T7282 punct ",",plays
R5131 T7281 T7282 nsubj p53,plays
R5132 T7282 T7282 ROOT plays,plays
R5133 T7283 T7284 det a,role
R5134 T7284 T7282 dobj role,plays
R5135 T7285 T7284 prep in,role
R5136 T7286 T7285 pcomp controlling,in
R5137 T7287 T7288 compound cell,motility
R5138 T7288 T7286 dobj motility,controlling
R5139 T7289 T7286 prep via,controlling
R5140 T7290 T7289 pcomp regulating,via
R5141 T7291 T7292 det the,expression
R5142 T7292 T7290 dobj expression,regulating
R5143 T7293 T7292 prep of,expression
R5144 T7294 T7296 amod smooth,α-actin
R5145 T7295 T7296 compound muscle,α-actin
R5146 T7296 T7293 pobj α-actin,of
R5147 T7297 T7300 punct (,al.
R5148 T7298 T7300 compound Comer,al.
R5149 T7299 T7300 nmod et,al.
R5150 T7300 T7292 appos al.,expression
R5151 T7301 T7300 punct ",",al.
R5152 T7302 T7300 npadvmod 1998,al.
R5153 T7303 T7292 punct ),expression
R5154 T7304 T7282 punct ",",plays
R5155 T7305 T7282 conj collagens,plays
R5156 T7306 T7305 dobj IIα1,collagens
R5157 T7307 T7306 cc and,IIα1
R5158 T7308 T7306 conj VIα1,IIα1
R5159 T7309 T7312 punct (,al.
R5160 T7310 T7312 compound Sun,al.
R5161 T7311 T7312 nmod et,al.
R5162 T7312 T7308 parataxis al.,VIα1
R5163 T7313 T7312 punct ",",al.
R5164 T7314 T7312 npadvmod 1999,al.
R5165 T7315 T7312 punct ),al.
R5166 T7316 T7312 punct ",",al.
R5167 T7317 T7312 cc and,al.
R5168 T7318 T7319 amod many,others
R5169 T7319 T7312 conj others,al.
R5170 T7320 T7282 punct .,plays
R5527 T7989 T7990 advmod At,least
R5528 T7990 T7991 advmod least,nine
R5529 T7991 T7992 nummod nine,isoforms
R5530 T7992 T7997 nsubjpass isoforms,identified
R5531 T7993 T7992 prep of,isoforms
R5532 T7994 T7993 pobj p53,of
R5533 T7995 T7997 aux have,identified
R5534 T7996 T7997 auxpass been,identified
R5535 T7997 T7997 ROOT identified,identified
R5536 T7998 T8002 amod due,splicing
R5537 T7999 T8000 aux to,alternative
R5538 T8000 T7998 xcomp alternative,due
R5539 T8001 T8002 compound mRNA,splicing
R5540 T8002 T7997 dobj splicing,identified
R5541 T8003 T8002 punct ",",splicing
R5542 T8004 T8006 amod multiple,promoters
R5543 T8005 T8006 compound gene,promoters
R5544 T8006 T8002 conj promoters,splicing
R5545 T8007 T8006 punct ",",promoters
R5546 T8008 T8006 cc and,promoters
R5547 T8009 T8011 amod alternative,sites
R5548 T8010 T8011 compound initiation,sites
R5549 T8011 T8006 conj sites,promoters
R5550 T8012 T8011 prep of,sites
R5551 T8013 T8012 pobj translation,of
R5552 T8014 T8002 punct (,splicing
R5553 T8015 T8017 compound Ghosh,al.
R5554 T8016 T8017 nmod et,al.
R5555 T8017 T8002 appos al.,splicing
R5556 T8018 T8017 punct ",",al.
R5557 T8019 T8017 appos 2004,al.
R5558 T8020 T8002 punct ;,splicing
R5559 T8021 T8023 compound Ray,al.
R5560 T8022 T8023 nmod et,al.
R5561 T8023 T8002 conj al.,splicing
R5562 T8024 T8023 punct ",",al.
R5563 T8025 T8023 appos 2006,al.
R5564 T8026 T8023 punct ;,al.
R5565 T8027 T8023 appos Figure,al.
R5566 T8028 T8027 nummod 2,Figure
R5567 T8029 T8023 punct ),al.
R5568 T8030 T7997 punct .,identified
R5569 T8031 T8039 prep In,occurs
R5570 T8032 T8031 pobj cancers,In
R5571 T8033 T8035 punct ",",expression
R5572 T8034 T8035 amod aberrant,expression
R5573 T8035 T8039 nsubj expression,occurs
R5574 T8036 T8035 prep of,expression
R5575 T8037 T8038 compound p53,isoforms
R5576 T8038 T8036 pobj isoforms,of
R5577 T8039 T8039 ROOT occurs,occurs
R5578 T8040 T8039 advmod frequently,occurs
R5579 T8041 T8044 punct (,al.
R5580 T8042 T8044 nmod Bourdon,al.
R5581 T8043 T8044 nmod et,al.
R5582 T8044 T8039 parataxis al.,occurs
R5583 T8045 T8044 punct ",",al.
R5584 T8046 T8044 npadvmod 2005,al.
R5585 T8047 T8048 punct ;,Bourdon
R5586 T8048 T8039 nsubj Bourdon,occurs
R5587 T8049 T8048 punct ",",Bourdon
R5588 T8050 T8048 npadvmod 2007,Bourdon
R5589 T8051 T8048 punct ),Bourdon
R5590 T8052 T8039 punct .,occurs
R5591 T8053 T8054 amod Full-length,p53
R5592 T8054 T8061 nsubjpass p53,localized
R5593 T8055 T8054 punct ",",p53
R5594 T8056 T8054 conj Δ133p53,p53
R5595 T8057 T8056 punct ",",Δ133p53
R5596 T8058 T8056 cc and,Δ133p53
R5597 T8059 T8056 conj p53β,Δ133p53
R5598 T8060 T8061 auxpass are,localized
R5599 T8061 T8061 ROOT localized,localized
R5600 T8062 T8063 advmod mainly,in
R5601 T8063 T8061 prep in,localized
R5602 T8064 T8065 det the,nucleus
R5603 T8065 T8063 pobj nucleus,in
R5604 T8066 T8061 punct ",",localized
R5605 T8067 T8061 cc and,localized
R5606 T8068 T8069 advmod only,few
R5607 T8069 T8072 nsubj few,are
R5608 T8070 T8069 prep of,few
R5609 T8071 T8070 pobj them,of
R5610 T8072 T8061 conj are,localized
R5611 T8073 T8072 prep in,are
R5612 T8074 T8073 pobj cytoplasm,in
R5613 T8075 T8072 punct .,are
R5614 T8076 T8080 nsubjpass p53γ,localized
R5615 T8077 T8076 cc and,p53γ
R5616 T8078 T8076 conj Δ133p53β,p53γ
R5617 T8079 T8080 auxpass are,localized
R5618 T8080 T8080 ROOT localized,localized
R5619 T8081 T8080 prep in,localized
R5620 T8082 T8083 det the,nucleus
R5621 T8083 T8081 pobj nucleus,in
R5622 T8084 T8083 cc and,nucleus
R5623 T8085 T8083 conj cytoplasm,nucleus
R5624 T8086 T8080 punct .,localized
R5625 T8087 T8089 nsubjpass Δ133p53γ,localized
R5626 T8088 T8089 auxpass is,localized
R5627 T8089 T8089 ROOT localized,localized
R5628 T8090 T8089 prep in,localized
R5629 T8091 T8092 det the,cytoplasm
R5630 T8092 T8090 pobj cytoplasm,in
R5631 T8093 T8096 punct (,al.
R5632 T8094 T8096 compound Bourdon,al.
R5633 T8095 T8096 nmod et,al.
R5634 T8096 T8089 npadvmod al.,localized
R5635 T8097 T8096 punct ",",al.
R5636 T8098 T8096 npadvmod 2005,al.
R5637 T8099 T8096 punct ),al.
R5638 T8100 T8089 punct .,localized
R5639 T8101 T8106 nmod Co-transfection,increases
R5640 T8102 T8101 prep of,Co-transfection
R5641 T8103 T8102 pobj p53,of
R5642 T8104 T8103 cc and,p53
R5643 T8105 T8106 amod p53β,increases
R5644 T8106 T8106 ROOT increases,increases
R5645 T8107 T8108 compound p53-mediated,apoptosis
R5646 T8108 T8106 dobj apoptosis,increases
R5647 T8109 T8106 punct ",",increases
R5648 T8110 T8122 nmod whereas,al.
R5649 T8111 T8122 dep co-expression,al.
R5650 T8112 T8111 prep of,co-expression
R5651 T8113 T8112 pobj p53,of
R5652 T8114 T8111 prep with,co-expression
R5653 T8115 T8116 amod Δ133p53,suppresses
R5654 T8116 T8114 pobj suppresses,with
R5655 T8117 T8118 nmod p53-mediated,apoptosis
R5656 T8118 T8111 conj apoptosis,co-expression
R5657 T8119 T8122 punct (,al.
R5658 T8120 T8122 compound Bourdon,al.
R5659 T8121 T8122 nmod et,al.
R5660 T8122 T8106 advcl al.,increases
R5661 T8123 T8122 punct ",",al.
R5662 T8124 T8122 npadvmod 2005,al.
R5663 T8125 T8122 punct ),al.
R5664 T8126 T8106 punct .,increases
R5665 T8127 T8129 nsubj Δ133p53,regulates
R5666 T8128 T8129 advmod differentially,regulates
R5667 T8129 T8129 ROOT regulates,regulates
R5668 T8130 T8131 compound gene,expression
R5669 T8131 T8129 dobj expression,regulates
R5670 T8132 T8131 prep in,expression
R5671 T8133 T8132 pobj p53-dependent,in
R5672 T8134 T8129 cc and,regulates
R5673 T8135 T8129 punct -,regulates
R5674 T8136 T8137 amod independent,manners
R5675 T8137 T8129 conj manners,regulates
R5676 T8138 T8137 punct (,manners
R5677 T8139 T8141 compound Aoubala,al.
R5678 T8140 T8141 nmod et,al.
R5679 T8141 T8137 appos al.,manners
R5680 T8142 T8141 punct ",",al.
R5681 T8143 T8141 npadvmod 2011,al.
R5682 T8144 T8137 punct ),manners
R5683 T8145 T8129 punct .,regulates
R5684 T8146 T8155 nsubj Co-expression,affect
R5685 T8147 T8146 prep of,Co-expression
R5686 T8148 T8147 pobj Δ133p53β,of
R5687 T8149 T8148 cc or,Δ133p53β
R5688 T8150 T8148 conj Δ133p53γ,Δ133p53β
R5689 T8151 T8146 prep with,Co-expression
R5690 T8152 T8151 pobj p53,with
R5691 T8153 T8155 aux does,affect
R5692 T8154 T8155 neg not,affect
R5693 T8155 T8155 ROOT affect,affect
R5694 T8156 T8158 nmod p53,activity
R5695 T8157 T8158 compound transcriptional,activity
R5696 T8158 T8155 dobj activity,affect
R5697 T8159 T8158 prep on,activity
R5698 T8160 T8159 pobj p21,on
R5699 T8161 T8155 cc and,affect
R5700 T8162 T8163 compound Bax,promoters
R5701 T8163 T8163 ROOT promoters,promoters
R5702 T8164 T8163 punct ",",promoters
R5703 T8165 T8167 advmod as,as
R5704 T8166 T8167 advmod well,as
R5705 T8167 T8163 cc as,promoters
R5706 T8168 T8163 conj apoptosis,promoters
R5707 T8169 T8155 punct .,affect
R6238 T9180 T9181 compound p53,mutants
R6239 T9181 T9183 nsubjpass mutants,considered
R6240 T9182 T9183 auxpass are,considered
R6241 T9183 T9219 ccomp considered,al.
R6242 T9184 T9183 prep as,considered
R6243 T9185 T9186 amod unfavorable,factors
R6244 T9186 T9184 pobj factors,as
R6245 T9187 T9186 prep for,factors
R6246 T9188 T9189 det the,effectiveness
R6247 T9189 T9187 pobj effectiveness,for
R6248 T9190 T9189 prep in,effectiveness
R6249 T9191 T9194 amod radiotherapy,treatment
R6250 T9192 T9191 cc and,radiotherapy
R6251 T9193 T9194 compound TMZ,treatment
R6252 T9194 T9190 pobj treatment,in
R6253 T9195 T9189 prep in,effectiveness
R6254 T9196 T9197 compound glioma,cells
R6255 T9197 T9195 pobj cells,in
R6256 T9198 T9201 punct (,al.
R6257 T9199 T9201 nmod Gjerset,al.
R6258 T9200 T9201 nmod et,al.
R6259 T9201 T9186 appos al.,factors
R6260 T9202 T9201 punct ",",al.
R6261 T9203 T9201 npadvmod 1995,al.
R6262 T9204 T9219 punct ;,al.
R6263 T9205 T9207 compound Hirose,al.
R6264 T9206 T9207 nmod et,al.
R6265 T9207 T9219 ccomp al.,al.
R6266 T9208 T9207 punct ",",al.
R6267 T9209 T9207 npadvmod 2001,al.
R6268 T9210 T9219 punct ;,al.
R6269 T9211 T9213 compound Squatrito,al.
R6270 T9212 T9213 compound et,al.
R6271 T9213 T9219 ccomp al.,al.
R6272 T9214 T9213 punct ",",al.
R6273 T9215 T9213 npadvmod 2010,al.
R6274 T9216 T9219 punct ;,al.
R6275 T9217 T9219 compound Blough,al.
R6276 T9218 T9219 compound et,al.
R6277 T9219 T9219 ROOT al.,al.
R6278 T9220 T9219 punct ",",al.
R6279 T9221 T9219 npadvmod 2011,al.
R6280 T9222 T9219 punct ),al.
R6281 T9223 T9219 punct .,al.
R6282 T9224 T9228 nsubj Loss,confers
R6283 T9225 T9224 prep of,Loss
R6284 T9226 T9227 amod functional,p53
R6285 T9227 T9225 pobj p53,of
R6286 T9228 T9228 ROOT confers,confers
R6287 T9229 T9228 dobj sensitivity,confers
R6288 T9230 T9229 prep to,sensitivity
R6289 T9231 T9230 pobj TMZ,to
R6290 T9232 T9228 prep in,confers
R6291 T9233 T9234 amod glioma,cells
R6292 T9234 T9232 pobj cells,in
R6293 T9235 T9228 punct ",",confers
R6294 T9236 T9240 mark whereas,increases
R6295 T9237 T9239 amod wild,p53
R6296 T9238 T9239 compound type,p53
R6297 T9239 T9240 nsubj p53,increases
R6298 T9240 T9228 advcl increases,confers
R6299 T9241 T9243 det the,resistance
R6300 T9242 T9243 compound TMZ,resistance
R6301 T9243 T9240 dobj resistance,increases
R6302 T9244 T9240 punct (,increases
R6303 T9245 T9247 amod Blough,al.
R6304 T9246 T9247 nmod et,al.
R6305 T9247 T9240 npadvmod al.,increases
R6306 T9248 T9247 punct ",",al.
R6307 T9249 T9247 npadvmod 2011,al.
R6308 T9250 T9240 punct ),increases
R6309 T9251 T9228 punct .,confers
R6310 T9252 T9253 compound p53,mutants
R6311 T9253 T9254 nsubj mutants,reduce
R6312 T9254 T9254 ROOT reduce,reduce
R6313 T9255 T9256 compound TMZ,sensitivity
R6314 T9256 T9254 dobj sensitivity,reduce
R6315 T9257 T9256 prep in,sensitivity
R6316 T9258 T9257 pobj gliomas,in
R6317 T9259 T9262 punct (,al.
R6318 T9260 T9262 amod Blough,al.
R6319 T9261 T9262 nmod et,al.
R6320 T9262 T9254 advmod al.,reduce
R6321 T9263 T9262 punct ",",al.
R6322 T9264 T9262 npadvmod 2011,al.
R6323 T9265 T9262 punct ),al.
R6324 T9266 T9254 punct .,reduce
R6325 T9267 T9269 amod Altered,expression
R6326 T9268 T9269 compound WWOX,expression
R6327 T9269 T9271 nsubjpass expression,shown
R6328 T9270 T9271 auxpass is,shown
R6329 T9271 T9271 ROOT shown,shown
R6330 T9272 T9271 prep in,shown
R6331 T9273 T9272 pobj GBMs,in
R6332 T9274 T9273 punct ",",GBMs
R6333 T9275 T9281 prep in,associated
R6334 T9276 T9275 pobj which,in
R6335 T9277 T9281 nsubjpass downregulation,associated
R6336 T9278 T9277 prep of,downregulation
R6337 T9279 T9278 pobj WWOX,of
R6338 T9280 T9281 auxpass is,associated
R6339 T9281 T9271 conj associated,shown
R6340 T9282 T9281 prep with,associated
R6341 T9283 T9282 pobj loss,with
R6342 T9284 T9283 prep of,loss
R6343 T9285 T9284 pobj heterozygosity,of
R6344 T9286 T9285 cc and,heterozygosity
R6345 T9287 T9288 compound promoter,methylation
R6346 T9288 T9285 conj methylation,heterozygosity
R6347 T9289 T9292 punct (,al.
R6348 T9290 T9292 compound Kosla,al.
R6349 T9291 T9292 nmod et,al.
R6350 T9292 T9283 appos al.,loss
R6351 T9293 T9292 punct ",",al.
R6352 T9294 T9292 npadvmod 2011,al.
R6353 T9295 T9281 punct ),associated
R6354 T9296 T9271 punct .,shown
R6355 T9297 T9300 advmod Recently,demonstrated
R6356 T9298 T9300 punct ",",demonstrated
R6357 T9299 T9300 nsubj we,demonstrated
R6358 T9300 T9300 ROOT demonstrated,demonstrated
R6359 T9301 T9304 mark that,induces
R6360 T9302 T9303 compound overexpressed,WWOX
R6361 T9303 T9304 nsubj WWOX,induces
R6362 T9304 T9300 ccomp induces,demonstrated
R6363 T9305 T9304 dobj apoptosis,induces
R6364 T9306 T9305 prep of,apoptosis
R6365 T9307 T9309 amod glioblastoma,cells
R6366 T9308 T9309 compound U373-MG,cells
R6367 T9309 T9306 pobj cells,of
R6368 T9310 T9309 acl harboring,cells
R6369 T9311 T9312 amod mutant,p53
R6370 T9312 T9310 dobj p53,harboring
R6371 T9313 T9310 prep by,harboring
R6372 T9314 T9313 pcomp causing,by
R6373 T9315 T9318 amod hypoploidy,fragmentation
R6374 T9316 T9315 cc and,hypoploidy
R6375 T9317 T9315 conj DNA,hypoploidy
R6376 T9318 T9314 dobj fragmentation,causing
R6377 T9319 T9322 punct (,al.
R6378 T9320 T9322 compound Chiang,al.
R6379 T9321 T9322 nmod et,al.
R6380 T9322 T9314 ccomp al.,causing
R6381 T9323 T9322 punct ",",al.
R6382 T9324 T9322 npadvmod 2012,al.
R6383 T9325 T9322 punct ),al.
R6384 T9326 T9300 punct .,demonstrated
R6385 T9327 T9331 advmod However,has
R6386 T9328 T9331 punct ",",has
R6387 T9329 T9330 compound ectopic,WWOX
R6388 T9330 T9331 nsubj WWOX,has
R6389 T9331 T9331 ROOT has,has
R6390 T9332 T9333 det no,effect
R6391 T9333 T9331 dobj effect,has
R6392 T9334 T9333 prep with,effect
R6393 T9335 T9336 nsubj U87-MG,expressing
R6394 T9336 T9334 pcomp expressing,with
R6395 T9337 T9339 amod wild,p53
R6396 T9338 T9339 compound type,p53
R6397 T9339 T9336 dobj p53,expressing
R6398 T9340 T9331 punct .,has
R6399 T9341 T9345 prep Unlike,induces
R6400 T9342 T9341 pobj TMZ,Unlike
R6401 T9343 T9345 punct ",",induces
R6402 T9344 T9345 nsubj WWOX,induces
R6403 T9345 T9345 ROOT induces,induces
R6404 T9346 T9345 dobj apoptosis,induces
R6405 T9347 T9346 prep of,apoptosis
R6406 T9348 T9349 compound U373-MG,cells
R6407 T9349 T9347 pobj cells,of
R6408 T9350 T9345 prep via,induces
R6409 T9351 T9355 det a,pathway
R6410 T9352 T9355 amod mitochondria-independent,pathway
R6411 T9353 T9352 cc and,mitochondria-independent
R6412 T9354 T9352 conj caspase-3-independent,mitochondria-independent
R6413 T9355 T9350 pobj pathway,via
R6414 T9356 T9359 punct (,al.
R6415 T9357 T9359 compound Chiang,al.
R6416 T9358 T9359 nmod et,al.
R6417 T9359 T9345 advcl al.,induces
R6418 T9360 T9359 punct ",",al.
R6419 T9361 T9359 npadvmod 2012,al.
R6420 T9362 T9359 punct ),al.
R6421 T9363 T9345 punct .,induces
R6422 T9364 T9368 mark While,are
R6423 T9365 T9367 det the,mechanisms
R6424 T9366 T9367 amod underlying,mechanisms
R6425 T9367 T9368 nsubj mechanisms,are
R6426 T9368 T9372 advcl are,is
R6427 T9369 T9368 acomp unknown,are
R6428 T9370 T9372 punct ",",is
R6429 T9371 T9372 nsubj it,is
R6430 T9372 T9372 ROOT is,is
R6431 T9373 T9372 acomp reasonable,is
R6432 T9374 T9375 aux to,assume
R6433 T9375 T9372 xcomp assume,is
R6434 T9376 T9383 mark that,depends
R6435 T9377 T9378 det the,survival
R6436 T9378 T9383 nsubj survival,depends
R6437 T9379 T9378 prep of,survival
R6438 T9380 T9382 amod human,cells
R6439 T9381 T9382 compound glioblastoma,cells
R6440 T9382 T9379 pobj cells,of
R6441 T9383 T9375 ccomp depends,assume
R6442 T9384 T9383 prep upon,depends
R6443 T9385 T9384 pobj interactions,upon
R6444 T9386 T9385 prep between,interactions
R6445 T9387 T9388 det the,gain-of-function
R6446 T9388 T9386 pobj gain-of-function,between
R6447 T9389 T9388 prep of,gain-of-function
R6448 T9390 T9391 compound p53,mutants
R6449 T9391 T9389 pobj mutants,of
R6450 T9392 T9391 cc and,mutants
R6451 T9393 T9391 conj WWOX,mutants
R6452 T9394 T9372 punct .,is
R6453 T9395 T9396 compound Activated,WWOX
R6454 T9396 T9397 nsubj WWOX,binds
R6455 T9397 T9397 ROOT binds,binds
R6456 T9398 T9399 amod wild,type
R6457 T9399 T9400 compound type,p53
R6458 T9400 T9397 dobj p53,binds
R6459 T9401 T9397 prep with,binds
R6460 T9402 T9403 compound Ser46,phosphorylation
R6461 T9403 T9401 pobj phosphorylation,with
R6462 T9404 T9407 punct (,al.
R6463 T9405 T9407 compound Chang,al.
R6464 T9406 T9407 nmod et,al.
R6465 T9407 T9407 ROOT al.,al.
R6466 T9408 T9407 punct ",",al.
R6467 T9409 T9407 amod 2005b,al.
R6468 T9410 T9409 punct ),2005b
R6469 T9411 T9407 punct .,al.
R6470 T9412 T9413 compound UV,irradiation
R6471 T9413 T9414 nsubj irradiation,enhances
R6472 T9414 T9414 ROOT enhances,enhances
R6473 T9415 T9417 det the,interactions
R6474 T9416 T9417 amod binding,interactions
R6475 T9417 T9414 dobj interactions,enhances
R6476 T9418 T9414 punct .,enhances
R6477 T9419 T9433 prep Despite,remains
R6478 T9420 T9421 det the,presence
R6479 T9421 T9419 pobj presence,Despite
R6480 T9422 T9421 prep of,presence
R6481 T9423 T9422 pobj Ser46,of
R6482 T9424 T9421 prep in,presence
R6483 T9425 T9424 pobj Δ40p53,in
R6484 T9426 T9433 punct ",",remains
R6485 T9427 T9433 nsubj binding,remains
R6486 T9428 T9427 prep of,binding
R6487 T9429 T9430 det this,protein
R6488 T9430 T9428 pobj protein,of
R6489 T9431 T9427 prep with,binding
R6490 T9432 T9431 pobj WWOX,with
R6491 T9433 T9433 ROOT remains,remains
R6492 T9434 T9436 aux to,determined
R6493 T9435 T9436 auxpass be,determined
R6494 T9436 T9433 xcomp determined,remains
R6495 T9437 T9433 punct .,remains
R6496 T9438 T9439 nsubj We,postulate
R6497 T9439 T9439 ROOT postulate,postulate
R6498 T9440 T9453 mark that,appear
R6499 T9441 T9453 prep in,appear
R6500 T9442 T9443 compound GBM,cells
R6501 T9443 T9441 pobj cells,in
R6502 T9444 T9453 punct ",",appear
R6503 T9445 T9447 preconj both,type
R6504 T9446 T9447 amod wild,type
R6505 T9447 T9453 nsubj type,appear
R6506 T9448 T9452 nmod p53,proteins
R6507 T9449 T9448 cc and,p53
R6508 T9450 T9448 conj ectopic,p53
R6509 T9451 T9452 compound WWOX,proteins
R6510 T9452 T9453 nsubj proteins,appear
R6511 T9453 T9439 ccomp appear,postulate
R6512 T9454 T9455 aux to,have
R6513 T9455 T9453 xcomp have,appear
R6514 T9456 T9458 det a,antagonism
R6515 T9457 T9458 amod functional,antagonism
R6516 T9458 T9455 dobj antagonism,have
R6517 T9459 T9455 punct ",",have
R6518 T9460 T9461 advmod thereby,nullifying
R6519 T9461 T9455 advcl nullifying,have
R6520 T9462 T9463 det each,other
R6521 T9463 T9464 poss other,function
R6522 T9464 T9461 dobj function,nullifying
R6523 T9465 T9464 prep in,function
R6524 T9466 T9465 pcomp inducing,in
R6525 T9467 T9466 dobj apoptosis,inducing
R6526 T9468 T9469 punct (,Figure
R6527 T9469 T9464 appos Figure,function
R6528 T9470 T9469 nummod 2,Figure
R6529 T9471 T9469 punct ),Figure
R6530 T9472 T9439 punct .,postulate
R6531 T9473 T9475 amod Mutant,proteins
R6532 T9474 T9475 compound p53,proteins
R6533 T9475 T9478 nsubj proteins,bind
R6534 T9476 T9478 aux can,bind
R6535 T9477 T9478 neg not,bind
R6536 T9478 T9478 ROOT bind,bind
R6537 T9479 T9480 compound ectopic,WWOX
R6538 T9480 T9478 dobj WWOX,bind
R6539 T9481 T9480 prep in,WWOX
R6540 T9482 T9483 compound GBM,cells
R6541 T9483 T9481 pobj cells,in
R6542 T9484 T9478 punct ",",bind
R6543 T9485 T9478 cc and,bind
R6544 T9486 T9487 nsubj WWOX,is
R6545 T9487 T9478 conj is,bind
R6546 T9488 T9487 acomp able,is
R6547 T9489 T9490 aux to,induce
R6548 T9490 T9488 xcomp induce,able
R6549 T9491 T9490 dobj apoptosis,induce
R6550 T9492 T9487 punct .,is
R6551 T9493 T9495 mark Whether,causes
R6552 T9494 T9495 nsubj WWOX,causes
R6553 T9495 T9502 advcl causes,is
R6554 T9496 T9495 dobj apoptosis,causes
R6555 T9497 T9495 prep in,causes
R6556 T9498 T9499 nsubj GBM,expressing
R6557 T9499 T9497 pcomp expressing,in
R6558 T9500 T9501 compound p53,isoforms
R6559 T9501 T9499 dobj isoforms,expressing
R6560 T9502 T9502 ROOT is,is
R6561 T9503 T9502 acomp unknown,is
R6562 T9504 T9502 cc and,is
R6563 T9505 T9502 conj remains,is
R6564 T9506 T9508 aux to,established
R6565 T9507 T9508 auxpass be,established
R6566 T9508 T9505 xcomp established,remains
R6567 T9509 T9502 punct .,is
R6629 T9985 T9987 mark Whether,affects
R6630 T9986 T9987 nsubj WWOX,affects
R6631 T9987 T9993 advcl affects,determined
R6632 T9988 T9989 compound TMZ,sensitivity
R6633 T9989 T9987 dobj sensitivity,affects
R6634 T9990 T9993 aux has,determined
R6635 T9991 T9993 neg never,determined
R6636 T9992 T9993 auxpass been,determined
R6637 T9993 T9993 ROOT determined,determined
R6638 T9994 T9993 punct .,determined
R6639 T9995 T9996 amod Binding,proteins
R6640 T9996 T10001 nsubj proteins,are
R6641 T9997 T9996 prep for,proteins
R6642 T9998 T9997 pobj WWOX,for
R6643 T9999 T9998 cc and/or,WWOX
R6644 T10000 T9998 conj p53,WWOX
R6645 T10001 T10001 ROOT are,are
R6646 T10002 T10001 acomp likely,are
R6647 T10003 T10004 aux to,affect
R6648 T10004 T10002 xcomp affect,likely
R6649 T10005 T10004 dobj apoptosis,affect
R6650 T10006 T10005 cc and,apoptosis
R6651 T10007 T10008 compound TMZ,sensitivity
R6652 T10008 T10005 conj sensitivity,apoptosis
R6653 T10009 T10008 prep in,sensitivity
R6654 T10010 T10011 compound GBM,cells
R6655 T10011 T10009 pobj cells,in
R6656 T10012 T10001 punct .,are
R6657 T10013 T10014 nsubj WWOX,binds
R6658 T10014 T10014 ROOT binds,binds
R6659 T10015 T10014 dobj MEK,binds
R6660 T10016 T10014 punct ",",binds
R6661 T10017 T10014 cc and,binds
R6662 T10018 T10020 mark that,dissociates
R6663 T10019 T10020 nsubj PMA,dissociates
R6664 T10020 T10014 conj dissociates,binds
R6665 T10021 T10022 det this,complex
R6666 T10022 T10020 dobj complex,dissociates
R6667 T10023 T10020 prep for,dissociates
R6668 T10024 T10023 pcomp causing,for
R7633 T11213 T11214 amod appropriate,chemicals
R7634 T11214 T11224 nsubjpass chemicals,expected
R7635 T11215 T11214 punct ",",chemicals
R7636 T11216 T11217 nsubj which,break
R7637 T11217 T11214 relcl break,chemicals
R7638 T11218 T11217 advmod apart,break
R7639 T11219 T11221 det the,complex
R7640 T11220 T11221 compound WWOX/MEK,complex
R7641 T11221 T11217 dobj complex,break
R7642 T11222 T11214 punct ",",chemicals
R7643 T11223 T11224 auxpass are,expected
R7644 T11224 T11224 ROOT expected,expected
R7645 T11225 T11226 aux to,cause
R7646 T11226 T11224 xcomp cause,expected
R7647 T11227 T11229 compound GBM,death
R7648 T11228 T11229 compound cell,death
R7649 T11229 T11226 dobj death,cause
R7650 T11230 T11224 punct .,expected
R7651 T11231 T11232 amod Preliminary,studies
R7652 T11232 T11239 nsubj studies,selected
R7653 T11233 T11232 prep from,studies
R7654 T11234 T11235 poss our,screening
R7655 T11235 T11233 pobj screening,from
R7656 T11236 T11235 prep of,screening
R7657 T11237 T11236 pobj chemicals,of
R7658 T11238 T11239 aux have,selected
R7659 T11239 T11239 ROOT selected,selected
R7660 T11240 T11242 amod certain,molecules
R7661 T11241 T11242 amod small,molecules
R7662 T11242 T11239 dobj molecules,selected
R7663 T11243 T11244 nsubj that,induce
R7664 T11244 T11242 relcl induce,molecules
R7665 T11245 T10024 dobj apoptosis,causing
R7666 T11246 T11245 prep of,apoptosis
R7667 T11247 T11249 compound T,cells
R7668 T11248 T11249 compound leukemia,cells
R7669 T11249 T11246 pobj cells,of
R7670 T11250 T11253 punct (,al.
R7671 T11251 T11253 compound Lin,al.
R7672 T11252 T11253 nmod et,al.
R7673 T11253 T11245 appos al.,apoptosis
R7674 T11254 T11253 punct ",",al.
R7675 T11255 T11253 npadvmod 2011,al.
R7676 T11256 T11253 punct ),al.
R7677 T11257 T10014 punct .,binds
R7678 T11258 T11224 advmod Thus,expected
R7679 T11259 T11224 punct ",",expected
R7793 T11599 T11244 dobj apoptosis,induce
R7794 T11600 T11599 prep of,apoptosis
R7795 T11601 T11602 amod many,types
R7796 T11602 T11600 pobj types,of
R7797 T11603 T11602 prep of,types
R7798 T11604 T11605 compound cancer,cells
R7799 T11605 T11603 pobj cells,of
R7800 T11606 T11609 punct (,al.
R7801 T11607 T11609 compound Lu,al.
R7802 T11608 T11609 nmod et,al.
R7803 T11609 T11242 appos al.,molecules
R7804 T11610 T11609 punct ",",al.
R7805 T11611 T11609 amod unpublished,al.
R7806 T11612 T11242 punct ),molecules
R7807 T11613 T11239 punct .,selected
R7808 T11614 T11622 advmod Indeed,enhances
R7809 T11615 T11622 punct ",",enhances
R7810 T11616 T11617 amod specific,inhibition
R7811 T11617 T11622 nsubj inhibition,enhances
R7812 T11618 T11617 prep of,inhibition
R7813 T11619 T11618 pobj MEK,of
R7814 T11620 T11617 prep by,inhibition
R7815 T11621 T11620 pobj selumetinib,by
R7816 T11622 T11622 ROOT enhances,enhances
R7817 T11623 T11626 amod TMZ-induced,death
R7818 T11624 T11625 compound cancer,cell
R7819 T11625 T11626 compound cell,death
R7820 T11626 T11622 dobj death,enhances
R7821 T11627 T11626 prep in,death
R7822 T11628 T11627 pobj vivo,in
R7823 T11629 T11632 punct (,al.
R7824 T11630 T11632 compound Holt,al.
R7825 T11631 T11632 nmod et,al.
R7826 T11632 T11622 npadvmod al.,enhances
R7827 T11633 T11632 punct ",",al.
R7828 T11634 T11632 npadvmod 2012,al.
R7829 T11635 T11632 punct ),al.
R7830 T11636 T11622 punct .,enhances
R7831 T11637 T11638 compound Serum,factors
R7832 T11638 T11641 nsubjpass factors,utilized
R7833 T11639 T11641 aux can,utilized
R7834 T11640 T11641 auxpass be,utilized
R7835 T11641 T11641 ROOT utilized,utilized
R7836 T11642 T11641 prep for,utilized
R7837 T11643 T11642 pcomp blocking,for
R7838 T11644 T11645 compound cancer,growth
R7839 T11645 T11643 dobj growth,blocking
R7840 T11646 T11641 punct .,utilized
R7841 T11647 T11653 prep For,induces
R7842 T11648 T11647 pobj example,For
R7843 T11649 T11653 punct ",",induces
R7844 T11650 T11651 compound serum,complement
R7845 T11651 T11653 nsubj complement,induces
R7846 T11652 T11653 nsubj C1q,induces
R7847 T11653 T11653 ROOT induces,induces
R7848 T11654 T11653 dobj apoptosis,induces
R7849 T11655 T11654 prep of,apoptosis
R7850 T11656 T11657 compound prostate,cancer
R7851 T11657 T11655 pobj cancer,of
R7852 T11658 T11657 cc and,cancer
R7853 T11659 T11660 amod neuroblastomas,cells
R7854 T11660 T11657 conj cells,cancer
R7855 T11661 T11653 prep without,induces
R7856 T11662 T11661 pobj participation,without
R7857 T11663 T11662 prep of,participation
R7858 T11664 T11665 amod downstream,proteins
R7859 T11665 T11663 pobj proteins,of
R7860 T11666 T11662 prep in,participation
R7861 T11667 T11670 det the,pathway
R7862 T11668 T11670 amod classical,pathway
R7863 T11669 T11670 compound activation,pathway
R7864 T11670 T11666 pobj pathway,in
R7865 T11671 T11674 punct (,al.
R7866 T11672 T11674 nmod Hong,al.
R7867 T11673 T11674 nmod et,al.
R7868 T11674 T11653 parataxis al.,induces
R7869 T11675 T11674 punct ",",al.
R7870 T11676 T11674 npadvmod 2009,al.
R7871 T11677 T11674 punct ),al.
R7872 T11678 T11653 punct .,induces
R7873 T11679 T11686 prep In,activated
R7874 T11680 T11681 det this,event
R7875 T11681 T11679 pobj event,In
R7876 T11682 T11686 punct ",",activated
R7877 T11683 T11684 compound ectopic,WWOX
R7878 T11684 T11686 nsubjpass WWOX,activated
R7879 T11685 T11686 auxpass is,activated
R7880 T11686 T11686 ROOT activated,activated
R7881 T11687 T11686 prep for,activated
R7882 T11688 T11687 pcomp inducing,for
R7883 T11689 T11688 dobj apoptosis,inducing
R7884 T11690 T11686 punct .,activated
R7885 T11691 T11705 nsubj Failure,is
R7886 T11692 T11691 prep of,Failure
R7887 T11693 T11694 compound ectopic,WWOX
R7888 T11694 T11692 pobj WWOX,of
R7889 T11695 T11691 prep in,Failure
R7890 T11696 T11695 pcomp inducing,in
R7891 T11697 T11696 dobj apoptosis,inducing
R7892 T11698 T11697 prep of,apoptosis
R7893 T11699 T11700 compound glioma,cells
R7894 T11700 T11698 pobj cells,of
R7895 T11701 T11696 conj possessing,inducing
R7896 T11702 T11703 amod wild,type
R7897 T11703 T11704 compound type,p53
R7898 T11704 T11701 dobj p53,possessing
R7899 T11705 T11705 ROOT is,is
R7900 T11706 T11705 acomp unusual,is
R7901 T11707 T11710 punct (,al.
R7902 T11708 T11710 compound Chiang,al.
R7903 T11709 T11710 nmod et,al.
R7904 T11710 T11705 prep al.,is
R7905 T11711 T11710 punct ",",al.
R7906 T11712 T11710 npadvmod 2012,al.
R7907 T11713 T11710 punct ),al.
R7908 T11714 T11705 punct .,is
R7909 T11715 T11721 prep In,shown
R7910 T11716 T11717 amod most,cases
R7911 T11717 T11715 pobj cases,In
R7912 T11718 T11721 punct ",",shown
R7913 T11719 T11721 nsubj we,shown
R7914 T11720 T11721 aux have,shown
R7915 T11721 T11721 ROOT shown,shown
R7916 T11722 T11725 mark that,interacts
R7917 T11723 T11725 nsubj p53,interacts
R7918 T11724 T11725 advmod functionally,interacts
R7919 T11725 T11721 ccomp interacts,shown
R7920 T11726 T11725 prep with,interacts
R7921 T11727 T11726 pobj WWOX,with
R7922 T11728 T11725 punct ",",interacts
R7923 T11729 T11721 cc and,shown
R7924 T11730 T11731 det both,proteins
R7925 T11731 T11732 nsubj proteins,induce
R7926 T11732 T11721 conj induce,shown
R7927 T11733 T11732 dobj apoptosis,induce
R7928 T11734 T11732 prep in,induce
R7929 T11735 T11737 det a,manner
R7930 T11736 T11737 amod synergistic,manner
R7931 T11737 T11734 pobj manner,in
R7932 T11738 T11759 punct (,al.
R7933 T11739 T11741 compound Chang,al.
R7934 T11740 T11741 nmod et,al.
R7935 T11741 T11759 ccomp al.,al.
R7936 T11742 T11741 punct ",",al.
R7937 T11743 T11741 nummod 2001,al.
R7938 T11744 T11743 punct ",",2001
R7939 T11745 T11743 conj 2003,2001
R7940 T11746 T11741 punct ",",al.
R7941 T11747 T11741 appos 2005a,al.
R7942 T11748 T11749 punct ",",b
R7943 T11749 T11741 conj b,al.
R7944 T11750 T11749 punct ",",b
R7945 T11751 T11749 npadvmod 2007,b
R7946 T11752 T11751 punct ",",2007
R7947 T11753 T11751 conj 2010,2007
R7948 T11754 T11753 punct ",",2010
R7949 T11755 T11753 conj 2012,2010
R7950 T11756 T11759 punct ;,al.
R7951 T11757 T11759 compound Su,al.
R7952 T11758 T11759 nmod et,al.
R7953 T11759 T11732 parataxis al.,induce
R7954 T11760 T11759 punct ",",al.
R7955 T11761 T11759 npadvmod 2012,al.
R7956 T11762 T11759 punct ),al.
R7957 T11763 T11721 punct .,shown
R7958 T11764 T11766 det A,scenario
R7959 T11765 T11766 amod likely,scenario
R7960 T11766 T11767 nsubj scenario,is
R7961 T11767 T11767 ROOT is,is
R7962 T11768 T11779 mark that,interfere
R7963 T11769 T11770 amod p53-binding,proteins
R7964 T11770 T11779 nsubj proteins,interfere
R7965 T11771 T11770 punct ",",proteins
R7966 T11772 T11773 nsubj which,are
R7967 T11773 T11770 relcl are,proteins
R7968 T11774 T11773 acomp present,are
R7969 T11775 T11774 prep in,present
R7970 T11776 T11775 pobj GBMs,in
R7971 T11777 T11770 punct ",",proteins
R7972 T11778 T11779 aux may,interfere
R7973 T11779 T11767 ccomp interfere,is
R7974 T11780 T11779 prep with,interfere
R7975 T11781 T11783 det the,function
R7976 T11834 T11833 prep during,upregulated
R7977 T11782 T11783 amod apoptotic,function
R7978 T11835 T11837 det the,stage
R7979 T11836 T11837 amod early,stage
R7980 T11783 T11780 pobj function,with
R7981 T11837 T11834 pobj stage,during
R7982 T11838 T11837 prep of,stage
R7983 T11839 T11840 compound cancer,progression
R7984 T11840 T11838 pobj progression,of
R7985 T11841 T11844 punct (,al.
R7986 T11784 T11783 prep of,function
R7987 T11842 T11844 compound Lai,al.
R7988 T11785 T11784 pobj WWOX,of
R7989 T11843 T11844 nmod et,al.
R7990 T11844 T11837 appos al.,stage
R7991 T11786 T11785 cc and,WWOX
R7992 T11845 T11844 punct ",",al.
R7993 T11846 T11844 npadvmod 2005,al.
R7994 T11847 T11844 punct ;,al.
R7995 T11787 T11785 conj p53,WWOX
R7996 T11848 T11850 compound Chang,al.
R7997 T11849 T11850 nmod et,al.
R7998 T11850 T11833 npadvmod al.,upregulated
R7999 T11788 T11767 punct .,is
R8000 T11851 T11850 punct ",",al.
R8001 T11852 T11850 amod unpublished,al.
R8002 T11789 T11790 amod Functional,antagonism
R8003 T11853 T11833 punct ),upregulated
R8004 T11854 T11805 punct .,is
R8005 T11855 T11858 aux Do,act
R8006 T11856 T11857 det these,proteins
R8007 T11790 T11797 nsubjpass antagonism,documented
R8008 T11857 T11858 nsubj proteins,act
R8009 T11858 T11858 ROOT act,act
R8010 T11791 T11790 prep among,antagonism
R8011 T11859 T11858 advmod synergistically,act
R8012 T11860 T11858 prep in,act
R8013 T11861 T11860 pcomp blocking,in
R8014 T11862 T11863 compound cancer,progression
R8015 T11792 T11793 compound tumor,suppressors
R8016 T11863 T11861 dobj progression,blocking
R8017 T11864 T11858 cc but,act
R8018 T11865 T11858 conj lose,act
R8019 T11793 T11791 pobj suppressors,among
R8020 T11866 T11865 dobj control,lose
R8021 T11867 T11858 advmod eventually,act
R8022 T11868 T11858 punct ?,act
R8023 T11794 T11797 aux has,documented
R8024 T11869 T11873 cc Or,counteract
R8025 T11870 T11873 punct ",",counteract
R8026 T11871 T11873 aux do,counteract
R8027 T11795 T11797 neg never,documented
R8028 T11872 T11873 nsubj they,counteract
R8029 T11873 T11873 ROOT counteract,counteract
R8030 T11874 T11875 det each,other
R8031 T11796 T11797 auxpass been,documented
R8032 T11875 T11876 poss other,function
R8033 T11876 T11873 dobj function,counteract
R8034 T11877 T11873 punct ",",counteract
R8035 T11878 T11879 advmod thus,allowing
R8036 T11879 T11873 advcl allowing,counteract
R8037 T11880 T11881 compound cancer,growth
R8038 T11797 T11797 ROOT documented,documented
R8039 T11881 T11879 dobj growth,allowing
R8040 T11882 T11873 punct ?,counteract
R8041 T11798 T11797 prep in,documented
R8042 T11883 T11886 mark Whether,counteracts
R8043 T11799 T11800 det the,literature
R8044 T11884 T11886 nsubj endogenous,counteracts
R8045 T11885 T11886 nsubj WWOX,counteracts
R8046 T11886 T11893 csubj counteracts,is
R8047 T11800 T11798 pobj literature,in
R8048 T11887 T11886 prep with,counteracts
R8049 T11888 T11889 det the,function
R8050 T11889 T11887 pobj function,with
R8051 T11890 T11889 prep of,function
R8052 T11801 T11797 punct .,documented
R8053 T11891 T11892 amod endogenous,p53
R8054 T11892 T11890 pobj p53,of
R8055 T11802 T11805 advmod However,is
R8056 T11893 T11893 ROOT is,is
R8057 T11894 T11893 acomp unknown,is
R8058 T11895 T11893 cc and,is
R8059 T11803 T11805 punct ",",is
R8060 T11896 T11893 conj remains,is
R8061 T11897 T11899 aux to,established
R8062 T11898 T11899 auxpass be,established
R8063 T11804 T11805 nsubj it,is
R8064 T11899 T11896 xcomp established,remains
R8065 T11900 T11893 punct .,is
R8066 T11805 T11805 ROOT is,is
R8067 T11901 T11909 nsubj One,is
R8068 T11902 T11901 prep of,One
R8069 T11903 T11905 det the,characteristics
R8070 T11904 T11905 amod unique,characteristics
R8071 T11806 T11807 neg not,surprising
R8072 T11905 T11902 pobj characteristics,of
R8073 T11906 T11905 prep for,characteristics
R8074 T11907 T11908 amod malignant,gliomas
R8075 T11807 T11805 acomp surprising,is
R8076 T11908 T11906 pobj gliomas,for
R8077 T11909 T11909 ROOT is,is
R8078 T11910 T11912 poss their,infiltration
R8079 T11911 T11912 compound diffuse,infiltration
R8080 T11808 T11809 aux to,find
R8081 T11912 T11909 attr infiltration,is
R8082 T11913 T11912 prep into,infiltration
R8083 T11914 T11916 amod distant,tissue
R8084 T11915 T11916 compound brain,tissue
R8085 T11916 T11913 pobj tissue,into
R8086 T11917 T11909 punct .,is
R8087 T11809 T11805 xcomp find,is
R8088 T11918 T11919 compound Signal,pathways
R8089 T11919 T11934 nsubjpass pathways,believed
R8090 T11920 T11919 punct ",",pathways
R8091 T11810 T11833 mark that,upregulated
R8092 T11921 T11919 acl involving,pathways
R8093 T11922 T11921 dobj PI3K,involving
R8094 T11923 T11922 punct ",",PI3K
R8095 T11811 T11814 amod many,proteins
R8096 T11924 T11922 conj Akt,PI3K
R8097 T11925 T11924 punct ",",Akt
R8098 T11926 T11924 conj mTOR,Akt
R8099 T11812 T11814 compound tumor,proteins
R8100 T11927 T11926 punct ",",mTOR
R8101 T11928 T11926 conj NF-κB,mTOR
R8102 T11929 T11928 punct ",",NF-κB
R8103 T11930 T11928 cc and,NF-κB
R8104 T11813 T11814 compound suppressor,proteins
R8105 T11814 T11833 nsubjpass proteins,upregulated
R8106 T11815 T11814 punct ",",proteins
R8107 T11931 T11928 conj autophagy,NF-κB
R8108 T11932 T11934 punct ",",believed
R8109 T11933 T11934 auxpass are,believed
R8110 T11816 T11814 conj e.g.,proteins
R8111 T11934 T11934 ROOT believed,believed
R8112 T11935 T11936 aux to,confer
R8113 T11936 T11934 xcomp confer,believed
R8114 T11937 T11939 det these,cells
R8115 T11817 T11816 punct ",",e.g.
R8116 T11938 T11939 amod migrating,cells
R8117 T11818 T11816 conj p53,e.g.
R8118 T11939 T11936 dobj cells,confer
R8119 T11940 T11936 advmod resistant,confer
R8120 T11941 T11940 prep to,resistant
R8121 T11942 T11943 amod apoptotic,death
R8122 T11819 T11818 punct ",",p53
R8123 T11943 T11941 pobj death,to
R8124 T11944 T11947 punct (,al.
R8125 T11945 T11947 nmod Lefranc,al.
R8126 T11946 T11947 nmod et,al.
R8127 T11820 T11818 conj WWOX,p53
R8128 T11947 T11936 advmod al.,confer
R8129 T11948 T11947 punct ",",al.
R8130 T11949 T11947 npadvmod 2005,al.
R8131 T11950 T11934 punct ),believed
R8132 T11821 T11820 punct ",",WWOX
R8133 T11951 T11934 punct .,believed
R8134 T11952 T11953 compound Glioma,cells
R8135 T11953 T11954 nsubj cells,possess
R8136 T11954 T11974 ccomp possess,al.
R8137 T11955 T11954 dobj CD44,possess
R8138 T11956 T11954 prep as,possess
R8139 T11822 T11820 conj Smad4,WWOX
R8140 T11957 T11958 det a,receptor
R8141 T11958 T11956 pobj receptor,as
R8142 T11959 T11958 prep for,receptor
R8143 T11960 T11959 pcomp interacting,for
R8144 T11823 T11822 punct ",",Smad4
R8145 T11961 T11960 prep with,interacting
R8146 T11824 T11822 conj PTEN,Smad4
R8147 T11962 T11964 compound brain,hyaluronan
R8148 T11825 T11824 punct ",",PTEN
R8149 T11963 T11964 compound matrix,hyaluronan
R8150 T11964 T11961 pobj hyaluronan,with
R8151 T11826 T11824 conj PP2A,PTEN
R8152 T11965 T11968 punct (,al.
R8153 T11966 T11968 compound Murai,al.
R8154 T11967 T11968 nmod et,al.
R8155 T11827 T11826 punct ",",PP2A
R8156 T11968 T11964 appos al.,hyaluronan
R8157 T11969 T11968 punct ",",al.
R8158 T11970 T11968 npadvmod 2004,al.
R8159 T11828 T11826 cc and,PP2A
R8160 T11971 T11974 punct ;,al.
R8161 T11972 T11974 compound Yoshida,al.
R8162 T11973 T11974 nmod et,al.
R8163 T11829 T11826 conj etc.,PP2A
R8164 T11974 T11974 ROOT al.,al.
R8165 T11975 T11974 punct ",",al.
R8166 T11976 T11974 npadvmod 2012,al.
R8167 T11830 T11833 punct ",",upregulated
R8168 T11977 T11974 punct ),al.
R8169 T11978 T11974 punct ",",al.
R8170 T11831 T11833 auxpass are,upregulated
R8171 T11979 T11974 cc and,al.
R8172 T11980 T11974 conj secrete,al.
R8173 T11981 T11980 dobj hyaluronidases,secrete
R8174 T11832 T11833 advmod significantly,upregulated
R8175 T11982 T11981 cc and,hyaluronidases
R8176 T11983 T11981 conj metalloproteinases,hyaluronidases
R8177 T11984 T11985 aux to,facilitate
R8178 T11833 T11809 ccomp upregulated,find
R8179 T11985 T11980 advcl facilitate,secrete
R8180 T11986 T11987 poss their,migration
R8181 T11987 T11985 dobj migration,facilitate
R8182 T12028 T12027 dobj migration,facilitates
R8183 T11988 T11991 punct (,al.
R8184 T11989 T11991 compound Delpech,al.
R8185 T11990 T11991 nmod et,al.
R8186 T11991 T11985 npadvmod al.,facilitate
R8187 T12029 T12028 prep of,migration
R8188 T11992 T11991 punct ",",al.
R8189 T11993 T11991 npadvmod 2002,al.
R8190 T11994 T11991 punct ;,al.
R8191 T11995 T11997 compound Junker,al.
R8192 T12030 T12031 compound ovarian,cancer
R8193 T11996 T11997 compound et,al.
R8194 T11997 T11991 conj al.,al.
R8195 T11998 T11997 punct ",",al.
R8196 T12031 T12029 pobj cancer,of
R8197 T11999 T11997 appos 2003,al.
R8198 T12000 T11985 punct ;,facilitate
R8199 T12001 T12003 compound Hagemann,al.
R8200 T12032 T12031 cc and,cancer
R8201 T12002 T12003 compound et,al.
R8202 T12003 T11980 conj al.,secrete
R8203 T12004 T12003 punct ",",al.
R8204 T12033 T12034 compound osteosarcoma,cells
R8205 T12005 T12003 npadvmod 2012,al.
R8206 T12006 T12003 punct ),al.
R8207 T12007 T11974 punct .,al.
R8208 T12008 T12015 advmod Also,expected
R8209 T12034 T12031 conj cells,cancer
R8210 T12009 T12015 punct ",",expected
R8211 T12010 T12015 nsubjpass lack,expected
R8212 T12011 T12010 prep of,lack
R8213 T12035 T12028 punct (,migration
R8214 T12012 T12013 compound WWOX,expression
R8215 T12013 T12011 pobj expression,of
R8216 T12036 T12038 compound Gourley,al.
R8217 T12014 T12015 auxpass is,expected
R8218 T12015 T12015 ROOT expected,expected
R8219 T12016 T12017 aux to,enhance
R8220 T12037 T12038 nmod et,al.
R8221 T12017 T12015 xcomp enhance,expected
R8222 T12018 T12019 compound cell,migration
R8223 T12038 T12028 appos al.,migration
R8224 T12019 T12017 dobj migration,enhance
R8225 T12020 T12015 punct .,expected
R8226 T12021 T12027 prep For,facilitates
R8227 T12039 T12038 punct ",",al.
R8228 T12022 T12021 pobj example,For
R8229 T12023 T12027 punct ",",facilitates
R8230 T12024 T12027 nsubj loss,facilitates
R8231 T12040 T12038 npadvmod 2009,al.
R8232 T12025 T12024 prep of,loss
R8233 T12026 T12025 pobj WWOX,of
R8234 T12027 T12045 ccomp facilitates,al.
R8235 T12041 T12045 punct ;,al.
R8236 T12042 T12043 compound Del,Mare
R8237 T12043 T12045 compound Mare,al.
R8238 T12125 T12131 prep In,migrate
R8239 T12044 T12045 nmod et,al.
R8240 T12126 T12125 pobj contrast,In
R8241 T12127 T12131 punct ",",migrate
R8242 T12128 T12130 amod wild,cells
R8243 T12045 T12045 ROOT al.,al.
R8244 T12129 T12130 compound type,cells
R8245 T12130 T12131 nsubj cells,migrate
R8246 T12131 T12131 ROOT migrate,migrate
R8247 T12046 T12045 punct ",",al.
R8248 T12132 T12131 advmod collectively,migrate
R8249 T12133 T12136 punct (,al.
R8250 T12047 T12045 npadvmod 2011,al.
R8251 T12134 T12136 compound Chou,al.
R8252 T12135 T12136 nmod et,al.
R8253 T12136 T12131 parataxis al.,migrate
R8254 T12137 T12136 punct ",",al.
R8255 T12048 T12045 punct ),al.
R8256 T12138 T12136 amod unpublished,al.
R8257 T12139 T12136 punct ),al.
R8258 T12140 T12131 punct .,migrate
R8259 T12049 T12045 punct .,al.
R8260 T12141 T12147 mark While,anchored
R8261 T12142 T12143 det a,portion
R8262 T12143 T12147 nsubjpass portion,anchored
R8263 T12050 T12051 amod Ectopic,expression
R8264 T12144 T12143 prep of,portion
R8265 T12145 T12144 pobj WWOX,of
R8266 T12146 T12147 auxpass is,anchored
R8267 T12147 T12155 advcl anchored,lose
R8268 T12051 T12051 ROOT expression,expression
R8269 T12148 T12147 prep on,anchored
R8270 T12052 T12051 prep of,expression
R8271 T12149 T12151 det the,membrane/cytoskeleton
R8272 T12150 T12151 compound cell,membrane/cytoskeleton
R8273 T12151 T12148 pobj membrane/cytoskeleton,on
R8274 T12053 T12052 pobj TIAF1,of
R8275 T12152 T12155 punct ",",lose
R8276 T12054 T12057 punct (,factor
R8277 T12153 T12154 amod WWOX-negative,cells
R8278 T12154 T12155 nsubj cells,lose
R8279 T12055 T12057 amod TGF-β-induced,factor
R8280 T12155 T12155 ROOT lose,lose
R8281 T12156 T12155 dobj recognition,lose
R8282 T12157 T12155 prep by,lose
R8283 T12158 T12160 amod parental,cells
R8284 T12159 T12160 amod WWOX-positive,cells
R8285 T12056 T12057 amod antiapoptotic,factor
R8286 T12160 T12157 pobj cells,by
R8287 T12161 T12155 punct ",",lose
R8288 T12162 T12155 cc and,lose
R8289 T12163 T12164 nsubj this,increases
R8290 T12057 T12051 appos factor,expression
R8291 T12164 T12155 conj increases,lose
R8292 T12165 T12166 det the,mobility
R8293 T12166 T12164 dobj mobility,increases
R8294 T12058 T12051 punct ),expression
R8295 T12167 T12166 prep of,mobility
R8296 T12168 T12169 amod WWOX-negative,cells
R8297 T12169 T12167 pobj cells,of
R8298 T12059 T12051 punct ",",expression
R8299 T12170 T12171 aux to,move
R8300 T12171 T12164 xcomp move,increases
R8301 T12172 T12171 advmod away,move
R8302 T12060 T12051 conj p53,expression
R8303 T12173 T12172 prep from,away
R8304 T12174 T12176 det the,cells
R8305 T12175 T12176 amod WWOX-positive,cells
R8306 T12061 T12060 punct ",",p53
R8307 T12176 T12173 pobj cells,from
R8308 T12177 T12164 punct .,increases
R8309 T12062 T12051 cc and,expression
R8310 T12063 T12064 nsubj WWOX,suppresses
R8311 T12178 T12183 advmod Conceivably,migrate
R8312 T12064 T12064 ROOT suppresses,suppresses
R8313 T12179 T12183 punct ",",migrate
R8314 T12180 T12182 amod WWOX-negative,cells
R8315 T12065 T12066 amod anchorage-independent,growth
R8316 T12066 T12064 dobj growth,suppresses
R8317 T12067 T12066 cc and,growth
R8318 T12181 T12182 compound glioma,cells
R8319 T12182 T12183 nsubj cells,migrate
R8320 T12068 T12069 compound cell,migration
R8321 T12183 T12183 ROOT migrate,migrate
R8322 T12184 T12183 advmod individually,migrate
R8323 T12185 T12183 cc and,migrate
R8324 T12186 T12183 conj turn,migrate
R8325 T12069 T12066 conj migration,growth
R8326 T12187 T12186 advmod away,turn
R8327 T12070 T12064 cc and,suppresses
R8328 T12188 T12187 prep from,away
R8329 T12189 T12191 amod WWOX-expressing,cells
R8330 T12190 T12191 compound brain,cells
R8331 T12191 T12188 pobj cells,from
R8332 T12071 T12064 conj causes,suppresses
R8333 T12192 T12186 prep to,turn
R8334 T12193 T12196 amod low,areas
R8335 T12194 T12196 compound WWOX,areas
R8336 T12072 T12071 dobj apoptosis,causes
R8337 T12195 T12196 compound expression,areas
R8338 T12073 T12071 prep in,causes
R8339 T12196 T12192 pobj areas,to
R8340 T12197 T12183 punct .,migrate
R8341 T12198 T12208 advmod Apparently,account
R8342 T12074 T12075 compound cancer,cells
R8343 T12199 T12208 punct ",",account
R8344 T12200 T12202 det the,behavior
R8345 T12201 T12202 amod migratory,behavior
R8346 T12075 T12073 pobj cells,in
R8347 T12202 T12208 nsubj behavior,account
R8348 T12203 T12202 prep of,behavior
R8349 T12076 T12079 punct (,al.
R8350 T12204 T12206 amod WWOX-negative,cells
R8351 T12205 T12206 compound glioma,cells
R8352 T12206 T12203 pobj cells,of
R8353 T12077 T12079 compound Chang,al.
R8354 T12207 T12208 aux may,account
R8355 T12208 T12208 ROOT account,account
R8356 T12209 T12208 prep for,account
R8357 T12078 T12079 nmod et,al.
R8358 T12210 T12212 det the,invasion
R8359 T12211 T12212 compound diffuse,invasion
R8360 T12212 T12209 pobj invasion,for
R8361 T12213 T12212 prep into,invasion
R8362 T12079 T12051 appos al.,expression
R8363 T12214 T12216 amod distant,tissue
R8364 T12215 T12216 compound brain,tissue
R8365 T12216 T12213 pobj tissue,into
R8366 T12080 T12079 punct ",",al.
R8367 T12217 T12212 punct (,invasion
R8368 T12218 T12220 compound Chou,al.
R8369 T12219 T12220 nmod et,al.
R8370 T12081 T12079 npadvmod 2012,al.
R8371 T12220 T12212 appos al.,invasion
R8372 T12221 T12220 punct ",",al.
R8373 T12082 T12079 punct ),al.
R8374 T12083 T12051 punct .,expression
R8375 T12222 T12220 amod unpublished,al.
R8376 T12084 T12085 nsubj We,believe
R8377 T12223 T12212 punct ),invasion
R8378 T12224 T12208 punct .,account
R8379 T12225 T12226 amod Metabolic,alterations
R8380 T12085 T12085 ROOT believe,believe
R8381 T12226 T12229 nsubjpass alterations,shown
R8382 T12086 T12095 mark that,migrate
R8383 T12227 T12229 aux have,shown
R8384 T12228 T12229 auxpass been,shown
R8385 T12229 T12229 ROOT shown,shown
R8386 T12230 T12229 prep in,shown
R8387 T12231 T12233 compound Wwox,mice
R8388 T12087 T12088 amod glioma,cells
R8389 T12232 T12233 compound knockout,mice
R8390 T12088 T12095 nsubj cells,migrate
R8391 T12233 T12230 pobj mice,in
R8392 T12234 T12233 punct ",",mice
R8393 T12235 T12233 prep including,mice
R8394 T12089 T12088 punct ",",cells
R8395 T12236 T12237 amod postnatal,lethality
R8396 T12237 T12235 pobj lethality,including
R8397 T12238 T12237 punct ",",lethality
R8398 T12090 T12088 prep with,cells
R8399 T12239 T12241 compound bone,defects
R8400 T12240 T12241 compound metabolism,defects
R8401 T12241 T12237 conj defects,lethality
R8402 T12091 T12093 compound stem,properties
R8403 T12242 T12241 punct ",",defects
R8404 T12243 T12241 conj ataxia,defects
R8405 T12244 T12243 punct ",",ataxia
R8406 T12092 T12093 compound cell-like,properties
R8407 T12245 T12243 conj steroidogenesis,ataxia
R8408 T12246 T12245 punct ",",steroidogenesis
R8409 T12247 T12245 cc and,steroidogenesis
R8410 T12093 T12090 pobj properties,with
R8411 T12248 T12245 conj generation,steroidogenesis
R8412 T12249 T12245 prep of,steroidogenesis
R8413 T12094 T12095 punct ",",migrate
R8414 T12250 T12249 pobj osteosarcomas,of
R8415 T12251 T12250 punct (,osteosarcomas
R8416 T12252 T12253 compound Del,Mare
R8417 T12095 T12085 ccomp migrate,believe
R8418 T12253 T12255 nmod Mare,al.
R8419 T12254 T12255 nmod et,al.
R8420 T12255 T12250 appos al.,osteosarcomas
R8421 T12096 T12095 advmod individually,migrate
R8422 T12256 T12255 punct ",",al.
R8423 T12257 T12255 npadvmod 2011,al.
R8424 T12258 T12250 punct ;,osteosarcomas
R8425 T12097 T12098 advmod rather,than
R8426 T12259 T12261 compound Salah,al.
R8427 T12260 T12261 nmod et,al.
R8428 T12261 T12250 conj al.,osteosarcomas
R8429 T12098 T12096 cc than,individually
R8430 T12262 T12261 punct ",",al.
R8431 T12263 T12261 npadvmod 2012,al.
R8432 T12099 T12096 conj collectively,individually
R8433 T12264 T12245 punct ),steroidogenesis
R8434 T12265 T12229 punct .,shown
R8435 T12266 T12273 prep In,shown
R8436 T12267 T12269 det a,model
R8437 T12268 T12269 compound Drosophila,model
R8438 T12269 T12266 pobj model,In
R8439 T12270 T12273 punct ",",shown
R8440 T12100 T12085 punct .,believe
R8441 T12271 T12273 nsubjpass Wwox,shown
R8442 T12272 T12273 auxpass is,shown
R8443 T12273 T12273 ROOT shown,shown
R8444 T12101 T12102 det This,assumption
R8445 T12102 T12104 nsubjpass assumption,based
R8446 T12274 T12275 aux to,participate
R8447 T12275 T12273 xcomp participate,shown
R8448 T12103 T12104 auxpass is,based
R8449 T12276 T12275 prep in,participate
R8450 T12277 T12276 pobj pathways,in
R8451 T12104 T12104 ROOT based,based
R8452 T12105 T12104 prep upon,based
R8453 T12278 T12277 acl involving,pathways
R8454 T12106 T12107 poss our,observations
R8455 T12279 T12280 amod aerobic,metabolism
R8456 T12280 T12278 dobj metabolism,involving
R8457 T12281 T12280 cc and,metabolism
R8458 T12107 T12105 pobj observations,upon
R8459 T12282 T12283 amod oxidative,stress
R8460 T12283 T12280 conj stress,metabolism
R8461 T12108 T12120 mark that,migrate
R8462 T12284 T12283 prep for,stress
R8463 T12285 T12284 pobj generation,for
R8464 T12286 T12285 prep of,generation
R8465 T12109 T12113 compound mouse,cells
R8466 T12287 T12286 pobj ROS,of
R8467 T12288 T12287 punct (,ROS
R8468 T12289 T12290 compound et,al.
R8469 T12110 T12113 compound Wwox,cells
R8470 T12290 T12287 appos al.,ROS
R8471 T12291 T12290 punct ",",al.
R8472 T12111 T12112 compound gene,knockout
R8473 T12292 T12290 npadvmod 2011,al.
R8474 T12293 T12287 punct ),ROS
R8475 T12294 T12273 punct .,shown
R8476 T12112 T12113 compound knockout,cells
R8477 T12295 T12303 prep Under,induces
R8478 T12296 T12297 compound UV,stress
R8479 T12297 T12295 pobj stress,Under
R8480 T12113 T12120 nsubj cells,migrate
R8481 T12298 T12303 punct ",",induces
R8482 T12299 T12302 amod functional,expression
R8483 T12114 T12113 punct (,cells
R8484 T12300 T12302 compound Wwox,expression
R8485 T12301 T12302 compound gene,expression
R8486 T12302 T12303 nsubj expression,induces
R8487 T12303 T12303 ROOT induces,induces
R8488 T12304 T12305 compound ROS,production
R8489 T12305 T12303 dobj production,induces
R8490 T12115 T12120 nsubj e.g.,migrate
R8491 T12306 T12305 prep in,production
R8492 T12307 T12306 pobj Drosophila,in
R8493 T12308 T12303 punct .,induces
R8494 T12309 T12310 compound Cancer,cells
R8495 T12116 T12118 punct ",",fibroblasts
R8496 T12117 T12118 amod embryonic,fibroblasts
R8497 T12310 T12312 nsubjpass cells,known
R8498 T12118 T12115 appos fibroblasts,e.g.
R8499 T12311 T12312 auxpass are,known
R8500 T12312 T12312 ROOT known,known
R8501 T12313 T12315 aux to,utilize
R8502 T12119 T12115 punct ),e.g.
R8503 T12314 T12315 advmod overly,utilize
R8504 T12315 T12312 xcomp utilize,known
R8505 T12316 T12315 dobj glycolysis,utilize
R8506 T12120 T12104 ccomp migrate,based
R8507 T12317 T12315 prep for,utilize
R8508 T12318 T12319 compound growth,advantage
R8509 T12121 T12120 advmod individually,migrate
R8510 T12122 T12121 cc and,individually
R8511 T12123 T12121 conj aggressively,individually
R8512 T12319 T12317 pobj advantage,for
R8513 T12124 T12104 punct .,based
R8514 T12320 T12322 det the,Warburg
R8515 T12321 T12322 amod so-called,Warburg
R8516 T12322 T12315 dobj Warburg,utilize
R8517 T12375 T12373 conj WWOX,p53
R8518 T12323 T12326 punct (,al.
R8519 T12376 T12369 prep in,role
R8520 T12324 T12326 nmod Moncada,al.
R8521 T12325 T12326 nmod et,al.
R8522 T12326 T12322 nummod al.,Warburg
R8523 T12377 T12376 pcomp regulating,in
R8524 T12327 T12326 punct ",",al.
R8525 T12328 T12326 npadvmod 2012,al.
R8526 T12329 T12326 punct ),al.
R8527 T12378 T12379 compound TMZ,sensitivity
R8528 T12330 T12312 punct .,known
R8529 T12331 T12334 advmod Conceivably,is
R8530 T12332 T12334 punct ",",is
R8531 T12333 T12334 nsubj WWOX,is
R8532 T12379 T12377 dobj sensitivity,regulating
R8533 T12334 T12334 ROOT is,is
R8534 T12335 T12334 acomp likely,is
R8535 T12336 T12337 aux to,override
R8536 T12337 T12335 xcomp override,likely
R8537 T12338 T12339 compound glucose,consumption
R8538 T12380 T12379 prep in,sensitivity
R8539 T12339 T12337 dobj consumption,override
R8540 T12340 T12337 prep in,override
R8541 T12341 T12342 compound cancer,cells
R8542 T12342 T12340 pobj cells,in
R8543 T12381 T12382 compound GBM,cells
R8544 T12343 T12334 cc and,is
R8545 T12344 T12345 compound exerts,generation
R8546 T12345 T12349 nsubj generation,curb
R8547 T12382 T12380 pobj cells,in
R8548 T12346 T12345 prep of,generation
R8549 T12347 T12346 pobj ROS,of
R8550 T12348 T12349 aux to,curb
R8551 T12383 T12366 punct .,discussed
R8552 T12349 T12334 conj curb,is
R8553 T12350 T12353 det the,growth
R8554 T12351 T12352 compound cancer,cell
R8555 T12384 T12386 nsubj We,shown
R8556 T12385 T12386 aux have,shown
R8557 T12352 T12353 compound cell,growth
R8558 T12386 T12386 ROOT shown,shown
R8559 T12353 T12349 dobj growth,curb
R8560 T12354 T12353 cc and,growth
R8561 T12387 T12388 det the,role
R8562 T12355 T12353 conj invasion,growth
R8563 T12356 T12334 punct .,is
R8564 T12357 T12366 prep In,discussed
R8565 T12358 T12357 pobj summary,In
R8566 T12388 T12386 dobj role,shown
R8567 T12359 T12366 punct ",",discussed
R8568 T12360 T12366 prep in,discussed
R8569 T12389 T12388 prep of,role
R8570 T12361 T12363 det this,article
R8571 T12362 T12363 compound perspective,article
R8572 T12363 T12360 pobj article,in
R8573 T12390 T12389 pobj WWOX,of
R8574 T12364 T12366 nsubj we,discussed
R8575 T12365 T12366 aux have,discussed
R8576 T12366 T12366 ROOT discussed,discussed
R8577 T12391 T12388 prep in,role
R8578 T12367 T12369 det the,role
R8579 T12368 T12369 amod potential,role
R8580 T12392 T12391 pcomp controlling,in
R8581 T12393 T12394 compound cell,migration
R8582 T12394 T12392 dobj migration,controlling
R8583 T12369 T12366 dobj role,discussed
R8584 T12395 T12394 cc and,migration
R8585 T12370 T12369 prep of,role
R8586 T12371 T12372 compound tumor,suppressors
R8587 T12372 T12373 compound suppressors,p53
R8588 T12373 T12370 pobj p53,of
R8589 T12374 T12373 cc and,p53
R8590 T12396 T12397 amod metabolic,alterations
R8591 T12397 T12394 conj alterations,migration
R8592 T12398 T12386 punct ",",shown
R8593 T12399 T12386 cc and,shown
R8594 T12400 T12386 conj discussed,shown
R8595 T12401 T12402 det the,effects
R8596 T12402 T12400 dobj effects,discussed
R8597 T12403 T12402 prep of,effects
R8598 T12404 T12405 compound WWOX,deficiency
R8599 T12405 T12403 pobj deficiency,of
R8600 T12406 T12405 cc and,deficiency
R8601 T12407 T12408 compound TMZ,resistance
R8602 T12408 T12405 conj resistance,deficiency
R8603 T12409 T12400 prep in,discussed
R8604 T12410 T12411 compound cancer,cells
R8605 T12411 T12409 pobj cells,in
R8606 T12412 T12386 punct .,shown
R8656 T12540 T12541 compound Ming-Fu,Chiang
R8657 T12541 T12545 nsubj Chiang,wrote
R8658 T12542 T12541 cc and,Chiang
R8659 T12543 T12544 compound Chun-I,Sze
R8660 T12544 T12541 conj Sze,Chiang
R8661 T12545 T12554 ccomp wrote,wrote
R8662 T12546 T12547 det the,sections
R8663 T12547 T12545 dobj sections,wrote
R8664 T12548 T12547 acl dealing,sections
R8665 T12549 T12548 prep with,dealing
R8666 T12550 T12549 pobj TMZ,with
R8667 T12551 T12554 punct ;,wrote
R8668 T12552 T12553 compound Pei-Yi,Chou
R8669 T12553 T12554 nsubj Chou,wrote
R8670 T12554 T12554 ROOT wrote,wrote
R8671 T12555 T12557 det the,sections
R8672 T12556 T12557 compound review,sections
R8673 T12557 T12554 dobj sections,wrote
R8674 T12558 T12557 prep for,sections
R8675 T12559 T12558 pobj p53,for
R8676 T12560 T12559 cc and,p53
R8677 T12561 T12559 conj WWOX,p53
R8678 T12562 T12561 cc and,WWOX
R8679 T12563 T12564 amod designed,graphs
R8680 T12564 T12561 conj graphs,WWOX
R8681 T12565 T12568 punct ;,managed
R8682 T12566 T12567 compound Wan-Jen,Wang
R8683 T12567 T12568 nsubj Wang,managed
R8684 T12568 T12573 ccomp managed,conceived
R8685 T12569 T12568 dobj citations,managed
R8686 T12570 T12573 punct ;,conceived
R8687 T12571 T12572 compound Nan-Shan,Chang
R8688 T12572 T12573 nsubj Chang,conceived
R8689 T12573 T12554 ccomp conceived,wrote
R8690 T12574 T12573 dobj ideas,conceived
R8691 T12575 T12573 punct ",",conceived
R8692 T12576 T12573 conj wrote,conceived
R8693 T12577 T12576 cc and,wrote
R8694 T12578 T12579 advmod thoroughly,revised
R8695 T12579 T12576 conj revised,wrote
R8696 T12580 T12581 det the,manuscript
R8697 T12581 T12579 dobj manuscript,revised
R8698 T12582 T12579 punct ",",revised
R8699 T12583 T12579 cc and,revised
R8700 T12584 T12579 conj discussed,revised
R8701 T12585 T12584 prep with,discussed
R8702 T12586 T12585 pobj coauthors,with
R8703 T12587 T12554 punct .,wrote
R8734 T12618 T12619 det The,authors
R8735 T12619 T12620 nsubj authors,declare
R8736 T12620 T12620 ROOT declare,declare
R8737 T12621 T12625 mark that,conducted
R8738 T12622 T12623 det the,research
R8739 T12623 T12625 nsubjpass research,conducted
R8740 T12624 T12625 auxpass was,conducted
R8741 T12625 T12620 ccomp conducted,declare
R8742 T12626 T12625 prep in,conducted
R8743 T12627 T12628 det the,absence
R8744 T12628 T12626 pobj absence,in
R8745 T12629 T12628 prep of,absence
R8746 T12630 T12631 det any,commercial
R8747 T12631 T12634 amod commercial,relationships
R8748 T12632 T12631 cc or,commercial
R8749 T12633 T12631 conj financial,commercial
R8750 T12634 T12629 pobj relationships,of
R8751 T12635 T12638 nsubjpass that,construed
R8752 T12636 T12638 aux could,construed
R8753 T12637 T12638 auxpass be,construed
R8754 T12638 T12634 relcl construed,relationships
R8755 T12639 T12638 prep as,construed
R8756 T12640 T12642 det a,conflict
R8757 T12641 T12642 amod potential,conflict
R8758 T12642 T12639 pobj conflict,as
R8759 T12643 T12642 prep of,conflict
R8760 T12644 T12643 pobj interest,of
R8761 T12645 T12620 punct .,declare
R8927 T12940 T13959 punct .,is
R8928 T12941 T12947 prep In,binds
R8929 T12942 T12941 pobj response,In
R8930 T12943 T12942 prep to,response
R8931 T12944 T12943 pobj TGF-β1,to
R8932 T12945 T12947 punct ",",binds
R8933 T12946 T12947 nsubj WWOX,binds
R8934 T12947 T12947 ROOT binds,binds
R8935 T12948 T12947 dobj Hyal-2,binds
R8936 T12949 T12948 cc and,Hyal-2
R8937 T12950 T12948 conj forms,Hyal-2
R8938 T12951 T12952 det a,complex
R8939 T12952 T12950 dobj complex,forms
R8940 T12953 T12950 punct ",",forms
R8941 T12954 T12947 advcl followed,binds
R8942 T12955 T12954 agent by,followed
R8943 T12956 T12955 pcomp relocating,by
R8944 T12957 T12956 prep to,relocating
R8945 T12958 T12959 det the,nucleus
R8946 T12959 T12957 pobj nucleus,to
R8947 T12960 T12956 cc and,relocating
R8948 T12961 T12956 conj enhancing,relocating
R8949 T12962 T12965 det the,activity
R8950 T12963 T12965 amod SMAD-driven,activity
R8951 T12964 T12965 compound promoter,activity
R8952 T12965 T12961 dobj activity,enhancing
R8953 T12966 T12947 punct .,binds
R8954 T12967 T12967 ROOT Ack1,Ack1
R8955 T12968 T12967 punct ",",Ack1
R8956 T12969 T12974 amod activated,Hyal-2
R8957 T12970 T12971 amod Cdc42-associated,kinase
R8958 T12971 T12969 dobj kinase,activated
R8959 T12972 T12971 nummod 1,kinase
R8960 T12973 T12969 punct ;,activated
R8961 T12974 T12967 conj Hyal-2,Ack1
R8962 T12975 T12974 punct ",",Hyal-2
R8963 T12976 T12979 nmod hyaluronoglucosaminidase,CKI
R8964 T12977 T12976 nummod 2,hyaluronoglucosaminidase
R8965 T12978 T12979 punct ;,CKI
R8966 T12979 T12974 conj CKI,Hyal-2
R8967 T12980 T12979 punct ",",CKI
R8968 T12981 T12982 compound casein,kinase
R8969 T12982 T12979 appos kinase,CKI
R8970 T12983 T12979 punct ;,CKI
R8971 T12984 T12979 conj GSK,CKI
R8972 T12985 T12984 punct ",",GSK
R8973 T12986 T12988 nmod glycogen,kinase
R8974 T12987 T12988 compound synthase,kinase
R8975 T12988 T12984 appos kinase,GSK
R8976 T12989 T12984 punct ;,GSK
R8977 T12990 T12984 conj PKA,GSK
R8978 T12991 T12990 punct ",",PKA
R8979 T12992 T12994 compound protein,A.
R8980 T12993 T12994 compound kinase,A.
R8981 T12994 T12990 appos A.,PKA
R9379 T13557 T13558 amod Schematic,diagrams
R9380 T13558 T13558 ROOT diagrams,diagrams
R9381 T13559 T13558 prep of,diagrams
R9382 T13560 T13561 compound WWOX,structure
R9383 T13561 T13559 pobj structure,of
R9384 T13562 T13558 cc and,diagrams
R9385 T13563 T13564 poss its,role
R9386 T13564 T13558 conj role,diagrams
R9387 T13565 T13564 prep in,role
R9388 T13566 T13565 pcomp signaling,in
R9389 T13567 T13558 punct .,diagrams
R9390 T13568 T13569 nsubj WWOX,contains
R9391 T13569 T13569 ROOT contains,contains
R9392 T13570 T13573 nummod two,domains
R9393 T13571 T13573 amod N-terminal,domains
R9394 T13572 T13573 compound WW,domains
R9395 T13573 T13569 dobj domains,contains
R9396 T13574 T13573 punct ",",domains
R9397 T13575 T13579 det a,dehydrogenase/reductase
R9398 T13576 T13579 amod C-terminal,dehydrogenase/reductase
R9399 T13577 T13579 compound short-chain,dehydrogenase/reductase
R9400 T13578 T13579 compound alcohol,dehydrogenase/reductase
R9401 T13579 T13573 appos dehydrogenase/reductase,domains
R9402 T13580 T13581 punct (,SDR
R9403 T13581 T13579 appos SDR,dehydrogenase/reductase
R9404 T13582 T13581 punct ),SDR
R9405 T13583 T13579 conj domain,dehydrogenase/reductase
R9406 T13584 T13583 punct ",",domain
R9407 T13585 T13583 cc and,domain
R9408 T13586 T13588 det a,region
R9409 T13587 T13588 amod D3,region
R9410 T13588 T13583 conj region,domain
R9411 T13589 T13569 punct .,contains
R9412 T13590 T13593 det A,signal
R9413 T13591 T13592 amod nuclear,localization
R9414 T13592 T13593 compound localization,signal
R9415 T13593 T13597 nsubj signal,is
R9416 T13594 T13593 punct (,signal
R9417 T13595 T13593 appos NLS,signal
R9418 T13596 T13593 punct ),signal
R9419 T13597 T13776 ccomp is,al.
R9420 T13598 T13597 prep in,is
R9421 T13599 T13598 prep between,in
R9422 T13600 T13602 det the,domains
R9423 T13601 T13602 compound WW,domains
R9424 T13602 T13599 pobj domains,between
R9425 T13603 T13606 punct (,al.
R9426 T13604 T13606 compound Chang,al.
R9427 T13605 T13606 nmod et,al.
R9428 T13606 T13776 ccomp al.,al.
R9429 T13607 T13606 punct ",",al.
R9430 T13608 T13606 appos 2003,al.
R9431 T13609 T13608 punct ",",2003
R9432 T13610 T13608 conj 2007,2003
R9433 T13611 T13776 punct ;,al.
R9434 T13612 T13613 compound Del,Mare
R9435 T13613 T13615 compound Mare,al.
R9436 T13614 T13615 nmod et,al.
R9437 T13615 T13776 ccomp al.,al.
R9438 T13616 T13615 punct ",",al.
R9439 T13617 T13615 npadvmod 2011,al.
R9440 T13618 T13615 punct ;,al.
R9441 T13619 T13621 compound Salah,al.
R9442 T13620 T13621 nmod et,al.
R9443 T13621 T13615 conj al.,al.
R9444 T13622 T13621 punct ",",al.
R9445 T13623 T13621 npadvmod 2012,al.
R9446 T13624 T13776 punct ;,al.
R9447 T13625 T13776 compound Su,al.
R9448 T13626 T13776 nmod et,al.
R9492 T13776 T13776 ROOT al.,al.
R9493 T13777 T13776 punct ",",al.
R9494 T13778 T13776 npadvmod 2012,al.
R9495 T13779 T13780 punct ;,reviews
R9496 T13780 T13776 appos reviews,al.
R9497 T13781 T13780 punct ),reviews
R9498 T13782 T13776 punct .,al.
R9499 T13783 T13785 det The,domain
R9500 T13784 T13785 compound SDR,domain
R9501 T13785 T13786 nsubj domain,possesses
R9502 T13786 T13786 ROOT possesses,possesses
R9503 T13787 T13789 det a,region
R9504 T13788 T13789 amod mitochondria-binding,region
R9505 T13789 T13786 dobj region,possesses
R9506 T13790 T13786 punct .,possesses
R9507 T13791 T13792 expl There,are
R9508 T13792 T13792 ROOT are,are
R9509 T13793 T13797 nummod two,sites
R9510 T13794 T13797 amod conserved,sites
R9511 T13795 T13797 amod tyrosine,sites
R9512 T13796 T13797 compound phosphorylation,sites
R9513 T13797 T13792 attr sites,are
R9514 T13798 T13797 punct ",",sites
R9515 T13799 T13797 appos Tyr33,sites
R9516 T13800 T13799 cc and,Tyr33
R9517 T13801 T13799 conj Tyr287,Tyr33
R9518 T13802 T13792 punct .,are
R9519 T13803 T13805 amod Other,sites
R9520 T13804 T13805 compound phosphorylation,sites
R9521 T13805 T13811 nsubj sites,are
R9522 T13806 T13805 acl predicted,sites
R9523 T13807 T13806 agent by,predicted
R9524 T13808 T13810 nmod NetPhos,Server
R9525 T13809 T13810 nummod 2.0,Server
R9526 T13810 T13807 pobj Server,by
R9527 T13811 T13811 ROOT are,are
R9528 T13812 T13811 attr Tyr6,are
R9529 T13813 T13812 punct ",",Tyr6
R9530 T13814 T13812 conj Thr12,Tyr6
R9531 T13815 T13814 punct ",",Thr12
R9532 T13816 T13814 conj Ser14,Thr12
R9533 T13817 T13816 punct ",",Ser14
R9534 T13818 T13816 conj Tyr61,Ser14
R9535 T13819 T13818 punct ",",Tyr61
R9536 T13820 T13818 conj Tyr293,Tyr61
R9537 T13821 T13820 punct ",",Tyr293
R9538 T13822 T13820 cc and,Tyr293
R9539 T13823 T13820 conj Thr3B3,Tyr293
R9540 T13824 T13823 punct ",",Thr3B3
R9541 T13825 T13811 advmod respectively,are
R9542 T13826 T13811 punct .,are
R9543 T13827 T13833 prep Upon,phosphorylated
R9544 T13828 T13829 compound stress,stimulation
R9545 T13829 T13827 pobj stimulation,Upon
R9546 T13830 T13833 punct ",",phosphorylated
R9547 T13831 T13832 nsubj WWOX,is
R9548 T13832 T13833 auxpass is,phosphorylated
R9549 T13833 T13833 ROOT phosphorylated,phosphorylated
R9550 T13834 T13833 prep in,phosphorylated
R9551 T13835 T13834 pobj Tyr33,in
R9552 T13836 T13833 cc and,phosphorylated
R9553 T13837 T13833 conj binds,phosphorylated
R9554 T13838 T13837 dobj p53,binds
R9555 T13839 T13833 punct .,phosphorylated
R9556 T13840 T13842 det The,complex
R9557 T13841 T13842 amod WWOX/p53,complex
R9558 T13842 T13844 nsubj complex,translocates
R9559 T13843 T13844 advmod then,translocates
R9560 T13844 T13844 ROOT translocates,translocates
R9561 T13845 T13846 aux to,mitochondria
R9562 T13846 T13844 xcomp mitochondria,translocates
R9563 T13847 T13846 cc or,mitochondria
R9564 T13848 T13846 conj nucleus,mitochondria
R9565 T13849 T13850 aux to,induce
R9566 T13850 T13848 advcl induce,nucleus
R9567 T13851 T13850 dobj apoptosis,induce
R9568 T13852 T13844 punct .,translocates
R9569 T13853 T13855 nsubj WWOX,binds
R9570 T13854 T13855 advmod also,binds
R9571 T13855 T13855 ROOT binds,binds
R9572 T13856 T13859 compound PPxY,factors
R9573 T13857 T13858 compound motif-containing,transcription
R9574 T13858 T13859 compound transcription,factors
R9575 T13859 T13855 dobj factors,binds
R9576 T13860 T13859 punct ",",factors
R9577 T13861 T13862 amod such,as
R9578 T13862 T13859 prep as,factors
R9579 T13863 T13862 pobj RUNX2,as
R9580 T13864 T13863 punct ",",RUNX2
R9581 T13865 T13863 conj c-Jun,RUNX2
R9582 T13866 T13865 punct ",",c-Jun
R9583 T13867 T13865 cc and,c-Jun
R9584 T13868 T13865 conj ERBB4,c-Jun
R9585 T13869 T13859 punct ",",factors
R9586 T13870 T13855 prep via,binds
R9587 T13871 T13874 poss its,domain
R9588 T13872 T13874 amod first,domain
R9589 T13873 T13874 compound WW,domain
R9590 T13874 T13870 pobj domain,via
R9591 T13875 T13855 punct ",",binds
R9592 T13876 T13855 cc and,binds
R9593 T13877 T13879 det the,blocks
R9594 T13878 T13879 amod binding,blocks
R9595 T13879 T13855 conj blocks,binds
R9596 T13880 T13881 det the,activity
R9597 T13881 T13879 dobj activity,blocks
R9598 T13882 T13881 prep of,activity
R9599 T13883 T13884 det these,proteins
R9600 T13884 T13882 pobj proteins,of
R9601 T13885 T13879 prep by,blocks
R9602 T13886 T13885 pcomp retaining,by
R9603 T13887 T13886 dobj them,retaining
R9604 T13888 T13886 prep in,retaining
R9605 T13889 T13890 det the,cytoplasm
R9606 T13890 T13888 pobj cytoplasm,in
R9607 T13891 T13855 punct .,binds
R9608 T13892 T13893 nsubj WWOX,binds
R9609 T13893 T13893 ROOT binds,binds
R9610 T13894 T13893 dobj Tau,binds
R9611 T13895 T13893 prep via,binds
R9612 T13896 T13898 poss its,domain
R9613 T13897 T13898 compound SDR,domain
R9614 T13898 T13895 pobj domain,via
R9615 T13899 T13893 punct .,binds
R9616 T13900 T13901 nsubj WWOX,participates
R9617 T13901 T13901 ROOT participates,participates
R9618 T13902 T13901 prep in,participates
R9619 T13903 T13908 det the,pathway
R9620 T13904 T13908 nmod Wnt,pathway
R9621 T13905 T13908 nmod /,pathway
R9622 T13906 T13908 amod β-catenin,pathway
R9623 T13907 T13908 compound signal,pathway
R9624 T13908 T13902 pobj pathway,in
R9625 T13909 T13901 prep by,participates
R9626 T13910 T13911 amod binding,Dvl
R9627 T13911 T13909 pobj Dvl,by
R9628 T13912 T13901 cc and,participates
R9629 T13913 T13901 conj inhibiting,participates
R9630 T13914 T13916 poss its,import
R9631 T13915 T13916 amod nuclear,import
R9632 T13916 T13913 dobj import,inhibiting
R9633 T13917 T13901 punct .,participates
R9634 T13918 T13919 compound Phorbol,ester
R9635 T13919 T13920 nsubj ester,stimulates
R9636 T13920 T13920 ROOT stimulates,stimulates
R9637 T13921 T13922 det the,dissociation
R9638 T13922 T13920 dobj dissociation,stimulates
R9639 T13923 T13922 prep of,dissociation
R9640 T13924 T13925 compound MEK/WWOX,complex
R9641 T13925 T13923 pobj complex,of
R9642 T13926 T13922 prep in,dissociation
R9643 T13927 T13928 compound Jurkat,T
R9644 T13928 T13929 compound T,cell
R9645 T13929 T13926 pobj cell,in
R9646 T13930 T13920 punct ",",stimulates
R9647 T13931 T13920 cc and,stimulates
R9648 T13932 T13935 det the,translocates
R9649 T13933 T13935 amod released,translocates
R9650 T13934 T13935 compound WWOX,translocates
R9651 T13935 T13920 conj translocates,stimulates
R9652 T13936 T13935 prep to,translocates
R9653 T13937 T13938 det the,mitochondria
R9654 T13938 T13936 pobj mitochondria,to
R9655 T13939 T13935 prep for,translocates
R9656 T13940 T13939 pcomp causing,for
R9657 T13941 T13942 compound cell,death
R9658 T13942 T13940 dobj death,causing
R9659 T13943 T13920 punct .,stimulates
R9660 T13944 T13946 nsubjpass WWOX,recruited
R9661 T13945 T13946 auxpass is,recruited
R9662 T13946 T13946 ROOT recruited,recruited
R9663 T13947 T13946 prep to,recruited
R9664 T13948 T13950 det the,area
R9665 T13949 T13950 compound membrane,area
R9666 T13950 T13947 pobj area,to
R9667 T13951 T13946 agent by,recruited
R9668 T13952 T13951 pobj association,by
R9669 T13953 T13952 prep with,association
R9670 T13954 T13953 pobj Hyal-2,with
R9671 T13955 T13954 cc and,Hyal-2
R9672 T13956 T13954 conj phospho-Ezrin,Hyal-2
R9673 T13957 T13946 punct .,recruited
R9674 T13958 T13959 nsubj Hyal-2,is
R9675 T13959 T13959 ROOT is,is
R9676 T13960 T13962 det an,receptor
R9677 T13961 T13962 amod alternative,receptor
R9678 T13962 T13959 attr receptor,is
R9679 T13963 T13962 prep for,receptor
R9680 T13964 T13963 pobj TGF-β1,for
R9951 T14525 T14525 ROOT p53,p53
R9952 T14526 T14525 cc and,p53
R9953 T14527 T14525 conj WWOX,p53
R9954 T14528 T14527 prep in,WWOX
R9955 T14529 T14531 compound GBM,apoptosis
R9956 T14530 T14531 compound cell,apoptosis
R9957 T14531 T14528 pobj apoptosis,in
R9958 T14532 T14525 punct .,p53
R9959 T14533 T14538 punct (,possesses
R9960 T14534 T14537 det A,p53
R9961 T14535 T14537 punct ),p53
R9962 T14536 T14537 amod Full-length,p53
R9963 T14537 T14538 nsubj p53,possesses
R9964 T14538 T14538 ROOT possesses,possesses
R9965 T14539 T14543 nummod two,domains
R9966 T14540 T14543 amod N-terminal,domains
R9967 T14541 T14543 amod transactivation,domains
R9968 T14542 T14543 amod acidic,domains
R9969 T14543 T14538 dobj domains,possesses
R9970 T14544 T14543 punct ",",domains
R9971 T14545 T14547 det a,domain
R9972 T14546 T14547 amod proline-rich,domain
R9973 T14547 T14543 appos domain,domains
R9974 T14548 T14547 punct ",",domain
R9975 T14549 T14552 det a,region
R9976 T14550 T14552 amod central,region
R9977 T14551 T14552 amod DNA-binding,region
R9978 T14552 T14547 conj region,domain
R9979 T14553 T14547 punct ",",domain
R9980 T14554 T14547 cc and,domain
R9981 T14555 T14557 det a,domain
R9982 T14556 T14557 amod C-terminal,domain
R9983 T14557 T14547 conj domain,domain
R9984 T14558 T14557 punct ",",domain
R9985 T14559 T14557 acl containing,domain
R9986 T14560 T14563 det a,signal
R9987 T14561 T14562 amod nuclear,localization
R9988 T14562 T14563 compound localization,signal
R9989 T14563 T14559 dobj signal,containing
R9990 T14564 T14563 punct ",",signal
R9991 T14565 T14567 det an,domain
R9992 T14566 T14567 compound oligomerization,domain
R9993 T14567 T14563 conj domain,signal
R9994 T14568 T14567 punct ",",domain
R9995 T14569 T14567 cc and,domain
R9996 T14570 T14572 det a,region
R9997 T14571 T14572 amod basic,region
R9998 T14572 T14567 conj region,domain
R9999 T14573 T14538 punct .,possesses