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PMC:3586680 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T552 0-5 NNP denotes Tumor
T553 6-16 NNP denotes Suppressor
T554 17-21 NNP denotes WWOX
T555 22-25 CC denotes and
T556 26-29 NN denotes p53
T557 30-41 NNS denotes Alterations
T558 42-45 CC denotes and
T559 46-50 NN denotes Drug
T560 51-61 NN denotes Resistance
T561 62-64 IN denotes in
T562 65-78 NNP denotes Glioblastomas
T563 89-94 NNP denotes Tumor
T564 95-105 NN denotes suppressor
T565 106-109 NN denotes p53
T566 110-113 VBP denotes are
T567 114-124 RB denotes frequently
T568 125-132 VBN denotes mutated
T569 133-135 IN denotes in
T570 136-149 NNS denotes glioblastomas
T571 150-151 -LRB- denotes (
T572 151-155 NNS denotes GBMs
T573 155-156 -RRB- denotes )
T574 157-160 CC denotes and
T575 161-168 VBZ denotes appears
T576 169-171 TO denotes to
T577 172-182 VB denotes contribute
T578 182-183 , denotes ,
T579 184-186 IN denotes in
T580 187-191 NN denotes part
T581 191-192 , denotes ,
T582 193-195 TO denotes to
T583 196-206 NN denotes resistance
T584 207-209 TO denotes to
T585 210-222 VB denotes temozolomide
T586 223-224 -LRB- denotes (
T587 224-227 NNP denotes TMZ
T588 227-228 -RRB- denotes )
T589 229-232 CC denotes and
T590 233-244 JJ denotes therapeutic
T591 245-250 NNS denotes drugs
T592 250-251 . denotes .
T593 252-254 NNP denotes WW
T594 255-272 JJ denotes domain-containing
T595 273-287 NN denotes oxidoreductase
T596 288-292 NNP denotes WWOX
T597 293-294 -LRB- denotes (
T598 294-297 IN denotes FOR
T599 298-300 CC denotes or
T600 301-305 CD denotes WOX1
T601 305-306 -RRB- denotes )
T602 307-309 VBZ denotes is
T603 310-311 DT denotes a
T604 312-324 JJ denotes proapoptotic
T605 325-332 NN denotes protein
T606 333-336 CC denotes and
T607 337-339 VBZ denotes is
T608 340-350 VBN denotes considered
T609 351-353 IN denotes as
T610 354-355 DT denotes a
T611 356-361 NN denotes tumor
T612 362-372 NN denotes suppressor
T613 372-373 . denotes .
T614 374-378 NN denotes Loss
T615 379-381 IN denotes of
T616 382-386 NNP denotes WWOX
T617 387-391 NN denotes gene
T618 392-402 NN denotes expression
T619 403-405 VBZ denotes is
T620 406-416 RB denotes frequently
T621 417-421 VBN denotes seen
T622 422-424 IN denotes in
T623 425-434 JJ denotes malignant
T624 435-441 NN denotes cancer
T625 442-447 NNS denotes cells
T626 448-451 JJ denotes due
T627 452-454 TO denotes to
T628 455-463 NN denotes promoter
T629 464-480 NN denotes hypermethylation
T630 480-481 , denotes ,
T631 482-489 JJ denotes genetic
T632 490-501 NNS denotes alterations
T633 501-502 , denotes ,
T634 503-506 CC denotes and
T635 507-520 JJ denotes translational
T636 521-529 NN denotes blockade
T637 529-530 . denotes .
T638 531-543 RB denotes Intriguingly
T639 543-544 , denotes ,
T640 545-552 JJ denotes ectopic
T641 553-563 NN denotes expression
T642 564-566 IN denotes of
T643 567-571 JJ denotes wild
T644 572-576 NN denotes type
T645 577-581 NNP denotes WWOX
T646 582-596 RB denotes preferentially
T647 597-604 VBZ denotes induces
T648 605-614 NN denotes apoptosis
T649 615-617 IN denotes in
T650 618-623 JJ denotes human
T651 624-636 NN denotes glioblastoma
T652 637-642 NNS denotes cells
T653 643-652 VBG denotes harboring
T654 653-659 JJ denotes mutant
T655 660-663 NN denotes p53
T656 663-664 . denotes .
T657 665-669 NNP denotes WWOX
T658 670-672 VBZ denotes is
T659 673-678 VBN denotes known
T660 679-681 TO denotes to
T661 682-692 RB denotes physically
T662 693-697 NN denotes bind
T663 698-701 CC denotes and
T664 702-711 VB denotes stabilize
T665 712-716 JJ denotes wild
T666 717-721 NN denotes type
T667 722-725 NN denotes p53
T668 725-726 . denotes .
T669 727-731 RB denotes Here
T670 731-732 , denotes ,
T671 733-735 PRP denotes we
T672 736-743 VBP denotes provide
T673 744-746 DT denotes an
T674 747-755 NN denotes overview
T675 756-759 IN denotes for
T676 760-763 DT denotes the
T677 764-771 VBN denotes updated
T678 772-781 NN denotes knowledge
T679 782-784 IN denotes in
T680 785-788 NN denotes p53
T681 789-792 CC denotes and
T682 793-797 NNP denotes WWOX
T683 797-798 , denotes ,
T684 799-802 CC denotes and
T685 803-812 VB denotes postulate
T686 813-822 JJ denotes potential
T687 823-832 NNS denotes scenarios
T688 833-837 WDT denotes that
T689 838-842 JJ denotes wild
T690 843-847 NN denotes type
T691 848-851 CC denotes and
T692 852-858 JJ denotes mutant
T693 859-862 NN denotes p53
T694 862-863 , denotes ,
T695 864-866 CC denotes or
T696 867-875 NNS denotes isoforms
T697 875-876 , denotes ,
T698 877-885 VBP denotes modulate
T699 886-889 DT denotes the
T700 890-899 JJ denotes apoptotic
T701 900-908 NN denotes function
T702 909-911 IN denotes of
T703 912-916 NNP denotes WWOX
T704 916-917 . denotes .
T705 918-920 PRP denotes We
T706 921-928 VBP denotes propose
T707 929-933 IN denotes that
T708 934-944 VBG denotes triggering
T709 945-949 NNP denotes WWOX
T710 950-960 NN denotes activation
T711 961-963 IN denotes by
T712 964-975 JJ denotes therapeutic
T713 976-981 NNS denotes drugs
T714 982-987 IN denotes under
T715 988-991 NN denotes p53
T716 992-1002 JJ denotes functional
T717 1003-1013 NN denotes deficiency
T718 1014-1016 VBZ denotes is
T719 1017-1023 VBN denotes needed
T720 1024-1026 TO denotes to
T721 1027-1035 VB denotes overcome
T722 1036-1039 NNP denotes TMZ
T723 1040-1050 NN denotes resistance
T724 1051-1054 CC denotes and
T725 1055-1061 VB denotes induce
T726 1062-1065 NNP denotes GBM
T727 1066-1070 NN denotes cell
T728 1071-1076 NN denotes death
T729 1076-1077 . denotes .
T2503 1137-1149 NNP denotes Glioblastoma
T2504 1150-1160 JJ denotes multiforme
T2505 1161-1169 VBZ denotes afflicts
T2506 1170-1176 CD denotes 12,500
T2507 1177-1180 JJ denotes new
T2508 1181-1189 NNS denotes patients
T2509 1190-1192 IN denotes in
T2510 1193-1196 DT denotes the
T2511 1197-1201 NNP denotes U.S.
T2512 1202-1210 RB denotes annually
T2513 1211-1212 -LRB- denotes (
T2514 1212-1220 NNP denotes Friedman
T2515 1221-1223 FW denotes et
T2516 1224-1227 FW denotes al.
T2517 1227-1228 , denotes ,
T2518 1229-1233 CD denotes 2000
T2519 1233-1234 : denotes ;
T2520 1235-1240 NNP denotes Stupp
T2521 1241-1243 FW denotes et
T2522 1244-1247 FW denotes al.
T2523 1247-1248 , denotes ,
T2524 1249-1253 CD denotes 2009
T2525 1253-1254 : denotes ;
T2526 1255-1261 NNP denotes Silber
T2527 1262-1264 FW denotes et
T2528 1265-1268 FW denotes al.
T2529 1268-1269 , denotes ,
T2530 1270-1274 CD denotes 2012
T2531 1274-1275 -RRB- denotes )
T2532 1275-1276 . denotes .
T2533 1277-1289 NNP denotes Glioblastoma
T2534 1290-1291 -LRB- denotes (
T2535 1291-1294 NNP denotes GBM
T2536 1294-1295 -RRB- denotes )
T2537 1296-1298 VBZ denotes is
T2538 1299-1305 RB denotes highly
T2539 1306-1312 JJ denotes lethal
T2540 1312-1313 , denotes ,
T2541 1314-1317 CC denotes and
T2542 1318-1321 DT denotes the
T2543 1322-1329 JJ denotes average
T2544 1330-1338 NN denotes survival
T2545 1339-1349 NN denotes expectancy
T2546 1350-1352 VBZ denotes is
T2547 1353-1357 CD denotes 14.6
T2548 1358-1364 NNS denotes months
T2549 1364-1365 , denotes ,
T2550 1366-1369 CC denotes and
T2551 1370-1373 DT denotes the
T2552 1374-1381 JJ denotes overall
T2553 1382-1388 JJ denotes 5-year
T2554 1389-1397 NN denotes survival
T2555 1398-1402 NN denotes rate
T2556 1403-1406 IN denotes for
T2557 1407-1410 NNP denotes GBM
T2558 1411-1413 VBZ denotes is
T2559 1414-1418 RB denotes only
T2560 1419-1422 CD denotes 9.8
T2561 1422-1423 NN denotes %
T2562 1424-1425 -LRB- denotes (
T2563 1425-1433 NNP denotes Friedman
T2564 1434-1436 FW denotes et
T2565 1437-1440 FW denotes al.
T2566 1440-1441 , denotes ,
T2567 1442-1446 CD denotes 2000
T2568 1446-1447 : denotes ;
T2569 1448-1453 NNP denotes Stupp
T2570 1454-1456 FW denotes et
T2571 1457-1460 FW denotes al.
T2572 1460-1461 , denotes ,
T2573 1462-1466 CD denotes 2009
T2574 1466-1467 -RRB- denotes )
T2575 1467-1468 . denotes .
T2576 1469-1473 JJ denotes High
T2577 1474-1480 NNS denotes levels
T2578 1481-1483 IN denotes of
T2579 1484-1494 NN denotes resistance
T2580 1495-1497 TO denotes to
T2581 1498-1505 JJ denotes current
T2582 1506-1517 JJ denotes therapeutic
T2583 1518-1528 NNS denotes modalities
T2584 1529-1532 CC denotes and
T2585 1533-1539 NN denotes cancer
T2586 1540-1547 NN denotes relapse
T2587 1548-1551 VBP denotes are
T2588 1552-1562 RB denotes frequently
T2589 1563-1567 VBN denotes seen
T2590 1568-1570 IN denotes in
T2591 1571-1579 NNS denotes patients
T2592 1580-1581 -LRB- denotes (
T2593 1581-1585 NNP denotes Haar
T2594 1586-1588 FW denotes et
T2595 1589-1592 FW denotes al.
T2596 1592-1593 , denotes ,
T2597 1594-1598 CD denotes 2012
T2598 1598-1599 : denotes ;
T2599 1600-1607 NNP denotes Happold
T2600 1608-1610 FW denotes et
T2601 1611-1614 FW denotes al.
T2602 1614-1615 , denotes ,
T2603 1616-1620 CD denotes 2012
T2604 1620-1621 -RRB- denotes )
T2605 1621-1622 . denotes .
T2606 1623-1626 DT denotes The
T2607 1627-1634 JJ denotes current
T2608 1635-1643 JJ denotes standard
T2609 1644-1651 NN denotes therapy
T2610 1652-1655 IN denotes for
T2611 1656-1659 NNP denotes GBM
T2612 1660-1666 RB denotes mainly
T2613 1667-1675 VBZ denotes includes
T2614 1676-1683 NN denotes maximum
T2615 1684-1693 NN denotes debulking
T2616 1694-1701 NN denotes surgery
T2617 1701-1702 , denotes ,
T2618 1703-1712 NN denotes radiation
T2619 1712-1713 , denotes ,
T2620 1714-1717 CC denotes and
T2621 1718-1727 NN denotes treatment
T2622 1728-1732 IN denotes with
T2623 1733-1736 DT denotes the
T2624 1737-1751 JJ denotes monofunctional
T2625 1752-1762 NN denotes alkylating
T2626 1763-1768 NN denotes agent
T2627 1769-1781 NN denotes temozolomide
T2628 1782-1783 -LRB- denotes (
T2629 1783-1786 NNP denotes TMZ
T2630 1786-1787 -RRB- denotes )
T2631 1788-1789 -LRB- denotes (
T2632 1789-1797 NNP denotes Friedman
T2633 1798-1800 FW denotes et
T2634 1801-1804 FW denotes al.
T2635 1804-1805 , denotes ,
T2636 1806-1810 CD denotes 2000
T2637 1810-1811 : denotes ;
T2638 1812-1821 NNP denotes Nishikawa
T2639 1821-1822 , denotes ,
T2640 1823-1827 CD denotes 2010
T2641 1827-1828 -RRB- denotes )
T2642 1828-1829 . denotes .
T2643 1830-1838 JJ denotes Multiple
T2644 1839-1849 NNS denotes mechanisms
T2645 1850-1853 VBP denotes are
T2646 1854-1862 VBN denotes involved
T2647 1863-1865 IN denotes in
T2648 1866-1869 DT denotes the
T2649 1870-1873 NNP denotes TMZ
T2650 1874-1884 NN denotes resistance
T2651 1884-1885 , denotes ,
T2652 1886-1891 WDT denotes which
T2653 1892-1895 MD denotes may
T2654 1896-1903 VB denotes include
T2655 1904-1910 NN denotes cancer
T2656 1911-1915 NN denotes stem
T2657 1916-1921 NNS denotes cells
T2658 1921-1922 , denotes ,
T2659 1923-1932 NNS denotes microRNAs
T2660 1932-1933 , denotes ,
T2661 1934-1938 NN denotes drug
T2662 1939-1945 NN denotes efflux
T2663 1945-1946 , denotes ,
T2664 1947-1950 NNP denotes DNA
T2665 1951-1957 NN denotes damage
T2666 1958-1964 NN denotes repair
T2667 1964-1965 , denotes ,
T2668 1966-1971 NN denotes tumor
T2669 1972-1977 NNS denotes cells
T2670 1978-1983 IN denotes under
T2671 1984-1991 NN denotes hypoxia
T2672 1991-1992 , denotes ,
T2673 1993-2000 NN denotes histone
T2674 2001-2014 NN denotes deacetylation
T2675 2014-2015 , denotes ,
T2676 2016-2038 JJ denotes epithelial-mesenchymal
T2677 2039-2049 NN denotes transition
T2678 2049-2050 , denotes ,
T2679 2051-2056 CD denotes STAT3
T2680 2057-2063 NN denotes kinase
T2681 2063-2064 , denotes ,
T2682 2065-2068 CC denotes and
T2683 2069-2073 JJ denotes many
T2684 2074-2080 NNS denotes others
T2685 2081-2082 -LRB- denotes (
T2686 2082-2086 NNP denotes Haar
T2687 2087-2089 FW denotes et
T2688 2090-2093 FW denotes al.
T2689 2093-2094 , denotes ,
T2690 2095-2099 CD denotes 2012
T2691 2099-2100 : denotes ;
T2692 2101-2108 NNP denotes Happold
T2693 2109-2111 FW denotes et
T2694 2112-2115 FW denotes al.
T2695 2115-2116 , denotes ,
T2696 2117-2121 CD denotes 2012
T2697 2121-2122 : denotes ;
T2698 2123-2134 NNP denotes Johannessen
T2699 2135-2138 CC denotes and
T2700 2139-2147 NNP denotes Bjerkvig
T2701 2147-2148 , denotes ,
T2702 2149-2153 CD denotes 2012
T2703 2153-2154 : denotes ;
T2704 2155-2162 NNP denotes Kitange
T2705 2163-2165 FW denotes et
T2706 2166-2169 FW denotes al.
T2707 2169-2170 , denotes ,
T2708 2171-2175 CD denotes 2012
T2709 2175-2176 : denotes ;
T2710 2177-2184 NNP denotes Kohsaka
T2711 2185-2187 FW denotes et
T2712 2188-2191 FW denotes al.
T2713 2191-2192 , denotes ,
T2714 2193-2197 CD denotes 2012
T2715 2197-2198 : denotes ;
T2716 2199-2204 NNP denotes Zhang
T2717 2205-2207 FW denotes et
T2718 2208-2211 FW denotes al.
T2719 2211-2212 , denotes ,
T2720 2213-2218 JJ denotes 2012b
T2721 2218-2219 -RRB- denotes )
T2722 2219-2220 . denotes .
T2723 2221-2233 NNP denotes Temozolomide
T2724 2234-2241 VBZ denotes induces
T2725 2242-2252 NN denotes generation
T2726 2253-2255 IN denotes of
T2727 2256-2259 NNP denotes DNA
T2728 2260-2267 NNS denotes lesions
T2729 2267-2268 , denotes ,
T2730 2269-2278 VBG denotes including
T2731 2279-2295 NNP denotes O6-methylguanine
T2732 2295-2296 , denotes ,
T2733 2297-2313 NNP denotes N3-methyladenine
T2734 2313-2314 , denotes ,
T2735 2315-2318 CC denotes and
T2736 2319-2335 NNP denotes N7-methylguanine
T2737 2336-2337 -LRB- denotes (
T2738 2337-2345 NNP denotes Goellner
T2739 2346-2348 FW denotes et
T2740 2349-2352 FW denotes al.
T2741 2352-2353 , denotes ,
T2742 2354-2358 CD denotes 2011
T2743 2358-2359 : denotes ;
T2744 2360-2365 NNP denotes Zhang
T2745 2366-2368 FW denotes et
T2746 2369-2372 FW denotes al.
T2747 2372-2373 , denotes ,
T2748 2374-2379 JJ denotes 2012b
T2749 2379-2380 -RRB- denotes )
T2750 2380-2381 . denotes .
T2751 2382-2385 DT denotes The
T2752 2386-2402 JJ denotes O6-methylguanine
T2753 2403-2409 NN denotes lesion
T2754 2410-2412 VBZ denotes is
T2755 2413-2418 VBN denotes known
T2756 2419-2421 TO denotes to
T2757 2422-2429 VB denotes trigger
T2758 2430-2439 NN denotes autophagy
T2759 2439-2440 , denotes ,
T2760 2441-2447 RB denotes rather
T2761 2448-2452 IN denotes than
T2762 2453-2462 NN denotes apoptosis
T2763 2462-2463 , denotes ,
T2764 2464-2466 TO denotes to
T2765 2467-2472 VB denotes cause
T2766 2473-2477 NN denotes cell
T2767 2478-2483 NN denotes death
T2768 2484-2485 -LRB- denotes (
T2769 2485-2492 NNP denotes Kanzawa
T2770 2493-2495 FW denotes et
T2771 2496-2499 FW denotes al.
T2772 2499-2500 , denotes ,
T2773 2501-2505 CD denotes 2003
T2774 2505-2506 -RRB- denotes )
T2775 2506-2507 . denotes .
T2776 2508-2512 RB denotes Also
T2777 2512-2513 , denotes ,
T2778 2514-2524 NN denotes inhibition
T2779 2525-2527 IN denotes of
T2780 2528-2541 JJ denotes antiapoptotic
T2781 2542-2547 NN denotes Bcl-2
T2782 2548-2550 IN denotes by
T2783 2551-2552 DT denotes a
T2784 2553-2562 NN denotes pan-Bcl-2
T2785 2563-2572 NN denotes inhibitor
T2786 2573-2574 -LRB- denotes (
T2787 2574-2575 FW denotes −
T2788 2575-2576 -RRB- denotes )
T2789 2576-2577 : denotes -
T2790 2577-2585 NN denotes gossypol
T2791 2586-2591 VBZ denotes leads
T2792 2592-2594 TO denotes to
T2793 2595-2605 JJ denotes autophagic
T2794 2606-2611 NN denotes death
T2795 2612-2614 IN denotes in
T2796 2615-2622 NNS denotes gliomas
T2797 2623-2626 CC denotes and
T2798 2627-2635 VBZ denotes enhances
T2799 2636-2639 DT denotes the
T2800 2640-2646 NN denotes action
T2801 2647-2649 IN denotes of
T2802 2650-2653 NNP denotes TMZ
T2803 2654-2655 -LRB- denotes (
T2804 2655-2659 NNP denotes Voss
T2805 2660-2662 FW denotes et
T2806 2663-2666 FW denotes al.
T2807 2666-2667 , denotes ,
T2808 2668-2672 CD denotes 2010
T2809 2672-2673 -RRB- denotes )
T2810 2673-2674 . denotes .
T2811 2675-2682 RB denotes However
T2812 2682-2683 , denotes ,
T2813 2684-2685 DT denotes a
T2814 2686-2692 JJ denotes recent
T2815 2693-2698 NN denotes study
T2816 2699-2711 VBD denotes demonstrated
T2817 2712-2716 IN denotes that
T2818 2717-2728 JJ denotes TMZ-induced
T2819 2729-2738 NN denotes autophagy
T2820 2739-2741 VBZ denotes is
T2821 2742-2754 JJ denotes pro-survival
T2822 2754-2755 , denotes ,
T2823 2756-2759 CC denotes and
T2824 2760-2763 MD denotes may
T2825 2764-2769 VB denotes block
T2826 2770-2773 DT denotes the
T2827 2774-2782 JJ denotes eventual
T2828 2783-2792 NN denotes apoptosis
T2829 2793-2795 IN denotes in
T2830 2796-2799 NNP denotes GBM
T2831 2800-2805 NNS denotes cells
T2832 2806-2807 -LRB- denotes (
T2833 2807-2815 NNP denotes Knizhnik
T2834 2816-2818 FW denotes et
T2835 2819-2822 FW denotes al.
T2836 2822-2823 , denotes ,
T2837 2824-2828 CD denotes 2013
T2838 2828-2829 -RRB- denotes )
T2839 2829-2830 . denotes .
T2840 2831-2835 RB denotes Also
T2841 2835-2836 , denotes ,
T2842 2837-2842 NNP denotes MAPO2
T2843 2843-2844 -LRB- denotes (
T2844 2844-2852 NNP denotes C1orf201
T2845 2852-2853 -RRB- denotes )
T2846 2854-2858 NN denotes gene
T2847 2859-2871 VBZ denotes participates
T2848 2872-2874 IN denotes in
T2849 2875-2878 DT denotes the
T2850 2879-2895 JJ denotes O6-methylguanine
T2851 2896-2910 JJ denotes lesion-induced
T2852 2911-2920 NN denotes apoptosis
T2853 2921-2922 -LRB- denotes (
T2854 2922-2930 NNP denotes Fujikane
T2855 2931-2933 FW denotes et
T2856 2934-2937 FW denotes al.
T2857 2937-2938 , denotes ,
T2858 2939-2943 CD denotes 2012
T2859 2943-2944 -RRB- denotes )
T2860 2944-2945 . denotes .
T2861 2946-2951 CD denotes MAPO2
T2862 2952-2956 NN denotes gene
T2863 2957-2964 VBZ denotes encodes
T2864 2965-2966 DT denotes a
T2865 2967-2972 NN denotes novel
T2866 2973-2979 NN denotes 37-kDa
T2867 2980-2987 NN denotes protein
T2868 2987-2988 . denotes .
T2869 2989-2991 PRP denotes It
T2870 2992-2994 VBZ denotes is
T2871 2995-2998 RB denotes not
T2872 2999-3009 VBN denotes determined
T2873 3010-3017 IN denotes whether
T2874 3018-3022 DT denotes this
T2875 3023-3027 NN denotes gene
T2876 3028-3030 VBZ denotes is
T2877 3031-3039 VBN denotes involved
T2878 3040-3042 IN denotes in
T2879 3043-3052 NN denotes autophagy
T2880 3052-3053 . denotes .
T2881 3054-3057 DT denotes The
T2882 3058-3074 JJ denotes O6-methylguanine
T2883 3075-3081 NN denotes lesion
T2884 3082-3084 VBZ denotes is
T2885 3085-3086 DT denotes a
T2886 3087-3096 NN denotes substrate
T2887 3097-3100 IN denotes for
T2888 3101-3107 JJ denotes direct
T2889 3108-3114 NN denotes repair
T2890 3115-3117 IN denotes by
T2891 3118-3138 NNP denotes O6-methylguanine-DNA
T2892 3139-3156 NN denotes methyltransferase
T2893 3157-3158 -LRB- denotes (
T2894 3158-3162 NNP denotes MGMT
T2895 3162-3163 -RRB- denotes )
T2896 3164-3165 -LRB- denotes (
T2897 3165-3172 NNP denotes Pollack
T2898 3173-3175 FW denotes et
T2899 3176-3179 FW denotes al.
T2900 3179-3180 , denotes ,
T2901 3181-3185 CD denotes 2006
T2902 3185-3186 : denotes ;
T2903 3187-3191 NNP denotes Hegi
T2904 3192-3194 FW denotes et
T2905 3195-3198 FW denotes al.
T2906 3198-3199 , denotes ,
T2907 3200-3204 CD denotes 2008
T2908 3204-3205 : denotes ;
T2909 3206-3215 NNP denotes Fukushima
T2910 3216-3218 FW denotes et
T2911 3219-3222 FW denotes al.
T2912 3222-3223 , denotes ,
T2913 3224-3228 CD denotes 2009
T2914 3228-3229 : denotes ;
T2915 3230-3235 NNP denotes Zhang
T2916 3236-3238 FW denotes et
T2917 3239-3242 FW denotes al.
T2918 3242-3243 , denotes ,
T2919 3244-3249 JJ denotes 2012b
T2920 3249-3250 -RRB- denotes )
T2921 3250-3251 . denotes .
T2922 3252-3259 IN denotes Without
T2923 3260-3264 NNP denotes MGMT
T2924 3265-3271 NN denotes repair
T2925 3271-3272 , denotes ,
T2926 3273-3289 JJ denotes O6-methylguanine
T2927 3290-3299 NNS denotes initiates
T2928 3300-3310 NN denotes activation
T2929 3311-3313 IN denotes of
T2930 3314-3322 NN denotes mismatch
T2931 3323-3339 NN denotes repair-deficient
T2932 3340-3341 -LRB- denotes (
T2933 3341-3344 NNP denotes MMR
T2934 3344-3345 -RRB- denotes )
T2935 3346-3354 NNS denotes proteins
T2936 3355-3357 CC denotes or
T2937 3358-3370 JJ denotes Rad3-related
T2938 3371-3378 NN denotes protein
T2939 3379-3385 NN denotes kinase
T2940 3386-3390 WDT denotes that
T2941 3391-3401 RB denotes ultimately
T2942 3402-3407 VBZ denotes leads
T2943 3408-3410 TO denotes to
T2944 3411-3420 JJ denotes apoptotic
T2945 3421-3425 NN denotes cell
T2946 3426-3431 NN denotes death
T2947 3432-3433 -LRB- denotes (
T2948 3433-3441 NNP denotes Caporali
T2949 3442-3444 FW denotes et
T2950 3445-3448 FW denotes al.
T2951 3448-3449 , denotes ,
T2952 3450-3454 CD denotes 2004
T2953 3454-3455 : denotes ;
T2954 3456-3460 NNP denotes Wang
T2955 3461-3464 CC denotes and
T2956 3465-3473 NNP denotes Edelmann
T2957 3473-3474 , denotes ,
T2958 3475-3479 CD denotes 2006
T2959 3479-3480 : denotes ;
T2960 3481-3485 NNP denotes Roos
T2961 3486-3488 FW denotes et
T2962 3489-3492 FW denotes al.
T2963 3492-3493 , denotes ,
T2964 3494-3498 CD denotes 2007
T2965 3498-3499 -RRB- denotes )
T2966 3499-3500 . denotes .
T2967 3501-3505 NNP denotes High
T2968 3506-3516 NN denotes expression
T2969 3517-3519 IN denotes of
T2970 3520-3524 NNP denotes MGMT
T2971 3525-3527 CC denotes or
T2972 3528-3532 NN denotes loss
T2973 3533-3535 IN denotes of
T2974 3536-3539 NNP denotes MMR
T2975 3540-3551 VBZ denotes contributes
T2976 3552-3565 RB denotes significantly
T2977 3566-3568 TO denotes to
T2978 3569-3572 NNP denotes TMZ
T2979 3573-3583 NN denotes resistance
T2980 3584-3586 IN denotes in
T2981 3587-3591 JJ denotes many
T2982 3592-3600 JJ denotes clinical
T2983 3601-3606 NNS denotes cases
T2984 3607-3608 -LRB- denotes (
T2985 3608-3615 NNP denotes Pollack
T2986 3616-3618 FW denotes et
T2987 3619-3622 FW denotes al.
T2988 3622-3623 , denotes ,
T2989 3624-3628 CD denotes 2006
T2990 3628-3629 : denotes ;
T2991 3630-3634 NNP denotes Hegi
T2992 3635-3637 FW denotes et
T2993 3638-3641 FW denotes al.
T2994 3641-3642 , denotes ,
T2995 3643-3647 CD denotes 2008
T2996 3647-3648 : denotes ;
T2997 3649-3657 NNP denotes Sarkaria
T2998 3658-3660 FW denotes et
T2999 3661-3664 FW denotes al.
T3000 3664-3665 , denotes ,
T3001 3666-3670 CD denotes 2008
T3002 3670-3671 -RRB- denotes )
T3003 3671-3672 . denotes .
T3004 3673-3676 DT denotes The
T3005 3677-3687 NN denotes initiation
T3006 3688-3690 IN denotes of
T3007 3691-3700 JJ denotes apoptotic
T3008 3701-3710 VBG denotes signaling
T3009 3711-3716 VBZ denotes fails
T3010 3717-3719 IN denotes in
T3011 3720-3723 DT denotes the
T3012 3724-3731 NN denotes absence
T3013 3732-3734 IN denotes of
T3014 3735-3738 DT denotes the
T3015 3739-3742 NNP denotes MMR
T3016 3743-3749 NN denotes system
T3017 3749-3750 . denotes .
T3018 3751-3762 NN denotes Sensitivity
T3019 3763-3765 TO denotes to
T3020 3766-3769 NNP denotes TMZ
T3021 3770-3772 VBZ denotes is
T3022 3773-3786 RB denotes significantly
T3023 3787-3797 VBN denotes associated
T3024 3798-3802 IN denotes with
T3025 3803-3806 DT denotes the
T3026 3807-3818 NN denotes methylation
T3027 3819-3825 NN denotes status
T3028 3826-3828 IN denotes of
T3029 3829-3833 NNP denotes MGMT
T3030 3834-3838 NN denotes gene
T3031 3839-3847 NN denotes promoter
T3032 3848-3850 IN denotes in
T3033 3851-3856 NNS denotes cells
T3034 3857-3866 VBN denotes committed
T3035 3867-3869 TO denotes to
T3036 3870-3885 NN denotes differentiation
T3037 3886-3887 -LRB- denotes (
T3038 3887-3895 NNP denotes Villalva
T3039 3896-3898 FW denotes et
T3040 3899-3902 FW denotes al.
T3041 3902-3903 , denotes ,
T3042 3904-3908 CD denotes 2012
T3043 3908-3909 -RRB- denotes )
T3044 3909-3910 . denotes .
T3045 3911-3913 DT denotes An
T3046 3914-3922 NN denotes increase
T3047 3923-3925 IN denotes in
T3048 3926-3930 NNP denotes MGMT
T3049 3931-3935 NN denotes gene
T3050 3936-3944 NN denotes promoter
T3051 3945-3956 NN denotes methylation
T3052 3956-3957 , denotes ,
T3053 3958-3963 WDT denotes which
T3054 3964-3970 VBZ denotes blocks
T3055 3971-3975 NNP denotes MGMT
T3056 3976-3983 NN denotes protein
T3057 3984-3994 NN denotes expression
T3058 3994-3995 , denotes ,
T3059 3996-4004 VBZ denotes prolongs
T3060 4005-4011 NN denotes cancer
T3061 4012-4019 NN denotes patient
T3062 4020-4028 NN denotes survival
T3063 4028-4029 . denotes .
T3064 4030-4042 RB denotes Intriguingly
T3065 4042-4043 , denotes ,
T3066 4044-4057 VBD denotes overexpressed
T3067 4058-4069 NN denotes microRNA-21
T3068 4070-4077 VBZ denotes reduces
T3069 4078-4085 NNP denotes Bax/Bcl
T3070 4085-4087 CD denotes -2
T3071 4088-4093 NN denotes ratio
T3072 4094-4097 CC denotes and
T3073 4098-4107 JJ denotes caspase-3
T3074 4108-4116 NN denotes activity
T3075 4116-4117 , denotes ,
T3076 4118-4125 RB denotes thereby
T3077 4126-4134 VBG denotes blocking
T3078 4135-4146 JJ denotes TMZ-induced
T3079 4147-4156 NN denotes apoptosis
T3080 4157-4158 -LRB- denotes (
T3081 4158-4161 NNP denotes Shi
T3082 4162-4164 FW denotes et
T3083 4165-4168 FW denotes al.
T3084 4168-4169 , denotes ,
T3085 4170-4174 CD denotes 2010
T3086 4174-4175 -RRB- denotes )
T3087 4175-4176 . denotes .
T3088 4177-4188 NN denotes MicroRNA-21
T3089 4189-4191 VBZ denotes is
T3090 4192-4202 VBN denotes considered
T3091 4203-4205 IN denotes as
T3092 4206-4207 DT denotes a
T3093 4208-4220 JJ denotes pro-survival
T3094 4221-4227 NN denotes factor
T3095 4228-4231 IN denotes for
T3096 4232-4238 NN denotes cancer
T3097 4239-4244 NNS denotes cells
T3098 4245-4246 -LRB- denotes (
T3099 4246-4248 NNP denotes Li
T3100 4249-4251 FW denotes et
T3101 4252-4255 FW denotes al.
T3102 4255-4256 , denotes ,
T3103 4257-4261 CD denotes 2012
T3104 4261-4262 -RRB- denotes )
T3105 4262-4263 . denotes .
T3106 4264-4273 NNS denotes Integrins
T3107 4274-4278 VBP denotes play
T3108 4279-4280 DT denotes a
T3109 4281-4285 NN denotes role
T3110 4286-4288 IN denotes in
T3111 4289-4292 DT denotes the
T3112 4293-4303 NN denotes resistance
T3113 4304-4306 IN denotes of
T3114 4307-4315 JJ denotes advanced
T3115 4316-4323 NNS denotes cancers
T3116 4324-4326 TO denotes to
T3117 4327-4339 JJ denotes radiotherapy
T3118 4340-4343 CC denotes and
T3119 4344-4356 JJ denotes chemotherapy
T3120 4356-4357 . denotes .
T3121 4358-4362 JJ denotes α5β1
T3122 4363-4371 NN denotes integrin
T3123 4372-4382 RB denotes negatively
T3124 4383-4392 VBZ denotes regulates
T3125 4393-4396 NN denotes p53
T3126 4397-4406 VBG denotes signaling
T3127 4406-4407 , denotes ,
T3128 4408-4411 CC denotes and
T3129 4412-4415 DT denotes the
T3130 4416-4421 NN denotes event
T3131 4422-4429 VBZ denotes induces
T3132 4430-4436 NN denotes glioma
T3133 4437-4441 NN denotes cell
T3134 4442-4452 NN denotes resistance
T3135 4453-4455 TO denotes to
T3136 4456-4459 NNP denotes TMZ
T3137 4460-4461 -LRB- denotes (
T3138 4461-4471 NNP denotes Janouskova
T3139 4472-4474 FW denotes et
T3140 4475-4478 FW denotes al.
T3141 4478-4479 , denotes ,
T3142 4480-4484 CD denotes 2012
T3143 4484-4485 -RRB- denotes )
T3144 4485-4486 . denotes .
T3145 4487-4491 JJ denotes α5β1
T3146 4492-4500 NN denotes integrin
T3147 4501-4503 VBZ denotes is
T3148 4504-4514 VBN denotes considered
T3149 4515-4517 IN denotes as
T3150 4518-4519 DT denotes a
T3151 4520-4531 JJ denotes therapeutic
T3152 4532-4538 NN denotes target
T3153 4539-4542 IN denotes for
T3154 4543-4553 JJ denotes high-grade
T3155 4554-4559 NN denotes brain
T3156 4560-4566 NNS denotes tumors
T3157 4566-4567 . denotes .
T3158 4568-4571 DT denotes The
T3159 4572-4576 NN denotes base
T3160 4577-4585 NN denotes excision
T3161 4586-4592 NN denotes repair
T3162 4593-4599 NN denotes enzyme
T3163 4600-4629 JJ denotes alkylpurine-DNA-N-glycosylase
T3164 4630-4631 -LRB- denotes (
T3165 4631-4635 NNP denotes APNG
T3166 4635-4636 -RRB- denotes )
T3167 4636-4637 , denotes ,
T3168 4638-4643 WDT denotes which
T3169 4644-4651 NNS denotes repairs
T3170 4652-4655 DT denotes the
T3171 4656-4665 JJ denotes cytotoxic
T3172 4666-4673 NNS denotes lesions
T3173 4674-4690 JJ denotes N3-methyladenine
T3174 4691-4694 CC denotes and
T3175 4695-4711 JJ denotes N7-methylguanine
T3176 4711-4712 , denotes ,
T3177 4713-4717 RB denotes also
T3178 4718-4730 VBZ denotes participates
T3179 4731-4733 IN denotes in
T3180 4734-4737 DT denotes the
T3181 4738-4741 NNP denotes TMZ
T3182 4742-4752 NN denotes resistance
T3183 4753-4754 -LRB- denotes (
T3184 4754-4763 NNP denotes Agnihotri
T3185 4764-4766 FW denotes et
T3186 4767-4770 FW denotes al.
T3187 4770-4771 , denotes ,
T3188 4772-4776 CD denotes 2012
T3189 4776-4777 -RRB- denotes )
T3190 4777-4778 . denotes .
T3191 4779-4791 NNP denotes Upregulation
T3192 4792-4794 IN denotes of
T3193 4795-4808 JJ denotes mitochondrial
T3194 4809-4820 JJ denotes respiratory
T3195 4821-4826 NN denotes chain
T3196 4827-4835 NN denotes coupling
T3197 4836-4838 TO denotes to
T3198 4839-4847 VB denotes suppress
T3199 4848-4851 DT denotes the
T3200 4852-4862 NN denotes production
T3201 4863-4865 IN denotes of
T3202 4866-4874 JJ denotes reactive
T3203 4875-4881 NN denotes oxygen
T3204 4882-4889 NNS denotes species
T3205 4890-4891 -LRB- denotes (
T3206 4891-4894 NNP denotes ROS
T3207 4894-4895 -RRB- denotes )
T3208 4896-4905 VBN denotes regulated
T3209 4906-4908 IN denotes by
T3210 4909-4919 NN denotes cytochrome
T3211 4920-4921 NN denotes c
T3212 4922-4929 NN denotes oxidase
T3213 4930-4941 VBZ denotes contributes
T3214 4942-4944 IN denotes in
T3215 4945-4949 NN denotes part
T3216 4950-4952 TO denotes to
T3217 4953-4956 NNP denotes TMZ
T3218 4957-4967 NN denotes resistance
T3219 4968-4970 IN denotes in
T3220 4971-4978 NNS denotes gliomas
T3221 4979-4980 -LRB- denotes (
T3222 4980-4985 NNP denotes Oliva
T3223 4986-4988 FW denotes et
T3224 4989-4992 FW denotes al.
T3225 4992-4993 , denotes ,
T3226 4994-4998 CD denotes 2011
T3227 4998-4999 -RRB- denotes )
T3228 4999-5000 . denotes .
T3229 5001-5009 NN denotes Reversal
T3230 5010-5012 IN denotes of
T3231 5013-5016 NNP denotes TMZ
T3232 5017-5027 NN denotes resistance
T3233 5028-5031 MD denotes may
T3234 5032-5034 VB denotes be
T3235 5035-5043 VBN denotes achieved
T3236 5044-5046 IN denotes by
T3237 5047-5051 NNP denotes MGMT
T3238 5052-5068 NNS denotes pseudosubstrates
T3239 5068-5069 , denotes ,
T3240 5070-5086 NN denotes O6-benzylguanine
T3241 5087-5090 CC denotes and
T3242 5091-5102 NN denotes lomeguatrib
T3243 5103-5105 TO denotes to
T3244 5106-5115 VB denotes sensitize
T3245 5116-5122 NNS denotes tumors
T3246 5123-5125 TO denotes to
T3247 5126-5129 NNP denotes TMZ
T3248 5130-5131 -LRB- denotes (
T3249 5131-5136 NNP denotes Zhang
T3250 5137-5139 FW denotes et
T3251 5140-5143 FW denotes al.
T3252 5143-5144 , denotes ,
T3253 5145-5150 JJ denotes 2012b
T3254 5150-5151 -RRB- denotes )
T3255 5151-5152 . denotes .
T3256 5153-5173 NN denotes Methoxyamine-blocker
T3257 5174-5176 IN denotes of
T3258 5177-5181 NN denotes base
T3259 5182-5190 NN denotes excision
T3260 5191-5197 NN denotes repair
T3261 5198-5209 VBZ denotes contributes
T3262 5210-5223 RB denotes significantly
T3263 5224-5226 TO denotes to
T3264 5227-5230 NNP denotes TMZ
T3265 5231-5243 NN denotes cytotoxicity
T3266 5244-5256 RB denotes particularly
T3267 5257-5261 WRB denotes when
T3268 5262-5278 JJ denotes O6-methylguanine
T3269 5279-5286 NNS denotes adducts
T3270 5287-5290 VBP denotes are
T3271 5291-5299 VBN denotes repaired
T3272 5300-5302 CC denotes or
T3273 5303-5312 VBN denotes tolerated
T3274 5313-5314 -LRB- denotes (
T3275 5314-5322 NNP denotes Goellner
T3276 5323-5325 FW denotes et
T3277 5326-5329 FW denotes al.
T3278 5329-5330 , denotes ,
T3279 5331-5335 CD denotes 2011
T3280 5335-5336 : denotes ;
T3281 5337-5342 NNP denotes Zhang
T3282 5343-5345 FW denotes et
T3283 5346-5349 FW denotes al.
T3284 5349-5350 , denotes ,
T3285 5351-5356 JJ denotes 2012b
T3286 5356-5357 -RRB- denotes )
T3287 5357-5358 . denotes .
T3288 5359-5363 JJ denotes Dual
T3289 5364-5373 VBG denotes targeting
T3290 5374-5376 IN denotes of
T3291 5377-5381 NN denotes base
T3292 5382-5390 NN denotes excision
T3293 5391-5397 NN denotes repair
T3294 5398-5401 CC denotes and
T3295 5402-5405 NNP denotes NAD
T3296 5405-5406 -LRB- denotes (
T3297 5406-5407 VBN denotes +
T3298 5407-5408 -RRB- denotes )
T3299 5409-5421 NN denotes biosynthesis
T3300 5422-5425 MD denotes may
T3301 5426-5433 VB denotes reverse
T3302 5434-5437 NNP denotes TMZ
T3303 5438-5448 NN denotes resistance
T3304 5449-5451 IN denotes in
T3305 5452-5460 NNS denotes patients
T3306 5461-5465 IN denotes with
T3307 5466-5475 JJ denotes resistant
T3308 5476-5479 CC denotes and
T3309 5480-5489 JJ denotes recurrent
T3310 5490-5493 NNP denotes GBM
T3311 5494-5495 -LRB- denotes (
T3312 5495-5503 NNP denotes Goellner
T3313 5504-5506 FW denotes et
T3314 5507-5510 FW denotes al.
T3315 5510-5511 , denotes ,
T3316 5512-5516 CD denotes 2011
T3317 5516-5517 -RRB- denotes )
T3318 5517-5518 . denotes .
T3319 5519-5531 NNP denotes Interferon-β
T3320 5532-5533 -LRB- denotes (
T3321 5533-5538 NNP denotes IFN-β
T3322 5538-5539 -RRB- denotes )
T3323 5539-5540 , denotes ,
T3324 5541-5554 NN denotes levetiracetam
T3325 5555-5556 -LRB- denotes (
T3326 5556-5559 NNP denotes LEV
T3327 5559-5560 -RRB- denotes )
T3328 5560-5561 , denotes ,
T3329 5562-5573 NN denotes resveratrol
T3330 5573-5574 , denotes ,
T3331 5575-5578 CC denotes and
T3332 5579-5587 JJ denotes valproic
T3333 5588-5592 NN denotes acid
T3334 5593-5594 -LRB- denotes (
T3335 5594-5597 NNP denotes VAP
T3336 5597-5598 -RRB- denotes )
T3337 5599-5607 VB denotes increase
T3338 5608-5611 DT denotes the
T3339 5612-5623 NN denotes sensitivity
T3340 5624-5626 IN denotes of
T3341 5627-5630 NNP denotes TMZ
T3342 5631-5638 IN denotes through
T3343 5639-5653 NNP denotes MGMT-dependent
T3344 5654-5656 CC denotes or
T3345 5657-5658 : denotes -
T3346 5658-5669 JJ denotes independent
T3347 5670-5680 NNS denotes mechanisms
T3348 5681-5682 -LRB- denotes (
T3349 5682-5688 NNP denotes Nakada
T3350 5689-5691 FW denotes et
T3351 5692-5695 FW denotes al.
T3352 5695-5696 , denotes ,
T3353 5697-5701 CD denotes 2012
T3354 5701-5702 -RRB- denotes )
T3355 5702-5703 . denotes .
T3356 5704-5715 NNP denotes Resveratrol
T3357 5715-5716 , denotes ,
T3358 5717-5718 DT denotes a
T3359 5719-5726 JJ denotes natural
T3360 5727-5737 NN denotes polyphenol
T3361 5737-5738 , denotes ,
T3362 5739-5747 VBZ denotes reverses
T3363 5748-5751 NNP denotes TMZ
T3364 5752-5762 NN denotes resistance
T3365 5763-5766 IN denotes via
T3366 5767-5769 DT denotes an
T3367 5770-5785 JJ denotes NF-κB-dependent
T3368 5786-5795 NN denotes mechanism
T3369 5796-5797 -LRB- denotes (
T3370 5797-5802 NNP denotes Huang
T3371 5803-5805 FW denotes et
T3372 5806-5809 FW denotes al.
T3373 5809-5810 , denotes ,
T3374 5811-5815 CD denotes 2012
T3375 5815-5816 -RRB- denotes )
T3376 5816-5817 . denotes .
T3377 5818-5823 CD denotes STAT3
T3378 5824-5833 NN denotes inhibitor
T3379 5834-5836 CC denotes or
T3380 5837-5842 CD denotes STAT3
T3381 5843-5852 JJ denotes knockdown
T3382 5853-5864 NNS denotes potentiates
T3383 5865-5868 NNP denotes TMZ
T3384 5869-5877 NN denotes efficacy
T3385 5878-5880 IN denotes in
T3386 5881-5890 JJ denotes resistant
T3387 5891-5894 NNP denotes GBM
T3388 5895-5899 NN denotes cell
T3389 5900-5905 NNS denotes lines
T3390 5906-5907 -LRB- denotes (
T3391 5907-5914 NNP denotes Kohsaka
T3392 5915-5917 FW denotes et
T3393 5918-5921 FW denotes al.
T3394 5921-5922 , denotes ,
T3395 5923-5927 CD denotes 2012
T3396 5927-5928 -RRB- denotes )
T3397 5928-5929 . denotes .
T3398 5930-5942 NNP denotes Intratumoral
T3399 5943-5950 NN denotes hypoxia
T3400 5951-5953 VBZ denotes is
T3401 5954-5960 JJ denotes common
T3402 5961-5963 IN denotes in
T3403 5964-5968 NNS denotes GBMs
T3404 5969-5972 CC denotes and
T3405 5973-5976 MD denotes may
T3406 5977-5979 VB denotes be
T3407 5980-5990 VBN denotes associated
T3408 5991-5995 IN denotes with
T3409 5996-5999 DT denotes the
T3410 6000-6011 NN denotes development
T3411 6012-6014 IN denotes of
T3412 6015-6018 NNP denotes TMZ
T3413 6019-6029 NN denotes resistance
T3414 6029-6030 . denotes .
T3415 6031-6038 VBN denotes Induced
T3416 6039-6048 NN denotes hyperoxia
T3417 6049-6052 MD denotes can
T3418 6053-6055 VB denotes be
T3419 6056-6064 VBN denotes utilized
T3420 6065-6067 TO denotes to
T3421 6068-6075 VB denotes reverse
T3422 6076-6079 NNP denotes TMZ
T3423 6080-6090 NN denotes resistance
T3424 6091-6093 IN denotes in
T3425 6094-6098 NNS denotes GBMs
T3426 6099-6100 -LRB- denotes (
T3427 6100-6103 NNP denotes Sun
T3428 6104-6106 FW denotes et
T3429 6107-6110 FW denotes al.
T3430 6110-6111 , denotes ,
T3431 6112-6116 CD denotes 2012
T3432 6116-6117 -RRB- denotes )
T3433 6117-6118 . denotes .
T3434 6119-6125 NNP denotes Cancer
T3435 6126-6130 NN denotes stem
T3436 6131-6136 NNS denotes cells
T3437 6137-6140 VBP denotes are
T3438 6141-6149 RB denotes probably
T3439 6150-6153 DT denotes the
T3440 6154-6157 NN denotes key
T3441 6158-6160 TO denotes to
T3442 6161-6168 NN denotes failure
T3443 6169-6171 IN denotes in
T3444 6172-6175 NNP denotes TMZ
T3445 6176-6185 NN denotes treatment
T3446 6185-6186 . denotes .
T3447 6187-6190 DT denotes The
T3448 6191-6198 NN denotes concept
T3449 6199-6201 IN denotes of
T3450 6202-6208 NN denotes cancer
T3451 6209-6213 NN denotes stem
T3452 6214-6218 NN denotes cell
T3453 6219-6227 NN denotes survival
T3454 6228-6232 IN denotes from
T3455 6233-6242 NN denotes treatment
T3456 6243-6247 IN denotes with
T3457 6248-6251 NNP denotes TMZ
T3458 6252-6255 CC denotes and
T3459 6256-6261 JJ denotes other
T3460 6262-6278 JJ denotes chemotherapeutic
T3461 6279-6284 NNS denotes drugs
T3462 6285-6288 VBZ denotes has
T3463 6289-6293 VBN denotes been
T3464 6294-6298 RBR denotes more
T3465 6299-6310 JJ denotes complicated
T3466 6311-6315 IN denotes than
T3467 6316-6326 RB denotes previously
T3468 6327-6334 VBN denotes thought
T3469 6335-6336 -LRB- denotes (
T3470 6336-6341 NNP denotes Beier
T3471 6342-6344 FW denotes et
T3472 6345-6348 FW denotes al.
T3473 6348-6349 , denotes ,
T3474 6350-6354 CD denotes 2011
T3475 6354-6355 : denotes ;
T3476 6356-6360 NNP denotes Chen
T3477 6361-6363 FW denotes et
T3478 6364-6367 FW denotes al.
T3479 6367-6368 , denotes ,
T3480 6369-6373 CD denotes 2012
T3481 6373-6374 -RRB- denotes )
T3482 6374-6375 . denotes .
T3483 6376-6390 JJ denotes CD133-positive
T3484 6391-6397 NN denotes cancer
T3485 6398-6402 NN denotes stem
T3486 6403-6408 NNS denotes cells
T3487 6409-6412 VBP denotes are
T3488 6413-6422 VBN denotes expressed
T3489 6423-6425 IN denotes in
T3490 6426-6430 DT denotes both
T3491 6431-6437 JJ denotes normal
T3492 6438-6442 NN denotes stem
T3493 6443-6448 NNS denotes cells
T3494 6449-6452 CC denotes and
T3495 6453-6459 NN denotes cancer
T3496 6460-6464 NN denotes stem
T3497 6465-6470 NNS denotes cells
T3498 6471-6472 -LRB- denotes (
T3499 6472-6479 NNP denotes Donovan
T3500 6480-6483 CC denotes and
T3501 6484-6494 NNP denotes Pilkington
T3502 6494-6495 , denotes ,
T3503 6496-6500 CD denotes 2012
T3504 6500-6501 -RRB- denotes )
T3505 6501-6502 . denotes .
T3506 6503-6510 RB denotes However
T3507 6510-6511 , denotes ,
T3508 6512-6515 DT denotes the
T3509 6516-6520 NN denotes role
T3510 6521-6523 IN denotes of
T3511 6524-6529 NNP denotes CD133
T3512 6530-6532 IN denotes as
T3513 6533-6534 DT denotes a
T3514 6535-6541 NN denotes marker
T3515 6542-6545 IN denotes for
T3516 6546-6552 NN denotes glioma
T3517 6553-6559 NN denotes cancer
T3518 6560-6564 NN denotes stem
T3519 6565-6570 NNS denotes cells
T3520 6571-6579 JJ denotes relative
T3521 6580-6582 TO denotes to
T3522 6583-6586 PRP$ denotes its
T3523 6587-6597 JJ denotes biological
T3524 6598-6606 NN denotes function
T3525 6607-6610 VBZ denotes has
T3526 6611-6614 RB denotes yet
T3527 6615-6617 TO denotes to
T3528 6618-6620 VB denotes be
T3529 6621-6632 VBN denotes established
T3530 6632-6633 . denotes .
T5771 6676-6684 RB denotes Recently
T5772 6684-6685 , denotes ,
T5773 6686-6691 NN denotes tumor
T5774 6692-6703 NNS denotes suppressors
T5775 6704-6707 NN denotes p53
T5776 6708-6711 CC denotes and
T5777 6712-6716 NNP denotes WWOX
T5778 6717-6721 VBD denotes were
T5779 6722-6727 VBN denotes shown
T5780 6728-6730 TO denotes to
T5781 6731-6739 VB denotes regulate
T5782 6740-6743 DT denotes the
T5783 6744-6753 NN denotes apoptosis
T5784 6754-6756 IN denotes of
T5785 6757-6769 NN denotes glioblastoma
T5786 6770-6775 NNS denotes cells
T5787 6776-6777 -LRB- denotes (
T5788 6777-6783 NNP denotes Chiang
T5789 6784-6786 FW denotes et
T5790 6787-6790 FW denotes al.
T5791 6790-6791 , denotes ,
T5792 6792-6796 CD denotes 2012
T5793 6796-6797 -RRB- denotes )
T5794 6797-6798 . denotes .
T5795 6799-6801 NNP denotes WW
T5796 6802-6819 JJ denotes domain-containing
T5797 6820-6834 NN denotes oxidoreductase
T5798 6834-6835 , denotes ,
T5799 6836-6841 VBN denotes known
T5800 6842-6844 IN denotes as
T5801 6845-6849 NNP denotes WWOX
T5802 6849-6850 , denotes ,
T5803 6851-6854 IN denotes FOR
T5804 6854-6855 , denotes ,
T5805 6856-6858 CC denotes or
T5806 6859-6863 NNP denotes WOX1
T5807 6863-6864 , denotes ,
T5808 6865-6867 VBZ denotes is
T5809 6868-6875 VBN denotes encoded
T5810 6876-6878 IN denotes by
T5811 6879-6884 JJ denotes human
T5812 6885-6887 CC denotes or
T5813 6888-6893 NN denotes mouse
T5814 6894-6903 NNP denotes WWOX/Wwox
T5815 6904-6908 NN denotes gene
T5816 6908-6909 . denotes .
T5817 6910-6914 DT denotes This
T5818 6915-6919 NN denotes gene
T5819 6920-6922 VBZ denotes is
T5820 6923-6930 VBN denotes located
T5821 6931-6933 IN denotes in
T5822 6934-6944 NN denotes chromosome
T5823 6945-6950 CD denotes 16q23
T5824 6950-6952 CD denotes .3
T5825 6953-6957 CD denotes 24.1
T5826 6957-6958 , denotes ,
T5827 6959-6961 DT denotes an
T5828 6962-6966 NN denotes area
T5829 6967-6972 VBN denotes known
T5830 6973-6975 IN denotes as
T5831 6976-6979 DT denotes the
T5832 6980-6986 JJ denotes common
T5833 6987-6994 JJ denotes fragile
T5834 6995-6999 NN denotes site
T5835 7000-7006 CD denotes FRA16D
T5836 7006-7007 . denotes .
T5837 7008-7011 DT denotes The
T5838 7012-7023 JJ denotes full-length
T5839 7024-7028 NNP denotes WWOX
T5840 7029-7036 NN denotes protein
T5841 7037-7039 VBZ denotes is
T5842 7040-7048 VBN denotes composed
T5843 7049-7051 IN denotes of
T5844 7052-7055 CD denotes two
T5845 7056-7066 JJ denotes N-terminal
T5846 7067-7069 NNP denotes WW
T5847 7070-7077 NNS denotes domains
T5848 7077-7078 , denotes ,
T5849 7079-7080 DT denotes a
T5850 7081-7091 JJ denotes C-terminal
T5851 7092-7103 NN denotes short-chain
T5852 7104-7111 NN denotes alcohol
T5853 7112-7135 NN denotes dehydrogenase/reductase
T5854 7136-7137 -LRB- denotes (
T5855 7137-7140 NNP denotes SDR
T5856 7140-7141 -RRB- denotes )
T5857 7142-7148 NN denotes domain
T5858 7148-7149 , denotes ,
T5859 7150-7153 CC denotes and
T5860 7154-7155 DT denotes a
T5861 7156-7168 JJ denotes proapoptotic
T5862 7169-7179 JJ denotes C-terminal
T5863 7180-7184 NN denotes tail
T5864 7185-7187 NN denotes D3
T5865 7188-7189 -LRB- denotes (
T5866 7189-7194 NNP denotes Chang
T5867 7195-7197 FW denotes et
T5868 7198-7201 FW denotes al.
T5869 7201-7202 , denotes ,
T5870 7203-7207 CD denotes 2001
T5871 7207-7208 , denotes ,
T5872 7209-7213 CD denotes 2007
T5873 7213-7214 , denotes ,
T5874 7215-7219 CD denotes 2010
T5875 7219-7220 : denotes ;
T5876 7221-7228 NNP denotes Aqeilan
T5877 7229-7231 FW denotes et
T5878 7232-7235 FW denotes al.
T5879 7235-7236 , denotes ,
T5880 7237-7241 CD denotes 2004
T5881 7241-7242 , denotes ,
T5882 7243-7247 CD denotes 2007
T5883 7247-7248 : denotes ;
T5884 7249-7253 NNP denotes Hong
T5885 7254-7256 FW denotes et
T5886 7257-7260 FW denotes al.
T5887 7260-7261 , denotes ,
T5888 7262-7266 CD denotes 2007
T5889 7266-7267 : denotes ;
T5890 7268-7273 NNP denotes Salah
T5891 7274-7276 FW denotes et
T5892 7277-7280 FW denotes al.
T5893 7280-7281 , denotes ,
T5894 7282-7286 CD denotes 2012
T5895 7286-7287 -RRB- denotes )
T5896 7288-7289 -LRB- denotes (
T5897 7289-7295 NN denotes Figure
T5898 7296-7297 CD denotes 1
T5899 7297-7298 -RRB- denotes )
T5900 7298-7299 . denotes .
T5901 7300-7304 NNP denotes WWOX
T5902 7305-7308 MD denotes may
T5903 7309-7312 VB denotes act
T5904 7313-7315 IN denotes as
T5905 7316-7318 DT denotes an
T5906 7319-7330 NN denotes alternative
T5907 7331-7339 NN denotes receptor
T5908 7340-7343 IN denotes for
T5909 7344-7347 NN denotes sex
T5910 7348-7355 JJ denotes steroid
T5911 7356-7364 NNS denotes hormones
T5912 7364-7365 , denotes ,
T5913 7366-7371 IN denotes since
T5914 7372-7375 PRP$ denotes its
T5915 7376-7379 NNP denotes SDR
T5916 7380-7386 NN denotes domain
T5917 7387-7396 VBZ denotes possesses
T5918 7397-7399 DT denotes an
T5919 7400-7404 NNP denotes NSYK
T5920 7405-7410 NN denotes motif
T5921 7411-7418 JJ denotes capable
T5922 7419-7421 IN denotes of
T5923 7422-7433 VBG denotes interacting
T5924 7434-7438 IN denotes with
T5925 7439-7447 NN denotes androgen
T5926 7448-7451 CC denotes and
T5927 7452-7460 NN denotes estrogen
T5928 7461-7462 -LRB- denotes (
T5929 7462-7467 NNP denotes Chang
T5930 7468-7470 FW denotes et
T5931 7471-7474 FW denotes al.
T5932 7474-7475 , denotes ,
T5933 7476-7481 JJ denotes 2005a
T5934 7481-7482 : denotes ;
T5935 7483-7485 NNP denotes Su
T5936 7486-7488 FW denotes et
T5937 7489-7492 FW denotes al.
T5938 7492-7493 , denotes ,
T5939 7494-7498 CD denotes 2012
T5940 7498-7499 -RRB- denotes )
T5941 7499-7500 . denotes .
T13557 7511-7520 JJ denotes Schematic
T13558 7521-7529 NNS denotes diagrams
T13559 7530-7532 IN denotes of
T13560 7533-7537 NNP denotes WWOX
T13561 7538-7547 NN denotes structure
T13562 7548-7551 CC denotes and
T13563 7552-7555 PRP$ denotes its
T13564 7556-7560 NN denotes role
T13565 7561-7563 IN denotes in
T13566 7564-7573 VBG denotes signaling
T13567 7573-7574 . denotes .
T13568 7575-7579 NNP denotes WWOX
T13569 7580-7588 VBZ denotes contains
T13570 7589-7592 CD denotes two
T13571 7593-7603 JJ denotes N-terminal
T13572 7604-7606 NNP denotes WW
T13573 7607-7614 NNS denotes domains
T13574 7614-7615 , denotes ,
T13575 7616-7617 DT denotes a
T13576 7618-7628 JJ denotes C-terminal
T13577 7629-7640 NN denotes short-chain
T13578 7641-7648 NN denotes alcohol
T13579 7649-7672 NN denotes dehydrogenase/reductase
T13580 7673-7674 -LRB- denotes (
T13581 7674-7677 NNP denotes SDR
T13582 7677-7678 -RRB- denotes )
T13583 7679-7685 NN denotes domain
T13584 7685-7686 , denotes ,
T13585 7687-7690 CC denotes and
T13586 7691-7692 DT denotes a
T13587 7693-7695 JJ denotes D3
T13588 7696-7702 NN denotes region
T13589 7702-7703 . denotes .
T13590 7704-7705 DT denotes A
T13591 7706-7713 JJ denotes nuclear
T13592 7714-7726 NN denotes localization
T13593 7727-7733 NN denotes signal
T13594 7734-7735 -LRB- denotes (
T13595 7735-7738 NNP denotes NLS
T13596 7738-7739 -RRB- denotes )
T13597 7740-7742 VBZ denotes is
T13598 7743-7745 IN denotes in
T13599 7746-7753 IN denotes between
T13600 7754-7757 DT denotes the
T13601 7758-7760 NNP denotes WW
T13602 7761-7768 NNS denotes domains
T13603 7769-7770 -LRB- denotes (
T13604 7770-7775 NNP denotes Chang
T13605 7776-7778 FW denotes et
T13606 7779-7782 FW denotes al.
T13607 7782-7783 , denotes ,
T13608 7784-7788 CD denotes 2003
T13609 7788-7789 , denotes ,
T13610 7790-7794 CD denotes 2007
T13611 7794-7795 : denotes ;
T13612 7796-7799 NNP denotes Del
T13613 7800-7804 NNP denotes Mare
T13614 7805-7807 FW denotes et
T13615 7808-7811 FW denotes al.
T13616 7811-7812 , denotes ,
T13617 7813-7817 CD denotes 2011
T13618 7817-7818 : denotes ;
T13619 7819-7824 NNP denotes Salah
T13620 7825-7827 FW denotes et
T13621 7828-7831 FW denotes al.
T13622 7831-7832 , denotes ,
T13623 7833-7837 CD denotes 2012
T13624 7837-7838 : denotes ;
T13625 7839-7841 NNP denotes Su
T13626 7842-7844 FW denotes et
T13776 7845-7848 FW denotes al.
T13777 7848-7849 , denotes ,
T13778 7850-7854 CD denotes 2012
T13779 7854-7855 : denotes ;
T13780 7856-7863 NNS denotes reviews
T13781 7863-7864 -RRB- denotes )
T13782 7864-7865 . denotes .
T13783 7866-7869 DT denotes The
T13784 7870-7873 NNP denotes SDR
T13785 7874-7880 NN denotes domain
T13786 7881-7890 VBZ denotes possesses
T13787 7891-7892 DT denotes a
T13788 7893-7913 JJ denotes mitochondria-binding
T13789 7914-7920 NN denotes region
T13790 7920-7921 . denotes .
T13791 7922-7927 EX denotes There
T13792 7928-7931 VBP denotes are
T13793 7932-7935 CD denotes two
T13794 7936-7945 JJ denotes conserved
T13795 7946-7954 NN denotes tyrosine
T13796 7955-7970 NN denotes phosphorylation
T13797 7971-7976 NNS denotes sites
T13798 7976-7977 , denotes ,
T13799 7978-7983 NNP denotes Tyr33
T13800 7984-7987 CC denotes and
T13801 7988-7994 NNP denotes Tyr287
T13802 7994-7995 . denotes .
T13803 7996-8001 JJ denotes Other
T13804 8002-8017 NN denotes phosphorylation
T13805 8018-8023 NNS denotes sites
T13806 8024-8033 VBN denotes predicted
T13807 8034-8036 IN denotes by
T13808 8037-8044 NNP denotes NetPhos
T13809 8045-8048 CD denotes 2.0
T13810 8049-8055 NNP denotes Server
T13811 8056-8059 VBP denotes are
T13812 8060-8064 NNP denotes Tyr6
T13813 8064-8065 , denotes ,
T13814 8066-8071 NNP denotes Thr12
T13815 8071-8072 , denotes ,
T13816 8073-8078 NNP denotes Ser14
T13817 8078-8079 , denotes ,
T13818 8080-8085 NNP denotes Tyr61
T13819 8085-8086 , denotes ,
T13820 8087-8093 NNP denotes Tyr293
T13821 8093-8094 , denotes ,
T13822 8095-8098 CC denotes and
T13823 8099-8105 NNP denotes Thr3B3
T13824 8105-8106 , denotes ,
T13825 8107-8119 RB denotes respectively
T13826 8119-8120 . denotes .
T13827 8121-8125 IN denotes Upon
T13828 8126-8132 NN denotes stress
T13829 8133-8144 NN denotes stimulation
T13830 8144-8145 , denotes ,
T13831 8146-8150 NNP denotes WWOX
T13832 8151-8153 VBZ denotes is
T13833 8154-8168 VBN denotes phosphorylated
T13834 8169-8171 IN denotes in
T13835 8172-8177 CD denotes Tyr33
T13836 8178-8181 CC denotes and
T13837 8182-8187 VBZ denotes binds
T13838 8188-8191 NN denotes p53
T13839 8191-8192 . denotes .
T13840 8193-8196 DT denotes The
T13841 8197-8205 JJ denotes WWOX/p53
T13842 8206-8213 JJ denotes complex
T13843 8214-8218 RB denotes then
T13844 8219-8231 VBZ denotes translocates
T13845 8232-8234 TO denotes to
T13846 8235-8247 VB denotes mitochondria
T13847 8248-8250 CC denotes or
T13848 8251-8258 NN denotes nucleus
T13849 8259-8261 TO denotes to
T13850 8262-8268 VB denotes induce
T13851 8269-8278 NN denotes apoptosis
T13852 8278-8279 . denotes .
T13853 8280-8284 NNP denotes WWOX
T13854 8285-8289 RB denotes also
T13855 8290-8295 VBZ denotes binds
T13856 8296-8300 NNP denotes PPxY
T13857 8301-8317 NN denotes motif-containing
T13858 8318-8331 NN denotes transcription
T13859 8332-8339 NNS denotes factors
T13860 8339-8340 , denotes ,
T13861 8341-8345 JJ denotes such
T13862 8346-8348 IN denotes as
T13863 8349-8354 NNP denotes RUNX2
T13864 8354-8355 , denotes ,
T13865 8356-8361 NNP denotes c-Jun
T13866 8361-8362 , denotes ,
T13867 8363-8366 CC denotes and
T13868 8367-8372 NNP denotes ERBB4
T13869 8372-8373 , denotes ,
T13870 8374-8377 IN denotes via
T13871 8378-8381 PRP$ denotes its
T13872 8382-8387 JJ denotes first
T13873 8388-8390 NNP denotes WW
T13874 8391-8397 NN denotes domain
T13875 8397-8398 , denotes ,
T13876 8399-8402 CC denotes and
T13877 8403-8406 DT denotes the
T13878 8407-8414 JJ denotes binding
T13879 8415-8421 NNS denotes blocks
T13880 8422-8425 DT denotes the
T13881 8426-8434 NN denotes activity
T13882 8435-8437 IN denotes of
T13883 8438-8443 DT denotes these
T13884 8444-8452 NNS denotes proteins
T13885 8453-8455 IN denotes by
T13886 8456-8465 VBG denotes retaining
T13887 8466-8470 PRP denotes them
T13888 8471-8473 IN denotes in
T13889 8474-8477 DT denotes the
T13890 8478-8487 NN denotes cytoplasm
T13891 8487-8488 . denotes .
T13892 8489-8493 NNP denotes WWOX
T13893 8494-8499 VBZ denotes binds
T13894 8500-8503 NNP denotes Tau
T13895 8504-8507 IN denotes via
T13896 8508-8511 PRP$ denotes its
T13897 8512-8515 NNP denotes SDR
T13898 8516-8522 NN denotes domain
T13899 8522-8523 . denotes .
T13900 8524-8528 NNP denotes WWOX
T13901 8529-8541 VBZ denotes participates
T13902 8542-8544 IN denotes in
T13903 8545-8548 DT denotes the
T13904 8549-8552 NNP denotes Wnt
T13905 8552-8553 NNP denotes /
T13906 8553-8562 JJ denotes β-catenin
T13907 8563-8569 NN denotes signal
T13908 8570-8577 NN denotes pathway
T13909 8578-8580 IN denotes by
T13910 8581-8588 JJ denotes binding
T13911 8589-8592 NNP denotes Dvl
T13912 8593-8596 CC denotes and
T13913 8597-8607 VBG denotes inhibiting
T13914 8608-8611 PRP$ denotes its
T13915 8612-8619 JJ denotes nuclear
T13916 8620-8626 NN denotes import
T13917 8626-8627 . denotes .
T13918 8628-8635 NNP denotes Phorbol
T13919 8636-8641 NN denotes ester
T13920 8642-8652 VBZ denotes stimulates
T13921 8653-8656 DT denotes the
T13922 8657-8669 NN denotes dissociation
T13923 8670-8672 IN denotes of
T13924 8673-8681 NNP denotes MEK/WWOX
T13925 8682-8689 NN denotes complex
T13926 8690-8692 IN denotes in
T13927 8693-8699 NNP denotes Jurkat
T13928 8700-8701 NNP denotes T
T13929 8702-8706 NN denotes cell
T13930 8706-8707 , denotes ,
T13931 8708-8711 CC denotes and
T13932 8712-8715 DT denotes the
T13933 8716-8724 VBN denotes released
T13934 8725-8729 NNP denotes WWOX
T13935 8730-8742 VBZ denotes translocates
T13936 8743-8745 TO denotes to
T13937 8746-8749 DT denotes the
T13938 8750-8762 NN denotes mitochondria
T13939 8763-8766 IN denotes for
T13940 8767-8774 VBG denotes causing
T13941 8775-8779 NN denotes cell
T13942 8780-8785 NN denotes death
T13943 8785-8786 . denotes .
T13944 8787-8791 NNP denotes WWOX
T13945 8792-8794 VBZ denotes is
T13946 8795-8804 VBN denotes recruited
T13947 8805-8807 TO denotes to
T13948 8808-8811 DT denotes the
T13949 8812-8820 NN denotes membrane
T13950 8821-8825 NN denotes area
T13951 8826-8828 IN denotes by
T13952 8829-8840 NN denotes association
T13953 8841-8845 IN denotes with
T13954 8846-8852 JJ denotes Hyal-2
T13955 8853-8856 CC denotes and
T13956 8857-8870 JJ denotes phospho-Ezrin
T13957 8870-8871 . denotes .
T13958 8872-8878 NN denotes Hyal-2
T13959 8879-8881 VBZ denotes is
T13960 8882-8884 DT denotes an
T13961 8885-8896 NN denotes alternative
T13962 8897-8905 NN denotes receptor
T13963 8906-8909 IN denotes for
T13964 8910-8916 NN denotes TGF-β1
T12940 8916-8917 . denotes .
T12941 8918-8920 IN denotes In
T12942 8921-8929 NN denotes response
T12943 8930-8932 TO denotes to
T12944 8933-8939 NNP denotes TGF-β1
T12945 8939-8940 , denotes ,
T12946 8941-8945 NNP denotes WWOX
T12947 8946-8951 VBZ denotes binds
T12948 8952-8958 NNP denotes Hyal-2
T12949 8959-8962 CC denotes and
T12950 8963-8968 NNS denotes forms
T12951 8969-8970 DT denotes a
T12952 8971-8978 NN denotes complex
T12953 8978-8979 , denotes ,
T12954 8980-8988 VBN denotes followed
T12955 8989-8991 IN denotes by
T12956 8992-9002 VBG denotes relocating
T12957 9003-9005 TO denotes to
T12958 9006-9009 DT denotes the
T12959 9010-9017 NN denotes nucleus
T12960 9018-9021 CC denotes and
T12961 9022-9031 VBG denotes enhancing
T12962 9032-9035 DT denotes the
T12963 9036-9047 JJ denotes SMAD-driven
T12964 9048-9056 NN denotes promoter
T12965 9057-9065 NN denotes activity
T12966 9065-9066 . denotes .
T12967 9067-9071 NNP denotes Ack1
T12968 9071-9072 , denotes ,
T12969 9073-9082 VBN denotes activated
T12970 9083-9099 JJ denotes Cdc42-associated
T12971 9100-9106 NN denotes kinase
T12972 9107-9108 CD denotes 1
T12973 9108-9109 : denotes ;
T12974 9110-9116 NNP denotes Hyal-2
T12975 9116-9117 , denotes ,
T12976 9118-9142 NN denotes hyaluronoglucosaminidase
T12977 9143-9144 CD denotes 2
T12978 9144-9145 : denotes ;
T12979 9146-9149 NNP denotes CKI
T12980 9149-9150 , denotes ,
T12981 9151-9157 NN denotes casein
T12982 9158-9164 NN denotes kinase
T12983 9164-9165 : denotes ;
T12984 9166-9169 NNP denotes GSK
T12985 9169-9170 , denotes ,
T12986 9171-9179 NN denotes glycogen
T12987 9180-9188 NN denotes synthase
T12988 9189-9195 NN denotes kinase
T12989 9195-9196 : denotes ;
T12990 9197-9200 NNP denotes PKA
T12991 9200-9201 , denotes ,
T12992 9202-9209 NN denotes protein
T12993 9210-9216 NN denotes kinase
T12994 9217-9219 NN denotes A.
T5942 9220-9230 NN denotes Expression
T5943 9231-9233 IN denotes of
T5944 9234-9238 NNP denotes WWOX
T5945 9239-9241 VBZ denotes is
T5946 9242-9248 RB denotes either
T5947 9249-9256 VBN denotes altered
T5948 9257-9259 CC denotes or
T5949 9260-9264 VBN denotes lost
T5950 9265-9269 IN denotes from
T5951 9270-9280 JJ denotes epigenetic
T5952 9281-9293 NN denotes modification
T5953 9294-9296 IN denotes in
T5954 9297-9305 JJ denotes multiple
T5955 9306-9315 JJ denotes malignant
T5956 9316-9323 NNS denotes cancers
T5957 9323-9324 , denotes ,
T5958 9325-9329 JJ denotes such
T5959 9330-9332 IN denotes as
T5960 9333-9342 JJ denotes non-small
T5961 9343-9347 NN denotes cell
T5962 9348-9352 NN denotes lung
T5963 9353-9362 NN denotes carcinoma
T5964 9363-9364 -LRB- denotes (
T5965 9364-9370 NNP denotes Donati
T5966 9371-9373 FW denotes et
T5967 9374-9377 FW denotes al.
T5968 9377-9378 , denotes ,
T5969 9379-9383 CD denotes 2007
T5970 9383-9384 -RRB- denotes )
T5971 9384-9385 , denotes ,
T5972 9386-9399 JJ denotes hematopoietic
T5973 9400-9412 NNS denotes malignancies
T5974 9413-9414 -LRB- denotes (
T5975 9414-9419 NNP denotes Ishii
T5976 9420-9423 CC denotes and
T5977 9424-9432 NNP denotes Furukawa
T5978 9432-9433 , denotes ,
T5979 9434-9438 CD denotes 2004
T5980 9438-9439 -RRB- denotes )
T5981 9439-9440 , denotes ,
T5982 9441-9448 JJ denotes gastric
T5983 9449-9458 NN denotes carcinoma
T5984 9459-9460 -LRB- denotes (
T5985 9460-9467 JJ denotes Aqeilan
T5986 9468-9470 FW denotes et
T5987 9471-9474 FW denotes al.
T5988 9474-9475 , denotes ,
T5989 9476-9480 CD denotes 2004
T5990 9480-9481 -RRB- denotes )
T5991 9481-9482 , denotes ,
T5992 9483-9493 JJ denotes pancreatic
T5993 9494-9503 NN denotes carcinoma
T5994 9504-9505 -LRB- denotes (
T5995 9505-9511 NNP denotes Kuroki
T5996 9512-9514 FW denotes et
T5997 9515-9518 FW denotes al.
T5998 9518-9519 , denotes ,
T5999 9520-9524 CD denotes 2004
T6000 9524-9525 -RRB- denotes )
T6001 9525-9526 , denotes ,
T6002 9527-9533 NN denotes breast
T6003 9534-9543 NN denotes carcinoma
T6004 9544-9545 -LRB- denotes (
T6005 9545-9550 NNP denotes Guler
T6006 9551-9553 FW denotes et
T6007 9554-9557 FW denotes al.
T6008 9557-9558 , denotes ,
T6009 9559-9563 CD denotes 2004
T6010 9563-9564 : denotes ;
T6011 9565-9572 NNP denotes Aqeilan
T6012 9573-9575 FW denotes et
T6013 9576-9579 FW denotes al.
T6014 9579-9580 , denotes ,
T6015 9581-9585 CD denotes 2007
T6016 9585-9586 -RRB- denotes )
T6017 9586-9587 , denotes ,
T6018 9588-9591 CC denotes and
T6019 9592-9604 NN denotes glioblastoma
T6020 9605-9615 NNS denotes multiforme
T6021 9616-9617 -LRB- denotes (
T6022 9617-9622 NNP denotes Kosla
T6023 9623-9625 FW denotes et
T6024 9626-9629 FW denotes al.
T6025 9629-9630 , denotes ,
T6026 9631-9635 CD denotes 2011
T6027 9635-9636 -RRB- denotes )
T6028 9636-9637 . denotes .
T6029 9638-9649 NNP denotes Restoration
T6030 9650-9652 IN denotes of
T6031 9653-9657 NNP denotes WWOX
T6032 9658-9662 NN denotes gene
T6033 9663-9671 VBZ denotes prevents
T6034 9672-9675 DT denotes the
T6035 9676-9682 NN denotes growth
T6036 9683-9685 IN denotes of
T6037 9686-9690 NN denotes lung
T6038 9691-9697 NN denotes cancer
T6039 9698-9699 -LRB- denotes (
T6040 9699-9705 NNP denotes Fabbri
T6041 9706-9708 FW denotes et
T6042 9709-9712 FW denotes al.
T6043 9712-9713 , denotes ,
T6044 9714-9718 CD denotes 2005
T6045 9718-9719 -RRB- denotes )
T6046 9719-9720 , denotes ,
T6047 9721-9731 JJ denotes pancreatic
T6048 9732-9738 NN denotes cancer
T6049 9739-9740 -LRB- denotes (
T6050 9740-9748 NNP denotes Nakayama
T6051 9749-9751 FW denotes et
T6052 9752-9755 FW denotes al.
T6053 9755-9756 , denotes ,
T6054 9757-9761 CD denotes 2008
T6055 9761-9762 -RRB- denotes )
T6056 9762-9763 , denotes ,
T6057 9764-9767 CC denotes and
T6058 9768-9776 NN denotes prostate
T6059 9777-9783 NN denotes cancer
T6060 9784-9785 -LRB- denotes (
T6061 9785-9789 NNP denotes Hong
T6062 9790-9792 FW denotes et
T6063 9793-9796 FW denotes al.
T6064 9796-9797 , denotes ,
T6065 9798-9802 CD denotes 2009
T6066 9802-9803 -RRB- denotes )
T6067 9803-9804 . denotes .
T6068 9805-9808 DT denotes The
T6069 9809-9814 JJ denotes first
T6070 9815-9817 NNP denotes WW
T6071 9818-9824 NN denotes domain
T6072 9825-9827 IN denotes of
T6073 9828-9832 NNP denotes WWOX
T6074 9833-9836 MD denotes may
T6075 9837-9845 VB denotes interact
T6076 9846-9850 IN denotes with
T6077 9851-9859 NNS denotes proteins
T6078 9860-9870 VBG denotes possessing
T6079 9871-9872 DT denotes a
T6080 9873-9877 NNP denotes PPxY
T6081 9878-9883 NN denotes motif
T6082 9883-9884 -LRB- denotes (
T6083 9884-9885 PRP denotes s
T6084 9885-9886 -RRB- denotes )
T6085 9887-9891 JJ denotes such
T6086 9892-9894 IN denotes as
T6087 9895-9900 JJ denotes AP-2γ
T6088 9900-9901 , denotes ,
T6089 9902-9905 JJ denotes p73
T6090 9905-9906 , denotes ,
T6091 9907-9912 JJ denotes ErbB4
T6092 9912-9913 , denotes ,
T6093 9914-9919 NNP denotes Ezrin
T6094 9919-9920 , denotes ,
T6095 9921-9927 NNP denotes SIMPLE
T6096 9927-9928 , denotes ,
T6097 9929-9934 NNP denotes c-Jun
T6098 9934-9935 , denotes ,
T6099 9936-9941 NNP denotes RUNX4
T6100 9941-9942 , denotes ,
T6101 9943-9946 CC denotes and
T6102 9947-9951 JJ denotes many
T6103 9952-9958 NNS denotes others
T6104 9959-9960 -LRB- denotes (
T6105 9960-9965 NNP denotes Chang
T6106 9966-9968 FW denotes et
T6107 9969-9972 FW denotes al.
T6108 9972-9973 , denotes ,
T6109 9974-9978 CD denotes 2007
T6110 9978-9979 : denotes ;
T6111 9980-9985 NNP denotes Salah
T6112 9986-9988 FW denotes et
T6113 9989-9992 FW denotes al.
T6114 9992-9993 , denotes ,
T6115 9994-9998 CD denotes 2012
T6116 9998-9999 : denotes ;
T6117 10000-10002 NNP denotes Su
T6118 10003-10005 FW denotes et
T6119 10006-10009 FW denotes al.
T6120 10009-10010 , denotes ,
T6121 10011-10015 CD denotes 2012
T6122 10015-10016 : denotes ;
T6123 10017-10023 NN denotes Figure
T6124 10024-10025 CD denotes 1
T6125 10025-10026 -RRB- denotes )
T6126 10026-10027 . denotes .
T6127 10028-10039 RB denotes Transiently
T6128 10040-10053 VBN denotes overexpressed
T6129 10054-10058 NNP denotes WWOX
T6130 10059-10064 VBZ denotes binds
T6131 10065-10078 NN denotes transcription
T6132 10079-10086 NNS denotes factors
T6133 10087-10091 NNP denotes AP-2
T6134 10091-10092 , denotes ,
T6135 10093-10096 CD denotes p73
T6136 10096-10097 , denotes ,
T6137 10098-10101 CC denotes and
T6138 10102-10107 NNP denotes c-Jun
T6139 10108-10111 CC denotes and
T6140 10112-10117 VB denotes block
T6141 10118-10123 PRP$ denotes their
T6142 10124-10131 JJ denotes nuclear
T6143 10132-10142 NN denotes relocation
T6144 10143-10145 IN denotes in
T6145 10146-10151 NN denotes vitro
T6146 10151-10152 , denotes ,
T6147 10153-10158 WDT denotes which
T6148 10159-10169 VBZ denotes suppresses
T6149 10170-10176 NN denotes cancer
T6150 10177-10181 NN denotes cell
T6151 10182-10190 NN denotes survival
T6152 10191-10192 -LRB- denotes (
T6153 10192-10197 JJ denotes Salah
T6154 10198-10200 FW denotes et
T6155 10201-10204 FW denotes al.
T6156 10204-10205 , denotes ,
T6157 10206-10210 CD denotes 2012
T6158 10210-10211 -RRB- denotes )
T6159 10211-10212 . denotes .
T6160 10213-10215 IN denotes In
T6161 10216-10221 JJ denotes stark
T6162 10222-10230 NN denotes contrast
T6163 10230-10231 , denotes ,
T6164 10232-10236 NNP denotes Wwox
T6165 10237-10248 NNS denotes co-migrates
T6166 10249-10253 IN denotes with
T6167 10254-10266 JJ denotes proapoptotic
T6168 10267-10270 CC denotes and
T6169 10271-10283 JJ denotes pro-survival
T6170 10284-10297 NN denotes transcription
T6171 10298-10305 NNS denotes factors
T6172 10306-10308 TO denotes to
T6173 10309-10312 DT denotes the
T6174 10313-10319 NN denotes nuclei
T6175 10320-10322 IN denotes of
T6176 10323-10330 NNS denotes neurons
T6177 10331-10335 IN denotes upon
T6178 10336-10343 JJ denotes sciatic
T6179 10344-10349 NN denotes nerve
T6180 10350-10357 NN denotes axotomy
T6181 10358-10360 IN denotes in
T6182 10361-10365 NNS denotes rats
T6183 10366-10367 -LRB- denotes (
T6184 10367-10369 NNP denotes Li
T6185 10370-10372 FW denotes et
T6186 10373-10376 FW denotes al.
T6187 10376-10377 , denotes ,
T6188 10378-10382 CD denotes 2009
T6189 10382-10383 -RRB- denotes )
T6190 10383-10384 . denotes .
T6191 10385-10387 DT denotes No
T6192 10388-10396 VBG denotes blocking
T6193 10397-10399 IN denotes of
T6194 10400-10413 NN denotes translocation
T6195 10414-10416 IN denotes of
T6196 10417-10430 NN denotes transcription
T6197 10431-10438 NNS denotes factors
T6198 10439-10441 TO denotes to
T6199 10442-10445 DT denotes the
T6200 10446-10452 NN denotes nuclei
T6201 10453-10455 IN denotes by
T6202 10456-10460 NNP denotes Wwox
T6203 10461-10464 VBD denotes was
T6204 10465-10473 VBN denotes observed
T6205 10473-10474 . denotes .
T6206 10475-10480 IN denotes Under
T6207 10481-10487 NN denotes stress
T6208 10488-10498 NNS denotes conditions
T6209 10498-10499 , denotes ,
T6210 10500-10504 NNP denotes WWOX
T6211 10505-10507 VBZ denotes is
T6212 10508-10517 VBN denotes activated
T6213 10518-10521 IN denotes via
T6214 10522-10537 NN denotes phosphorylation
T6215 10538-10540 IN denotes at
T6216 10541-10546 NNP denotes Tyr33
T6217 10546-10547 , denotes ,
T6218 10548-10551 CC denotes and
T6219 10552-10557 VBZ denotes binds
T6220 10558-10566 NNS denotes proteins
T6221 10567-10580 RB denotes independently
T6222 10581-10583 IN denotes of
T6223 10584-10587 DT denotes the
T6224 10588-10592 NNP denotes PPxY
T6225 10593-10598 NN denotes motif
T6226 10599-10600 -LRB- denotes (
T6227 10600-10605 NNP denotes Chang
T6228 10606-10608 FW denotes et
T6229 10609-10612 FW denotes al.
T6230 10612-10613 , denotes ,
T6231 10614-10618 CD denotes 2001
T6232 10618-10619 , denotes ,
T6233 10620-10624 CD denotes 2003
T6234 10624-10625 , denotes ,
T6235 10626-10631 CD denotes 2005a
T6236 10631-10632 , denotes ,
T6237 10632-10633 NN denotes b
T6238 10633-10634 , denotes ,
T6239 10635-10639 CD denotes 2007
T6240 10639-10640 , denotes ,
T6241 10641-10645 CD denotes 2010
T6242 10645-10646 -RRB- denotes )
T6243 10646-10647 . denotes .
T6244 10648-10657 VBN denotes Activated
T6245 10658-10662 NNP denotes WWOX
T6246 10663-10673 RB denotes physically
T6247 10674-10683 VBZ denotes interacts
T6248 10684-10688 IN denotes with
T6249 10689-10695 NN denotes serine
T6250 10696-10713 JJ denotes 46-phosphorylated
T6251 10714-10717 NN denotes p53
T6252 10718-10719 -LRB- denotes (
T6253 10719-10725 NN denotes Figure
T6254 10726-10727 CD denotes 1
T6255 10727-10728 -RRB- denotes )
T6256 10728-10729 , denotes ,
T6257 10730-10735 WDT denotes which
T6258 10736-10746 VBZ denotes stabilizes
T6259 10747-10750 NN denotes p53
T6260 10751-10754 CC denotes and
T6261 10755-10758 PRP$ denotes its
T6262 10759-10768 JJ denotes apoptotic
T6263 10769-10777 NN denotes function
T6264 10778-10779 -LRB- denotes (
T6265 10779-10784 NNP denotes Chang
T6266 10785-10787 FW denotes et
T6267 10788-10791 FW denotes al.
T6268 10791-10792 , denotes ,
T6269 10793-10798 JJ denotes 2005b
T6270 10798-10799 -RRB- denotes )
T6271 10799-10800 . denotes .
T6272 10801-10805 RB denotes Also
T6273 10805-10806 , denotes ,
T6274 10807-10811 NNP denotes WWOX
T6275 10812-10817 VBZ denotes binds
T6276 10818-10828 JJ denotes Disheveled
T6277 10829-10837 NNS denotes proteins
T6278 10838-10839 -LRB- denotes (
T6279 10839-10842 NNP denotes Dvl
T6280 10842-10843 -RRB- denotes )
T6281 10843-10844 , denotes ,
T6282 10845-10850 WDT denotes which
T6283 10851-10854 VBP denotes are
T6284 10855-10858 JJ denotes key
T6285 10859-10869 NNS denotes components
T6286 10870-10872 IN denotes in
T6287 10873-10876 NNP denotes Wnt
T6288 10876-10877 NNP denotes /
T6289 10877-10886 JJ denotes β-catenin
T6290 10887-10896 VBG denotes signaling
T6291 10897-10904 NN denotes pathway
T6292 10905-10906 -LRB- denotes (
T6293 10906-10912 NN denotes Figure
T6294 10913-10914 CD denotes 1
T6295 10914-10915 -RRB- denotes )
T6296 10915-10916 . denotes .
T6297 10917-10919 DT denotes No
T6298 10920-10924 NN denotes PPxY
T6299 10925-10930 NN denotes motif
T6300 10931-10933 VBZ denotes is
T6301 10934-10936 IN denotes in
T6302 10937-10940 NNP denotes Dvl
T6303 10940-10941 . denotes .
T6304 10942-10953 RB denotes Transiently
T6305 10954-10967 VBN denotes overexpressed
T6306 10968-10972 NNP denotes WWOX
T6307 10973-10983 NNS denotes sequesters
T6308 10984-10989 NN denotes Dvl-2
T6309 10990-10992 IN denotes in
T6310 10993-10996 DT denotes the
T6311 10997-11006 NN denotes cytoplasm
T6312 11007-11010 CC denotes and
T6313 11011-11018 RB denotes thereby
T6314 11019-11025 NNS denotes blocks
T6315 11026-11040 JJ denotes Dvl-2-mediated
T6316 11041-11044 NNP denotes TCF
T6317 11045-11060 JJ denotes transcriptional
T6318 11061-11069 NN denotes activity
T6319 11070-11071 -LRB- denotes (
T6320 11071-11080 NNP denotes Bouteille
T6321 11081-11083 FW denotes et
T6322 11084-11087 FW denotes al.
T6323 11087-11088 , denotes ,
T6324 11089-11093 CD denotes 2009
T6325 11093-11094 -RRB- denotes )
T6326 11094-11095 . denotes .
T6327 11096-11109 NNP denotes Overexpressed
T6328 11110-11114 NNP denotes WWOX
T6329 11115-11122 VBZ denotes induces
T6330 11123-11132 NN denotes apoptosis
T6331 11133-11136 CC denotes and
T6332 11137-11145 NNS denotes inhibits
T6333 11146-11159 NN denotes proliferation
T6334 11160-11162 IN denotes of
T6335 11163-11168 JJ denotes human
T6336 11169-11176 JJ denotes hepatic
T6337 11177-11186 NN denotes carcinoma
T6338 11187-11192 NNS denotes cells
T6339 11193-11194 -LRB- denotes (
T6340 11194-11196 NNP denotes Hu
T6341 11197-11199 FW denotes et
T6342 11200-11203 FW denotes al.
T6343 11203-11204 , denotes ,
T6344 11205-11209 CD denotes 2012
T6345 11209-11210 -RRB- denotes )
T6346 11211-11214 CC denotes and
T6347 11215-11219 JJ denotes many
T6348 11220-11226 NN denotes cancer
T6349 11227-11231 NN denotes cell
T6350 11232-11237 NNS denotes types
T6351 11238-11239 -LRB- denotes (
T6352 11239-11244 NNP denotes Chang
T6353 11245-11247 FW denotes et
T6354 11248-11251 FW denotes al.
T6355 11251-11252 , denotes ,
T6356 11253-11257 CD denotes 2007
T6357 11257-11258 , denotes ,
T6358 11259-11263 CD denotes 2010
T6359 11263-11264 : denotes ;
T6360 11265-11270 NNP denotes Salah
T6361 11271-11273 FW denotes et
T6362 11274-11277 FW denotes al.
T6363 11277-11278 , denotes ,
T6364 11279-11283 CD denotes 2012
T6365 11283-11284 : denotes ;
T6366 11285-11287 NNP denotes Su
T6367 11288-11290 FW denotes et
T6368 11291-11294 FW denotes al.
T6369 11294-11295 , denotes ,
T6370 11296-11300 CD denotes 2012
T6371 11300-11301 -RRB- denotes )
T6372 11301-11302 . denotes .
T6373 11303-11307 NNP denotes WWOX
T6374 11308-11316 VBZ denotes enhances
T6375 11317-11320 DT denotes the
T6376 11321-11330 JJ denotes cytotoxic
T6377 11331-11339 NN denotes function
T6378 11340-11342 IN denotes of
T6379 11343-11348 NN denotes tumor
T6380 11349-11357 NN denotes necrosis
T6381 11358-11364 NN denotes factor
T6382 11365-11367 IN denotes by
T6383 11368-11383 JJ denotes down-regulating
T6384 11384-11393 NN denotes apoptosis
T6385 11394-11403 NN denotes inhibitor
T6386 11404-11409 NN denotes Bcl-2
T6387 11410-11413 CC denotes and
T6388 11414-11420 JJ denotes Bcl-xL
T6389 11421-11424 CC denotes and
T6390 11425-11438 JJ denotes up-regulating
T6391 11439-11448 JJ denotes apoptotic
T6392 11449-11452 NN denotes p53
T6393 11453-11454 -LRB- denotes (
T6394 11454-11459 NNP denotes Chang
T6395 11460-11462 FW denotes et
T6396 11463-11466 FW denotes al.
T6397 11466-11467 , denotes ,
T6398 11468-11472 CD denotes 2001
T6399 11472-11473 -RRB- denotes )
T6400 11473-11474 . denotes .
T6401 11475-11479 RB denotes Also
T6402 11479-11480 , denotes ,
T6403 11481-11485 NNP denotes WWOX
T6404 11486-11494 VBZ denotes mediates
T6405 11495-11499 NN denotes cell
T6406 11500-11505 NN denotes death
T6407 11506-11521 RB denotes synergistically
T6408 11522-11526 IN denotes with
T6409 11527-11530 NN denotes p53
T6410 11530-11531 . denotes .
T6411 11532-11536 IN denotes Upon
T6412 11537-11545 NN denotes exposure
T6413 11546-11548 TO denotes to
T6414 11549-11558 NNS denotes chemicals
T6415 11559-11561 CC denotes or
T6416 11562-11575 JJ denotes environmental
T6417 11576-11582 NN denotes stress
T6418 11582-11583 , denotes ,
T6419 11584-11588 JJ denotes such
T6420 11589-11591 IN denotes as
T6421 11592-11594 NNP denotes UV
T6422 11595-11606 NN denotes irradiation
T6423 11607-11610 CC denotes and
T6424 11611-11627 JJ denotes chemotherapeutic
T6425 11628-11633 NNS denotes drugs
T6426 11633-11634 , denotes ,
T6427 11635-11639 NNP denotes WWOX
T6428 11640-11649 VBZ denotes undergoes
T6429 11650-11665 NN denotes phosphorylation
T6430 11666-11668 IN denotes in
T6431 11669-11674 NNP denotes Tyr33
T6432 11675-11678 CC denotes and
T6433 11679-11687 RB denotes probably
T6434 11688-11694 NNS denotes others
T6435 11695-11700 NNS denotes sites
T6436 11700-11701 , denotes ,
T6437 11702-11710 VBN denotes followed
T6438 11711-11713 IN denotes by
T6439 11714-11724 VBG denotes relocating
T6440 11725-11727 TO denotes to
T6441 11728-11740 NN denotes mitochondria
T6442 11741-11743 CC denotes or
T6443 11744-11750 NN denotes nuclei
T6444 11751-11754 IN denotes for
T6445 11755-11763 VBG denotes inducing
T6446 11764-11773 NN denotes apoptosis
T6447 11774-11775 -LRB- denotes (
T6448 11775-11780 NNP denotes Chang
T6449 11781-11783 FW denotes et
T6450 11784-11787 FW denotes al.
T6451 11787-11788 , denotes ,
T6452 11789-11793 CD denotes 2007
T6453 11793-11794 , denotes ,
T6454 11795-11799 CD denotes 2010
T6455 11799-11800 -RRB- denotes )
T6456 11800-11801 . denotes .
T6457 11802-11806 NNP denotes WWOX
T6458 11807-11812 VBZ denotes binds
T6459 11813-11816 NNP denotes MEK
T6460 11817-11819 IN denotes in
T6461 11820-11826 NNP denotes Jurkat
T6462 11827-11828 NNP denotes T
T6463 11829-11834 NNS denotes cells
T6464 11835-11836 -LRB- denotes (
T6465 11836-11839 NNP denotes Lin
T6466 11840-11842 FW denotes et
T6467 11843-11846 FW denotes al.
T6468 11846-11847 , denotes ,
T6469 11848-11852 CD denotes 2011
T6470 11852-11853 -RRB- denotes )
T6471 11853-11854 . denotes .
T6472 11855-11862 NNP denotes Phorbol
T6473 11863-11872 NN denotes myristate
T6474 11873-11880 NN denotes acetate
T6475 11881-11882 -LRB- denotes (
T6476 11882-11885 NNP denotes PMA
T6477 11885-11886 -RRB- denotes )
T6478 11887-11898 VBZ denotes dissociates
T6479 11899-11902 DT denotes the
T6480 11903-11911 NNP denotes MEK/WWOX
T6481 11912-11919 NN denotes complex
T6482 11920-11923 CC denotes and
T6483 11924-11931 VBZ denotes induces
T6484 11932-11936 NNP denotes WWOX
T6485 11937-11939 TO denotes to
T6486 11940-11951 VB denotes translocate
T6487 11952-11954 TO denotes to
T6488 11955-11958 DT denotes the
T6489 11959-11971 NN denotes mitochondria
T6490 11972-11974 TO denotes to
T6491 11975-11981 VB denotes induce
T6492 11982-11991 NN denotes apoptosis
T6493 11991-11992 , denotes ,
T6494 11993-12000 IN denotes whereas
T6495 12001-12004 NNP denotes MEK
T6496 12005-12014 VBZ denotes relocates
T6497 12015-12017 TO denotes to
T6498 12018-12021 DT denotes the
T6499 12022-12027 JJ denotes lipid
T6500 12028-12032 NN denotes raft
T6501 12032-12033 . denotes .
T6502 12034-12044 NNP denotes Inhibition
T6503 12045-12047 IN denotes of
T6504 12048-12051 NNP denotes MEK
T6505 12052-12060 NN denotes activity
T6506 12061-12070 VBZ denotes increases
T6507 12071-12082 JJ denotes TMZ-induced
T6508 12083-12094 NN denotes suppression
T6509 12095-12097 IN denotes of
T6510 12098-12104 NN denotes cancer
T6511 12105-12109 NN denotes cell
T6512 12110-12116 NN denotes growth
T6513 12117-12118 -LRB- denotes (
T6514 12118-12122 NNP denotes Holt
T6515 12123-12125 FW denotes et
T6516 12126-12129 FW denotes al.
T6517 12129-12130 , denotes ,
T6518 12131-12135 CD denotes 2012
T6519 12135-12136 -RRB- denotes )
T6520 12136-12137 . denotes .
T6521 12138-12145 JJ denotes Ectopic
T6522 12146-12156 NN denotes expression
T6523 12157-12159 IN denotes of
T6524 12160-12164 NNP denotes WWOX
T6525 12165-12167 IN denotes in
T6526 12168-12172 NNP denotes A549
T6527 12173-12178 NNS denotes cells
T6528 12179-12186 VBZ denotes induces
T6529 12187-12199 JJ denotes procaspase-3
T6530 12200-12203 CC denotes and
T6531 12204-12216 JJ denotes procaspase-9
T6532 12217-12227 NN denotes activation
T6533 12228-12231 CC denotes and
T6534 12232-12239 VBZ denotes induces
T6535 12240-12250 NN denotes cytochrome
T6536 12251-12252 NNP denotes C
T6537 12253-12262 VBG denotes releasing
T6538 12263-12267 IN denotes from
T6539 12268-12271 DT denotes the
T6540 12272-12284 NN denotes mitochondria
T6541 12285-12286 -LRB- denotes (
T6542 12286-12291 NNP denotes Zhang
T6543 12292-12294 FW denotes et
T6544 12295-12298 FW denotes al.
T6545 12298-12299 , denotes ,
T6546 12300-12305 JJ denotes 2012a
T6547 12305-12306 -RRB- denotes )
T6548 12306-12307 . denotes .
T6549 12308-12318 NN denotes Complement
T6550 12319-12322 NN denotes C1q
T6551 12323-12330 VBZ denotes induces
T6552 12331-12338 JJ denotes ectopic
T6553 12339-12343 NNP denotes WWOX
T6554 12344-12359 NN denotes phosphorylation
T6555 12360-12362 IN denotes in
T6556 12363-12368 NNP denotes Try33
T6557 12369-12372 CC denotes and
T6558 12373-12378 VBZ denotes leads
T6559 12379-12381 TO denotes to
T6560 12382-12386 NN denotes cell
T6561 12387-12396 NN denotes apoptosis
T6562 12397-12410 RB denotes independently
T6563 12411-12413 IN denotes of
T6564 12414-12417 DT denotes the
T6565 12418-12427 JJ denotes classical
T6566 12428-12438 VBP denotes complement
T6567 12439-12449 NN denotes activation
T6568 12450-12457 NN denotes pathway
T6569 12458-12459 -LRB- denotes (
T6570 12459-12463 NNP denotes Hong
T6571 12464-12466 FW denotes et
T6572 12467-12470 FW denotes al.
T6573 12470-12471 , denotes ,
T6574 12472-12476 CD denotes 2009
T6575 12476-12477 -RRB- denotes )
T6576 12477-12478 . denotes .
T6577 12479-12480 DT denotes A
T6578 12481-12488 NN denotes portion
T6579 12489-12491 IN denotes of
T6580 12492-12496 NNP denotes WWOX
T6581 12497-12499 VBZ denotes is
T6582 12500-12508 VBN denotes anchored
T6583 12509-12511 IN denotes in
T6584 12512-12515 DT denotes the
T6585 12516-12537 JJ denotes membrane/cytoskeleton
T6586 12538-12542 NN denotes area
T6587 12543-12546 IN denotes via
T6588 12547-12554 JJ denotes binding
T6589 12555-12559 IN denotes with
T6590 12560-12573 NN denotes hyaluronidase
T6591 12574-12580 NN denotes Hyal-2
T6592 12581-12582 -LRB- denotes (
T6593 12582-12585 NNP denotes Hsu
T6594 12586-12588 FW denotes et
T6595 12589-12592 FW denotes al.
T6596 12592-12593 , denotes ,
T6597 12594-12598 CD denotes 2009
T6598 12598-12599 -RRB- denotes )
T6599 12600-12603 CC denotes and
T6600 12604-12617 NNP denotes Phospho-Ezrin
T6601 12618-12619 -LRB- denotes (
T6602 12619-12622 NNP denotes Jin
T6603 12623-12625 FW denotes et
T6604 12626-12629 FW denotes al.
T6605 12629-12630 , denotes ,
T6606 12631-12635 CD denotes 2006
T6607 12635-12636 -RRB- denotes )
T6608 12636-12637 . denotes .
T6609 12638-12650 VBG denotes Transforming
T6610 12651-12657 NN denotes growth
T6611 12658-12664 NN denotes factor
T6612 12665-12667 CD denotes β1
T6613 12668-12673 NNS denotes binds
T6614 12674-12680 JJ denotes Hyal-2
T6615 12681-12683 IN denotes as
T6616 12684-12685 DT denotes a
T6617 12686-12693 NN denotes cognate
T6618 12694-12702 NN denotes receptor
T6619 12703-12705 TO denotes to
T6620 12706-12712 VB denotes signal
T6621 12713-12716 DT denotes the
T6622 12717-12726 NN denotes formation
T6623 12727-12729 IN denotes of
T6624 12730-12733 DT denotes the
T6625 12734-12743 NNP denotes WWOX/Hyal
T6626 12743-12745 CD denotes -2
T6627 12745-12746 CD denotes /
T6628 12746-12751 NNP denotes Smad4
T6629 12752-12759 NN denotes complex
T6630 12760-12762 TO denotes to
T6631 12763-12771 VB denotes relocate
T6632 12772-12774 TO denotes to
T6633 12775-12778 DT denotes the
T6634 12779-12786 NN denotes nucleus
T6635 12787-12790 IN denotes for
T6636 12791-12800 VBG denotes enhancing
T6637 12801-12804 DT denotes the
T6638 12805-12816 JJ denotes SMAD-driven
T6639 12817-12825 NN denotes promoter
T6640 12826-12834 NN denotes activity
T6641 12835-12836 -LRB- denotes (
T6642 12836-12839 NNP denotes Hsu
T6643 12840-12842 FW denotes et
T6644 12843-12846 FW denotes al.
T6645 12846-12847 , denotes ,
T6646 12848-12852 CD denotes 2009
T6647 12852-12853 -RRB- denotes )
T6648 12853-12854 . denotes .
T7155 12874-12883 VBN denotes Activated
T7156 12884-12887 NN denotes p53
T7157 12888-12896 NNS denotes mediates
T7158 12897-12906 NN denotes apoptosis
T7159 12906-12907 , denotes ,
T7160 12908-12912 NN denotes cell
T7161 12913-12918 NN denotes cycle
T7162 12919-12925 NN denotes arrest
T7163 12925-12926 , denotes ,
T7164 12927-12937 NN denotes senescence
T7165 12937-12938 , denotes ,
T7166 12939-12942 NNP denotes DNA
T7167 12943-12949 NN denotes repair
T7168 12949-12950 , denotes ,
T7169 12951-12953 CC denotes or
T7170 12954-12964 NN denotes metabolism
T7171 12965-12966 -LRB- denotes (
T7172 12966-12970 NNP denotes Lane
T7173 12971-12974 CC denotes and
T7174 12975-12981 NNP denotes Levine
T7175 12981-12982 , denotes ,
T7176 12983-12987 CD denotes 2010
T7177 12987-12988 -RRB- denotes )
T7178 12988-12989 . denotes .
T7179 12990-12993 DT denotes The
T7180 12994-13001 JJ denotes primary
T7181 13002-13012 NNS denotes structures
T7182 13013-13015 IN denotes of
T7183 13016-13019 NN denotes p53
T7184 13020-13023 CC denotes and
T7185 13024-13027 PRP$ denotes its
T7186 13028-13036 NNS denotes isoforms
T7187 13037-13040 VBP denotes are
T7188 13041-13049 VBN denotes depicted
T7189 13050-13051 -LRB- denotes (
T7190 13051-13057 NN denotes Figure
T7191 13058-13059 CD denotes 2
T7192 13059-13060 -RRB- denotes )
T7193 13060-13061 . denotes .
T7194 13062-13065 NN denotes p53
T7195 13066-13073 VBZ denotes induces
T7196 13074-13078 NN denotes cell
T7197 13079-13084 NN denotes cycle
T7198 13085-13091 NN denotes arrest
T7199 13092-13094 IN denotes by
T7200 13095-13110 VBG denotes transactivating
T7201 13111-13116 NNS denotes genes
T7202 13117-13121 JJ denotes such
T7203 13122-13124 IN denotes as
T7204 13125-13141 JJ denotes cyclin-dependent
T7205 13142-13148 NN denotes kinase
T7206 13149-13158 NN denotes inhibitor
T7207 13159-13162 CD denotes p21
T7208 13162-13163 , denotes ,
T7209 13164-13166 CC denotes or
T7210 13167-13175 NNP denotes microRNA
T7211 13176-13181 NNP denotes miR34
T7212 13181-13182 . denotes .
T7213 13183-13186 NN denotes p53
T7214 13187-13194 VBZ denotes induces
T7215 13195-13204 NN denotes apoptosis
T7216 13205-13207 IN denotes by
T7217 13208-13223 VBG denotes transactivating
T7218 13224-13236 JJ denotes proapoptotic
T7219 13237-13242 NNS denotes genes
T7220 13243-13247 JJ denotes such
T7221 13248-13250 IN denotes as
T7222 13251-13254 NNP denotes BAX
T7223 13254-13255 , denotes ,
T7224 13256-13260 NNP denotes PUMA
T7225 13260-13261 , denotes ,
T7226 13262-13268 NNP denotes SCOTIN
T7227 13268-13269 , denotes ,
T7228 13270-13273 CC denotes and
T7229 13274-13277 NNP denotes FAS
T7230 13277-13278 , denotes ,
T7231 13279-13282 CC denotes and
T7232 13283-13293 VBG denotes inhibiting
T7233 13294-13297 DT denotes the
T7234 13298-13311 JJ denotes antiapoptotic
T7235 13312-13316 NN denotes gene
T7236 13317-13322 NN denotes BCL-2
T7237 13323-13324 -LRB- denotes (
T7238 13324-13328 NNP denotes Lane
T7239 13329-13332 CC denotes and
T7240 13333-13339 NNP denotes Levine
T7241 13339-13340 , denotes ,
T7242 13341-13345 CD denotes 2010
T7243 13345-13346 -RRB- denotes )
T7244 13346-13347 . denotes .
T7245 13348-13351 NN denotes p53
T7246 13352-13360 VBZ denotes triggers
T7247 13361-13373 JJ denotes pro-survival
T7248 13374-13376 CC denotes or
T7249 13377-13381 NN denotes cell
T7250 13382-13387 NN denotes death
T7251 13388-13396 NN denotes response
T7252 13396-13397 , denotes ,
T7253 13398-13407 VBG denotes depending
T7254 13408-13412 IN denotes upon
T7255 13413-13417 NN denotes cell
T7256 13418-13423 NNS denotes types
T7257 13423-13424 , denotes ,
T7258 13425-13428 DT denotes the
T7259 13429-13438 NN denotes intensity
T7260 13439-13441 IN denotes of
T7261 13442-13445 DT denotes the
T7262 13446-13452 NN denotes stress
T7263 13453-13459 NN denotes signal
T7264 13459-13460 , denotes ,
T7265 13461-13464 CC denotes and
T7266 13465-13468 DT denotes the
T7267 13469-13475 NN denotes extent
T7268 13476-13478 IN denotes of
T7269 13479-13487 JJ denotes cellular
T7270 13488-13494 NN denotes damage
T7271 13495-13496 -LRB- denotes (
T7272 13496-13504 NNP denotes Menendez
T7273 13505-13507 FW denotes et
T7274 13508-13511 FW denotes al.
T7275 13511-13512 , denotes ,
T7276 13513-13517 CD denotes 2009
T7277 13517-13518 -RRB- denotes )
T7278 13518-13519 . denotes .
T7279 13520-13524 RB denotes Also
T7280 13524-13525 , denotes ,
T7281 13526-13529 NN denotes p53
T7282 13530-13535 VBZ denotes plays
T7283 13536-13537 DT denotes a
T7284 13538-13542 NN denotes role
T7285 13543-13545 IN denotes in
T7286 13546-13557 VBG denotes controlling
T7287 13558-13562 NN denotes cell
T7288 13563-13571 NN denotes motility
T7289 13572-13575 IN denotes via
T7290 13576-13586 VBG denotes regulating
T7291 13587-13590 DT denotes the
T7292 13591-13601 NN denotes expression
T7293 13602-13604 IN denotes of
T7294 13605-13611 JJ denotes smooth
T7295 13612-13618 NN denotes muscle
T7296 13619-13626 NN denotes α-actin
T7297 13627-13628 -LRB- denotes (
T7298 13628-13633 NNP denotes Comer
T7299 13634-13636 FW denotes et
T7300 13637-13640 FW denotes al.
T7301 13640-13641 , denotes ,
T7302 13642-13646 CD denotes 1998
T7303 13646-13647 -RRB- denotes )
T7304 13647-13648 , denotes ,
T7305 13649-13658 VBZ denotes collagens
T7306 13659-13663 NNP denotes IIα1
T7307 13664-13667 CC denotes and
T7308 13668-13672 NNP denotes VIα1
T7309 13673-13674 -LRB- denotes (
T7310 13674-13677 NNP denotes Sun
T7311 13678-13680 FW denotes et
T7312 13681-13684 FW denotes al.
T7313 13684-13685 , denotes ,
T7314 13686-13690 CD denotes 1999
T7315 13690-13691 -RRB- denotes )
T7316 13691-13692 , denotes ,
T7317 13693-13696 CC denotes and
T7318 13697-13701 JJ denotes many
T7319 13702-13708 NNS denotes others
T7320 13708-13709 . denotes .
T14525 13720-13723 NN denotes p53
T14526 13724-13727 CC denotes and
T14527 13728-13732 NNP denotes WWOX
T14528 13733-13735 IN denotes in
T14529 13736-13739 NNP denotes GBM
T14530 13740-13744 NN denotes cell
T14531 13745-13754 NN denotes apoptosis
T14532 13754-13755 . denotes .
T14533 13756-13757 -LRB- denotes (
T14534 13757-13758 NNP denotes A
T14535 13758-13759 -RRB- denotes )
T14536 13760-13771 JJ denotes Full-length
T14537 13772-13775 NN denotes p53
T14538 13776-13785 VBZ denotes possesses
T14539 13786-13789 CD denotes two
T14540 13790-13800 JJ denotes N-terminal
T14541 13801-13816 NN denotes transactivation
T14542 13817-13823 JJ denotes acidic
T14543 13824-13831 NNS denotes domains
T14544 13831-13832 , denotes ,
T14545 13833-13834 DT denotes a
T14546 13835-13847 JJ denotes proline-rich
T14547 13848-13854 NN denotes domain
T14548 13854-13855 , denotes ,
T14549 13856-13857 DT denotes a
T14550 13858-13865 JJ denotes central
T14551 13866-13877 JJ denotes DNA-binding
T14552 13878-13884 NN denotes region
T14553 13884-13885 , denotes ,
T14554 13886-13889 CC denotes and
T14555 13890-13891 DT denotes a
T14556 13892-13902 JJ denotes C-terminal
T14557 13903-13909 NN denotes domain
T14558 13909-13910 , denotes ,
T14559 13911-13921 VBG denotes containing
T14560 13922-13923 DT denotes a
T14561 13924-13931 JJ denotes nuclear
T14562 13932-13944 NN denotes localization
T14563 13945-13951 NN denotes signal
T14564 13951-13952 , denotes ,
T14565 13953-13955 DT denotes an
T14566 13956-13971 NN denotes oligomerization
T14567 13972-13978 NN denotes domain
T14568 13978-13979 , denotes ,
T14569 13980-13983 CC denotes and
T14570 13984-13985 DT denotes a
T14571 13986-13991 JJ denotes basic
T14572 13992-13998 NN denotes region
T14573 13998-13999 . denotes .
T14574 14000-14010 JJ denotes N-terminal
T14575 14011-14019 NN denotes deletion
T14576 14020-14027 NNS denotes mutants
T14577 14028-14030 IN denotes of
T14578 14031-14034 NN denotes p53
T14579 14035-14038 VBP denotes are
T14580 14039-14043 RB denotes also
T14581 14044-14049 VBN denotes shown
T14582 14049-14050 . denotes .
T14583 14051-14052 -LRB- denotes (
T14584 14052-14053 NNP denotes B
T14585 14053-14054 -RRB- denotes )
T14586 14055-14060 CD denotes Three
T14587 14061-14067 JJ denotes likely
T14588 14068-14077 NNS denotes scenarios
T14589 14078-14081 VBP denotes are
T14590 14082-14090 VBN denotes proposed
T14591 14091-14094 IN denotes for
T14592 14095-14099 NNP denotes WWOX
T14593 14100-14103 CC denotes and
T14594 14104-14107 NN denotes p53
T14595 14108-14110 TO denotes to
T14596 14111-14119 VB denotes regulate
T14597 14120-14123 NNP denotes GBM
T14598 14124-14128 NN denotes cell
T14599 14129-14134 NN denotes death
T14600 14134-14135 . denotes .
T14601 14136-14141 RB denotes First
T14602 14141-14142 , denotes ,
T14603 14143-14150 JJ denotes ectopic
T14604 14151-14155 NNP denotes WWOX
T14605 14156-14161 VBZ denotes fails
T14606 14162-14164 TO denotes to
T14607 14165-14171 VB denotes induce
T14608 14172-14181 NN denotes apoptosis
T14609 14182-14184 IN denotes of
T14610 14185-14188 NNP denotes GBM
T14611 14189-14194 NNS denotes cells
T14612 14195-14205 VBG denotes expressing
T14613 14206-14216 JJ denotes endogenous
T14614 14217-14221 JJ denotes wild
T14615 14222-14226 NN denotes type
T14616 14227-14230 NN denotes p53
T14617 14230-14231 . denotes .
T14618 14232-14234 PRP denotes It
T14619 14235-14242 VBZ denotes appears
T14620 14243-14247 IN denotes that
T14621 14248-14255 JJ denotes ectopic
T14622 14256-14260 NNP denotes WWOX
T14623 14261-14266 NNS denotes binds
T14624 14267-14270 CC denotes and
T14625 14271-14283 RB denotes functionally
T14626 14284-14295 NNS denotes antagonizes
T14627 14296-14299 NN denotes p53
T14628 14299-14300 , denotes ,
T14629 14301-14304 CC denotes and
T14630 14305-14309 DT denotes both
T14631 14310-14318 NNS denotes proteins
T14632 14319-14326 VBP denotes nullify
T14633 14327-14331 DT denotes each
T14634 14332-14337 JJ denotes other
T14635 14340-14348 NN denotes function
T14636 14349-14351 IN denotes in
T14637 14352-14360 VBG denotes inducing
T14638 14361-14370 NN denotes apoptosis
T14639 14370-14371 . denotes .
T14640 14372-14378 NNP denotes Second
T14641 14378-14379 , denotes ,
T14642 14380-14382 DT denotes no
T14643 14383-14391 JJ denotes physical
T14644 14392-14404 NNS denotes interactions
T14645 14405-14412 IN denotes between
T14646 14413-14419 JJ denotes mutant
T14647 14420-14423 NN denotes p53
T14648 14424-14432 NNS denotes proteins
T14649 14433-14436 CC denotes and
T14650 14437-14441 NNP denotes WWOX
T14651 14442-14445 VBP denotes are
T14652 14446-14454 VBN denotes expected
T14653 14455-14457 IN denotes in
T14654 14458-14461 NNP denotes GBM
T14655 14462-14467 NNS denotes cells
T14656 14467-14468 . denotes .
T14657 14469-14473 RB denotes Thus
T14658 14473-14474 , denotes ,
T14659 14475-14482 JJ denotes ectopic
T14660 14483-14487 NNP denotes WWOX
T14661 14488-14494 VB denotes induce
T14662 14495-14504 NN denotes apoptosis
T14663 14505-14507 IN denotes in
T14664 14508-14514 JJ denotes mutant
T14665 14515-14529 JJ denotes p53-expressing
T14666 14530-14535 NNS denotes cells
T14667 14535-14536 . denotes .
T14668 14537-14544 RB denotes Finally
T14669 14544-14545 , denotes ,
T14670 14546-14553 IN denotes whether
T14671 14554-14558 NNP denotes WWOX
T14672 14559-14564 VBZ denotes binds
T14673 14565-14568 NN denotes p53
T14674 14569-14577 NNS denotes isoforms
T14675 14578-14580 VBZ denotes is
T14676 14581-14588 JJ denotes unknown
T14677 14588-14589 . denotes .
T14678 14590-14594 RB denotes Also
T14679 14594-14595 , denotes ,
T14680 14596-14603 IN denotes whether
T14681 14604-14611 JJ denotes ectopic
T14682 14612-14616 NNP denotes WWOX
T14683 14617-14626 NN denotes induction
T14684 14627-14629 IN denotes of
T14685 14630-14639 NN denotes apoptosis
T14686 14640-14642 IN denotes in
T14687 14643-14646 NNP denotes GBM
T14688 14647-14652 NNS denotes cells
T14689 14653-14663 VBG denotes expressing
T14690 14664-14667 NN denotes p53
T14691 14668-14676 NNS denotes isoforms
T14692 14677-14684 VBZ denotes remains
T14693 14685-14687 TO denotes to
T14694 14688-14690 VB denotes be
T14695 14691-14702 VBN denotes established
T14696 14702-14703 . denotes .
T14697 14704-14707 NN denotes TAD
T14698 14707-14708 , denotes ,
T14699 14709-14724 NN denotes transactivation
T14700 14725-14731 NN denotes domain
T14701 14731-14732 : denotes ;
T14702 14733-14736 NNP denotes PrD
T14703 14736-14737 , denotes ,
T14704 14738-14745 NN denotes proline
T14705 14746-14752 NN denotes domain
T14706 14752-14753 : denotes ;
T14707 14754-14757 NNP denotes NLS
T14708 14757-14758 , denotes ,
T14709 14759-14766 JJ denotes nuclear
T14710 14767-14779 NN denotes localization
T14711 14780-14786 NN denotes signal
T14712 14786-14787 : denotes ;
T14713 14788-14790 NNP denotes OD
T14714 14790-14791 , denotes ,
T14715 14792-14807 NN denotes oligomerization
T14716 14808-14814 NN denotes domain
T14717 14814-14815 : denotes ;
T14718 14816-14818 NNP denotes BR
T14719 14818-14819 , denotes ,
T14720 14820-14825 JJ denotes basic
T14721 14826-14832 NN denotes region
T14722 14832-14833 . denotes .
T7989 14848-14850 IN denotes At
T7990 14851-14856 JJS denotes least
T7991 14857-14861 CD denotes nine
T7992 14862-14870 NNS denotes isoforms
T7993 14871-14873 IN denotes of
T7994 14874-14877 NN denotes p53
T7995 14878-14882 VBP denotes have
T7996 14883-14887 VBN denotes been
T7997 14888-14898 VBN denotes identified
T7998 14899-14902 JJ denotes due
T7999 14903-14905 TO denotes to
T8000 14906-14917 JJ denotes alternative
T8001 14918-14922 NNP denotes mRNA
T8002 14923-14931 NN denotes splicing
T8003 14931-14932 , denotes ,
T8004 14933-14941 JJ denotes multiple
T8005 14942-14946 NN denotes gene
T8006 14947-14956 NNS denotes promoters
T8007 14956-14957 , denotes ,
T8008 14958-14961 CC denotes and
T8009 14962-14973 JJ denotes alternative
T8010 14974-14984 NN denotes initiation
T8011 14985-14990 NNS denotes sites
T8012 14991-14993 IN denotes of
T8013 14994-15005 NN denotes translation
T8014 15006-15007 -LRB- denotes (
T8015 15007-15012 NNP denotes Ghosh
T8016 15013-15015 FW denotes et
T8017 15016-15019 FW denotes al.
T8018 15019-15020 , denotes ,
T8019 15021-15025 CD denotes 2004
T8020 15025-15026 : denotes ;
T8021 15027-15030 NNP denotes Ray
T8022 15031-15033 FW denotes et
T8023 15034-15037 FW denotes al.
T8024 15037-15038 , denotes ,
T8025 15039-15043 CD denotes 2006
T8026 15043-15044 : denotes ;
T8027 15045-15051 NN denotes Figure
T8028 15052-15053 CD denotes 2
T8029 15053-15054 -RRB- denotes )
T8030 15054-15055 . denotes .
T8031 15056-15058 IN denotes In
T8032 15059-15066 NNS denotes cancers
T8033 15066-15067 , denotes ,
T8034 15068-15076 JJ denotes aberrant
T8035 15077-15087 NN denotes expression
T8036 15088-15090 IN denotes of
T8037 15091-15094 NN denotes p53
T8038 15095-15103 NNS denotes isoforms
T8039 15104-15110 VBZ denotes occurs
T8040 15111-15121 RB denotes frequently
T8041 15122-15123 -LRB- denotes (
T8042 15123-15130 NNP denotes Bourdon
T8043 15131-15133 FW denotes et
T8044 15134-15137 FW denotes al.
T8045 15137-15138 , denotes ,
T8046 15139-15143 CD denotes 2005
T8047 15143-15144 : denotes ;
T8048 15145-15152 NNP denotes Bourdon
T8049 15152-15153 , denotes ,
T8050 15154-15158 CD denotes 2007
T8051 15158-15159 -RRB- denotes )
T8052 15159-15160 . denotes .
T8053 15161-15172 JJ denotes Full-length
T8054 15173-15176 NN denotes p53
T8055 15176-15177 , denotes ,
T8056 15178-15185 NNP denotes Δ133p53
T8057 15185-15186 , denotes ,
T8058 15187-15190 CC denotes and
T8059 15191-15195 CD denotes p53β
T8060 15196-15199 VBP denotes are
T8061 15200-15209 VBN denotes localized
T8062 15210-15216 RB denotes mainly
T8063 15217-15219 IN denotes in
T8064 15220-15223 DT denotes the
T8065 15224-15231 NN denotes nucleus
T8066 15231-15232 , denotes ,
T8067 15233-15236 CC denotes and
T8068 15237-15241 RB denotes only
T8069 15242-15245 JJ denotes few
T8070 15246-15248 IN denotes of
T8071 15249-15253 PRP denotes them
T8072 15254-15257 VBP denotes are
T8073 15258-15260 IN denotes in
T8074 15261-15270 NN denotes cytoplasm
T8075 15270-15271 . denotes .
T8076 15272-15276 CD denotes p53γ
T8077 15277-15280 CC denotes and
T8078 15281-15289 NNP denotes Δ133p53β
T8079 15290-15293 VBP denotes are
T8080 15294-15303 VBN denotes localized
T8081 15304-15306 IN denotes in
T8082 15307-15310 DT denotes the
T8083 15311-15318 NN denotes nucleus
T8084 15319-15322 CC denotes and
T8085 15323-15332 NN denotes cytoplasm
T8086 15332-15333 . denotes .
T8087 15334-15342 NNP denotes Δ133p53γ
T8088 15343-15345 VBZ denotes is
T8089 15346-15355 VBN denotes localized
T8090 15356-15358 IN denotes in
T8091 15359-15362 DT denotes the
T8092 15363-15372 NN denotes cytoplasm
T8093 15373-15374 -LRB- denotes (
T8094 15374-15381 NNP denotes Bourdon
T8095 15382-15384 FW denotes et
T8096 15385-15388 FW denotes al.
T8097 15388-15389 , denotes ,
T8098 15390-15394 CD denotes 2005
T8099 15394-15395 -RRB- denotes )
T8100 15395-15396 . denotes .
T8101 15397-15412 NN denotes Co-transfection
T8102 15413-15415 IN denotes of
T8103 15416-15419 NN denotes p53
T8104 15420-15423 CC denotes and
T8105 15424-15428 JJ denotes p53β
T8106 15429-15438 NNS denotes increases
T8107 15439-15451 JJ denotes p53-mediated
T8108 15452-15461 NN denotes apoptosis
T8109 15461-15462 , denotes ,
T8110 15463-15470 IN denotes whereas
T8111 15471-15484 NN denotes co-expression
T8112 15485-15487 IN denotes of
T8113 15488-15491 NN denotes p53
T8114 15492-15496 IN denotes with
T8115 15497-15504 JJ denotes Δ133p53
T8116 15505-15515 NNS denotes suppresses
T8117 15516-15528 JJ denotes p53-mediated
T8118 15529-15538 NN denotes apoptosis
T8119 15539-15540 -LRB- denotes (
T8120 15540-15547 NNP denotes Bourdon
T8121 15548-15550 FW denotes et
T8122 15551-15554 FW denotes al.
T8123 15554-15555 , denotes ,
T8124 15556-15560 CD denotes 2005
T8125 15560-15561 -RRB- denotes )
T8126 15561-15562 . denotes .
T8127 15563-15570 JJ denotes Δ133p53
T8128 15571-15585 RB denotes differentially
T8129 15586-15595 VBZ denotes regulates
T8130 15596-15600 NN denotes gene
T8131 15601-15611 NN denotes expression
T8132 15612-15614 IN denotes in
T8133 15615-15628 JJ denotes p53-dependent
T8134 15629-15632 CC denotes and
T8135 15633-15634 : denotes -
T8136 15634-15645 JJ denotes independent
T8137 15646-15653 NNS denotes manners
T8138 15654-15655 -LRB- denotes (
T8139 15655-15662 NNP denotes Aoubala
T8140 15663-15665 FW denotes et
T8141 15666-15669 FW denotes al.
T8142 15669-15670 , denotes ,
T8143 15671-15675 CD denotes 2011
T8144 15675-15676 -RRB- denotes )
T8145 15676-15677 . denotes .
T8146 15678-15691 NN denotes Co-expression
T8147 15692-15694 IN denotes of
T8148 15695-15703 NNP denotes Δ133p53β
T8149 15704-15706 CC denotes or
T8150 15707-15715 NNP denotes Δ133p53γ
T8151 15716-15720 IN denotes with
T8152 15721-15724 NN denotes p53
T8153 15725-15729 VBZ denotes does
T8154 15730-15733 RB denotes not
T8155 15734-15740 VB denotes affect
T8156 15741-15744 NN denotes p53
T8157 15745-15760 JJ denotes transcriptional
T8158 15761-15769 NN denotes activity
T8159 15770-15772 IN denotes on
T8160 15773-15776 CD denotes p21
T8161 15777-15780 CC denotes and
T8162 15781-15784 NNP denotes Bax
T8163 15785-15794 NNS denotes promoters
T8164 15794-15795 , denotes ,
T8165 15796-15798 RB denotes as
T8166 15799-15803 RB denotes well
T8167 15804-15806 IN denotes as
T8168 15807-15816 NN denotes apoptosis
T8169 15816-15817 . denotes .
T9180 15852-15855 NN denotes p53
T9181 15856-15863 NNS denotes mutants
T9182 15864-15867 VBP denotes are
T9183 15868-15878 VBN denotes considered
T9184 15879-15881 IN denotes as
T9185 15882-15893 JJ denotes unfavorable
T9186 15894-15901 NNS denotes factors
T9187 15902-15905 IN denotes for
T9188 15906-15909 DT denotes the
T9189 15910-15923 NN denotes effectiveness
T9190 15924-15926 IN denotes in
T9191 15927-15939 JJ denotes radiotherapy
T9192 15940-15943 CC denotes and
T9193 15944-15947 NNP denotes TMZ
T9194 15948-15957 NN denotes treatment
T9195 15958-15960 IN denotes in
T9196 15961-15967 NN denotes glioma
T9197 15968-15973 NNS denotes cells
T9198 15974-15975 -LRB- denotes (
T9199 15975-15982 NNP denotes Gjerset
T9200 15983-15985 FW denotes et
T9201 15986-15989 FW denotes al.
T9202 15989-15990 , denotes ,
T9203 15991-15995 CD denotes 1995
T9204 15995-15996 : denotes ;
T9205 15997-16003 NNP denotes Hirose
T9206 16004-16006 FW denotes et
T9207 16007-16010 FW denotes al.
T9208 16010-16011 , denotes ,
T9209 16012-16016 CD denotes 2001
T9210 16016-16017 : denotes ;
T9211 16018-16027 NNP denotes Squatrito
T9212 16028-16030 FW denotes et
T9213 16031-16034 FW denotes al.
T9214 16034-16035 , denotes ,
T9215 16036-16040 CD denotes 2010
T9216 16040-16041 : denotes ;
T9217 16042-16048 NNP denotes Blough
T9218 16049-16051 FW denotes et
T9219 16052-16055 FW denotes al.
T9220 16055-16056 , denotes ,
T9221 16057-16061 CD denotes 2011
T9222 16061-16062 -RRB- denotes )
T9223 16062-16063 . denotes .
T9224 16064-16068 NN denotes Loss
T9225 16069-16071 IN denotes of
T9226 16072-16082 JJ denotes functional
T9227 16083-16086 NN denotes p53
T9228 16087-16094 VBZ denotes confers
T9229 16095-16106 NN denotes sensitivity
T9230 16107-16109 TO denotes to
T9231 16110-16113 NNP denotes TMZ
T9232 16114-16116 IN denotes in
T9233 16117-16123 NN denotes glioma
T9234 16124-16129 NNS denotes cells
T9235 16129-16130 , denotes ,
T9236 16131-16138 IN denotes whereas
T9237 16139-16143 JJ denotes wild
T9238 16144-16148 NN denotes type
T9239 16149-16152 NN denotes p53
T9240 16153-16162 VBZ denotes increases
T9241 16163-16166 DT denotes the
T9242 16167-16170 NNP denotes TMZ
T9243 16171-16181 NN denotes resistance
T9244 16182-16183 -LRB- denotes (
T9245 16183-16189 JJ denotes Blough
T9246 16190-16192 FW denotes et
T9247 16193-16196 FW denotes al.
T9248 16196-16197 , denotes ,
T9249 16198-16202 CD denotes 2011
T9250 16202-16203 -RRB- denotes )
T9251 16203-16204 . denotes .
T9252 16205-16208 NN denotes p53
T9253 16209-16216 NNS denotes mutants
T9254 16217-16223 VB denotes reduce
T9255 16224-16227 NNP denotes TMZ
T9256 16228-16239 NN denotes sensitivity
T9257 16240-16242 IN denotes in
T9258 16243-16250 NNS denotes gliomas
T9259 16251-16252 -LRB- denotes (
T9260 16252-16258 JJ denotes Blough
T9261 16259-16261 FW denotes et
T9262 16262-16265 FW denotes al.
T9263 16265-16266 , denotes ,
T9264 16267-16271 CD denotes 2011
T9265 16271-16272 -RRB- denotes )
T9266 16272-16273 . denotes .
T9267 16274-16281 VBN denotes Altered
T9268 16282-16286 NNP denotes WWOX
T9269 16287-16297 NN denotes expression
T9270 16298-16300 VBZ denotes is
T9271 16301-16306 VBN denotes shown
T9272 16307-16309 IN denotes in
T9273 16310-16314 NNS denotes GBMs
T9274 16314-16315 , denotes ,
T9275 16316-16318 IN denotes in
T9276 16319-16324 WDT denotes which
T9277 16325-16339 NN denotes downregulation
T9278 16340-16342 IN denotes of
T9279 16343-16347 NNP denotes WWOX
T9280 16348-16350 VBZ denotes is
T9281 16351-16361 VBN denotes associated
T9282 16362-16366 IN denotes with
T9283 16367-16371 NN denotes loss
T9284 16372-16374 IN denotes of
T9285 16375-16389 NN denotes heterozygosity
T9286 16390-16393 CC denotes and
T9287 16394-16402 NN denotes promoter
T9288 16403-16414 NN denotes methylation
T9289 16415-16416 -LRB- denotes (
T9290 16416-16421 NNP denotes Kosla
T9291 16422-16424 FW denotes et
T9292 16425-16428 FW denotes al.
T9293 16428-16429 , denotes ,
T9294 16430-16434 CD denotes 2011
T9295 16434-16435 -RRB- denotes )
T9296 16435-16436 . denotes .
T9297 16437-16445 RB denotes Recently
T9298 16445-16446 , denotes ,
T9299 16447-16449 PRP denotes we
T9300 16450-16462 VBD denotes demonstrated
T9301 16463-16467 IN denotes that
T9302 16468-16481 VBN denotes overexpressed
T9303 16482-16486 NNP denotes WWOX
T9304 16487-16494 VBZ denotes induces
T9305 16495-16504 NN denotes apoptosis
T9306 16505-16507 IN denotes of
T9307 16508-16520 NN denotes glioblastoma
T9308 16521-16528 NN denotes U373-MG
T9309 16529-16534 NNS denotes cells
T9310 16535-16544 VBG denotes harboring
T9311 16545-16551 JJ denotes mutant
T9312 16552-16555 NN denotes p53
T9313 16556-16558 IN denotes by
T9314 16559-16566 VBG denotes causing
T9315 16567-16577 JJ denotes hypoploidy
T9316 16578-16581 CC denotes and
T9317 16582-16585 NNP denotes DNA
T9318 16586-16599 NN denotes fragmentation
T9319 16600-16601 -LRB- denotes (
T9320 16601-16607 NNP denotes Chiang
T9321 16608-16610 FW denotes et
T9322 16611-16614 FW denotes al.
T9323 16614-16615 , denotes ,
T9324 16616-16620 CD denotes 2012
T9325 16620-16621 -RRB- denotes )
T9326 16621-16622 . denotes .
T9327 16623-16630 RB denotes However
T9328 16630-16631 , denotes ,
T9329 16632-16639 JJ denotes ectopic
T9330 16640-16644 NNP denotes WWOX
T9331 16645-16648 VBZ denotes has
T9332 16649-16651 DT denotes no
T9333 16652-16658 NN denotes effect
T9334 16659-16663 IN denotes with
T9335 16664-16670 JJ denotes U87-MG
T9336 16671-16681 VBG denotes expressing
T9337 16682-16686 JJ denotes wild
T9338 16687-16691 NN denotes type
T9339 16692-16695 NN denotes p53
T9340 16695-16696 . denotes .
T9341 16697-16703 IN denotes Unlike
T9342 16704-16707 NNP denotes TMZ
T9343 16707-16708 , denotes ,
T9344 16709-16713 NNP denotes WWOX
T9345 16714-16721 VBZ denotes induces
T9346 16722-16731 NN denotes apoptosis
T9347 16732-16734 IN denotes of
T9348 16735-16742 NN denotes U373-MG
T9349 16743-16748 NNS denotes cells
T9350 16749-16752 IN denotes via
T9351 16753-16754 DT denotes a
T9352 16755-16779 JJ denotes mitochondria-independent
T9353 16780-16783 CC denotes and
T9354 16784-16805 JJ denotes caspase-3-independent
T9355 16806-16813 NN denotes pathway
T9356 16814-16815 -LRB- denotes (
T9357 16815-16821 NNP denotes Chiang
T9358 16822-16824 FW denotes et
T9359 16825-16828 FW denotes al.
T9360 16828-16829 , denotes ,
T9361 16830-16834 CD denotes 2012
T9362 16834-16835 -RRB- denotes )
T9363 16835-16836 . denotes .
T9364 16837-16842 IN denotes While
T9365 16843-16846 DT denotes the
T9366 16847-16857 VBG denotes underlying
T9367 16858-16868 NNS denotes mechanisms
T9368 16869-16872 VBP denotes are
T9369 16873-16880 JJ denotes unknown
T9370 16880-16881 , denotes ,
T9371 16882-16884 PRP denotes it
T9372 16885-16887 VBZ denotes is
T9373 16888-16898 JJ denotes reasonable
T9374 16899-16901 TO denotes to
T9375 16902-16908 VB denotes assume
T9376 16909-16913 IN denotes that
T9377 16914-16917 DT denotes the
T9378 16918-16926 NN denotes survival
T9379 16927-16929 IN denotes of
T9380 16930-16935 JJ denotes human
T9381 16936-16948 NN denotes glioblastoma
T9382 16949-16954 NNS denotes cells
T9383 16955-16962 VBZ denotes depends
T9384 16963-16967 IN denotes upon
T9385 16968-16980 NNS denotes interactions
T9386 16981-16988 IN denotes between
T9387 16989-16992 DT denotes the
T9388 16993-17009 NN denotes gain-of-function
T9389 17010-17012 IN denotes of
T9390 17013-17016 NN denotes p53
T9391 17017-17024 NNS denotes mutants
T9392 17025-17028 CC denotes and
T9393 17029-17033 NNP denotes WWOX
T9394 17033-17034 . denotes .
T9395 17035-17044 VBN denotes Activated
T9396 17045-17049 NNP denotes WWOX
T9397 17050-17055 VBZ denotes binds
T9398 17056-17060 JJ denotes wild
T9399 17061-17065 NN denotes type
T9400 17066-17069 NN denotes p53
T9401 17070-17074 IN denotes with
T9402 17075-17080 NNP denotes Ser46
T9403 17081-17096 NN denotes phosphorylation
T9404 17097-17098 -LRB- denotes (
T9405 17098-17103 NNP denotes Chang
T9406 17104-17106 FW denotes et
T9407 17107-17110 FW denotes al.
T9408 17110-17111 , denotes ,
T9409 17112-17117 JJ denotes 2005b
T9410 17117-17118 -RRB- denotes )
T9411 17118-17119 . denotes .
T9412 17120-17122 NNP denotes UV
T9413 17123-17134 NN denotes irradiation
T9414 17135-17143 VBZ denotes enhances
T9415 17144-17147 DT denotes the
T9416 17148-17155 JJ denotes binding
T9417 17156-17168 NNS denotes interactions
T9418 17168-17169 . denotes .
T9419 17170-17177 IN denotes Despite
T9420 17178-17181 DT denotes the
T9421 17182-17190 NN denotes presence
T9422 17191-17193 IN denotes of
T9423 17194-17199 NNP denotes Ser46
T9424 17200-17202 IN denotes in
T9425 17203-17209 NNP denotes Δ40p53
T9426 17209-17210 , denotes ,
T9427 17211-17218 JJ denotes binding
T9428 17219-17221 IN denotes of
T9429 17222-17226 DT denotes this
T9430 17227-17234 NN denotes protein
T9431 17235-17239 IN denotes with
T9432 17240-17244 NNP denotes WWOX
T9433 17245-17252 VBZ denotes remains
T9434 17253-17255 TO denotes to
T9435 17256-17258 VB denotes be
T9436 17259-17269 VBN denotes determined
T9437 17269-17270 . denotes .
T9438 17271-17273 PRP denotes We
T9439 17274-17283 VBP denotes postulate
T9440 17284-17288 IN denotes that
T9441 17289-17291 IN denotes in
T9442 17292-17295 NNP denotes GBM
T9443 17296-17301 NNS denotes cells
T9444 17301-17302 , denotes ,
T9445 17303-17307 DT denotes both
T9446 17308-17312 JJ denotes wild
T9447 17313-17317 NN denotes type
T9448 17318-17321 NN denotes p53
T9449 17322-17325 CC denotes and
T9450 17326-17333 JJ denotes ectopic
T9451 17334-17338 NNP denotes WWOX
T9452 17339-17347 NNS denotes proteins
T9453 17348-17354 VBP denotes appear
T9454 17355-17357 TO denotes to
T9455 17358-17362 VB denotes have
T9456 17363-17364 DT denotes a
T9457 17365-17375 JJ denotes functional
T9458 17376-17386 NN denotes antagonism
T9459 17386-17387 , denotes ,
T9460 17388-17395 RB denotes thereby
T9461 17396-17406 VBG denotes nullifying
T9462 17407-17411 DT denotes each
T9463 17412-17417 JJ denotes other
T9464 17420-17428 NN denotes function
T9465 17429-17431 IN denotes in
T9466 17432-17440 VBG denotes inducing
T9467 17441-17450 NN denotes apoptosis
T9468 17451-17452 -LRB- denotes (
T9469 17452-17458 NN denotes Figure
T9470 17459-17460 CD denotes 2
T9471 17460-17461 -RRB- denotes )
T9472 17461-17462 . denotes .
T9473 17463-17469 JJ denotes Mutant
T9474 17470-17473 NN denotes p53
T9475 17474-17482 NNS denotes proteins
T9476 17483-17486 MD denotes can
T9477 17486-17489 RB denotes not
T9478 17490-17494 NN denotes bind
T9479 17495-17502 JJ denotes ectopic
T9480 17503-17507 NNP denotes WWOX
T9481 17508-17510 IN denotes in
T9482 17511-17514 NNP denotes GBM
T9483 17515-17520 NNS denotes cells
T9484 17520-17521 , denotes ,
T9485 17522-17525 CC denotes and
T9486 17526-17530 NNP denotes WWOX
T9487 17531-17533 VBZ denotes is
T9488 17534-17538 JJ denotes able
T9489 17539-17541 TO denotes to
T9490 17542-17548 VB denotes induce
T9491 17549-17558 NN denotes apoptosis
T9492 17558-17559 . denotes .
T9493 17560-17567 IN denotes Whether
T9494 17568-17572 NNP denotes WWOX
T9495 17573-17579 VBZ denotes causes
T9496 17580-17589 NN denotes apoptosis
T9497 17590-17592 IN denotes in
T9498 17593-17596 NNP denotes GBM
T9499 17597-17607 VBG denotes expressing
T9500 17608-17611 NN denotes p53
T9501 17612-17620 NNS denotes isoforms
T9502 17621-17623 VBZ denotes is
T9503 17624-17631 JJ denotes unknown
T9504 17632-17635 CC denotes and
T9505 17636-17643 VBZ denotes remains
T9506 17644-17646 TO denotes to
T9507 17647-17649 VB denotes be
T9508 17650-17661 VBN denotes established
T9509 17661-17662 . denotes .
T9985 17677-17684 IN denotes Whether
T9986 17685-17689 NNP denotes WWOX
T9987 17690-17697 VBZ denotes affects
T9988 17698-17701 NNP denotes TMZ
T9989 17702-17713 NN denotes sensitivity
T9990 17714-17717 VBZ denotes has
T9991 17718-17723 RB denotes never
T9992 17724-17728 VBN denotes been
T9993 17729-17739 VBN denotes determined
T9994 17739-17740 . denotes .
T9995 17741-17748 VBG denotes Binding
T9996 17749-17757 NNS denotes proteins
T9997 17758-17761 IN denotes for
T9998 17762-17766 NNP denotes WWOX
T9999 17767-17773 CC denotes and/or
T10000 17774-17777 NN denotes p53
T10001 17778-17781 VBP denotes are
T10002 17782-17788 JJ denotes likely
T10003 17789-17791 TO denotes to
T10004 17792-17798 VB denotes affect
T10005 17799-17808 NN denotes apoptosis
T10006 17809-17812 CC denotes and
T10007 17813-17816 NNP denotes TMZ
T10008 17817-17828 NN denotes sensitivity
T10009 17829-17831 IN denotes in
T10010 17832-17835 NNP denotes GBM
T10011 17836-17841 NNS denotes cells
T10012 17841-17842 . denotes .
T10013 17843-17847 NNP denotes WWOX
T10014 17848-17853 VBZ denotes binds
T10015 17854-17857 NNP denotes MEK
T10016 17857-17858 , denotes ,
T10017 17859-17862 CC denotes and
T10018 17863-17867 IN denotes that
T10019 17868-17871 NNP denotes PMA
T10020 17872-17883 VBZ denotes dissociates
T10021 17884-17888 DT denotes this
T10022 17889-17896 NN denotes complex
T10023 17897-17900 IN denotes for
T10024 17901-17908 VBG denotes causing
T11245 17909-17918 NN denotes apoptosis
T11246 17919-17921 IN denotes of
T11247 17922-17923 NNP denotes T
T11248 17924-17932 NN denotes leukemia
T11249 17933-17938 NNS denotes cells
T11250 17939-17940 -LRB- denotes (
T11251 17940-17943 NNP denotes Lin
T11252 17944-17946 FW denotes et
T11253 17947-17950 FW denotes al.
T11254 17950-17951 , denotes ,
T11255 17952-17956 CD denotes 2011
T11256 17956-17957 -RRB- denotes )
T11257 17957-17958 . denotes .
T11258 17959-17963 RB denotes Thus
T11259 17963-17964 , denotes ,
T11213 17965-17976 JJ denotes appropriate
T11214 17977-17986 NNS denotes chemicals
T11215 17986-17987 , denotes ,
T11216 17988-17993 WDT denotes which
T11217 17994-17999 VBP denotes break
T11218 18000-18005 RP denotes apart
T11219 18006-18009 DT denotes the
T11220 18010-18018 NNP denotes WWOX/MEK
T11221 18019-18026 NN denotes complex
T11222 18026-18027 , denotes ,
T11223 18028-18031 VBP denotes are
T11224 18032-18040 VBN denotes expected
T11225 18041-18043 TO denotes to
T11226 18044-18049 VB denotes cause
T11227 18050-18053 NNP denotes GBM
T11228 18054-18058 NN denotes cell
T11229 18059-18064 NN denotes death
T11230 18064-18065 . denotes .
T11231 18066-18077 JJ denotes Preliminary
T11232 18078-18085 NNS denotes studies
T11233 18086-18090 IN denotes from
T11234 18091-18094 PRP$ denotes our
T11235 18095-18104 NN denotes screening
T11236 18105-18107 IN denotes of
T11237 18108-18117 NNS denotes chemicals
T11238 18118-18122 VBP denotes have
T11239 18123-18131 VBN denotes selected
T11240 18132-18139 JJ denotes certain
T11241 18140-18145 JJ denotes small
T11242 18146-18155 NNS denotes molecules
T11243 18156-18160 WDT denotes that
T11244 18161-18167 VBP denotes induce
T11599 18168-18177 NN denotes apoptosis
T11600 18178-18180 IN denotes of
T11601 18181-18185 JJ denotes many
T11602 18186-18191 NNS denotes types
T11603 18192-18194 IN denotes of
T11604 18195-18201 NN denotes cancer
T11605 18202-18207 NNS denotes cells
T11606 18208-18209 -LRB- denotes (
T11607 18209-18211 NNP denotes Lu
T11608 18212-18214 FW denotes et
T11609 18215-18218 FW denotes al.
T11610 18218-18219 , denotes ,
T11611 18220-18231 JJ denotes unpublished
T11612 18231-18232 -RRB- denotes )
T11613 18232-18233 . denotes .
T11614 18234-18240 RB denotes Indeed
T11615 18240-18241 , denotes ,
T11616 18242-18250 JJ denotes specific
T11617 18251-18261 NN denotes inhibition
T11618 18262-18264 IN denotes of
T11619 18265-18268 NNP denotes MEK
T11620 18269-18271 IN denotes by
T11621 18272-18283 NN denotes selumetinib
T11622 18284-18292 VBZ denotes enhances
T11623 18293-18304 JJ denotes TMZ-induced
T11624 18305-18311 NN denotes cancer
T11625 18312-18316 NN denotes cell
T11626 18317-18322 NN denotes death
T11627 18323-18325 IN denotes in
T11628 18326-18330 NN denotes vivo
T11629 18331-18332 -LRB- denotes (
T11630 18332-18336 NNP denotes Holt
T11631 18337-18339 FW denotes et
T11632 18340-18343 FW denotes al.
T11633 18343-18344 , denotes ,
T11634 18345-18349 CD denotes 2012
T11635 18349-18350 -RRB- denotes )
T11636 18350-18351 . denotes .
T11637 18352-18357 NNP denotes Serum
T11638 18358-18365 NNS denotes factors
T11639 18366-18369 MD denotes can
T11640 18370-18372 VB denotes be
T11641 18373-18381 VBN denotes utilized
T11642 18382-18385 IN denotes for
T11643 18386-18394 VBG denotes blocking
T11644 18395-18401 NN denotes cancer
T11645 18402-18408 NN denotes growth
T11646 18408-18409 . denotes .
T11647 18410-18413 IN denotes For
T11648 18414-18421 NN denotes example
T11649 18421-18422 , denotes ,
T11650 18423-18428 NN denotes serum
T11651 18429-18439 VBP denotes complement
T11652 18440-18443 JJ denotes C1q
T11653 18444-18451 VBZ denotes induces
T11654 18452-18461 NN denotes apoptosis
T11655 18462-18464 IN denotes of
T11656 18465-18473 NN denotes prostate
T11657 18474-18480 NN denotes cancer
T11658 18481-18484 CC denotes and
T11659 18485-18499 NNS denotes neuroblastomas
T11660 18500-18505 NNS denotes cells
T11661 18506-18513 IN denotes without
T11662 18514-18527 NN denotes participation
T11663 18528-18530 IN denotes of
T11664 18531-18541 JJ denotes downstream
T11665 18542-18550 NNS denotes proteins
T11666 18551-18553 IN denotes in
T11667 18554-18557 DT denotes the
T11668 18558-18567 JJ denotes classical
T11669 18568-18578 NN denotes activation
T11670 18579-18586 NN denotes pathway
T11671 18587-18588 -LRB- denotes (
T11672 18588-18592 NNP denotes Hong
T11673 18593-18595 FW denotes et
T11674 18596-18599 FW denotes al.
T11675 18599-18600 , denotes ,
T11676 18601-18605 CD denotes 2009
T11677 18605-18606 -RRB- denotes )
T11678 18606-18607 . denotes .
T11679 18608-18610 IN denotes In
T11680 18611-18615 DT denotes this
T11681 18616-18621 NN denotes event
T11682 18621-18622 , denotes ,
T11683 18623-18630 JJ denotes ectopic
T11684 18631-18635 NNP denotes WWOX
T11685 18636-18638 VBZ denotes is
T11686 18639-18648 VBN denotes activated
T11687 18649-18652 IN denotes for
T11688 18653-18661 VBG denotes inducing
T11689 18662-18671 NN denotes apoptosis
T11690 18671-18672 . denotes .
T11691 18673-18680 NN denotes Failure
T11692 18681-18683 IN denotes of
T11693 18684-18691 JJ denotes ectopic
T11694 18692-18696 NNP denotes WWOX
T11695 18697-18699 IN denotes in
T11696 18700-18708 VBG denotes inducing
T11697 18709-18718 NN denotes apoptosis
T11698 18719-18721 IN denotes of
T11699 18722-18728 NN denotes glioma
T11700 18729-18734 NNS denotes cells
T11701 18735-18745 VBG denotes possessing
T11702 18746-18750 JJ denotes wild
T11703 18751-18755 NN denotes type
T11704 18756-18759 NN denotes p53
T11705 18760-18762 VBZ denotes is
T11706 18763-18770 JJ denotes unusual
T11707 18771-18772 -LRB- denotes (
T11708 18772-18778 NNP denotes Chiang
T11709 18779-18781 FW denotes et
T11710 18782-18785 FW denotes al.
T11711 18785-18786 , denotes ,
T11712 18787-18791 CD denotes 2012
T11713 18791-18792 -RRB- denotes )
T11714 18792-18793 . denotes .
T11715 18794-18796 IN denotes In
T11716 18797-18801 JJS denotes most
T11717 18802-18807 NNS denotes cases
T11718 18807-18808 , denotes ,
T11719 18809-18811 PRP denotes we
T11720 18812-18816 VBP denotes have
T11721 18817-18822 VBN denotes shown
T11722 18823-18827 IN denotes that
T11723 18828-18831 NN denotes p53
T11724 18832-18844 RB denotes functionally
T11725 18845-18854 VBZ denotes interacts
T11726 18855-18859 IN denotes with
T11727 18860-18864 NNP denotes WWOX
T11728 18864-18865 , denotes ,
T11729 18866-18869 CC denotes and
T11730 18870-18874 DT denotes both
T11731 18875-18883 NNS denotes proteins
T11732 18884-18890 VBP denotes induce
T11733 18891-18900 NN denotes apoptosis
T11734 18901-18903 IN denotes in
T11735 18904-18905 DT denotes a
T11736 18906-18917 JJ denotes synergistic
T11737 18918-18924 NN denotes manner
T11738 18925-18926 -LRB- denotes (
T11739 18926-18931 NNP denotes Chang
T11740 18932-18934 FW denotes et
T11741 18935-18938 FW denotes al.
T11742 18938-18939 , denotes ,
T11743 18940-18944 CD denotes 2001
T11744 18944-18945 , denotes ,
T11745 18946-18950 CD denotes 2003
T11746 18950-18951 , denotes ,
T11747 18952-18957 CD denotes 2005a
T11748 18957-18958 , denotes ,
T11749 18958-18959 NN denotes b
T11750 18959-18960 , denotes ,
T11751 18961-18965 CD denotes 2007
T11752 18965-18966 , denotes ,
T11753 18967-18971 CD denotes 2010
T11754 18971-18972 , denotes ,
T11755 18973-18977 CD denotes 2012
T11756 18977-18978 : denotes ;
T11757 18979-18981 NNP denotes Su
T11758 18982-18984 FW denotes et
T11759 18985-18988 FW denotes al.
T11760 18988-18989 , denotes ,
T11761 18990-18994 CD denotes 2012
T11762 18994-18995 -RRB- denotes )
T11763 18995-18996 . denotes .
T11764 18997-18998 DT denotes A
T11765 18999-19005 JJ denotes likely
T11766 19006-19014 NN denotes scenario
T11767 19015-19017 VBZ denotes is
T11768 19018-19022 IN denotes that
T11769 19023-19034 JJ denotes p53-binding
T11770 19035-19043 NNS denotes proteins
T11771 19043-19044 , denotes ,
T11772 19045-19050 WDT denotes which
T11773 19051-19054 VBP denotes are
T11774 19055-19062 JJ denotes present
T11775 19063-19065 IN denotes in
T11776 19066-19070 NNS denotes GBMs
T11777 19070-19071 , denotes ,
T11778 19072-19075 MD denotes may
T11779 19076-19085 VB denotes interfere
T11780 19086-19090 IN denotes with
T11781 19091-19094 DT denotes the
T11782 19095-19104 JJ denotes apoptotic
T11783 19105-19113 NN denotes function
T11784 19114-19116 IN denotes of
T11785 19117-19121 NNP denotes WWOX
T11786 19122-19125 CC denotes and
T11787 19126-19129 NN denotes p53
T11788 19129-19130 . denotes .
T11789 19131-19141 JJ denotes Functional
T11790 19142-19152 NN denotes antagonism
T11791 19153-19158 IN denotes among
T11792 19159-19164 NN denotes tumor
T11793 19165-19176 NNS denotes suppressors
T11794 19177-19180 VBZ denotes has
T11795 19181-19186 RB denotes never
T11796 19187-19191 VBN denotes been
T11797 19192-19202 VBN denotes documented
T11798 19203-19205 IN denotes in
T11799 19206-19209 DT denotes the
T11800 19210-19220 NN denotes literature
T11801 19220-19221 . denotes .
T11802 19222-19229 RB denotes However
T11803 19229-19230 , denotes ,
T11804 19231-19233 PRP denotes it
T11805 19234-19236 VBZ denotes is
T11806 19237-19240 RB denotes not
T11807 19241-19251 JJ denotes surprising
T11808 19252-19254 TO denotes to
T11809 19255-19259 VB denotes find
T11810 19260-19264 DT denotes that
T11811 19265-19269 JJ denotes many
T11812 19270-19275 NN denotes tumor
T11813 19276-19286 NN denotes suppressor
T11814 19287-19295 NNS denotes proteins
T11815 19295-19296 , denotes ,
T11816 19297-19301 FW denotes e.g.
T11817 19301-19302 , denotes ,
T11818 19303-19306 NN denotes p53
T11819 19306-19307 , denotes ,
T11820 19308-19312 NNP denotes WWOX
T11821 19312-19313 , denotes ,
T11822 19314-19319 NNP denotes Smad4
T11823 19319-19320 , denotes ,
T11824 19321-19325 NNP denotes PTEN
T11825 19325-19326 , denotes ,
T11826 19327-19331 NNP denotes PP2A
T11827 19331-19332 , denotes ,
T11828 19333-19336 CC denotes and
T11829 19337-19341 FW denotes etc.
T11830 19341-19342 , denotes ,
T11831 19343-19346 VBP denotes are
T11832 19347-19360 RB denotes significantly
T11833 19361-19372 VBN denotes upregulated
T11834 19373-19379 IN denotes during
T11835 19380-19383 DT denotes the
T11836 19384-19389 JJ denotes early
T11837 19390-19395 NN denotes stage
T11838 19396-19398 IN denotes of
T11839 19399-19405 NN denotes cancer
T11840 19406-19417 NN denotes progression
T11841 19418-19419 -LRB- denotes (
T11842 19419-19422 NNP denotes Lai
T11843 19423-19425 FW denotes et
T11844 19426-19429 FW denotes al.
T11845 19429-19430 , denotes ,
T11846 19431-19435 CD denotes 2005
T11847 19435-19436 : denotes ;
T11848 19437-19442 NNP denotes Chang
T11849 19443-19445 FW denotes et
T11850 19446-19449 FW denotes al.
T11851 19449-19450 , denotes ,
T11852 19451-19462 JJ denotes unpublished
T11853 19462-19463 -RRB- denotes )
T11854 19463-19464 . denotes .
T11855 19465-19467 VB denotes Do
T11856 19468-19473 DT denotes these
T11857 19474-19482 NNS denotes proteins
T11858 19483-19486 VBP denotes act
T11859 19487-19502 RB denotes synergistically
T11860 19503-19505 IN denotes in
T11861 19506-19514 VBG denotes blocking
T11862 19515-19521 NN denotes cancer
T11863 19522-19533 NN denotes progression
T11864 19534-19537 CC denotes but
T11865 19538-19542 VBP denotes lose
T11866 19543-19550 NN denotes control
T11867 19551-19561 RB denotes eventually
T11868 19561-19562 . denotes ?
T11869 19563-19565 CC denotes Or
T11870 19565-19566 , denotes ,
T11871 19567-19569 VBP denotes do
T11872 19570-19574 PRP denotes they
T11873 19575-19585 VBP denotes counteract
T11874 19586-19590 DT denotes each
T11875 19591-19596 JJ denotes other
T11876 19599-19607 NN denotes function
T11877 19607-19608 , denotes ,
T11878 19609-19613 RB denotes thus
T11879 19614-19622 VBG denotes allowing
T11880 19623-19629 NN denotes cancer
T11881 19630-19636 NN denotes growth
T11882 19636-19637 . denotes ?
T11883 19638-19645 IN denotes Whether
T11884 19646-19656 JJ denotes endogenous
T11885 19657-19661 NNP denotes WWOX
T11886 19662-19673 NNS denotes counteracts
T11887 19674-19678 IN denotes with
T11888 19679-19682 DT denotes the
T11889 19683-19691 NN denotes function
T11890 19692-19694 IN denotes of
T11891 19695-19705 JJ denotes endogenous
T11892 19706-19709 NN denotes p53
T11893 19710-19712 VBZ denotes is
T11894 19713-19720 JJ denotes unknown
T11895 19721-19724 CC denotes and
T11896 19725-19732 VBZ denotes remains
T11897 19733-19735 TO denotes to
T11898 19736-19738 VB denotes be
T11899 19739-19750 VBN denotes established
T11900 19750-19751 . denotes .
T11901 19752-19755 CD denotes One
T11902 19756-19758 IN denotes of
T11903 19759-19762 DT denotes the
T11904 19763-19769 JJ denotes unique
T11905 19770-19785 NNS denotes characteristics
T11906 19786-19789 IN denotes for
T11907 19790-19799 JJ denotes malignant
T11908 19800-19807 NNS denotes gliomas
T11909 19808-19810 VBZ denotes is
T11910 19811-19816 PRP$ denotes their
T11911 19817-19824 NN denotes diffuse
T11912 19825-19837 NN denotes infiltration
T11913 19838-19842 IN denotes into
T11914 19843-19850 JJ denotes distant
T11915 19851-19856 NN denotes brain
T11916 19857-19863 NN denotes tissue
T11917 19863-19864 . denotes .
T11918 19865-19871 NNP denotes Signal
T11919 19872-19880 NNS denotes pathways
T11920 19880-19881 , denotes ,
T11921 19882-19891 VBG denotes involving
T11922 19892-19896 NNP denotes PI3K
T11923 19896-19897 , denotes ,
T11924 19898-19901 NNP denotes Akt
T11925 19901-19902 , denotes ,
T11926 19903-19907 NNP denotes mTOR
T11927 19907-19908 , denotes ,
T11928 19909-19914 NNP denotes NF-κB
T11929 19914-19915 , denotes ,
T11930 19916-19919 CC denotes and
T11931 19920-19929 NN denotes autophagy
T11932 19929-19930 , denotes ,
T11933 19931-19934 VBP denotes are
T11934 19935-19943 VBN denotes believed
T11935 19944-19946 TO denotes to
T11936 19947-19953 VB denotes confer
T11937 19954-19959 DT denotes these
T11938 19960-19969 VBG denotes migrating
T11939 19970-19975 NNS denotes cells
T11940 19976-19985 JJ denotes resistant
T11941 19986-19988 TO denotes to
T11942 19989-19998 JJ denotes apoptotic
T11943 19999-20004 NN denotes death
T11944 20005-20006 -LRB- denotes (
T11945 20006-20013 NNP denotes Lefranc
T11946 20014-20016 FW denotes et
T11947 20017-20020 FW denotes al.
T11948 20020-20021 , denotes ,
T11949 20022-20026 CD denotes 2005
T11950 20026-20027 -RRB- denotes )
T11951 20027-20028 . denotes .
T11952 20029-20035 NNP denotes Glioma
T11953 20036-20041 NNS denotes cells
T11954 20042-20049 VBP denotes possess
T11955 20050-20054 NNP denotes CD44
T11956 20055-20057 IN denotes as
T11957 20058-20059 DT denotes a
T11958 20060-20068 NN denotes receptor
T11959 20069-20072 IN denotes for
T11960 20073-20084 VBG denotes interacting
T11961 20085-20089 IN denotes with
T11962 20090-20095 NN denotes brain
T11963 20096-20102 NN denotes matrix
T11964 20103-20113 NN denotes hyaluronan
T11965 20114-20115 -LRB- denotes (
T11966 20115-20120 NNP denotes Murai
T11967 20121-20123 FW denotes et
T11968 20124-20127 FW denotes al.
T11969 20127-20128 , denotes ,
T11970 20129-20133 CD denotes 2004
T11971 20133-20134 : denotes ;
T11972 20135-20142 NNP denotes Yoshida
T11973 20143-20145 FW denotes et
T11974 20146-20149 FW denotes al.
T11975 20149-20150 , denotes ,
T11976 20151-20155 CD denotes 2012
T11977 20155-20156 -RRB- denotes )
T11978 20156-20157 , denotes ,
T11979 20158-20161 CC denotes and
T11980 20162-20169 NN denotes secrete
T11981 20170-20184 NNS denotes hyaluronidases
T11982 20185-20188 CC denotes and
T11983 20189-20207 NNS denotes metalloproteinases
T11984 20208-20210 TO denotes to
T11985 20211-20221 VB denotes facilitate
T11986 20222-20227 PRP$ denotes their
T11987 20228-20237 NN denotes migration
T11988 20238-20239 -LRB- denotes (
T11989 20239-20246 NNP denotes Delpech
T11990 20247-20249 FW denotes et
T11991 20250-20253 FW denotes al.
T11992 20253-20254 , denotes ,
T11993 20255-20259 CD denotes 2002
T11994 20259-20260 : denotes ;
T11995 20261-20267 NNP denotes Junker
T11996 20268-20270 FW denotes et
T11997 20271-20274 FW denotes al.
T11998 20274-20275 , denotes ,
T11999 20276-20280 CD denotes 2003
T12000 20280-20281 : denotes ;
T12001 20282-20290 NNP denotes Hagemann
T12002 20291-20293 FW denotes et
T12003 20294-20297 FW denotes al.
T12004 20297-20298 , denotes ,
T12005 20299-20303 CD denotes 2012
T12006 20303-20304 -RRB- denotes )
T12007 20304-20305 . denotes .
T12008 20306-20310 RB denotes Also
T12009 20310-20311 , denotes ,
T12010 20312-20316 NN denotes lack
T12011 20317-20319 IN denotes of
T12012 20320-20324 NNP denotes WWOX
T12013 20325-20335 NN denotes expression
T12014 20336-20338 VBZ denotes is
T12015 20339-20347 VBN denotes expected
T12016 20348-20350 TO denotes to
T12017 20351-20358 VB denotes enhance
T12018 20359-20363 NN denotes cell
T12019 20364-20373 NN denotes migration
T12020 20373-20374 . denotes .
T12021 20375-20378 IN denotes For
T12022 20379-20386 NN denotes example
T12023 20386-20387 , denotes ,
T12024 20388-20392 NN denotes loss
T12025 20393-20395 IN denotes of
T12026 20396-20400 NNP denotes WWOX
T12027 20401-20412 VBZ denotes facilitates
T12028 20413-20422 NN denotes migration
T12029 20423-20425 IN denotes of
T12030 20426-20433 JJ denotes ovarian
T12031 20434-20440 NN denotes cancer
T12032 20441-20444 CC denotes and
T12033 20445-20457 NN denotes osteosarcoma
T12034 20458-20463 NNS denotes cells
T12035 20464-20465 -LRB- denotes (
T12036 20465-20472 NNP denotes Gourley
T12037 20473-20475 FW denotes et
T12038 20476-20479 FW denotes al.
T12039 20479-20480 , denotes ,
T12040 20481-20485 CD denotes 2009
T12041 20485-20486 : denotes ;
T12042 20487-20490 NNP denotes Del
T12043 20491-20495 NNP denotes Mare
T12044 20496-20498 FW denotes et
T12045 20499-20502 FW denotes al.
T12046 20502-20503 , denotes ,
T12047 20504-20508 CD denotes 2011
T12048 20508-20509 -RRB- denotes )
T12049 20509-20510 . denotes .
T12050 20511-20518 JJ denotes Ectopic
T12051 20519-20529 NN denotes expression
T12052 20530-20532 IN denotes of
T12053 20533-20538 CD denotes TIAF1
T12054 20539-20540 -LRB- denotes (
T12055 20540-20553 JJ denotes TGF-β-induced
T12056 20554-20567 JJ denotes antiapoptotic
T12057 20568-20574 NN denotes factor
T12058 20574-20575 -RRB- denotes )
T12059 20575-20576 , denotes ,
T12060 20577-20580 NN denotes p53
T12061 20580-20581 , denotes ,
T12062 20582-20585 CC denotes and
T12063 20586-20590 NNP denotes WWOX
T12064 20591-20601 VBZ denotes suppresses
T12065 20602-20623 JJ denotes anchorage-independent
T12066 20624-20630 NN denotes growth
T12067 20631-20634 CC denotes and
T12068 20635-20639 NN denotes cell
T12069 20640-20649 NN denotes migration
T12070 20650-20653 CC denotes and
T12071 20654-20660 VBZ denotes causes
T12072 20661-20670 NN denotes apoptosis
T12073 20671-20673 IN denotes in
T12074 20674-20680 NN denotes cancer
T12075 20681-20686 NNS denotes cells
T12076 20687-20688 -LRB- denotes (
T12077 20688-20693 NNP denotes Chang
T12078 20694-20696 FW denotes et
T12079 20697-20700 FW denotes al.
T12080 20700-20701 , denotes ,
T12081 20702-20706 CD denotes 2012
T12082 20706-20707 -RRB- denotes )
T12083 20707-20708 . denotes .
T12084 20709-20711 PRP denotes We
T12085 20712-20719 VBP denotes believe
T12086 20720-20724 IN denotes that
T12087 20725-20731 NN denotes glioma
T12088 20732-20737 NNS denotes cells
T12089 20737-20738 , denotes ,
T12090 20739-20743 IN denotes with
T12091 20744-20748 NN denotes stem
T12092 20749-20758 JJ denotes cell-like
T12093 20759-20769 NNS denotes properties
T12094 20769-20770 , denotes ,
T12095 20771-20778 VB denotes migrate
T12096 20779-20791 RB denotes individually
T12097 20792-20798 RB denotes rather
T12098 20799-20803 IN denotes than
T12099 20804-20816 RB denotes collectively
T12100 20816-20817 . denotes .
T12101 20818-20822 DT denotes This
T12102 20823-20833 NN denotes assumption
T12103 20834-20836 VBZ denotes is
T12104 20837-20842 VBN denotes based
T12105 20843-20847 IN denotes upon
T12106 20848-20851 PRP$ denotes our
T12107 20852-20864 NNS denotes observations
T12108 20865-20869 IN denotes that
T12109 20870-20875 NN denotes mouse
T12110 20876-20880 NNP denotes Wwox
T12111 20881-20885 NN denotes gene
T12112 20886-20894 NN denotes knockout
T12113 20895-20900 NNS denotes cells
T12114 20901-20902 -LRB- denotes (
T12115 20902-20906 FW denotes e.g.
T12116 20906-20907 , denotes ,
T12117 20908-20917 JJ denotes embryonic
T12118 20918-20929 NNS denotes fibroblasts
T12119 20929-20930 -RRB- denotes )
T12120 20931-20938 VBP denotes migrate
T12121 20939-20951 RB denotes individually
T12122 20952-20955 CC denotes and
T12123 20956-20968 RB denotes aggressively
T12124 20968-20969 . denotes .
T12125 20970-20972 IN denotes In
T12126 20973-20981 NN denotes contrast
T12127 20981-20982 , denotes ,
T12128 20983-20987 JJ denotes wild
T12129 20988-20992 NN denotes type
T12130 20993-20998 NNS denotes cells
T12131 20999-21006 VBP denotes migrate
T12132 21007-21019 RB denotes collectively
T12133 21020-21021 -LRB- denotes (
T12134 21021-21025 NNP denotes Chou
T12135 21026-21028 FW denotes et
T12136 21029-21032 FW denotes al.
T12137 21032-21033 , denotes ,
T12138 21034-21045 JJ denotes unpublished
T12139 21045-21046 -RRB- denotes )
T12140 21046-21047 . denotes .
T12141 21048-21053 IN denotes While
T12142 21054-21055 DT denotes a
T12143 21056-21063 NN denotes portion
T12144 21064-21066 IN denotes of
T12145 21067-21071 NNP denotes WWOX
T12146 21072-21074 VBZ denotes is
T12147 21075-21083 VBN denotes anchored
T12148 21084-21086 IN denotes on
T12149 21087-21090 DT denotes the
T12150 21091-21095 NN denotes cell
T12151 21096-21117 NN denotes membrane/cytoskeleton
T12152 21117-21118 , denotes ,
T12153 21119-21132 JJ denotes WWOX-negative
T12154 21133-21138 NNS denotes cells
T12155 21139-21143 VBP denotes lose
T12156 21144-21155 NN denotes recognition
T12157 21156-21158 IN denotes by
T12158 21159-21167 JJ denotes parental
T12159 21168-21181 JJ denotes WWOX-positive
T12160 21182-21187 NNS denotes cells
T12161 21187-21188 , denotes ,
T12162 21189-21192 CC denotes and
T12163 21193-21197 DT denotes this
T12164 21198-21207 VBZ denotes increases
T12165 21208-21211 DT denotes the
T12166 21212-21220 NN denotes mobility
T12167 21221-21223 IN denotes of
T12168 21224-21237 JJ denotes WWOX-negative
T12169 21238-21243 NNS denotes cells
T12170 21244-21246 TO denotes to
T12171 21247-21251 VB denotes move
T12172 21252-21256 RB denotes away
T12173 21257-21261 IN denotes from
T12174 21262-21265 DT denotes the
T12175 21266-21279 JJ denotes WWOX-positive
T12176 21280-21285 NNS denotes cells
T12177 21285-21286 . denotes .
T12178 21287-21298 RB denotes Conceivably
T12179 21298-21299 , denotes ,
T12180 21300-21313 JJ denotes WWOX-negative
T12181 21314-21320 NN denotes glioma
T12182 21321-21326 NNS denotes cells
T12183 21327-21334 VBP denotes migrate
T12184 21335-21347 RB denotes individually
T12185 21348-21351 CC denotes and
T12186 21352-21356 VB denotes turn
T12187 21357-21361 RB denotes away
T12188 21362-21366 IN denotes from
T12189 21367-21382 JJ denotes WWOX-expressing
T12190 21383-21388 NN denotes brain
T12191 21389-21394 NNS denotes cells
T12192 21395-21397 TO denotes to
T12193 21398-21401 JJ denotes low
T12194 21402-21406 NNP denotes WWOX
T12195 21407-21417 NN denotes expression
T12196 21418-21423 NNS denotes areas
T12197 21423-21424 . denotes .
T12198 21425-21435 RB denotes Apparently
T12199 21435-21436 , denotes ,
T12200 21437-21440 DT denotes the
T12201 21441-21450 JJ denotes migratory
T12202 21451-21459 NN denotes behavior
T12203 21460-21462 IN denotes of
T12204 21463-21476 JJ denotes WWOX-negative
T12205 21477-21483 NN denotes glioma
T12206 21484-21489 NNS denotes cells
T12207 21490-21493 MD denotes may
T12208 21494-21501 VB denotes account
T12209 21502-21505 IN denotes for
T12210 21506-21509 DT denotes the
T12211 21510-21517 NN denotes diffuse
T12212 21518-21526 NN denotes invasion
T12213 21527-21531 IN denotes into
T12214 21532-21539 JJ denotes distant
T12215 21540-21545 NN denotes brain
T12216 21546-21552 NN denotes tissue
T12217 21553-21554 -LRB- denotes (
T12218 21554-21558 NNP denotes Chou
T12219 21559-21561 FW denotes et
T12220 21562-21565 FW denotes al.
T12221 21565-21566 , denotes ,
T12222 21567-21578 JJ denotes unpublished
T12223 21578-21579 -RRB- denotes )
T12224 21579-21580 . denotes .
T12225 21581-21590 JJ denotes Metabolic
T12226 21591-21602 NNS denotes alterations
T12227 21603-21607 VBP denotes have
T12228 21608-21612 VBN denotes been
T12229 21613-21618 VBN denotes shown
T12230 21619-21621 IN denotes in
T12231 21622-21626 NNP denotes Wwox
T12232 21627-21635 NN denotes knockout
T12233 21636-21640 NNS denotes mice
T12234 21640-21641 , denotes ,
T12235 21642-21651 VBG denotes including
T12236 21652-21661 JJ denotes postnatal
T12237 21662-21671 NN denotes lethality
T12238 21671-21672 , denotes ,
T12239 21673-21677 NN denotes bone
T12240 21678-21688 NN denotes metabolism
T12241 21689-21696 NNS denotes defects
T12242 21696-21697 , denotes ,
T12243 21698-21704 NN denotes ataxia
T12244 21704-21705 , denotes ,
T12245 21706-21721 NN denotes steroidogenesis
T12246 21721-21722 , denotes ,
T12247 21723-21726 CC denotes and
T12248 21727-21737 NN denotes generation
T12249 21738-21740 IN denotes of
T12250 21741-21754 NNS denotes osteosarcomas
T12251 21755-21756 -LRB- denotes (
T12252 21756-21759 NNP denotes Del
T12253 21760-21764 NNP denotes Mare
T12254 21765-21767 FW denotes et
T12255 21768-21771 FW denotes al.
T12256 21771-21772 , denotes ,
T12257 21773-21777 CD denotes 2011
T12258 21777-21778 : denotes ;
T12259 21779-21784 NNP denotes Salah
T12260 21785-21787 FW denotes et
T12261 21788-21791 FW denotes al.
T12262 21791-21792 , denotes ,
T12263 21793-21797 CD denotes 2012
T12264 21797-21798 -RRB- denotes )
T12265 21798-21799 . denotes .
T12266 21800-21802 IN denotes In
T12267 21803-21804 DT denotes a
T12268 21805-21815 NNP denotes Drosophila
T12269 21816-21821 NN denotes model
T12270 21821-21822 , denotes ,
T12271 21823-21827 NNP denotes Wwox
T12272 21828-21830 VBZ denotes is
T12273 21831-21836 VBN denotes shown
T12274 21837-21839 TO denotes to
T12275 21840-21851 VB denotes participate
T12276 21852-21854 IN denotes in
T12277 21855-21863 NNS denotes pathways
T12278 21864-21873 VBG denotes involving
T12279 21874-21881 JJ denotes aerobic
T12280 21882-21892 NN denotes metabolism
T12281 21893-21896 CC denotes and
T12282 21897-21906 JJ denotes oxidative
T12283 21907-21913 NN denotes stress
T12284 21914-21917 IN denotes for
T12285 21918-21928 NN denotes generation
T12286 21929-21931 IN denotes of
T12287 21932-21935 NNP denotes ROS
T12288 21936-21937 -LRB- denotes (
T12289 21945-21947 FW denotes et
T12290 21948-21951 FW denotes al.
T12291 21951-21952 , denotes ,
T12292 21953-21957 CD denotes 2011
T12293 21957-21958 -RRB- denotes )
T12294 21958-21959 . denotes .
T12295 21960-21965 IN denotes Under
T12296 21966-21968 NNP denotes UV
T12297 21969-21975 NN denotes stress
T12298 21975-21976 , denotes ,
T12299 21977-21987 JJ denotes functional
T12300 21988-21992 NNP denotes Wwox
T12301 21993-21997 NN denotes gene
T12302 21998-22008 NN denotes expression
T12303 22009-22016 VBZ denotes induces
T12304 22017-22020 NNP denotes ROS
T12305 22021-22031 NN denotes production
T12306 22032-22034 IN denotes in
T12307 22035-22045 NNP denotes Drosophila
T12308 22045-22046 . denotes .
T12309 22047-22053 NNP denotes Cancer
T12310 22054-22059 NNS denotes cells
T12311 22060-22063 VBP denotes are
T12312 22064-22069 VBN denotes known
T12313 22070-22072 TO denotes to
T12314 22073-22079 RB denotes overly
T12315 22080-22087 VB denotes utilize
T12316 22088-22098 NN denotes glycolysis
T12317 22099-22102 IN denotes for
T12318 22103-22109 NN denotes growth
T12319 22110-22119 NN denotes advantage
T12320 22122-22125 DT denotes the
T12321 22126-22135 JJ denotes so-called
T12322 22136-22143 NNP denotes Warburg
T12323 22144-22145 -LRB- denotes (
T12324 22145-22152 NNP denotes Moncada
T12325 22153-22155 FW denotes et
T12326 22156-22159 FW denotes al.
T12327 22159-22160 , denotes ,
T12328 22161-22165 CD denotes 2012
T12329 22165-22166 -RRB- denotes )
T12330 22166-22167 . denotes .
T12331 22168-22179 RB denotes Conceivably
T12332 22179-22180 , denotes ,
T12333 22181-22185 NNP denotes WWOX
T12334 22186-22188 VBZ denotes is
T12335 22189-22195 JJ denotes likely
T12336 22196-22198 TO denotes to
T12337 22199-22207 VB denotes override
T12338 22208-22215 NN denotes glucose
T12339 22216-22227 NN denotes consumption
T12340 22228-22230 IN denotes in
T12341 22231-22237 NN denotes cancer
T12342 22238-22243 NNS denotes cells
T12343 22244-22247 CC denotes and
T12344 22248-22254 NNS denotes exerts
T12345 22255-22265 NN denotes generation
T12346 22266-22268 IN denotes of
T12347 22269-22272 NNP denotes ROS
T12348 22273-22275 TO denotes to
T12349 22276-22280 VB denotes curb
T12350 22281-22284 DT denotes the
T12351 22285-22291 NN denotes cancer
T12352 22292-22296 NN denotes cell
T12353 22297-22303 NN denotes growth
T12354 22304-22307 CC denotes and
T12355 22308-22316 NN denotes invasion
T12356 22316-22317 . denotes .
T12357 22318-22320 IN denotes In
T12358 22321-22328 NN denotes summary
T12359 22328-22329 , denotes ,
T12360 22330-22332 IN denotes in
T12361 22333-22337 DT denotes this
T12362 22338-22349 NN denotes perspective
T12363 22350-22357 NN denotes article
T12364 22358-22360 PRP denotes we
T12365 22361-22365 VBP denotes have
T12366 22366-22375 VBN denotes discussed
T12367 22376-22379 DT denotes the
T12368 22380-22389 JJ denotes potential
T12369 22390-22394 NN denotes role
T12370 22395-22397 IN denotes of
T12371 22398-22403 NN denotes tumor
T12372 22404-22415 NNS denotes suppressors
T12373 22416-22419 NN denotes p53
T12374 22420-22423 CC denotes and
T12375 22424-22428 NNP denotes WWOX
T12376 22429-22431 IN denotes in
T12377 22432-22442 VBG denotes regulating
T12378 22443-22446 NNP denotes TMZ
T12379 22447-22458 NN denotes sensitivity
T12380 22459-22461 IN denotes in
T12381 22462-22465 NNP denotes GBM
T12382 22466-22471 NNS denotes cells
T12383 22471-22472 . denotes .
T12384 22473-22475 PRP denotes We
T12385 22476-22480 VBP denotes have
T12386 22481-22486 VBN denotes shown
T12387 22487-22490 DT denotes the
T12388 22491-22495 NN denotes role
T12389 22496-22498 IN denotes of
T12390 22499-22503 NNP denotes WWOX
T12391 22504-22506 IN denotes in
T12392 22507-22518 VBG denotes controlling
T12393 22519-22523 NN denotes cell
T12394 22524-22533 NN denotes migration
T12395 22534-22537 CC denotes and
T12396 22538-22547 JJ denotes metabolic
T12397 22548-22559 NNS denotes alterations
T12398 22559-22560 , denotes ,
T12399 22561-22564 CC denotes and
T12400 22565-22574 VBD denotes discussed
T12401 22575-22578 DT denotes the
T12402 22579-22586 NNS denotes effects
T12403 22587-22589 IN denotes of
T12404 22590-22594 NNP denotes WWOX
T12405 22595-22605 NN denotes deficiency
T12406 22606-22609 CC denotes and
T12407 22610-22613 NNP denotes TMZ
T12408 22614-22624 NN denotes resistance
T12409 22625-22627 IN denotes in
T12410 22628-22634 NN denotes cancer
T12411 22635-22640 NNS denotes cells
T12412 22640-22641 . denotes .
T12540 22664-22671 NNP denotes Ming-Fu
T12541 22672-22678 NNP denotes Chiang
T12542 22679-22682 CC denotes and
T12543 22683-22689 NNP denotes Chun-I
T12544 22690-22693 NNP denotes Sze
T12545 22694-22699 VBD denotes wrote
T12546 22700-22703 DT denotes the
T12547 22704-22712 NNS denotes sections
T12548 22713-22720 VBG denotes dealing
T12549 22721-22725 IN denotes with
T12550 22726-22729 NNP denotes TMZ
T12551 22729-22730 : denotes ;
T12552 22731-22737 NNP denotes Pei-Yi
T12553 22738-22742 NNP denotes Chou
T12554 22743-22748 VBD denotes wrote
T12555 22749-22752 DT denotes the
T12556 22753-22759 NN denotes review
T12557 22760-22768 NNS denotes sections
T12558 22769-22772 IN denotes for
T12559 22773-22776 NN denotes p53
T12560 22777-22780 CC denotes and
T12561 22781-22785 NNP denotes WWOX
T12562 22786-22789 CC denotes and
T12563 22790-22798 VBN denotes designed
T12564 22799-22805 NNS denotes graphs
T12565 22805-22806 : denotes ;
T12566 22807-22814 NNP denotes Wan-Jen
T12567 22815-22819 NNP denotes Wang
T12568 22820-22827 VBD denotes managed
T12569 22828-22837 NNS denotes citations
T12570 22837-22838 : denotes ;
T12571 22839-22847 NNP denotes Nan-Shan
T12572 22848-22853 NNP denotes Chang
T12573 22854-22863 VBD denotes conceived
T12574 22864-22869 NNS denotes ideas
T12575 22869-22870 , denotes ,
T12576 22871-22876 VBD denotes wrote
T12577 22877-22880 CC denotes and
T12578 22881-22891 RB denotes thoroughly
T12579 22892-22899 VBD denotes revised
T12580 22900-22903 DT denotes the
T12581 22904-22914 NN denotes manuscript
T12582 22914-22915 , denotes ,
T12583 22916-22919 CC denotes and
T12584 22920-22929 VBN denotes discussed
T12585 22930-22934 IN denotes with
T12586 22935-22944 NNS denotes coauthors
T12587 22944-22945 . denotes .
T12618 22978-22981 DT denotes The
T12619 22982-22989 NNS denotes authors
T12620 22990-22997 VBP denotes declare
T12621 22998-23002 IN denotes that
T12622 23003-23006 DT denotes the
T12623 23007-23015 NN denotes research
T12624 23016-23019 VBD denotes was
T12625 23020-23029 VBN denotes conducted
T12626 23030-23032 IN denotes in
T12627 23033-23036 DT denotes the
T12628 23037-23044 NN denotes absence
T12629 23045-23047 IN denotes of
T12630 23048-23051 DT denotes any
T12631 23052-23062 JJ denotes commercial
T12632 23063-23065 CC denotes or
T12633 23066-23075 JJ denotes financial
T12634 23076-23089 NNS denotes relationships
T12635 23090-23094 WDT denotes that
T12636 23095-23100 MD denotes could
T12637 23101-23103 VB denotes be
T12638 23104-23113 VBN denotes construed
T12639 23114-23116 IN denotes as
T12640 23117-23118 DT denotes a
T12641 23119-23128 JJ denotes potential
T12642 23129-23137 NN denotes conflict
T12643 23138-23140 IN denotes of
T12644 23141-23149 NN denotes interest
T12645 23149-23150 . denotes .
R10000 T14574 T14576 amod N-terminal,mutants
R10001 T14575 T14576 compound deletion,mutants
R10002 T14576 T14581 nsubjpass mutants,shown
R10003 T14577 T14576 prep of,mutants
R10004 T14578 T14577 pobj p53,of
R10005 T14579 T14581 auxpass are,shown
R10006 T14580 T14581 advmod also,shown
R10007 T14581 T14581 ROOT shown,shown
R10008 T14582 T14581 punct .,shown
R10009 T14583 T14584 punct (,B
R10010 T14584 T14584 ROOT B,B
R10011 T14585 T14584 punct ),B
R10012 T14586 T14588 nummod Three,scenarios
R10013 T14587 T14588 amod likely,scenarios
R10014 T14588 T14590 nsubjpass scenarios,proposed
R10015 T14589 T14590 auxpass are,proposed
R10016 T14590 T14590 ROOT proposed,proposed
R10017 T14591 T14590 prep for,proposed
R10018 T14592 T14591 pobj WWOX,for
R10019 T14593 T14592 cc and,WWOX
R10020 T14594 T14592 conj p53,WWOX
R10021 T14595 T14596 aux to,regulate
R10022 T14596 T14590 advcl regulate,proposed
R10023 T14597 T14599 compound GBM,death
R10024 T14598 T14599 compound cell,death
R10025 T14599 T14596 dobj death,regulate
R10026 T14600 T14590 punct .,proposed
R10027 T14601 T14605 advmod First,fails
R10028 T14602 T14605 punct ",",fails
R10029 T14603 T14604 compound ectopic,WWOX
R10030 T14604 T14605 nsubj WWOX,fails
R10031 T14605 T14605 ROOT fails,fails
R10032 T14606 T14607 aux to,induce
R10033 T14607 T14605 xcomp induce,fails
R10034 T14608 T14607 dobj apoptosis,induce
R10035 T14609 T14608 prep of,apoptosis
R10036 T14610 T14611 compound GBM,cells
R10037 T14611 T14609 pobj cells,of
R10038 T14612 T14611 acl expressing,cells
R10039 T14613 T14616 amod endogenous,p53
R10040 T14614 T14615 amod wild,type
R10041 T14615 T14616 compound type,p53
R10042 T14616 T14612 dobj p53,expressing
R10043 T14617 T14605 punct .,fails
R10044 T14618 T14619 nsubj It,appears
R10045 T14619 T14619 ROOT appears,appears
R10046 T14620 T14623 mark that,binds
R10047 T14621 T14622 compound ectopic,WWOX
R10048 T14622 T14623 compound WWOX,binds
R10049 T14623 T14632 nsubj binds,nullify
R10050 T14624 T14623 cc and,binds
R10051 T14625 T14626 advmod functionally,antagonizes
R10052 T14626 T14623 conj antagonizes,binds
R10053 T14627 T14626 dobj p53,antagonizes
R10054 T14628 T14626 punct ",",antagonizes
R10055 T14629 T14626 cc and,antagonizes
R10056 T14630 T14631 det both,proteins
R10057 T14631 T14626 conj proteins,antagonizes
R10058 T14632 T14619 ccomp nullify,appears
R10059 T14633 T14634 det each,other
R10060 T14634 T14635 poss other,function
R10061 T14635 T14632 dobj function,nullify
R10062 T14636 T14632 prep in,nullify
R10063 T14637 T14636 pcomp inducing,in
R10064 T14638 T14637 dobj apoptosis,inducing
R10065 T14639 T14619 punct .,appears
R10066 T14640 T14652 advmod Second,expected
R10067 T14641 T14652 punct ",",expected
R10068 T14642 T14644 det no,interactions
R10069 T14643 T14644 amod physical,interactions
R10070 T14644 T14652 nsubjpass interactions,expected
R10071 T14645 T14644 prep between,interactions
R10072 T14646 T14648 amod mutant,proteins
R10073 T14647 T14648 compound p53,proteins
R10074 T14648 T14645 pobj proteins,between
R10075 T14649 T14648 cc and,proteins
R10076 T14650 T14648 conj WWOX,proteins
R10077 T14651 T14652 auxpass are,expected
R10078 T14652 T14652 ROOT expected,expected
R10079 T14653 T14652 prep in,expected
R10080 T14654 T14655 compound GBM,cells
R10081 T14655 T14653 pobj cells,in
R10082 T14656 T14652 punct .,expected
R10083 T14657 T14661 advmod Thus,induce
R10084 T14658 T14661 punct ",",induce
R10085 T14659 T14661 nsubj ectopic,induce
R10086 T14660 T14661 nsubj WWOX,induce
R10087 T14661 T14661 ROOT induce,induce
R10088 T14662 T14661 dobj apoptosis,induce
R10089 T14663 T14662 prep in,apoptosis
R10090 T14664 T14666 amod mutant,cells
R10091 T14665 T14666 amod p53-expressing,cells
R10092 T14666 T14663 pobj cells,in
R10093 T14667 T14661 punct .,induce
R10094 T14668 T14675 advmod Finally,is
R10095 T14669 T14675 punct ",",is
R10096 T14670 T14672 mark whether,binds
R10097 T14671 T14672 nsubj WWOX,binds
R10098 T14672 T14675 csubj binds,is
R10099 T14673 T14674 compound p53,isoforms
R10100 T14674 T14672 dobj isoforms,binds
R10101 T14675 T14675 ROOT is,is
R10102 T14676 T14675 acomp unknown,is
R10103 T14677 T14675 punct .,is
R10104 T14678 T14692 advmod Also,remains
R10105 T14679 T14692 punct ",",remains
R10106 T14680 T14692 mark whether,remains
R10107 T14681 T14683 amod ectopic,induction
R10108 T14682 T14683 compound WWOX,induction
R10109 T14683 T14692 nsubj induction,remains
R10110 T14684 T14683 prep of,induction
R10111 T14685 T14684 pobj apoptosis,of
R10112 T14686 T14683 prep in,induction
R10113 T14687 T14688 compound GBM,cells
R10114 T14688 T14686 pobj cells,in
R10115 T14689 T14692 csubj expressing,remains
R10116 T14690 T14691 compound p53,isoforms
R10117 T14691 T14689 dobj isoforms,expressing
R10118 T14692 T14692 ROOT remains,remains
R10119 T14693 T14695 aux to,established
R10120 T14694 T14695 auxpass be,established
R10121 T14695 T14692 xcomp established,remains
R10122 T14696 T14692 punct .,remains
R10123 T14697 T14700 nmod TAD,domain
R10124 T14698 T14700 punct ",",domain
R10125 T14699 T14700 amod transactivation,domain
R10126 T14700 T14700 ROOT domain,domain
R10127 T14701 T14700 punct ;,domain
R10128 T14702 T14705 nmod PrD,domain
R10129 T14703 T14705 punct ",",domain
R10130 T14704 T14705 compound proline,domain
R10131 T14705 T14700 appos domain,domain
R10132 T14706 T14700 punct ;,domain
R10133 T14707 T14711 nmod NLS,signal
R10134 T14708 T14707 punct ",",NLS
R10135 T14709 T14710 amod nuclear,localization
R10136 T14710 T14711 compound localization,signal
R10137 T14711 T14711 ROOT signal,signal
R10138 T14712 T14711 punct ;,signal
R10139 T14713 T14716 nmod OD,domain
R10140 T14714 T14716 punct ",",domain
R10141 T14715 T14716 amod oligomerization,domain
R10142 T14716 T14700 conj domain,domain
R10143 T14717 T14716 punct ;,domain
R10144 T14718 T14721 nmod BR,region
R10145 T14719 T14721 punct ",",region
R10146 T14720 T14721 amod basic,region
R10147 T14721 T14716 npadvmod region,domain
R10148 T14722 T14700 punct .,domain
R1576 T2518 T2516 npadvmod 2000,al.
R1577 T2519 T2516 punct ;,al.
R1578 T2520 T2522 compound Stupp,al.
R1579 T2521 T2522 compound et,al.
R1580 T2503 T2504 compound Glioblastoma,multiforme
R1581 T2522 T2505 prep al.,afflicts
R1582 T2504 T2505 nsubj multiforme,afflicts
R1583 T2505 T2528 ccomp afflicts,al.
R1584 T2523 T2522 punct ",",al.
R1585 T2506 T2508 nummod "12,500",patients
R1586 T2524 T2522 npadvmod 2009,al.
R1587 T2507 T2508 amod new,patients
R1588 T2508 T2505 dobj patients,afflicts
R1589 T2509 T2508 prep in,patients
R1590 T2510 T2511 det the,U.S.
R1591 T2525 T2528 punct ;,al.
R1592 T2511 T2509 pobj U.S.,in
R1593 T2512 T2505 advmod annually,afflicts
R1594 T2526 T2528 compound Silber,al.
R1595 T2527 T2528 compound et,al.
R1596 T2528 T2528 ROOT al.,al.
R1597 T2513 T2516 punct (,al.
R1598 T2529 T2528 punct ",",al.
R1599 T2514 T2516 nmod Friedman,al.
R1600 T2515 T2516 nmod et,al.
R1601 T2530 T2528 npadvmod 2012,al.
R1602 T2516 T2522 compound al.,al.
R1603 T2517 T2516 punct ",",al.
R1604 T2531 T2528 punct ),al.
R1605 T2532 T2528 punct .,al.
R1606 T2533 T2537 nsubj Glioblastoma,is
R1607 T2534 T2535 punct (,GBM
R1608 T2570 T2571 compound et,al.
R1609 T2571 T2558 attr al.,is
R1610 T2535 T2533 appos GBM,Glioblastoma
R1611 T2572 T2571 punct ",",al.
R1612 T2573 T2571 npadvmod 2009,al.
R1613 T2574 T2558 punct ),is
R1614 T2536 T2533 punct ),Glioblastoma
R1615 T2575 T2546 punct .,is
R1616 T2576 T2577 amod High,levels
R1617 T2537 T2537 ROOT is,is
R1618 T2577 T2589 nsubjpass levels,seen
R1619 T2578 T2577 prep of,levels
R1620 T2579 T2578 pobj resistance,of
R1621 T2538 T2539 advmod highly,lethal
R1622 T2580 T2579 prep to,resistance
R1623 T2581 T2583 amod current,modalities
R1624 T2582 T2583 amod therapeutic,modalities
R1625 T2539 T2537 acomp lethal,is
R1626 T2583 T2580 pobj modalities,to
R1627 T2584 T2583 cc and,modalities
R1628 T2585 T2586 compound cancer,relapse
R1629 T2586 T2583 conj relapse,modalities
R1630 T2540 T2537 punct ",",is
R1631 T2587 T2589 auxpass are,seen
R1632 T2588 T2589 advmod frequently,seen
R1633 T2541 T2537 cc and,is
R1634 T2589 T2601 ccomp seen,al.
R1635 T2542 T2545 det the,expectancy
R1636 T2590 T2589 prep in,seen
R1637 T2543 T2545 amod average,expectancy
R1638 T2591 T2590 pobj patients,in
R1639 T2544 T2545 compound survival,expectancy
R1640 T2545 T2546 nsubj expectancy,is
R1641 T2592 T2595 punct (,al.
R1642 T2546 T2537 conj is,is
R1643 T2593 T2595 nmod Haar,al.
R1644 T2594 T2595 nmod et,al.
R1645 T2595 T2601 dep al.,al.
R1646 T2547 T2548 nummod 14.6,months
R1647 T2596 T2595 punct ",",al.
R1648 T2597 T2595 npadvmod 2012,al.
R1649 T2548 T2546 attr months,is
R1650 T2598 T2601 punct ;,al.
R1651 T2599 T2601 compound Happold,al.
R1652 T2600 T2601 compound et,al.
R1653 T2549 T2546 punct ",",is
R1654 T2601 T2601 ROOT al.,al.
R1655 T2602 T2601 punct ",",al.
R1656 T2603 T2601 npadvmod 2012,al.
R1657 T2604 T2601 punct ),al.
R1658 T2605 T2601 punct .,al.
R1659 T2606 T2609 det The,therapy
R1660 T2550 T2546 cc and,is
R1661 T2607 T2609 amod current,therapy
R1662 T2608 T2609 amod standard,therapy
R1663 T2609 T2613 nsubj therapy,includes
R1664 T2551 T2555 det the,rate
R1665 T2610 T2609 prep for,therapy
R1666 T2611 T2610 pobj GBM,for
R1667 T2612 T2613 advmod mainly,includes
R1668 T2552 T2555 amod overall,rate
R1669 T2613 T2613 ROOT includes,includes
R1670 T2614 T2616 amod maximum,surgery
R1671 T2615 T2616 compound debulking,surgery
R1672 T2553 T2555 amod 5-year,rate
R1673 T2616 T2613 dobj surgery,includes
R1674 T2617 T2616 punct ",",surgery
R1675 T2618 T2616 conj radiation,surgery
R1676 T2554 T2555 compound survival,rate
R1677 T2619 T2618 punct ",",radiation
R1678 T2620 T2618 cc and,radiation
R1679 T2555 T2558 nsubj rate,is
R1680 T2621 T2618 conj treatment,radiation
R1681 T2622 T2616 prep with,surgery
R1682 T2623 T2626 det the,agent
R1683 T2624 T2626 amod monofunctional,agent
R1684 T2556 T2555 prep for,rate
R1685 T2625 T2626 amod alkylating,agent
R1686 T2626 T2627 compound agent,temozolomide
R1687 T2627 T2622 pobj temozolomide,with
R1688 T2557 T2556 pobj GBM,for
R1689 T2628 T2627 punct (,temozolomide
R1690 T2629 T2627 appos TMZ,temozolomide
R1691 T2558 T2546 conj is,is
R1692 T2630 T2627 punct ),temozolomide
R1693 T2631 T2634 punct (,al.
R1694 T2632 T2634 compound Friedman,al.
R1695 T2559 T2560 advmod only,9.8
R1696 T2633 T2634 nmod et,al.
R1697 T2634 T2638 compound al.,Nishikawa
R1698 T2560 T2561 nummod 9.8,%
R1699 T2635 T2634 punct ",",al.
R1700 T2636 T2634 dep 2000,al.
R1701 T2637 T2634 punct ;,al.
R1702 T2561 T2558 attr %,is
R1703 T2638 T2616 appos Nishikawa,surgery
R1704 T2639 T2638 punct ",",Nishikawa
R1705 T2640 T2638 npadvmod 2010,Nishikawa
R1706 T2641 T2638 punct ),Nishikawa
R1707 T2642 T2613 punct .,includes
R1708 T2643 T2644 amod Multiple,mechanisms
R1709 T2562 T2565 punct (,al.
R1710 T2644 T2646 nsubjpass mechanisms,involved
R1711 T2645 T2646 auxpass are,involved
R1712 T2646 T2718 ccomp involved,al.
R1713 T2647 T2646 prep in,involved
R1714 T2563 T2565 compound Friedman,al.
R1715 T2648 T2650 det the,resistance
R1716 T2649 T2650 compound TMZ,resistance
R1717 T2650 T2647 pobj resistance,in
R1718 T2564 T2565 nmod et,al.
R1719 T2651 T2650 punct ",",resistance
R1720 T2652 T2654 nsubj which,include
R1721 T2653 T2654 aux may,include
R1722 T2565 T2558 parataxis al.,is
R1723 T2654 T2650 relcl include,resistance
R1724 T2655 T2657 compound cancer,cells
R1725 T2656 T2657 compound stem,cells
R1726 T2566 T2565 punct ",",al.
R1727 T2657 T2654 dobj cells,include
R1728 T2658 T2657 punct ",",cells
R1729 T2659 T2657 conj microRNAs,cells
R1730 T2567 T2565 npadvmod 2000,al.
R1731 T2660 T2659 punct ",",microRNAs
R1732 T2661 T2662 compound drug,efflux
R1733 T2662 T2659 conj efflux,microRNAs
R1734 T2663 T2662 punct ",",efflux
R1735 T2568 T2558 punct ;,is
R1736 T2664 T2666 compound DNA,repair
R1737 T2665 T2666 compound damage,repair
R1738 T2666 T2662 conj repair,efflux
R1739 T2569 T2571 compound Stupp,al.
R1740 T2764 T2765 aux to,cause
R1741 T2667 T2666 punct ",",repair
R1742 T2668 T2669 compound tumor,cells
R1743 T2765 T2757 advcl cause,trigger
R1744 T2669 T2659 conj cells,microRNAs
R1745 T2766 T2767 compound cell,death
R1746 T2670 T2654 prep under,include
R1747 T2767 T2765 dobj death,cause
R1748 T2671 T2670 pobj hypoxia,under
R1749 T2768 T2765 punct (,cause
R1750 T2769 T2771 compound Kanzawa,al.
R1751 T2672 T2671 punct ",",hypoxia
R1752 T2770 T2771 nmod et,al.
R1753 T2673 T2674 compound histone,deacetylation
R1754 T2674 T2671 appos deacetylation,hypoxia
R1755 T2675 T2674 punct ",",deacetylation
R1756 T2676 T2677 amod epithelial-mesenchymal,transition
R1757 T2677 T2674 appos transition,deacetylation
R1758 T2678 T2677 punct ",",transition
R1759 T2679 T2680 nummod STAT3,kinase
R1760 T2771 T2765 advmod al.,cause
R1761 T2680 T2677 conj kinase,transition
R1762 T2681 T2680 punct ",",kinase
R1763 T2772 T2771 punct ",",al.
R1764 T2682 T2680 cc and,kinase
R1765 T2683 T2684 amod many,others
R1766 T2684 T2680 conj others,kinase
R1767 T2773 T2771 npadvmod 2003,al.
R1768 T2685 T2684 punct (,others
R1769 T2686 T2688 compound Haar,al.
R1770 T2687 T2688 nmod et,al.
R1771 T2774 T2771 punct ),al.
R1772 T2688 T2684 appos al.,others
R1773 T2689 T2688 punct ",",al.
R1774 T2775 T2755 punct .,known
R1775 T2690 T2688 npadvmod 2012,al.
R1776 T2691 T2684 punct ;,others
R1777 T2692 T2694 compound Happold,al.
R1778 T2776 T2791 advmod Also,leads
R1779 T2693 T2694 compound et,al.
R1780 T2694 T2684 conj al.,others
R1781 T2695 T2694 punct ",",al.
R1782 T2777 T2791 punct ",",leads
R1783 T2696 T2694 npadvmod 2012,al.
R1784 T2697 T2718 punct ;,al.
R1785 T2698 T2718 dep Johannessen,al.
R1786 T2778 T2791 nsubj inhibition,leads
R1787 T2699 T2698 cc and,Johannessen
R1788 T2700 T2698 conj Bjerkvig,Johannessen
R1789 T2701 T2700 punct ",",Bjerkvig
R1790 T2702 T2700 npadvmod 2012,Bjerkvig
R1791 T2779 T2778 prep of,inhibition
R1792 T2703 T2700 punct ;,Bjerkvig
R1793 T2704 T2706 compound Kitange,al.
R1794 T2705 T2706 compound et,al.
R1795 T2780 T2781 amod antiapoptotic,Bcl-2
R1796 T2706 T2700 conj al.,Bjerkvig
R1797 T2707 T2706 punct ",",al.
R1798 T2708 T2706 npadvmod 2012,al.
R1799 T2781 T2779 pobj Bcl-2,of
R1800 T2709 T2718 punct ;,al.
R1801 T2710 T2712 compound Kohsaka,al.
R1802 T2711 T2712 compound et,al.
R1803 T2782 T2778 prep by,inhibition
R1804 T2712 T2718 ccomp al.,al.
R1805 T2713 T2712 punct ",",al.
R1806 T2714 T2712 npadvmod 2012,al.
R1807 T2715 T2718 punct ;,al.
R1808 T2716 T2718 compound Zhang,al.
R1809 T2717 T2718 nmod et,al.
R1810 T2783 T2785 det a,inhibitor
R1811 T2718 T2718 ROOT al.,al.
R1812 T2719 T2720 punct ",",2012b
R1813 T2784 T2785 compound pan-Bcl-2,inhibitor
R1814 T2720 T2718 amod 2012b,al.
R1815 T2785 T2782 pobj inhibitor,by
R1816 T2721 T2720 punct ),2012b
R1817 T2722 T2718 punct .,al.
R1818 T2723 T2724 nsubj Temozolomide,induces
R1819 T2786 T2787 punct (,−
R1820 T2724 T2746 ccomp induces,al.
R1821 T2725 T2724 dobj generation,induces
R1822 T2787 T2785 appos −,inhibitor
R1823 T2726 T2725 prep of,generation
R1824 T2727 T2728 compound DNA,lesions
R1825 T2728 T2726 pobj lesions,of
R1826 T2729 T2728 punct ",",lesions
R1827 T2788 T2787 punct ),−
R1828 T2730 T2728 prep including,lesions
R1829 T2731 T2730 pobj O6-methylguanine,including
R1830 T2789 T2791 punct -,leads
R1831 T2732 T2731 punct ",",O6-methylguanine
R1832 T2733 T2731 conj N3-methyladenine,O6-methylguanine
R1833 T2734 T2733 punct ",",N3-methyladenine
R1834 T2790 T2791 nsubj gossypol,leads
R1835 T2735 T2733 cc and,N3-methyladenine
R1836 T2736 T2733 conj N7-methylguanine,N3-methyladenine
R1837 T2737 T2740 punct (,al.
R1838 T2791 T2791 ROOT leads,leads
R1839 T2738 T2740 compound Goellner,al.
R1840 T2739 T2740 nmod et,al.
R1841 T2740 T2731 appos al.,O6-methylguanine
R1842 T2792 T2791 prep to,leads
R1843 T2741 T2740 punct ",",al.
R1844 T2742 T2740 npadvmod 2011,al.
R1845 T2793 T2792 pobj autophagic,to
R1846 T2743 T2746 punct ;,al.
R1847 T2744 T2746 compound Zhang,al.
R1848 T2745 T2746 compound et,al.
R1849 T2794 T2793 dobj death,autophagic
R1850 T2746 T2746 ROOT al.,al.
R1851 T2747 T2748 punct ",",2012b
R1852 T2795 T2793 prep in,autophagic
R1853 T2748 T2746 amod 2012b,al.
R1854 T2796 T2795 pobj gliomas,in
R1855 T2749 T2748 punct ),2012b
R1856 T2750 T2746 punct .,al.
R1857 T2751 T2753 det The,lesion
R1858 T2752 T2753 amod O6-methylguanine,lesion
R1859 T2797 T2791 cc and,leads
R1860 T2753 T2755 nsubjpass lesion,known
R1861 T2754 T2755 auxpass is,known
R1862 T2755 T2755 ROOT known,known
R1863 T2798 T2791 conj enhances,leads
R1864 T2756 T2757 aux to,trigger
R1865 T2757 T2755 xcomp trigger,known
R1866 T2758 T2757 dobj autophagy,trigger
R1867 T2759 T2758 punct ",",autophagy
R1868 T2760 T2761 advmod rather,than
R1869 T2799 T2800 det the,action
R1870 T2761 T2757 prep than,trigger
R1871 T2762 T2761 pobj apoptosis,than
R1872 T2763 T2757 punct ",",trigger
R1873 T2800 T2798 dobj action,enhances
R1874 T2801 T2800 prep of,action
R1875 T2802 T2801 pobj TMZ,of
R1876 T2803 T2806 punct (,al.
R1877 T2861 T2863 dep MAPO2,encodes
R1878 T2862 T2863 nsubj gene,encodes
R1879 T2804 T2806 compound Voss,al.
R1880 T2863 T2863 ROOT encodes,encodes
R1881 T2864 T2867 det a,protein
R1882 T2865 T2867 compound novel,protein
R1883 T2805 T2806 nmod et,al.
R1884 T2866 T2867 compound 37-kDa,protein
R1885 T2867 T2863 dobj protein,encodes
R1886 T2806 T2800 appos al.,action
R1887 T2868 T2863 punct .,encodes
R1888 T2869 T2872 nsubjpass It,determined
R1889 T2870 T2872 auxpass is,determined
R1890 T2871 T2872 neg not,determined
R1891 T2807 T2806 punct ",",al.
R1892 T2872 T2872 ROOT determined,determined
R1893 T2873 T2876 mark whether,is
R1894 T2874 T2875 det this,gene
R1895 T2808 T2806 npadvmod 2010,al.
R1896 T2875 T2876 nsubj gene,is
R1897 T2809 T2798 punct ),enhances
R1898 T2810 T2791 punct .,leads
R1899 T2876 T2877 auxpass is,involved
R1900 T2877 T2872 xcomp involved,determined
R1901 T2811 T2816 advmod However,demonstrated
R1902 T2878 T2877 prep in,involved
R1903 T2879 T2878 pobj autophagy,in
R1904 T2812 T2816 punct ",",demonstrated
R1905 T2880 T2872 punct .,determined
R1906 T2881 T2883 det The,lesion
R1907 T2882 T2883 amod O6-methylguanine,lesion
R1908 T2883 T2884 nsubj lesion,is
R1909 T2884 T2884 ROOT is,is
R1910 T2885 T2886 det a,substrate
R1911 T2813 T2815 det a,study
R1912 T2886 T2884 attr substrate,is
R1913 T2887 T2886 prep for,substrate
R1914 T2888 T2889 amod direct,repair
R1915 T2814 T2815 amod recent,study
R1916 T2889 T2887 pobj repair,for
R1917 T2815 T2816 nsubj study,demonstrated
R1918 T2816 T2816 ROOT demonstrated,demonstrated
R1919 T2890 T2889 prep by,repair
R1920 T2817 T2820 mark that,is
R1921 T2891 T2892 compound O6-methylguanine-DNA,methyltransferase
R1922 T2892 T2890 pobj methyltransferase,by
R1923 T2893 T2894 punct (,MGMT
R1924 T2818 T2819 amod TMZ-induced,autophagy
R1925 T2894 T2892 appos MGMT,methyltransferase
R1926 T2895 T2884 punct ),is
R1927 T2819 T2820 nsubj autophagy,is
R1928 T2896 T2899 punct (,al.
R1929 T2897 T2899 compound Pollack,al.
R1930 T2898 T2899 nmod et,al.
R1931 T2820 T2816 ccomp is,demonstrated
R1932 T2899 T2905 compound al.,al.
R1933 T2900 T2899 punct ",",al.
R1934 T2901 T2899 npadvmod 2006,al.
R1935 T2821 T2820 acomp pro-survival,is
R1936 T2902 T2899 punct ;,al.
R1937 T2903 T2905 compound Hegi,al.
R1938 T2904 T2905 compound et,al.
R1939 T2822 T2820 punct ",",is
R1940 T2905 T2905 ROOT al.,al.
R1941 T2906 T2905 punct ",",al.
R1942 T2823 T2820 cc and,is
R1943 T2824 T2825 aux may,block
R1944 T2907 T2905 npadvmod 2008,al.
R1945 T2908 T2905 punct ;,al.
R1946 T2825 T2820 conj block,is
R1947 T2909 T2911 compound Fukushima,al.
R1948 T2910 T2911 nmod et,al.
R1949 T2911 T2905 conj al.,al.
R1950 T2826 T2828 det the,apoptosis
R1951 T2912 T2911 punct ",",al.
R1952 T2913 T2911 npadvmod 2009,al.
R1953 T2827 T2828 amod eventual,apoptosis
R1954 T2914 T2917 punct ;,al.
R1955 T2915 T2917 compound Zhang,al.
R1956 T2916 T2917 nmod et,al.
R1957 T2917 T2884 attr al.,is
R1958 T2918 T2919 punct ",",2012b
R1959 T2828 T2825 dobj apoptosis,block
R1960 T2919 T2917 amod 2012b,al.
R1961 T2920 T2919 punct ),2012b
R1962 T2921 T2884 punct .,is
R1963 T2922 T2927 prep Without,initiates
R1964 T2923 T2924 compound MGMT,repair
R1965 T2829 T2825 prep in,block
R1966 T2924 T2922 pobj repair,Without
R1967 T2925 T2927 punct ",",initiates
R1968 T2926 T2927 nsubj O6-methylguanine,initiates
R1969 T2927 T2927 ROOT initiates,initiates
R1970 T2830 T2831 compound GBM,cells
R1971 T2928 T2927 dobj activation,initiates
R1972 T2929 T2928 prep of,activation
R1973 T2930 T2929 pobj mismatch,of
R1974 T2931 T2928 conj repair-deficient,activation
R1975 T2831 T2829 pobj cells,in
R1976 T2932 T2931 punct (,repair-deficient
R1977 T2933 T2935 nmod MMR,proteins
R1978 T2934 T2935 punct ),proteins
R1979 T2935 T2931 appos proteins,repair-deficient
R1980 T2832 T2835 punct (,al.
R1981 T2936 T2935 cc or,proteins
R1982 T2937 T2939 amod Rad3-related,kinase
R1983 T2833 T2835 compound Knizhnik,al.
R1984 T2938 T2939 compound protein,kinase
R1985 T2939 T2935 conj kinase,proteins
R1986 T2940 T2942 nsubj that,leads
R1987 T2834 T2835 nmod et,al.
R1988 T2941 T2942 advmod ultimately,leads
R1989 T2942 T2939 relcl leads,kinase
R1990 T2943 T2942 prep to,leads
R1991 T2835 T2825 parataxis al.,block
R1992 T2944 T2946 amod apoptotic,death
R1993 T2945 T2946 compound cell,death
R1994 T2946 T2943 pobj death,to
R1995 T2836 T2835 punct ",",al.
R1996 T2947 T2950 punct (,al.
R1997 T2948 T2950 compound Caporali,al.
R1998 T2949 T2950 nmod et,al.
R1999 T2837 T2835 npadvmod 2013,al.
R2000 T2950 T2939 appos al.,kinase
R2001 T2951 T2950 punct ",",al.
R2002 T2952 T2950 npadvmod 2004,al.
R2003 T2838 T2835 punct ),al.
R2004 T2953 T2927 punct ;,initiates
R2005 T2839 T2816 punct .,demonstrated
R2006 T2954 T2927 conj Wang,initiates
R2007 T2955 T2954 cc and,Wang
R2008 T2956 T2954 conj Edelmann,Wang
R2009 T2957 T2956 punct ",",Edelmann
R2010 T2840 T2847 advmod Also,participates
R2011 T2841 T2847 punct ",",participates
R2012 T2842 T2847 nsubj MAPO2,participates
R2013 T2958 T2954 npadvmod 2006,Wang
R2014 T2959 T2954 punct ;,Wang
R2015 T2843 T2842 punct (,MAPO2
R2016 T2960 T2962 compound Roos,al.
R2017 T2961 T2962 nmod et,al.
R2018 T2844 T2842 appos C1orf201,MAPO2
R2019 T2962 T2954 conj al.,Wang
R2020 T2963 T2962 punct ",",al.
R2021 T2964 T2962 npadvmod 2007,al.
R2022 T2845 T2842 punct ),MAPO2
R2023 T2965 T2962 punct ),al.
R2024 T2966 T2927 punct .,initiates
R2025 T2967 T2968 compound High,expression
R2026 T2968 T2975 nsubj expression,contributes
R2027 T2846 T2847 nsubj gene,participates
R2028 T2969 T2968 prep of,expression
R2029 T2970 T2969 pobj MGMT,of
R2030 T2971 T2970 cc or,MGMT
R2031 T2847 T2847 ROOT participates,participates
R2032 T2972 T2968 conj loss,expression
R2033 T2973 T2972 prep of,loss
R2034 T2974 T2973 pobj MMR,of
R2035 T2848 T2847 prep in,participates
R2036 T2975 T2999 ccomp contributes,al.
R2037 T2976 T2975 advmod significantly,contributes
R2038 T2977 T2975 prep to,contributes
R2039 T2849 T2852 det the,apoptosis
R2040 T2978 T2979 compound TMZ,resistance
R2041 T2979 T2977 pobj resistance,to
R2042 T2980 T2975 prep in,contributes
R2043 T2850 T2852 amod O6-methylguanine,apoptosis
R2044 T2981 T2983 amod many,cases
R2045 T2982 T2983 amod clinical,cases
R2046 T2851 T2852 amod lesion-induced,apoptosis
R2047 T2983 T2980 pobj cases,in
R2048 T2984 T2987 punct (,al.
R2049 T2985 T2987 compound Pollack,al.
R2050 T2852 T2848 pobj apoptosis,in
R2051 T2986 T2987 nmod et,al.
R2052 T2853 T2856 punct (,al.
R2053 T2854 T2856 nmod Fujikane,al.
R2054 T2987 T2975 advcl al.,contributes
R2055 T2988 T2987 punct ",",al.
R2056 T2855 T2856 nmod et,al.
R2057 T2989 T2987 npadvmod 2006,al.
R2058 T2990 T2999 punct ;,al.
R2059 T2991 T2993 compound Hegi,al.
R2060 T2992 T2993 nmod et,al.
R2061 T2856 T2852 appos al.,apoptosis
R2062 T2993 T2999 ccomp al.,al.
R2063 T2994 T2993 punct ",",al.
R2064 T2857 T2856 punct ",",al.
R2065 T2995 T2993 npadvmod 2008,al.
R2066 T2858 T2856 npadvmod 2012,al.
R2067 T2996 T2999 punct ;,al.
R2068 T2997 T2999 compound Sarkaria,al.
R2069 T2998 T2999 nmod et,al.
R2070 T2859 T2856 punct ),al.
R2071 T2999 T2999 ROOT al.,al.
R2072 T3000 T2999 punct ",",al.
R2073 T3001 T2999 npadvmod 2008,al.
R2074 T2860 T2847 punct .,participates
R2075 T3002 T2999 punct ),al.
R2076 T3003 T2999 punct .,al.
R2077 T3004 T3005 det The,initiation
R2078 T3005 T3009 nsubj initiation,fails
R2079 T3055 T3057 compound MGMT,expression
R2080 T3006 T3005 prep of,initiation
R2081 T3007 T3008 amod apoptotic,signaling
R2082 T3008 T3006 pobj signaling,of
R2083 T3009 T3009 ROOT fails,fails
R2084 T3010 T3009 prep in,fails
R2085 T3056 T3057 compound protein,expression
R2086 T3011 T3012 det the,absence
R2087 T3012 T3010 pobj absence,in
R2088 T3013 T3012 prep of,absence
R2089 T3057 T3054 dobj expression,blocks
R2090 T3014 T3016 det the,system
R2091 T3015 T3016 compound MMR,system
R2092 T3016 T3013 pobj system,of
R2093 T3058 T3059 punct ",",prolongs
R2094 T3017 T3009 punct .,fails
R2095 T3018 T3023 nsubjpass Sensitivity,associated
R2096 T3019 T3018 prep to,Sensitivity
R2097 T3059 T3059 ROOT prolongs,prolongs
R2098 T3020 T3019 pobj TMZ,to
R2099 T3060 T3062 compound cancer,survival
R2100 T3061 T3062 compound patient,survival
R2101 T3021 T3023 auxpass is,associated
R2102 T3022 T3023 advmod significantly,associated
R2103 T3062 T3059 dobj survival,prolongs
R2104 T3023 T3023 ROOT associated,associated
R2105 T3024 T3023 prep with,associated
R2106 T3025 T3027 det the,status
R2107 T3026 T3027 amod methylation,status
R2108 T3027 T3024 pobj status,with
R2109 T3028 T3027 prep of,status
R2110 T3063 T3059 punct .,prolongs
R2111 T3029 T3031 compound MGMT,promoter
R2112 T3030 T3031 compound gene,promoter
R2113 T3031 T3028 pobj promoter,of
R2114 T3064 T3068 advmod Intriguingly,reduces
R2115 T3032 T3027 prep in,status
R2116 T3033 T3032 pobj cells,in
R2117 T3065 T3068 punct ",",reduces
R2118 T3034 T3033 acl committed,cells
R2119 T3035 T3034 prep to,committed
R2120 T3036 T3035 pobj differentiation,to
R2121 T3066 T3067 amod overexpressed,microRNA-21
R2122 T3037 T3040 punct (,al.
R2123 T3038 T3040 compound Villalva,al.
R2124 T3039 T3040 nmod et,al.
R2125 T3067 T3068 nsubj microRNA-21,reduces
R2126 T3040 T3027 appos al.,status
R2127 T3041 T3040 punct ",",al.
R2128 T3042 T3040 npadvmod 2012,al.
R2129 T3068 T3068 ROOT reduces,reduces
R2130 T3043 T3023 punct ),associated
R2131 T3044 T3023 punct .,associated
R2132 T3045 T3046 det An,increase
R2133 T3069 T3071 nmod Bax/Bcl,ratio
R2134 T3046 T3059 nsubj increase,prolongs
R2135 T3047 T3046 prep in,increase
R2136 T3048 T3051 compound MGMT,methylation
R2137 T3070 T3069 nummod -2,Bax/Bcl
R2138 T3049 T3050 compound gene,promoter
R2139 T3050 T3051 compound promoter,methylation
R2140 T3051 T3047 pobj methylation,in
R2141 T3071 T3068 dobj ratio,reduces
R2142 T3052 T3051 punct ",",methylation
R2143 T3053 T3054 nsubj which,blocks
R2144 T3054 T3051 relcl blocks,methylation
R2145 T3072 T3071 cc and,ratio
R2146 T3073 T3074 amod caspase-3,activity
R2147 T3074 T3071 conj activity,ratio
R2148 T3152 T3149 pobj target,as
R2149 T3153 T3152 prep for,target
R2150 T3075 T3068 punct ",",reduces
R2151 T3154 T3156 amod high-grade,tumors
R2152 T3155 T3156 compound brain,tumors
R2153 T3076 T3077 advmod thereby,blocking
R2154 T3156 T3153 pobj tumors,for
R2155 T3157 T3148 punct .,considered
R2156 T3158 T3162 det The,enzyme
R2157 T3159 T3162 amod base,enzyme
R2158 T3160 T3162 compound excision,enzyme
R2159 T3161 T3162 compound repair,enzyme
R2160 T3162 T3178 nsubj enzyme,participates
R2161 T3077 T3068 advcl blocking,reduces
R2162 T3163 T3162 amod alkylpurine-DNA-N-glycosylase,enzyme
R2163 T3164 T3165 punct (,APNG
R2164 T3165 T3163 appos APNG,alkylpurine-DNA-N-glycosylase
R2165 T3078 T3079 amod TMZ-induced,apoptosis
R2166 T3166 T3165 punct ),APNG
R2167 T3167 T3163 punct ",",alkylpurine-DNA-N-glycosylase
R2168 T3079 T3077 dobj apoptosis,blocking
R2169 T3168 T3169 nsubj which,repairs
R2170 T3080 T3083 punct (,al.
R2171 T3169 T3163 relcl repairs,alkylpurine-DNA-N-glycosylase
R2172 T3170 T3172 det the,lesions
R2173 T3081 T3083 compound Shi,al.
R2174 T3171 T3172 amod cytotoxic,lesions
R2175 T3172 T3169 dobj lesions,repairs
R2176 T3173 T3169 advmod N3-methyladenine,repairs
R2177 T3082 T3083 nmod et,al.
R2178 T3174 T3173 cc and,N3-methyladenine
R2179 T3083 T3083 ROOT al.,al.
R2180 T3175 T3173 conj N7-methylguanine,N3-methyladenine
R2181 T3176 T3178 punct ",",participates
R2182 T3084 T3083 punct ",",al.
R2183 T3177 T3178 advmod also,participates
R2184 T3178 T3178 ROOT participates,participates
R2185 T3179 T3178 prep in,participates
R2186 T3085 T3083 npadvmod 2010,al.
R2187 T3180 T3182 det the,resistance
R2188 T3181 T3182 compound TMZ,resistance
R2189 T3182 T3179 pobj resistance,in
R2190 T3086 T3083 punct ),al.
R2191 T3183 T3186 punct (,al.
R2192 T3184 T3186 nmod Agnihotri,al.
R2193 T3185 T3186 nmod et,al.
R2194 T3087 T3083 punct .,al.
R2195 T3186 T3178 dep al.,participates
R2196 T3187 T3186 punct ",",al.
R2197 T3188 T3186 npadvmod 2012,al.
R2198 T3088 T3090 nsubjpass MicroRNA-21,considered
R2199 T3189 T3186 punct ),al.
R2200 T3190 T3178 punct .,participates
R2201 T3191 T3191 ROOT Upregulation,Upregulation
R2202 T3089 T3090 auxpass is,considered
R2203 T3192 T3191 prep of,Upregulation
R2204 T3193 T3196 amod mitochondrial,coupling
R2205 T3090 T3090 ROOT considered,considered
R2206 T3194 T3195 amod respiratory,chain
R2207 T3195 T3196 compound chain,coupling
R2208 T3196 T3192 pobj coupling,of
R2209 T3091 T3090 prep as,considered
R2210 T3092 T3094 det a,factor
R2211 T3197 T3198 aux to,suppress
R2212 T3198 T3191 advcl suppress,Upregulation
R2213 T3093 T3094 amod pro-survival,factor
R2214 T3199 T3200 det the,production
R2215 T3200 T3198 dobj production,suppress
R2216 T3094 T3091 pobj factor,as
R2217 T3201 T3200 prep of,production
R2218 T3202 T3204 amod reactive,species
R2219 T3203 T3204 compound oxygen,species
R2220 T3095 T3094 prep for,factor
R2221 T3204 T3201 pobj species,of
R2222 T3205 T3208 punct (,regulated
R2223 T3206 T3208 dep ROS,regulated
R2224 T3096 T3097 compound cancer,cells
R2225 T3207 T3208 punct ),regulated
R2226 T3097 T3095 pobj cells,for
R2227 T3208 T3198 advcl regulated,suppress
R2228 T3098 T3101 punct (,al.
R2229 T3209 T3208 agent by,regulated
R2230 T3210 T3212 compound cytochrome,oxidase
R2231 T3211 T3212 compound c,oxidase
R2232 T3099 T3101 compound Li,al.
R2233 T3212 T3209 pobj oxidase,by
R2234 T3213 T3208 punct contributes,regulated
R2235 T3100 T3101 nmod et,al.
R2236 T3214 T3213 prep in,contributes
R2237 T3215 T3214 pobj part,in
R2238 T3216 T3215 prep to,part
R2239 T3101 T3094 appos al.,factor
R2240 T3217 T3218 compound TMZ,resistance
R2241 T3218 T3216 pobj resistance,to
R2242 T3219 T3218 prep in,resistance
R2243 T3102 T3101 punct ",",al.
R2244 T3220 T3219 pobj gliomas,in
R2245 T3221 T3224 punct (,al.
R2246 T3222 T3224 compound Oliva,al.
R2247 T3103 T3101 npadvmod 2012,al.
R2248 T3223 T3224 nmod et,al.
R2249 T3224 T3208 dep al.,regulated
R2250 T3104 T3101 punct ),al.
R2251 T3225 T3224 punct ",",al.
R2252 T3226 T3224 npadvmod 2011,al.
R2253 T3227 T3224 punct ),al.
R2254 T3105 T3090 punct .,considered
R2255 T3228 T3191 punct .,Upregulation
R2256 T3229 T3235 nsubjpass Reversal,achieved
R2257 T3230 T3229 prep of,Reversal
R2258 T3231 T3230 pobj TMZ,of
R2259 T3232 T3235 nsubjpass resistance,achieved
R2260 T3233 T3235 aux may,achieved
R2261 T3106 T3107 nsubj Integrins,play
R2262 T3234 T3235 auxpass be,achieved
R2263 T3235 T3235 ROOT achieved,achieved
R2264 T3236 T3235 agent by,achieved
R2265 T3107 T3107 ROOT play,play
R2266 T3237 T3238 compound MGMT,pseudosubstrates
R2267 T3238 T3236 pobj pseudosubstrates,by
R2268 T3239 T3238 punct ",",pseudosubstrates
R2269 T3108 T3109 det a,role
R2270 T3240 T3238 conj O6-benzylguanine,pseudosubstrates
R2271 T3241 T3240 cc and,O6-benzylguanine
R2272 T3109 T3107 dobj role,play
R2273 T3242 T3240 conj lomeguatrib,O6-benzylguanine
R2274 T3243 T3244 aux to,sensitize
R2275 T3244 T3235 xcomp sensitize,achieved
R2276 T3245 T3244 dobj tumors,sensitize
R2277 T3110 T3109 prep in,role
R2278 T3246 T3244 prep to,sensitize
R2279 T3111 T3112 det the,resistance
R2280 T3247 T3246 pobj TMZ,to
R2281 T3112 T3110 pobj resistance,in
R2282 T3113 T3112 prep of,resistance
R2283 T3248 T3251 punct (,al.
R2284 T3114 T3115 amod advanced,cancers
R2285 T3115 T3113 pobj cancers,of
R2286 T3249 T3251 compound Zhang,al.
R2287 T3250 T3251 nmod et,al.
R2288 T3116 T3117 aux to,radiotherapy
R2289 T3251 T3246 parataxis al.,to
R2290 T3252 T3251 punct ",",al.
R2291 T3253 T3251 amod 2012b,al.
R2292 T3117 T3115 relcl radiotherapy,cancers
R2293 T3254 T3251 punct ),al.
R2294 T3255 T3235 punct .,achieved
R2295 T3118 T3117 cc and,radiotherapy
R2296 T3119 T3117 conj chemotherapy,radiotherapy
R2297 T3256 T3261 nsubj Methoxyamine-blocker,contributes
R2298 T3120 T3107 punct .,play
R2299 T3257 T3256 prep of,Methoxyamine-blocker
R2300 T3258 T3260 compound base,repair
R2301 T3259 T3260 compound excision,repair
R2302 T3121 T3122 amod α5β1,integrin
R2303 T3260 T3257 pobj repair,of
R2304 T3261 T3261 ROOT contributes,contributes
R2305 T3262 T3261 advmod significantly,contributes
R2306 T3122 T3124 nsubj integrin,regulates
R2307 T3263 T3261 prep to,contributes
R2308 T3264 T3265 compound TMZ,cytotoxicity
R2309 T3265 T3263 pobj cytotoxicity,to
R2310 T3266 T3271 advmod particularly,repaired
R2311 T3267 T3271 advmod when,repaired
R2312 T3268 T3269 amod O6-methylguanine,adducts
R2313 T3123 T3124 advmod negatively,regulates
R2314 T3269 T3271 nsubjpass adducts,repaired
R2315 T3270 T3271 auxpass are,repaired
R2316 T3271 T3261 advcl repaired,contributes
R2317 T3124 T3124 ROOT regulates,regulates
R2318 T3272 T3271 cc or,repaired
R2319 T3273 T3271 conj tolerated,repaired
R2320 T3274 T3283 punct (,al.
R2321 T3275 T3277 nmod Goellner,al.
R2322 T3125 T3124 dobj p53,regulates
R2323 T3276 T3277 nmod et,al.
R2324 T3277 T3283 ccomp al.,al.
R2325 T3126 T3125 acl signaling,p53
R2326 T3278 T3277 punct ",",al.
R2327 T3279 T3277 npadvmod 2011,al.
R2328 T3280 T3283 punct ;,al.
R2329 T3127 T3124 punct ",",regulates
R2330 T3281 T3283 compound Zhang,al.
R2331 T3282 T3283 nmod et,al.
R2332 T3283 T3283 ROOT al.,al.
R2333 T3128 T3124 cc and,regulates
R2334 T3284 T3285 punct ",",2012b
R2335 T3285 T3283 amod 2012b,al.
R2336 T3286 T3285 punct ),2012b
R2337 T3129 T3130 det the,event
R2338 T3287 T3261 punct .,contributes
R2339 T3130 T3131 nsubj event,induces
R2340 T3288 T3289 amod Dual,targeting
R2341 T3131 T3124 conj induces,regulates
R2342 T3132 T3134 amod glioma,resistance
R2343 T3289 T3301 nsubj targeting,reverse
R2344 T3290 T3289 prep of,targeting
R2345 T3291 T3293 compound base,repair
R2346 T3133 T3134 compound cell,resistance
R2347 T3292 T3293 compound excision,repair
R2348 T3293 T3290 pobj repair,of
R2349 T3134 T3131 dobj resistance,induces
R2350 T3294 T3293 cc and,repair
R2351 T3295 T3299 nmod NAD,biosynthesis
R2352 T3296 T3297 punct (,+
R2353 T3135 T3134 prep to,resistance
R2354 T3297 T3295 parataxis +,NAD
R2355 T3298 T3299 punct ),biosynthesis
R2356 T3299 T3293 conj biosynthesis,repair
R2357 T3300 T3301 aux may,reverse
R2358 T3136 T3135 pobj TMZ,to
R2359 T3301 T3301 ROOT reverse,reverse
R2360 T3302 T3303 compound TMZ,resistance
R2361 T3303 T3301 dobj resistance,reverse
R2362 T3304 T3301 prep in,reverse
R2363 T3305 T3304 pobj patients,in
R2364 T3306 T3305 prep with,patients
R2365 T3137 T3140 punct (,al.
R2366 T3307 T3310 amod resistant,GBM
R2367 T3308 T3307 cc and,resistant
R2368 T3309 T3307 conj recurrent,resistant
R2369 T3138 T3140 nmod Janouskova,al.
R2370 T3310 T3306 pobj GBM,with
R2371 T3311 T3310 punct (,GBM
R2372 T3312 T3314 nmod Goellner,al.
R2373 T3139 T3140 nmod et,al.
R2374 T3313 T3314 nmod et,al.
R2375 T3314 T3301 dep al.,reverse
R2376 T3140 T3134 appos al.,resistance
R2377 T3141 T3140 punct ",",al.
R2378 T3315 T3314 punct ",",al.
R2379 T3142 T3140 npadvmod 2012,al.
R2380 T3316 T3314 npadvmod 2011,al.
R2381 T3317 T3314 punct ),al.
R2382 T3318 T3301 punct .,reverse
R2383 T3319 T3337 nsubj Interferon-β,increase
R2384 T3143 T3131 punct ),induces
R2385 T3320 T3321 punct (,IFN-β
R2386 T3321 T3319 appos IFN-β,Interferon-β
R2387 T3322 T3321 punct ),IFN-β
R2388 T3144 T3124 punct .,regulates
R2389 T3323 T3319 punct ",",Interferon-β
R2390 T3324 T3319 appos levetiracetam,Interferon-β
R2391 T3325 T3326 punct (,LEV
R2392 T3145 T3146 amod α5β1,integrin
R2393 T3326 T3324 appos LEV,levetiracetam
R2394 T3327 T3326 punct ),LEV
R2395 T3328 T3324 punct ",",levetiracetam
R2396 T3146 T3148 nsubjpass integrin,considered
R2397 T3329 T3324 conj resveratrol,levetiracetam
R2398 T3330 T3329 punct ",",resveratrol
R2399 T3331 T3329 cc and,resveratrol
R2400 T3147 T3148 auxpass is,considered
R2401 T3332 T3333 amod valproic,acid
R2402 T3333 T3329 conj acid,resveratrol
R2403 T3334 T3333 punct (,acid
R2404 T3335 T3337 nsubj VAP,increase
R2405 T3148 T3148 ROOT considered,considered
R2406 T3336 T3337 punct ),increase
R2407 T3337 T3337 ROOT increase,increase
R2408 T3149 T3148 prep as,considered
R2409 T3338 T3339 det the,sensitivity
R2410 T3339 T3337 dobj sensitivity,increase
R2411 T3340 T3339 prep of,sensitivity
R2412 T3341 T3340 pobj TMZ,of
R2413 T3342 T3337 prep through,increase
R2414 T3150 T3152 det a,target
R2415 T3343 T3342 pobj MGMT-dependent,through
R2416 T3344 T3343 cc or,MGMT-dependent
R2417 T3345 T3346 punct -,independent
R2418 T3151 T3152 amod therapeutic,target
R2419 T3443 T3442 prep in,failure
R2420 T3346 T3347 amod independent,mechanisms
R2421 T3347 T3343 conj mechanisms,MGMT-dependent
R2422 T3348 T3347 punct (,mechanisms
R2423 T3444 T3445 compound TMZ,treatment
R2424 T3349 T3351 compound Nakada,al.
R2425 T3350 T3351 nmod et,al.
R2426 T3351 T3347 appos al.,mechanisms
R2427 T3445 T3443 pobj treatment,in
R2428 T3352 T3351 punct ",",al.
R2429 T3353 T3351 npadvmod 2012,al.
R2430 T3446 T3437 punct .,are
R2431 T3354 T3347 punct ),mechanisms
R2432 T3447 T3448 det The,concept
R2433 T3355 T3337 punct .,increase
R2434 T3356 T3362 nsubj Resveratrol,reverses
R2435 T3357 T3356 punct ",",Resveratrol
R2436 T3448 T3478 nsubjpass concept,al.
R2437 T3358 T3360 det a,polyphenol
R2438 T3359 T3360 amod natural,polyphenol
R2439 T3360 T3356 appos polyphenol,Resveratrol
R2440 T3361 T3356 punct ",",Resveratrol
R2441 T3449 T3448 prep of,concept
R2442 T3362 T3362 ROOT reverses,reverses
R2443 T3363 T3364 compound TMZ,resistance
R2444 T3450 T3452 compound cancer,cell
R2445 T3364 T3362 dobj resistance,reverses
R2446 T3365 T3362 prep via,reverses
R2447 T3366 T3368 det an,mechanism
R2448 T3451 T3452 compound stem,cell
R2449 T3367 T3368 amod NF-κB-dependent,mechanism
R2450 T3368 T3365 pobj mechanism,via
R2451 T3369 T3368 punct (,mechanism
R2452 T3452 T3453 compound cell,survival
R2453 T3370 T3372 compound Huang,al.
R2454 T3371 T3372 nmod et,al.
R2455 T3453 T3449 pobj survival,of
R2456 T3372 T3368 appos al.,mechanism
R2457 T3373 T3372 punct ",",al.
R2458 T3374 T3372 npadvmod 2012,al.
R2459 T3454 T3448 prep from,concept
R2460 T3375 T3368 punct ),mechanism
R2461 T3376 T3362 punct .,reverses
R2462 T3377 T3378 nummod STAT3,inhibitor
R2463 T3378 T3384 nmod inhibitor,efficacy
R2464 T3379 T3378 cc or,inhibitor
R2465 T3380 T3382 nummod STAT3,potentiates
R2466 T3381 T3382 amod knockdown,potentiates
R2467 T3455 T3454 pobj treatment,from
R2468 T3382 T3378 conj potentiates,inhibitor
R2469 T3383 T3384 compound TMZ,efficacy
R2470 T3384 T3384 ROOT efficacy,efficacy
R2471 T3456 T3448 prep with,concept
R2472 T3385 T3384 prep in,efficacy
R2473 T3386 T3389 amod resistant,lines
R2474 T3457 T3456 pobj TMZ,with
R2475 T3387 T3389 nmod GBM,lines
R2476 T3388 T3389 compound cell,lines
R2477 T3389 T3385 pobj lines,in
R2478 T3458 T3457 cc and,TMZ
R2479 T3390 T3389 punct (,lines
R2480 T3391 T3393 compound Kohsaka,al.
R2481 T3392 T3393 nmod et,al.
R2482 T3459 T3461 amod other,drugs
R2483 T3393 T3389 appos al.,lines
R2484 T3460 T3461 amod chemotherapeutic,drugs
R2485 T3394 T3393 punct ",",al.
R2486 T3461 T3457 conj drugs,TMZ
R2487 T3395 T3393 npadvmod 2012,al.
R2488 T3396 T3389 punct ),lines
R2489 T3462 T3463 aux has,been
R2490 T3397 T3384 punct .,efficacy
R2491 T3398 T3399 compound Intratumoral,hypoxia
R2492 T3399 T3400 nsubj hypoxia,is
R2493 T3463 T3478 auxpass been,al.
R2494 T3400 T3400 ROOT is,is
R2495 T3401 T3400 acomp common,is
R2496 T3464 T3465 advmod more,complicated
R2497 T3402 T3400 prep in,is
R2498 T3403 T3402 pobj GBMs,in
R2499 T3465 T3478 ccomp complicated,al.
R2500 T3404 T3400 cc and,is
R2501 T3405 T3407 aux may,associated
R2502 T3406 T3407 auxpass be,associated
R2503 T3466 T3468 mark than,thought
R2504 T3407 T3400 conj associated,is
R2505 T3408 T3407 prep with,associated
R2506 T3409 T3410 det the,development
R2507 T3467 T3468 advmod previously,thought
R2508 T3410 T3408 pobj development,with
R2509 T3411 T3410 prep of,development
R2510 T3412 T3413 compound TMZ,resistance
R2511 T3413 T3411 pobj resistance,of
R2512 T3414 T3400 punct .,is
R2513 T3415 T3416 amod Induced,hyperoxia
R2514 T3468 T3465 advcl thought,complicated
R2515 T3416 T3419 nsubjpass hyperoxia,utilized
R2516 T3417 T3419 aux can,utilized
R2517 T3418 T3419 auxpass be,utilized
R2518 T3419 T3419 ROOT utilized,utilized
R2519 T3469 T3465 punct (,complicated
R2520 T3420 T3421 aux to,reverse
R2521 T3421 T3419 xcomp reverse,utilized
R2522 T3422 T3423 compound TMZ,resistance
R2523 T3470 T3472 nmod Beier,al.
R2524 T3423 T3421 dobj resistance,reverse
R2525 T3424 T3421 prep in,reverse
R2526 T3425 T3424 pobj GBMs,in
R2527 T3471 T3472 nmod et,al.
R2528 T3472 T3465 punct al.,complicated
R2529 T3426 T3429 punct (,al.
R2530 T3473 T3472 punct ",",al.
R2531 T3427 T3429 nmod Sun,al.
R2532 T3428 T3429 nmod et,al.
R2533 T3429 T3419 parataxis al.,utilized
R2534 T3474 T3472 npadvmod 2011,al.
R2535 T3430 T3429 punct ",",al.
R2536 T3431 T3429 npadvmod 2012,al.
R2537 T3475 T3478 punct ;,al.
R2538 T3432 T3429 punct ),al.
R2539 T3433 T3419 punct .,utilized
R2540 T3434 T3436 compound Cancer,cells
R2541 T3476 T3478 compound Chen,al.
R2542 T3435 T3436 compound stem,cells
R2543 T3436 T3437 nsubj cells,are
R2544 T3437 T3437 ROOT are,are
R2545 T3477 T3478 compound et,al.
R2546 T3478 T3478 ROOT al.,al.
R2547 T3479 T3478 punct ",",al.
R2548 T3438 T3437 advmod probably,are
R2549 T3439 T3440 det the,key
R2550 T3480 T3478 npadvmod 2012,al.
R2551 T3440 T3437 attr key,are
R2552 T3441 T3440 prep to,key
R2553 T3481 T3478 punct ),al.
R2554 T3442 T3441 pobj failure,to
R2555 T3482 T3478 punct .,al.
R2556 T3483 T3486 amod CD133-positive,cells
R2557 T3484 T3485 compound cancer,stem
R2558 T3485 T3486 compound stem,cells
R2559 T3488 T3488 ROOT expressed,expressed
R2560 T3489 T3488 prep in,expressed
R2561 T3490 T3493 det both,cells
R2562 T3491 T3493 amod normal,cells
R2563 T3486 T3488 nsubjpass cells,expressed
R2564 T3492 T3493 compound stem,cells
R2565 T3493 T3489 pobj cells,in
R2566 T3494 T3493 cc and,cells
R2567 T3495 T3496 compound cancer,stem
R2568 T3487 T3488 auxpass are,expressed
R2569 T3496 T3497 compound stem,cells
R2570 T3497 T3493 conj cells,cells
R2571 T3498 T3488 punct (,expressed
R2572 T3499 T3488 dep Donovan,expressed
R2573 T3500 T3499 cc and,Donovan
R2574 T3501 T3499 conj Pilkington,Donovan
R2575 T3502 T3501 punct ",",Pilkington
R2576 T3503 T3501 npadvmod 2012,Pilkington
R2577 T3504 T3501 punct ),Pilkington
R2578 T3505 T3488 punct .,expressed
R2579 T3506 T3529 advmod However,established
R2580 T3507 T3529 punct ",",established
R2581 T3508 T3509 det the,role
R2582 T3509 T3529 nsubjpass role,established
R2583 T3510 T3509 prep of,role
R2584 T3511 T3510 pobj CD133,of
R2585 T3512 T3509 prep as,role
R2586 T3513 T3514 det a,marker
R2587 T3514 T3512 pobj marker,as
R2588 T3515 T3514 prep for,marker
R2589 T3516 T3519 amod glioma,cells
R2590 T3517 T3518 compound cancer,stem
R2591 T3518 T3519 compound stem,cells
R2592 T3519 T3515 pobj cells,for
R2593 T3520 T3519 amod relative,cells
R2594 T3521 T3520 prep to,relative
R2595 T3522 T3524 poss its,function
R2596 T3523 T3524 amod biological,function
R2597 T3524 T3521 pobj function,to
R2598 T3525 T3529 aux has,established
R2599 T3526 T3529 advmod yet,established
R2600 T3527 T3529 aux to,established
R2601 T3528 T3529 auxpass be,established
R2602 T3529 T3529 ROOT established,established
R2603 T3530 T3529 punct .,established
R265 T552 T554 compound Tumor,WWOX
R266 T553 T554 compound Suppressor,WWOX
R267 T554 T568 nsubjpass WWOX,mutated
R268 T555 T554 cc and,WWOX
R269 T556 T557 compound p53,Alterations
R270 T557 T554 conj Alterations,WWOX
R271 T558 T557 cc and,Alterations
R272 T559 T560 compound Drug,Resistance
R273 T560 T557 conj Resistance,Alterations
R274 T561 T557 prep in,Alterations
R275 T562 T565 compound Glioblastomas,p53
R276 T563 T565 compound Tumor,p53
R277 T564 T565 compound suppressor,p53
R278 T565 T561 pobj p53,in
R279 T566 T568 auxpass are,mutated
R280 T567 T568 advmod frequently,mutated
R281 T568 T568 ROOT mutated,mutated
R282 T569 T568 prep in,mutated
R283 T570 T569 pobj glioblastomas,in
R284 T571 T572 punct (,GBMs
R285 T572 T570 appos GBMs,glioblastomas
R286 T573 T568 punct ),mutated
R287 T574 T568 cc and,mutated
R288 T575 T568 conj appears,mutated
R289 T576 T577 aux to,contribute
R290 T577 T575 xcomp contribute,appears
R291 T578 T577 punct ",",contribute
R292 T579 T575 prep in,appears
R293 T580 T579 pobj part,in
R294 T581 T575 punct ",",appears
R295 T582 T583 aux to,resistance
R296 T583 T568 advcl resistance,mutated
R297 T584 T585 aux to,temozolomide
R298 T585 T583 advcl temozolomide,resistance
R299 T586 T587 punct (,TMZ
R300 T587 T585 appos TMZ,temozolomide
R301 T588 T587 punct ),TMZ
R302 T589 T585 cc and,temozolomide
R303 T590 T591 amod therapeutic,drugs
R304 T591 T585 conj drugs,temozolomide
R305 T592 T568 punct .,mutated
R306 T593 T596 compound WW,WWOX
R307 T594 T596 compound domain-containing,WWOX
R308 T595 T596 compound oxidoreductase,WWOX
R309 T596 T602 nsubj WWOX,is
R310 T597 T598 punct (,FOR
R311 T598 T596 prep FOR,WWOX
R312 T599 T598 cc or,FOR
R313 T600 T598 conj WOX1,FOR
R314 T601 T598 punct ),FOR
R315 T602 T602 ROOT is,is
R316 T603 T605 det a,protein
R317 T604 T605 amod proapoptotic,protein
R318 T605 T602 attr protein,is
R319 T606 T602 cc and,is
R320 T607 T608 auxpass is,considered
R321 T608 T602 conj considered,is
R322 T609 T608 prep as,considered
R323 T610 T612 det a,suppressor
R324 T611 T612 compound tumor,suppressor
R325 T612 T609 pobj suppressor,as
R326 T613 T602 punct .,is
R327 T614 T621 nsubjpass Loss,seen
R328 T615 T614 prep of,Loss
R329 T616 T618 compound WWOX,expression
R330 T618 T615 pobj expression,of
R331 T619 T621 auxpass is,seen
R332 T620 T621 advmod frequently,seen
R333 T621 T621 ROOT seen,seen
R334 T622 T621 prep in,seen
R335 T623 T625 amod malignant,cells
R336 T624 T625 compound cancer,cells
R337 T625 T622 pobj cells,in
R338 T626 T621 prep due,seen
R339 T627 T628 aux to,promoter
R340 T628 T626 xcomp promoter,due
R341 T629 T626 conj hypermethylation,due
R342 T630 T629 punct ",",hypermethylation
R343 T631 T632 amod genetic,alterations
R344 T632 T629 conj alterations,hypermethylation
R345 T633 T632 punct ",",alterations
R346 T634 T632 cc and,alterations
R347 T635 T636 amod translational,blockade
R348 T636 T632 conj blockade,alterations
R349 T637 T621 punct .,seen
R350 T638 T647 advmod Intriguingly,induces
R351 T639 T641 punct ",",expression
R352 T640 T641 amod ectopic,expression
R353 T641 T647 nsubj expression,induces
R354 T642 T641 prep of,expression
R355 T643 T644 amod wild,type
R356 T644 T645 compound type,WWOX
R357 T645 T642 pobj WWOX,of
R358 T646 T647 advmod preferentially,induces
R359 T647 T647 ROOT induces,induces
R360 T648 T647 dobj apoptosis,induces
R361 T649 T648 prep in,apoptosis
R362 T650 T652 amod human,cells
R363 T651 T652 compound glioblastoma,cells
R364 T652 T649 pobj cells,in
R365 T653 T648 acl harboring,apoptosis
R366 T654 T655 amod mutant,p53
R367 T655 T653 dobj p53,harboring
R368 T656 T647 punct .,induces
R369 T657 T659 nsubjpass WWOX,known
R370 T658 T659 auxpass is,known
R371 T659 T659 ROOT known,known
R372 T660 T662 aux to,bind
R373 T661 T662 advmod physically,bind
R374 T662 T659 xcomp bind,known
R375 T663 T659 cc and,known
R376 T664 T659 conj stabilize,known
R377 T665 T666 amod wild,type
R378 T666 T667 compound type,p53
R379 T667 T664 dobj p53,stabilize
R380 T668 T659 punct .,known
R381 T669 T672 advmod Here,provide
R382 T670 T672 punct ",",provide
R383 T671 T672 nsubj we,provide
R384 T672 T672 ROOT provide,provide
R385 T673 T674 det an,overview
R386 T674 T672 dobj overview,provide
R387 T675 T674 prep for,overview
R388 T676 T678 det the,knowledge
R389 T677 T678 amod updated,knowledge
R3890 T5791 T5790 punct ",",al.
R3894 T5771 T5779 advmod Recently,shown
R3895 T5772 T5779 punct ",",shown
R3896 T5773 T5775 nmod tumor,p53
R3897 T5774 T5775 compound suppressors,p53
R3898 T5775 T5779 nsubjpass p53,shown
R3899 T5776 T5775 cc and,p53
R390 T678 T675 pobj knowledge,for
R3900 T5777 T5775 conj WWOX,p53
R3901 T5792 T5790 npadvmod 2012,al.
R3902 T5778 T5779 auxpass were,shown
R3903 T5779 T5779 ROOT shown,shown
R3904 T5780 T5781 aux to,regulate
R3905 T5793 T5783 punct ),apoptosis
R3906 T5781 T5779 xcomp regulate,shown
R3907 T5782 T5783 det the,apoptosis
R3908 T5783 T5781 dobj apoptosis,regulate
R3909 T5794 T5779 punct .,shown
R391 T679 T678 prep in,knowledge
R3910 T5784 T5783 prep of,apoptosis
R3911 T5785 T5786 compound glioblastoma,cells
R3912 T5786 T5784 pobj cells,of
R3913 T5787 T5790 punct (,al.
R3914 T5795 T5797 nmod WW,oxidoreductase
R3915 T5788 T5790 compound Chiang,al.
R3916 T5789 T5790 nmod et,al.
R3917 T5790 T5783 appos al.,apoptosis
R3918 T5796 T5797 amod domain-containing,oxidoreductase
R3919 T5797 T5809 nsubjpass oxidoreductase,encoded
R392 T680 T679 pobj p53,in
R3920 T5798 T5797 punct ",",oxidoreductase
R3921 T5835 T5834 appos FRA16D,site
R3922 T5799 T5797 acl known,oxidoreductase
R3923 T5836 T5820 punct .,located
R3924 T5837 T5840 det The,protein
R3925 T5800 T5799 prep as,known
R3926 T5838 T5840 amod full-length,protein
R3927 T5839 T5840 compound WWOX,protein
R3928 T5840 T5842 nsubjpass protein,composed
R3929 T5801 T5800 pobj WWOX,as
R393 T681 T680 cc and,p53
R3930 T5841 T5842 auxpass is,composed
R3931 T5842 T5842 ROOT composed,composed
R3932 T5843 T5842 prep of,composed
R3933 T5802 T5809 punct ",",encoded
R3934 T5844 T5847 nummod two,domains
R3935 T5845 T5847 amod N-terminal,domains
R3936 T5846 T5847 compound WW,domains
R3937 T5803 T5809 prep FOR,encoded
R3938 T5847 T5843 pobj domains,of
R3939 T5848 T5847 punct ",",domains
R394 T682 T680 conj WWOX,p53
R3940 T5849 T5853 det a,dehydrogenase/reductase
R3941 T5804 T5803 punct ",",FOR
R3942 T5850 T5853 amod C-terminal,dehydrogenase/reductase
R3943 T5805 T5803 cc or,FOR
R3944 T5851 T5853 compound short-chain,dehydrogenase/reductase
R3945 T5852 T5853 compound alcohol,dehydrogenase/reductase
R3946 T5853 T5847 appos dehydrogenase/reductase,domains
R3947 T5854 T5855 punct (,SDR
R3948 T5806 T5809 nsubjpass WOX1,encoded
R3949 T5855 T5853 appos SDR,dehydrogenase/reductase
R395 T683 T682 punct ",",WWOX
R3950 T5856 T5855 punct ),SDR
R3951 T5857 T5853 conj domain,dehydrogenase/reductase
R3952 T5807 T5809 punct ",",encoded
R3953 T5858 T5857 punct ",",domain
R3954 T5859 T5857 cc and,domain
R3955 T5860 T5864 det a,D3
R3956 T5808 T5809 auxpass is,encoded
R3957 T5861 T5864 amod proapoptotic,D3
R3958 T5862 T5863 amod C-terminal,tail
R3959 T5863 T5864 compound tail,D3
R396 T684 T672 cc and,provide
R3960 T5809 T5809 ROOT encoded,encoded
R3961 T5864 T5857 conj D3,domain
R3962 T5865 T5868 punct (,al.
R3963 T5866 T5868 compound Chang,al.
R3964 T5810 T5809 agent by,encoded
R3965 T5867 T5868 nmod et,al.
R3966 T5868 T5864 appos al.,D3
R3967 T5869 T5868 punct ",",al.
R3968 T5811 T5815 amod human,gene
R3969 T5870 T5868 appos 2001,al.
R397 T685 T672 conj postulate,provide
R3970 T5871 T5870 punct ",",2001
R3971 T5872 T5870 conj 2007,2001
R3972 T5812 T5811 cc or,human
R3973 T5873 T5872 punct ",",2007
R3974 T5874 T5872 conj 2010,2007
R3975 T5813 T5811 conj mouse,human
R3976 T5875 T5847 punct ;,domains
R3977 T5876 T5878 compound Aqeilan,al.
R3978 T5877 T5878 compound et,al.
R3979 T5814 T5815 compound WWOX/Wwox,gene
R398 T686 T687 amod potential,scenarios
R3980 T5878 T5847 appos al.,domains
R3981 T5879 T5878 punct ",",al.
R3982 T5815 T5810 pobj gene,by
R3983 T5880 T5878 appos 2004,al.
R3984 T5881 T5880 punct ",",2004
R3985 T5882 T5880 conj 2007,2004
R3986 T5816 T5809 punct .,encoded
R3987 T5883 T5847 punct ;,domains
R3988 T5884 T5886 compound Hong,al.
R3989 T5817 T5818 det This,gene
R399 T687 T685 dobj scenarios,postulate
R3990 T5885 T5886 nmod et,al.
R3991 T5886 T5847 appos al.,domains
R3992 T5887 T5886 punct ",",al.
R3993 T5818 T5820 nsubjpass gene,located
R3994 T5888 T5886 npadvmod 2007,al.
R3995 T5889 T5847 punct ;,domains
R3996 T5890 T5892 compound Salah,al.
R3997 T5819 T5820 auxpass is,located
R3998 T5891 T5892 nmod et,al.
R3999 T5892 T5847 appos al.,domains
R400 T688 T698 nsubj that,modulate
R4000 T5893 T5892 punct ",",al.
R4001 T5820 T5820 ROOT located,located
R4002 T5894 T5892 npadvmod 2012,al.
R4003 T5895 T5847 punct ),domains
R4004 T5821 T5820 prep in,located
R4005 T5896 T5847 punct (,domains
R4006 T5897 T5847 appos Figure,domains
R4007 T5898 T5897 nummod 1,Figure
R4008 T5822 T5821 pobj chromosome,in
R4009 T5899 T5847 punct ),domains
R401 T689 T690 amod wild,type
R4010 T5900 T5842 punct .,composed
R4011 T5901 T5903 nsubj WWOX,act
R4012 T5823 T5822 nummod 16q23,chromosome
R4013 T5902 T5903 aux may,act
R4014 T5903 T5937 ccomp act,al.
R4015 T5904 T5903 prep as,act
R4016 T5905 T5907 det an,receptor
R4017 T5824 T5822 nummod .3,chromosome
R4018 T5906 T5907 amod alternative,receptor
R4019 T5907 T5904 pobj receptor,as
R402 T690 T698 nsubj type,modulate
R4020 T5825 T5820 npadvmod 24.1,located
R4021 T5908 T5907 prep for,receptor
R4022 T5909 T5911 compound sex,hormones
R4023 T5910 T5911 compound steroid,hormones
R4024 T5911 T5908 pobj hormones,for
R4025 T5912 T5903 punct ",",act
R4026 T5913 T5917 mark since,possesses
R4027 T5826 T5825 punct ",",24.1
R4028 T5914 T5916 poss its,domain
R4029 T5915 T5916 compound SDR,domain
R403 T691 T690 cc and,type
R4030 T5916 T5917 nsubj domain,possesses
R4031 T5827 T5828 det an,area
R4032 T5917 T5903 advcl possesses,act
R4033 T5918 T5920 det an,motif
R4034 T5919 T5920 compound NSYK,motif
R4035 T5828 T5825 npadvmod area,24.1
R4036 T5920 T5917 dobj motif,possesses
R4037 T5921 T5920 amod capable,motif
R4038 T5922 T5921 prep of,capable
R4039 T5829 T5828 acl known,area
R404 T692 T693 amod mutant,p53
R4040 T5923 T5922 pcomp interacting,of
R4041 T5924 T5923 prep with,interacting
R4042 T5925 T5924 pobj androgen,with
R4043 T5830 T5829 prep as,known
R4044 T5926 T5925 cc and,androgen
R4045 T5927 T5925 conj estrogen,androgen
R4046 T5928 T5931 punct (,al.
R4047 T5831 T5834 det the,site
R4048 T5929 T5931 compound Chang,al.
R4049 T5930 T5931 nmod et,al.
R405 T693 T690 conj p53,type
R4050 T5931 T5921 appos al.,capable
R4051 T5832 T5834 amod common,site
R4052 T5833 T5834 amod fragile,site
R4053 T5834 T5830 pobj site,as
R4054 T6029 T6033 nsubj Restoration,prevents
R4055 T5932 T5933 punct ",",2005a
R4056 T5933 T5931 amod 2005a,al.
R4057 T6030 T6029 prep of,Restoration
R4058 T5934 T5937 punct ;,al.
R4059 T5935 T5937 compound Su,al.
R406 T694 T693 punct ",",p53
R4060 T5936 T5937 nmod et,al.
R4061 T6031 T6032 compound WWOX,gene
R4062 T5937 T5937 ROOT al.,al.
R4063 T6032 T6030 pobj gene,of
R4064 T5938 T5937 punct ",",al.
R4065 T6033 T6033 ROOT prevents,prevents
R4066 T5939 T5937 npadvmod 2012,al.
R4067 T6034 T6035 det the,growth
R4068 T5940 T5937 punct ),al.
R4069 T5941 T5937 punct .,al.
R407 T695 T693 cc or,p53
R4070 T5942 T5947 nsubjpass Expression,altered
R4071 T6035 T6033 dobj growth,prevents
R4072 T5943 T5942 prep of,Expression
R4073 T5944 T5943 pobj WWOX,of
R4074 T5945 T5947 auxpass is,altered
R4075 T5946 T5947 preconj either,altered
R4076 T5947 T6013 ccomp altered,al.
R4077 T5948 T5947 cc or,altered
R4078 T6036 T6035 prep of,growth
R4079 T5949 T5947 conj lost,altered
R408 T696 T693 conj isoforms,p53
R4080 T6037 T6038 compound lung,cancer
R4081 T5950 T5949 prep from,lost
R4082 T6038 T6036 pobj cancer,of
R4083 T6039 T6042 punct (,al.
R4084 T5951 T5952 amod epigenetic,modification
R4085 T6040 T6042 compound Fabbri,al.
R4086 T6041 T6042 nmod et,al.
R4087 T5952 T5950 pobj modification,from
R4088 T6042 T6035 appos al.,growth
R4089 T6043 T6042 punct ",",al.
R409 T697 T698 punct ",",modulate
R4090 T5953 T5952 prep in,modification
R4091 T6044 T6042 npadvmod 2005,al.
R4092 T5954 T5956 amod multiple,cancers
R4093 T6045 T6035 punct ),growth
R4094 T6046 T6035 punct ",",growth
R4095 T6047 T6048 compound pancreatic,cancer
R4096 T6048 T6035 appos cancer,growth
R4097 T5955 T5956 amod malignant,cancers
R4098 T6049 T6052 punct (,al.
R4099 T5956 T5953 pobj cancers,in
R410 T698 T687 relcl modulate,scenarios
R4100 T6050 T6052 compound Nakayama,al.
R4101 T6051 T6052 nmod et,al.
R4102 T5957 T5956 punct ",",cancers
R4103 T5958 T5959 amod such,as
R4104 T6052 T6035 appos al.,growth
R4105 T5959 T5956 prep as,cancers
R4106 T5960 T5963 amod non-small,carcinoma
R4107 T6053 T6052 punct ",",al.
R4108 T5961 T5962 compound cell,lung
R4109 T5962 T5963 compound lung,carcinoma
R411 T699 T701 det the,function
R4110 T5963 T5959 pobj carcinoma,as
R4111 T6054 T6052 npadvmod 2008,al.
R4112 T5964 T5967 punct (,al.
R4113 T5965 T5967 nmod Donati,al.
R4114 T6055 T6035 punct ),growth
R4115 T5966 T5967 nmod et,al.
R4116 T5967 T5963 advmod al.,carcinoma
R4117 T5968 T5967 punct ",",al.
R4118 T6056 T6033 punct ",",prevents
R4119 T5969 T5967 npadvmod 2007,al.
R412 T700 T701 amod apoptotic,function
R4120 T5970 T5967 punct ),al.
R4121 T5971 T5963 punct ",",carcinoma
R4122 T5972 T5973 amod hematopoietic,malignancies
R4123 T5973 T5963 conj malignancies,carcinoma
R4124 T6057 T6033 cc and,prevents
R4125 T5974 T5963 punct (,carcinoma
R4126 T5975 T6003 poss Ishii,carcinoma
R4127 T5976 T5975 cc and,Ishii
R4128 T5977 T5975 conj Furukawa,Ishii
R4129 T6058 T6059 compound prostate,cancer
R413 T701 T698 dobj function,modulate
R4130 T5978 T5977 punct ",",Furukawa
R4131 T5979 T5977 npadvmod 2004,Furukawa
R4132 T5980 T5977 punct ),Furukawa
R4133 T6059 T6033 conj cancer,prevents
R4134 T5981 T5983 punct ",",carcinoma
R4135 T5982 T5983 amod gastric,carcinoma
R4136 T5983 T5975 conj carcinoma,Ishii
R4137 T6060 T6063 punct (,al.
R4138 T5984 T5983 punct (,carcinoma
R4139 T5985 T5987 amod Aqeilan,al.
R414 T702 T701 prep of,function
R4140 T6061 T6063 nmod Hong,al.
R4141 T5986 T5987 nmod et,al.
R4142 T5987 T5983 appos al.,carcinoma
R4143 T5988 T5987 punct ",",al.
R4144 T6062 T6063 nmod et,al.
R4145 T5989 T5987 pobj 2004,al.
R4146 T5990 T5983 punct ),carcinoma
R4147 T5991 T5983 punct ",",carcinoma
R4148 T6063 T6059 parataxis al.,cancer
R4149 T5992 T5993 amod pancreatic,carcinoma
R415 T703 T702 pobj WWOX,of
R4150 T5993 T5983 conj carcinoma,carcinoma
R4151 T5994 T5997 punct (,al.
R4152 T6064 T6063 punct ",",al.
R4153 T5995 T5997 nmod Kuroki,al.
R4154 T5996 T5997 nmod et,al.
R4155 T6065 T6063 npadvmod 2009,al.
R4156 T5997 T5983 appos al.,carcinoma
R4157 T5998 T5997 punct ",",al.
R4158 T5999 T5997 npadvmod 2004,al.
R4159 T6066 T6063 punct ),al.
R416 T704 T672 punct .,provide
R4160 T6000 T5983 punct ),carcinoma
R4161 T6001 T5983 punct ",",carcinoma
R4162 T6067 T6033 punct .,prevents
R4163 T6002 T6003 compound breast,carcinoma
R4164 T6003 T5963 appos carcinoma,carcinoma
R4165 T6004 T6007 punct (,al.
R4166 T6068 T6071 det The,domain
R4167 T6005 T6007 compound Guler,al.
R4168 T6006 T6007 nmod et,al.
R4169 T6007 T6003 appos al.,carcinoma
R417 T705 T706 nsubj We,propose
R4170 T6069 T6071 amod first,domain
R4171 T6008 T6007 punct ",",al.
R4172 T6009 T6007 npadvmod 2004,al.
R4173 T6010 T6013 punct ;,al.
R4174 T6011 T6013 compound Aqeilan,al.
R4175 T6012 T6013 compound et,al.
R4176 T6013 T6013 ROOT al.,al.
R4177 T6070 T6071 compound WW,domain
R4178 T6014 T6013 punct ",",al.
R4179 T6015 T6013 npadvmod 2007,al.
R418 T706 T706 ROOT propose,propose
R4180 T6016 T6013 punct ),al.
R4181 T6071 T6075 nsubj domain,interact
R4182 T6017 T6013 punct ",",al.
R4183 T6018 T6013 cc and,al.
R4184 T6019 T6020 compound glioblastoma,multiforme
R4185 T6072 T6071 prep of,domain
R4186 T6020 T6013 conj multiforme,al.
R4187 T6021 T6020 punct (,multiforme
R4188 T6022 T6024 compound Kosla,al.
R4189 T6073 T6072 pobj WWOX,of
R419 T707 T719 mark that,needed
R4190 T6023 T6024 nmod et,al.
R4191 T6024 T6020 appos al.,multiforme
R4192 T6025 T6024 punct ",",al.
R4193 T6074 T6075 aux may,interact
R4194 T6026 T6024 npadvmod 2011,al.
R4195 T6027 T6020 punct ),multiforme
R4196 T6075 T6075 ROOT interact,interact
R4197 T6028 T6013 punct .,al.
R4198 T6076 T6075 prep with,interact
R4199 T6077 T6076 pobj proteins,with
R420 T708 T719 csubj triggering,needed
R4200 T6078 T6077 acl possessing,proteins
R4201 T6079 T6081 det a,motif
R4202 T6126 T6089 punct .,p73
R4203 T6080 T6081 compound PPxY,motif
R4204 T6127 T6128 advmod Transiently,overexpressed
R4205 T6128 T6129 compound overexpressed,WWOX
R4206 T6081 T6078 dobj motif,possessing
R4207 T6129 T6130 nsubj WWOX,binds
R4208 T6130 T6130 ROOT binds,binds
R4209 T6082 T6081 punct (,motif
R421 T709 T710 compound WWOX,activation
R4210 T6131 T6132 compound transcription,factors
R4211 T6132 T6130 dobj factors,binds
R4212 T6133 T6132 appos AP-2,factors
R4213 T6083 T6081 appos s,motif
R4214 T6134 T6133 punct ",",AP-2
R4215 T6084 T6081 punct ),motif
R4216 T6135 T6133 appos p73,AP-2
R4217 T6136 T6133 punct ",",AP-2
R4218 T6085 T6086 amod such,as
R4219 T6137 T6133 cc and,AP-2
R422 T710 T708 dobj activation,triggering
R4220 T6138 T6133 conj c-Jun,AP-2
R4221 T6139 T6130 cc and,binds
R4222 T6140 T6130 conj block,binds
R4223 T6141 T6143 poss their,relocation
R4224 T6142 T6143 amod nuclear,relocation
R4225 T6086 T6078 prep as,possessing
R4226 T6143 T6140 dobj relocation,block
R4227 T6144 T6140 prep in,block
R4228 T6145 T6144 pobj vitro,in
R4229 T6087 T6086 pobj AP-2γ,as
R423 T711 T710 prep by,activation
R4230 T6146 T6145 punct ",",vitro
R4231 T6147 T6148 nsubj which,suppresses
R4232 T6148 T6145 relcl suppresses,vitro
R4233 T6088 T6087 punct ",",AP-2γ
R4234 T6149 T6150 compound cancer,cell
R4235 T6150 T6151 compound cell,survival
R4236 T6151 T6148 dobj survival,suppresses
R4237 T6089 T6087 conj p73,AP-2γ
R4238 T6152 T6155 punct (,al.
R4239 T6153 T6155 amod Salah,al.
R424 T712 T713 amod therapeutic,drugs
R4240 T6090 T6089 punct ",",p73
R4241 T6154 T6155 nmod et,al.
R4242 T6155 T6148 npadvmod al.,suppresses
R4243 T6156 T6155 punct ",",al.
R4244 T6091 T6089 conj ErbB4,p73
R4245 T6157 T6155 npadvmod 2012,al.
R4246 T6158 T6155 punct ),al.
R4247 T6092 T6091 punct ",",ErbB4
R4248 T6159 T6130 punct .,binds
R4249 T6160 T6165 prep In,co-migrates
R425 T713 T711 pobj drugs,by
R4250 T6161 T6162 amod stark,contrast
R4251 T6093 T6091 conj Ezrin,ErbB4
R4252 T6162 T6160 pobj contrast,In
R4253 T6163 T6165 punct ",",co-migrates
R4254 T6164 T6165 nsubj Wwox,co-migrates
R4255 T6094 T6093 punct ",",Ezrin
R4256 T6165 T6165 ROOT co-migrates,co-migrates
R4257 T6166 T6165 prep with,co-migrates
R4258 T6167 T6171 amod proapoptotic,factors
R4259 T6095 T6093 conj SIMPLE,Ezrin
R426 T715 T717 amod p53,deficiency
R4260 T6168 T6167 cc and,proapoptotic
R4261 T6169 T6167 conj pro-survival,proapoptotic
R4262 T6096 T6095 punct ",",SIMPLE
R4263 T6170 T6171 compound transcription,factors
R4264 T6171 T6166 pobj factors,with
R4265 T6172 T6165 prep to,co-migrates
R4266 T6173 T6174 det the,nuclei
R4267 T6097 T6095 conj c-Jun,SIMPLE
R4268 T6174 T6172 pobj nuclei,to
R4269 T6175 T6174 prep of,nuclei
R427 T716 T717 amod functional,deficiency
R4270 T6098 T6097 punct ",",c-Jun
R4271 T6176 T6175 pobj neurons,of
R4272 T6177 T6174 prep upon,nuclei
R4273 T6178 T6180 amod sciatic,axotomy
R4274 T6099 T6097 conj RUNX4,c-Jun
R4275 T6100 T6099 punct ",",RUNX4
R4276 T6179 T6180 compound nerve,axotomy
R4277 T6101 T6089 cc and,p73
R4278 T6180 T6177 pobj axotomy,upon
R4279 T6181 T6180 prep in,axotomy
R428 T717 T714 pobj deficiency,under
R4280 T6182 T6181 pobj rats,in
R4281 T6102 T6103 amod many,others
R4282 T6183 T6186 punct (,al.
R4283 T6184 T6186 compound Li,al.
R4284 T6185 T6186 nmod et,al.
R4285 T6103 T6089 conj others,p73
R4286 T6104 T6103 punct (,others
R4287 T6186 T6165 appos al.,co-migrates
R4288 T6105 T6107 compound Chang,al.
R4289 T6187 T6186 punct ",",al.
R429 T718 T719 auxpass is,needed
R4290 T6188 T6186 npadvmod 2009,al.
R4291 T6106 T6107 nmod et,al.
R4292 T6189 T6186 punct ),al.
R4293 T6190 T6165 punct .,co-migrates
R4294 T6107 T6103 appos al.,others
R4295 T6191 T6192 det No,blocking
R4296 T6192 T6204 nsubjpass blocking,observed
R4297 T6193 T6192 prep of,blocking
R4298 T6108 T6107 punct ",",al.
R4299 T6194 T6193 pobj translocation,of
R430 T719 T706 ccomp needed,propose
R4300 T6195 T6194 prep of,translocation
R4301 T6196 T6197 compound transcription,factors
R4302 T6109 T6107 npadvmod 2007,al.
R4303 T6197 T6195 pobj factors,of
R4304 T6198 T6192 prep to,blocking
R4305 T6199 T6200 det the,nuclei
R4306 T6110 T6107 punct ;,al.
R4307 T6200 T6198 pobj nuclei,to
R4308 T6201 T6192 prep by,blocking
R4309 T6202 T6201 pobj Wwox,by
R431 T720 T721 aux to,overcome
R4310 T6111 T6113 compound Salah,al.
R4311 T6203 T6204 auxpass was,observed
R4312 T6204 T6204 ROOT observed,observed
R4313 T6205 T6204 punct .,observed
R4314 T6112 T6113 nmod et,al.
R4315 T6206 T6212 prep Under,activated
R4316 T6207 T6208 compound stress,conditions
R4317 T6208 T6206 pobj conditions,Under
R4318 T6113 T6107 conj al.,al.
R4319 T6209 T6212 punct ",",activated
R432 T721 T719 advcl overcome,needed
R4320 T6210 T6212 nsubjpass WWOX,activated
R4321 T6114 T6113 punct ",",al.
R4322 T6211 T6212 auxpass is,activated
R4323 T6212 T6212 ROOT activated,activated
R4324 T6213 T6212 prep via,activated
R4325 T6214 T6213 pobj phosphorylation,via
R4326 T6215 T6212 prep at,activated
R4327 T6216 T6215 pobj Tyr33,at
R4328 T6115 T6113 appos 2012,al.
R4329 T6217 T6212 punct ",",activated
R433 T722 T723 compound TMZ,resistance
R4330 T6218 T6212 cc and,activated
R4331 T6219 T6212 conj binds,activated
R4332 T6116 T6103 punct ;,others
R4333 T6220 T6219 dobj proteins,binds
R4334 T6221 T6219 advmod independently,binds
R4335 T6222 T6221 prep of,independently
R4336 T6117 T6119 compound Su,al.
R4337 T6118 T6119 compound et,al.
R4338 T6119 T6103 conj al.,others
R4339 T6120 T6119 punct ",",al.
R434 T723 T721 dobj resistance,overcome
R4340 T6223 T6225 det the,motif
R4341 T6224 T6225 compound PPxY,motif
R4342 T6121 T6119 npadvmod 2012,al.
R4343 T6225 T6222 pobj motif,of
R4344 T6226 T6229 punct (,al.
R4345 T6227 T6229 compound Chang,al.
R4346 T6122 T6103 punct ;,others
R4347 T6228 T6229 nmod et,al.
R4348 T6229 T6219 parataxis al.,binds
R4349 T6230 T6229 punct ",",al.
R435 T724 T721 cc and,overcome
R4350 T6123 T6089 appos Figure,p73
R4351 T6231 T6229 npadvmod 2001,al.
R4352 T6232 T6231 punct ",",2001
R4353 T6233 T6231 conj 2003,2001
R4354 T6124 T6123 nummod 1,Figure
R4355 T6234 T6229 punct ",",al.
R4356 T6235 T6229 appos 2005a,al.
R4357 T6236 T6229 punct ",",al.
R4358 T6125 T6123 punct ),Figure
R4359 T6237 T6229 conj b,al.
R436 T725 T721 conj induce,overcome
R4360 T6238 T6237 punct ",",b
R4361 T6239 T6237 npadvmod 2007,b
R4362 T6320 T6322 nmod Bouteille,al.
R4363 T6240 T6239 punct ",",2007
R4364 T6241 T6239 conj 2010,2007
R4365 T6321 T6322 nmod et,al.
R4366 T6242 T6237 punct ),b
R4367 T6322 T6308 conj al.,Dvl-2
R4368 T6243 T6212 punct .,activated
R4369 T6244 T6245 compound Activated,WWOX
R437 T726 T728 compound GBM,death
R4370 T6245 T6247 nsubj WWOX,interacts
R4371 T6323 T6322 punct ",",al.
R4372 T6246 T6247 advmod physically,interacts
R4373 T6247 T6247 ROOT interacts,interacts
R4374 T6248 T6247 prep with,interacts
R4375 T6249 T6251 nmod serine,p53
R4376 T6324 T6322 pobj 2009,al.
R4377 T6250 T6251 amod 46-phosphorylated,p53
R4378 T6251 T6248 pobj p53,with
R4379 T6252 T6253 punct (,Figure
R438 T727 T728 compound cell,death
R4380 T6325 T6308 punct ),Dvl-2
R4381 T6253 T6251 appos Figure,p53
R4382 T6254 T6253 nummod 1,Figure
R4383 T6255 T6253 punct ),Figure
R4384 T6326 T6305 punct .,overexpressed
R4385 T6256 T6251 punct ",",p53
R4386 T6257 T6258 nsubj which,stabilizes
R4387 T6258 T6251 relcl stabilizes,p53
R4388 T6327 T6328 compound Overexpressed,WWOX
R4389 T6259 T6258 dobj p53,stabilizes
R439 T728 T725 dobj death,induce
R4390 T6328 T6329 nsubj WWOX,induces
R4391 T6260 T6259 cc and,p53
R4392 T6329 T6329 ROOT induces,induces
R4393 T6330 T6329 dobj apoptosis,induces
R4394 T6261 T6263 poss its,function
R4395 T6331 T6329 cc and,induces
R4396 T6262 T6263 amod apoptotic,function
R4397 T6332 T6329 conj inhibits,induces
R4398 T6263 T6259 conj function,p53
R4399 T6333 T6332 dobj proliferation,inhibits
R440 T729 T706 punct .,propose
R4400 T6334 T6333 prep of,proliferation
R4401 T6264 T6251 punct (,p53
R4402 T6265 T6267 compound Chang,al.
R4403 T6335 T6337 amod human,carcinoma
R4404 T6266 T6267 nmod et,al.
R4405 T6267 T6251 appos al.,p53
R4406 T6336 T6337 compound hepatic,carcinoma
R4407 T6268 T6267 punct ",",al.
R4408 T6269 T6267 appos 2005b,al.
R4409 T6270 T6251 punct ),p53
R4410 T6337 T6338 compound carcinoma,cells
R4411 T6271 T6247 punct .,interacts
R4412 T6272 T6275 advmod Also,binds
R4413 T6338 T6334 pobj cells,of
R4414 T6273 T6275 punct ",",binds
R4415 T6274 T6275 nsubj WWOX,binds
R4416 T6275 T6275 ROOT binds,binds
R4417 T6339 T6332 punct (,inhibits
R4418 T6276 T6277 amod Disheveled,proteins
R4419 T6277 T6275 dobj proteins,binds
R442 T617 T618 compound gene,expression
R4420 T6278 T6279 punct (,Dvl
R4421 T6340 T6342 compound Hu,al.
R4422 T6279 T6275 npadvmod Dvl,binds
R4423 T6280 T6279 punct ),Dvl
R4424 T6281 T6275 punct ",",binds
R4425 T6282 T6283 nsubj which,are
R4426 T6283 T6275 relcl are,binds
R4427 T6284 T6285 amod key,components
R4428 T6341 T6342 nmod et,al.
R4429 T6285 T6283 attr components,are
R443 T714 T710 prep under,activation
R4430 T6286 T6285 prep in,components
R4431 T6287 T6289 compound Wnt,β-catenin
R4432 T6342 T6332 appos al.,inhibits
R4433 T6288 T6289 compound /,β-catenin
R4434 T6289 T6291 compound β-catenin,pathway
R4435 T6290 T6291 compound signaling,pathway
R4436 T6343 T6342 punct ",",al.
R4437 T6291 T6286 pobj pathway,in
R4438 T6292 T6291 punct (,pathway
R4439 T6293 T6291 appos Figure,pathway
R4440 T6344 T6342 npadvmod 2012,al.
R4441 T6294 T6293 nummod 1,Figure
R4442 T6295 T6291 punct ),pathway
R4443 T6296 T6275 punct .,binds
R4444 T6297 T6299 det No,motif
R4445 T6345 T6332 punct ),inhibits
R4446 T6298 T6299 compound PPxY,motif
R4447 T6299 T6300 nsubj motif,is
R4448 T6300 T6300 ROOT is,is
R4449 T6301 T6300 prep in,is
R4450 T6346 T6332 cc and,inhibits
R4451 T6302 T6301 pobj Dvl,in
R4452 T6303 T6300 punct .,is
R4453 T6347 T6350 amod many,types
R4454 T6348 T6349 compound cancer,cell
R4455 T6304 T6305 advmod Transiently,overexpressed
R4456 T6349 T6350 compound cell,types
R4457 T6305 T6305 ROOT overexpressed,overexpressed
R4458 T6350 T6332 conj types,inhibits
R4459 T6306 T6307 compound WWOX,sequesters
R4460 T6307 T6308 compound sequesters,Dvl-2
R4461 T6351 T6332 punct (,inhibits
R4462 T6308 T6305 nsubjpass Dvl-2,overexpressed
R4463 T6309 T6308 prep in,Dvl-2
R4464 T6310 T6311 det the,cytoplasm
R4465 T6352 T6354 compound Chang,al.
R4466 T6311 T6309 pobj cytoplasm,in
R4467 T6312 T6309 cc and,in
R4468 T6353 T6354 nmod et,al.
R4469 T6313 T6314 advmod thereby,blocks
R4470 T6314 T6322 nmod blocks,al.
R4471 T6315 T6318 nmod Dvl-2-mediated,activity
R4472 T6316 T6318 nmod TCF,activity
R4473 T6354 T6332 appos al.,inhibits
R4474 T6317 T6318 amod transcriptional,activity
R4475 T6318 T6322 nmod activity,al.
R4476 T6319 T6322 punct (,al.
R4477 T6355 T6354 punct ",",al.
R4478 T6356 T6354 appos 2007,al.
R4479 T6417 T6414 conj stress,chemicals
R4480 T6357 T6356 punct ",",2007
R4481 T6418 T6417 punct ",",stress
R4482 T6419 T6420 amod such,as
R4483 T6358 T6356 conj 2010,2007
R4484 T6359 T6354 punct ;,al.
R4485 T6420 T6414 prep as,chemicals
R4486 T6360 T6362 compound Salah,al.
R4487 T6421 T6422 compound UV,irradiation
R4488 T6361 T6362 nmod et,al.
R4489 T6422 T6420 pobj irradiation,as
R4490 T6423 T6422 cc and,irradiation
R4491 T6424 T6425 amod chemotherapeutic,drugs
R4492 T6362 T6354 conj al.,al.
R4493 T6425 T6422 conj drugs,irradiation
R4494 T6426 T6428 punct ",",undergoes
R4495 T6363 T6362 punct ",",al.
R4496 T6427 T6428 nsubj WWOX,undergoes
R4497 T6428 T6428 ROOT undergoes,undergoes
R4498 T6429 T6428 dobj phosphorylation,undergoes
R4499 T6364 T6362 npadvmod 2012,al.
R4500 T6430 T6428 prep in,undergoes
R4501 T6365 T6332 punct ;,inhibits
R4502 T6431 T6430 pobj Tyr33,in
R4503 T6432 T6431 cc and,Tyr33
R4504 T6433 T6434 advmod probably,others
R4505 T6366 T6368 compound Su,al.
R4506 T6434 T6431 conj others,Tyr33
R4507 T6435 T6430 pobj sites,in
R4508 T6436 T6435 punct ",",sites
R4509 T6367 T6368 compound et,al.
R4510 T6437 T6435 acl followed,sites
R4511 T6438 T6437 agent by,followed
R4512 T6439 T6438 pcomp relocating,by
R4513 T6440 T6439 prep to,relocating
R4514 T6368 T6332 conj al.,inhibits
R4515 T6441 T6440 pobj mitochondria,to
R4516 T6442 T6441 cc or,mitochondria
R4517 T6369 T6368 punct ",",al.
R4518 T6443 T6441 conj nuclei,mitochondria
R4519 T6444 T6439 prep for,relocating
R4520 T6445 T6444 pcomp inducing,for
R4521 T6370 T6368 npadvmod 2012,al.
R4522 T6446 T6445 dobj apoptosis,inducing
R4523 T6447 T6450 punct (,al.
R4524 T6448 T6450 compound Chang,al.
R4525 T6449 T6450 nmod et,al.
R4526 T6450 T6450 ROOT al.,al.
R4527 T6451 T6450 punct ",",al.
R4528 T6371 T6368 punct ),al.
R4529 T6452 T6450 npadvmod 2007,al.
R4530 T6453 T6452 punct ",",2007
R4531 T6454 T6452 conj 2010,2007
R4532 T6455 T6450 punct ),al.
R4533 T6372 T6329 punct .,induces
R4534 T6456 T6450 punct .,al.
R4535 T6457 T6458 nsubj WWOX,binds
R4536 T6458 T6458 ROOT binds,binds
R4537 T6373 T6374 nsubj WWOX,enhances
R4538 T6459 T6458 dobj MEK,binds
R4539 T6460 T6458 prep in,binds
R4540 T6461 T6462 compound Jurkat,T
R4541 T6374 T6374 ROOT enhances,enhances
R4542 T6462 T6463 compound T,cells
R4543 T6463 T6460 pobj cells,in
R4544 T6375 T6377 det the,function
R4545 T6464 T6467 punct (,al.
R4546 T6465 T6467 compound Lin,al.
R4547 T6466 T6467 nmod et,al.
R4548 T6467 T6458 npadvmod al.,binds
R4549 T6376 T6377 amod cytotoxic,function
R4550 T6468 T6467 punct ",",al.
R4551 T6469 T6467 npadvmod 2011,al.
R4552 T6377 T6374 dobj function,enhances
R4553 T6378 T6377 prep of,function
R4554 T6379 T6380 compound tumor,necrosis
R4555 T6470 T6467 punct ),al.
R4556 T6471 T6458 punct .,binds
R4557 T6380 T6381 compound necrosis,factor
R4558 T6472 T6474 nmod Phorbol,acetate
R4559 T6473 T6474 compound myristate,acetate
R4560 T6381 T6378 pobj factor,of
R4561 T6474 T6478 nsubj acetate,dissociates
R4562 T6475 T6476 punct (,PMA
R4563 T6476 T6474 appos PMA,acetate
R4564 T6382 T6377 prep by,function
R4565 T6477 T6474 punct ),acetate
R4566 T6478 T6478 ROOT dissociates,dissociates
R4567 T6383 T6386 amod down-regulating,Bcl-2
R4568 T6479 T6481 det the,complex
R4569 T6480 T6481 compound MEK/WWOX,complex
R4570 T6481 T6478 dobj complex,dissociates
R4571 T6482 T6478 cc and,dissociates
R4572 T6384 T6385 compound apoptosis,inhibitor
R4573 T6483 T6478 conj induces,dissociates
R4574 T6484 T6483 dobj WWOX,induces
R4575 T6485 T6486 aux to,translocate
R4576 T6486 T6483 xcomp translocate,induces
R4577 T6487 T6486 prep to,translocate
R4578 T6488 T6489 det the,mitochondria
R4579 T6385 T6386 compound inhibitor,Bcl-2
R4580 T6489 T6487 pobj mitochondria,to
R4581 T6490 T6491 aux to,induce
R4582 T6491 T6486 advcl induce,translocate
R4583 T6386 T6382 pobj Bcl-2,by
R4584 T6492 T6491 dobj apoptosis,induce
R4585 T6493 T6483 punct ",",induces
R4586 T6494 T6496 mark whereas,relocates
R4587 T6495 T6496 nsubj MEK,relocates
R4588 T6387 T6386 cc and,Bcl-2
R4589 T6496 T6483 advcl relocates,induces
R4590 T6497 T6496 prep to,relocates
R4591 T6498 T6500 det the,raft
R4592 T6388 T6392 nmod Bcl-xL,p53
R4593 T6499 T6500 amod lipid,raft
R4594 T6389 T6388 cc and,Bcl-xL
R4595 T6390 T6388 conj up-regulating,Bcl-xL
R4596 T6500 T6497 pobj raft,to
R4597 T6391 T6392 amod apoptotic,p53
R4598 T6392 T6386 conj p53,Bcl-2
R4599 T6501 T6478 punct .,dissociates
R4600 T6502 T6506 nsubj Inhibition,increases
R4601 T6393 T6396 punct (,al.
R4602 T6503 T6502 prep of,Inhibition
R4603 T6504 T6505 compound MEK,activity
R4604 T6505 T6503 pobj activity,of
R4605 T6394 T6396 compound Chang,al.
R4606 T6506 T6506 ROOT increases,increases
R4607 T6507 T6508 amod TMZ-induced,suppression
R4608 T6508 T6506 dobj suppression,increases
R4609 T6395 T6396 nmod et,al.
R4610 T6509 T6508 prep of,suppression
R4611 T6510 T6511 compound cancer,cell
R4612 T6396 T6396 ROOT al.,al.
R4613 T6511 T6512 compound cell,growth
R4614 T6512 T6509 pobj growth,of
R4615 T6513 T6516 punct (,al.
R4616 T6397 T6396 punct ",",al.
R4617 T6398 T6396 npadvmod 2001,al.
R4618 T6399 T6396 punct ),al.
R4619 T6514 T6516 compound Holt,al.
R4620 T6400 T6396 punct .,al.
R4621 T6515 T6516 nmod et,al.
R4622 T6516 T6506 npadvmod al.,increases
R4623 T6401 T6404 advmod Also,mediates
R4624 T6517 T6516 punct ",",al.
R4625 T6518 T6516 npadvmod 2012,al.
R4626 T6519 T6516 punct ),al.
R4627 T6520 T6506 punct .,increases
R4628 T6521 T6522 amod Ectopic,expression
R4629 T6522 T6528 nsubj expression,induces
R4630 T6402 T6404 punct ",",mediates
R4631 T6523 T6522 prep of,expression
R4632 T6524 T6523 pobj WWOX,of
R4633 T6525 T6522 prep in,expression
R4634 T6403 T6404 nsubj WWOX,mediates
R4635 T6526 T6527 compound A549,cells
R4636 T6527 T6525 pobj cells,in
R4637 T6528 T6528 ROOT induces,induces
R4638 T6404 T6404 ROOT mediates,mediates
R4639 T6529 T6532 amod procaspase-3,activation
R4640 T6530 T6529 cc and,procaspase-3
R4641 T6405 T6406 compound cell,death
R4642 T6531 T6529 conj procaspase-9,procaspase-3
R4643 T6532 T6528 dobj activation,induces
R4644 T6533 T6528 cc and,induces
R4645 T6406 T6404 dobj death,mediates
R4646 T6534 T6528 conj induces,induces
R4647 T6535 T6536 compound cytochrome,C
R4648 T6536 T6534 dobj C,induces
R4649 T6537 T6534 advcl releasing,induces
R4650 T6407 T6404 advmod synergistically,mediates
R4651 T6538 T6537 prep from,releasing
R4652 T6539 T6540 det the,mitochondria
R4653 T6408 T6404 prep with,mediates
R4654 T6540 T6538 pobj mitochondria,from
R4655 T6541 T6540 punct (,mitochondria
R4656 T6542 T6544 compound Zhang,al.
R4657 T6409 T6408 pobj p53,with
R4658 T6543 T6544 nmod et,al.
R4659 T6544 T6540 appos al.,mitochondria
R4660 T6545 T6540 punct ",",mitochondria
R4661 T6410 T6404 punct .,mediates
R4662 T6546 T6540 amod 2012a,mitochondria
R4663 T6547 T6534 punct ),induces
R4664 T6411 T6428 prep Upon,undergoes
R4665 T6548 T6528 punct .,induces
R4666 T6549 T6550 compound Complement,C1q
R4667 T6550 T6551 nsubj C1q,induces
R4668 T6412 T6411 pobj exposure,Upon
R4669 T6551 T6551 ROOT induces,induces
R4670 T6552 T6554 amod ectopic,phosphorylation
R4671 T6413 T6412 prep to,exposure
R4672 T6553 T6554 compound WWOX,phosphorylation
R4673 T6554 T6551 dobj phosphorylation,induces
R4674 T6414 T6413 pobj chemicals,to
R4675 T6555 T6554 prep in,phosphorylation
R4676 T6556 T6555 pobj Try33,in
R4677 T6557 T6551 cc and,induces
R4678 T6558 T6551 conj leads,induces
R4679 T6559 T6558 prep to,leads
R4680 T6415 T6414 cc or,chemicals
R4681 T6560 T6561 compound cell,apoptosis
R4682 T6561 T6559 pobj apoptosis,to
R4683 T6416 T6417 amod environmental,stress
R4684 T6562 T6561 advmod independently,apoptosis
R4685 T6563 T6561 prep of,apoptosis
R4686 T6564 T6568 det the,pathway
R4687 T6611 T6609 dobj factor,Transforming
R4688 T6565 T6568 amod classical,pathway
R4689 T6566 T6568 compound complement,pathway
R4690 T6567 T6568 compound activation,pathway
R4691 T6568 T6563 pobj pathway,of
R4692 T6612 T6613 nummod β1,binds
R4693 T6569 T6572 punct (,al.
R4694 T6570 T6572 nmod Hong,al.
R4695 T6571 T6572 nmod et,al.
R4696 T6613 T6609 nsubj binds,Transforming
R4697 T6572 T6561 appos al.,apoptosis
R4698 T6573 T6572 punct ",",al.
R4699 T6574 T6572 npadvmod 2009,al.
R4700 T6614 T6613 dobj Hyal-2,binds
R4701 T6575 T6558 punct ),leads
R4702 T6576 T6551 punct .,induces
R4703 T6577 T6578 det A,portion
R4704 T6578 T6582 nsubjpass portion,anchored
R4705 T6615 T6614 prep as,Hyal-2
R4706 T6579 T6578 prep of,portion
R4707 T6616 T6618 det a,receptor
R4708 T6580 T6579 pobj WWOX,of
R4709 T6617 T6618 compound cognate,receptor
R4710 T6618 T6615 pobj receptor,as
R4711 T6581 T6582 auxpass is,anchored
R4712 T6582 T6582 ROOT anchored,anchored
R4713 T6619 T6620 aux to,signal
R4714 T6583 T6582 prep in,anchored
R4715 T6584 T6586 det the,area
R4716 T6620 T6613 advcl signal,binds
R4717 T6585 T6586 amod membrane/cytoskeleton,area
R4718 T6586 T6583 pobj area,in
R4719 T6587 T6582 prep via,anchored
R4720 T6621 T6622 det the,formation
R4721 T6588 T6587 amod binding,via
R4722 T6589 T6588 prep with,binding
R4723 T6622 T6620 dobj formation,signal
R4724 T6590 T6591 compound hyaluronidase,Hyal-2
R4725 T6591 T6589 pobj Hyal-2,with
R4726 T6592 T6595 punct (,al.
R4727 T6593 T6595 compound Hsu,al.
R4728 T6594 T6595 nmod et,al.
R4729 T6595 T6591 appos al.,Hyal-2
R4730 T6623 T6622 prep of,formation
R4731 T6596 T6595 punct ",",al.
R4732 T6597 T6595 npadvmod 2009,al.
R4733 T6624 T6629 det the,complex
R4734 T6598 T6595 punct ),al.
R4735 T6599 T6591 cc and,Hyal-2
R4736 T6600 T6591 conj Phospho-Ezrin,Hyal-2
R4737 T6625 T6628 compound WWOX/Hyal,Smad4
R4738 T6601 T6604 punct (,al.
R4739 T6602 T6604 compound Jin,al.
R4740 T6603 T6604 nmod et,al.
R4741 T6626 T6627 compound -2,/
R4742 T6604 T6600 parataxis al.,Phospho-Ezrin
R4743 T6605 T6604 punct ",",al.
R4744 T6606 T6604 npadvmod 2006,al.
R4745 T6627 T6628 compound /,Smad4
R4746 T6607 T6604 punct ),al.
R4747 T6608 T6582 punct .,anchored
R4748 T6609 T6609 ROOT Transforming,Transforming
R4749 T6628 T6629 compound Smad4,complex
R4750 T6610 T6611 compound growth,factor
R4751 T6629 T6623 pobj complex,of
R4752 T6630 T6631 aux to,relocate
R4753 T6631 T6620 xcomp relocate,signal
R4754 T6632 T6631 prep to,relocate
R4755 T6633 T6634 det the,nucleus
R4756 T6634 T6632 pobj nucleus,to
R4757 T6635 T6634 prep for,nucleus
R4758 T6636 T6635 pcomp enhancing,for
R4759 T6637 T6640 det the,activity
R4760 T6638 T6640 amod SMAD-driven,activity
R4761 T6639 T6640 compound promoter,activity
R4762 T6640 T6636 dobj activity,enhancing
R4763 T6641 T6644 punct (,al.
R4764 T6642 T6644 compound Hsu,al.
R4765 T6643 T6644 nmod et,al.
R4766 T6644 T6613 dep al.,binds
R4767 T6645 T6644 punct ",",al.
R4768 T6646 T6644 npadvmod 2009,al.
R4769 T6647 T6644 punct ),al.
R4770 T6648 T6609 punct .,Transforming
R5005 T7155 T7158 amod Activated,apoptosis
R5006 T7156 T7158 nmod p53,apoptosis
R5007 T7157 T7158 compound mediates,apoptosis
R5008 T7158 T7158 ROOT apoptosis,apoptosis
R5009 T7159 T7162 punct ",",arrest
R5010 T7160 T7161 compound cell,cycle
R5011 T7161 T7162 compound cycle,arrest
R5012 T7162 T7158 appos arrest,apoptosis
R5013 T7163 T7162 punct ",",arrest
R5014 T7164 T7162 appos senescence,arrest
R5015 T7165 T7162 punct ",",arrest
R5016 T7166 T7167 compound DNA,repair
R5017 T7167 T7162 appos repair,arrest
R5018 T7168 T7167 punct ",",repair
R5019 T7169 T7167 cc or,repair
R5020 T7170 T7167 conj metabolism,repair
R5021 T7171 T7167 punct (,repair
R5022 T7172 T7167 appos Lane,repair
R5023 T7173 T7172 cc and,Lane
R5024 T7174 T7172 conj Levine,Lane
R5025 T7175 T7174 punct ",",Levine
R5026 T7176 T7174 npadvmod 2010,Levine
R5027 T7177 T7174 punct ),Levine
R5028 T7178 T7162 punct .,arrest
R5029 T7179 T7181 det The,structures
R5030 T7180 T7181 amod primary,structures
R5031 T7181 T7188 nsubjpass structures,depicted
R5032 T7182 T7181 prep of,structures
R5033 T7183 T7182 pobj p53,of
R5034 T7184 T7183 cc and,p53
R5035 T7185 T7186 poss its,isoforms
R5036 T7186 T7188 nsubjpass isoforms,depicted
R5037 T7187 T7188 auxpass are,depicted
R5038 T7188 T7188 ROOT depicted,depicted
R5039 T7189 T7190 punct (,Figure
R5040 T7190 T7188 oprd Figure,depicted
R5041 T7191 T7190 nummod 2,Figure
R5042 T7192 T7190 punct ),Figure
R5043 T7193 T7188 punct .,depicted
R5044 T7194 T7195 nsubj p53,induces
R5045 T7195 T7195 ROOT induces,induces
R5046 T7196 T7197 compound cell,cycle
R5047 T7197 T7198 compound cycle,arrest
R5048 T7198 T7195 dobj arrest,induces
R5049 T7199 T7195 prep by,induces
R5050 T7200 T7199 pcomp transactivating,by
R5051 T7201 T7200 dobj genes,transactivating
R5052 T7202 T7203 amod such,as
R5053 T7203 T7201 prep as,genes
R5054 T7204 T7206 amod cyclin-dependent,inhibitor
R5055 T7205 T7206 compound kinase,inhibitor
R5056 T7206 T7203 pobj inhibitor,as
R5057 T7207 T7206 nummod p21,inhibitor
R5058 T7208 T7207 punct ",",p21
R5059 T7209 T7206 cc or,inhibitor
R5060 T7210 T7211 compound microRNA,miR34
R5061 T7211 T7206 conj miR34,inhibitor
R5062 T7212 T7195 punct .,induces
R5063 T7213 T7214 nsubj p53,induces
R5064 T7214 T7214 ROOT induces,induces
R5065 T7215 T7214 dobj apoptosis,induces
R5066 T7216 T7214 prep by,induces
R5067 T7217 T7216 pcomp transactivating,by
R5068 T7218 T7219 amod proapoptotic,genes
R5069 T7219 T7217 dobj genes,transactivating
R5070 T7220 T7221 amod such,as
R5071 T7221 T7219 prep as,genes
R5072 T7222 T7221 pobj BAX,as
R5073 T7223 T7222 punct ",",BAX
R5074 T7224 T7222 conj PUMA,BAX
R5075 T7225 T7224 punct ",",PUMA
R5076 T7226 T7224 conj SCOTIN,PUMA
R5077 T7227 T7226 punct ",",SCOTIN
R5078 T7228 T7226 cc and,SCOTIN
R5079 T7229 T7226 conj FAS,SCOTIN
R5080 T7230 T7229 punct ",",FAS
R5081 T7231 T7217 cc and,transactivating
R5082 T7232 T7217 conj inhibiting,transactivating
R5083 T7233 T7236 det the,BCL-2
R5084 T7234 T7235 amod antiapoptotic,gene
R5085 T7235 T7236 compound gene,BCL-2
R5086 T7236 T7232 dobj BCL-2,inhibiting
R5087 T7237 T7236 punct (,BCL-2
R5088 T7238 T7236 appos Lane,BCL-2
R5089 T7239 T7238 cc and,Lane
R5090 T7240 T7238 conj Levine,Lane
R5091 T7241 T7240 punct ",",Levine
R5092 T7242 T7240 npadvmod 2010,Levine
R5093 T7243 T7240 punct ),Levine
R5094 T7244 T7214 punct .,induces
R5095 T7245 T7246 nsubj p53,triggers
R5096 T7246 T7246 ROOT triggers,triggers
R5097 T7247 T7251 amod pro-survival,response
R5098 T7248 T7247 cc or,pro-survival
R5099 T7249 T7247 conj cell,pro-survival
R5100 T7250 T7251 compound death,response
R5101 T7251 T7246 dobj response,triggers
R5102 T7252 T7246 punct ",",triggers
R5103 T7253 T7246 advcl depending,triggers
R5104 T7254 T7253 prep upon,depending
R5105 T7255 T7256 compound cell,types
R5106 T7256 T7254 pobj types,upon
R5107 T7257 T7253 punct ",",depending
R5108 T7258 T7259 det the,intensity
R5109 T7259 T7246 dobj intensity,triggers
R5110 T7260 T7259 prep of,intensity
R5111 T7261 T7263 det the,signal
R5112 T7262 T7263 compound stress,signal
R5113 T7263 T7260 pobj signal,of
R5114 T7264 T7259 punct ",",intensity
R5115 T7265 T7259 cc and,intensity
R5116 T7266 T7267 det the,extent
R5117 T7267 T7259 conj extent,intensity
R5118 T7268 T7267 prep of,extent
R5119 T7269 T7270 amod cellular,damage
R5120 T7270 T7268 pobj damage,of
R5121 T7271 T7274 punct (,al.
R5122 T7272 T7274 compound Menendez,al.
R5123 T7273 T7274 nmod et,al.
R5124 T7274 T7267 conj al.,extent
R5125 T7275 T7274 punct ",",al.
R5126 T7276 T7274 npadvmod 2009,al.
R5127 T7277 T7274 punct ),al.
R5128 T7278 T7246 punct .,triggers
R5129 T7279 T7282 advmod Also,plays
R5130 T7280 T7282 punct ",",plays
R5131 T7281 T7282 nsubj p53,plays
R5132 T7282 T7282 ROOT plays,plays
R5133 T7283 T7284 det a,role
R5134 T7284 T7282 dobj role,plays
R5135 T7285 T7284 prep in,role
R5136 T7286 T7285 pcomp controlling,in
R5137 T7287 T7288 compound cell,motility
R5138 T7288 T7286 dobj motility,controlling
R5139 T7289 T7286 prep via,controlling
R5140 T7290 T7289 pcomp regulating,via
R5141 T7291 T7292 det the,expression
R5142 T7292 T7290 dobj expression,regulating
R5143 T7293 T7292 prep of,expression
R5144 T7294 T7296 amod smooth,α-actin
R5145 T7295 T7296 compound muscle,α-actin
R5146 T7296 T7293 pobj α-actin,of
R5147 T7297 T7300 punct (,al.
R5148 T7298 T7300 compound Comer,al.
R5149 T7299 T7300 nmod et,al.
R5150 T7300 T7292 appos al.,expression
R5151 T7301 T7300 punct ",",al.
R5152 T7302 T7300 npadvmod 1998,al.
R5153 T7303 T7292 punct ),expression
R5154 T7304 T7282 punct ",",plays
R5155 T7305 T7282 conj collagens,plays
R5156 T7306 T7305 dobj IIα1,collagens
R5157 T7307 T7306 cc and,IIα1
R5158 T7308 T7306 conj VIα1,IIα1
R5159 T7309 T7312 punct (,al.
R5160 T7310 T7312 compound Sun,al.
R5161 T7311 T7312 nmod et,al.
R5162 T7312 T7308 parataxis al.,VIα1
R5163 T7313 T7312 punct ",",al.
R5164 T7314 T7312 npadvmod 1999,al.
R5165 T7315 T7312 punct ),al.
R5166 T7316 T7312 punct ",",al.
R5167 T7317 T7312 cc and,al.
R5168 T7318 T7319 amod many,others
R5169 T7319 T7312 conj others,al.
R5170 T7320 T7282 punct .,plays
R5527 T7989 T7990 advmod At,least
R5528 T7990 T7991 advmod least,nine
R5529 T7991 T7992 nummod nine,isoforms
R5530 T7992 T7997 nsubjpass isoforms,identified
R5531 T7993 T7992 prep of,isoforms
R5532 T7994 T7993 pobj p53,of
R5533 T7995 T7997 aux have,identified
R5534 T7996 T7997 auxpass been,identified
R5535 T7997 T7997 ROOT identified,identified
R5536 T7998 T8002 amod due,splicing
R5537 T7999 T8000 aux to,alternative
R5538 T8000 T7998 xcomp alternative,due
R5539 T8001 T8002 compound mRNA,splicing
R5540 T8002 T7997 dobj splicing,identified
R5541 T8003 T8002 punct ",",splicing
R5542 T8004 T8006 amod multiple,promoters
R5543 T8005 T8006 compound gene,promoters
R5544 T8006 T8002 conj promoters,splicing
R5545 T8007 T8006 punct ",",promoters
R5546 T8008 T8006 cc and,promoters
R5547 T8009 T8011 amod alternative,sites
R5548 T8010 T8011 compound initiation,sites
R5549 T8011 T8006 conj sites,promoters
R5550 T8012 T8011 prep of,sites
R5551 T8013 T8012 pobj translation,of
R5552 T8014 T8002 punct (,splicing
R5553 T8015 T8017 compound Ghosh,al.
R5554 T8016 T8017 nmod et,al.
R5555 T8017 T8002 appos al.,splicing
R5556 T8018 T8017 punct ",",al.
R5557 T8019 T8017 appos 2004,al.
R5558 T8020 T8002 punct ;,splicing
R5559 T8021 T8023 compound Ray,al.
R5560 T8022 T8023 nmod et,al.
R5561 T8023 T8002 conj al.,splicing
R5562 T8024 T8023 punct ",",al.
R5563 T8025 T8023 appos 2006,al.
R5564 T8026 T8023 punct ;,al.
R5565 T8027 T8023 appos Figure,al.
R5566 T8028 T8027 nummod 2,Figure
R5567 T8029 T8023 punct ),al.
R5568 T8030 T7997 punct .,identified
R5569 T8031 T8039 prep In,occurs
R5570 T8032 T8031 pobj cancers,In
R5571 T8033 T8035 punct ",",expression
R5572 T8034 T8035 amod aberrant,expression
R5573 T8035 T8039 nsubj expression,occurs
R5574 T8036 T8035 prep of,expression
R5575 T8037 T8038 compound p53,isoforms
R5576 T8038 T8036 pobj isoforms,of
R5577 T8039 T8039 ROOT occurs,occurs
R5578 T8040 T8039 advmod frequently,occurs
R5579 T8041 T8044 punct (,al.
R5580 T8042 T8044 nmod Bourdon,al.
R5581 T8043 T8044 nmod et,al.
R5582 T8044 T8039 parataxis al.,occurs
R5583 T8045 T8044 punct ",",al.
R5584 T8046 T8044 npadvmod 2005,al.
R5585 T8047 T8048 punct ;,Bourdon
R5586 T8048 T8039 nsubj Bourdon,occurs
R5587 T8049 T8048 punct ",",Bourdon
R5588 T8050 T8048 npadvmod 2007,Bourdon
R5589 T8051 T8048 punct ),Bourdon
R5590 T8052 T8039 punct .,occurs
R5591 T8053 T8054 amod Full-length,p53
R5592 T8054 T8061 nsubjpass p53,localized
R5593 T8055 T8054 punct ",",p53
R5594 T8056 T8054 conj Δ133p53,p53
R5595 T8057 T8056 punct ",",Δ133p53
R5596 T8058 T8056 cc and,Δ133p53
R5597 T8059 T8056 conj p53β,Δ133p53
R5598 T8060 T8061 auxpass are,localized
R5599 T8061 T8061 ROOT localized,localized
R5600 T8062 T8063 advmod mainly,in
R5601 T8063 T8061 prep in,localized
R5602 T8064 T8065 det the,nucleus
R5603 T8065 T8063 pobj nucleus,in
R5604 T8066 T8061 punct ",",localized
R5605 T8067 T8061 cc and,localized
R5606 T8068 T8069 advmod only,few
R5607 T8069 T8072 nsubj few,are
R5608 T8070 T8069 prep of,few
R5609 T8071 T8070 pobj them,of
R5610 T8072 T8061 conj are,localized
R5611 T8073 T8072 prep in,are
R5612 T8074 T8073 pobj cytoplasm,in
R5613 T8075 T8072 punct .,are
R5614 T8076 T8080 nsubjpass p53γ,localized
R5615 T8077 T8076 cc and,p53γ
R5616 T8078 T8076 conj Δ133p53β,p53γ
R5617 T8079 T8080 auxpass are,localized
R5618 T8080 T8080 ROOT localized,localized
R5619 T8081 T8080 prep in,localized
R5620 T8082 T8083 det the,nucleus
R5621 T8083 T8081 pobj nucleus,in
R5622 T8084 T8083 cc and,nucleus
R5623 T8085 T8083 conj cytoplasm,nucleus
R5624 T8086 T8080 punct .,localized
R5625 T8087 T8089 nsubjpass Δ133p53γ,localized
R5626 T8088 T8089 auxpass is,localized
R5627 T8089 T8089 ROOT localized,localized
R5628 T8090 T8089 prep in,localized
R5629 T8091 T8092 det the,cytoplasm
R5630 T8092 T8090 pobj cytoplasm,in
R5631 T8093 T8096 punct (,al.
R5632 T8094 T8096 compound Bourdon,al.
R5633 T8095 T8096 nmod et,al.
R5634 T8096 T8089 npadvmod al.,localized
R5635 T8097 T8096 punct ",",al.
R5636 T8098 T8096 npadvmod 2005,al.
R5637 T8099 T8096 punct ),al.
R5638 T8100 T8089 punct .,localized
R5639 T8101 T8106 nmod Co-transfection,increases
R5640 T8102 T8101 prep of,Co-transfection
R5641 T8103 T8102 pobj p53,of
R5642 T8104 T8103 cc and,p53
R5643 T8105 T8106 amod p53β,increases
R5644 T8106 T8106 ROOT increases,increases
R5645 T8107 T8108 compound p53-mediated,apoptosis
R5646 T8108 T8106 dobj apoptosis,increases
R5647 T8109 T8106 punct ",",increases
R5648 T8110 T8122 nmod whereas,al.
R5649 T8111 T8122 dep co-expression,al.
R5650 T8112 T8111 prep of,co-expression
R5651 T8113 T8112 pobj p53,of
R5652 T8114 T8111 prep with,co-expression
R5653 T8115 T8116 amod Δ133p53,suppresses
R5654 T8116 T8114 pobj suppresses,with
R5655 T8117 T8118 nmod p53-mediated,apoptosis
R5656 T8118 T8111 conj apoptosis,co-expression
R5657 T8119 T8122 punct (,al.
R5658 T8120 T8122 compound Bourdon,al.
R5659 T8121 T8122 nmod et,al.
R5660 T8122 T8106 advcl al.,increases
R5661 T8123 T8122 punct ",",al.
R5662 T8124 T8122 npadvmod 2005,al.
R5663 T8125 T8122 punct ),al.
R5664 T8126 T8106 punct .,increases
R5665 T8127 T8129 nsubj Δ133p53,regulates
R5666 T8128 T8129 advmod differentially,regulates
R5667 T8129 T8129 ROOT regulates,regulates
R5668 T8130 T8131 compound gene,expression
R5669 T8131 T8129 dobj expression,regulates
R5670 T8132 T8131 prep in,expression
R5671 T8133 T8132 pobj p53-dependent,in
R5672 T8134 T8129 cc and,regulates
R5673 T8135 T8129 punct -,regulates
R5674 T8136 T8137 amod independent,manners
R5675 T8137 T8129 conj manners,regulates
R5676 T8138 T8137 punct (,manners
R5677 T8139 T8141 compound Aoubala,al.
R5678 T8140 T8141 nmod et,al.
R5679 T8141 T8137 appos al.,manners
R5680 T8142 T8141 punct ",",al.
R5681 T8143 T8141 npadvmod 2011,al.
R5682 T8144 T8137 punct ),manners
R5683 T8145 T8129 punct .,regulates
R5684 T8146 T8155 nsubj Co-expression,affect
R5685 T8147 T8146 prep of,Co-expression
R5686 T8148 T8147 pobj Δ133p53β,of
R5687 T8149 T8148 cc or,Δ133p53β
R5688 T8150 T8148 conj Δ133p53γ,Δ133p53β
R5689 T8151 T8146 prep with,Co-expression
R5690 T8152 T8151 pobj p53,with
R5691 T8153 T8155 aux does,affect
R5692 T8154 T8155 neg not,affect
R5693 T8155 T8155 ROOT affect,affect
R5694 T8156 T8158 nmod p53,activity
R5695 T8157 T8158 compound transcriptional,activity
R5696 T8158 T8155 dobj activity,affect
R5697 T8159 T8158 prep on,activity
R5698 T8160 T8159 pobj p21,on
R5699 T8161 T8155 cc and,affect
R5700 T8162 T8163 compound Bax,promoters
R5701 T8163 T8163 ROOT promoters,promoters
R5702 T8164 T8163 punct ",",promoters
R5703 T8165 T8167 advmod as,as
R5704 T8166 T8167 advmod well,as
R5705 T8167 T8163 cc as,promoters
R5706 T8168 T8163 conj apoptosis,promoters
R5707 T8169 T8155 punct .,affect
R6238 T9180 T9181 compound p53,mutants
R6239 T9181 T9183 nsubjpass mutants,considered
R6240 T9182 T9183 auxpass are,considered
R6241 T9183 T9219 ccomp considered,al.
R6242 T9184 T9183 prep as,considered
R6243 T9185 T9186 amod unfavorable,factors
R6244 T9186 T9184 pobj factors,as
R6245 T9187 T9186 prep for,factors
R6246 T9188 T9189 det the,effectiveness
R6247 T9189 T9187 pobj effectiveness,for
R6248 T9190 T9189 prep in,effectiveness
R6249 T9191 T9194 amod radiotherapy,treatment
R6250 T9192 T9191 cc and,radiotherapy
R6251 T9193 T9194 compound TMZ,treatment
R6252 T9194 T9190 pobj treatment,in
R6253 T9195 T9189 prep in,effectiveness
R6254 T9196 T9197 compound glioma,cells
R6255 T9197 T9195 pobj cells,in
R6256 T9198 T9201 punct (,al.
R6257 T9199 T9201 nmod Gjerset,al.
R6258 T9200 T9201 nmod et,al.
R6259 T9201 T9186 appos al.,factors
R6260 T9202 T9201 punct ",",al.
R6261 T9203 T9201 npadvmod 1995,al.
R6262 T9204 T9219 punct ;,al.
R6263 T9205 T9207 compound Hirose,al.
R6264 T9206 T9207 nmod et,al.
R6265 T9207 T9219 ccomp al.,al.
R6266 T9208 T9207 punct ",",al.
R6267 T9209 T9207 npadvmod 2001,al.
R6268 T9210 T9219 punct ;,al.
R6269 T9211 T9213 compound Squatrito,al.
R6270 T9212 T9213 compound et,al.
R6271 T9213 T9219 ccomp al.,al.
R6272 T9214 T9213 punct ",",al.
R6273 T9215 T9213 npadvmod 2010,al.
R6274 T9216 T9219 punct ;,al.
R6275 T9217 T9219 compound Blough,al.
R6276 T9218 T9219 compound et,al.
R6277 T9219 T9219 ROOT al.,al.
R6278 T9220 T9219 punct ",",al.
R6279 T9221 T9219 npadvmod 2011,al.
R6280 T9222 T9219 punct ),al.
R6281 T9223 T9219 punct .,al.
R6282 T9224 T9228 nsubj Loss,confers
R6283 T9225 T9224 prep of,Loss
R6284 T9226 T9227 amod functional,p53
R6285 T9227 T9225 pobj p53,of
R6286 T9228 T9228 ROOT confers,confers
R6287 T9229 T9228 dobj sensitivity,confers
R6288 T9230 T9229 prep to,sensitivity
R6289 T9231 T9230 pobj TMZ,to
R6290 T9232 T9228 prep in,confers
R6291 T9233 T9234 amod glioma,cells
R6292 T9234 T9232 pobj cells,in
R6293 T9235 T9228 punct ",",confers
R6294 T9236 T9240 mark whereas,increases
R6295 T9237 T9239 amod wild,p53
R6296 T9238 T9239 compound type,p53
R6297 T9239 T9240 nsubj p53,increases
R6298 T9240 T9228 advcl increases,confers
R6299 T9241 T9243 det the,resistance
R6300 T9242 T9243 compound TMZ,resistance
R6301 T9243 T9240 dobj resistance,increases
R6302 T9244 T9240 punct (,increases
R6303 T9245 T9247 amod Blough,al.
R6304 T9246 T9247 nmod et,al.
R6305 T9247 T9240 npadvmod al.,increases
R6306 T9248 T9247 punct ",",al.
R6307 T9249 T9247 npadvmod 2011,al.
R6308 T9250 T9240 punct ),increases
R6309 T9251 T9228 punct .,confers
R6310 T9252 T9253 compound p53,mutants
R6311 T9253 T9254 nsubj mutants,reduce
R6312 T9254 T9254 ROOT reduce,reduce
R6313 T9255 T9256 compound TMZ,sensitivity
R6314 T9256 T9254 dobj sensitivity,reduce
R6315 T9257 T9256 prep in,sensitivity
R6316 T9258 T9257 pobj gliomas,in
R6317 T9259 T9262 punct (,al.
R6318 T9260 T9262 amod Blough,al.
R6319 T9261 T9262 nmod et,al.
R6320 T9262 T9254 advmod al.,reduce
R6321 T9263 T9262 punct ",",al.
R6322 T9264 T9262 npadvmod 2011,al.
R6323 T9265 T9262 punct ),al.
R6324 T9266 T9254 punct .,reduce
R6325 T9267 T9269 amod Altered,expression
R6326 T9268 T9269 compound WWOX,expression
R6327 T9269 T9271 nsubjpass expression,shown
R6328 T9270 T9271 auxpass is,shown
R6329 T9271 T9271 ROOT shown,shown
R6330 T9272 T9271 prep in,shown
R6331 T9273 T9272 pobj GBMs,in
R6332 T9274 T9273 punct ",",GBMs
R6333 T9275 T9281 prep in,associated
R6334 T9276 T9275 pobj which,in
R6335 T9277 T9281 nsubjpass downregulation,associated
R6336 T9278 T9277 prep of,downregulation
R6337 T9279 T9278 pobj WWOX,of
R6338 T9280 T9281 auxpass is,associated
R6339 T9281 T9271 conj associated,shown
R6340 T9282 T9281 prep with,associated
R6341 T9283 T9282 pobj loss,with
R6342 T9284 T9283 prep of,loss
R6343 T9285 T9284 pobj heterozygosity,of
R6344 T9286 T9285 cc and,heterozygosity
R6345 T9287 T9288 compound promoter,methylation
R6346 T9288 T9285 conj methylation,heterozygosity
R6347 T9289 T9292 punct (,al.
R6348 T9290 T9292 compound Kosla,al.
R6349 T9291 T9292 nmod et,al.
R6350 T9292 T9283 appos al.,loss
R6351 T9293 T9292 punct ",",al.
R6352 T9294 T9292 npadvmod 2011,al.
R6353 T9295 T9281 punct ),associated
R6354 T9296 T9271 punct .,shown
R6355 T9297 T9300 advmod Recently,demonstrated
R6356 T9298 T9300 punct ",",demonstrated
R6357 T9299 T9300 nsubj we,demonstrated
R6358 T9300 T9300 ROOT demonstrated,demonstrated
R6359 T9301 T9304 mark that,induces
R6360 T9302 T9303 compound overexpressed,WWOX
R6361 T9303 T9304 nsubj WWOX,induces
R6362 T9304 T9300 ccomp induces,demonstrated
R6363 T9305 T9304 dobj apoptosis,induces
R6364 T9306 T9305 prep of,apoptosis
R6365 T9307 T9309 amod glioblastoma,cells
R6366 T9308 T9309 compound U373-MG,cells
R6367 T9309 T9306 pobj cells,of
R6368 T9310 T9309 acl harboring,cells
R6369 T9311 T9312 amod mutant,p53
R6370 T9312 T9310 dobj p53,harboring
R6371 T9313 T9310 prep by,harboring
R6372 T9314 T9313 pcomp causing,by
R6373 T9315 T9318 amod hypoploidy,fragmentation
R6374 T9316 T9315 cc and,hypoploidy
R6375 T9317 T9315 conj DNA,hypoploidy
R6376 T9318 T9314 dobj fragmentation,causing
R6377 T9319 T9322 punct (,al.
R6378 T9320 T9322 compound Chiang,al.
R6379 T9321 T9322 nmod et,al.
R6380 T9322 T9314 ccomp al.,causing
R6381 T9323 T9322 punct ",",al.
R6382 T9324 T9322 npadvmod 2012,al.
R6383 T9325 T9322 punct ),al.
R6384 T9326 T9300 punct .,demonstrated
R6385 T9327 T9331 advmod However,has
R6386 T9328 T9331 punct ",",has
R6387 T9329 T9330 compound ectopic,WWOX
R6388 T9330 T9331 nsubj WWOX,has
R6389 T9331 T9331 ROOT has,has
R6390 T9332 T9333 det no,effect
R6391 T9333 T9331 dobj effect,has
R6392 T9334 T9333 prep with,effect
R6393 T9335 T9336 nsubj U87-MG,expressing
R6394 T9336 T9334 pcomp expressing,with
R6395 T9337 T9339 amod wild,p53
R6396 T9338 T9339 compound type,p53
R6397 T9339 T9336 dobj p53,expressing
R6398 T9340 T9331 punct .,has
R6399 T9341 T9345 prep Unlike,induces
R6400 T9342 T9341 pobj TMZ,Unlike
R6401 T9343 T9345 punct ",",induces
R6402 T9344 T9345 nsubj WWOX,induces
R6403 T9345 T9345 ROOT induces,induces
R6404 T9346 T9345 dobj apoptosis,induces
R6405 T9347 T9346 prep of,apoptosis
R6406 T9348 T9349 compound U373-MG,cells
R6407 T9349 T9347 pobj cells,of
R6408 T9350 T9345 prep via,induces
R6409 T9351 T9355 det a,pathway
R6410 T9352 T9355 amod mitochondria-independent,pathway
R6411 T9353 T9352 cc and,mitochondria-independent
R6412 T9354 T9352 conj caspase-3-independent,mitochondria-independent
R6413 T9355 T9350 pobj pathway,via
R6414 T9356 T9359 punct (,al.
R6415 T9357 T9359 compound Chiang,al.
R6416 T9358 T9359 nmod et,al.
R6417 T9359 T9345 advcl al.,induces
R6418 T9360 T9359 punct ",",al.
R6419 T9361 T9359 npadvmod 2012,al.
R6420 T9362 T9359 punct ),al.
R6421 T9363 T9345 punct .,induces
R6422 T9364 T9368 mark While,are
R6423 T9365 T9367 det the,mechanisms
R6424 T9366 T9367 amod underlying,mechanisms
R6425 T9367 T9368 nsubj mechanisms,are
R6426 T9368 T9372 advcl are,is
R6427 T9369 T9368 acomp unknown,are
R6428 T9370 T9372 punct ",",is
R6429 T9371 T9372 nsubj it,is
R6430 T9372 T9372 ROOT is,is
R6431 T9373 T9372 acomp reasonable,is
R6432 T9374 T9375 aux to,assume
R6433 T9375 T9372 xcomp assume,is
R6434 T9376 T9383 mark that,depends
R6435 T9377 T9378 det the,survival
R6436 T9378 T9383 nsubj survival,depends
R6437 T9379 T9378 prep of,survival
R6438 T9380 T9382 amod human,cells
R6439 T9381 T9382 compound glioblastoma,cells
R6440 T9382 T9379 pobj cells,of
R6441 T9383 T9375 ccomp depends,assume
R6442 T9384 T9383 prep upon,depends
R6443 T9385 T9384 pobj interactions,upon
R6444 T9386 T9385 prep between,interactions
R6445 T9387 T9388 det the,gain-of-function
R6446 T9388 T9386 pobj gain-of-function,between
R6447 T9389 T9388 prep of,gain-of-function
R6448 T9390 T9391 compound p53,mutants
R6449 T9391 T9389 pobj mutants,of
R6450 T9392 T9391 cc and,mutants
R6451 T9393 T9391 conj WWOX,mutants
R6452 T9394 T9372 punct .,is
R6453 T9395 T9396 compound Activated,WWOX
R6454 T9396 T9397 nsubj WWOX,binds
R6455 T9397 T9397 ROOT binds,binds
R6456 T9398 T9399 amod wild,type
R6457 T9399 T9400 compound type,p53
R6458 T9400 T9397 dobj p53,binds
R6459 T9401 T9397 prep with,binds
R6460 T9402 T9403 compound Ser46,phosphorylation
R6461 T9403 T9401 pobj phosphorylation,with
R6462 T9404 T9407 punct (,al.
R6463 T9405 T9407 compound Chang,al.
R6464 T9406 T9407 nmod et,al.
R6465 T9407 T9407 ROOT al.,al.
R6466 T9408 T9407 punct ",",al.
R6467 T9409 T9407 amod 2005b,al.
R6468 T9410 T9409 punct ),2005b
R6469 T9411 T9407 punct .,al.
R6470 T9412 T9413 compound UV,irradiation
R6471 T9413 T9414 nsubj irradiation,enhances
R6472 T9414 T9414 ROOT enhances,enhances
R6473 T9415 T9417 det the,interactions
R6474 T9416 T9417 amod binding,interactions
R6475 T9417 T9414 dobj interactions,enhances
R6476 T9418 T9414 punct .,enhances
R6477 T9419 T9433 prep Despite,remains
R6478 T9420 T9421 det the,presence
R6479 T9421 T9419 pobj presence,Despite
R6480 T9422 T9421 prep of,presence
R6481 T9423 T9422 pobj Ser46,of
R6482 T9424 T9421 prep in,presence
R6483 T9425 T9424 pobj Δ40p53,in
R6484 T9426 T9433 punct ",",remains
R6485 T9427 T9433 nsubj binding,remains
R6486 T9428 T9427 prep of,binding
R6487 T9429 T9430 det this,protein
R6488 T9430 T9428 pobj protein,of
R6489 T9431 T9427 prep with,binding
R6490 T9432 T9431 pobj WWOX,with
R6491 T9433 T9433 ROOT remains,remains
R6492 T9434 T9436 aux to,determined
R6493 T9435 T9436 auxpass be,determined
R6494 T9436 T9433 xcomp determined,remains
R6495 T9437 T9433 punct .,remains
R6496 T9438 T9439 nsubj We,postulate
R6497 T9439 T9439 ROOT postulate,postulate
R6498 T9440 T9453 mark that,appear
R6499 T9441 T9453 prep in,appear
R6500 T9442 T9443 compound GBM,cells
R6501 T9443 T9441 pobj cells,in
R6502 T9444 T9453 punct ",",appear
R6503 T9445 T9447 preconj both,type
R6504 T9446 T9447 amod wild,type
R6505 T9447 T9453 nsubj type,appear
R6506 T9448 T9452 nmod p53,proteins
R6507 T9449 T9448 cc and,p53
R6508 T9450 T9448 conj ectopic,p53
R6509 T9451 T9452 compound WWOX,proteins
R6510 T9452 T9453 nsubj proteins,appear
R6511 T9453 T9439 ccomp appear,postulate
R6512 T9454 T9455 aux to,have
R6513 T9455 T9453 xcomp have,appear
R6514 T9456 T9458 det a,antagonism
R6515 T9457 T9458 amod functional,antagonism
R6516 T9458 T9455 dobj antagonism,have
R6517 T9459 T9455 punct ",",have
R6518 T9460 T9461 advmod thereby,nullifying
R6519 T9461 T9455 advcl nullifying,have
R6520 T9462 T9463 det each,other
R6521 T9463 T9464 poss other,function
R6522 T9464 T9461 dobj function,nullifying
R6523 T9465 T9464 prep in,function
R6524 T9466 T9465 pcomp inducing,in
R6525 T9467 T9466 dobj apoptosis,inducing
R6526 T9468 T9469 punct (,Figure
R6527 T9469 T9464 appos Figure,function
R6528 T9470 T9469 nummod 2,Figure
R6529 T9471 T9469 punct ),Figure
R6530 T9472 T9439 punct .,postulate
R6531 T9473 T9475 amod Mutant,proteins
R6532 T9474 T9475 compound p53,proteins
R6533 T9475 T9478 nsubj proteins,bind
R6534 T9476 T9478 aux can,bind
R6535 T9477 T9478 neg not,bind
R6536 T9478 T9478 ROOT bind,bind
R6537 T9479 T9480 compound ectopic,WWOX
R6538 T9480 T9478 dobj WWOX,bind
R6539 T9481 T9480 prep in,WWOX
R6540 T9482 T9483 compound GBM,cells
R6541 T9483 T9481 pobj cells,in
R6542 T9484 T9478 punct ",",bind
R6543 T9485 T9478 cc and,bind
R6544 T9486 T9487 nsubj WWOX,is
R6545 T9487 T9478 conj is,bind
R6546 T9488 T9487 acomp able,is
R6547 T9489 T9490 aux to,induce
R6548 T9490 T9488 xcomp induce,able
R6549 T9491 T9490 dobj apoptosis,induce
R6550 T9492 T9487 punct .,is
R6551 T9493 T9495 mark Whether,causes
R6552 T9494 T9495 nsubj WWOX,causes
R6553 T9495 T9502 advcl causes,is
R6554 T9496 T9495 dobj apoptosis,causes
R6555 T9497 T9495 prep in,causes
R6556 T9498 T9499 nsubj GBM,expressing
R6557 T9499 T9497 pcomp expressing,in
R6558 T9500 T9501 compound p53,isoforms
R6559 T9501 T9499 dobj isoforms,expressing
R6560 T9502 T9502 ROOT is,is
R6561 T9503 T9502 acomp unknown,is
R6562 T9504 T9502 cc and,is
R6563 T9505 T9502 conj remains,is
R6564 T9506 T9508 aux to,established
R6565 T9507 T9508 auxpass be,established
R6566 T9508 T9505 xcomp established,remains
R6567 T9509 T9502 punct .,is
R6629 T9985 T9987 mark Whether,affects
R6630 T9986 T9987 nsubj WWOX,affects
R6631 T9987 T9993 advcl affects,determined
R6632 T9988 T9989 compound TMZ,sensitivity
R6633 T9989 T9987 dobj sensitivity,affects
R6634 T9990 T9993 aux has,determined
R6635 T9991 T9993 neg never,determined
R6636 T9992 T9993 auxpass been,determined
R6637 T9993 T9993 ROOT determined,determined
R6638 T9994 T9993 punct .,determined
R6639 T9995 T9996 amod Binding,proteins
R6640 T9996 T10001 nsubj proteins,are
R6641 T9997 T9996 prep for,proteins
R6642 T9998 T9997 pobj WWOX,for
R6643 T9999 T9998 cc and/or,WWOX
R6644 T10000 T9998 conj p53,WWOX
R6645 T10001 T10001 ROOT are,are
R6646 T10002 T10001 acomp likely,are
R6647 T10003 T10004 aux to,affect
R6648 T10004 T10002 xcomp affect,likely
R6649 T10005 T10004 dobj apoptosis,affect
R6650 T10006 T10005 cc and,apoptosis
R6651 T10007 T10008 compound TMZ,sensitivity
R6652 T10008 T10005 conj sensitivity,apoptosis
R6653 T10009 T10008 prep in,sensitivity
R6654 T10010 T10011 compound GBM,cells
R6655 T10011 T10009 pobj cells,in
R6656 T10012 T10001 punct .,are
R6657 T10013 T10014 nsubj WWOX,binds
R6658 T10014 T10014 ROOT binds,binds
R6659 T10015 T10014 dobj MEK,binds
R6660 T10016 T10014 punct ",",binds
R6661 T10017 T10014 cc and,binds
R6662 T10018 T10020 mark that,dissociates
R6663 T10019 T10020 nsubj PMA,dissociates
R6664 T10020 T10014 conj dissociates,binds
R6665 T10021 T10022 det this,complex
R6666 T10022 T10020 dobj complex,dissociates
R6667 T10023 T10020 prep for,dissociates
R6668 T10024 T10023 pcomp causing,for
R7633 T11213 T11214 amod appropriate,chemicals
R7634 T11214 T11224 nsubjpass chemicals,expected
R7635 T11215 T11214 punct ",",chemicals
R7636 T11216 T11217 nsubj which,break
R7637 T11217 T11214 relcl break,chemicals
R7638 T11218 T11217 advmod apart,break
R7639 T11219 T11221 det the,complex
R7640 T11220 T11221 compound WWOX/MEK,complex
R7641 T11221 T11217 dobj complex,break
R7642 T11222 T11214 punct ",",chemicals
R7643 T11223 T11224 auxpass are,expected
R7644 T11224 T11224 ROOT expected,expected
R7645 T11225 T11226 aux to,cause
R7646 T11226 T11224 xcomp cause,expected
R7647 T11227 T11229 compound GBM,death
R7648 T11228 T11229 compound cell,death
R7649 T11229 T11226 dobj death,cause
R7650 T11230 T11224 punct .,expected
R7651 T11231 T11232 amod Preliminary,studies
R7652 T11232 T11239 nsubj studies,selected
R7653 T11233 T11232 prep from,studies
R7654 T11234 T11235 poss our,screening
R7655 T11235 T11233 pobj screening,from
R7656 T11236 T11235 prep of,screening
R7657 T11237 T11236 pobj chemicals,of
R7658 T11238 T11239 aux have,selected
R7659 T11239 T11239 ROOT selected,selected
R7660 T11240 T11242 amod certain,molecules
R7661 T11241 T11242 amod small,molecules
R7662 T11242 T11239 dobj molecules,selected
R7663 T11243 T11244 nsubj that,induce
R7664 T11244 T11242 relcl induce,molecules
R7665 T11245 T10024 dobj apoptosis,causing
R7666 T11246 T11245 prep of,apoptosis
R7667 T11247 T11249 compound T,cells
R7668 T11248 T11249 compound leukemia,cells
R7669 T11249 T11246 pobj cells,of
R7670 T11250 T11253 punct (,al.
R7671 T11251 T11253 compound Lin,al.
R7672 T11252 T11253 nmod et,al.
R7673 T11253 T11245 appos al.,apoptosis
R7674 T11254 T11253 punct ",",al.
R7675 T11255 T11253 npadvmod 2011,al.
R7676 T11256 T11253 punct ),al.
R7677 T11257 T10014 punct .,binds
R7678 T11258 T11224 advmod Thus,expected
R7679 T11259 T11224 punct ",",expected
R7793 T11599 T11244 dobj apoptosis,induce
R7794 T11600 T11599 prep of,apoptosis
R7795 T11601 T11602 amod many,types
R7796 T11602 T11600 pobj types,of
R7797 T11603 T11602 prep of,types
R7798 T11604 T11605 compound cancer,cells
R7799 T11605 T11603 pobj cells,of
R7800 T11606 T11609 punct (,al.
R7801 T11607 T11609 compound Lu,al.
R7802 T11608 T11609 nmod et,al.
R7803 T11609 T11242 appos al.,molecules
R7804 T11610 T11609 punct ",",al.
R7805 T11611 T11609 amod unpublished,al.
R7806 T11612 T11242 punct ),molecules
R7807 T11613 T11239 punct .,selected
R7808 T11614 T11622 advmod Indeed,enhances
R7809 T11615 T11622 punct ",",enhances
R7810 T11616 T11617 amod specific,inhibition
R7811 T11617 T11622 nsubj inhibition,enhances
R7812 T11618 T11617 prep of,inhibition
R7813 T11619 T11618 pobj MEK,of
R7814 T11620 T11617 prep by,inhibition
R7815 T11621 T11620 pobj selumetinib,by
R7816 T11622 T11622 ROOT enhances,enhances
R7817 T11623 T11626 amod TMZ-induced,death
R7818 T11624 T11625 compound cancer,cell
R7819 T11625 T11626 compound cell,death
R7820 T11626 T11622 dobj death,enhances
R7821 T11627 T11626 prep in,death
R7822 T11628 T11627 pobj vivo,in
R7823 T11629 T11632 punct (,al.
R7824 T11630 T11632 compound Holt,al.
R7825 T11631 T11632 nmod et,al.
R7826 T11632 T11622 npadvmod al.,enhances
R7827 T11633 T11632 punct ",",al.
R7828 T11634 T11632 npadvmod 2012,al.
R7829 T11635 T11632 punct ),al.
R7830 T11636 T11622 punct .,enhances
R7831 T11637 T11638 compound Serum,factors
R7832 T11638 T11641 nsubjpass factors,utilized
R7833 T11639 T11641 aux can,utilized
R7834 T11640 T11641 auxpass be,utilized
R7835 T11641 T11641 ROOT utilized,utilized
R7836 T11642 T11641 prep for,utilized
R7837 T11643 T11642 pcomp blocking,for
R7838 T11644 T11645 compound cancer,growth
R7839 T11645 T11643 dobj growth,blocking
R7840 T11646 T11641 punct .,utilized
R7841 T11647 T11653 prep For,induces
R7842 T11648 T11647 pobj example,For
R7843 T11649 T11653 punct ",",induces
R7844 T11650 T11651 compound serum,complement
R7845 T11651 T11653 nsubj complement,induces
R7846 T11652 T11653 nsubj C1q,induces
R7847 T11653 T11653 ROOT induces,induces
R7848 T11654 T11653 dobj apoptosis,induces
R7849 T11655 T11654 prep of,apoptosis
R7850 T11656 T11657 compound prostate,cancer
R7851 T11657 T11655 pobj cancer,of
R7852 T11658 T11657 cc and,cancer
R7853 T11659 T11660 amod neuroblastomas,cells
R7854 T11660 T11657 conj cells,cancer
R7855 T11661 T11653 prep without,induces
R7856 T11662 T11661 pobj participation,without
R7857 T11663 T11662 prep of,participation
R7858 T11664 T11665 amod downstream,proteins
R7859 T11665 T11663 pobj proteins,of
R7860 T11666 T11662 prep in,participation
R7861 T11667 T11670 det the,pathway
R7862 T11668 T11670 amod classical,pathway
R7863 T11669 T11670 compound activation,pathway
R7864 T11670 T11666 pobj pathway,in
R7865 T11671 T11674 punct (,al.
R7866 T11672 T11674 nmod Hong,al.
R7867 T11673 T11674 nmod et,al.
R7868 T11674 T11653 parataxis al.,induces
R7869 T11675 T11674 punct ",",al.
R7870 T11676 T11674 npadvmod 2009,al.
R7871 T11677 T11674 punct ),al.
R7872 T11678 T11653 punct .,induces
R7873 T11679 T11686 prep In,activated
R7874 T11680 T11681 det this,event
R7875 T11681 T11679 pobj event,In
R7876 T11682 T11686 punct ",",activated
R7877 T11683 T11684 compound ectopic,WWOX
R7878 T11684 T11686 nsubjpass WWOX,activated
R7879 T11685 T11686 auxpass is,activated
R7880 T11686 T11686 ROOT activated,activated
R7881 T11687 T11686 prep for,activated
R7882 T11688 T11687 pcomp inducing,for
R7883 T11689 T11688 dobj apoptosis,inducing
R7884 T11690 T11686 punct .,activated
R7885 T11691 T11705 nsubj Failure,is
R7886 T11692 T11691 prep of,Failure
R7887 T11693 T11694 compound ectopic,WWOX
R7888 T11694 T11692 pobj WWOX,of
R7889 T11695 T11691 prep in,Failure
R7890 T11696 T11695 pcomp inducing,in
R7891 T11697 T11696 dobj apoptosis,inducing
R7892 T11698 T11697 prep of,apoptosis
R7893 T11699 T11700 compound glioma,cells
R7894 T11700 T11698 pobj cells,of
R7895 T11701 T11696 conj possessing,inducing
R7896 T11702 T11703 amod wild,type
R7897 T11703 T11704 compound type,p53
R7898 T11704 T11701 dobj p53,possessing
R7899 T11705 T11705 ROOT is,is
R7900 T11706 T11705 acomp unusual,is
R7901 T11707 T11710 punct (,al.
R7902 T11708 T11710 compound Chiang,al.
R7903 T11709 T11710 nmod et,al.
R7904 T11710 T11705 prep al.,is
R7905 T11711 T11710 punct ",",al.
R7906 T11712 T11710 npadvmod 2012,al.
R7907 T11713 T11710 punct ),al.
R7908 T11714 T11705 punct .,is
R7909 T11715 T11721 prep In,shown
R7910 T11716 T11717 amod most,cases
R7911 T11717 T11715 pobj cases,In
R7912 T11718 T11721 punct ",",shown
R7913 T11719 T11721 nsubj we,shown
R7914 T11720 T11721 aux have,shown
R7915 T11721 T11721 ROOT shown,shown
R7916 T11722 T11725 mark that,interacts
R7917 T11723 T11725 nsubj p53,interacts
R7918 T11724 T11725 advmod functionally,interacts
R7919 T11725 T11721 ccomp interacts,shown
R7920 T11726 T11725 prep with,interacts
R7921 T11727 T11726 pobj WWOX,with
R7922 T11728 T11725 punct ",",interacts
R7923 T11729 T11721 cc and,shown
R7924 T11730 T11731 det both,proteins
R7925 T11731 T11732 nsubj proteins,induce
R7926 T11732 T11721 conj induce,shown
R7927 T11733 T11732 dobj apoptosis,induce
R7928 T11734 T11732 prep in,induce
R7929 T11735 T11737 det a,manner
R7930 T11736 T11737 amod synergistic,manner
R7931 T11737 T11734 pobj manner,in
R7932 T11738 T11759 punct (,al.
R7933 T11739 T11741 compound Chang,al.
R7934 T11740 T11741 nmod et,al.
R7935 T11741 T11759 ccomp al.,al.
R7936 T11742 T11741 punct ",",al.
R7937 T11743 T11741 nummod 2001,al.
R7938 T11744 T11743 punct ",",2001
R7939 T11745 T11743 conj 2003,2001
R7940 T11746 T11741 punct ",",al.
R7941 T11747 T11741 appos 2005a,al.
R7942 T11748 T11749 punct ",",b
R7943 T11749 T11741 conj b,al.
R7944 T11750 T11749 punct ",",b
R7945 T11751 T11749 npadvmod 2007,b
R7946 T11752 T11751 punct ",",2007
R7947 T11753 T11751 conj 2010,2007
R7948 T11754 T11753 punct ",",2010
R7949 T11755 T11753 conj 2012,2010
R7950 T11756 T11759 punct ;,al.
R7951 T11757 T11759 compound Su,al.
R7952 T11758 T11759 nmod et,al.
R7953 T11759 T11732 parataxis al.,induce
R7954 T11760 T11759 punct ",",al.
R7955 T11761 T11759 npadvmod 2012,al.
R7956 T11762 T11759 punct ),al.
R7957 T11763 T11721 punct .,shown
R7958 T11764 T11766 det A,scenario
R7959 T11765 T11766 amod likely,scenario
R7960 T11766 T11767 nsubj scenario,is
R7961 T11767 T11767 ROOT is,is
R7962 T11768 T11779 mark that,interfere
R7963 T11769 T11770 amod p53-binding,proteins
R7964 T11770 T11779 nsubj proteins,interfere
R7965 T11771 T11770 punct ",",proteins
R7966 T11772 T11773 nsubj which,are
R7967 T11773 T11770 relcl are,proteins
R7968 T11774 T11773 acomp present,are
R7969 T11775 T11774 prep in,present
R7970 T11776 T11775 pobj GBMs,in
R7971 T11777 T11770 punct ",",proteins
R7972 T11778 T11779 aux may,interfere
R7973 T11779 T11767 ccomp interfere,is
R7974 T11780 T11779 prep with,interfere
R7975 T11781 T11783 det the,function
R7976 T11834 T11833 prep during,upregulated
R7977 T11782 T11783 amod apoptotic,function
R7978 T11835 T11837 det the,stage
R7979 T11836 T11837 amod early,stage
R7980 T11783 T11780 pobj function,with
R7981 T11837 T11834 pobj stage,during
R7982 T11838 T11837 prep of,stage
R7983 T11839 T11840 compound cancer,progression
R7984 T11840 T11838 pobj progression,of
R7985 T11841 T11844 punct (,al.
R7986 T11784 T11783 prep of,function
R7987 T11842 T11844 compound Lai,al.
R7988 T11785 T11784 pobj WWOX,of
R7989 T11843 T11844 nmod et,al.
R7990 T11844 T11837 appos al.,stage
R7991 T11786 T11785 cc and,WWOX
R7992 T11845 T11844 punct ",",al.
R7993 T11846 T11844 npadvmod 2005,al.
R7994 T11847 T11844 punct ;,al.
R7995 T11787 T11785 conj p53,WWOX
R7996 T11848 T11850 compound Chang,al.
R7997 T11849 T11850 nmod et,al.
R7998 T11850 T11833 npadvmod al.,upregulated
R7999 T11788 T11767 punct .,is
R8000 T11851 T11850 punct ",",al.
R8001 T11852 T11850 amod unpublished,al.
R8002 T11789 T11790 amod Functional,antagonism
R8003 T11853 T11833 punct ),upregulated
R8004 T11854 T11805 punct .,is
R8005 T11855 T11858 aux Do,act
R8006 T11856 T11857 det these,proteins
R8007 T11790 T11797 nsubjpass antagonism,documented
R8008 T11857 T11858 nsubj proteins,act
R8009 T11858 T11858 ROOT act,act
R8010 T11791 T11790 prep among,antagonism
R8011 T11859 T11858 advmod synergistically,act
R8012 T11860 T11858 prep in,act
R8013 T11861 T11860 pcomp blocking,in
R8014 T11862 T11863 compound cancer,progression
R8015 T11792 T11793 compound tumor,suppressors
R8016 T11863 T11861 dobj progression,blocking
R8017 T11864 T11858 cc but,act
R8018 T11865 T11858 conj lose,act
R8019 T11793 T11791 pobj suppressors,among
R8020 T11866 T11865 dobj control,lose
R8021 T11867 T11858 advmod eventually,act
R8022 T11868 T11858 punct ?,act
R8023 T11794 T11797 aux has,documented
R8024 T11869 T11873 cc Or,counteract
R8025 T11870 T11873 punct ",",counteract
R8026 T11871 T11873 aux do,counteract
R8027 T11795 T11797 neg never,documented
R8028 T11872 T11873 nsubj they,counteract
R8029 T11873 T11873 ROOT counteract,counteract
R8030 T11874 T11875 det each,other
R8031 T11796 T11797 auxpass been,documented
R8032 T11875 T11876 poss other,function
R8033 T11876 T11873 dobj function,counteract
R8034 T11877 T11873 punct ",",counteract
R8035 T11878 T11879 advmod thus,allowing
R8036 T11879 T11873 advcl allowing,counteract
R8037 T11880 T11881 compound cancer,growth
R8038 T11797 T11797 ROOT documented,documented
R8039 T11881 T11879 dobj growth,allowing
R8040 T11882 T11873 punct ?,counteract
R8041 T11798 T11797 prep in,documented
R8042 T11883 T11886 mark Whether,counteracts
R8043 T11799 T11800 det the,literature
R8044 T11884 T11886 nsubj endogenous,counteracts
R8045 T11885 T11886 nsubj WWOX,counteracts
R8046 T11886 T11893 csubj counteracts,is
R8047 T11800 T11798 pobj literature,in
R8048 T11887 T11886 prep with,counteracts
R8049 T11888 T11889 det the,function
R8050 T11889 T11887 pobj function,with
R8051 T11890 T11889 prep of,function
R8052 T11801 T11797 punct .,documented
R8053 T11891 T11892 amod endogenous,p53
R8054 T11892 T11890 pobj p53,of
R8055 T11802 T11805 advmod However,is
R8056 T11893 T11893 ROOT is,is
R8057 T11894 T11893 acomp unknown,is
R8058 T11895 T11893 cc and,is
R8059 T11803 T11805 punct ",",is
R8060 T11896 T11893 conj remains,is
R8061 T11897 T11899 aux to,established
R8062 T11898 T11899 auxpass be,established
R8063 T11804 T11805 nsubj it,is
R8064 T11899 T11896 xcomp established,remains
R8065 T11900 T11893 punct .,is
R8066 T11805 T11805 ROOT is,is
R8067 T11901 T11909 nsubj One,is
R8068 T11902 T11901 prep of,One
R8069 T11903 T11905 det the,characteristics
R8070 T11904 T11905 amod unique,characteristics
R8071 T11806 T11807 neg not,surprising
R8072 T11905 T11902 pobj characteristics,of
R8073 T11906 T11905 prep for,characteristics
R8074 T11907 T11908 amod malignant,gliomas
R8075 T11807 T11805 acomp surprising,is
R8076 T11908 T11906 pobj gliomas,for
R8077 T11909 T11909 ROOT is,is
R8078 T11910 T11912 poss their,infiltration
R8079 T11911 T11912 compound diffuse,infiltration
R8080 T11808 T11809 aux to,find
R8081 T11912 T11909 attr infiltration,is
R8082 T11913 T11912 prep into,infiltration
R8083 T11914 T11916 amod distant,tissue
R8084 T11915 T11916 compound brain,tissue
R8085 T11916 T11913 pobj tissue,into
R8086 T11917 T11909 punct .,is
R8087 T11809 T11805 xcomp find,is
R8088 T11918 T11919 compound Signal,pathways
R8089 T11919 T11934 nsubjpass pathways,believed
R8090 T11920 T11919 punct ",",pathways
R8091 T11810 T11833 mark that,upregulated
R8092 T11921 T11919 acl involving,pathways
R8093 T11922 T11921 dobj PI3K,involving
R8094 T11923 T11922 punct ",",PI3K
R8095 T11811 T11814 amod many,proteins
R8096 T11924 T11922 conj Akt,PI3K
R8097 T11925 T11924 punct ",",Akt
R8098 T11926 T11924 conj mTOR,Akt
R8099 T11812 T11814 compound tumor,proteins
R8100 T11927 T11926 punct ",",mTOR
R8101 T11928 T11926 conj NF-κB,mTOR
R8102 T11929 T11928 punct ",",NF-κB
R8103 T11930 T11928 cc and,NF-κB
R8104 T11813 T11814 compound suppressor,proteins
R8105 T11814 T11833 nsubjpass proteins,upregulated
R8106 T11815 T11814 punct ",",proteins
R8107 T11931 T11928 conj autophagy,NF-κB
R8108 T11932 T11934 punct ",",believed
R8109 T11933 T11934 auxpass are,believed
R8110 T11816 T11814 conj e.g.,proteins
R8111 T11934 T11934 ROOT believed,believed
R8112 T11935 T11936 aux to,confer
R8113 T11936 T11934 xcomp confer,believed
R8114 T11937 T11939 det these,cells
R8115 T11817 T11816 punct ",",e.g.
R8116 T11938 T11939 amod migrating,cells
R8117 T11818 T11816 conj p53,e.g.
R8118 T11939 T11936 dobj cells,confer
R8119 T11940 T11936 advmod resistant,confer
R8120 T11941 T11940 prep to,resistant
R8121 T11942 T11943 amod apoptotic,death
R8122 T11819 T11818 punct ",",p53
R8123 T11943 T11941 pobj death,to
R8124 T11944 T11947 punct (,al.
R8125 T11945 T11947 nmod Lefranc,al.
R8126 T11946 T11947 nmod et,al.
R8127 T11820 T11818 conj WWOX,p53
R8128 T11947 T11936 advmod al.,confer
R8129 T11948 T11947 punct ",",al.
R8130 T11949 T11947 npadvmod 2005,al.
R8131 T11950 T11934 punct ),believed
R8132 T11821 T11820 punct ",",WWOX
R8133 T11951 T11934 punct .,believed
R8134 T11952 T11953 compound Glioma,cells
R8135 T11953 T11954 nsubj cells,possess
R8136 T11954 T11974 ccomp possess,al.
R8137 T11955 T11954 dobj CD44,possess
R8138 T11956 T11954 prep as,possess
R8139 T11822 T11820 conj Smad4,WWOX
R8140 T11957 T11958 det a,receptor
R8141 T11958 T11956 pobj receptor,as
R8142 T11959 T11958 prep for,receptor
R8143 T11960 T11959 pcomp interacting,for
R8144 T11823 T11822 punct ",",Smad4
R8145 T11961 T11960 prep with,interacting
R8146 T11824 T11822 conj PTEN,Smad4
R8147 T11962 T11964 compound brain,hyaluronan
R8148 T11825 T11824 punct ",",PTEN
R8149 T11963 T11964 compound matrix,hyaluronan
R8150 T11964 T11961 pobj hyaluronan,with
R8151 T11826 T11824 conj PP2A,PTEN
R8152 T11965 T11968 punct (,al.
R8153 T11966 T11968 compound Murai,al.
R8154 T11967 T11968 nmod et,al.
R8155 T11827 T11826 punct ",",PP2A
R8156 T11968 T11964 appos al.,hyaluronan
R8157 T11969 T11968 punct ",",al.
R8158 T11970 T11968 npadvmod 2004,al.
R8159 T11828 T11826 cc and,PP2A
R8160 T11971 T11974 punct ;,al.
R8161 T11972 T11974 compound Yoshida,al.
R8162 T11973 T11974 nmod et,al.
R8163 T11829 T11826 conj etc.,PP2A
R8164 T11974 T11974 ROOT al.,al.
R8165 T11975 T11974 punct ",",al.
R8166 T11976 T11974 npadvmod 2012,al.
R8167 T11830 T11833 punct ",",upregulated
R8168 T11977 T11974 punct ),al.
R8169 T11978 T11974 punct ",",al.
R8170 T11831 T11833 auxpass are,upregulated
R8171 T11979 T11974 cc and,al.
R8172 T11980 T11974 conj secrete,al.
R8173 T11981 T11980 dobj hyaluronidases,secrete
R8174 T11832 T11833 advmod significantly,upregulated
R8175 T11982 T11981 cc and,hyaluronidases
R8176 T11983 T11981 conj metalloproteinases,hyaluronidases
R8177 T11984 T11985 aux to,facilitate
R8178 T11833 T11809 ccomp upregulated,find
R8179 T11985 T11980 advcl facilitate,secrete
R8180 T11986 T11987 poss their,migration
R8181 T11987 T11985 dobj migration,facilitate
R8182 T12028 T12027 dobj migration,facilitates
R8183 T11988 T11991 punct (,al.
R8184 T11989 T11991 compound Delpech,al.
R8185 T11990 T11991 nmod et,al.
R8186 T11991 T11985 npadvmod al.,facilitate
R8187 T12029 T12028 prep of,migration
R8188 T11992 T11991 punct ",",al.
R8189 T11993 T11991 npadvmod 2002,al.
R8190 T11994 T11991 punct ;,al.
R8191 T11995 T11997 compound Junker,al.
R8192 T12030 T12031 compound ovarian,cancer
R8193 T11996 T11997 compound et,al.
R8194 T11997 T11991 conj al.,al.
R8195 T11998 T11997 punct ",",al.
R8196 T12031 T12029 pobj cancer,of
R8197 T11999 T11997 appos 2003,al.
R8198 T12000 T11985 punct ;,facilitate
R8199 T12001 T12003 compound Hagemann,al.
R8200 T12032 T12031 cc and,cancer
R8201 T12002 T12003 compound et,al.
R8202 T12003 T11980 conj al.,secrete
R8203 T12004 T12003 punct ",",al.
R8204 T12033 T12034 compound osteosarcoma,cells
R8205 T12005 T12003 npadvmod 2012,al.
R8206 T12006 T12003 punct ),al.
R8207 T12007 T11974 punct .,al.
R8208 T12008 T12015 advmod Also,expected
R8209 T12034 T12031 conj cells,cancer
R8210 T12009 T12015 punct ",",expected
R8211 T12010 T12015 nsubjpass lack,expected
R8212 T12011 T12010 prep of,lack
R8213 T12035 T12028 punct (,migration
R8214 T12012 T12013 compound WWOX,expression
R8215 T12013 T12011 pobj expression,of
R8216 T12036 T12038 compound Gourley,al.
R8217 T12014 T12015 auxpass is,expected
R8218 T12015 T12015 ROOT expected,expected
R8219 T12016 T12017 aux to,enhance
R8220 T12037 T12038 nmod et,al.
R8221 T12017 T12015 xcomp enhance,expected
R8222 T12018 T12019 compound cell,migration
R8223 T12038 T12028 appos al.,migration
R8224 T12019 T12017 dobj migration,enhance
R8225 T12020 T12015 punct .,expected
R8226 T12021 T12027 prep For,facilitates
R8227 T12039 T12038 punct ",",al.
R8228 T12022 T12021 pobj example,For
R8229 T12023 T12027 punct ",",facilitates
R8230 T12024 T12027 nsubj loss,facilitates
R8231 T12040 T12038 npadvmod 2009,al.
R8232 T12025 T12024 prep of,loss
R8233 T12026 T12025 pobj WWOX,of
R8234 T12027 T12045 ccomp facilitates,al.
R8235 T12041 T12045 punct ;,al.
R8236 T12042 T12043 compound Del,Mare
R8237 T12043 T12045 compound Mare,al.
R8238 T12125 T12131 prep In,migrate
R8239 T12044 T12045 nmod et,al.
R8240 T12126 T12125 pobj contrast,In
R8241 T12127 T12131 punct ",",migrate
R8242 T12128 T12130 amod wild,cells
R8243 T12045 T12045 ROOT al.,al.
R8244 T12129 T12130 compound type,cells
R8245 T12130 T12131 nsubj cells,migrate
R8246 T12131 T12131 ROOT migrate,migrate
R8247 T12046 T12045 punct ",",al.
R8248 T12132 T12131 advmod collectively,migrate
R8249 T12133 T12136 punct (,al.
R8250 T12047 T12045 npadvmod 2011,al.
R8251 T12134 T12136 compound Chou,al.
R8252 T12135 T12136 nmod et,al.
R8253 T12136 T12131 parataxis al.,migrate
R8254 T12137 T12136 punct ",",al.
R8255 T12048 T12045 punct ),al.
R8256 T12138 T12136 amod unpublished,al.
R8257 T12139 T12136 punct ),al.
R8258 T12140 T12131 punct .,migrate
R8259 T12049 T12045 punct .,al.
R8260 T12141 T12147 mark While,anchored
R8261 T12142 T12143 det a,portion
R8262 T12143 T12147 nsubjpass portion,anchored
R8263 T12050 T12051 amod Ectopic,expression
R8264 T12144 T12143 prep of,portion
R8265 T12145 T12144 pobj WWOX,of
R8266 T12146 T12147 auxpass is,anchored
R8267 T12147 T12155 advcl anchored,lose
R8268 T12051 T12051 ROOT expression,expression
R8269 T12148 T12147 prep on,anchored
R8270 T12052 T12051 prep of,expression
R8271 T12149 T12151 det the,membrane/cytoskeleton
R8272 T12150 T12151 compound cell,membrane/cytoskeleton
R8273 T12151 T12148 pobj membrane/cytoskeleton,on
R8274 T12053 T12052 pobj TIAF1,of
R8275 T12152 T12155 punct ",",lose
R8276 T12054 T12057 punct (,factor
R8277 T12153 T12154 amod WWOX-negative,cells
R8278 T12154 T12155 nsubj cells,lose
R8279 T12055 T12057 amod TGF-β-induced,factor
R8280 T12155 T12155 ROOT lose,lose
R8281 T12156 T12155 dobj recognition,lose
R8282 T12157 T12155 prep by,lose
R8283 T12158 T12160 amod parental,cells
R8284 T12159 T12160 amod WWOX-positive,cells
R8285 T12056 T12057 amod antiapoptotic,factor
R8286 T12160 T12157 pobj cells,by
R8287 T12161 T12155 punct ",",lose
R8288 T12162 T12155 cc and,lose
R8289 T12163 T12164 nsubj this,increases
R8290 T12057 T12051 appos factor,expression
R8291 T12164 T12155 conj increases,lose
R8292 T12165 T12166 det the,mobility
R8293 T12166 T12164 dobj mobility,increases
R8294 T12058 T12051 punct ),expression
R8295 T12167 T12166 prep of,mobility
R8296 T12168 T12169 amod WWOX-negative,cells
R8297 T12169 T12167 pobj cells,of
R8298 T12059 T12051 punct ",",expression
R8299 T12170 T12171 aux to,move
R8300 T12171 T12164 xcomp move,increases
R8301 T12172 T12171 advmod away,move
R8302 T12060 T12051 conj p53,expression
R8303 T12173 T12172 prep from,away
R8304 T12174 T12176 det the,cells
R8305 T12175 T12176 amod WWOX-positive,cells
R8306 T12061 T12060 punct ",",p53
R8307 T12176 T12173 pobj cells,from
R8308 T12177 T12164 punct .,increases
R8309 T12062 T12051 cc and,expression
R8310 T12063 T12064 nsubj WWOX,suppresses
R8311 T12178 T12183 advmod Conceivably,migrate
R8312 T12064 T12064 ROOT suppresses,suppresses
R8313 T12179 T12183 punct ",",migrate
R8314 T12180 T12182 amod WWOX-negative,cells
R8315 T12065 T12066 amod anchorage-independent,growth
R8316 T12066 T12064 dobj growth,suppresses
R8317 T12067 T12066 cc and,growth
R8318 T12181 T12182 compound glioma,cells
R8319 T12182 T12183 nsubj cells,migrate
R8320 T12068 T12069 compound cell,migration
R8321 T12183 T12183 ROOT migrate,migrate
R8322 T12184 T12183 advmod individually,migrate
R8323 T12185 T12183 cc and,migrate
R8324 T12186 T12183 conj turn,migrate
R8325 T12069 T12066 conj migration,growth
R8326 T12187 T12186 advmod away,turn
R8327 T12070 T12064 cc and,suppresses
R8328 T12188 T12187 prep from,away
R8329 T12189 T12191 amod WWOX-expressing,cells
R8330 T12190 T12191 compound brain,cells
R8331 T12191 T12188 pobj cells,from
R8332 T12071 T12064 conj causes,suppresses
R8333 T12192 T12186 prep to,turn
R8334 T12193 T12196 amod low,areas
R8335 T12194 T12196 compound WWOX,areas
R8336 T12072 T12071 dobj apoptosis,causes
R8337 T12195 T12196 compound expression,areas
R8338 T12073 T12071 prep in,causes
R8339 T12196 T12192 pobj areas,to
R8340 T12197 T12183 punct .,migrate
R8341 T12198 T12208 advmod Apparently,account
R8342 T12074 T12075 compound cancer,cells
R8343 T12199 T12208 punct ",",account
R8344 T12200 T12202 det the,behavior
R8345 T12201 T12202 amod migratory,behavior
R8346 T12075 T12073 pobj cells,in
R8347 T12202 T12208 nsubj behavior,account
R8348 T12203 T12202 prep of,behavior
R8349 T12076 T12079 punct (,al.
R8350 T12204 T12206 amod WWOX-negative,cells
R8351 T12205 T12206 compound glioma,cells
R8352 T12206 T12203 pobj cells,of
R8353 T12077 T12079 compound Chang,al.
R8354 T12207 T12208 aux may,account
R8355 T12208 T12208 ROOT account,account
R8356 T12209 T12208 prep for,account
R8357 T12078 T12079 nmod et,al.
R8358 T12210 T12212 det the,invasion
R8359 T12211 T12212 compound diffuse,invasion
R8360 T12212 T12209 pobj invasion,for
R8361 T12213 T12212 prep into,invasion
R8362 T12079 T12051 appos al.,expression
R8363 T12214 T12216 amod distant,tissue
R8364 T12215 T12216 compound brain,tissue
R8365 T12216 T12213 pobj tissue,into
R8366 T12080 T12079 punct ",",al.
R8367 T12217 T12212 punct (,invasion
R8368 T12218 T12220 compound Chou,al.
R8369 T12219 T12220 nmod et,al.
R8370 T12081 T12079 npadvmod 2012,al.
R8371 T12220 T12212 appos al.,invasion
R8372 T12221 T12220 punct ",",al.
R8373 T12082 T12079 punct ),al.
R8374 T12083 T12051 punct .,expression
R8375 T12222 T12220 amod unpublished,al.
R8376 T12084 T12085 nsubj We,believe
R8377 T12223 T12212 punct ),invasion
R8378 T12224 T12208 punct .,account
R8379 T12225 T12226 amod Metabolic,alterations
R8380 T12085 T12085 ROOT believe,believe
R8381 T12226 T12229 nsubjpass alterations,shown
R8382 T12086 T12095 mark that,migrate
R8383 T12227 T12229 aux have,shown
R8384 T12228 T12229 auxpass been,shown
R8385 T12229 T12229 ROOT shown,shown
R8386 T12230 T12229 prep in,shown
R8387 T12231 T12233 compound Wwox,mice
R8388 T12087 T12088 amod glioma,cells
R8389 T12232 T12233 compound knockout,mice
R8390 T12088 T12095 nsubj cells,migrate
R8391 T12233 T12230 pobj mice,in
R8392 T12234 T12233 punct ",",mice
R8393 T12235 T12233 prep including,mice
R8394 T12089 T12088 punct ",",cells
R8395 T12236 T12237 amod postnatal,lethality
R8396 T12237 T12235 pobj lethality,including
R8397 T12238 T12237 punct ",",lethality
R8398 T12090 T12088 prep with,cells
R8399 T12239 T12241 compound bone,defects
R8400 T12240 T12241 compound metabolism,defects
R8401 T12241 T12237 conj defects,lethality
R8402 T12091 T12093 compound stem,properties
R8403 T12242 T12241 punct ",",defects
R8404 T12243 T12241 conj ataxia,defects
R8405 T12244 T12243 punct ",",ataxia
R8406 T12092 T12093 compound cell-like,properties
R8407 T12245 T12243 conj steroidogenesis,ataxia
R8408 T12246 T12245 punct ",",steroidogenesis
R8409 T12247 T12245 cc and,steroidogenesis
R8410 T12093 T12090 pobj properties,with
R8411 T12248 T12245 conj generation,steroidogenesis
R8412 T12249 T12245 prep of,steroidogenesis
R8413 T12094 T12095 punct ",",migrate
R8414 T12250 T12249 pobj osteosarcomas,of
R8415 T12251 T12250 punct (,osteosarcomas
R8416 T12252 T12253 compound Del,Mare
R8417 T12095 T12085 ccomp migrate,believe
R8418 T12253 T12255 nmod Mare,al.
R8419 T12254 T12255 nmod et,al.
R8420 T12255 T12250 appos al.,osteosarcomas
R8421 T12096 T12095 advmod individually,migrate
R8422 T12256 T12255 punct ",",al.
R8423 T12257 T12255 npadvmod 2011,al.
R8424 T12258 T12250 punct ;,osteosarcomas
R8425 T12097 T12098 advmod rather,than
R8426 T12259 T12261 compound Salah,al.
R8427 T12260 T12261 nmod et,al.
R8428 T12261 T12250 conj al.,osteosarcomas
R8429 T12098 T12096 cc than,individually
R8430 T12262 T12261 punct ",",al.
R8431 T12263 T12261 npadvmod 2012,al.
R8432 T12099 T12096 conj collectively,individually
R8433 T12264 T12245 punct ),steroidogenesis
R8434 T12265 T12229 punct .,shown
R8435 T12266 T12273 prep In,shown
R8436 T12267 T12269 det a,model
R8437 T12268 T12269 compound Drosophila,model
R8438 T12269 T12266 pobj model,In
R8439 T12270 T12273 punct ",",shown
R8440 T12100 T12085 punct .,believe
R8441 T12271 T12273 nsubjpass Wwox,shown
R8442 T12272 T12273 auxpass is,shown
R8443 T12273 T12273 ROOT shown,shown
R8444 T12101 T12102 det This,assumption
R8445 T12102 T12104 nsubjpass assumption,based
R8446 T12274 T12275 aux to,participate
R8447 T12275 T12273 xcomp participate,shown
R8448 T12103 T12104 auxpass is,based
R8449 T12276 T12275 prep in,participate
R8450 T12277 T12276 pobj pathways,in
R8451 T12104 T12104 ROOT based,based
R8452 T12105 T12104 prep upon,based
R8453 T12278 T12277 acl involving,pathways
R8454 T12106 T12107 poss our,observations
R8455 T12279 T12280 amod aerobic,metabolism
R8456 T12280 T12278 dobj metabolism,involving
R8457 T12281 T12280 cc and,metabolism
R8458 T12107 T12105 pobj observations,upon
R8459 T12282 T12283 amod oxidative,stress
R8460 T12283 T12280 conj stress,metabolism
R8461 T12108 T12120 mark that,migrate
R8462 T12284 T12283 prep for,stress
R8463 T12285 T12284 pobj generation,for
R8464 T12286 T12285 prep of,generation
R8465 T12109 T12113 compound mouse,cells
R8466 T12287 T12286 pobj ROS,of
R8467 T12288 T12287 punct (,ROS
R8468 T12289 T12290 compound et,al.
R8469 T12110 T12113 compound Wwox,cells
R8470 T12290 T12287 appos al.,ROS
R8471 T12291 T12290 punct ",",al.
R8472 T12111 T12112 compound gene,knockout
R8473 T12292 T12290 npadvmod 2011,al.
R8474 T12293 T12287 punct ),ROS
R8475 T12294 T12273 punct .,shown
R8476 T12112 T12113 compound knockout,cells
R8477 T12295 T12303 prep Under,induces
R8478 T12296 T12297 compound UV,stress
R8479 T12297 T12295 pobj stress,Under
R8480 T12113 T12120 nsubj cells,migrate
R8481 T12298 T12303 punct ",",induces
R8482 T12299 T12302 amod functional,expression
R8483 T12114 T12113 punct (,cells
R8484 T12300 T12302 compound Wwox,expression
R8485 T12301 T12302 compound gene,expression
R8486 T12302 T12303 nsubj expression,induces
R8487 T12303 T12303 ROOT induces,induces
R8488 T12304 T12305 compound ROS,production
R8489 T12305 T12303 dobj production,induces
R8490 T12115 T12120 nsubj e.g.,migrate
R8491 T12306 T12305 prep in,production
R8492 T12307 T12306 pobj Drosophila,in
R8493 T12308 T12303 punct .,induces
R8494 T12309 T12310 compound Cancer,cells
R8495 T12116 T12118 punct ",",fibroblasts
R8496 T12117 T12118 amod embryonic,fibroblasts
R8497 T12310 T12312 nsubjpass cells,known
R8498 T12118 T12115 appos fibroblasts,e.g.
R8499 T12311 T12312 auxpass are,known
R8500 T12312 T12312 ROOT known,known
R8501 T12313 T12315 aux to,utilize
R8502 T12119 T12115 punct ),e.g.
R8503 T12314 T12315 advmod overly,utilize
R8504 T12315 T12312 xcomp utilize,known
R8505 T12316 T12315 dobj glycolysis,utilize
R8506 T12120 T12104 ccomp migrate,based
R8507 T12317 T12315 prep for,utilize
R8508 T12318 T12319 compound growth,advantage
R8509 T12121 T12120 advmod individually,migrate
R8510 T12122 T12121 cc and,individually
R8511 T12123 T12121 conj aggressively,individually
R8512 T12319 T12317 pobj advantage,for
R8513 T12124 T12104 punct .,based
R8514 T12320 T12322 det the,Warburg
R8515 T12321 T12322 amod so-called,Warburg
R8516 T12322 T12315 dobj Warburg,utilize
R8517 T12375 T12373 conj WWOX,p53
R8518 T12323 T12326 punct (,al.
R8519 T12376 T12369 prep in,role
R8520 T12324 T12326 nmod Moncada,al.
R8521 T12325 T12326 nmod et,al.
R8522 T12326 T12322 nummod al.,Warburg
R8523 T12377 T12376 pcomp regulating,in
R8524 T12327 T12326 punct ",",al.
R8525 T12328 T12326 npadvmod 2012,al.
R8526 T12329 T12326 punct ),al.
R8527 T12378 T12379 compound TMZ,sensitivity
R8528 T12330 T12312 punct .,known
R8529 T12331 T12334 advmod Conceivably,is
R8530 T12332 T12334 punct ",",is
R8531 T12333 T12334 nsubj WWOX,is
R8532 T12379 T12377 dobj sensitivity,regulating
R8533 T12334 T12334 ROOT is,is
R8534 T12335 T12334 acomp likely,is
R8535 T12336 T12337 aux to,override
R8536 T12337 T12335 xcomp override,likely
R8537 T12338 T12339 compound glucose,consumption
R8538 T12380 T12379 prep in,sensitivity
R8539 T12339 T12337 dobj consumption,override
R8540 T12340 T12337 prep in,override
R8541 T12341 T12342 compound cancer,cells
R8542 T12342 T12340 pobj cells,in
R8543 T12381 T12382 compound GBM,cells
R8544 T12343 T12334 cc and,is
R8545 T12344 T12345 compound exerts,generation
R8546 T12345 T12349 nsubj generation,curb
R8547 T12382 T12380 pobj cells,in
R8548 T12346 T12345 prep of,generation
R8549 T12347 T12346 pobj ROS,of
R8550 T12348 T12349 aux to,curb
R8551 T12383 T12366 punct .,discussed
R8552 T12349 T12334 conj curb,is
R8553 T12350 T12353 det the,growth
R8554 T12351 T12352 compound cancer,cell
R8555 T12384 T12386 nsubj We,shown
R8556 T12385 T12386 aux have,shown
R8557 T12352 T12353 compound cell,growth
R8558 T12386 T12386 ROOT shown,shown
R8559 T12353 T12349 dobj growth,curb
R8560 T12354 T12353 cc and,growth
R8561 T12387 T12388 det the,role
R8562 T12355 T12353 conj invasion,growth
R8563 T12356 T12334 punct .,is
R8564 T12357 T12366 prep In,discussed
R8565 T12358 T12357 pobj summary,In
R8566 T12388 T12386 dobj role,shown
R8567 T12359 T12366 punct ",",discussed
R8568 T12360 T12366 prep in,discussed
R8569 T12389 T12388 prep of,role
R8570 T12361 T12363 det this,article
R8571 T12362 T12363 compound perspective,article
R8572 T12363 T12360 pobj article,in
R8573 T12390 T12389 pobj WWOX,of
R8574 T12364 T12366 nsubj we,discussed
R8575 T12365 T12366 aux have,discussed
R8576 T12366 T12366 ROOT discussed,discussed
R8577 T12391 T12388 prep in,role
R8578 T12367 T12369 det the,role
R8579 T12368 T12369 amod potential,role
R8580 T12392 T12391 pcomp controlling,in
R8581 T12393 T12394 compound cell,migration
R8582 T12394 T12392 dobj migration,controlling
R8583 T12369 T12366 dobj role,discussed
R8584 T12395 T12394 cc and,migration
R8585 T12370 T12369 prep of,role
R8586 T12371 T12372 compound tumor,suppressors
R8587 T12372 T12373 compound suppressors,p53
R8588 T12373 T12370 pobj p53,of
R8589 T12374 T12373 cc and,p53
R8590 T12396 T12397 amod metabolic,alterations
R8591 T12397 T12394 conj alterations,migration
R8592 T12398 T12386 punct ",",shown
R8593 T12399 T12386 cc and,shown
R8594 T12400 T12386 conj discussed,shown
R8595 T12401 T12402 det the,effects
R8596 T12402 T12400 dobj effects,discussed
R8597 T12403 T12402 prep of,effects
R8598 T12404 T12405 compound WWOX,deficiency
R8599 T12405 T12403 pobj deficiency,of
R8600 T12406 T12405 cc and,deficiency
R8601 T12407 T12408 compound TMZ,resistance
R8602 T12408 T12405 conj resistance,deficiency
R8603 T12409 T12400 prep in,discussed
R8604 T12410 T12411 compound cancer,cells
R8605 T12411 T12409 pobj cells,in
R8606 T12412 T12386 punct .,shown
R8656 T12540 T12541 compound Ming-Fu,Chiang
R8657 T12541 T12545 nsubj Chiang,wrote
R8658 T12542 T12541 cc and,Chiang
R8659 T12543 T12544 compound Chun-I,Sze
R8660 T12544 T12541 conj Sze,Chiang
R8661 T12545 T12554 ccomp wrote,wrote
R8662 T12546 T12547 det the,sections
R8663 T12547 T12545 dobj sections,wrote
R8664 T12548 T12547 acl dealing,sections
R8665 T12549 T12548 prep with,dealing
R8666 T12550 T12549 pobj TMZ,with
R8667 T12551 T12554 punct ;,wrote
R8668 T12552 T12553 compound Pei-Yi,Chou
R8669 T12553 T12554 nsubj Chou,wrote
R8670 T12554 T12554 ROOT wrote,wrote
R8671 T12555 T12557 det the,sections
R8672 T12556 T12557 compound review,sections
R8673 T12557 T12554 dobj sections,wrote
R8674 T12558 T12557 prep for,sections
R8675 T12559 T12558 pobj p53,for
R8676 T12560 T12559 cc and,p53
R8677 T12561 T12559 conj WWOX,p53
R8678 T12562 T12561 cc and,WWOX
R8679 T12563 T12564 amod designed,graphs
R8680 T12564 T12561 conj graphs,WWOX
R8681 T12565 T12568 punct ;,managed
R8682 T12566 T12567 compound Wan-Jen,Wang
R8683 T12567 T12568 nsubj Wang,managed
R8684 T12568 T12573 ccomp managed,conceived
R8685 T12569 T12568 dobj citations,managed
R8686 T12570 T12573 punct ;,conceived
R8687 T12571 T12572 compound Nan-Shan,Chang
R8688 T12572 T12573 nsubj Chang,conceived
R8689 T12573 T12554 ccomp conceived,wrote
R8690 T12574 T12573 dobj ideas,conceived
R8691 T12575 T12573 punct ",",conceived
R8692 T12576 T12573 conj wrote,conceived
R8693 T12577 T12576 cc and,wrote
R8694 T12578 T12579 advmod thoroughly,revised
R8695 T12579 T12576 conj revised,wrote
R8696 T12580 T12581 det the,manuscript
R8697 T12581 T12579 dobj manuscript,revised
R8698 T12582 T12579 punct ",",revised
R8699 T12583 T12579 cc and,revised
R8700 T12584 T12579 conj discussed,revised
R8701 T12585 T12584 prep with,discussed
R8702 T12586 T12585 pobj coauthors,with
R8703 T12587 T12554 punct .,wrote
R8734 T12618 T12619 det The,authors
R8735 T12619 T12620 nsubj authors,declare
R8736 T12620 T12620 ROOT declare,declare
R8737 T12621 T12625 mark that,conducted
R8738 T12622 T12623 det the,research
R8739 T12623 T12625 nsubjpass research,conducted
R8740 T12624 T12625 auxpass was,conducted
R8741 T12625 T12620 ccomp conducted,declare
R8742 T12626 T12625 prep in,conducted
R8743 T12627 T12628 det the,absence
R8744 T12628 T12626 pobj absence,in
R8745 T12629 T12628 prep of,absence
R8746 T12630 T12631 det any,commercial
R8747 T12631 T12634 amod commercial,relationships
R8748 T12632 T12631 cc or,commercial
R8749 T12633 T12631 conj financial,commercial
R8750 T12634 T12629 pobj relationships,of
R8751 T12635 T12638 nsubjpass that,construed
R8752 T12636 T12638 aux could,construed
R8753 T12637 T12638 auxpass be,construed
R8754 T12638 T12634 relcl construed,relationships
R8755 T12639 T12638 prep as,construed
R8756 T12640 T12642 det a,conflict
R8757 T12641 T12642 amod potential,conflict
R8758 T12642 T12639 pobj conflict,as
R8759 T12643 T12642 prep of,conflict
R8760 T12644 T12643 pobj interest,of
R8761 T12645 T12620 punct .,declare
R8927 T12940 T13959 punct .,is
R8928 T12941 T12947 prep In,binds
R8929 T12942 T12941 pobj response,In
R8930 T12943 T12942 prep to,response
R8931 T12944 T12943 pobj TGF-β1,to
R8932 T12945 T12947 punct ",",binds
R8933 T12946 T12947 nsubj WWOX,binds
R8934 T12947 T12947 ROOT binds,binds
R8935 T12948 T12947 dobj Hyal-2,binds
R8936 T12949 T12948 cc and,Hyal-2
R8937 T12950 T12948 conj forms,Hyal-2
R8938 T12951 T12952 det a,complex
R8939 T12952 T12950 dobj complex,forms
R8940 T12953 T12950 punct ",",forms
R8941 T12954 T12947 advcl followed,binds
R8942 T12955 T12954 agent by,followed
R8943 T12956 T12955 pcomp relocating,by
R8944 T12957 T12956 prep to,relocating
R8945 T12958 T12959 det the,nucleus
R8946 T12959 T12957 pobj nucleus,to
R8947 T12960 T12956 cc and,relocating
R8948 T12961 T12956 conj enhancing,relocating
R8949 T12962 T12965 det the,activity
R8950 T12963 T12965 amod SMAD-driven,activity
R8951 T12964 T12965 compound promoter,activity
R8952 T12965 T12961 dobj activity,enhancing
R8953 T12966 T12947 punct .,binds
R8954 T12967 T12967 ROOT Ack1,Ack1
R8955 T12968 T12967 punct ",",Ack1
R8956 T12969 T12974 amod activated,Hyal-2
R8957 T12970 T12971 amod Cdc42-associated,kinase
R8958 T12971 T12969 dobj kinase,activated
R8959 T12972 T12971 nummod 1,kinase
R8960 T12973 T12969 punct ;,activated
R8961 T12974 T12967 conj Hyal-2,Ack1
R8962 T12975 T12974 punct ",",Hyal-2
R8963 T12976 T12979 nmod hyaluronoglucosaminidase,CKI
R8964 T12977 T12976 nummod 2,hyaluronoglucosaminidase
R8965 T12978 T12979 punct ;,CKI
R8966 T12979 T12974 conj CKI,Hyal-2
R8967 T12980 T12979 punct ",",CKI
R8968 T12981 T12982 compound casein,kinase
R8969 T12982 T12979 appos kinase,CKI
R8970 T12983 T12979 punct ;,CKI
R8971 T12984 T12979 conj GSK,CKI
R8972 T12985 T12984 punct ",",GSK
R8973 T12986 T12988 nmod glycogen,kinase
R8974 T12987 T12988 compound synthase,kinase
R8975 T12988 T12984 appos kinase,GSK
R8976 T12989 T12984 punct ;,GSK
R8977 T12990 T12984 conj PKA,GSK
R8978 T12991 T12990 punct ",",PKA
R8979 T12992 T12994 compound protein,A.
R8980 T12993 T12994 compound kinase,A.
R8981 T12994 T12990 appos A.,PKA
R9379 T13557 T13558 amod Schematic,diagrams
R9380 T13558 T13558 ROOT diagrams,diagrams
R9381 T13559 T13558 prep of,diagrams
R9382 T13560 T13561 compound WWOX,structure
R9383 T13561 T13559 pobj structure,of
R9384 T13562 T13558 cc and,diagrams
R9385 T13563 T13564 poss its,role
R9386 T13564 T13558 conj role,diagrams
R9387 T13565 T13564 prep in,role
R9388 T13566 T13565 pcomp signaling,in
R9389 T13567 T13558 punct .,diagrams
R9390 T13568 T13569 nsubj WWOX,contains
R9391 T13569 T13569 ROOT contains,contains
R9392 T13570 T13573 nummod two,domains
R9393 T13571 T13573 amod N-terminal,domains
R9394 T13572 T13573 compound WW,domains
R9395 T13573 T13569 dobj domains,contains
R9396 T13574 T13573 punct ",",domains
R9397 T13575 T13579 det a,dehydrogenase/reductase
R9398 T13576 T13579 amod C-terminal,dehydrogenase/reductase
R9399 T13577 T13579 compound short-chain,dehydrogenase/reductase
R9400 T13578 T13579 compound alcohol,dehydrogenase/reductase
R9401 T13579 T13573 appos dehydrogenase/reductase,domains
R9402 T13580 T13581 punct (,SDR
R9403 T13581 T13579 appos SDR,dehydrogenase/reductase
R9404 T13582 T13581 punct ),SDR
R9405 T13583 T13579 conj domain,dehydrogenase/reductase
R9406 T13584 T13583 punct ",",domain
R9407 T13585 T13583 cc and,domain
R9408 T13586 T13588 det a,region
R9409 T13587 T13588 amod D3,region
R9410 T13588 T13583 conj region,domain
R9411 T13589 T13569 punct .,contains
R9412 T13590 T13593 det A,signal
R9413 T13591 T13592 amod nuclear,localization
R9414 T13592 T13593 compound localization,signal
R9415 T13593 T13597 nsubj signal,is
R9416 T13594 T13593 punct (,signal
R9417 T13595 T13593 appos NLS,signal
R9418 T13596 T13593 punct ),signal
R9419 T13597 T13776 ccomp is,al.
R9420 T13598 T13597 prep in,is
R9421 T13599 T13598 prep between,in
R9422 T13600 T13602 det the,domains
R9423 T13601 T13602 compound WW,domains
R9424 T13602 T13599 pobj domains,between
R9425 T13603 T13606 punct (,al.
R9426 T13604 T13606 compound Chang,al.
R9427 T13605 T13606 nmod et,al.
R9428 T13606 T13776 ccomp al.,al.
R9429 T13607 T13606 punct ",",al.
R9430 T13608 T13606 appos 2003,al.
R9431 T13609 T13608 punct ",",2003
R9432 T13610 T13608 conj 2007,2003
R9433 T13611 T13776 punct ;,al.
R9434 T13612 T13613 compound Del,Mare
R9435 T13613 T13615 compound Mare,al.
R9436 T13614 T13615 nmod et,al.
R9437 T13615 T13776 ccomp al.,al.
R9438 T13616 T13615 punct ",",al.
R9439 T13617 T13615 npadvmod 2011,al.
R9440 T13618 T13615 punct ;,al.
R9441 T13619 T13621 compound Salah,al.
R9442 T13620 T13621 nmod et,al.
R9443 T13621 T13615 conj al.,al.
R9444 T13622 T13621 punct ",",al.
R9445 T13623 T13621 npadvmod 2012,al.
R9446 T13624 T13776 punct ;,al.
R9447 T13625 T13776 compound Su,al.
R9448 T13626 T13776 nmod et,al.
R9492 T13776 T13776 ROOT al.,al.
R9493 T13777 T13776 punct ",",al.
R9494 T13778 T13776 npadvmod 2012,al.
R9495 T13779 T13780 punct ;,reviews
R9496 T13780 T13776 appos reviews,al.
R9497 T13781 T13780 punct ),reviews
R9498 T13782 T13776 punct .,al.
R9499 T13783 T13785 det The,domain
R9500 T13784 T13785 compound SDR,domain
R9501 T13785 T13786 nsubj domain,possesses
R9502 T13786 T13786 ROOT possesses,possesses
R9503 T13787 T13789 det a,region
R9504 T13788 T13789 amod mitochondria-binding,region
R9505 T13789 T13786 dobj region,possesses
R9506 T13790 T13786 punct .,possesses
R9507 T13791 T13792 expl There,are
R9508 T13792 T13792 ROOT are,are
R9509 T13793 T13797 nummod two,sites
R9510 T13794 T13797 amod conserved,sites
R9511 T13795 T13797 amod tyrosine,sites
R9512 T13796 T13797 compound phosphorylation,sites
R9513 T13797 T13792 attr sites,are
R9514 T13798 T13797 punct ",",sites
R9515 T13799 T13797 appos Tyr33,sites
R9516 T13800 T13799 cc and,Tyr33
R9517 T13801 T13799 conj Tyr287,Tyr33
R9518 T13802 T13792 punct .,are
R9519 T13803 T13805 amod Other,sites
R9520 T13804 T13805 compound phosphorylation,sites
R9521 T13805 T13811 nsubj sites,are
R9522 T13806 T13805 acl predicted,sites
R9523 T13807 T13806 agent by,predicted
R9524 T13808 T13810 nmod NetPhos,Server
R9525 T13809 T13810 nummod 2.0,Server
R9526 T13810 T13807 pobj Server,by
R9527 T13811 T13811 ROOT are,are
R9528 T13812 T13811 attr Tyr6,are
R9529 T13813 T13812 punct ",",Tyr6
R9530 T13814 T13812 conj Thr12,Tyr6
R9531 T13815 T13814 punct ",",Thr12
R9532 T13816 T13814 conj Ser14,Thr12
R9533 T13817 T13816 punct ",",Ser14
R9534 T13818 T13816 conj Tyr61,Ser14
R9535 T13819 T13818 punct ",",Tyr61
R9536 T13820 T13818 conj Tyr293,Tyr61
R9537 T13821 T13820 punct ",",Tyr293
R9538 T13822 T13820 cc and,Tyr293
R9539 T13823 T13820 conj Thr3B3,Tyr293
R9540 T13824 T13823 punct ",",Thr3B3
R9541 T13825 T13811 advmod respectively,are
R9542 T13826 T13811 punct .,are
R9543 T13827 T13833 prep Upon,phosphorylated
R9544 T13828 T13829 compound stress,stimulation
R9545 T13829 T13827 pobj stimulation,Upon
R9546 T13830 T13833 punct ",",phosphorylated
R9547 T13831 T13832 nsubj WWOX,is
R9548 T13832 T13833 auxpass is,phosphorylated
R9549 T13833 T13833 ROOT phosphorylated,phosphorylated
R9550 T13834 T13833 prep in,phosphorylated
R9551 T13835 T13834 pobj Tyr33,in
R9552 T13836 T13833 cc and,phosphorylated
R9553 T13837 T13833 conj binds,phosphorylated
R9554 T13838 T13837 dobj p53,binds
R9555 T13839 T13833 punct .,phosphorylated
R9556 T13840 T13842 det The,complex
R9557 T13841 T13842 amod WWOX/p53,complex
R9558 T13842 T13844 nsubj complex,translocates
R9559 T13843 T13844 advmod then,translocates
R9560 T13844 T13844 ROOT translocates,translocates
R9561 T13845 T13846 aux to,mitochondria
R9562 T13846 T13844 xcomp mitochondria,translocates
R9563 T13847 T13846 cc or,mitochondria
R9564 T13848 T13846 conj nucleus,mitochondria
R9565 T13849 T13850 aux to,induce
R9566 T13850 T13848 advcl induce,nucleus
R9567 T13851 T13850 dobj apoptosis,induce
R9568 T13852 T13844 punct .,translocates
R9569 T13853 T13855 nsubj WWOX,binds
R9570 T13854 T13855 advmod also,binds
R9571 T13855 T13855 ROOT binds,binds
R9572 T13856 T13859 compound PPxY,factors
R9573 T13857 T13858 compound motif-containing,transcription
R9574 T13858 T13859 compound transcription,factors
R9575 T13859 T13855 dobj factors,binds
R9576 T13860 T13859 punct ",",factors
R9577 T13861 T13862 amod such,as
R9578 T13862 T13859 prep as,factors
R9579 T13863 T13862 pobj RUNX2,as
R9580 T13864 T13863 punct ",",RUNX2
R9581 T13865 T13863 conj c-Jun,RUNX2
R9582 T13866 T13865 punct ",",c-Jun
R9583 T13867 T13865 cc and,c-Jun
R9584 T13868 T13865 conj ERBB4,c-Jun
R9585 T13869 T13859 punct ",",factors
R9586 T13870 T13855 prep via,binds
R9587 T13871 T13874 poss its,domain
R9588 T13872 T13874 amod first,domain
R9589 T13873 T13874 compound WW,domain
R9590 T13874 T13870 pobj domain,via
R9591 T13875 T13855 punct ",",binds
R9592 T13876 T13855 cc and,binds
R9593 T13877 T13879 det the,blocks
R9594 T13878 T13879 amod binding,blocks
R9595 T13879 T13855 conj blocks,binds
R9596 T13880 T13881 det the,activity
R9597 T13881 T13879 dobj activity,blocks
R9598 T13882 T13881 prep of,activity
R9599 T13883 T13884 det these,proteins
R9600 T13884 T13882 pobj proteins,of
R9601 T13885 T13879 prep by,blocks
R9602 T13886 T13885 pcomp retaining,by
R9603 T13887 T13886 dobj them,retaining
R9604 T13888 T13886 prep in,retaining
R9605 T13889 T13890 det the,cytoplasm
R9606 T13890 T13888 pobj cytoplasm,in
R9607 T13891 T13855 punct .,binds
R9608 T13892 T13893 nsubj WWOX,binds
R9609 T13893 T13893 ROOT binds,binds
R9610 T13894 T13893 dobj Tau,binds
R9611 T13895 T13893 prep via,binds
R9612 T13896 T13898 poss its,domain
R9613 T13897 T13898 compound SDR,domain
R9614 T13898 T13895 pobj domain,via
R9615 T13899 T13893 punct .,binds
R9616 T13900 T13901 nsubj WWOX,participates
R9617 T13901 T13901 ROOT participates,participates
R9618 T13902 T13901 prep in,participates
R9619 T13903 T13908 det the,pathway
R9620 T13904 T13908 nmod Wnt,pathway
R9621 T13905 T13908 nmod /,pathway
R9622 T13906 T13908 amod β-catenin,pathway
R9623 T13907 T13908 compound signal,pathway
R9624 T13908 T13902 pobj pathway,in
R9625 T13909 T13901 prep by,participates
R9626 T13910 T13911 amod binding,Dvl
R9627 T13911 T13909 pobj Dvl,by
R9628 T13912 T13901 cc and,participates
R9629 T13913 T13901 conj inhibiting,participates
R9630 T13914 T13916 poss its,import
R9631 T13915 T13916 amod nuclear,import
R9632 T13916 T13913 dobj import,inhibiting
R9633 T13917 T13901 punct .,participates
R9634 T13918 T13919 compound Phorbol,ester
R9635 T13919 T13920 nsubj ester,stimulates
R9636 T13920 T13920 ROOT stimulates,stimulates
R9637 T13921 T13922 det the,dissociation
R9638 T13922 T13920 dobj dissociation,stimulates
R9639 T13923 T13922 prep of,dissociation
R9640 T13924 T13925 compound MEK/WWOX,complex
R9641 T13925 T13923 pobj complex,of
R9642 T13926 T13922 prep in,dissociation
R9643 T13927 T13928 compound Jurkat,T
R9644 T13928 T13929 compound T,cell
R9645 T13929 T13926 pobj cell,in
R9646 T13930 T13920 punct ",",stimulates
R9647 T13931 T13920 cc and,stimulates
R9648 T13932 T13935 det the,translocates
R9649 T13933 T13935 amod released,translocates
R9650 T13934 T13935 compound WWOX,translocates
R9651 T13935 T13920 conj translocates,stimulates
R9652 T13936 T13935 prep to,translocates
R9653 T13937 T13938 det the,mitochondria
R9654 T13938 T13936 pobj mitochondria,to
R9655 T13939 T13935 prep for,translocates
R9656 T13940 T13939 pcomp causing,for
R9657 T13941 T13942 compound cell,death
R9658 T13942 T13940 dobj death,causing
R9659 T13943 T13920 punct .,stimulates
R9660 T13944 T13946 nsubjpass WWOX,recruited
R9661 T13945 T13946 auxpass is,recruited
R9662 T13946 T13946 ROOT recruited,recruited
R9663 T13947 T13946 prep to,recruited
R9664 T13948 T13950 det the,area
R9665 T13949 T13950 compound membrane,area
R9666 T13950 T13947 pobj area,to
R9667 T13951 T13946 agent by,recruited
R9668 T13952 T13951 pobj association,by
R9669 T13953 T13952 prep with,association
R9670 T13954 T13953 pobj Hyal-2,with
R9671 T13955 T13954 cc and,Hyal-2
R9672 T13956 T13954 conj phospho-Ezrin,Hyal-2
R9673 T13957 T13946 punct .,recruited
R9674 T13958 T13959 nsubj Hyal-2,is
R9675 T13959 T13959 ROOT is,is
R9676 T13960 T13962 det an,receptor
R9677 T13961 T13962 amod alternative,receptor
R9678 T13962 T13959 attr receptor,is
R9679 T13963 T13962 prep for,receptor
R9680 T13964 T13963 pobj TGF-β1,for
R9951 T14525 T14525 ROOT p53,p53
R9952 T14526 T14525 cc and,p53
R9953 T14527 T14525 conj WWOX,p53
R9954 T14528 T14527 prep in,WWOX
R9955 T14529 T14531 compound GBM,apoptosis
R9956 T14530 T14531 compound cell,apoptosis
R9957 T14531 T14528 pobj apoptosis,in
R9958 T14532 T14525 punct .,p53
R9959 T14533 T14538 punct (,possesses
R9960 T14534 T14537 det A,p53
R9961 T14535 T14537 punct ),p53
R9962 T14536 T14537 amod Full-length,p53
R9963 T14537 T14538 nsubj p53,possesses
R9964 T14538 T14538 ROOT possesses,possesses
R9965 T14539 T14543 nummod two,domains
R9966 T14540 T14543 amod N-terminal,domains
R9967 T14541 T14543 amod transactivation,domains
R9968 T14542 T14543 amod acidic,domains
R9969 T14543 T14538 dobj domains,possesses
R9970 T14544 T14543 punct ",",domains
R9971 T14545 T14547 det a,domain
R9972 T14546 T14547 amod proline-rich,domain
R9973 T14547 T14543 appos domain,domains
R9974 T14548 T14547 punct ",",domain
R9975 T14549 T14552 det a,region
R9976 T14550 T14552 amod central,region
R9977 T14551 T14552 amod DNA-binding,region
R9978 T14552 T14547 conj region,domain
R9979 T14553 T14547 punct ",",domain
R9980 T14554 T14547 cc and,domain
R9981 T14555 T14557 det a,domain
R9982 T14556 T14557 amod C-terminal,domain
R9983 T14557 T14547 conj domain,domain
R9984 T14558 T14557 punct ",",domain
R9985 T14559 T14557 acl containing,domain
R9986 T14560 T14563 det a,signal
R9987 T14561 T14562 amod nuclear,localization
R9988 T14562 T14563 compound localization,signal
R9989 T14563 T14559 dobj signal,containing
R9990 T14564 T14563 punct ",",signal
R9991 T14565 T14567 det an,domain
R9992 T14566 T14567 compound oligomerization,domain
R9993 T14567 T14563 conj domain,signal
R9994 T14568 T14567 punct ",",domain
R9995 T14569 T14567 cc and,domain
R9996 T14570 T14572 det a,region
R9997 T14571 T14572 amod basic,region
R9998 T14572 T14567 conj region,domain
R9999 T14573 T14538 punct .,possesses