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PMC:3359311 / 17809-25533 JSONTXT 16 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7430 11-17 NNS denotes Levels
T7431 18-20 IN denotes of
T7432 21-26 NN denotes IL-1β
T7433 27-30 VBP denotes are
T7434 31-40 VBN denotes increased
T7435 41-43 IN denotes in
T7436 44-47 DT denotes the
T7437 48-52 NNP denotes BALF
T7438 53-55 IN denotes of
T7439 56-58 NNP denotes CF
T7440 59-67 NNS denotes patients
T7441 68-71 CC denotes but
T7442 72-75 DT denotes the
T7443 76-84 JJ denotes cellular
T7444 85-91 NN denotes source
T7445 92-94 IN denotes of
T7446 95-99 DT denotes this
T7447 100-108 NN denotes cytokine
T7448 109-112 CC denotes and
T7449 113-116 PRP$ denotes its
T7450 117-127 NN denotes production
T7451 128-130 IN denotes in
T7452 131-134 DT denotes the
T7453 135-142 NN denotes context
T7454 143-145 IN denotes of
T7455 146-154 JJ denotes targeted
T7456 155-167 JJ denotes inflammasome
T7457 168-178 NN denotes activation
T7458 179-182 VBP denotes are
T7459 183-188 RB denotes still
T7460 189-196 JJ denotes unclear
T7461 196-197 . denotes .
T7462 198-200 PRP denotes We
T7463 201-206 RB denotes first
T7464 207-214 VBD denotes studied
T7465 215-221 NN denotes airway
T7466 222-232 JJ denotes epithelial
T7467 233-238 NNS denotes cells
T7468 239-242 JJ denotes due
T7469 243-245 TO denotes to
T7470 246-251 PRP$ denotes their
T7471 252-256 NN denotes role
T7472 257-259 IN denotes in
T7473 260-267 NN denotes barrier
T7474 268-276 NN denotes function
T7475 276-277 , denotes ,
T7476 278-287 NN denotes proximity
T7477 288-290 TO denotes to
T7478 291-300 NN denotes infection
T7479 300-301 , denotes ,
T7480 302-305 CC denotes and
T7481 306-313 NN denotes ability
T7482 314-316 TO denotes to
T7483 317-324 VB denotes produce
T7484 325-329 JJ denotes high
T7485 330-336 NNS denotes levels
T7486 337-339 IN denotes of
T7487 340-356 JJ denotes pro-inflammatory
T7488 357-366 NNS denotes cytokines
T7489 366-367 . denotes .
T7490 368-375 RB denotes However
T7491 375-376 , denotes ,
T7492 377-379 PRP denotes we
T7493 380-385 VBD denotes found
T7494 386-390 IN denotes that
T7495 391-400 JJ denotes bronchial
T7496 401-411 JJ denotes epithelial
T7497 412-417 NNS denotes cells
T7498 418-420 VBP denotes do
T7499 421-424 RB denotes not
T7500 425-432 VB denotes produce
T7501 433-444 JJ denotes significant
T7502 445-452 NNS denotes amounts
T7503 453-455 IN denotes of
T7504 456-461 NN denotes IL-1β
T7505 462-465 CC denotes and
T7506 466-468 VB denotes do
T7507 469-472 RB denotes not
T7508 473-477 VB denotes show
T7509 478-479 DT denotes a
T7510 480-491 JJ denotes significant
T7511 492-500 NN denotes increase
T7512 501-503 IN denotes in
T7513 504-513 JJ denotes caspase-1
T7514 514-524 NN denotes activation
T7515 525-527 IN denotes in
T7516 528-536 NN denotes response
T7517 537-539 TO denotes to
T7518 540-544 CD denotes PAO1
T7519 545-548 CC denotes and
T7520 549-556 NNP denotes LPS+ATP
T7521 556-557 , denotes ,
T7522 558-560 IN denotes in
T7523 561-571 NN denotes comparison
T7524 572-574 TO denotes to
T7525 575-588 JJ denotes hematopoeitic
T7526 589-600 NN denotes mononuclear
T7527 601-606 NNS denotes cells
T7528 606-607 . denotes .
T7529 608-633 JJ denotes Hematopoeitically-derived
T7530 634-639 NNS denotes cells
T7531 639-640 , denotes ,
T7532 641-645 JJ denotes such
T7533 646-648 IN denotes as
T7534 649-658 NNS denotes monocytes
T7535 659-662 CC denotes and
T7536 663-674 NNS denotes macrophages
T7537 674-675 , denotes ,
T7538 676-682 VBP denotes appear
T7539 683-685 TO denotes to
T7540 686-688 VB denotes be
T7541 689-690 DT denotes a
T7542 691-700 JJ denotes principal
T7543 701-707 NN denotes source
T7544 708-710 IN denotes of
T7545 711-716 NN denotes IL-1β
T7546 716-717 . denotes .
T7547 718-722 NNP denotes CFTR
T7548 723-725 VBZ denotes is
T7549 726-735 VBN denotes expressed
T7550 736-738 IN denotes in
T7551 739-747 JJ denotes alveolar
T7552 748-759 NNS denotes macrophages
T7553 760-761 NNP denotes [
T7554 761-763 CD denotes 32
T7555 763-764 NNP denotes ]
T7556 764-765 , denotes ,
T7557 766-767 NNP denotes [
T7558 767-769 CD denotes 39
T7559 769-770 NNP denotes ]
T7560 771-773 RB denotes as
T7561 774-778 RB denotes well
T7562 779-781 IN denotes as
T7563 782-784 IN denotes in
T7564 785-790 NNP denotes PBMCs
T7565 791-793 IN denotes at
T7566 794-798 DT denotes both
T7567 799-802 DT denotes the
T7568 803-807 NNP denotes mRNA
T7569 808-811 CC denotes and
T7570 812-819 NN denotes protein
T7571 820-825 NN denotes level
T7572 826-827 NNP denotes [
T7573 827-829 CD denotes 40
T7574 829-830 NNP denotes ]
T7575 830-831 , denotes ,
T7576 832-833 NNP denotes [
T7577 833-835 CD denotes 41
T7578 835-836 NNP denotes ]
T7579 836-837 , denotes ,
T7580 838-841 CC denotes and
T7581 842-845 PRP$ denotes its
T7582 846-850 NN denotes loss
T7583 851-853 VBZ denotes is
T7584 854-864 RB denotes frequently
T7585 865-875 VBN denotes associated
T7586 876-880 IN denotes with
T7587 881-883 DT denotes an
T7588 884-893 JJ denotes augmented
T7589 894-906 JJ denotes inflammatory
T7590 907-916 NN denotes phenotype
T7591 916-917 . denotes .
T7592 918-925 IN denotes Despite
T7593 926-929 PRP$ denotes our
T7594 930-938 NNS denotes findings
T7595 939-949 VBG denotes indicating
T7596 950-954 IN denotes that
T7597 955-964 JJ denotes bronchial
T7598 965-975 JJ denotes epithelial
T7599 976-981 NNS denotes cells
T7600 982-986 WRB denotes when
T7601 987-992 VBN denotes grown
T7602 993-995 IN denotes in
T7603 996-1001 NN denotes vitro
T7604 1002-1005 VBP denotes are
T7605 1006-1014 JJ denotes unlikely
T7606 1015-1017 TO denotes to
T7607 1018-1020 VB denotes be
T7608 1021-1034 RB denotes significantly
T7609 1035-1043 VBN denotes involved
T7610 1044-1046 IN denotes in
T7611 1047-1050 DT denotes the
T7612 1051-1057 JJ denotes direct
T7613 1058-1068 NN denotes production
T7614 1069-1071 IN denotes of
T7615 1072-1077 NNP denotes IL-1β
T7616 1078-1079 -LRB- denotes (
T7617 1079-1083 NNP denotes Fig.
T7618 1084-1086 CD denotes 2a
T7619 1087-1088 LS denotes d
T7620 1088-1089 -RRB- denotes )
T7621 1089-1090 , denotes ,
T7622 1091-1097 NNS denotes others
T7623 1098-1102 VBP denotes have
T7624 1103-1108 VBN denotes shown
T7625 1109-1114 PRP$ denotes their
T7626 1115-1123 NN denotes capacity
T7627 1124-1126 TO denotes to
T7628 1127-1134 VB denotes respond
T7629 1135-1137 TO denotes to
T7630 1138-1146 JJ denotes alveolar
T7631 1147-1165 JJ denotes macrophage-derived
T7632 1166-1171 NN denotes IL-1β
T7633 1172-1175 CC denotes and
T7634 1176-1178 TO denotes to
T7635 1179-1186 VB denotes amplify
T7636 1187-1190 DT denotes the
T7637 1191-1203 JJ denotes inflammatory
T7638 1204-1212 NN denotes response
T7639 1213-1220 IN denotes through
T7640 1221-1224 DT denotes the
T7641 1225-1234 NN denotes induction
T7642 1235-1237 IN denotes of
T7643 1238-1248 NNS denotes chemokines
T7644 1249-1252 CC denotes and
T7645 1253-1264 NN denotes recruitment
T7646 1265-1267 IN denotes of
T7647 1268-1280 JJ denotes inflammatory
T7648 1281-1289 NN denotes effector
T7649 1290-1295 NNS denotes cells
T7650 1296-1297 NNP denotes [
T7651 1297-1299 CD denotes 42
T7652 1299-1300 NNP denotes ]
T7653 1300-1301 . denotes .
T7654 1302-1306 DT denotes This
T7655 1307-1318 NN denotes interaction
T7656 1319-1322 MD denotes may
T7657 1323-1333 VB denotes constitute
T7658 1334-1335 DT denotes a
T7659 1336-1344 JJ denotes critical
T7660 1345-1354 NN denotes component
T7661 1355-1357 TO denotes to
T7662 1358-1367 JJ denotes effective
T7663 1368-1372 NN denotes host
T7664 1373-1380 NN denotes defense
T7665 1381-1384 CC denotes and
T7666 1385-1396 VBG denotes diminishing
T7667 1397-1400 DT denotes the
T7668 1401-1409 NN denotes capacity
T7669 1410-1412 IN denotes of
T7670 1413-1417 NN denotes host
T7671 1418-1423 NNS denotes cells
T7672 1424-1426 TO denotes to
T7673 1427-1434 VB denotes respond
T7674 1435-1437 TO denotes to
T7675 1438-1443 NNP denotes IL-1β
T7676 1444-1447 MD denotes may
T7677 1448-1453 VB denotes leave
T7678 1454-1457 DT denotes the
T7679 1458-1462 NN denotes host
T7680 1463-1474 JJ denotes susceptible
T7681 1475-1477 TO denotes to
T7682 1478-1488 NNS denotes infections
T7683 1489-1491 IN denotes by
T7684 1492-1501 NNS denotes pathogens
T7685 1502-1506 JJ denotes such
T7686 1507-1509 IN denotes as
T7687 1510-1512 NNP denotes P.
T7688 1513-1523 NN denotes aeruginosa
T7689 1524-1525 NNP denotes [
T7690 1525-1527 CD denotes 43
T7691 1527-1528 NNP denotes ]
T7692 1528-1529 . denotes .
T7693 1530-1540 RB denotes Conversely
T7694 1540-1541 , denotes ,
T7695 1542-1556 NN denotes overproduction
T7696 1557-1559 IN denotes of
T7697 1560-1565 NN denotes IL-1β
T7698 1566-1569 MD denotes can
T7699 1570-1574 RB denotes also
T7700 1575-1579 VB denotes play
T7701 1580-1581 DT denotes a
T7702 1582-1585 JJ denotes key
T7703 1586-1590 NN denotes role
T7704 1591-1593 IN denotes in
T7705 1594-1601 JJ denotes chronic
T7706 1602-1614 JJ denotes inflammatory
T7707 1615-1624 NNS denotes responses
T7708 1625-1628 CC denotes and
T7709 1629-1634 NN denotes cause
T7710 1635-1641 NN denotes damage
T7711 1642-1644 TO denotes to
T7712 1645-1648 DT denotes the
T7713 1649-1653 NN denotes lung
T7714 1654-1664 NN denotes parenchyma
T7715 1665-1666 NNP denotes [
T7716 1666-1668 CD denotes 44
T7717 1668-1669 NNP denotes ]
T7718 1669-1670 , denotes ,
T7719 1671-1672 NNP denotes [
T7720 1672-1674 CD denotes 45
T7721 1674-1675 NNP denotes ]
T7722 1675-1676 . denotes .
T7723 1677-1685 IN denotes Although
T7724 1686-1688 PRP denotes we
T7725 1689-1701 VBD denotes hypothesized
T7726 1702-1706 IN denotes that
T7727 1707-1709 NNP denotes CF
T7728 1710-1715 NNS denotes cells
T7729 1716-1721 MD denotes would
T7730 1722-1729 VB denotes secrete
T7731 1730-1739 JJ denotes increased
T7732 1740-1747 NNS denotes amounts
T7733 1748-1750 IN denotes of
T7734 1751-1756 NN denotes IL-1β
T7735 1756-1757 , denotes ,
T7736 1758-1760 PRP denotes we
T7737 1761-1766 VBD denotes found
T7738 1767-1771 IN denotes that
T7739 1772-1777 JJ denotes IL-1β
T7740 1778-1788 NN denotes production
T7741 1789-1791 IN denotes in
T7742 1792-1794 NNP denotes CF
T7743 1795-1800 NNP denotes PBMCs
T7744 1801-1804 VBD denotes was
T7745 1805-1808 RB denotes not
T7746 1809-1818 VBN denotes increased
T7747 1819-1823 IN denotes upon
T7748 1824-1836 JJ denotes inflammasome
T7749 1837-1848 NN denotes stimulation
T7750 1849-1851 IN denotes as
T7751 1852-1860 VBN denotes compared
T7752 1861-1863 TO denotes to
T7753 1864-1872 NNS denotes controls
T7754 1873-1874 -LRB- denotes (
T7755 1874-1878 NNP denotes Fig.
T7756 1879-1881 CD denotes 5a
T7757 1882-1883 NN denotes b
T7758 1883-1884 -RRB- denotes )
T7759 1884-1885 . denotes .
T7760 1886-1890 DT denotes This
T7761 1891-1894 VBD denotes was
T7762 1895-1897 IN denotes in
T7763 1898-1906 NN denotes contrast
T7764 1907-1909 TO denotes to
T7765 1910-1911 DT denotes a
T7766 1912-1920 JJ denotes previous
T7767 1921-1926 NN denotes study
T7768 1927-1931 IN denotes from
T7769 1932-1935 PRP$ denotes our
T7770 1936-1941 NN denotes group
T7771 1941-1942 , denotes ,
T7772 1943-1948 WDT denotes which
T7773 1949-1955 VBD denotes showed
T7774 1956-1965 VBN denotes increased
T7775 1966-1971 JJ denotes IL-1β
T7776 1972-1982 NN denotes production
T7777 1983-1985 IN denotes by
T7778 1986-1988 NNP denotes CF
T7779 1989-1994 NNP denotes PBMCs
T7780 1995-1997 IN denotes in
T7781 1998-2006 NN denotes response
T7782 2007-2009 TO denotes to
T7783 2010-2013 NNP denotes LPS
T7784 2014-2015 NNP denotes [
T7785 2015-2017 CD denotes 46
T7786 2017-2018 NNP denotes ]
T7787 2018-2019 , denotes ,
T7788 2020-2028 IN denotes although
T7789 2029-2033 DT denotes this
T7790 2034-2044 NN denotes difference
T7791 2045-2048 MD denotes may
T7792 2049-2051 VB denotes be
T7793 2052-2061 VBN denotes accounted
T7794 2062-2065 IN denotes for
T7795 2066-2068 IN denotes by
T7796 2069-2078 JJ denotes technical
T7797 2079-2085 NNS denotes issues
T7798 2086-2088 IN denotes in
T7799 2089-2100 NN denotes stimulation
T7800 2101-2105 NN denotes time
T7801 2106-2109 CC denotes and
T7802 2110-2114 NN denotes dose
T7803 2114-2115 . denotes .
T7804 2116-2124 RB denotes Moreover
T7805 2124-2125 , denotes ,
T7806 2126-2131 JJ denotes IL-1β
T7807 2132-2142 NN denotes production
T7808 2143-2146 VBD denotes was
T7809 2147-2150 RB denotes not
T7810 2151-2160 VBN denotes increased
T7811 2161-2163 IN denotes in
T7812 2164-2166 NNP denotes CF
T7813 2167-2172 NNP denotes PBMCs
T7814 2173-2177 IN denotes with
T7815 2178-2190 JJ denotes inflammasome
T7816 2191-2202 NN denotes stimulation
T7817 2203-2208 RB denotes alone
T7818 2209-2211 RB denotes as
T7819 2212-2217 MD denotes would
T7820 2218-2220 VB denotes be
T7821 2221-2232 VBN denotes anticipated
T7822 2233-2235 IN denotes if
T7823 2236-2241 EX denotes there
T7824 2242-2246 VBD denotes were
T7825 2247-2252 JJ denotes basal
T7826 2253-2259 NNS denotes levels
T7827 2260-2262 IN denotes of
T7828 2263-2268 JJ denotes NF-κB
T7829 2269-2279 NN denotes activation
T7830 2279-2280 . denotes .
T7831 2281-2286 NNS denotes Cells
T7832 2287-2296 VBP denotes deficient
T7833 2297-2299 IN denotes in
T7834 2300-2304 NNP denotes CFTR
T7835 2305-2308 VBP denotes are
T7836 2309-2316 VBN denotes thought
T7837 2317-2319 TO denotes to
T7838 2320-2327 VB denotes exhibit
T7839 2328-2330 DT denotes an
T7840 2331-2340 VBN denotes increased
T7841 2341-2346 JJ denotes basal
T7842 2347-2352 NN denotes level
T7843 2353-2355 IN denotes of
T7844 2356-2361 JJ denotes NF-κB
T7845 2362-2370 NN denotes activity
T7846 2370-2371 , denotes ,
T7847 2372-2377 WDT denotes which
T7848 2378-2383 VBZ denotes leads
T7849 2384-2386 TO denotes to
T7850 2387-2396 VBN denotes increased
T7851 2397-2413 JJ denotes pro-inflammatory
T7852 2414-2422 NN denotes cytokine
T7853 2423-2433 NN denotes production
T7854 2434-2443 VBG denotes including
T7855 2444-2446 DT denotes an
T7856 2447-2456 JJ denotes increased
T7857 2457-2469 NN denotes availability
T7858 2470-2472 IN denotes of
T7859 2473-2482 NN denotes pro-IL-1β
T7860 2483-2486 IN denotes for
T7861 2487-2495 NN denotes cleavage
T7862 2496-2499 CC denotes and
T7863 2500-2509 NN denotes secretion
T7864 2509-2510 . denotes .
T7865 2511-2515 DT denotes This
T7866 2516-2529 NN denotes amplification
T7867 2530-2532 IN denotes of
T7868 2533-2538 JJ denotes IL-1β
T7869 2539-2548 NN denotes secretion
T7870 2549-2552 VBD denotes was
T7871 2553-2558 VBN denotes shown
T7872 2559-2561 IN denotes by
T7873 2562-2569 VBG denotes priming
T7874 2570-2575 CD denotes THP-1
T7875 2576-2585 NNS denotes monocytes
T7876 2586-2589 CC denotes and
T7877 2590-2595 NNS denotes PBMCs
T7878 2596-2600 IN denotes with
T7879 2601-2612 JJ denotes heat-killed
T7880 2613-2615 NNP denotes P.
T7881 2616-2626 NN denotes aeruginosa
T7882 2627-2629 CC denotes or
T7883 2630-2633 NNP denotes LPS
T7884 2634-2639 RB denotes prior
T7885 2640-2642 TO denotes to
T7886 2643-2654 NN denotes stimulation
T7887 2655-2659 IN denotes with
T7888 2660-2664 JJ denotes live
T7889 2665-2667 NNP denotes P.
T7890 2668-2678 NN denotes aeruginosa
T7891 2678-2679 . denotes .
T7892 2680-2684 DT denotes This
T7893 2685-2697 RB denotes dramatically
T7894 2698-2707 VBN denotes increased
T7895 2708-2713 JJ denotes IL-1β
T7896 2714-2723 NN denotes secretion
T7897 2724-2728 IN denotes over
T7898 2729-2740 NN denotes stimulation
T7899 2741-2745 IN denotes with
T7900 2746-2750 JJ denotes live
T7901 2751-2753 NNP denotes P.
T7902 2754-2764 NN denotes aeruginosa
T7903 2765-2772 IN denotes without
T7904 2773-2780 NN denotes priming
T7905 2781-2782 -LRB- denotes (
T7906 2782-2786 NNP denotes Fig.
T7907 2787-2789 CD denotes 6c
T7908 2789-2790 -RRB- denotes )
T7909 2790-2791 . denotes .
T7910 2792-2801 RB denotes Similarly
T7911 2801-2802 , denotes ,
T7912 2803-2805 IN denotes if
T7913 2806-2808 NNP denotes CF
T7914 2809-2814 NNP denotes PBMCs
T7915 2815-2824 VBD denotes expressed
T7916 2825-2834 VBN denotes increased
T7917 2835-2840 JJ denotes basal
T7918 2841-2846 NN denotes NF-κB
T7919 2847-2855 NN denotes activity
T7920 2855-2856 , denotes ,
T7921 2857-2862 EX denotes there
T7922 2863-2868 MD denotes would
T7923 2869-2871 VB denotes be
T7924 2872-2874 DT denotes an
T7925 2875-2883 NN denotes increase
T7926 2884-2886 IN denotes in
T7927 2887-2892 JJ denotes IL-1β
T7928 2893-2902 NN denotes secretion
T7929 2903-2905 IN denotes in
T7930 2906-2909 DT denotes the
T7931 2910-2917 NN denotes absence
T7932 2918-2920 IN denotes of
T7933 2921-2924 NNP denotes LPS
T7934 2925-2932 NN denotes priming
T7935 2932-2933 . denotes .
T7936 2934-2941 RB denotes However
T7937 2941-2942 , denotes ,
T7938 2943-2945 DT denotes no
T7939 2946-2954 NN denotes increase
T7940 2955-2957 IN denotes in
T7941 2958-2963 NN denotes IL-1β
T7942 2964-2967 VBD denotes was
T7943 2968-2976 VBN denotes observed
T7944 2977-2982 IN denotes under
T7945 2983-2988 NN denotes basal
T7946 2989-2991 CC denotes or
T7947 2992-2998 VBN denotes primed
T7948 2999-3009 NNS denotes conditions
T7949 3009-3010 . denotes .
T7950 3011-3018 NNP denotes Studies
T7951 3019-3032 VBG denotes investigating
T7952 3033-3036 DT denotes the
T7953 3037-3047 NN denotes production
T7954 3048-3050 IN denotes of
T7955 3051-3056 NN denotes IL-1β
T7956 3057-3061 VBP denotes have
T7957 3062-3066 VBN denotes been
T7958 3067-3075 RB denotes somewhat
T7959 3076-3088 JJ denotes inconsistent
T7960 3088-3089 . denotes .
T7961 3090-3091 DT denotes A
T7962 3092-3097 NN denotes study
T7963 3098-3100 IN denotes by
T7964 3101-3110 NNP denotes Reininger
T7965 3111-3113 FW denotes et
T7966 3114-3117 FW denotes al.
T7967 3118-3119 NNP denotes [
T7968 3119-3121 CD denotes 43
T7969 3121-3122 NNP denotes ]
T7970 3123-3131 VBD denotes provided
T7971 3132-3140 NN denotes evidence
T7972 3141-3145 IN denotes that
T7973 3146-3151 JJ denotes human
T7974 3152-3161 JJ denotes bronchial
T7975 3162-3172 JJ denotes epithelial
T7976 3173-3178 NNS denotes cells
T7977 3179-3189 VBG denotes possessing
T7978 3190-3193 DT denotes the
T7979 3194-3199 NNP denotes ΔF508
T7980 3200-3204 NNP denotes CFTR
T7981 3205-3213 NN denotes mutation
T7982 3214-3217 VBD denotes had
T7983 3218-3219 DT denotes a
T7984 3220-3228 RB denotes slightly
T7985 3229-3236 VBN denotes reduced
T7986 3237-3245 NN denotes capacity
T7987 3246-3248 TO denotes to
T7988 3249-3256 VB denotes produce
T7989 3257-3262 JJ denotes IL-1β
T7990 3263-3266 CC denotes and
T7991 3267-3273 VBD denotes lacked
T7992 3274-3277 DT denotes the
T7993 3278-3285 NN denotes ability
T7994 3286-3288 TO denotes to
T7995 3289-3295 VB denotes induce
T7996 3296-3298 DT denotes an
T7997 3299-3304 JJ denotes early
T7998 3305-3310 NN denotes NF-κB
T7999 3311-3321 NN denotes activation
T8000 3322-3324 IN denotes in
T8001 3325-3333 NN denotes response
T8002 3334-3336 TO denotes to
T8003 3337-3339 NNP denotes P.
T8004 3340-3350 NN denotes aeruginosa
T8005 3350-3351 . denotes .
T8006 3352-3362 RB denotes Conversely
T8007 3362-3363 , denotes ,
T8008 3364-3365 DT denotes a
T8009 3366-3371 NN denotes study
T8010 3372-3374 IN denotes by
T8011 3375-3383 NNP denotes Kotrange
T8012 3384-3386 FW denotes et
T8013 3387-3390 FW denotes al.
T8014 3391-3392 NNP denotes [
T8015 3392-3394 CD denotes 31
T8016 3394-3395 NNP denotes ]
T8017 3396-3401 VBD denotes found
T8018 3402-3406 IN denotes that
T8019 3407-3413 JJ denotes murine
T8020 3414-3418 NN denotes bone
T8021 3419-3433 JJ denotes marrow-derived
T8022 3434-3445 NNS denotes macrophages
T8023 3446-3456 VBG denotes expressing
T8024 3457-3467 NN denotes ΔF508-CFTR
T8025 3468-3476 VBD denotes produced
T8026 3477-3486 VBN denotes increased
T8027 3487-3494 NNS denotes amounts
T8028 3495-3497 IN denotes of
T8029 3498-3503 NN denotes IL-1β
T8030 3504-3508 WRB denotes when
T8031 3509-3517 VBN denotes compared
T8032 3518-3520 TO denotes to
T8033 3521-3532 NNS denotes macrophages
T8034 3533-3543 VBG denotes expressing
T8035 3544-3550 JJ denotes normal
T8036 3551-3555 NNP denotes CFTR
T8037 3556-3558 IN denotes in
T8038 3559-3567 NN denotes response
T8039 3568-3570 TO denotes to
T8040 3571-3583 NNP denotes Burkholderia
T8041 3584-3595 NN denotes cenocepacia
T8042 3596-3601 NN denotes K56-2
T8043 3601-3602 . denotes .
T8044 3603-3606 DT denotes The
T8045 3607-3622 NN denotes differentiation
T8046 3623-3625 IN denotes of
T8047 3626-3635 NNS denotes monocytes
T8048 3636-3640 IN denotes into
T8049 3641-3652 NNS denotes macrophages
T8050 3653-3656 MD denotes may
T8051 3657-3663 RB denotes partly
T8052 3664-3671 VB denotes account
T8053 3672-3675 IN denotes for
T8054 3676-3679 DT denotes the
T8055 3680-3691 NNS denotes differences
T8056 3692-3700 VBD denotes observed
T8057 3701-3705 IN denotes with
T8058 3706-3709 DT denotes the
T8059 3710-3715 NN denotes study
T8060 3716-3718 IN denotes by
T8061 3719-3727 NNP denotes Kotrange
T8062 3727-3728 . denotes .
T8063 3729-3750 JJ denotes Inflammasome-mediated
T8064 3751-3756 JJ denotes IL-1β
T8065 3757-3767 NN denotes production
T8066 3768-3770 IN denotes by
T8067 3771-3780 NNS denotes monocytes
T8068 3781-3784 CC denotes and
T8069 3785-3790 NNS denotes PBMCs
T8070 3791-3795 VBZ denotes does
T8071 3796-3802 VB denotes differ
T8072 3803-3807 IN denotes from
T8073 3808-3819 NNS denotes macrophages
T8074 3820-3821 NNP denotes [
T8075 3821-3823 CD denotes 47
T8076 3823-3824 NNP denotes ]
T8077 3824-3825 , denotes ,
T8078 3826-3827 NNP denotes [
T8079 3827-3829 CD denotes 48
T8080 3829-3830 NNP denotes ]
T8081 3830-3831 , denotes ,
T8082 3832-3833 NNP denotes [
T8083 3833-3835 CD denotes 49
T8084 3835-3836 NNP denotes ]
T8085 3837-3840 CC denotes and
T8086 3841-3852 NNS denotes macrophages
T8087 3853-3856 VBP denotes are
T8088 3857-3862 VBN denotes found
T8089 3863-3865 TO denotes to
T8090 3866-3870 VB denotes have
T8091 3871-3877 JJR denotes higher
T8092 3878-3888 NN denotes expression
T8093 3889-3891 IN denotes of
T8094 3892-3896 NNP denotes CFTR
T8095 3897-3901 IN denotes over
T8096 3902-3911 NNS denotes monocytes
T8097 3912-3913 NNP denotes [
T8098 3913-3915 CD denotes 50
T8099 3915-3916 NNP denotes ]
T8100 3916-3917 . denotes .
T8101 3918-3925 RB denotes However
T8102 3925-3926 , denotes ,
T8103 3927-3929 IN denotes as
T8104 3930-3939 NNS denotes monocytes
T8105 3940-3943 CC denotes and
T8106 3944-3949 JJ denotes other
T8107 3950-3955 NNS denotes PBMCs
T8108 3956-3963 VBP denotes express
T8109 3964-3968 NNP denotes CFTR
T8110 3969-3970 NNP denotes [
T8111 3970-3972 CD denotes 50
T8112 3972-3973 NNP denotes ]
T8113 3973-3974 , denotes ,
T8114 3975-3976 NNP denotes [
T8115 3976-3978 CD denotes 51
T8116 3978-3979 NNP denotes ]
T8117 3980-3983 CC denotes and
T8118 3984-3991 VB denotes produce
T8119 3992-3997 JJ denotes large
T8120 3998-4005 NNS denotes amounts
T8121 4006-4008 IN denotes of
T8122 4009-4014 NN denotes IL-1β
T8123 4014-4015 , denotes ,
T8124 4016-4020 PRP denotes they
T8125 4021-4024 VBP denotes are
T8126 4025-4033 JJ denotes adequate
T8127 4034-4040 NNS denotes models
T8128 4041-4043 TO denotes to
T8129 4044-4051 VB denotes examine
T8130 4052-4055 DT denotes the
T8131 4056-4063 NNS denotes effects
T8132 4064-4066 IN denotes of
T8133 4067-4071 NNP denotes CFTR
T8134 4072-4080 NN denotes function
T8135 4081-4083 IN denotes on
T8136 4084-4089 JJ denotes IL-1β
T8137 4090-4100 NN denotes production
T8138 4100-4101 . denotes .
T8139 4102-4107 JJ denotes Other
T8140 4108-4121 JJ denotes hematopoeitic
T8141 4122-4127 NNS denotes cells
T8142 4128-4131 MD denotes may
T8143 4132-4136 RB denotes also
T8144 4137-4147 VB denotes contribute
T8145 4148-4150 TO denotes to
T8146 4151-4156 JJ denotes IL-1β
T8147 4157-4167 NN denotes production
T8148 4167-4168 . denotes .
T8149 4169-4172 IN denotes For
T8150 4173-4180 NN denotes example
T8151 4180-4181 , denotes ,
T8152 4182-4192 NN denotes neutrophil
T8153 4193-4199 NNS denotes counts
T8154 4200-4203 MD denotes can
T8155 4204-4206 VB denotes be
T8156 4207-4220 RB denotes significantly
T8157 4221-4230 VBN denotes increased
T8158 4231-4233 IN denotes in
T8159 4234-4237 DT denotes the
T8160 4238-4243 NNS denotes lungs
T8161 4244-4246 IN denotes of
T8162 4247-4249 NNP denotes CF
T8163 4250-4258 NNS denotes patients
T8164 4259-4260 NNP denotes [
T8165 4260-4262 CD denotes 52
T8166 4262-4263 NNP denotes ]
T8167 4263-4264 , denotes ,
T8168 4265-4266 NNP denotes [
T8169 4266-4268 CD denotes 53
T8170 4268-4269 NNP denotes ]
T8171 4269-4270 , denotes ,
T8172 4271-4272 NNP denotes [
T8173 4272-4274 CD denotes 54
T8174 4274-4275 NNP denotes ]
T8175 4276-4279 CC denotes and
T8176 4280-4283 MD denotes may
T8177 4284-4291 VB denotes produce
T8178 4292-4298 JJ denotes mature
T8179 4299-4304 NN denotes IL-1β
T8180 4305-4312 IN denotes through
T8181 4313-4322 JJ denotes caspase-1
T8182 4323-4334 JJ denotes independent
T8183 4335-4345 NNS denotes mechanisms
T8184 4346-4347 NNP denotes [
T8185 4347-4349 CD denotes 55
T8186 4349-4350 NNP denotes ]
T8187 4350-4351 . denotes .
T8188 4352-4355 DT denotes The
T8189 4356-4360 NN denotes role
T8190 4361-4363 IN denotes of
T8191 4364-4369 JJ denotes NF-κB
T8192 4370-4380 NN denotes activation
T8193 4381-4383 IN denotes in
T8194 4384-4396 JJ denotes inflammasome
T8195 4397-4407 NN denotes activation
T8196 4408-4411 CC denotes and
T8197 4412-4417 JJ denotes IL-1β
T8198 4418-4427 NN denotes secretion
T8199 4428-4430 VBZ denotes is
T8200 4431-4434 RB denotes not
T8201 4435-4450 JJ denotes straightforward
T8202 4450-4451 . denotes .
T8203 4452-4459 NNS denotes Studies
T8204 4460-4464 VBP denotes have
T8205 4465-4473 VBN denotes revealed
T8206 4474-4476 DT denotes an
T8207 4477-4486 JJ denotes essential
T8208 4487-4491 NN denotes role
T8209 4492-4495 IN denotes for
T8210 4496-4501 JJ denotes NF-κB
T8211 4502-4512 NN denotes activation
T8212 4513-4515 IN denotes in
T8213 4516-4519 DT denotes the
T8214 4520-4530 NN denotes production
T8215 4531-4533 IN denotes of
T8216 4534-4543 NN denotes pro-IL-1β
T8217 4544-4547 CC denotes and
T8218 4548-4560 JJ denotes inflammasome
T8219 4561-4571 NNS denotes components
T8220 4572-4576 JJ denotes such
T8221 4577-4579 IN denotes as
T8222 4580-4585 NNP denotes NLRP3
T8223 4586-4587 NNP denotes [
T8224 4587-4589 CD denotes 22
T8225 4589-4590 NNP denotes ]
T8226 4590-4591 , denotes ,
T8227 4592-4593 NNP denotes [
T8228 4593-4595 CD denotes 23
T8229 4595-4596 NNP denotes ]
T8230 4596-4597 . denotes .
T8231 4598-4600 IN denotes In
T8232 4601-4609 NN denotes contrast
T8233 4609-4610 , denotes ,
T8234 4611-4619 NN denotes deletion
T8235 4620-4622 IN denotes of
T8236 4623-4627 NNP denotes IKKβ
T8237 4627-4628 , denotes ,
T8238 4629-4630 DT denotes a
T8239 4631-4637 NN denotes kinase
T8240 4638-4647 JJ denotes essential
T8241 4648-4650 IN denotes in
T8242 4651-4656 JJ denotes NF-κB
T8243 4657-4667 NN denotes activation
T8244 4667-4668 , denotes ,
T8245 4669-4678 VBZ denotes increases
T8246 4679-4684 JJ denotes IL-1β
T8247 4685-4694 NN denotes secretion
T8248 4695-4697 IN denotes in
T8249 4698-4704 JJ denotes murine
T8250 4705-4716 NNS denotes macrophages
T8251 4717-4718 NNP denotes [
T8252 4718-4720 CD denotes 56
T8253 4720-4721 NNP denotes ]
T8254 4721-4722 , denotes ,
T8255 4723-4724 NNP denotes [
T8256 4724-4726 CD denotes 57
T8257 4726-4727 NNP denotes ]
T8258 4728-4731 CC denotes and
T8259 4732-4744 VBZ denotes demonstrates
T8260 4745-4746 DT denotes a
T8261 4747-4751 JJ denotes dual
T8262 4752-4756 NN denotes role
T8263 4757-4760 IN denotes for
T8264 4761-4766 NN denotes NF-κB
T8265 4767-4769 IN denotes in
T8266 4770-4780 NN denotes regulation
T8267 4781-4783 IN denotes of
T8268 4784-4789 NN denotes IL-1β
T8269 4789-4790 . denotes .
T8270 4791-4793 TO denotes To
T8271 4794-4801 VB denotes address
T8272 4802-4806 DT denotes this
T8273 4807-4818 NN denotes uncertainty
T8274 4819-4821 IN denotes in
T8275 4822-4825 PRP$ denotes our
T8276 4826-4837 NNS denotes experiments
T8277 4838-4840 PRP denotes we
T8278 4841-4845 RB denotes also
T8279 4846-4856 VBD denotes quantified
T8280 4857-4861 NNP denotes IL-8
T8281 4861-4862 , denotes ,
T8282 4863-4865 DT denotes an
T8283 4866-4875 JJ denotes important
T8284 4876-4878 NNP denotes CF
T8285 4879-4887 NN denotes cytokine
T8286 4888-4891 CC denotes and
T8287 4892-4898 NN denotes marker
T8288 4899-4901 IN denotes of
T8289 4902-4907 JJ denotes NF-κB
T8290 4908-4918 NN denotes activation
T8291 4919-4920 NNP denotes [
T8292 4920-4922 CD denotes 58
T8293 4922-4923 NNP denotes ]
T8294 4923-4924 , denotes ,
T8295 4925-4928 CC denotes and
T8296 4929-4934 VBD denotes found
T8297 4935-4937 DT denotes no
T8298 4938-4949 NNS denotes differences
T8299 4950-4957 IN denotes between
T8300 4958-4960 NNP denotes CF
T8301 4961-4964 CC denotes and
T8302 4965-4972 VB denotes control
T8303 4973-4981 NNS denotes subjects
T8304 4981-4982 . denotes .
T8305 4983-4992 RB denotes Similarly
T8306 4992-4993 , denotes ,
T8307 4994-5000 NNS denotes levels
T8308 5001-5003 IN denotes of
T8309 5004-5017 JJ denotes intracellular
T8310 5018-5027 NN denotes pro-IL-1β
T8311 5028-5030 IN denotes in
T8312 5031-5036 CD denotes THP-1
T8313 5037-5042 NNS denotes cells
T8314 5043-5047 VBD denotes were
T8315 5048-5057 JJ denotes dependent
T8316 5058-5060 IN denotes on
T8317 5061-5066 JJ denotes NF-κB
T8318 5067-5075 NN denotes activity
T8319 5076-5079 CC denotes and
T8320 5080-5083 VBD denotes did
T8321 5084-5087 RB denotes not
T8322 5088-5096 VB denotes increase
T8323 5097-5101 IN denotes with
T8324 5102-5112 JJ denotes CFTRinh172
T8325 5113-5122 NN denotes treatment
T8326 5122-5123 . denotes .
T8327 5124-5134 JJ denotes Subsequent
T8328 5135-5144 NN denotes treatment
T8329 5145-5147 IN denotes of
T8330 5148-5153 CD denotes THP-1
T8331 5154-5159 NNS denotes cells
T8332 5160-5163 CC denotes and
T8333 5164-5169 NNS denotes PBMCs
T8334 5170-5174 IN denotes with
T8335 5175-5178 DT denotes the
T8336 5179-5184 JJ denotes NF-κB
T8337 5185-5194 NN denotes inhibitor
T8338 5195-5205 NN denotes Bay11-7082
T8339 5206-5219 RB denotes significantly
T8340 5220-5229 VBD denotes inhibited
T8341 5230-5234 DT denotes both
T8342 5235-5240 JJ denotes IL-1β
T8343 5241-5244 CC denotes and
T8344 5245-5249 JJ denotes IL-8
T8345 5250-5259 NN denotes secretion
T8346 5260-5261 -LRB- denotes (
T8347 5261-5265 NNP denotes Fig.
T8348 5266-5268 CD denotes 6d
T8349 5269-5270 NN denotes h
T8350 5270-5271 -RRB- denotes )
T8351 5271-5272 . denotes .
T8352 5273-5282 RB denotes Therefore
T8353 5282-5283 , denotes ,
T8354 5284-5287 DT denotes the
T8355 5288-5293 NNP denotes IL-1β
T8356 5294-5297 CC denotes and
T8357 5298-5302 NNP denotes IL-8
T8358 5303-5312 NNS denotes responses
T8359 5313-5321 VBD denotes observed
T8360 5322-5326 VBD denotes were
T8361 5327-5331 DT denotes both
T8362 5332-5341 JJ denotes dependent
T8363 5342-5346 IN denotes upon
T8364 5347-5352 JJ denotes NF-κB
T8365 5353-5363 NN denotes activation
T8366 5363-5364 . denotes .
T8367 5365-5372 VBG denotes Priming
T8368 5373-5377 IN denotes with
T8369 5378-5389 JJ denotes heat-killed
T8370 5390-5392 NNP denotes P.
T8371 5393-5403 NN denotes aeruginosa
T8372 5403-5404 , denotes ,
T8373 5405-5409 IN denotes like
T8374 5410-5413 NNP denotes LPS
T8375 5413-5414 , denotes ,
T8376 5415-5417 VBZ denotes is
T8377 5418-5424 JJ denotes unable
T8378 5425-5427 TO denotes to
T8379 5428-5434 VB denotes induce
T8380 5435-5436 DT denotes a
T8381 5437-5443 JJ denotes strong
T8382 5444-5449 JJ denotes IL-1β
T8383 5450-5458 NN denotes response
T8384 5459-5461 IN denotes as
T8385 5462-5470 VBN denotes compared
T8386 5471-5473 TO denotes to
T8387 5474-5478 VB denotes live
T8388 5479-5481 NNP denotes P.
T8389 5482-5492 NN denotes aeruginosa
T8390 5493-5494 -LRB- denotes (
T8391 5494-5498 NNP denotes Fig.
T8392 5499-5501 CD denotes 6c
T8393 5501-5502 -RRB- denotes )
T8394 5502-5503 , denotes ,
T8395 5504-5507 CC denotes but
T8396 5508-5517 VBD denotes generated
T8397 5518-5525 JJR denotes greater
T8398 5526-5531 NNP denotes NF-κB
T8399 5531-5532 NNP denotes /
T8400 5532-5536 NNP denotes AP-1
T8401 5537-5547 NN denotes activation
T8402 5548-5549 -LRB- denotes (
T8403 5549-5553 NNP denotes Fig.
T8404 5554-5556 CD denotes 6a
T8405 5556-5557 -RRB- denotes )
T8406 5558-5561 CC denotes and
T8407 5562-5566 JJ denotes IL-8
T8408 5567-5576 NN denotes secretion
T8409 5577-5578 -LRB- denotes (
T8410 5578-5582 NNP denotes Fig.
T8411 5583-5585 CD denotes 6b
T8412 5585-5586 -RRB- denotes )
T8413 5587-5591 IN denotes than
T8414 5592-5596 JJ denotes live
T8415 5597-5605 NNS denotes bacteria
T8416 5606-5613 IN denotes despite
T8417 5614-5625 NN denotes stimulation
T8418 5626-5628 IN denotes at
T8419 5629-5639 JJ denotes equivalent
T8420 5640-5644 NNS denotes MOIs
T8421 5644-5645 . denotes .
T8422 5646-5650 DT denotes This
T8423 5651-5654 MD denotes may
T8424 5655-5657 VB denotes be
T8425 5658-5668 JJ denotes indicative
T8426 5669-5671 IN denotes of
T8427 5672-5675 DT denotes the
T8428 5676-5685 JJ denotes different
T8429 5686-5692 NN denotes degree
T8430 5693-5696 CC denotes and
T8431 5697-5704 NN denotes quality
T8432 5705-5707 IN denotes of
T8433 5708-5711 DT denotes the
T8434 5712-5724 JJ denotes inflammatory
T8435 5725-5733 NN denotes response
T8436 5734-5743 VBN denotes generated
T8437 5744-5746 IN denotes by
T8438 5747-5751 JJ denotes live
T8439 5752-5754 IN denotes as
T8440 5755-5762 VBN denotes opposed
T8441 5763-5765 TO denotes to
T8442 5766-5770 JJ denotes dead
T8443 5771-5779 NNS denotes bacteria
T8444 5780-5781 NNP denotes [
T8445 5781-5783 CD denotes 59
T8446 5783-5784 NNP denotes ]
T8447 5784-5785 . denotes .
T8448 5786-5795 JJ denotes Potential
T8449 5796-5808 NNS denotes shortcomings
T8450 5809-5811 IN denotes of
T8451 5812-5817 DT denotes these
T8452 5818-5829 NNS denotes experiments
T8453 5830-5837 VBP denotes include
T8454 5838-5841 PRP$ denotes its
T8455 5842-5857 NN denotes translatability
T8456 5858-5860 TO denotes to
T8457 5861-5865 NN denotes lung
T8458 5866-5873 NN denotes disease
T8459 5874-5877 CC denotes and
T8460 5878-5884 NNS denotes issues
T8461 5885-5892 VBN denotes related
T8462 5893-5895 TO denotes to
T8463 5896-5899 DT denotes the
T8464 5900-5915 NN denotes hypermutability
T8465 5916-5918 IN denotes of
T8466 5919-5921 NNP denotes P.
T8467 5922-5932 NN denotes aeruginosa
T8468 5933-5939 IN denotes during
T8469 5940-5943 DT denotes the
T8470 5944-5953 NN denotes evolution
T8471 5954-5956 IN denotes of
T8472 5957-5964 JJ denotes chronic
T8473 5965-5974 NN denotes infection
T8474 5974-5975 . denotes .
T8475 5976-5984 IN denotes Although
T8476 5985-5988 DT denotes the
T8477 5989-5998 NNS denotes responses
T8478 5999-6007 VBN denotes measured
T8479 6008-6010 IN denotes in
T8480 6011-6021 JJ denotes peripheral
T8481 6022-6027 NN denotes blood
T8482 6028-6033 NNS denotes cells
T8483 6034-6037 MD denotes may
T8484 6038-6041 RB denotes not
T8485 6042-6052 RB denotes completely
T8486 6053-6060 VB denotes reflect
T8487 6061-6064 DT denotes the
T8488 6065-6074 NNS denotes responses
T8489 6075-6084 VBG denotes occurring
T8490 6085-6087 IN denotes in
T8491 6088-6091 DT denotes the
T8492 6092-6094 NNP denotes CF
T8493 6095-6099 NN denotes lung
T8494 6099-6100 , denotes ,
T8495 6101-6106 NNS denotes PBMCs
T8496 6107-6111 VBP denotes have
T8497 6112-6113 DT denotes a
T8498 6114-6120 NN denotes number
T8499 6121-6123 IN denotes of
T8500 6124-6130 JJ denotes useful
T8501 6131-6141 NNS denotes advantages
T8502 6141-6142 : denotes :
T8503 6143-6144 -LRB- denotes (
T8504 6144-6145 FW denotes i
T8505 6145-6146 -RRB- denotes )
T8506 6147-6152 NNS denotes PBMCs
T8507 6153-6156 VBP denotes are
T8508 6157-6160 RB denotes not
T8509 6161-6168 JJ denotes subject
T8510 6169-6171 TO denotes to
T8511 6172-6183 NNS denotes alterations
T8512 6184-6188 WDT denotes that
T8513 6189-6192 MD denotes may
T8514 6193-6199 VB denotes emerge
T8515 6200-6204 IN denotes from
T8516 6205-6214 JJ denotes long-term
T8517 6215-6219 NN denotes cell
T8518 6220-6227 NN denotes culture
T8519 6227-6228 , denotes ,
T8520 6229-6236 VBG denotes cloning
T8521 6237-6240 CC denotes and
T8522 6241-6256 NN denotes immortalization
T8523 6256-6257 , denotes ,
T8524 6258-6261 CC denotes and
T8525 6262-6263 -LRB- denotes (
T8526 6263-6265 FW denotes ii
T8527 6265-6266 -RRB- denotes )
T8528 6267-6272 VBZ denotes PBMCs
T8529 6273-6280 VB denotes express
T8530 6281-6282 DT denotes a
T8531 6283-6288 JJ denotes large
T8532 6289-6299 NN denotes repertoire
T8533 6300-6302 IN denotes of
T8534 6303-6309 NN denotes innate
T8535 6310-6316 JJ denotes immune
T8536 6317-6326 NNS denotes receptors
T8537 6327-6330 CC denotes and
T8538 6331-6338 VB denotes secrete
T8539 6339-6340 DT denotes a
T8540 6341-6346 JJ denotes broad
T8541 6347-6352 NN denotes array
T8542 6353-6355 IN denotes of
T8543 6356-6365 NNS denotes cytokines
T8544 6366-6369 CC denotes and
T8545 6370-6380 NNS denotes chemokines
T8546 6381-6389 VBG denotes allowing
T8547 6390-6403 JJ denotes comprehensive
T8548 6404-6412 NN denotes analysis
T8549 6413-6415 IN denotes of
T8550 6416-6419 DT denotes the
T8551 6420-6430 NN denotes modulation
T8552 6431-6433 IN denotes of
T8553 6434-6446 JJ denotes inflammatory
T8554 6447-6456 NNS denotes responses
T8555 6457-6459 IN denotes by
T8556 6460-6464 NNP denotes CFTR
T8557 6464-6465 . denotes .
T8558 6466-6479 NN denotes Consideration
T8559 6480-6484 MD denotes must
T8560 6485-6489 RB denotes also
T8561 6490-6492 VB denotes be
T8562 6493-6498 VBN denotes given
T8563 6499-6501 TO denotes to
T8564 6502-6505 DT denotes the
T8565 6506-6512 NN denotes nature
T8566 6513-6515 IN denotes of
T8567 6516-6518 NNP denotes P.
T8568 6519-6529 NN denotes aeruginosa
T8569 6530-6539 NN denotes infection
T8570 6540-6543 CC denotes and
T8571 6544-6553 JJ denotes genotypic
T8572 6554-6561 NNS denotes changes
T8573 6562-6564 IN denotes in
T8574 6565-6567 NNP denotes P.
T8575 6568-6578 NN denotes aeruginosa
T8576 6579-6581 IN denotes as
T8577 6582-6591 NN denotes infection
T8578 6592-6602 VBZ denotes progresses
T8579 6602-6603 . denotes .
T8580 6604-6606 NNP denotes P.
T8581 6607-6617 NN denotes aeruginosa
T8582 6618-6626 VBZ denotes mediates
T8583 6627-6639 JJ denotes inflammasome
T8584 6640-6650 NN denotes activation
T8585 6651-6658 IN denotes through
T8586 6659-6662 PRP$ denotes its
T8587 6663-6667 NN denotes type
T8588 6668-6671 NNP denotes III
T8589 6672-6681 NN denotes secretion
T8590 6682-6688 NN denotes system
T8591 6689-6690 -LRB- denotes (
T8592 6690-6694 CD denotes T3SS
T8593 6694-6695 -RRB- denotes )
T8594 6696-6699 CC denotes and
T8595 6700-6703 DT denotes the
T8596 6704-6709 NNP denotes NLRC4
T8597 6710-6722 JJ denotes inflammasome
T8598 6723-6724 NNP denotes [
T8599 6724-6726 CD denotes 19
T8600 6726-6727 NNP denotes ]
T8601 6727-6728 , denotes ,
T8602 6729-6730 NNP denotes [
T8603 6730-6732 CD denotes 20
T8604 6732-6733 NNP denotes ]
T8605 6733-6734 . denotes .
T8606 6735-6742 RB denotes However
T8607 6742-6743 , denotes ,
T8608 6744-6750 NNS denotes clones
T8609 6751-6753 IN denotes of
T8610 6754-6756 NNP denotes P.
T8611 6757-6767 NN denotes aeruginosa
T8612 6768-6779 VBN denotes established
T8613 6780-6786 IN denotes during
T8614 6787-6794 JJ denotes chronic
T8615 6795-6804 NN denotes infection
T8616 6805-6808 MD denotes may
T8617 6809-6819 VB denotes accumulate
T8618 6820-6829 NNS denotes mutations
T8619 6830-6832 IN denotes in
T8620 6833-6842 NN denotes virulence
T8621 6843-6850 NNS denotes factors
T8622 6851-6855 JJ denotes such
T8623 6856-6858 IN denotes as
T8624 6859-6863 NNP denotes exsA
T8625 6864-6865 NNP denotes [
T8626 6865-6867 CD denotes 60
T8627 6867-6868 NNP denotes ]
T8628 6868-6869 . denotes .
T8629 6870-6872 IN denotes By
T8630 6873-6882 VBG denotes employing
T8631 6883-6884 DT denotes a
T8632 6885-6893 NN denotes deletion
T8633 6894-6900 JJ denotes mutant
T8634 6901-6903 IN denotes in
T8635 6904-6908 NNP denotes exsA
T8636 6908-6909 , denotes ,
T8637 6910-6913 DT denotes the
T8638 6914-6917 JJ denotes key
T8639 6918-6927 NN denotes regulator
T8640 6928-6930 IN denotes in
T8641 6931-6935 CD denotes T3SS
T8642 6936-6949 NN denotes transcription
T8643 6949-6950 , denotes ,
T8644 6951-6953 PRP denotes we
T8645 6954-6963 VBD denotes confirmed
T8646 6964-6968 IN denotes that
T8647 6969-6972 DT denotes the
T8648 6973-6977 CD denotes T3SS
T8649 6978-6980 VBZ denotes is
T8650 6981-6990 JJ denotes important
T8651 6991-6994 IN denotes for
T8652 6995-7000 JJ denotes IL-1β
T8653 7001-7010 NN denotes secretion
T8654 7011-7012 -LRB- denotes (
T8655 7012-7016 NNP denotes Fig.
T8656 7017-7019 CD denotes 5a
T8657 7020-7021 NN denotes b
T8658 7021-7022 -RRB- denotes )
T8659 7022-7023 , denotes ,
T8660 7024-7027 CC denotes and
T8661 7028-7032 IN denotes that
T8662 7033-7042 VBG denotes depending
T8663 7043-7045 IN denotes on
T8664 7046-7049 DT denotes the
T8665 7050-7060 NN denotes adaptation
T8666 7061-7063 IN denotes in
T8667 7064-7068 NN denotes type
T8668 7069-7072 NNP denotes III
T8669 7073-7082 NN denotes secretion
T8670 7082-7083 , denotes ,
T8671 7084-7087 DT denotes the
T8672 7088-7092 NN denotes host
T8673 7093-7098 NN denotes IL-1β
T8674 7099-7107 NN denotes response
T8675 7108-7111 MD denotes may
T8676 7112-7114 VB denotes be
T8677 7115-7117 RB denotes up
T8678 7118-7120 CC denotes or
T8679 7121-7134 VBN denotes downregulated
T8680 7135-7136 NNP denotes [
T8681 7136-7138 CD denotes 19
T8682 7138-7139 NNP denotes ]
T8683 7139-7140 , denotes ,
T8684 7141-7142 NNP denotes [
T8685 7142-7144 CD denotes 60
T8686 7144-7145 NNP denotes ]
T8687 7145-7146 , denotes ,
T8688 7147-7148 NNP denotes [
T8689 7148-7150 CD denotes 61
T8690 7150-7151 NNP denotes ]
T8691 7151-7152 . denotes .
T8692 7153-7155 IN denotes In
T8693 7156-7166 NN denotes conclusion
T8694 7166-7167 , denotes ,
T8695 7168-7171 PRP$ denotes our
T8696 7172-7176 NNS denotes data
T8697 7177-7180 VBP denotes are
T8698 7181-7191 JJ denotes consistent
T8699 7192-7196 IN denotes with
T8700 7197-7198 DT denotes a
T8701 7199-7203 NN denotes role
T8702 7204-7207 IN denotes for
T8703 7208-7221 JJ denotes hematopoietic
T8704 7222-7227 NNS denotes cells
T8705 7227-7228 , denotes ,
T8706 7229-7232 RB denotes not
T8707 7233-7239 VB denotes airway
T8708 7240-7250 JJ denotes epithelial
T8709 7251-7256 NNS denotes cells
T8710 7256-7257 , denotes ,
T8711 7258-7260 IN denotes as
T8712 7261-7264 DT denotes the
T8713 7265-7270 JJ denotes major
T8714 7271-7277 NN denotes source
T8715 7278-7280 IN denotes of
T8716 7281-7302 JJ denotes inflammasome-mediated
T8717 7303-7308 JJ denotes IL-1β
T8718 7309-7319 NN denotes production
T8719 7320-7322 IN denotes in
T8720 7323-7326 DT denotes the
T8721 7327-7332 NNS denotes lungs
T8722 7333-7335 IN denotes in
T8723 7336-7344 NN denotes response
T8724 7345-7347 TO denotes to
T8725 7348-7351 NNP denotes ATP
T8726 7352-7355 CC denotes and
T8727 7356-7358 NNP denotes P.
T8728 7359-7369 NN denotes aeruginosa
T8729 7369-7370 . denotes .
T8730 7371-7382 RB denotes Furthermore
T8731 7382-7383 , denotes ,
T8732 7384-7386 PRP denotes we
T8733 7387-7391 VBP denotes find
T8734 7392-7398 JJ denotes little
T8735 7399-7407 NN denotes evidence
T8736 7408-7410 TO denotes to
T8737 7411-7418 VB denotes support
T8738 7419-7421 DT denotes an
T8739 7422-7431 VBN denotes increased
T8740 7432-7437 NN denotes IL-1β
T8741 7438-7450 JJ denotes inflammatory
T8742 7451-7459 NN denotes response
T8743 7460-7462 TO denotes to
T8744 7463-7468 NNP denotes NF-κB
T8745 7468-7469 NNP denotes /
T8746 7469-7481 NNP denotes Inflammasome
T8747 7482-7493 NN denotes stimulation
T8748 7494-7496 IN denotes in
T8749 7497-7499 NNP denotes CF
T8750 7500-7508 NNS denotes patients
T8751 7508-7509 . denotes .
T8752 7510-7517 JJ denotes Further
T8753 7518-7525 NNS denotes studies
T8754 7526-7529 VBP denotes are
T8755 7530-7539 VBN denotes warranted
T8756 7540-7542 TO denotes to
T8757 7543-7552 VB denotes determine
T8758 7553-7555 IN denotes if
T8759 7556-7567 NNS denotes adaptations
T8760 7568-7570 IN denotes of
T8761 7571-7573 NNP denotes P.
T8762 7574-7584 NN denotes aeruginosa
T8763 7585-7591 IN denotes during
T8764 7592-7595 DT denotes the
T8765 7596-7602 NN denotes course
T8766 7603-7605 IN denotes of
T8767 7606-7613 JJ denotes chronic
T8768 7614-7618 NN denotes lung
T8769 7619-7628 NN denotes infection
T8770 7629-7635 NNS denotes alters
T8771 7636-7648 JJ denotes inflammasome
T8772 7649-7659 NN denotes activation
T8773 7659-7660 , denotes ,
T8774 7661-7664 CC denotes and
T8775 7665-7672 IN denotes whether
T8776 7673-7677 DT denotes this
T8777 7678-7681 MD denotes can
T8778 7682-7684 VB denotes be
T8779 7685-7695 VBN denotes correlated
T8780 7696-7700 IN denotes with
T8781 7701-7708 NN denotes disease
T8782 7709-7717 NN denotes severity
T8783 7718-7720 IN denotes in
T8784 7721-7724 NNP denotes CF.
R6520 T7430 T7434 nsubjpass Levels,increased
R6521 T7431 T7430 prep of,Levels
R6522 T7432 T7431 pobj IL-1β,of
R6523 T7433 T7434 auxpass are,increased
R6524 T7434 T7434 ROOT increased,increased
R6525 T7435 T7434 prep in,increased
R6526 T7436 T7437 det the,BALF
R6527 T7437 T7435 pobj BALF,in
R6528 T7438 T7437 prep of,BALF
R6529 T7439 T7440 compound CF,patients
R6530 T7440 T7438 pobj patients,of
R6531 T7441 T7434 cc but,increased
R6532 T7442 T7444 det the,source
R6533 T7443 T7444 amod cellular,source
R6534 T7444 T7458 nsubj source,are
R6535 T7445 T7444 prep of,source
R6536 T7446 T7447 det this,cytokine
R6537 T7447 T7445 pobj cytokine,of
R6538 T7448 T7447 cc and,cytokine
R6539 T7449 T7450 poss its,production
R6540 T7450 T7444 conj production,source
R6541 T7451 T7450 prep in,production
R6542 T7452 T7453 det the,context
R6543 T7453 T7451 pobj context,in
R6544 T7454 T7453 prep of,context
R6545 T7455 T7457 amod targeted,activation
R6546 T7456 T7457 amod inflammasome,activation
R6547 T7457 T7454 pobj activation,of
R6548 T7458 T7434 conj are,increased
R6549 T7459 T7458 advmod still,are
R6550 T7460 T7458 acomp unclear,are
R6551 T7461 T7458 punct .,are
R6552 T7462 T7464 nsubj We,studied
R6553 T7463 T7464 advmod first,studied
R6554 T7464 T7464 ROOT studied,studied
R6555 T7465 T7467 nmod airway,cells
R6556 T7466 T7467 amod epithelial,cells
R6557 T7467 T7464 dobj cells,studied
R6558 T7468 T7467 amod due,cells
R6559 T7469 T7468 pcomp to,due
R6560 T7470 T7471 poss their,role
R6561 T7471 T7468 pobj role,due
R6562 T7472 T7471 prep in,role
R6563 T7473 T7474 compound barrier,function
R6564 T7474 T7472 pobj function,in
R6565 T7475 T7471 punct ",",role
R6566 T7476 T7471 conj proximity,role
R6567 T7477 T7476 prep to,proximity
R6568 T7478 T7477 pobj infection,to
R6569 T7479 T7476 punct ",",proximity
R6570 T7480 T7476 cc and,proximity
R6571 T7481 T7476 conj ability,proximity
R6572 T7482 T7483 aux to,produce
R6573 T7483 T7481 acl produce,ability
R6574 T7484 T7485 amod high,levels
R6575 T7485 T7483 dobj levels,produce
R6576 T7486 T7485 prep of,levels
R6577 T7487 T7488 amod pro-inflammatory,cytokines
R6578 T7488 T7486 pobj cytokines,of
R6579 T7489 T7464 punct .,studied
R6580 T7490 T7493 advmod However,found
R6581 T7491 T7493 punct ",",found
R6582 T7492 T7493 nsubj we,found
R6583 T7493 T7493 ROOT found,found
R6584 T7494 T7500 mark that,produce
R6585 T7495 T7497 amod bronchial,cells
R6586 T7496 T7497 amod epithelial,cells
R6587 T7497 T7500 nsubj cells,produce
R6588 T7498 T7500 aux do,produce
R6589 T7562 T7550 cc as,in
R6590 T7499 T7500 neg not,produce
R6591 T7563 T7550 conj in,in
R6592 T7500 T7493 ccomp produce,found
R6593 T7564 T7563 pobj PBMCs,in
R6594 T7565 T7549 prep at,expressed
R6595 T7501 T7502 amod significant,amounts
R6596 T7566 T7568 preconj both,mRNA
R6597 T7567 T7568 det the,mRNA
R6598 T7502 T7500 dobj amounts,produce
R6599 T7568 T7565 pobj mRNA,at
R6600 T7569 T7568 cc and,mRNA
R6601 T7570 T7571 compound protein,level
R6602 T7503 T7502 prep of,amounts
R6603 T7571 T7572 compound level,[
R6604 T7572 T7568 conj [,mRNA
R6605 T7573 T7574 nummod 40,]
R6606 T7504 T7503 pobj IL-1β,of
R6607 T7574 T7568 conj ],mRNA
R6608 T7575 T7574 punct ",",]
R6609 T7576 T7574 conj [,]
R6610 T7505 T7500 cc and,produce
R6611 T7506 T7508 aux do,show
R6612 T7577 T7578 nummod 41,]
R6613 T7507 T7508 neg not,show
R6614 T7578 T7574 conj ],]
R6615 T7579 T7578 punct ",",]
R6616 T7508 T7500 conj show,produce
R6617 T7580 T7578 cc and,]
R6618 T7581 T7582 poss its,loss
R6619 T7582 T7578 conj loss,]
R6620 T7583 T7585 auxpass is,associated
R6621 T7584 T7585 advmod frequently,associated
R6622 T7585 T7549 conj associated,expressed
R6623 T7586 T7585 prep with,associated
R6624 T7509 T7511 det a,increase
R6625 T7587 T7590 det an,phenotype
R6626 T7588 T7590 amod augmented,phenotype
R6627 T7589 T7590 amod inflammatory,phenotype
R6628 T7590 T7586 pobj phenotype,with
R6629 T7510 T7511 amod significant,increase
R6630 T7591 T7549 punct .,expressed
R6631 T7592 T7624 prep Despite,shown
R6632 T7593 T7594 poss our,findings
R6633 T7594 T7592 pobj findings,Despite
R6634 T7595 T7594 acl indicating,findings
R6635 T7511 T7508 dobj increase,show
R6636 T7596 T7604 mark that,are
R6637 T7597 T7599 amod bronchial,cells
R6638 T7598 T7599 amod epithelial,cells
R6639 T7599 T7604 nsubj cells,are
R6640 T7512 T7511 prep in,increase
R6641 T7600 T7601 advmod when,grown
R6642 T7601 T7599 advcl grown,cells
R6643 T7602 T7601 prep in,grown
R6644 T7513 T7514 amod caspase-1,activation
R6645 T7603 T7602 pobj vitro,in
R6646 T7514 T7512 pobj activation,in
R6647 T7604 T7595 ccomp are,indicating
R6648 T7605 T7604 acomp unlikely,are
R6649 T7515 T7511 prep in,increase
R6650 T7606 T7609 aux to,involved
R6651 T7607 T7609 auxpass be,involved
R6652 T7608 T7609 advmod significantly,involved
R6653 T7516 T7515 pobj response,in
R6654 T7609 T7605 xcomp involved,unlikely
R6655 T7610 T7609 prep in,involved
R6656 T7611 T7613 det the,production
R6657 T7517 T7516 prep to,response
R6658 T7612 T7613 amod direct,production
R6659 T7613 T7610 pobj production,in
R6660 T7518 T7517 pobj PAO1,to
R6661 T7614 T7613 prep of,production
R6662 T7519 T7518 cc and,PAO1
R6663 T7520 T7518 conj LPS+ATP,PAO1
R6664 T7615 T7614 pobj IL-1β,of
R6665 T7521 T7511 punct ",",increase
R6666 T7616 T7615 punct (,IL-1β
R6667 T7522 T7508 prep in,show
R6668 T7617 T7615 appos Fig.,IL-1β
R6669 T7523 T7522 pobj comparison,in
R6670 T7618 T7617 nummod 2a,Fig.
R6671 T7619 T7615 appos d,IL-1β
R6672 T7620 T7615 punct ),IL-1β
R6673 T7621 T7624 punct ",",shown
R6674 T7622 T7624 nsubj others,shown
R6675 T7623 T7624 aux have,shown
R6676 T7624 T7624 ROOT shown,shown
R6677 T7625 T7626 poss their,capacity
R6678 T7626 T7624 dobj capacity,shown
R6679 T7524 T7523 prep to,comparison
R6680 T7627 T7628 aux to,respond
R6681 T7628 T7626 acl respond,capacity
R6682 T7629 T7628 prep to,respond
R6683 T7525 T7527 amod hematopoeitic,cells
R6684 T7630 T7632 advmod alveolar,IL-1β
R6685 T7631 T7632 amod macrophage-derived,IL-1β
R6686 T7632 T7629 pobj IL-1β,to
R6687 T7633 T7628 cc and,respond
R6688 T7526 T7527 amod mononuclear,cells
R6689 T7634 T7635 aux to,amplify
R6690 T7635 T7628 conj amplify,respond
R6691 T7636 T7638 det the,response
R6692 T7527 T7524 pobj cells,to
R6693 T7637 T7638 amod inflammatory,response
R6694 T7638 T7635 dobj response,amplify
R6695 T7639 T7635 prep through,amplify
R6696 T7528 T7493 punct .,found
R6697 T7640 T7641 det the,induction
R6698 T7641 T7639 pobj induction,through
R6699 T7529 T7530 amod Hematopoeitically-derived,cells
R6700 T7642 T7641 prep of,induction
R6701 T7643 T7642 pobj chemokines,of
R6702 T7644 T7643 cc and,chemokines
R6703 T7530 T7538 nsubj cells,appear
R6704 T7645 T7643 conj recruitment,chemokines
R6705 T7646 T7645 prep of,recruitment
R6706 T7647 T7649 amod inflammatory,cells
R6707 T7531 T7530 punct ",",cells
R6708 T7648 T7649 compound effector,cells
R6709 T7649 T7646 pobj cells,of
R6710 T7650 T7652 nmod [,]
R6711 T7532 T7533 amod such,as
R6712 T7651 T7652 nummod 42,]
R6713 T7652 T7641 appos ],induction
R6714 T7653 T7624 punct .,shown
R6715 T7654 T7655 det This,interaction
R6716 T7533 T7530 prep as,cells
R6717 T7655 T7657 nsubj interaction,constitute
R6718 T7656 T7657 aux may,constitute
R6719 T7534 T7533 pobj monocytes,as
R6720 T7657 T7657 ROOT constitute,constitute
R6721 T7658 T7660 det a,component
R6722 T7535 T7534 cc and,monocytes
R6723 T7536 T7534 conj macrophages,monocytes
R6724 T7537 T7530 punct ",",cells
R6725 T7659 T7660 amod critical,component
R6726 T7660 T7657 dobj component,constitute
R6727 T7661 T7662 aux to,effective
R6728 T7538 T7538 ROOT appear,appear
R6729 T7662 T7660 acl effective,component
R6730 T7663 T7664 compound host,defense
R6731 T7664 T7662 dobj defense,effective
R6732 T7539 T7540 aux to,be
R6733 T7665 T7662 cc and,effective
R6734 T7666 T7662 conj diminishing,effective
R6735 T7667 T7668 det the,capacity
R6736 T7540 T7538 xcomp be,appear
R6737 T7668 T7666 dobj capacity,diminishing
R6738 T7669 T7668 prep of,capacity
R6739 T7541 T7543 det a,source
R6740 T7670 T7671 compound host,cells
R6741 T7671 T7669 pobj cells,of
R6742 T7672 T7673 aux to,respond
R6743 T7673 T7657 advcl respond,constitute
R6744 T7542 T7543 amod principal,source
R6745 T7674 T7673 prep to,respond
R6746 T7675 T7674 pobj IL-1β,to
R6747 T7676 T7677 aux may,leave
R6748 T7543 T7540 attr source,be
R6749 T7677 T7657 conj leave,constitute
R6750 T7678 T7679 det the,host
R6751 T7679 T7677 dobj host,leave
R6752 T7544 T7543 prep of,source
R6753 T7680 T7677 oprd susceptible,leave
R6754 T7681 T7680 prep to,susceptible
R6755 T7682 T7681 pobj infections,to
R6756 T7545 T7544 pobj IL-1β,of
R6757 T7683 T7677 prep by,leave
R6758 T7684 T7683 pobj pathogens,by
R6759 T7685 T7686 amod such,as
R6760 T7546 T7538 punct .,appear
R6761 T7686 T7684 prep as,pathogens
R6762 T7687 T7688 compound P.,aeruginosa
R6763 T7547 T7549 nsubjpass CFTR,expressed
R6764 T7548 T7549 auxpass is,expressed
R6765 T7688 T7689 compound aeruginosa,[
R6766 T7689 T7686 pobj [,as
R6767 T7690 T7691 nummod 43,]
R6768 T7549 T7549 ROOT expressed,expressed
R6769 T7691 T7689 appos ],[
R6770 T7692 T7657 punct .,constitute
R6771 T7550 T7549 prep in,expressed
R6772 T7693 T7700 advmod Conversely,play
R6773 T7694 T7700 punct ",",play
R6774 T7695 T7700 nsubj overproduction,play
R6775 T7551 T7552 amod alveolar,macrophages
R6776 T7696 T7695 prep of,overproduction
R6777 T7697 T7696 pobj IL-1β,of
R6778 T7698 T7700 aux can,play
R6779 T7552 T7553 compound macrophages,[
R6780 T7699 T7700 advmod also,play
R6781 T7700 T7700 ROOT play,play
R6782 T7701 T7703 det a,role
R6783 T7702 T7703 amod key,role
R6784 T7553 T7555 nmod [,]
R6785 T7703 T7700 dobj role,play
R6786 T7704 T7700 prep in,play
R6787 T7554 T7555 nummod 32,]
R6788 T7705 T7707 amod chronic,responses
R6789 T7706 T7707 amod inflammatory,responses
R6790 T7555 T7550 pobj ],in
R6791 T7707 T7704 pobj responses,in
R6792 T7708 T7707 cc and,responses
R6793 T7709 T7710 compound cause,damage
R6794 T7710 T7707 conj damage,responses
R6795 T7556 T7555 punct ",",]
R6796 T7711 T7710 prep to,damage
R6797 T7712 T7714 det the,parenchyma
R6798 T7713 T7714 compound lung,parenchyma
R6799 T7714 T7711 pobj parenchyma,to
R6800 T7557 T7559 compound [,]
R6801 T7715 T7717 nmod [,]
R6802 T7716 T7717 nummod 44,]
R6803 T7717 T7714 appos ],parenchyma
R6804 T7558 T7559 compound 39,]
R6805 T7718 T7717 punct ",",]
R6806 T7719 T7721 nmod [,]
R6807 T7720 T7721 nummod 45,]
R6808 T7559 T7555 appos ],]
R6809 T7721 T7717 appos ],]
R6810 T7722 T7700 punct .,play
R6811 T7723 T7725 mark Although,hypothesized
R6812 T7560 T7562 advmod as,as
R6813 T7724 T7725 nsubj we,hypothesized
R6814 T7725 T7737 advcl hypothesized,found
R6815 T7726 T7730 mark that,secrete
R6816 T7561 T7562 advmod well,as
R6817 T7727 T7728 compound CF,cells
R6818 T7728 T7730 nsubj cells,secrete
R6819 T7729 T7730 aux would,secrete
R6820 T7756 T7755 nummod 5a,Fig.
R6821 T7730 T7725 ccomp secrete,hypothesized
R6822 T7731 T7732 amod increased,amounts
R6823 T7732 T7730 dobj amounts,secrete
R6824 T7733 T7732 prep of,amounts
R6825 T7734 T7733 pobj IL-1β,of
R6826 T7735 T7737 punct ",",found
R6827 T7736 T7737 nsubj we,found
R6828 T7757 T7753 appos b,controls
R6829 T7737 T7737 ROOT found,found
R6830 T7738 T7746 mark that,increased
R6831 T7739 T7740 amod IL-1β,production
R6832 T7758 T7746 punct ),increased
R6833 T7740 T7746 nsubjpass production,increased
R6834 T7741 T7740 prep in,production
R6835 T7742 T7743 compound CF,PBMCs
R6836 T7759 T7737 punct .,found
R6837 T7743 T7741 pobj PBMCs,in
R6838 T7760 T7761 nsubj This,was
R6839 T7744 T7746 auxpass was,increased
R6840 T7761 T7761 ROOT was,was
R6841 T7745 T7746 neg not,increased
R6842 T7746 T7737 ccomp increased,found
R6843 T7762 T7761 prep in,was
R6844 T7747 T7746 prep upon,increased
R6845 T7748 T7749 amod inflammasome,stimulation
R6846 T7749 T7747 pobj stimulation,upon
R6847 T7750 T7751 mark as,compared
R6848 T7751 T7746 advcl compared,increased
R6849 T7763 T7762 pobj contrast,in
R6850 T7752 T7751 prep to,compared
R6851 T7753 T7752 pobj controls,to
R6852 T7754 T7753 punct (,controls
R6853 T7764 T7763 prep to,contrast
R6854 T7755 T7753 appos Fig.,controls
R6855 T7765 T7767 det a,study
R6856 T7766 T7767 amod previous,study
R6857 T7767 T7764 pobj study,to
R6858 T7768 T7767 prep from,study
R6859 T7769 T7770 poss our,group
R6860 T7770 T7768 pobj group,from
R6861 T7822 T7824 mark if,were
R6862 T7771 T7770 punct ",",group
R6863 T7823 T7824 expl there,were
R6864 T7824 T7821 advcl were,anticipated
R6865 T7825 T7826 amod basal,levels
R6866 T7772 T7773 nsubj which,showed
R6867 T7826 T7824 attr levels,were
R6868 T7827 T7826 prep of,levels
R6869 T7828 T7829 amod NF-κB,activation
R6870 T7829 T7827 pobj activation,of
R6871 T7773 T7770 relcl showed,group
R6872 T7830 T7810 punct .,increased
R6873 T7831 T7832 nsubj Cells,deficient
R6874 T7832 T7832 ROOT deficient,deficient
R6875 T7833 T7832 prep in,deficient
R6876 T7834 T7833 pobj CFTR,in
R6877 T7835 T7836 auxpass are,thought
R6878 T7774 T7776 amod increased,production
R6879 T7836 T7832 conj thought,deficient
R6880 T7837 T7838 aux to,exhibit
R6881 T7838 T7836 xcomp exhibit,thought
R6882 T7775 T7776 amod IL-1β,production
R6883 T7839 T7842 det an,level
R6884 T7840 T7842 amod increased,level
R6885 T7841 T7842 amod basal,level
R6886 T7776 T7773 dobj production,showed
R6887 T7842 T7838 dobj level,exhibit
R6888 T7843 T7842 prep of,level
R6889 T7844 T7845 amod NF-κB,activity
R6890 T7777 T7776 prep by,production
R6891 T7845 T7843 pobj activity,of
R6892 T7846 T7845 punct ",",activity
R6893 T7847 T7848 nsubj which,leads
R6894 T7778 T7779 compound CF,PBMCs
R6895 T7779 T7777 pobj PBMCs,by
R6896 T7780 T7773 prep in,showed
R6897 T7848 T7842 relcl leads,level
R6898 T7781 T7780 pobj response,in
R6899 T7849 T7848 prep to,leads
R6900 T7850 T7853 amod increased,production
R6901 T7851 T7853 amod pro-inflammatory,production
R6902 T7782 T7781 prep to,response
R6903 T7852 T7853 compound cytokine,production
R6904 T7783 T7782 pobj LPS,to
R6905 T7784 T7786 nmod [,]
R6906 T7785 T7786 nummod 46,]
R6907 T7853 T7849 pobj production,to
R6908 T7854 T7853 prep including,production
R6909 T7786 T7783 appos ],LPS
R6910 T7855 T7857 det an,availability
R6911 T7856 T7857 amod increased,availability
R6912 T7857 T7854 pobj availability,including
R6913 T7787 T7761 punct ",",was
R6914 T7858 T7857 prep of,availability
R6915 T7788 T7793 mark although,accounted
R6916 T7789 T7790 det this,difference
R6917 T7859 T7858 pobj pro-IL-1β,of
R6918 T7860 T7857 prep for,availability
R6919 T7790 T7793 nsubjpass difference,accounted
R6920 T7861 T7860 pobj cleavage,for
R6921 T7862 T7861 cc and,cleavage
R6922 T7863 T7861 conj secretion,cleavage
R6923 T7864 T7832 punct .,deficient
R6924 T7865 T7866 det This,amplification
R6925 T7866 T7871 nsubjpass amplification,shown
R6926 T7867 T7866 prep of,amplification
R6927 T7791 T7793 aux may,accounted
R6928 T7868 T7869 amod IL-1β,secretion
R6929 T7869 T7867 pobj secretion,of
R6930 T7870 T7871 auxpass was,shown
R6931 T7792 T7793 auxpass be,accounted
R6932 T7871 T7871 ROOT shown,shown
R6933 T7872 T7871 agent by,shown
R6934 T7793 T7761 advcl accounted,was
R6935 T7873 T7872 pcomp priming,by
R6936 T7874 T7875 nummod THP-1,monocytes
R6937 T7875 T7873 dobj monocytes,priming
R6938 T7876 T7875 cc and,monocytes
R6939 T7794 T7793 prep for,accounted
R6940 T7877 T7875 conj PBMCs,monocytes
R6941 T7878 T7873 prep with,priming
R6942 T7795 T7793 agent by,accounted
R6943 T7879 T7881 amod heat-killed,aeruginosa
R6944 T7880 T7881 compound P.,aeruginosa
R6945 T7881 T7878 pobj aeruginosa,with
R6946 T7796 T7797 amod technical,issues
R6947 T7882 T7881 cc or,aeruginosa
R6948 T7883 T7881 conj LPS,aeruginosa
R6949 T7884 T7873 advmod prior,priming
R6950 T7885 T7884 prep to,prior
R6951 T7797 T7795 pobj issues,by
R6952 T7886 T7885 pobj stimulation,to
R6953 T7887 T7873 prep with,priming
R6954 T7798 T7793 prep in,accounted
R6955 T7888 T7890 amod live,aeruginosa
R6956 T7889 T7890 compound P.,aeruginosa
R6957 T7890 T7887 pobj aeruginosa,with
R6958 T7799 T7800 compound stimulation,time
R6959 T7891 T7871 punct .,shown
R6960 T7892 T7896 det This,secretion
R6961 T7893 T7894 advmod dramatically,increased
R6962 T7800 T7798 pobj time,in
R6963 T7894 T7896 amod increased,secretion
R6964 T7895 T7896 amod IL-1β,secretion
R6965 T7896 T7896 ROOT secretion,secretion
R6966 T7801 T7800 cc and,time
R6967 T7897 T7896 prep over,secretion
R6968 T7898 T7897 pobj stimulation,over
R6969 T7899 T7896 prep with,secretion
R6970 T7900 T7902 amod live,aeruginosa
R6971 T7802 T7800 conj dose,time
R6972 T7901 T7902 compound P.,aeruginosa
R6973 T7902 T7899 pobj aeruginosa,with
R6974 T7903 T7896 prep without,secretion
R6975 T7904 T7903 pcomp priming,without
R6976 T7905 T7906 punct (,Fig.
R6977 T7906 T7896 appos Fig.,secretion
R6978 T7803 T7761 punct .,was
R6979 T7907 T7906 nummod 6c,Fig.
R6980 T7908 T7906 punct ),Fig.
R6981 T7909 T7896 punct .,secretion
R6982 T7804 T7810 advmod Moreover,increased
R6983 T7910 T7923 advmod Similarly,be
R6984 T7911 T7923 punct ",",be
R6985 T7912 T7915 mark if,expressed
R6986 T7805 T7810 punct ",",increased
R6987 T7913 T7914 compound CF,PBMCs
R6988 T7914 T7915 nsubj PBMCs,expressed
R6989 T7915 T7923 advcl expressed,be
R6990 T7806 T7807 amod IL-1β,production
R6991 T7916 T7919 amod increased,activity
R6992 T7917 T7919 amod basal,activity
R6993 T7918 T7919 compound NF-κB,activity
R6994 T7807 T7810 nsubjpass production,increased
R6995 T7919 T7915 dobj activity,expressed
R6996 T7920 T7923 punct ",",be
R6997 T7921 T7923 expl there,be
R6998 T7922 T7923 aux would,be
R6999 T7808 T7810 auxpass was,increased
R7000 T7923 T7923 ROOT be,be
R7001 T7924 T7925 det an,increase
R7002 T7925 T7923 attr increase,be
R7003 T7809 T7810 neg not,increased
R7004 T7926 T7925 prep in,increase
R7005 T7927 T7928 amod IL-1β,secretion
R7006 T7810 T7810 ROOT increased,increased
R7007 T7928 T7926 pobj secretion,in
R7008 T7929 T7925 prep in,increase
R7009 T7930 T7931 det the,absence
R7010 T7811 T7810 prep in,increased
R7011 T7931 T7929 pobj absence,in
R7012 T7812 T7813 compound CF,PBMCs
R7013 T7932 T7931 prep of,absence
R7014 T7933 T7934 compound LPS,priming
R7015 T7934 T7932 pobj priming,of
R7016 T7813 T7811 pobj PBMCs,in
R7017 T7935 T7923 punct .,be
R7018 T7936 T7943 advmod However,observed
R7019 T7937 T7943 punct ",",observed
R7020 T7814 T7810 prep with,increased
R7021 T7938 T7939 det no,increase
R7022 T7939 T7943 nsubjpass increase,observed
R7023 T7940 T7939 prep in,increase
R7024 T7815 T7816 amod inflammasome,stimulation
R7025 T7941 T7940 pobj IL-1β,in
R7026 T7942 T7943 auxpass was,observed
R7027 T7816 T7814 pobj stimulation,with
R7028 T7943 T7943 ROOT observed,observed
R7029 T7944 T7943 prep under,observed
R7030 T7945 T7944 pobj basal,under
R7031 T7946 T7945 cc or,basal
R7032 T7817 T7816 advmod alone,stimulation
R7033 T7947 T7948 amod primed,conditions
R7034 T7948 T7945 conj conditions,basal
R7035 T7818 T7821 mark as,anticipated
R7036 T7949 T7943 punct .,observed
R7037 T7819 T7821 aux would,anticipated
R7038 T7820 T7821 auxpass be,anticipated
R7039 T7821 T7810 advcl anticipated,increased
R7040 T7950 T7957 nsubj Studies,been
R7041 T8047 T8046 pobj monocytes,of
R7042 T7951 T7950 acl investigating,Studies
R7043 T7952 T7953 det the,production
R7044 T7953 T7951 dobj production,investigating
R7045 T7954 T7953 prep of,production
R7046 T8048 T8045 prep into,differentiation
R7047 T7955 T7954 pobj IL-1β,of
R7048 T7956 T7957 aux have,been
R7049 T7957 T7957 ROOT been,been
R7050 T8049 T8048 pobj macrophages,into
R7051 T7958 T7959 advmod somewhat,inconsistent
R7052 T7959 T7957 acomp inconsistent,been
R7053 T7960 T7957 punct .,been
R7054 T8050 T8052 aux may,account
R7055 T7961 T7962 det A,study
R7056 T7962 T7970 nsubj study,provided
R7057 T7963 T7962 prep by,study
R7058 T8051 T8052 advmod partly,account
R7059 T7964 T7963 pobj Reininger,by
R7060 T8052 T8052 ROOT account,account
R7061 T7965 T7967 nmod et,[
R7062 T7966 T7967 compound al.,[
R7063 T7967 T7969 nmod [,]
R7064 T7968 T7969 nummod 43,]
R7065 T8053 T8052 prep for,account
R7066 T7969 T7970 nsubj ],provided
R7067 T7970 T7970 ROOT provided,provided
R7068 T7971 T7970 dobj evidence,provided
R7069 T8054 T8055 det the,differences
R7070 T7972 T7982 mark that,had
R7071 T7973 T7976 amod human,cells
R7072 T7974 T7976 amod bronchial,cells
R7073 T8055 T8053 pobj differences,for
R7074 T7975 T7976 amod epithelial,cells
R7075 T7976 T7982 nsubj cells,had
R7076 T7977 T7976 acl possessing,cells
R7077 T7978 T7981 det the,mutation
R7078 T7979 T7981 nmod ΔF508,mutation
R7079 T7980 T7981 amod CFTR,mutation
R7080 T8056 T8055 acl observed,differences
R7081 T7981 T7977 dobj mutation,possessing
R7082 T7982 T7971 acl had,evidence
R7083 T7983 T7986 det a,capacity
R7084 T7984 T7985 advmod slightly,reduced
R7085 T8057 T8056 prep with,observed
R7086 T7985 T7986 amod reduced,capacity
R7087 T7986 T7982 dobj capacity,had
R7088 T7987 T7988 aux to,produce
R7089 T8058 T8059 det the,study
R7090 T7988 T7986 acl produce,capacity
R7091 T7989 T7988 dobj IL-1β,produce
R7092 T8059 T8057 pobj study,with
R7093 T7990 T7982 cc and,had
R7094 T7991 T7982 conj lacked,had
R7095 T7992 T7993 det the,ability
R7096 T8060 T8056 agent by,observed
R7097 T7993 T7991 dobj ability,lacked
R7098 T7994 T7995 aux to,induce
R7099 T7995 T7993 acl induce,ability
R7100 T7996 T7999 det an,activation
R7101 T8061 T8060 pobj Kotrange,by
R7102 T7997 T7999 amod early,activation
R7103 T7998 T7999 compound NF-κB,activation
R7104 T7999 T7995 dobj activation,induce
R7105 T8062 T8052 punct .,account
R7106 T8000 T7995 prep in,induce
R7107 T8001 T8000 pobj response,in
R7108 T8002 T8001 prep to,response
R7109 T8063 T8065 amod Inflammasome-mediated,production
R7110 T8003 T8004 compound P.,aeruginosa
R7111 T8004 T8002 pobj aeruginosa,to
R7112 T8005 T7970 punct .,provided
R7113 T8064 T8065 compound IL-1β,production
R7114 T8006 T8017 advmod Conversely,found
R7115 T8007 T8017 punct ",",found
R7116 T8065 T8071 nsubj production,differ
R7117 T8008 T8009 det a,study
R7118 T8009 T8017 nsubj study,found
R7119 T8010 T8009 prep by,study
R7120 T8011 T8010 pobj Kotrange,by
R7121 T8066 T8065 prep by,production
R7122 T8012 T8013 compound et,al.
R7123 T8013 T8014 compound al.,[
R7124 T8067 T8066 pobj monocytes,by
R7125 T8014 T8009 appos [,study
R7126 T8015 T8016 nummod 31,]
R7127 T8016 T8017 nsubj ],found
R7128 T8017 T8017 ROOT found,found
R7129 T8018 T8025 mark that,produced
R7130 T8019 T8022 amod murine,macrophages
R7131 T8068 T8067 cc and,monocytes
R7132 T8020 T8022 nmod bone,macrophages
R7133 T8069 T8067 conj PBMCs,monocytes
R7134 T8070 T8071 aux does,differ
R7135 T8021 T8022 amod marrow-derived,macrophages
R7136 T8022 T8025 nsubj macrophages,produced
R7137 T8071 T8071 ROOT differ,differ
R7138 T8023 T8022 acl expressing,macrophages
R7139 T8072 T8071 prep from,differ
R7140 T8024 T8023 dobj ΔF508-CFTR,expressing
R7141 T8073 T8074 compound macrophages,[
R7142 T8074 T8072 pobj [,from
R7143 T8075 T8076 nummod 47,]
R7144 T8025 T8017 ccomp produced,found
R7145 T8076 T8074 conj ],[
R7146 T8026 T8027 amod increased,amounts
R7147 T8027 T8025 dobj amounts,produced
R7148 T8028 T8027 prep of,amounts
R7149 T8077 T8076 punct ",",]
R7150 T8029 T8028 pobj IL-1β,of
R7151 T8030 T8031 advmod when,compared
R7152 T8078 T8080 nmod [,]
R7153 T8031 T8025 advcl compared,produced
R7154 T8032 T8031 prep to,compared
R7155 T8033 T8032 pobj macrophages,to
R7156 T8079 T8080 nummod 48,]
R7157 T8034 T8033 acl expressing,macrophages
R7158 T8035 T8036 amod normal,CFTR
R7159 T8036 T8034 dobj CFTR,expressing
R7160 T8037 T8034 prep in,expressing
R7161 T8038 T8037 pobj response,in
R7162 T8039 T8038 prep to,response
R7163 T8080 T8076 conj ],]
R7164 T8040 T8042 compound Burkholderia,K56-2
R7165 T8081 T8080 punct ",",]
R7166 T8041 T8042 compound cenocepacia,K56-2
R7167 T8082 T8080 conj [,]
R7168 T8042 T8039 pobj K56-2,to
R7169 T8043 T8017 punct .,found
R7170 T8044 T8045 det The,differentiation
R7171 T8083 T8084 nummod 49,]
R7172 T8045 T8052 nsubj differentiation,account
R7173 T8046 T8045 prep of,differentiation
R7174 T8084 T8080 conj ],]
R7175 T8085 T8084 cc and,]
R7176 T8086 T8084 conj macrophages,]
R7177 T8087 T8088 auxpass are,found
R7178 T8144 T8144 ROOT contribute,contribute
R7179 T8088 T8071 conj found,differ
R7180 T8145 T8144 prep to,contribute
R7181 T8146 T8147 compound IL-1β,production
R7182 T8147 T8145 pobj production,to
R7183 T8089 T8090 aux to,have
R7184 T8148 T8144 punct .,contribute
R7185 T8149 T8157 prep For,increased
R7186 T8150 T8149 pobj example,For
R7187 T8090 T8088 xcomp have,found
R7188 T8151 T8157 punct ",",increased
R7189 T8152 T8153 compound neutrophil,counts
R7190 T8153 T8157 nsubjpass counts,increased
R7191 T8091 T8092 amod higher,expression
R7192 T8154 T8157 aux can,increased
R7193 T8155 T8157 auxpass be,increased
R7194 T8156 T8157 advmod significantly,increased
R7195 T8092 T8090 dobj expression,have
R7196 T8157 T8157 ROOT increased,increased
R7197 T8158 T8157 prep in,increased
R7198 T8093 T8092 prep of,expression
R7199 T8159 T8160 det the,lungs
R7200 T8094 T8093 pobj CFTR,of
R7201 T8160 T8158 pobj lungs,in
R7202 T8161 T8160 prep of,lungs
R7203 T8162 T8163 compound CF,patients
R7204 T8095 T8092 prep over,expression
R7205 T8163 T8161 pobj patients,of
R7206 T8164 T8166 nmod [,]
R7207 T8165 T8166 nummod 52,]
R7208 T8096 T8097 compound monocytes,[
R7209 T8166 T8157 npadvmod ],increased
R7210 T8167 T8166 punct ",",]
R7211 T8097 T8095 pobj [,over
R7212 T8168 T8166 appos [,]
R7213 T8169 T8170 nummod 53,]
R7214 T8170 T8166 conj ],]
R7215 T8098 T8099 nummod 50,]
R7216 T8171 T8170 punct ",",]
R7217 T8172 T8170 conj [,]
R7218 T8099 T8097 appos ],[
R7219 T8173 T8174 nummod 54,]
R7220 T8174 T8170 conj ],]
R7221 T8175 T8157 cc and,increased
R7222 T8100 T8071 punct .,differ
R7223 T8176 T8177 aux may,produce
R7224 T8177 T8157 conj produce,increased
R7225 T8101 T8125 advmod However,are
R7226 T8178 T8179 amod mature,IL-1β
R7227 T8179 T8177 dobj IL-1β,produce
R7228 T8180 T8177 prep through,produce
R7229 T8181 T8183 amod caspase-1,mechanisms
R7230 T8182 T8183 amod independent,mechanisms
R7231 T8183 T8180 pobj mechanisms,through
R7232 T8102 T8125 punct ",",are
R7233 T8184 T8186 nmod [,]
R7234 T8185 T8186 nummod 55,]
R7235 T8186 T8183 appos ],mechanisms
R7236 T8103 T8108 mark as,express
R7237 T8187 T8157 punct .,increased
R7238 T8188 T8189 det The,role
R7239 T8189 T8199 nsubj role,is
R7240 T8104 T8108 nsubj monocytes,express
R7241 T8190 T8189 prep of,role
R7242 T8191 T8192 amod NF-κB,activation
R7243 T8105 T8104 cc and,monocytes
R7244 T8192 T8190 pobj activation,of
R7245 T8193 T8192 prep in,activation
R7246 T8194 T8195 amod inflammasome,activation
R7247 T8195 T8193 pobj activation,in
R7248 T8106 T8107 amod other,PBMCs
R7249 T8196 T8195 cc and,activation
R7250 T8197 T8198 amod IL-1β,secretion
R7251 T8198 T8195 conj secretion,activation
R7252 T8107 T8104 conj PBMCs,monocytes
R7253 T8199 T8199 ROOT is,is
R7254 T8200 T8199 neg not,is
R7255 T8108 T8125 advcl express,are
R7256 T8201 T8199 acomp straightforward,is
R7257 T8202 T8199 punct .,is
R7258 T8203 T8205 nsubj Studies,revealed
R7259 T8204 T8205 aux have,revealed
R7260 T8109 T8110 compound CFTR,[
R7261 T8205 T8205 ROOT revealed,revealed
R7262 T8206 T8208 det an,role
R7263 T8207 T8208 amod essential,role
R7264 T8110 T8112 nmod [,]
R7265 T8208 T8205 dobj role,revealed
R7266 T8209 T8208 prep for,role
R7267 T8210 T8211 amod NF-κB,activation
R7268 T8211 T8209 pobj activation,for
R7269 T8111 T8112 nummod 50,]
R7270 T8212 T8211 prep in,activation
R7271 T8213 T8214 det the,production
R7272 T8214 T8212 pobj production,in
R7273 T8112 T8108 dobj ],express
R7274 T8215 T8214 prep of,production
R7275 T8216 T8219 amod pro-IL-1β,components
R7276 T8113 T8112 punct ",",]
R7277 T8217 T8216 cc and,pro-IL-1β
R7278 T8218 T8216 conj inflammasome,pro-IL-1β
R7279 T8219 T8215 pobj components,of
R7280 T8220 T8221 amod such,as
R7281 T8221 T8219 prep as,components
R7282 T8222 T8223 compound NLRP3,[
R7283 T8114 T8112 conj [,]
R7284 T8223 T8221 pobj [,as
R7285 T8224 T8225 nummod 22,]
R7286 T8225 T8223 conj ],[
R7287 T8226 T8225 punct ",",]
R7288 T8115 T8116 nummod 51,]
R7289 T8227 T8225 conj [,]
R7290 T8228 T8229 nummod 23,]
R7291 T8229 T8225 conj ],]
R7292 T8116 T8114 dobj ],[
R7293 T8230 T8205 punct .,revealed
R7294 T8231 T8245 prep In,increases
R7295 T8232 T8231 pobj contrast,In
R7296 T8117 T8108 cc and,express
R7297 T8233 T8245 punct ",",increases
R7298 T8234 T8245 nsubj deletion,increases
R7299 T8235 T8234 prep of,deletion
R7300 T8118 T8108 conj produce,express
R7301 T8236 T8235 pobj IKKβ,of
R7302 T8237 T8236 punct ",",IKKβ
R7303 T8119 T8120 amod large,amounts
R7304 T8238 T8239 det a,kinase
R7305 T8120 T8118 dobj amounts,produce
R7306 T8239 T8236 appos kinase,IKKβ
R7307 T8240 T8239 amod essential,kinase
R7308 T8121 T8120 prep of,amounts
R7309 T8122 T8121 pobj IL-1β,of
R7310 T8123 T8125 punct ",",are
R7311 T8124 T8125 nsubj they,are
R7312 T8241 T8240 prep in,essential
R7313 T8242 T8243 amod NF-κB,activation
R7314 T8243 T8241 pobj activation,in
R7315 T8125 T8125 ROOT are,are
R7316 T8244 T8236 punct ",",IKKβ
R7317 T8245 T8245 ROOT increases,increases
R7318 T8246 T8247 amod IL-1β,secretion
R7319 T8126 T8127 amod adequate,models
R7320 T8247 T8245 dobj secretion,increases
R7321 T8248 T8247 prep in,secretion
R7322 T8127 T8125 attr models,are
R7323 T8249 T8250 compound murine,macrophages
R7324 T8250 T8248 pobj macrophages,in
R7325 T8128 T8129 aux to,examine
R7326 T8251 T8253 nmod [,]
R7327 T8252 T8253 nummod 56,]
R7328 T8253 T8245 dobj ],increases
R7329 T8254 T8253 punct ",",]
R7330 T8255 T8257 nmod [,]
R7331 T8129 T8127 relcl examine,models
R7332 T8256 T8257 nummod 57,]
R7333 T8257 T8253 conj ],]
R7334 T8258 T8245 cc and,increases
R7335 T8259 T8245 conj demonstrates,increases
R7336 T8130 T8131 det the,effects
R7337 T8260 T8262 det a,role
R7338 T8261 T8262 amod dual,role
R7339 T8262 T8259 dobj role,demonstrates
R7340 T8131 T8129 dobj effects,examine
R7341 T8263 T8262 prep for,role
R7342 T8264 T8263 pobj NF-κB,for
R7343 T8265 T8264 prep in,NF-κB
R7344 T8266 T8265 pobj regulation,in
R7345 T8132 T8131 prep of,effects
R7346 T8267 T8266 prep of,regulation
R7347 T8268 T8267 pobj IL-1β,of
R7348 T8269 T8245 punct .,increases
R7349 T8133 T8134 amod CFTR,function
R7350 T8270 T8271 aux To,address
R7351 T8271 T8279 advcl address,quantified
R7352 T8272 T8273 det this,uncertainty
R7353 T8273 T8271 dobj uncertainty,address
R7354 T8134 T8132 pobj function,of
R7355 T8274 T8273 prep in,uncertainty
R7356 T8275 T8276 poss our,experiments
R7357 T8276 T8274 pobj experiments,in
R7358 T8135 T8131 prep on,effects
R7359 T8277 T8279 nsubj we,quantified
R7360 T8278 T8279 advmod also,quantified
R7361 T8136 T8137 compound IL-1β,production
R7362 T8279 T8279 ROOT quantified,quantified
R7363 T8280 T8279 dobj IL-8,quantified
R7364 T8281 T8280 punct ",",IL-8
R7365 T8137 T8135 pobj production,on
R7366 T8282 T8285 det an,cytokine
R7367 T8283 T8285 amod important,cytokine
R7368 T8284 T8285 compound CF,cytokine
R7369 T8285 T8280 appos cytokine,IL-8
R7370 T8138 T8125 punct .,are
R7371 T8286 T8285 cc and,cytokine
R7372 T8287 T8285 conj marker,cytokine
R7373 T8288 T8287 prep of,marker
R7374 T8139 T8141 amod Other,cells
R7375 T8289 T8290 amod NF-κB,activation
R7376 T8290 T8288 pobj activation,of
R7377 T8291 T8280 conj [,IL-8
R7378 T8292 T8293 nummod 58,]
R7379 T8293 T8280 conj ],IL-8
R7380 T8294 T8293 punct ",",]
R7381 T8140 T8141 amod hematopoeitic,cells
R7382 T8295 T8279 cc and,quantified
R7383 T8296 T8279 conj found,quantified
R7384 T8297 T8298 det no,differences
R7385 T8141 T8144 nsubj cells,contribute
R7386 T8298 T8296 dobj differences,found
R7387 T8299 T8298 prep between,differences
R7388 T8300 T8303 nmod CF,subjects
R7389 T8301 T8300 cc and,CF
R7390 T8142 T8144 aux may,contribute
R7391 T8302 T8300 conj control,CF
R7392 T8303 T8299 pobj subjects,between
R7393 T8143 T8144 advmod also,contribute
R7394 T8304 T8279 punct .,quantified
R7395 T8305 T8314 advmod Similarly,were
R7396 T8306 T8314 punct ",",were
R7397 T8338 T8334 pobj Bay11-7082,with
R7398 T8339 T8340 advmod significantly,inhibited
R7399 T8307 T8314 nsubj levels,were
R7400 T8308 T8307 prep of,levels
R7401 T8309 T8310 amod intracellular,pro-IL-1β
R7402 T8340 T8340 ROOT inhibited,inhibited
R7403 T8310 T8308 pobj pro-IL-1β,of
R7404 T8311 T8307 prep in,levels
R7405 T8312 T8313 nummod THP-1,cells
R7406 T8341 T8342 preconj both,IL-1β
R7407 T8313 T8311 pobj cells,in
R7408 T8314 T8314 ROOT were,were
R7409 T8342 T8345 amod IL-1β,secretion
R7410 T8315 T8314 acomp dependent,were
R7411 T8316 T8315 prep on,dependent
R7412 T8317 T8318 amod NF-κB,activity
R7413 T8343 T8342 cc and,IL-1β
R7414 T8318 T8316 pobj activity,on
R7415 T8344 T8342 conj IL-8,IL-1β
R7416 T8319 T8314 cc and,were
R7417 T8320 T8322 aux did,increase
R7418 T8321 T8322 neg not,increase
R7419 T8345 T8340 dobj secretion,inhibited
R7420 T8322 T8314 conj increase,were
R7421 T8346 T8349 punct (,h
R7422 T8323 T8322 prep with,increase
R7423 T8324 T8325 amod CFTRinh172,treatment
R7424 T8325 T8323 pobj treatment,with
R7425 T8347 T8348 compound Fig.,6d
R7426 T8326 T8314 punct .,were
R7427 T8327 T8328 amod Subsequent,treatment
R7428 T8348 T8349 nummod 6d,h
R7429 T8328 T8340 nsubj treatment,inhibited
R7430 T8329 T8328 prep of,treatment
R7431 T8330 T8331 nummod THP-1,cells
R7432 T8331 T8329 pobj cells,of
R7433 T8332 T8331 cc and,cells
R7434 T8333 T8331 conj PBMCs,cells
R7435 T8349 T8345 appos h,secretion
R7436 T8334 T8328 prep with,treatment
R7437 T8335 T8338 det the,Bay11-7082
R7438 T8336 T8338 amod NF-κB,Bay11-7082
R7439 T8350 T8349 punct ),h
R7440 T8351 T8340 punct .,inhibited
R7441 T8337 T8338 compound inhibitor,Bay11-7082
R7442 T8352 T8359 advmod Therefore,observed
R7443 T8353 T8359 punct ",",observed
R7444 T8354 T8355 det the,IL-1β
R7445 T8355 T8358 nmod IL-1β,responses
R7446 T8356 T8355 cc and,IL-1β
R7447 T8435 T8432 pobj response,of
R7448 T8357 T8355 conj IL-8,IL-1β
R7449 T8436 T8435 acl generated,response
R7450 T8437 T8436 agent by,generated
R7451 T8358 T8359 nsubj responses,observed
R7452 T8438 T8437 pobj live,by
R7453 T8439 T8440 mark as,opposed
R7454 T8359 T8359 ROOT observed,observed
R7455 T8440 T8438 advcl opposed,live
R7456 T8441 T8440 prep to,opposed
R7457 T8442 T8443 amod dead,bacteria
R7458 T8360 T8359 ccomp were,observed
R7459 T8443 T8441 pobj bacteria,to
R7460 T8444 T8446 nmod [,]
R7461 T8445 T8446 nummod 59,]
R7462 T8446 T8443 appos ],bacteria
R7463 T8361 T8362 advmod both,dependent
R7464 T8447 T8424 punct .,be
R7465 T8448 T8449 amod Potential,shortcomings
R7466 T8449 T8453 nsubj shortcomings,include
R7467 T8362 T8360 amod dependent,were
R7468 T8450 T8449 prep of,shortcomings
R7469 T8451 T8452 det these,experiments
R7470 T8452 T8450 pobj experiments,of
R7471 T8363 T8362 prep upon,dependent
R7472 T8453 T8453 ROOT include,include
R7473 T8454 T8455 poss its,translatability
R7474 T8455 T8453 dobj translatability,include
R7475 T8364 T8365 amod NF-κB,activation
R7476 T8456 T8455 prep to,translatability
R7477 T8457 T8458 compound lung,disease
R7478 T8458 T8456 pobj disease,to
R7479 T8459 T8458 cc and,disease
R7480 T8460 T8458 conj issues,disease
R7481 T8461 T8460 acl related,issues
R7482 T8365 T8363 pobj activation,upon
R7483 T8462 T8461 prep to,related
R7484 T8463 T8464 det the,hypermutability
R7485 T8464 T8462 pobj hypermutability,to
R7486 T8366 T8359 punct .,observed
R7487 T8465 T8464 prep of,hypermutability
R7488 T8466 T8467 compound P.,aeruginosa
R7489 T8467 T8465 pobj aeruginosa,of
R7490 T8468 T8461 prep during,related
R7491 T8367 T8376 csubj Priming,is
R7492 T8469 T8470 det the,evolution
R7493 T8470 T8468 pobj evolution,during
R7494 T8471 T8470 prep of,evolution
R7495 T8368 T8367 prep with,Priming
R7496 T8472 T8473 amod chronic,infection
R7497 T8473 T8471 pobj infection,of
R7498 T8369 T8371 amod heat-killed,aeruginosa
R7499 T8474 T8453 punct .,include
R7500 T8475 T8486 mark Although,reflect
R7501 T8370 T8371 compound P.,aeruginosa
R7502 T8476 T8477 det the,responses
R7503 T8371 T8368 pobj aeruginosa,with
R7504 T8477 T8486 nsubj responses,reflect
R7505 T8478 T8477 acl measured,responses
R7506 T8372 T8371 punct ",",aeruginosa
R7507 T8479 T8478 prep in,measured
R7508 T8480 T8482 amod peripheral,cells
R7509 T8481 T8482 compound blood,cells
R7510 T8373 T8371 prep like,aeruginosa
R7511 T8482 T8479 pobj cells,in
R7512 T8483 T8486 aux may,reflect
R7513 T8484 T8486 neg not,reflect
R7514 T8374 T8373 pobj LPS,like
R7515 T8485 T8486 advmod completely,reflect
R7516 T8486 T8496 advcl reflect,have
R7517 T8375 T8376 punct ",",is
R7518 T8487 T8488 det the,responses
R7519 T8488 T8486 dobj responses,reflect
R7520 T8489 T8488 acl occurring,responses
R7521 T8376 T8376 ROOT is,is
R7522 T8490 T8489 prep in,occurring
R7523 T8491 T8493 det the,lung
R7524 T8492 T8493 compound CF,lung
R7525 T8493 T8490 pobj lung,in
R7526 T8377 T8376 acomp unable,is
R7527 T8494 T8496 punct ",",have
R7528 T8495 T8496 nsubj PBMCs,have
R7529 T8496 T8496 ROOT have,have
R7530 T8497 T8498 det a,number
R7531 T8498 T8496 dobj number,have
R7532 T8499 T8498 prep of,number
R7533 T8378 T8379 aux to,induce
R7534 T8500 T8501 amod useful,advantages
R7535 T8501 T8499 pobj advantages,of
R7536 T8502 T8498 punct :,number
R7537 T8503 T8498 punct (,number
R7538 T8379 T8377 xcomp induce,unable
R7539 T8504 T8498 appos i,number
R7540 T8505 T8498 punct ),number
R7541 T8506 T8507 nsubj PBMCs,are
R7542 T8380 T8383 det a,response
R7543 T8507 T8507 ROOT are,are
R7544 T8508 T8507 neg not,are
R7545 T8509 T8507 acomp subject,are
R7546 T8381 T8383 amod strong,response
R7547 T8510 T8509 prep to,subject
R7548 T8511 T8510 pobj alterations,to
R7549 T8512 T8514 nsubj that,emerge
R7550 T8382 T8383 amod IL-1β,response
R7551 T8513 T8514 aux may,emerge
R7552 T8514 T8511 relcl emerge,alterations
R7553 T8515 T8514 prep from,emerge
R7554 T8383 T8379 dobj response,induce
R7555 T8516 T8518 amod long-term,culture
R7556 T8517 T8518 compound cell,culture
R7557 T8518 T8515 pobj culture,from
R7558 T8519 T8514 punct ",",emerge
R7559 T8384 T8385 mark as,compared
R7560 T8520 T8514 advcl cloning,emerge
R7561 T8521 T8520 cc and,cloning
R7562 T8385 T8376 advcl compared,is
R7563 T8522 T8520 conj immortalization,cloning
R7564 T8523 T8522 punct ",",immortalization
R7565 T8524 T8522 cc and,immortalization
R7566 T8386 T8387 aux to,live
R7567 T8525 T8526 punct (,ii
R7568 T8387 T8385 xcomp live,compared
R7569 T8526 T8522 conj ii,immortalization
R7570 T8527 T8522 punct ),immortalization
R7571 T8388 T8389 compound P.,aeruginosa
R7572 T8528 T8529 nsubj PBMCs,express
R7573 T8529 T8507 conj express,are
R7574 T8530 T8532 det a,repertoire
R7575 T8389 T8387 dobj aeruginosa,live
R7576 T8531 T8532 amod large,repertoire
R7577 T8390 T8389 punct (,aeruginosa
R7578 T8391 T8389 appos Fig.,aeruginosa
R7579 T8532 T8529 dobj repertoire,express
R7580 T8533 T8532 prep of,repertoire
R7581 T8534 T8536 amod innate,receptors
R7582 T8535 T8536 amod immune,receptors
R7583 T8392 T8391 nummod 6c,Fig.
R7584 T8536 T8533 pobj receptors,of
R7585 T8537 T8529 cc and,express
R7586 T8538 T8529 conj secrete,express
R7587 T8393 T8389 punct ),aeruginosa
R7588 T8539 T8541 det a,array
R7589 T8540 T8541 amod broad,array
R7590 T8541 T8538 dobj array,secrete
R7591 T8394 T8376 punct ",",is
R7592 T8542 T8541 prep of,array
R7593 T8543 T8542 pobj cytokines,of
R7594 T8544 T8543 cc and,cytokines
R7595 T8395 T8376 cc but,is
R7596 T8545 T8543 conj chemokines,cytokines
R7597 T8546 T8541 acl allowing,array
R7598 T8547 T8548 amod comprehensive,analysis
R7599 T8396 T8376 conj generated,is
R7600 T8548 T8546 dobj analysis,allowing
R7601 T8549 T8548 prep of,analysis
R7602 T8550 T8551 det the,modulation
R7603 T8397 T8401 amod greater,activation
R7604 T8551 T8549 pobj modulation,of
R7605 T8552 T8551 prep of,modulation
R7606 T8553 T8554 amod inflammatory,responses
R7607 T8554 T8552 pobj responses,of
R7608 T8398 T8400 compound NF-κB,AP-1
R7609 T8555 T8554 prep by,responses
R7610 T8399 T8400 compound /,AP-1
R7611 T8556 T8555 pobj CFTR,by
R7612 T8400 T8401 compound AP-1,activation
R7613 T8557 T8507 punct .,are
R7614 T8558 T8562 nsubjpass Consideration,given
R7615 T8559 T8562 aux must,given
R7616 T8401 T8396 dobj activation,generated
R7617 T8560 T8562 advmod also,given
R7618 T8561 T8562 auxpass be,given
R7619 T8562 T8562 ROOT given,given
R7620 T8402 T8404 punct (,6a
R7621 T8563 T8562 dative to,given
R7622 T8564 T8565 det the,nature
R7623 T8403 T8404 compound Fig.,6a
R7624 T8565 T8563 pobj nature,to
R7625 T8566 T8565 prep of,nature
R7626 T8567 T8569 nmod P.,infection
R7627 T8404 T8401 appos 6a,activation
R7628 T8568 T8569 compound aeruginosa,infection
R7629 T8569 T8566 pobj infection,of
R7630 T8570 T8569 cc and,infection
R7631 T8571 T8572 amod genotypic,changes
R7632 T8572 T8569 conj changes,infection
R7633 T8573 T8572 prep in,changes
R7634 T8405 T8401 punct ),activation
R7635 T8574 T8575 compound P.,aeruginosa
R7636 T8575 T8573 pobj aeruginosa,in
R7637 T8576 T8578 mark as,progresses
R7638 T8577 T8578 nsubj infection,progresses
R7639 T8406 T8401 cc and,activation
R7640 T8578 T8562 advcl progresses,given
R7641 T8579 T8562 punct .,given
R7642 T8580 T8581 compound P.,aeruginosa
R7643 T8407 T8408 amod IL-8,secretion
R7644 T8581 T8582 nsubj aeruginosa,mediates
R7645 T8582 T8582 ROOT mediates,mediates
R7646 T8583 T8584 amod inflammasome,activation
R7647 T8408 T8401 conj secretion,activation
R7648 T8584 T8582 dobj activation,mediates
R7649 T8585 T8584 prep through,activation
R7650 T8586 T8590 poss its,system
R7651 T8409 T8410 punct (,Fig.
R7652 T8587 T8590 compound type,system
R7653 T8588 T8590 nmod III,system
R7654 T8589 T8590 compound secretion,system
R7655 T8410 T8401 appos Fig.,activation
R7656 T8590 T8585 pobj system,through
R7657 T8591 T8590 punct (,system
R7658 T8592 T8590 appos T3SS,system
R7659 T8411 T8410 nummod 6b,Fig.
R7660 T8593 T8590 punct ),system
R7661 T8594 T8584 cc and,activation
R7662 T8595 T8600 det the,]
R7663 T8412 T8410 punct ),Fig.
R7664 T8596 T8598 nmod NLRC4,[
R7665 T8597 T8598 compound inflammasome,[
R7666 T8598 T8600 nmod [,]
R7667 T8413 T8401 prep than,activation
R7668 T8599 T8600 nummod 19,]
R7669 T8600 T8584 conj ],activation
R7670 T8601 T8600 punct ",",]
R7671 T8414 T8415 amod live,bacteria
R7672 T8602 T8600 conj [,]
R7673 T8603 T8604 nummod 20,]
R7674 T8604 T8600 conj ],]
R7675 T8415 T8413 pobj bacteria,than
R7676 T8605 T8582 punct .,mediates
R7677 T8606 T8612 advmod However,established
R7678 T8607 T8612 punct ",",established
R7679 T8416 T8396 prep despite,generated
R7680 T8608 T8612 nsubj clones,established
R7681 T8609 T8608 prep of,clones
R7682 T8610 T8611 compound P.,aeruginosa
R7683 T8611 T8609 pobj aeruginosa,of
R7684 T8612 T8612 ROOT established,established
R7685 T8417 T8416 pobj stimulation,despite
R7686 T8613 T8612 prep during,established
R7687 T8614 T8615 amod chronic,infection
R7688 T8615 T8613 pobj infection,during
R7689 T8418 T8417 prep at,stimulation
R7690 T8616 T8617 aux may,accumulate
R7691 T8617 T8612 conj accumulate,established
R7692 T8618 T8617 dobj mutations,accumulate
R7693 T8619 T8618 prep in,mutations
R7694 T8419 T8420 amod equivalent,MOIs
R7695 T8620 T8621 compound virulence,factors
R7696 T8621 T8619 pobj factors,in
R7697 T8622 T8623 amod such,as
R7698 T8420 T8418 pobj MOIs,at
R7699 T8623 T8621 prep as,factors
R7700 T8624 T8625 compound exsA,[
R7701 T8625 T8627 nmod [,]
R7702 T8421 T8376 punct .,is
R7703 T8626 T8627 nummod 60,]
R7704 T8627 T8623 pobj ],as
R7705 T8628 T8612 punct .,established
R7706 T8422 T8424 nsubj This,be
R7707 T8423 T8424 aux may,be
R7708 T8424 T8424 ROOT be,be
R7709 T8425 T8424 acomp indicative,be
R7710 T8629 T8645 prep By,confirmed
R7711 T8630 T8629 pcomp employing,By
R7712 T8426 T8425 prep of,indicative
R7713 T8631 T8632 det a,deletion
R7714 T8632 T8630 dobj deletion,employing
R7715 T8633 T8632 amod mutant,deletion
R7716 T8634 T8632 prep in,deletion
R7717 T8427 T8429 det the,degree
R7718 T8428 T8429 amod different,degree
R7719 T8635 T8634 pobj exsA,in
R7720 T8429 T8426 pobj degree,of
R7721 T8636 T8635 punct ",",exsA
R7722 T8637 T8639 det the,regulator
R7723 T8638 T8639 amod key,regulator
R7724 T8430 T8429 cc and,degree
R7725 T8639 T8635 appos regulator,exsA
R7726 T8640 T8639 prep in,regulator
R7727 T8641 T8642 nummod T3SS,transcription
R7728 T8431 T8429 conj quality,degree
R7729 T8642 T8640 pobj transcription,in
R7730 T8643 T8645 punct ",",confirmed
R7731 T8644 T8645 nsubj we,confirmed
R7732 T8645 T8645 ROOT confirmed,confirmed
R7733 T8646 T8649 mark that,is
R7734 T8432 T8431 prep of,quality
R7735 T8647 T8648 det the,T3SS
R7736 T8648 T8649 nsubj T3SS,is
R7737 T8649 T8645 ccomp is,confirmed
R7738 T8650 T8649 acomp important,is
R7739 T8433 T8435 det the,response
R7740 T8651 T8650 prep for,important
R7741 T8652 T8653 amod IL-1β,secretion
R7742 T8653 T8651 pobj secretion,for
R7743 T8434 T8435 amod inflammatory,response
R7744 T8654 T8655 punct (,Fig.
R7745 T8655 T8649 npadvmod Fig.,is
R7746 T8656 T8655 nummod 5a,Fig.
R7747 T8726 T8725 cc and,ATP
R7748 T8657 T8655 appos b,Fig.
R7749 T8658 T8655 punct ),Fig.
R7750 T8659 T8655 punct ",",Fig.
R7751 T8660 T8649 cc and,is
R7752 T8727 T8728 compound P.,aeruginosa
R7753 T8661 T8676 mark that,be
R7754 T8662 T8676 advcl depending,be
R7755 T8663 T8662 prep on,depending
R7756 T8728 T8725 conj aeruginosa,ATP
R7757 T8664 T8665 det the,adaptation
R7758 T8665 T8663 pobj adaptation,on
R7759 T8666 T8665 prep in,adaptation
R7760 T8667 T8666 pobj type,in
R7761 T8729 T8697 punct .,are
R7762 T8668 T8669 compound III,secretion
R7763 T8669 T8662 dep secretion,depending
R7764 T8670 T8676 punct ",",be
R7765 T8730 T8733 advmod Furthermore,find
R7766 T8671 T8674 det the,response
R7767 T8672 T8674 compound host,response
R7768 T8673 T8674 compound IL-1β,response
R7769 T8731 T8733 punct ",",find
R7770 T8674 T8676 nsubj response,be
R7771 T8675 T8676 aux may,be
R7772 T8676 T8649 conj be,is
R7773 T8732 T8733 nsubj we,find
R7774 T8677 T8676 advmod up,be
R7775 T8678 T8677 cc or,up
R7776 T8679 T8682 amod downregulated,]
R7777 T8733 T8733 ROOT find,find
R7778 T8680 T8682 nmod [,]
R7779 T8681 T8682 nummod 19,]
R7780 T8682 T8676 attr ],be
R7781 T8683 T8682 punct ",",]
R7782 T8684 T8686 nmod [,]
R7783 T8734 T8735 amod little,evidence
R7784 T8685 T8686 nummod 60,]
R7785 T8686 T8682 conj ],]
R7786 T8687 T8686 punct ",",]
R7787 T8688 T8686 conj [,]
R7788 T8735 T8733 dobj evidence,find
R7789 T8689 T8690 nummod 61,]
R7790 T8690 T8686 conj ],]
R7791 T8736 T8737 aux to,support
R7792 T8691 T8645 punct .,confirmed
R7793 T8692 T8697 prep In,are
R7794 T8693 T8692 pobj conclusion,In
R7795 T8694 T8697 punct ",",are
R7796 T8695 T8696 poss our,data
R7797 T8696 T8697 nsubj data,are
R7798 T8697 T8697 ROOT are,are
R7799 T8698 T8697 acomp consistent,are
R7800 T8699 T8698 prep with,consistent
R7801 T8700 T8701 det a,role
R7802 T8701 T8699 pobj role,with
R7803 T8702 T8701 prep for,role
R7804 T8703 T8704 amod hematopoietic,cells
R7805 T8704 T8702 pobj cells,for
R7806 T8705 T8701 punct ",",role
R7807 T8706 T8707 neg not,airway
R7808 T8707 T8697 attr airway,are
R7809 T8708 T8709 amod epithelial,cells
R7810 T8737 T8735 relcl support,evidence
R7811 T8709 T8707 dobj cells,airway
R7812 T8710 T8707 punct ",",airway
R7813 T8711 T8707 prep as,airway
R7814 T8738 T8742 det an,response
R7815 T8712 T8714 det the,source
R7816 T8713 T8714 amod major,source
R7817 T8739 T8742 amod increased,response
R7818 T8714 T8711 pobj source,as
R7819 T8740 T8742 amod IL-1β,response
R7820 T8715 T8714 prep of,source
R7821 T8716 T8718 amod inflammasome-mediated,production
R7822 T8741 T8742 amod inflammatory,response
R7823 T8717 T8718 compound IL-1β,production
R7824 T8718 T8715 pobj production,of
R7825 T8742 T8737 dobj response,support
R7826 T8719 T8718 prep in,production
R7827 T8720 T8721 det the,lungs
R7828 T8721 T8719 pobj lungs,in
R7829 T8743 T8742 prep to,response
R7830 T8722 T8714 prep in,source
R7831 T8723 T8722 pobj response,in
R7832 T8724 T8723 prep to,response
R7833 T8725 T8724 pobj ATP,to
R7834 T8744 T8747 compound NF-κB,stimulation
R7835 T8745 T8746 compound /,Inflammasome
R7836 T8746 T8747 compound Inflammasome,stimulation
R7837 T8747 T8743 pobj stimulation,to
R7838 T8748 T8747 prep in,stimulation
R7839 T8749 T8750 compound CF,patients
R7840 T8750 T8748 pobj patients,in
R7841 T8751 T8733 punct .,find
R7842 T8752 T8753 amod Further,studies
R7843 T8753 T8755 nsubjpass studies,warranted
R7844 T8754 T8755 auxpass are,warranted
R7845 T8755 T8755 ROOT warranted,warranted
R7846 T8756 T8757 aux to,determine
R7847 T8757 T8755 advcl determine,warranted
R7848 T8758 T8779 mark if,correlated
R7849 T8759 T8779 nsubjpass adaptations,correlated
R7850 T8760 T8759 prep of,adaptations
R7851 T8761 T8762 compound P.,aeruginosa
R7852 T8762 T8760 pobj aeruginosa,of
R7853 T8763 T8759 prep during,adaptations
R7854 T8764 T8765 det the,course
R7855 T8765 T8763 pobj course,during
R7856 T8766 T8765 prep of,course
R7857 T8767 T8769 amod chronic,infection
R7858 T8768 T8769 compound lung,infection
R7859 T8769 T8770 compound infection,alters
R7860 T8770 T8772 nmod alters,activation
R7861 T8771 T8772 amod inflammasome,activation
R7862 T8772 T8766 pobj activation,of
R7863 T8773 T8759 punct ",",adaptations
R7864 T8774 T8759 cc and,adaptations
R7865 T8775 T8779 mark whether,correlated
R7866 T8776 T8779 nsubjpass this,correlated
R7867 T8777 T8779 aux can,correlated
R7868 T8778 T8779 auxpass be,correlated
R7869 T8779 T8757 advcl correlated,determine
R7870 T8780 T8779 prep with,correlated
R7871 T8781 T8782 compound disease,severity
R7872 T8782 T8780 pobj severity,with
R7873 T8783 T8782 prep in,severity
R7874 T8784 T8783 pobj CF.,in