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PMC:3317373 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T315 0-3 DT denotes The
T316 4-11 NN denotes Absence
T317 12-14 IN denotes of
T318 15-19 NNP denotes Nrf2
T319 20-28 NNP denotes Enhances
T320 29-44 NNP denotes NF-κB-Dependent
T321 45-57 NNP denotes Inflammation
T322 58-67 VBG denotes following
T323 68-75 NNP denotes Scratch
T324 76-82 NNP denotes Injury
T325 83-85 IN denotes in
T326 86-91 NNP denotes Mouse
T327 92-99 JJ denotes Primary
T328 100-108 NNP denotes Cultured
T329 109-119 NNPS denotes Astrocytes
T330 130-132 PRP denotes It
T331 133-136 VBZ denotes has
T332 137-141 VBN denotes been
T333 142-148 VBN denotes proved
T334 149-153 IN denotes that
T335 154-158 JJ denotes Nrf2
T336 159-168 NN denotes depletion
T337 169-177 VBZ denotes enhances
T338 178-190 JJ denotes inflammatory
T339 191-198 NN denotes process
T340 199-206 IN denotes through
T341 207-217 NN denotes activation
T342 218-220 IN denotes of
T343 221-226 NN denotes NF-κB
T344 227-229 IN denotes in
T345 230-233 DT denotes the
T346 234-239 NN denotes brain
T347 240-245 IN denotes after
T348 246-249 NNP denotes TBI
T349 249-250 , denotes ,
T350 251-254 CC denotes but
T351 255-261 RB denotes little
T352 262-264 VBZ denotes is
T353 265-270 VBN denotes known
T354 271-276 IN denotes about
T355 277-280 DT denotes the
T356 281-293 NN denotes relationship
T357 294-301 IN denotes between
T358 302-306 NNP denotes Nrf2
T359 307-310 CC denotes and
T360 311-316 NNP denotes NF-κB
T361 317-319 IN denotes in
T362 320-330 NNS denotes astrocytes
T363 331-336 IN denotes after
T364 337-340 NNP denotes TBI
T365 340-341 . denotes .
T366 342-347 RB denotes Hence
T367 347-348 , denotes ,
T368 349-351 PRP denotes we
T369 352-356 VBD denotes used
T370 357-364 JJ denotes primary
T371 365-373 JJ denotes cultured
T372 374-384 NNS denotes astrocytes
T373 385-389 IN denotes from
T374 390-396 DT denotes either
T375 397-401 JJ denotes Nrf2
T376 402-410 NN denotes wildtype
T377 411-413 CC denotes or
T378 414-422 NN denotes knockout
T379 423-427 NNS denotes mice
T380 428-430 TO denotes to
T381 431-436 VB denotes study
T382 437-440 DT denotes the
T383 441-450 NN denotes influence
T384 451-453 IN denotes of
T385 454-458 NNP denotes Nrf2
T386 459-461 IN denotes on
T387 462-465 DT denotes the
T388 466-476 NN denotes activation
T389 477-479 IN denotes of
T390 480-485 NNP denotes NF-κB
T391 486-489 CC denotes and
T392 490-500 NN denotes expression
T393 501-503 IN denotes of
T394 504-519 JJ denotes proinflammatory
T395 520-529 NNS denotes cytokines
T396 530-532 IN denotes in
T397 533-534 DT denotes a
T398 535-540 NN denotes model
T399 541-543 IN denotes of
T400 544-547 NNP denotes TBI
T401 548-550 IN denotes in
T402 551-556 NN denotes vitro
T403 556-557 . denotes .
T404 558-565 JJ denotes Primary
T405 566-574 JJ denotes cultured
T406 575-585 NNS denotes astrocytes
T407 586-590 VBD denotes were
T408 591-600 VBN denotes scratched
T409 601-603 TO denotes to
T410 604-609 VB denotes mimic
T411 610-613 DT denotes the
T412 614-623 JJ denotes traumatic
T413 624-630 NN denotes injury
T414 631-633 IN denotes in
T415 634-639 NN denotes vitro
T416 639-640 . denotes .
T417 641-645 RB denotes Then
T418 646-649 DT denotes the
T419 650-661 JJ denotes DNA-binding
T420 662-670 NN denotes activity
T421 671-673 IN denotes of
T422 674-679 NN denotes NF-κB
T423 680-683 VBD denotes was
T424 684-693 VBN denotes evaluated
T425 694-696 IN denotes by
T426 697-701 NNP denotes EMSA
T427 701-702 . denotes .
T428 703-706 DT denotes The
T429 707-711 NNP denotes mRNA
T430 712-715 CC denotes and
T431 716-723 NN denotes protein
T432 724-730 NNS denotes levels
T433 731-733 IN denotes of
T434 734-739 NNP denotes TNF-α
T435 739-740 , denotes ,
T436 741-746 NNP denotes IL-1β
T437 746-747 , denotes ,
T438 748-752 NNP denotes IL-6
T439 752-753 , denotes ,
T440 754-757 CC denotes and
T441 758-762 NNP denotes MMP9
T442 763-767 VBD denotes were
T443 768-772 RB denotes also
T444 773-782 VBN denotes evaluated
T445 782-783 . denotes .
T446 784-791 NN denotes Gelatin
T447 792-802 NN denotes zymography
T448 803-806 VBD denotes was
T449 807-816 VBN denotes performed
T450 817-819 TO denotes to
T451 820-826 VB denotes detect
T452 827-830 DT denotes the
T453 831-839 NN denotes activity
T454 840-842 IN denotes of
T455 843-847 NNP denotes MMP9
T456 847-848 . denotes .
T457 849-852 DT denotes The
T458 853-861 NN denotes activity
T459 862-864 IN denotes of
T460 865-870 NNP denotes NF-κB
T461 871-874 CC denotes and
T462 875-885 NN denotes expression
T463 886-888 IN denotes of
T464 889-904 JJ denotes proinflammatory
T465 905-914 NNS denotes cytokines
T466 915-924 VBN denotes mentioned
T467 925-930 IN denotes above
T468 931-935 VBD denotes were
T469 936-947 VBN denotes upregulated
T470 948-950 IN denotes at
T471 951-953 CD denotes 24
T472 954-955 NN denotes h
T473 956-961 IN denotes after
T474 962-969 NN denotes scratch
T475 969-970 . denotes .
T476 971-974 DT denotes The
T477 975-985 NN denotes expression
T478 986-989 CC denotes and
T479 990-998 NN denotes activity
T480 999-1001 IN denotes of
T481 1002-1006 CD denotes MMP9
T482 1007-1011 VBD denotes were
T483 1012-1016 RB denotes also
T484 1017-1025 VBN denotes elevated
T485 1025-1026 . denotes .
T486 1027-1030 CC denotes And
T487 1031-1035 JJ denotes such
T488 1036-1044 NN denotes tendency
T489 1045-1048 VBD denotes was
T490 1049-1053 RB denotes much
T491 1054-1058 JJR denotes more
T492 1059-1068 JJ denotes prominent
T493 1069-1071 IN denotes in
T494 1072-1076 NNP denotes Nrf2
T495 1077-1079 NNP denotes KO
T496 1080-1090 NNS denotes astrocytes
T497 1091-1095 IN denotes than
T498 1096-1100 DT denotes that
T499 1101-1103 IN denotes in
T500 1104-1106 NNP denotes WT
T501 1107-1117 NNS denotes astrocytes
T502 1117-1118 . denotes .
T503 1119-1124 DT denotes These
T504 1125-1132 NNS denotes results
T505 1133-1140 VBP denotes suggest
T506 1141-1145 IN denotes that
T507 1146-1149 DT denotes the
T508 1150-1157 NN denotes absence
T509 1158-1160 IN denotes of
T510 1161-1165 NNP denotes Nrf2
T511 1166-1169 MD denotes may
T512 1170-1176 VB denotes induce
T513 1177-1181 RBR denotes more
T514 1182-1192 JJ denotes aggressive
T515 1193-1205 NN denotes inflammation
T516 1206-1213 IN denotes through
T517 1214-1224 NN denotes activation
T518 1225-1227 IN denotes of
T519 1228-1233 NNP denotes NF-κB
T520 1234-1237 CC denotes and
T521 1238-1248 JJ denotes downstream
T522 1249-1264 JJ denotes proinflammatory
T523 1265-1274 NNS denotes cytokines
T524 1275-1277 IN denotes in
T525 1278-1288 NNS denotes astrocytes
T526 1288-1289 . denotes .
T917 1307-1312 NN denotes Brain
T918 1313-1319 NN denotes damage
T919 1320-1329 VBG denotes following
T920 1330-1339 JJ denotes traumatic
T921 1340-1346 NN denotes injury
T922 1347-1349 VBZ denotes is
T923 1350-1351 DT denotes a
T924 1352-1358 NN denotes result
T925 1359-1361 IN denotes of
T926 1362-1368 JJ denotes direct
T927 1369-1370 -LRB- denotes (
T928 1370-1377 JJ denotes primary
T929 1378-1384 NN denotes injury
T930 1384-1385 -RRB- denotes )
T931 1386-1389 CC denotes and
T932 1390-1398 JJ denotes indirect
T933 1399-1400 -LRB- denotes (
T934 1400-1409 JJ denotes secondary
T935 1410-1412 CC denotes or
T936 1413-1420 JJ denotes delayed
T937 1421-1427 NN denotes injury
T938 1427-1428 -RRB- denotes )
T939 1429-1439 NNS denotes mechanisms
T940 1439-1440 . denotes .
T941 1441-1444 DT denotes The
T942 1445-1454 JJ denotes secondary
T943 1455-1461 NN denotes injury
T944 1462-1471 NN denotes mechanism
T945 1472-1480 VBZ denotes involves
T946 1481-1484 DT denotes the
T947 1485-1495 NN denotes initiation
T948 1496-1498 IN denotes of
T949 1499-1501 DT denotes an
T950 1502-1507 JJ denotes acute
T951 1508-1520 JJ denotes inflammatory
T952 1521-1529 NN denotes response
T953 1529-1530 , denotes ,
T954 1531-1540 VBG denotes including
T955 1541-1550 NN denotes breakdown
T956 1551-1553 IN denotes of
T957 1554-1565 JJ denotes blood-brain
T958 1566-1573 NN denotes barrier
T959 1574-1575 -LRB- denotes (
T960 1575-1578 NNP denotes BBB
T961 1578-1579 -RRB- denotes )
T962 1579-1580 , denotes ,
T963 1581-1586 NN denotes brain
T964 1587-1592 NN denotes edema
T965 1592-1593 , denotes ,
T966 1594-1606 NN denotes infiltration
T967 1607-1609 IN denotes of
T968 1610-1620 JJ denotes peripheral
T969 1621-1626 NN denotes blood
T970 1627-1632 NNS denotes cells
T971 1632-1633 , denotes ,
T972 1634-1637 CC denotes and
T973 1638-1648 NN denotes activation
T974 1649-1651 IN denotes of
T975 1652-1660 NN denotes resident
T976 1661-1676 JJ denotes immunocompetent
T977 1677-1682 NNS denotes cells
T978 1682-1683 , denotes ,
T979 1684-1686 RB denotes as
T980 1687-1691 RB denotes well
T981 1692-1694 IN denotes as
T982 1695-1698 DT denotes the
T983 1699-1706 NN denotes release
T984 1707-1709 IN denotes of
T985 1710-1718 JJ denotes numerous
T986 1719-1725 JJ denotes immune
T987 1726-1735 NNS denotes mediators
T988 1736-1740 JJ denotes such
T989 1741-1743 IN denotes as
T990 1744-1756 NNS denotes interleukins
T991 1757-1760 CC denotes and
T992 1761-1772 JJ denotes chemotactic
T993 1773-1780 NNS denotes factors
T994 1781-1782 VBP denotes [
T995 1782-1783 CD denotes 1
T996 1783-1784 NNP denotes ]
T997 1784-1785 . denotes .
T998 1786-1789 CC denotes And
T999 1790-1793 DT denotes the
T1000 1794-1804 JJ denotes subsequent
T1001 1805-1817 NN denotes inflammation
T1002 1818-1823 VBZ denotes leads
T1003 1824-1826 TO denotes to
T1004 1827-1836 JJ denotes secondary
T1005 1837-1843 NN denotes damage
T1006 1844-1847 RB denotes not
T1007 1848-1852 RB denotes only
T1008 1853-1855 IN denotes in
T1009 1856-1861 NN denotes brain
T1010 1862-1865 CC denotes but
T1011 1866-1870 RB denotes also
T1012 1871-1873 IN denotes in
T1013 1874-1879 JJ denotes other
T1014 1880-1886 NNS denotes organs
T1015 1887-1888 VBP denotes [
T1016 1888-1889 CD denotes 2
T1017 1890-1891 CD denotes 4
T1018 1891-1892 NNP denotes ]
T1019 1892-1893 . denotes .
T1020 1894-1901 NNP denotes Nuclear
T1021 1902-1908 NN denotes factor
T1022 1909-1918 VBD denotes erythroid
T1023 1919-1928 JJ denotes 2-related
T1024 1929-1936 CD denotes factor2
T1025 1937-1938 -LRB- denotes (
T1026 1938-1942 NN denotes Nrf2
T1027 1942-1943 -RRB- denotes )
T1028 1944-1946 VBZ denotes is
T1029 1947-1948 DT denotes a
T1030 1949-1962 NN denotes transcription
T1031 1963-1969 NN denotes factor
T1032 1970-1974 WDT denotes that
T1033 1975-1984 VBZ denotes regulates
T1034 1985-1989 JJ denotes many
T1035 1990-1995 NNS denotes kinds
T1036 1996-1998 IN denotes of
T1037 1999-2010 JJ denotes antioxidant
T1038 2011-2016 NNS denotes genes
T1039 2016-2017 . denotes .
T1040 2018-2025 JJ denotes Several
T1041 2026-2033 NNS denotes studies
T1042 2034-2038 VBP denotes have
T1043 2039-2051 VBN denotes demonstrated
T1044 2052-2056 IN denotes that
T1045 2057-2061 JJ denotes Nrf2
T1046 2062-2071 VBZ denotes regulates
T1047 2072-2075 DT denotes the
T1048 2076-2088 NN denotes inflammation
T1049 2089-2091 IN denotes in
T1050 2092-2095 DT denotes the
T1051 2096-2101 NN denotes brain
T1052 2102-2107 IN denotes after
T1053 2108-2117 JJ denotes traumatic
T1054 2118-2123 NN denotes brain
T1055 2124-2130 NN denotes injury
T1056 2131-2132 -LRB- denotes (
T1057 2132-2135 NNP denotes TBI
T1058 2135-2136 -RRB- denotes )
T1059 2136-2137 . denotes .
T1060 2138-2140 PRP denotes It
T1061 2141-2144 VBD denotes was
T1062 2145-2149 RB denotes also
T1063 2150-2156 VBN denotes showed
T1064 2157-2161 IN denotes that
T1065 2162-2165 NNP denotes TBI
T1066 2166-2171 MD denotes could
T1067 2172-2178 VB denotes induce
T1068 2179-2183 RBR denotes more
T1069 2184-2194 VBN denotes aggravated
T1070 2195-2201 NN denotes damage
T1071 2202-2204 IN denotes in
T1072 2205-2209 JJ denotes Nrf2
T1073 2210-2218 NN denotes knockout
T1074 2219-2223 NNS denotes mice
T1075 2224-2228 IN denotes than
T1076 2229-2231 IN denotes in
T1077 2232-2240 NN denotes wildtype
T1078 2241-2245 NNS denotes mice
T1079 2246-2247 VBP denotes [
T1080 2247-2248 CD denotes 5
T1081 2248-2249 NNP denotes ]
T1082 2249-2250 . denotes .
T1083 2251-2253 IN denotes On
T1084 2254-2257 DT denotes the
T1085 2258-2266 NN denotes contrary
T1086 2266-2267 , denotes ,
T1087 2268-2272 JJ denotes such
T1088 2273-2285 NN denotes inflammation
T1089 2286-2289 MD denotes can
T1090 2290-2292 VB denotes be
T1091 2293-2303 VBN denotes extenuated
T1092 2304-2311 IN denotes through
T1093 2312-2321 VBG denotes elevating
T1094 2322-2325 DT denotes the
T1095 2326-2331 NN denotes level
T1096 2332-2334 IN denotes of
T1097 2335-2339 JJ denotes Nrf2
T1098 2340-2342 IN denotes by
T1099 2343-2346 PRP$ denotes its
T1100 2347-2355 NNS denotes inducers
T1101 2355-2356 , denotes ,
T1102 2357-2361 JJ denotes such
T1103 2362-2364 IN denotes as
T1104 2365-2377 NN denotes sulforaphane
T1105 2378-2379 -LRB- denotes (
T1106 2379-2382 NNP denotes SFN
T1107 2382-2383 -RRB- denotes )
T1108 2384-2385 NNP denotes [
T1109 2385-2386 CD denotes 6
T1110 2386-2387 NNP denotes ]
T1111 2387-2388 . denotes .
T1112 2389-2391 PRP denotes It
T1113 2392-2394 VBZ denotes is
T1114 2395-2399 RB denotes well
T1115 2400-2410 VBN denotes documented
T1116 2411-2415 IN denotes that
T1117 2416-2426 NNS denotes astrocytes
T1118 2427-2431 VBP denotes play
T1119 2432-2433 DT denotes a
T1120 2434-2442 JJ denotes critical
T1121 2443-2447 NN denotes role
T1122 2448-2450 IN denotes in
T1123 2451-2462 VBG denotes maintaining
T1124 2463-2469 JJ denotes normal
T1125 2470-2475 NN denotes brain
T1126 2476-2486 NN denotes physiology
T1127 2487-2490 CC denotes and
T1128 2491-2501 VBG denotes responding
T1129 2502-2504 TO denotes to
T1130 2505-2511 NN denotes injury
T1131 2512-2514 CC denotes or
T1132 2515-2522 NN denotes disease
T1133 2522-2523 . denotes .
T1134 2524-2526 IN denotes In
T1135 2527-2531 NN denotes fact
T1136 2531-2532 , denotes ,
T1137 2533-2536 PDT denotes all
T1138 2537-2540 DT denotes the
T1139 2541-2555 JJ denotes aforementioned
T1140 2556-2563 NNS denotes studies
T1141 2564-2567 VBP denotes are
T1142 2568-2577 VBN denotes performed
T1143 2578-2580 IN denotes in
T1144 2581-2585 NN denotes vivo
T1145 2585-2586 . denotes .
T1146 2587-2593 NNP denotes Little
T1147 2594-2596 VBZ denotes is
T1148 2597-2602 VBN denotes known
T1149 2603-2608 IN denotes about
T1150 2609-2612 DT denotes the
T1151 2613-2625 NN denotes relationship
T1152 2626-2633 IN denotes between
T1153 2634-2638 NNP denotes Nrf2
T1154 2639-2642 CC denotes and
T1155 2643-2655 NN denotes inflammation
T1156 2656-2658 IN denotes in
T1157 2659-2669 NNS denotes astrocytes
T1158 2670-2675 IN denotes after
T1159 2676-2679 NNP denotes TBI
T1160 2679-2680 . denotes .
T1161 2681-2690 RB denotes Therefore
T1162 2690-2691 , denotes ,
T1163 2692-2696 RB denotes here
T1164 2697-2699 PRP denotes we
T1165 2700-2708 VBD denotes analysed
T1166 2709-2712 DT denotes the
T1167 2713-2722 NN denotes influence
T1168 2723-2725 IN denotes of
T1169 2726-2730 NNP denotes Nrf2
T1170 2731-2733 IN denotes on
T1171 2734-2737 DT denotes the
T1172 2738-2748 NN denotes expression
T1173 2749-2751 IN denotes of
T1174 2752-2767 JJ denotes proinflammatory
T1175 2768-2777 NNS denotes cytokines
T1176 2778-2780 IN denotes in
T1177 2781-2788 JJ denotes primary
T1178 2789-2797 JJ denotes cultured
T1179 2798-2808 NNS denotes astrocytes
T1180 2809-2813 IN denotes from
T1181 2814-2824 JJ denotes transgenic
T1182 2825-2829 NNS denotes mice
T1183 2830-2835 IN denotes after
T1184 2836-2843 NN denotes scratch
T1185 2844-2850 NN denotes injury
T1186 2850-2851 . denotes .
T1507 2879-2882 CD denotes 2.1
T1508 2882-2883 . denotes .
T1509 2884-2891 JJ denotes Primary
T1510 2892-2899 NNP denotes Culture
T1511 2900-2903 CC denotes and
T1512 2904-2918 NNP denotes Identification
T1513 2919-2921 IN denotes of
T1514 2922-2927 NNP denotes Mouse
T1515 2928-2938 NNP denotes Astrocytes
T1516 2939-2943 NNP denotes Nrf2
T1517 2944-2952 NN denotes knockout
T1518 2953-2956 NNP denotes ICR
T1519 2957-2961 NNS denotes mice
T1520 2962-2966 VBD denotes were
T1521 2967-2973 RB denotes kindly
T1522 2974-2982 VBN denotes provided
T1523 2983-2985 IN denotes by
T1524 2986-2989 NNP denotes Dr.
T1525 2990-2996 NNP denotes Thomas
T1526 2997-2999 NNP denotes W.
T1527 3000-3007 NNP denotes Kensler
T1528 3008-3009 -LRB- denotes (
T1529 3009-3014 NNP denotes Johns
T1530 3015-3022 NNP denotes Hopkins
T1531 3023-3033 NNP denotes University
T1532 3033-3034 , denotes ,
T1533 3035-3044 NNP denotes Baltimore
T1534 3044-3045 , denotes ,
T1535 3046-3048 NNP denotes MD
T1536 3048-3049 , denotes ,
T1537 3050-3053 NNP denotes USA
T1538 3053-3054 -RRB- denotes )
T1539 3054-3055 . denotes .
T1540 3056-3063 JJ denotes Primary
T1541 3064-3074 NNS denotes astrocytes
T1542 3075-3079 VBD denotes were
T1543 3080-3088 VBN denotes obtained
T1544 3089-3093 IN denotes from
T1545 3094-3103 JJ denotes postnatal
T1546 3104-3113 JJ denotes 2-day-old
T1547 3114-3118 JJ denotes Nrf2
T1548 3119-3123 JJ denotes wide
T1549 3124-3128 NN denotes type
T1550 3129-3130 -LRB- denotes (
T1551 3130-3132 NNP denotes WT
T1552 3132-3133 -RRB- denotes )
T1553 3134-3137 CC denotes and
T1554 3138-3146 NN denotes knockout
T1555 3147-3148 -LRB- denotes (
T1556 3148-3150 NNP denotes KO
T1557 3150-3151 -RRB- denotes )
T1558 3152-3156 NNS denotes mice
T1559 3157-3158 -LRB- denotes (
T1560 3158-3159 CD denotes 6
T1561 3160-3164 NNS denotes mice
T1562 3165-3168 IN denotes for
T1563 3169-3173 DT denotes each
T1564 3174-3182 NN denotes genotype
T1565 3182-3183 -RRB- denotes )
T1566 3183-3184 . denotes .
T1567 3185-3194 VBG denotes Following
T1568 3195-3207 NN denotes decapitation
T1569 3207-3208 , denotes ,
T1570 3209-3212 DT denotes the
T1571 3213-3221 NNS denotes cortices
T1572 3222-3226 VBD denotes were
T1573 3227-3236 VBN denotes dissected
T1574 3237-3240 RP denotes out
T1575 3240-3241 , denotes ,
T1576 3242-3245 CC denotes and
T1577 3246-3249 DT denotes the
T1578 3250-3258 NNS denotes meninges
T1579 3259-3262 CC denotes and
T1580 3263-3273 VBN denotes associated
T1581 3274-3279 NN denotes blood
T1582 3280-3287 NNS denotes vessels
T1583 3288-3292 VBD denotes were
T1584 3293-3300 VBN denotes removed
T1585 3300-3301 . denotes .
T1586 3302-3305 DT denotes The
T1587 3306-3312 NN denotes tissue
T1588 3313-3316 VBD denotes was
T1589 3317-3324 RB denotes roughly
T1590 3325-3332 VBN denotes chopped
T1591 3333-3337 IN denotes with
T1592 3338-3339 DT denotes a
T1593 3340-3347 NN denotes scalpel
T1594 3348-3353 NN denotes blade
T1595 3353-3354 , denotes ,
T1596 3355-3364 VBN denotes incubated
T1597 3365-3367 IN denotes in
T1598 3368-3371 CD denotes 0.5
T1599 3371-3372 NN denotes %
T1600 3373-3380 NN denotes trypsin
T1601 3381-3384 IN denotes for
T1602 3385-3387 CD denotes 10
T1603 3388-3395 NNS denotes minutes
T1604 3396-3398 IN denotes at
T1605 3399-3401 CD denotes 37
T1606 3401-3402 CD denotes °
T1607 3402-3403 NNP denotes C
T1608 3403-3404 , denotes ,
T1609 3405-3408 CC denotes and
T1610 3409-3417 VBD denotes agitated
T1611 3418-3423 DT denotes every
T1612 3424-3427 JJ denotes few
T1613 3428-3435 NNS denotes minutes
T1614 3435-3436 . denotes .
T1615 3437-3442 IN denotes After
T1616 3443-3452 NN denotes digestion
T1617 3452-3453 , denotes ,
T1618 3454-3457 DT denotes the
T1619 3458-3464 NN denotes tissue
T1620 3465-3468 VBD denotes was
T1621 3469-3475 VBN denotes rinsed
T1622 3476-3481 RB denotes twice
T1623 3482-3484 IN denotes in
T1624 3485-3489 NNP denotes DMEM
T1625 3490-3494 IN denotes with
T1626 3495-3497 CD denotes 10
T1627 3497-3498 NN denotes %
T1628 3499-3502 NNP denotes FBS
T1629 3502-3503 , denotes ,
T1630 3504-3512 VBN denotes followed
T1631 3513-3515 IN denotes by
T1632 3516-3517 DT denotes a
T1633 3518-3528 JJ denotes mechanical
T1634 3529-3541 NN denotes dissociation
T1635 3542-3544 IN denotes in
T1636 3545-3549 NNP denotes DMEM
T1637 3550-3554 IN denotes with
T1638 3555-3557 CD denotes 20
T1639 3557-3558 NN denotes %
T1640 3559-3562 NNP denotes FBS
T1641 3563-3566 CC denotes and
T1642 3567-3568 CD denotes 5
T1643 3569-3577 JJ denotes units/mL
T1644 3578-3588 NN denotes penicillin
T1645 3588-3589 , denotes ,
T1646 3590-3591 CD denotes 5
T1647 3592-3594 NN denotes μg
T1648 3594-3595 NN denotes /
T1649 3595-3597 NNP denotes mL
T1650 3598-3610 NNP denotes streptomycin
T1651 3611-3612 -LRB- denotes (
T1652 3612-3620 JJ denotes complete
T1653 3621-3628 NN denotes culture
T1654 3629-3635 NN denotes medium
T1655 3635-3636 -RRB- denotes )
T1656 3636-3637 . denotes .
T1657 3638-3643 IN denotes After
T1658 3644-3654 NN denotes incubation
T1659 3655-3658 IN denotes for
T1660 3659-3660 CD denotes 1
T1661 3661-3662 NN denotes h
T1662 3662-3663 , denotes ,
T1663 3664-3667 DT denotes the
T1664 3668-3679 NN denotes supernatant
T1665 3680-3683 VBD denotes was
T1666 3684-3695 VBN denotes transferred
T1667 3696-3698 TO denotes to
T1668 3699-3700 DT denotes a
T1669 3701-3704 JJ denotes new
T1670 3705-3710 NN denotes flask
T1671 3711-3713 CC denotes or
T1672 3714-3718 NN denotes dish
T1673 3719-3720 -LRB- denotes (
T1674 3720-3726 NNP denotes Costar
T1675 3726-3727 , denotes ,
T1676 3728-3731 NNP denotes USA
T1677 3731-3732 -RRB- denotes )
T1678 3733-3736 IN denotes for
T1679 3737-3746 VBG denotes depleting
T1680 3747-3750 DT denotes the
T1681 3751-3759 JJ denotes residual
T1682 3760-3770 JJ denotes epithelial
T1683 3771-3776 NNS denotes cells
T1684 3776-3777 . denotes .
T1685 3778-3782 RB denotes Then
T1686 3783-3786 DT denotes the
T1687 3787-3792 NNS denotes cells
T1688 3793-3797 VBD denotes were
T1689 3798-3808 VBN denotes cultivated
T1690 3809-3811 IN denotes at
T1691 3812-3814 CD denotes 37
T1692 3814-3815 CD denotes °
T1693 3815-3816 NNP denotes C
T1694 3817-3821 IN denotes with
T1695 3822-3823 CD denotes 5
T1696 3823-3824 NN denotes %
T1697 3825-3828 CD denotes CO2
T1698 3828-3829 . denotes .
T1699 3830-3833 CC denotes And
T1700 3834-3837 DT denotes the
T1701 3838-3846 JJ denotes complete
T1702 3847-3854 NN denotes culture
T1703 3855-3861 NN denotes medium
T1704 3862-3865 VBD denotes was
T1705 3866-3878 JJ denotes half-changed
T1706 3879-3884 RB denotes twice
T1707 3885-3886 DT denotes a
T1708 3887-3891 NN denotes week
T1709 3891-3892 . denotes .
T1710 3893-3903 NNP denotes Astrocytes
T1711 3904-3912 VBD denotes expanded
T1712 3913-3916 IN denotes for
T1713 3917-3922 IN denotes about
T1714 3923-3924 CD denotes 7
T1715 3925-3929 NNS denotes days
T1716 3930-3932 TO denotes to
T1717 3933-3938 VB denotes reach
T1718 3939-3949 NN denotes confluence
T1719 3949-3950 . denotes .
T1720 3951-3955 RB denotes Then
T1721 3956-3959 DT denotes the
T1722 3960-3966 NNS denotes flasks
T1723 3967-3969 CC denotes or
T1724 3970-3976 NNS denotes dishes
T1725 3977-3981 VBD denotes were
T1726 3982-3988 VBN denotes shaken
T1727 3989-3991 IN denotes at
T1728 3992-3995 CD denotes 150
T1729 3996-3999 NN denotes rpm
T1730 4000-4003 IN denotes for
T1731 4004-4005 CD denotes 4
T1732 4006-4007 NN denotes h
T1733 4008-4010 TO denotes to
T1734 4011-4018 VB denotes deplete
T1735 4019-4022 DT denotes the
T1736 4023-4032 NN denotes microglia
T1737 4033-4036 CC denotes and
T1738 4037-4041 JJR denotes less
T1739 4042-4050 JJ denotes adherent
T1740 4051-4056 NNS denotes cells
T1741 4057-4061 IN denotes from
T1742 4062-4065 DT denotes the
T1743 4066-4074 NNS denotes cultures
T1744 4074-4075 . denotes .
T1745 4076-4081 IN denotes After
T1746 4082-4089 VBG denotes shaking
T1747 4089-4090 , denotes ,
T1748 4091-4094 DT denotes the
T1749 4095-4104 VBG denotes resulting
T1750 4105-4113 NNS denotes cultures
T1751 4114-4118 VBD denotes were
T1752 4119-4125 RB denotes mainly
T1753 4126-4136 NNS denotes astrocytes
T1754 4136-4137 , denotes ,
T1755 4138-4143 WDT denotes which
T1756 4144-4148 VBD denotes were
T1757 4149-4159 VBN denotes determined
T1758 4160-4162 IN denotes by
T1759 4163-4179 NN denotes immunoreactivity
T1760 4180-4183 IN denotes for
T1761 4184-4188 NNP denotes GFAP
T1762 4189-4190 -LRB- denotes (
T1763 4190-4199 JJ denotes sc-166481
T1764 4199-4200 , denotes ,
T1765 4201-4206 NNP denotes Santa
T1766 4207-4211 NNP denotes Cruz
T1767 4212-4225 NNP denotes Biotechnology
T1768 4225-4226 , denotes ,
T1769 4227-4229 NNP denotes CA
T1770 4229-4230 , denotes ,
T1771 4231-4234 NNP denotes USA
T1772 4234-4235 -RRB- denotes )
T1773 4235-4236 . denotes .
T1774 4237-4242 NNS denotes Cells
T1775 4243-4251 VBD denotes passaged
T1776 4252-4255 IN denotes for
T1777 4256-4259 CD denotes 2-3
T1778 4260-4271 NNS denotes generations
T1779 4272-4276 VBD denotes were
T1780 4277-4281 VBN denotes used
T1781 4282-4284 IN denotes in
T1782 4285-4288 DT denotes the
T1783 4289-4298 JJ denotes following
T1784 4299-4306 NNS denotes studies
T1785 4306-4307 . denotes .
T1921 4309-4312 CD denotes 2.2
T1922 4312-4313 . denotes .
T1923 4314-4316 IN denotes In
T1924 4317-4322 NNP denotes Vitro
T1925 4323-4328 NNP denotes Model
T1926 4329-4331 IN denotes of
T1927 4332-4335 NNP denotes TBI
T1928 4336-4347 VBN denotes Established
T1929 4348-4350 IN denotes by
T1930 4351-4358 NNP denotes Scratch
T1931 4359-4365 NNP denotes Injury
T1932 4366-4375 NNP denotes Astrocyte
T1933 4376-4383 NN denotes scratch
T1934 4384-4390 NN denotes injury
T1935 4391-4394 VBD denotes was
T1936 4395-4404 VBN denotes performed
T1937 4405-4407 IN denotes as
T1938 4408-4410 IN denotes in
T1939 4411-4412 DT denotes a
T1940 4413-4421 JJ denotes previous
T1941 4422-4428 NN denotes report
T1942 4429-4430 NN denotes [
T1943 4430-4431 CD denotes 7
T1944 4431-4432 NNP denotes ]
T1945 4432-4433 . denotes .
T1946 4434-4444 NNS denotes Astrocytes
T1947 4445-4449 VBD denotes were
T1948 4450-4457 VBN denotes planted
T1949 4458-4460 IN denotes in
T1950 4461-4467 JJ denotes 6-well
T1951 4468-4474 NNS denotes plates
T1952 4475-4478 CC denotes and
T1953 4479-4484 VBN denotes grown
T1954 4485-4487 TO denotes to
T1955 4488-4498 NN denotes confluence
T1956 4498-4499 . denotes .
T1957 4500-4503 DT denotes The
T1958 4504-4508 NN denotes cell
T1959 4509-4518 NN denotes monolayer
T1960 4519-4522 VBD denotes was
T1961 4523-4532 VBN denotes scratched
T1962 4533-4537 IN denotes with
T1963 4538-4539 DT denotes a
T1964 4540-4547 JJ denotes sterile
T1965 4548-4551 JJ denotes 26G
T1966 4552-4559 NN denotes syringe
T1967 4560-4566 NN denotes needle
T1968 4566-4567 , denotes ,
T1969 4568-4577 VBG denotes resulting
T1970 4578-4580 IN denotes in
T1971 4581-4584 DT denotes the
T1972 4585-4594 NN denotes formation
T1973 4595-4597 IN denotes of
T1974 4598-4599 DT denotes a
T1975 4600-4603 CD denotes 0.5
T1976 4604-4606 NN denotes mm
T1977 4607-4611 JJ denotes wide
T1978 4612-4615 NN denotes gap
T1979 4615-4616 . denotes .
T1980 4617-4628 RB denotes Immediately
T1981 4629-4634 IN denotes after
T1982 4635-4642 NN denotes scratch
T1983 4642-4643 , denotes ,
T1984 4644-4649 NNS denotes cells
T1985 4650-4654 VBD denotes were
T1986 4655-4661 VBN denotes washed
T1987 4662-4667 RB denotes twice
T1988 4668-4672 IN denotes with
T1989 4673-4680 JJ denotes sterile
T1990 4681-4684 NNP denotes PBS
T1991 4684-4685 , denotes ,
T1992 4686-4694 VBN denotes cultured
T1993 4695-4699 IN denotes with
T1994 4700-4708 JJ denotes complete
T1995 4709-4716 NN denotes culture
T1996 4717-4723 NN denotes medium
T1997 4723-4724 , denotes ,
T1998 4725-4728 CC denotes and
T1999 4729-4734 VBN denotes named
T2000 4735-4737 IN denotes as
T2001 4738-4741 NNP denotes TBI
T2002 4742-4747 NN denotes group
T2003 4747-4748 . denotes .
T2004 4749-4754 NNS denotes Cells
T2005 4754-4755 , denotes ,
T2006 4756-4761 WDT denotes which
T2007 4762-4765 VBD denotes did
T2008 4766-4769 RB denotes not
T2009 4770-4778 VBN denotes received
T2010 4779-4786 NN denotes scratch
T2011 4786-4787 , denotes ,
T2012 4788-4792 VBD denotes were
T2013 4793-4797 VBN denotes used
T2014 4798-4800 IN denotes as
T2015 4801-4806 JJ denotes blank
T2016 4807-4814 NN denotes control
T2017 4815-4818 CC denotes and
T2018 4819-4824 VBN denotes named
T2019 4825-4827 IN denotes as
T2020 4828-4832 NN denotes sham
T2021 4833-4838 NN denotes group
T2022 4838-4839 . denotes .
T2171 4841-4844 CD denotes 2.3
T2172 4844-4845 . denotes .
T2173 4846-4850 NNP denotes Cell
T2174 4851-4856 NNP denotes Death
T2175 4857-4868 NNP denotes Measurement
T2176 4869-4871 IN denotes by
T2177 4872-4877 NNP denotes CCK-8
T2178 4878-4883 NNP denotes Assay
T2179 4884-4885 CD denotes 1
T2180 4886-4887 CD denotes ×
T2181 4888-4896 JJ denotes 103/well
T2182 4897-4902 NNS denotes cells
T2183 4903-4907 VBD denotes were
T2184 4908-4914 VBN denotes seeded
T2185 4915-4917 TO denotes to
T2186 4918-4925 JJ denotes 96-well
T2187 4926-4933 NN denotes culture
T2188 4934-4940 NNS denotes plates
T2189 4941-4944 CC denotes and
T2190 4945-4955 VBN denotes cultivated
T2191 4956-4959 IN denotes for
T2192 4960-4962 CD denotes 24
T2193 4963-4964 NN denotes h
T2194 4965-4967 TO denotes to
T2195 4968-4974 VB denotes adhere
T2196 4974-4975 . denotes .
T2197 4976-4980 RB denotes Then
T2198 4981-4984 DT denotes the
T2199 4985-4989 NN denotes cell
T2200 4990-4993 VBD denotes was
T2201 4994-5001 VBN denotes scrated
T2202 5002-5004 IN denotes as
T2203 5005-5014 VBN denotes mentioned
T2204 5015-5020 IN denotes above
T2205 5020-5021 . denotes .
T2206 5022-5031 NNP denotes Astrocyte
T2207 5032-5036 NN denotes cell
T2208 5037-5042 NN denotes death
T2209 5043-5046 VBD denotes was
T2210 5047-5055 VBN denotes assessed
T2211 5056-5058 IN denotes by
T2212 5059-5063 NN denotes cell
T2213 5064-5072 VBG denotes counting
T2214 5073-5078 JJ denotes kit-8
T2215 5079-5080 -LRB- denotes (
T2216 5080-5085 NN denotes CCK-8
T2217 5085-5086 -RRB- denotes )
T2218 5087-5088 -LRB- denotes (
T2219 5088-5095 NNP denotes Dojindo
T2220 5095-5096 , denotes ,
T2221 5097-5102 NNP denotes Japan
T2222 5102-5103 -RRB- denotes )
T2223 5104-5109 NN denotes assay
T2224 5110-5112 CD denotes 24
T2225 5113-5114 NN denotes h
T2226 5115-5120 IN denotes after
T2227 5121-5128 NN denotes scratch
T2228 5129-5138 VBG denotes according
T2229 5139-5141 TO denotes to
T2230 5142-5145 DT denotes the
T2231 5146-5158 NN denotes manufacturer
T2232 5158-5160 POS denotes 's
T2233 5161-5169 NN denotes protocol
T2234 5169-5170 . denotes .
T2235 5171-5178 RB denotes Briefly
T2236 5178-5179 , denotes ,
T2237 5180-5182 CD denotes 10
T2238 5183-5185 NNP denotes μL
T2239 5186-5191 NNP denotes CCK-8
T2240 5192-5195 VBD denotes was
T2241 5196-5201 VBN denotes added
T2242 5202-5206 IN denotes into
T2243 5207-5212 DT denotes every
T2244 5213-5217 NN denotes well
T2245 5218-5221 CC denotes and
T2246 5222-5231 VBN denotes incubated
T2247 5232-5235 IN denotes for
T2248 5236-5237 CD denotes 1
T2249 5238-5239 NN denotes h
T2250 5239-5240 . denotes .
T2251 5241-5245 RB denotes Then
T2252 5246-5248 NNP denotes OD
T2253 5249-5254 NN denotes value
T2254 5255-5258 VBD denotes was
T2255 5259-5263 VBN denotes read
T2256 5264-5266 IN denotes at
T2257 5267-5270 CD denotes 450
T2258 5271-5273 NN denotes nm
T2259 5274-5279 VBG denotes using
T2260 5280-5281 DT denotes a
T2261 5282-5289 NNP denotes Bio-Rad
T2262 5290-5295 NNP denotes ELISA
T2263 5296-5306 NN denotes microplate
T2264 5307-5313 NN denotes reader
T2265 5314-5315 -LRB- denotes (
T2266 5315-5322 NNP denotes Bio-Rad
T2267 5323-5335 NNPS denotes Laboratories
T2268 5335-5336 , denotes ,
T2269 5337-5339 NNP denotes CA
T2270 5339-5340 , denotes ,
T2271 5341-5344 NNP denotes USA
T2272 5344-5345 -RRB- denotes )
T2273 5345-5346 . denotes .
T2274 5347-5350 DT denotes All
T2275 5351-5363 NNS denotes measurements
T2276 5364-5368 VBD denotes were
T2277 5369-5378 VBN denotes performed
T2278 5379-5381 IN denotes in
T2279 5382-5394 NN denotes sextuplicate
T2280 5394-5395 . denotes .
T2281 5396-5403 NNS denotes Results
T2282 5404-5408 VBD denotes were
T2283 5409-5418 VBN denotes expressed
T2284 5419-5421 IN denotes as
T2285 5422-5426 NN denotes mean
T2286 5427-5429 IN denotes of
T2287 5430-5432 NNP denotes OD
T2288 5433-5438 NN denotes value
T2289 5439-5441 IN denotes at
T2290 5442-5445 CD denotes 450
T2291 5446-5448 NN denotes nm
T2292 5449-5450 NN denotes ±
T2293 5451-5453 NNP denotes SD
T2294 5453-5454 . denotes .
T2674 5456-5459 CD denotes 2.4
T2675 5459-5460 . denotes .
T2676 5461-5476 NNP denotes Electrophoretic
T2677 5477-5485 NNP denotes Mobility
T2678 5486-5491 NNP denotes Shift
T2679 5492-5497 NNP denotes Assay
T2680 5498-5499 -LRB- denotes (
T2681 5499-5503 NNP denotes EMSA
T2682 5503-5504 -RRB- denotes )
T2683 5505-5515 NNPS denotes Monolayers
T2684 5516-5518 IN denotes of
T2685 5519-5529 NNS denotes astrocytes
T2686 5530-5534 VBD denotes were
T2687 5535-5541 VBN denotes washed
T2688 5542-5546 IN denotes with
T2689 5547-5550 NNP denotes PBS
T2690 5551-5554 CC denotes and
T2691 5555-5564 VBN denotes harvested
T2692 5565-5567 IN denotes by
T2693 5568-5576 VBG denotes scraping
T2694 5577-5581 IN denotes into
T2695 5582-5586 JJ denotes cold
T2696 5587-5590 NNP denotes PBS
T2697 5590-5591 . denotes .
T2698 5592-5595 DT denotes The
T2699 5596-5600 NN denotes cell
T2700 5601-5607 NN denotes pellet
T2701 5608-5616 VBN denotes obtained
T2702 5617-5619 IN denotes by
T2703 5620-5634 NN denotes centrifugation
T2704 5635-5638 VBD denotes was
T2705 5639-5650 VBN denotes resuspended
T2706 5651-5653 IN denotes in
T2707 5654-5660 NN denotes buffer
T2708 5661-5671 VBG denotes containing
T2709 5672-5674 CD denotes 10
T2710 5675-5677 NNP denotes mM
T2711 5678-5683 NNP denotes HEPES
T2712 5684-5685 -LRB- denotes (
T2713 5685-5687 NNP denotes pH
T2714 5688-5691 CD denotes 7.9
T2715 5691-5692 -RRB- denotes )
T2716 5692-5693 , denotes ,
T2717 5694-5696 CD denotes 10
T2718 5697-5699 NNP denotes mM
T2719 5700-5703 NNP denotes KCl
T2720 5703-5704 , denotes ,
T2721 5705-5708 CD denotes 0.1
T2722 5709-5711 NNP denotes mM
T2723 5712-5716 NNP denotes EDTA
T2724 5716-5717 , denotes ,
T2725 5718-5721 CD denotes 0.1
T2726 5722-5724 NNP denotes mM
T2727 5725-5729 NNP denotes EGTA
T2728 5729-5730 , denotes ,
T2729 5731-5734 CD denotes 1.0
T2730 5735-5737 NNP denotes mM
T2731 5738-5741 NNP denotes DTT
T2732 5741-5742 , denotes ,
T2733 5743-5746 CC denotes and
T2734 5747-5750 CD denotes 0.5
T2735 5751-5753 NNP denotes mM
T2736 5754-5774 NN denotes phenylmethylsulfonyl
T2737 5775-5783 NN denotes fluoride
T2738 5783-5784 . denotes .
T2739 5785-5789 RB denotes Then
T2740 5790-5792 CD denotes 10
T2741 5792-5793 NN denotes %
T2742 5794-5801 NNP denotes Nonidet
T2743 5802-5806 NNP denotes P-40
T2744 5807-5810 VBD denotes was
T2745 5811-5816 VBN denotes added
T2746 5817-5820 CC denotes and
T2747 5821-5829 VBN denotes vortexed
T2748 5830-5837 NN denotes briefly
T2749 5837-5838 , denotes ,
T2750 5839-5842 CC denotes and
T2751 5843-5846 DT denotes the
T2752 5847-5853 NNS denotes nuclei
T2753 5854-5858 VBD denotes were
T2754 5859-5867 VBN denotes pelleted
T2755 5868-5870 IN denotes by
T2756 5871-5885 NN denotes centrifugation
T2757 5885-5886 . denotes .
T2758 5887-5890 DT denotes The
T2759 5891-5898 JJ denotes nuclear
T2760 5899-5907 NNS denotes proteins
T2761 5908-5912 VBD denotes were
T2762 5913-5922 VBN denotes extracted
T2763 5923-5927 IN denotes with
T2764 5928-5934 NN denotes buffer
T2765 5935-5945 VBG denotes containing
T2766 5946-5948 CD denotes 20
T2767 5949-5951 NNP denotes mM
T2768 5952-5957 NNP denotes HEPES
T2769 5958-5959 -LRB- denotes (
T2770 5959-5961 NNP denotes pH
T2771 5962-5965 CD denotes 7.9
T2772 5965-5966 -RRB- denotes )
T2773 5966-5967 , denotes ,
T2774 5968-5971 CD denotes 0.4
T2775 5972-5974 NNP denotes mM
T2776 5975-5979 NNP denotes NaCl
T2777 5979-5980 , denotes ,
T2778 5981-5984 CD denotes 1.0
T2779 5985-5987 NNP denotes mM
T2780 5988-5992 NNP denotes EDTA
T2781 5992-5993 , denotes ,
T2782 5994-5997 CD denotes 1.0
T2783 5998-6000 NNP denotes mM
T2784 6001-6005 NNP denotes EGTA
T2785 6005-6006 , denotes ,
T2786 6007-6010 CD denotes 1.0
T2787 6011-6013 NNP denotes mM
T2788 6014-6017 NNP denotes DTT
T2789 6017-6018 , denotes ,
T2790 6019-6022 CC denotes and
T2791 6023-6026 CD denotes 1.0
T2792 6027-6029 NNP denotes mM
T2793 6030-6050 NN denotes phenylmethylsulfonyl
T2794 6051-6059 NN denotes fluoride
T2795 6059-6060 . denotes .
T2796 6061-6070 NNP denotes Insoluble
T2797 6071-6079 NN denotes material
T2798 6080-6083 VBD denotes was
T2799 6084-6091 VBN denotes removed
T2800 6092-6094 IN denotes by
T2801 6095-6109 NN denotes centrifugation
T2802 6110-6112 IN denotes at
T2803 6113-6118 CD denotes 14000
T2804 6119-6122 NN denotes rpm
T2805 6122-6123 , denotes ,
T2806 6124-6127 CC denotes and
T2807 6128-6131 DT denotes the
T2808 6132-6143 JJ denotes supernatant
T2809 6144-6154 VBG denotes containing
T2810 6155-6158 DT denotes the
T2811 6159-6166 JJ denotes nuclear
T2812 6167-6175 NNS denotes proteins
T2813 6176-6179 VBD denotes was
T2814 6180-6186 VBN denotes stored
T2815 6187-6189 IN denotes at
T2816 6191-6193 CD denotes 80
T2817 6193-6194 CD denotes °
T2818 6194-6195 NNP denotes C
T2819 6196-6201 IN denotes until
T2820 6202-6205 NN denotes use
T2821 6205-6206 . denotes .
T2822 6207-6214 NN denotes Protein
T2823 6215-6228 NN denotes concentration
T2824 6229-6232 VBD denotes was
T2825 6233-6243 VBN denotes determined
T2826 6244-6249 VBG denotes using
T2827 6250-6251 DT denotes a
T2828 6252-6265 JJ denotes bicinchoninic
T2829 6266-6270 NN denotes acid
T2830 6271-6276 NN denotes assay
T2831 6277-6280 NN denotes kit
T2832 6281-6285 IN denotes with
T2833 6286-6292 JJ denotes bovine
T2834 6293-6298 NN denotes serum
T2835 6299-6306 NN denotes albumin
T2836 6307-6309 IN denotes as
T2837 6310-6313 DT denotes the
T2838 6314-6322 NN denotes standard
T2839 6323-6324 -LRB- denotes (
T2840 6324-6330 NNP denotes Pierce
T2841 6331-6343 NNP denotes Biochemicals
T2842 6343-6344 , denotes ,
T2843 6345-6353 NNP denotes Rockford
T2844 6353-6354 , denotes ,
T2845 6355-6357 NNP denotes IL
T2846 6357-6358 , denotes ,
T2847 6359-6362 NNP denotes USA
T2848 6362-6363 -RRB- denotes )
T2849 6363-6364 . denotes .
T2850 6365-6369 NNP denotes EMSA
T2851 6370-6373 VBD denotes was
T2852 6374-6383 VBN denotes performed
T2853 6384-6389 VBG denotes using
T2854 6390-6393 NN denotes gel
T2855 6394-6399 NN denotes shift
T2856 6400-6405 NN denotes assay
T2857 6406-6412 NN denotes system
T2858 6413-6414 -LRB- denotes (
T2859 6414-6421 NNP denotes Promega
T2860 6421-6422 , denotes ,
T2861 6423-6430 NNP denotes Madison
T2862 6430-6431 , denotes ,
T2863 6432-6434 NNP denotes WI
T2864 6434-6435 , denotes ,
T2865 6436-6439 NNP denotes USA
T2866 6439-6440 -RRB- denotes )
T2867 6440-6441 . denotes .
T2868 6442-6451 NNP denotes Consensus
T2869 6452-6467 NN denotes oligonucleotide
T2870 6468-6473 NN denotes probe
T2871 6474-6475 -LRB- denotes (
T2872 6475-6476 CD denotes 5
T2873 6476-6477 SYM denotes ′
T2874 6477-6478 : denotes -
T2875 6478-6502 NN denotes AGTTGAGGGGACTTTCCCAGGG-3
T2876 6502-6503 NN denotes ′
T2877 6503-6504 -RRB- denotes )
T2878 6505-6508 VBD denotes was
T2879 6509-6520 VBN denotes end-labeled
T2880 6521-6523 IN denotes by
T2881 6524-6541 NN denotes T4-polynucleotide
T2882 6542-6548 NN denotes kinase
T2883 6549-6554 VBG denotes using
T2884 6555-6556 NNP denotes [
T2885 6556-6561 NNP denotes γ-32P
T2886 6561-6562 NNP denotes ]
T2887 6562-6563 : denotes -
T2888 6563-6566 NNP denotes ATP
T2889 6567-6568 -LRB- denotes (
T2890 6568-6572 NNP denotes Free
T2891 6573-6581 NNP denotes Biotech.
T2892 6581-6582 , denotes ,
T2893 6583-6590 NNP denotes Beijing
T2894 6590-6591 , denotes ,
T2895 6592-6597 NNP denotes China
T2896 6597-6598 -RRB- denotes )
T2897 6598-6599 . denotes .
T2898 6600-6607 NNP denotes Nuclear
T2899 6608-6615 NN denotes protein
T2900 6616-6617 -LRB- denotes (
T2901 6617-6619 CD denotes 20
T2902 6620-6622 NN denotes μg
T2903 6622-6623 -RRB- denotes )
T2904 6624-6627 VBD denotes was
T2905 6628-6640 VBN denotes preincubated
T2906 6641-6643 IN denotes in
T2907 6644-6646 CD denotes 20
T2908 6647-6649 NN denotes μL
T2909 6650-6657 JJ denotes binding
T2910 6658-6664 NN denotes buffer
T2911 6665-6675 VBG denotes containing
T2912 6676-6678 CD denotes 10
T2913 6679-6681 NNP denotes mM
T2914 6682-6690 NNP denotes Tris-HCl
T2915 6691-6692 -LRB- denotes (
T2916 6692-6694 NNP denotes PH
T2917 6695-6698 CD denotes 7.5
T2918 6698-6699 -RRB- denotes )
T2919 6699-6700 , denotes ,
T2920 6701-6702 CD denotes 1
T2921 6703-6705 NNP denotes mM
T2922 6706-6711 NNP denotes MgCl2
T2923 6711-6712 , denotes ,
T2924 6713-6716 CD denotes 0.5
T2925 6717-6719 NNP denotes mM
T2926 6720-6724 NNP denotes NaCl
T2927 6724-6725 , denotes ,
T2928 6726-6727 CD denotes 4
T2929 6727-6728 NN denotes %
T2930 6729-6737 NN denotes glycerol
T2931 6737-6738 , denotes ,
T2932 6739-6742 CD denotes 0.5
T2933 6743-6745 NNP denotes mM
T2934 6746-6750 NNP denotes EDTA
T2935 6750-6751 , denotes ,
T2936 6752-6755 CD denotes 0.5
T2937 6756-6758 NNP denotes mM
T2938 6759-6762 NNP denotes DTT
T2939 6762-6763 , denotes ,
T2940 6764-6767 CC denotes and
T2941 6768-6769 CD denotes 2
T2942 6770-6772 NN denotes μg
T2943 6773-6777 NN denotes poly
T2944 6778-6783 NN denotes dI-dC
T2945 6784-6787 IN denotes for
T2946 6788-6790 CD denotes 20
T2947 6791-6798 NNS denotes minutes
T2948 6799-6801 IN denotes on
T2949 6802-6805 NN denotes ice
T2950 6805-6806 . denotes .
T2951 6807-6812 IN denotes After
T2952 6813-6821 NN denotes addition
T2953 6822-6824 IN denotes of
T2954 6825-6828 DT denotes the
T2955 6829-6830 CD denotes 1
T2956 6831-6833 NNP denotes μL
T2957 6834-6844 JJ denotes 32P-labled
T2958 6845-6860 NN denotes oligonucleotide
T2959 6861-6866 NN denotes probe
T2960 6866-6867 , denotes ,
T2961 6868-6871 DT denotes the
T2962 6872-6882 NN denotes incubation
T2963 6883-6886 VBD denotes was
T2964 6887-6896 VBN denotes continued
T2965 6897-6900 IN denotes for
T2966 6901-6903 CD denotes 20
T2967 6904-6911 NNS denotes minutes
T2968 6912-6914 IN denotes on
T2969 6915-6918 NN denotes ice
T2970 6918-6919 . denotes .
T2971 6920-6923 DT denotes The
T2972 6924-6935 JJ denotes DNA-protein
T2973 6936-6945 NNS denotes complexes
T2974 6946-6950 VBD denotes were
T2975 6951-6960 VBN denotes separated
T2976 6961-6963 IN denotes by
T2977 6964-6979 NN denotes electrophoresis
T2978 6980-6982 IN denotes on
T2979 6983-6984 CD denotes 4
T2980 6984-6985 NN denotes %
T2981 6986-6999 JJ denotes nondenaturing
T2982 7000-7014 NN denotes polyacrylamide
T2983 7015-7018 NN denotes gel
T2984 7019-7021 IN denotes in
T2985 7022-7025 CD denotes 0.5
T2986 7026-7027 CD denotes ×
T2987 7028-7031 NNP denotes TBE
T2988 7032-7038 NN denotes buffer
T2989 7039-7040 -LRB- denotes (
T2990 7040-7056 NNP denotes tris-borate-EDTA
T2991 7056-7057 -RRB- denotes )
T2992 7058-7060 IN denotes at
T2993 7061-7064 CD denotes 390
T2994 7065-7066 NN denotes V
T2995 7067-7070 IN denotes for
T2996 7071-7072 CD denotes 1
T2997 7073-7077 NN denotes hour
T2998 7078-7080 IN denotes at
T2999 7081-7082 CD denotes 4
T3000 7082-7083 CD denotes °
T3001 7083-7084 NNP denotes C
T3002 7084-7085 . denotes .
T3003 7086-7091 IN denotes After
T3004 7092-7107 NN denotes electrophoresis
T3005 7107-7108 , denotes ,
T3006 7109-7112 DT denotes the
T3007 7113-7116 NN denotes gel
T3008 7117-7120 VBD denotes was
T3009 7121-7126 VBN denotes dried
T3010 7127-7130 CC denotes and
T3011 7131-7138 VBN denotes exposed
T3012 7139-7141 TO denotes to
T3013 7142-7147 NN denotes X-ray
T3014 7148-7152 NN denotes film
T3015 7153-7154 -LRB- denotes (
T3016 7154-7158 NNP denotes Fuji
T3017 7159-7168 NNP denotes Hyperfilm
T3018 7168-7169 , denotes ,
T3019 7170-7175 NNP denotes Tokyo
T3020 7175-7176 , denotes ,
T3021 7177-7182 NNP denotes Japan
T3022 7182-7183 -RRB- denotes )
T3023 7183-7184 . denotes .
T3024 7185-7191 NNS denotes Levels
T3025 7192-7194 IN denotes of
T3026 7195-7200 NNP denotes NF-κB
T3027 7201-7204 NNP denotes DNA
T3028 7205-7212 JJ denotes binding
T3029 7213-7221 NN denotes activity
T3030 7222-7226 VBD denotes were
T3031 7227-7237 VBN denotes quantified
T3032 7238-7240 IN denotes by
T3033 7241-7249 NN denotes software
T3034 7250-7256 NNP denotes ImageJ
T3035 7256-7257 . denotes .
T3233 7259-7262 CD denotes 2.5
T3234 7262-7263 . denotes .
T3235 7264-7270 NNP denotes RT-PCR
T3236 7271-7276 NNP denotes Total
T3237 7277-7280 NNP denotes RNA
T3238 7281-7284 VBD denotes was
T3239 7285-7293 VBN denotes isolated
T3240 7294-7298 IN denotes with
T3241 7299-7305 NNP denotes Trizol
T3242 7306-7307 -LRB- denotes (
T3243 7307-7317 NNP denotes Invitrogen
T3244 7317-7318 , denotes ,
T3245 7319-7321 NNP denotes CA
T3246 7321-7322 , denotes ,
T3247 7323-7326 NNP denotes USA
T3248 7326-7327 -RRB- denotes )
T3249 7327-7328 , denotes ,
T3250 7329-7332 CC denotes and
T3251 7333-7348 JJ denotes single-stranded
T3252 7349-7353 NNP denotes cDNA
T3253 7354-7357 VBD denotes was
T3254 7358-7369 VBN denotes synthesized
T3255 7370-7374 IN denotes from
T3256 7375-7376 CD denotes 2
T3257 7377-7379 NN denotes μg
T3258 7380-7382 IN denotes of
T3259 7383-7388 JJ denotes total
T3260 7389-7392 NNP denotes RNA
T3261 7393-7397 IN denotes with
T3262 7398-7407 JJ denotes BU-Script
T3263 7408-7414 NN denotes RT-Kit
T3264 7415-7416 -LRB- denotes (
T3265 7416-7424 NNP denotes Biunique
T3266 7424-7425 , denotes ,
T3267 7426-7433 NNP denotes Jiangsu
T3268 7433-7434 , denotes ,
T3269 7435-7440 NNP denotes China
T3270 7440-7441 -RRB- denotes )
T3271 7442-7451 VBG denotes according
T3272 7452-7454 TO denotes to
T3273 7455-7458 DT denotes the
T3274 7459-7471 NN denotes manufacturer
T3275 7471-7473 POS denotes 's
T3276 7474-7482 NN denotes protocol
T3277 7482-7483 . denotes .
T3278 7484-7487 DT denotes The
T3279 7488-7492 NNP denotes cDNA
T3280 7493-7496 VBD denotes was
T3281 7497-7503 VBN denotes stored
T3282 7504-7506 IN denotes in
T3283 7507-7508 CD denotes −
T3284 7508-7510 CD denotes 20
T3285 7510-7511 NN denotes °
T3286 7511-7513 NNP denotes C.
T3287 7514-7521 VB denotes Reverse
T3288 7522-7535 NN denotes transcription
T3289 7536-7539 VBD denotes was
T3290 7540-7549 VBN denotes conducted
T3291 7550-7554 IN denotes with
T3292 7555-7560 NNP denotes GoTaq
T3293 7561-7566 NNP denotes Green
T3294 7567-7573 NNP denotes Master
T3295 7574-7577 NNP denotes Mix
T3296 7578-7579 -LRB- denotes (
T3297 7579-7586 NNP denotes Promega
T3298 7586-7587 , denotes ,
T3299 7588-7590 NNP denotes WI
T3300 7590-7591 , denotes ,
T3301 7592-7595 NNP denotes USA
T3302 7595-7596 -RRB- denotes )
T3303 7597-7606 VBG denotes according
T3304 7607-7609 TO denotes to
T3305 7610-7613 DT denotes the
T3306 7614-7626 NN denotes manufacturer
T3307 7626-7628 POS denotes 's
T3308 7629-7637 NN denotes protocol
T3309 7637-7638 . denotes .
T3310 7640-7645 NNP denotes Table
T3311 7646-7647 CD denotes 1
T3312 7648-7653 VBZ denotes shows
T3313 7654-7657 DT denotes the
T3314 7658-7665 NNS denotes primers
T3315 7666-7669 CC denotes and
T3316 7670-7673 NNP denotes PCR
T3317 7674-7684 NNS denotes parameters
T3318 7684-7685 . denotes .
T3319 7686-7689 NNP denotes PCR
T3320 7690-7698 NNS denotes products
T3321 7699-7703 VBD denotes were
T3322 7704-7712 VBN denotes detected
T3323 7713-7715 IN denotes by
T3324 7716-7723 JJ denotes agarose
T3325 7724-7727 NN denotes gel
T3326 7728-7743 NN denotes electrophoresis
T3327 7743-7744 . denotes .
T3328 7745-7748 DT denotes The
T3329 7749-7758 NN denotes intensity
T3330 7759-7761 IN denotes of
T3331 7762-7765 DT denotes the
T3332 7766-7771 NNS denotes bands
T3333 7772-7775 VBD denotes was
T3334 7776-7784 VBN denotes analyzed
T3335 7785-7787 IN denotes by
T3336 7788-7794 NNP denotes ImageJ
T3337 7795-7802 NN denotes program
T3338 7802-7803 . denotes .
T3339 7804-7807 DT denotes The
T3340 7808-7813 NN denotes level
T3341 7814-7816 IN denotes of
T3342 7817-7824 NN denotes β-actin
T3343 7825-7828 VBD denotes was
T3344 7829-7833 VBN denotes used
T3345 7834-7836 IN denotes as
T3346 7837-7839 DT denotes an
T3347 7840-7848 JJ denotes internal
T3348 7849-7857 NN denotes standard
T3349 7857-7858 . denotes .
T3697 7860-7863 CD denotes 2.6
T3698 7863-7864 . denotes .
T3699 7865-7872 JJ denotes Western
T3700 7873-7877 NNP denotes Blot
T3701 7878-7880 TO denotes To
T3702 7881-7887 VB denotes obtain
T3703 7888-7893 JJ denotes total
T3704 7894-7901 NN denotes protein
T3705 7902-7909 VBZ denotes lysates
T3706 7909-7910 , denotes ,
T3707 7911-7916 NNS denotes cells
T3708 7917-7921 VBD denotes were
T3709 7922-7933 VBN denotes homogenized
T3710 7934-7936 IN denotes in
T3711 7937-7941 NNP denotes RIPA
T3712 7942-7948 NN denotes buffer
T3713 7949-7950 -LRB- denotes (
T3714 7950-7951 CD denotes 1
T3715 7951-7952 NN denotes %
T3716 7953-7957 CD denotes NP40
T3717 7957-7958 , denotes ,
T3718 7959-7962 CD denotes 0.5
T3719 7962-7963 NN denotes %
T3720 7964-7970 NN denotes sodium
T3721 7971-7983 NN denotes deoxycholate
T3722 7983-7984 , denotes ,
T3723 7985-7988 CD denotes 0.1
T3724 7988-7989 NN denotes %
T3725 7990-7993 NNP denotes SDS
T3726 7993-7994 , denotes ,
T3727 7995-7996 CD denotes 1
T3728 7997-7999 NNP denotes mM
T3729 8000-8004 NNP denotes EDTA
T3730 8004-8005 , denotes ,
T3731 8006-8007 CD denotes 1
T3732 8008-8010 NNP denotes mM
T3733 8011-8015 NNP denotes EGTA
T3734 8015-8016 , denotes ,
T3735 8017-8018 CD denotes 1
T3736 8019-8021 NNP denotes mM
T3737 8022-8028 NNP denotes Na3VO4
T3738 8028-8029 , denotes ,
T3739 8030-8032 CD denotes 20
T3740 8033-8035 NNP denotes mM
T3741 8036-8039 NNP denotes NaF
T3742 8039-8040 , denotes ,
T3743 8041-8044 CD denotes 0.5
T3744 8045-8047 NNP denotes mM
T3745 8048-8051 NNP denotes DTT
T3746 8051-8052 , denotes ,
T3747 8053-8054 CD denotes 1
T3748 8055-8057 NNP denotes mM
T3749 8058-8062 NNP denotes PMSF
T3750 8062-8063 , denotes ,
T3751 8064-8067 CC denotes and
T3752 8068-8076 NN denotes protease
T3753 8077-8086 NN denotes inhibitor
T3754 8087-8095 NN denotes cocktail
T3755 8096-8098 IN denotes in
T3756 8099-8102 NNP denotes PBS
T3757 8103-8105 NNP denotes pH
T3758 8106-8109 CD denotes 7.4
T3759 8109-8110 -RRB- denotes )
T3760 8111-8114 CC denotes and
T3761 8115-8126 VBN denotes centrifuged
T3762 8127-8129 IN denotes at
T3763 8130-8136 CD denotes 12,000
T3764 8137-8138 NN denotes g
T3765 8139-8142 IN denotes for
T3766 8143-8145 CD denotes 15
T3767 8146-8149 NN denotes min
T3768 8150-8152 IN denotes at
T3769 8153-8154 CD denotes 4
T3770 8154-8155 CD denotes °
T3771 8155-8157 NNP denotes C.
T3772 8158-8165 NNP denotes Protein
T3773 8166-8180 NNS denotes concentrations
T3774 8181-8185 VBD denotes were
T3775 8186-8195 VBN denotes estimated
T3776 8196-8198 IN denotes by
T3777 8199-8208 NNP denotes Coomassie
T3778 8209-8213 NNP denotes Plus
T3779 8214-8221 NNP denotes Protein
T3780 8222-8227 NNP denotes Assay
T3781 8228-8235 NNP denotes Reagent
T3782 8236-8237 -LRB- denotes (
T3783 8237-8243 NNP denotes Pierce
T3784 8243-8244 , denotes ,
T3785 8245-8247 NNP denotes IL
T3786 8247-8248 , denotes ,
T3787 8249-8252 NNP denotes USA
T3788 8252-8253 -RRB- denotes )
T3789 8253-8254 . denotes .
T3790 8255-8260 NNP denotes Fifty
T3791 8261-8271 NNS denotes micrograms
T3792 8272-8274 IN denotes of
T3793 8275-8278 DT denotes the
T3794 8279-8288 VBG denotes resulting
T3795 8289-8298 JJ denotes cytosolic
T3796 8299-8306 NN denotes protein
T3797 8307-8315 NNS denotes extracts
T3798 8316-8320 VBD denotes were
T3799 8321-8335 JJ denotes heat-denatured
T3800 8336-8338 IN denotes in
T3801 8339-8346 NNP denotes Laemmli
T3802 8347-8353 NN denotes sample
T3803 8354-8361 VBG denotes loading
T3804 8362-8368 NN denotes buffer
T3805 8368-8369 , denotes ,
T3806 8370-8379 VBN denotes separated
T3807 8380-8382 IN denotes by
T3808 8383-8385 CD denotes 10
T3809 8385-8386 NN denotes %
T3810 8387-8393 NN denotes sodium
T3811 8394-8401 NN denotes dodecyl
T3812 8402-8409 NN denotes sulfate
T3813 8410-8424 NN denotes polyacrylamide
T3814 8425-8428 NN denotes gel
T3815 8429-8444 NN denotes electrophoresis
T3816 8444-8445 , denotes ,
T3817 8446-8449 CC denotes and
T3818 8450-8464 VBD denotes electroblotted
T3819 8465-8469 IN denotes onto
T3820 8470-8471 DT denotes a
T3821 8472-8486 JJ denotes nitrocellulose
T3822 8487-8495 NN denotes membrane
T3823 8495-8496 . denotes .
T3824 8497-8500 IN denotes For
T3825 8501-8515 VBG denotes immunoblotting
T3826 8515-8516 , denotes ,
T3827 8517-8526 NNS denotes membranes
T3828 8527-8531 VBD denotes were
T3829 8532-8539 VBN denotes blocked
T3830 8540-8544 IN denotes with
T3831 8545-8546 CD denotes 5
T3832 8546-8547 NN denotes %
T3833 8548-8554 JJ denotes nonfat
T3834 8555-8558 JJ denotes dry
T3835 8559-8563 NN denotes milk
T3836 8564-8566 IN denotes in
T3837 8567-8573 NN denotes saline
T3838 8574-8580 NN denotes buffer
T3839 8581-8590 JJ denotes overnight
T3840 8591-8593 IN denotes at
T3841 8594-8595 CD denotes 4
T3842 8595-8596 CD denotes °
T3843 8596-8597 NNP denotes C
T3844 8597-8598 , denotes ,
T3845 8599-8602 CC denotes and
T3846 8603-8606 DT denotes the
T3847 8607-8616 VBG denotes following
T3848 8617-8627 NNS denotes antibodies
T3849 8628-8632 VBD denotes were
T3850 8633-8637 VBN denotes used
T3851 8637-8638 : denotes :
T3852 8639-8651 JJ denotes anti-β-actin
T3853 8652-8653 -LRB- denotes (
T3854 8653-8662 JJ denotes sc-130657
T3855 8662-8663 , denotes ,
T3856 8664-8669 NNP denotes Santa
T3857 8670-8674 NNP denotes Cruz
T3858 8675-8688 NNP denotes Biotechnology
T3859 8688-8689 , denotes ,
T3860 8690-8692 NNP denotes CA
T3861 8692-8693 , denotes ,
T3862 8694-8697 NNP denotes USA
T3863 8697-8698 , denotes ,
T3864 8699-8701 CD denotes 43
T3865 8702-8705 NN denotes kDa
T3866 8705-8706 -RRB- denotes )
T3867 8707-8710 CC denotes and
T3868 8711-8722 JJ denotes anti-matrix
T3869 8723-8739 NN denotes metallopeptidase
T3870 8740-8741 CD denotes 9
T3871 8742-8743 -LRB- denotes (
T3872 8743-8747 NNP denotes MMP9
T3873 8747-8748 -RRB- denotes )
T3874 8749-8750 -LRB- denotes (
T3875 8750-8757 JJ denotes sc-6841
T3876 8757-8758 , denotes ,
T3877 8759-8764 NNP denotes Santa
T3878 8765-8769 NNP denotes Cruz
T3879 8770-8783 NNP denotes Biotechnology
T3880 8783-8784 , denotes ,
T3881 8785-8787 NNP denotes CA
T3882 8787-8788 , denotes ,
T3883 8789-8792 NNP denotes USA
T3884 8792-8793 , denotes ,
T3885 8794-8796 CD denotes 92
T3886 8797-8800 NN denotes kDa
T3887 8800-8801 -RRB- denotes )
T3888 8801-8802 . denotes .
T3889 8803-8807 DT denotes Each
T3890 8808-8815 JJ denotes primary
T3891 8816-8824 NN denotes antibody
T3892 8825-8828 VBD denotes was
T3893 8829-8836 VBN denotes diluted
T3894 8837-8850 RB denotes appropriately
T3895 8851-8853 IN denotes in
T3896 8854-8862 VBG denotes blocking
T3897 8863-8869 NN denotes buffer
T3898 8870-8873 CC denotes and
T3899 8874-8878 RB denotes then
T3900 8879-8884 VBD denotes added
T3901 8885-8887 TO denotes to
T3902 8888-8891 DT denotes the
T3903 8892-8897 NNS denotes blots
T3904 8898-8901 IN denotes for
T3905 8902-8903 CD denotes 1
T3906 8904-8905 NN denotes h
T3907 8906-8908 IN denotes at
T3908 8909-8913 NN denotes room
T3909 8914-8925 NN denotes temperature
T3910 8925-8926 . denotes .
T3911 8927-8930 DT denotes The
T3912 8931-8936 NNS denotes blots
T3913 8937-8941 VBD denotes were
T3914 8942-8948 VBN denotes washed
T3915 8949-8954 CD denotes three
T3916 8955-8960 NNS denotes times
T3917 8961-8963 IN denotes in
T3918 8964-8967 DT denotes the
T3919 8968-8975 VBG denotes washing
T3920 8976-8982 NN denotes buffer
T3921 8983-8986 CC denotes and
T3922 8987-8994 VBN denotes covered
T3923 8995-8999 IN denotes with
T3924 9000-9003 DT denotes the
T3925 9004-9015 JJ denotes horseradish
T3926 9016-9033 JJ denotes peroxidase-linked
T3927 9034-9043 JJ denotes secondary
T3928 9044-9052 NN denotes antibody
T3929 9053-9055 IN denotes at
T3930 9056-9057 DT denotes a
T3931 9058-9059 CD denotes 1
T3932 9060-9061 : denotes :
T3933 9062-9066 CD denotes 2000
T3934 9067-9075 NN denotes dilution
T3935 9076-9079 IN denotes for
T3936 9080-9081 CD denotes 1
T3937 9082-9084 NN denotes h.
T3938 9085-9090 NNS denotes Blots
T3939 9091-9095 VBD denotes were
T3940 9096-9105 VBN denotes incubated
T3941 9106-9110 IN denotes with
T3942 9111-9119 JJ denotes enhanced
T3943 9120-9137 NN denotes chemiluminescence
T3944 9138-9139 -LRB- denotes (
T3945 9139-9142 NNP denotes ECL
T3946 9142-9143 -RRB- denotes )
T3947 9144-9153 NN denotes detection
T3948 9154-9160 NN denotes system
T3949 9161-9162 -LRB- denotes (
T3950 9162-9170 NNP denotes Amersham
T3951 9171-9182 NNP denotes Biosciences
T3952 9182-9183 , denotes ,
T3953 9184-9189 NNP denotes Bucks
T3954 9189-9190 , denotes ,
T3955 9191-9193 NNP denotes UK
T3956 9193-9194 -RRB- denotes )
T3957 9195-9198 CC denotes and
T3958 9199-9206 VBN denotes exposed
T3959 9207-9209 TO denotes to
T3960 9210-9222 JJ denotes radiographic
T3961 9223-9227 NN denotes film
T3962 9228-9229 -LRB- denotes (
T3963 9229-9233 NNP denotes Fuji
T3964 9234-9243 NNP denotes Hyperfilm
T3965 9243-9244 , denotes ,
T3966 9245-9250 NNP denotes Tokyo
T3967 9250-9251 , denotes ,
T3968 9252-9257 NNP denotes Japan
T3969 9257-9258 -RRB- denotes )
T3970 9258-9259 . denotes .
T3971 9260-9266 NNP denotes ImageJ
T3972 9267-9270 VBD denotes was
T3973 9271-9275 VBN denotes used
T3974 9276-9278 TO denotes to
T3975 9279-9286 VB denotes analyze
T3976 9287-9290 DT denotes the
T3977 9291-9300 NN denotes intensity
T3978 9301-9303 IN denotes of
T3979 9304-9307 DT denotes the
T3980 9308-9313 NNS denotes blots
T3981 9313-9314 . denotes .
T3982 9315-9318 DT denotes The
T3983 9319-9324 NN denotes level
T3984 9325-9327 IN denotes of
T3985 9328-9335 NN denotes β-actin
T3986 9336-9339 VBD denotes was
T3987 9340-9344 VBN denotes used
T3988 9345-9347 IN denotes as
T3989 9348-9356 JJ denotes internal
T3990 9357-9365 NN denotes standard
T3991 9365-9366 . denotes .
T4560 10541-10544 CD denotes 2.8
T4561 10544-10545 . denotes .
T4562 10546-10554 NNP denotes Gelatine
T4563 10555-10565 NNP denotes Zymography
T4564 10566-10571 NNP denotes Cells
T4565 10572-10574 IN denotes of
T4566 10575-10579 CD denotes four
T4567 10580-10586 NNS denotes groups
T4568 10587-10591 VBD denotes were
T4569 10592-10603 VBN denotes homogenized
T4570 10604-10606 IN denotes in
T4571 10607-10612 NN denotes lysis
T4572 10613-10619 NN denotes buffer
T4573 10620-10630 VBG denotes containing
T4574 10631-10633 CD denotes 50
T4575 10634-10636 NNP denotes mM
T4576 10637-10645 NNP denotes Tris-HCl
T4577 10646-10647 -LRB- denotes (
T4578 10647-10649 NNP denotes pH
T4579 10650-10653 CD denotes 7.4
T4580 10653-10654 -RRB- denotes )
T4581 10654-10655 , denotes ,
T4582 10656-10659 CD denotes 150
T4583 10660-10662 NNP denotes mM
T4584 10663-10667 NNP denotes NaCl
T4585 10667-10668 , denotes ,
T4586 10669-10670 CD denotes 5
T4587 10671-10673 NNP denotes mM
T4588 10674-10679 NNP denotes CaCl2
T4589 10679-10680 , denotes ,
T4590 10681-10684 CD denotes 0.2
T4591 10685-10687 NNP denotes mM
T4592 10688-10692 NNP denotes NaN3
T4593 10692-10693 , denotes ,
T4594 10694-10697 CC denotes and
T4595 10698-10702 CD denotes 0.01
T4596 10702-10703 NN denotes %
T4597 10704-10710 NNP denotes Triton
T4598 10710-10711 . denotes .
T4599 10712-10719 JJ denotes Soluble
T4600 10720-10728 NNS denotes extracts
T4601 10729-10733 VBD denotes were
T4602 10734-10743 VBN denotes separated
T4603 10744-10746 IN denotes by
T4604 10747-10761 NN denotes centrifugation
T4605 10762-10765 CC denotes and
T4606 10766-10772 VBD denotes stored
T4607 10773-10775 IN denotes at
T4608 10777-10779 CD denotes 20
T4609 10779-10780 NN denotes °
T4610 10780-10782 NNP denotes C.
T4611 10783-10790 NNP denotes Gelatin
T4612 10791-10801 NN denotes zymography
T4613 10802-10805 VBD denotes was
T4614 10806-10815 VBN denotes performed
T4615 10816-10825 VBG denotes according
T4616 10826-10828 TO denotes to
T4617 10829-10832 DT denotes the
T4618 10833-10845 NN denotes manufacturer
T4619 10845-10847 POS denotes 's
T4620 10848-10860 NNS denotes instructions
T4621 10861-10862 -LRB- denotes (
T4622 10862-10868 NNP denotes Genmed
T4623 10869-10880 NNP denotes Scientifics
T4624 10881-10884 NNP denotes Inc
T4625 10884-10885 , denotes ,
T4626 10886-10888 NNP denotes MA
T4627 10888-10889 , denotes ,
T4628 10890-10893 NNP denotes USA
T4629 10893-10894 -RRB- denotes )
T4630 10894-10895 . denotes .
T4631 10896-10903 RB denotes Briefly
T4632 10903-10904 , denotes ,
T4633 10905-10907 CD denotes 40
T4634 10908-10910 NN denotes μg
T4635 10911-10920 JJ denotes cytosolic
T4636 10921-10928 NN denotes protein
T4637 10929-10937 NNS denotes extracts
T4638 10938-10942 VBD denotes were
T4639 10943-10952 VBN denotes separated
T4640 10953-10955 IN denotes by
T4641 10956-10971 NN denotes electrophoresis
T4642 10971-10972 . denotes .
T4643 10973-10977 RB denotes Then
T4644 10978-10981 DT denotes the
T4645 10982-10990 NNS denotes proteins
T4646 10991-10995 VBD denotes were
T4647 10996-11005 VBN denotes renatured
T4648 11006-11008 IN denotes by
T4649 11009-11019 NN denotes incubation
T4650 11020-11022 IN denotes in
T4651 11023-11026 CD denotes 2.5
T4652 11026-11027 NN denotes %
T4653 11028-11034 NNP denotes Triton
T4654 11035-11040 NNP denotes X-100
T4655 11041-11044 CC denotes and
T4656 11045-11049 RB denotes then
T4657 11050-11059 VBD denotes incubated
T4658 11060-11062 IN denotes in
T4659 11063-11072 JJ denotes substrate
T4660 11073-11079 NN denotes buffer
T4661 11080-11083 IN denotes for
T4662 11084-11086 CD denotes 40
T4663 11087-11088 NN denotes h
T4664 11089-11091 IN denotes at
T4665 11092-11094 CD denotes 37
T4666 11094-11095 CD denotes °
T4667 11095-11096 NNP denotes C
T4668 11097-11099 TO denotes to
T4669 11100-11106 VB denotes enable
T4670 11107-11110 DT denotes the
T4671 11111-11115 NNP denotes MMP9
T4672 11116-11118 TO denotes to
T4673 11119-11125 VB denotes cleave
T4674 11126-11129 DT denotes the
T4675 11130-11137 NN denotes gelatin
T4676 11137-11138 . denotes .
T4677 11139-11144 IN denotes After
T4678 11145-11152 VBG denotes rinsing
T4679 11153-11155 IN denotes in
T4680 11156-11161 NN denotes water
T4681 11161-11162 , denotes ,
T4682 11163-11167 DT denotes each
T4683 11168-11171 NN denotes gel
T4684 11172-11175 VBD denotes was
T4685 11176-11183 VBN denotes stained
T4686 11184-11188 IN denotes with
T4687 11189-11198 NNP denotes Coomassie
T4688 11199-11203 JJ denotes blue
T4689 11204-11207 IN denotes for
T4690 11208-11209 CD denotes 1
T4691 11210-11211 NN denotes h
T4692 11212-11215 CC denotes and
T4693 11216-11225 VBN denotes destained
T4694 11226-11228 IN denotes in
T4695 11229-11231 CD denotes 50
T4696 11231-11232 NN denotes %
T4697 11233-11241 NN denotes methanol
T4698 11241-11242 . denotes .
T4699 11243-11254 JJ denotes Proteolytic
T4700 11255-11265 NNS denotes activities
T4701 11266-11270 VBD denotes were
T4702 11271-11277 VBN denotes showed
T4703 11278-11280 IN denotes by
T4704 11281-11286 JJ denotes clear
T4705 11287-11292 NNS denotes bands
T4706 11293-11295 IN denotes in
T4707 11296-11300 JJ denotes blue
T4708 11301-11304 NN denotes gel
T4709 11305-11310 WDT denotes which
T4710 11311-11320 VBZ denotes indicates
T4711 11321-11324 DT denotes the
T4712 11325-11330 NN denotes lysis
T4713 11331-11333 IN denotes of
T4714 11334-11337 DT denotes the
T4715 11338-11347 NN denotes substrate
T4716 11347-11348 . denotes .
T4717 11349-11363 NN denotes Quantification
T4718 11364-11366 IN denotes of
T4719 11367-11371 NNP denotes MMP9
T4720 11372-11376 NN denotes band
T4721 11377-11384 NN denotes density
T4722 11385-11388 VBD denotes was
T4723 11389-11398 VBN denotes performed
T4724 11399-11403 IN denotes with
T4725 11404-11409 NN denotes image
T4726 11410-11418 NN denotes analysis
T4727 11419-11426 NN denotes program
T4728 11427-11433 NNP denotes ImageJ
T4729 11433-11434 . denotes .
T4799 11436-11439 CD denotes 2.9
T4800 11439-11440 . denotes .
T4801 11441-11452 NNP denotes Statistical
T4802 11453-11461 NNP denotes Analysis
T4803 11462-11466 NNP denotes Data
T4804 11467-11471 VBD denotes were
T4805 11472-11481 VBN denotes expressed
T4806 11482-11484 IN denotes as
T4807 11485-11489 JJ denotes mean
T4808 11490-11491 NN denotes ±
T4809 11492-11494 NNP denotes SD
T4810 11495-11498 CC denotes and
T4811 11499-11508 VBN denotes evaluated
T4812 11509-11511 IN denotes by
T4813 11512-11517 NNP denotes ANOVA
T4814 11518-11521 CC denotes and
T4815 11522-11525 NNP denotes LSD
T4816 11526-11534 JJ denotes multiple
T4817 11535-11545 NN denotes comparison
T4818 11546-11550 NN denotes test
T4819 11550-11551 . denotes .
T4820 11552-11553 NN denotes P
T4821 11554-11560 NNS denotes values
T4822 11561-11562 VBP denotes <
T4823 11562-11566 CD denotes 0.05
T4824 11567-11571 VBD denotes were
T4825 11572-11582 VBN denotes considered
T4826 11583-11585 TO denotes to
T4827 11586-11588 VB denotes be
T4828 11589-11600 JJ denotes significant
T4829 11600-11601 . denotes .
T4830 11602-11605 DT denotes All
T4831 11606-11614 NNS denotes analyses
T4832 11615-11619 VBD denotes were
T4833 11620-11629 VBN denotes performed
T4834 11630-11632 IN denotes by
T4835 11633-11638 VBG denotes using
T4836 11639-11643 NNP denotes SPSS
T4837 11644-11648 CD denotes 18.0
T4838 11649-11657 NN denotes software
T4839 11657-11658 . denotes .
T4973 11672-11675 CD denotes 3.1
T4974 11675-11676 . denotes .
T4975 11677-11686 NN denotes Depletion
T4976 11687-11689 IN denotes of
T4977 11690-11694 NNP denotes Nrf2
T4978 11695-11705 NNP denotes Aggravated
T4979 11706-11709 DT denotes the
T4980 11710-11714 NNP denotes Cell
T4981 11715-11720 NNP denotes Death
T4982 11721-11723 IN denotes in
T4983 11724-11734 NNP denotes Astrocytes
T4984 11735-11740 IN denotes after
T4985 11741-11748 NNP denotes Scratch
T4986 11749-11755 NNP denotes Injury
T4987 11756-11760 NNP denotes Cell
T4988 11761-11766 NN denotes death
T4989 11767-11770 VBD denotes was
T4990 11771-11779 VBN denotes detected
T4991 11780-11782 IN denotes by
T4992 11783-11793 NN denotes microscope
T4993 11794-11797 CC denotes and
T4994 11798-11803 NN denotes CCK-8
T4995 11804-11812 NN denotes analysis
T4996 11813-11815 IN denotes at
T4997 11816-11818 CD denotes 24
T4998 11819-11820 NN denotes h
T4999 11821-11826 IN denotes after
T5000 11827-11834 NN denotes scratch
T5001 11834-11835 . denotes .
T5002 11836-11839 DT denotes The
T5003 11840-11850 NN denotes detachment
T5004 11851-11855 IN denotes from
T5005 11856-11863 NN denotes culture
T5006 11864-11869 NN denotes plate
T5007 11869-11870 , denotes ,
T5008 11871-11875 NN denotes cell
T5009 11876-11880 VBD denotes lost
T5010 11880-11881 , denotes ,
T5011 11882-11885 CC denotes and
T5012 11886-11897 JJ denotes cytoplasmic
T5013 11898-11905 NN denotes process
T5014 11906-11916 NN denotes distortion
T5015 11917-11921 VBD denotes were
T5016 11922-11928 RB denotes mostly
T5017 11929-11937 VBN denotes observed
T5018 11938-11940 IN denotes in
T5019 11941-11945 DT denotes both
T5020 11946-11951 NNS denotes sides
T5021 11952-11954 IN denotes of
T5022 11955-11962 NN denotes scratch
T5023 11963-11967 NN denotes line
T5024 11968-11970 IN denotes in
T5025 11971-11976 NN denotes group
T5026 11977-11979 NNP denotes KO
T5027 11980-11983 NNP denotes TBI
T5028 11983-11984 . denotes .
T5029 11985-11990 CD denotes CCK-8
T5030 11991-11996 NN denotes assay
T5031 11997-12001 RB denotes also
T5032 12002-12008 VBD denotes showed
T5033 12009-12014 JJR denotes lower
T5034 12015-12017 NNP denotes OD
T5035 12018-12023 NN denotes value
T5036 12024-12026 IN denotes of
T5037 12027-12032 NN denotes group
T5038 12033-12035 NNP denotes KO
T5039 12036-12039 NNP denotes TBI
T5040 12040-12041 -LRB- denotes (
T5041 12041-12045 CD denotes 0.38
T5042 12046-12047 CD denotes ±
T5043 12048-12053 CD denotes 0.064
T5044 12053-12054 -RRB- denotes )
T5045 12055-12059 IN denotes than
T5046 12060-12064 DT denotes that
T5047 12065-12067 IN denotes of
T5048 12068-12073 NN denotes group
T5049 12074-12076 NNP denotes WT
T5050 12077-12080 NNP denotes TBI
T5051 12081-12082 -LRB- denotes (
T5052 12082-12086 CD denotes 0.98
T5053 12087-12088 CD denotes ±
T5054 12089-12094 CD denotes 0.098
T5055 12094-12095 -RRB- denotes )
T5056 12096-12097 -LRB- denotes (
T5057 12097-12098 NNP denotes P
T5058 12099-12100 CD denotes <
T5059 12101-12105 CD denotes 0.01
T5060 12105-12106 -RRB- denotes )
T5061 12106-12107 , denotes ,
T5062 12108-12113 WDT denotes which
T5065 12114-12118 RB denotes also
T5066 12119-12128 VBD denotes suggested
T5067 12129-12133 JJR denotes more
T5068 12134-12138 NN denotes cell
T5069 12139-12144 NN denotes death
T5070 12145-12147 IN denotes in
T5071 12148-12153 NN denotes group
T5072 12154-12156 NNP denotes KO
T5073 12157-12160 NNP denotes TBI
T5074 12161-12162 -LRB- denotes (
T5075 12162-12168 NNP denotes Figure
T5076 12169-12170 CD denotes 1
T5077 12170-12171 -RRB- denotes )
T5078 12171-12172 . denotes .
T5079 12173-12178 EX denotes There
T5080 12179-12182 VBD denotes was
T5081 12183-12185 DT denotes no
T5082 12186-12196 NN denotes difference
T5083 12197-12204 IN denotes between
T5084 12205-12208 CD denotes two
T5085 12209-12222 JJ denotes sham-operated
T5086 12223-12229 NNS denotes groups
T5087 12229-12230 . denotes .
T5227 12232-12235 CD denotes 3.2
T5228 12235-12236 . denotes .
T5229 12237-12247 NN denotes Disruption
T5230 12248-12250 IN denotes of
T5231 12251-12255 NNP denotes Nrf2
T5232 12256-12264 NNP denotes Enhanced
T5233 12265-12277 NNP denotes Upregulation
T5234 12278-12280 IN denotes of
T5235 12281-12286 NNP denotes NF-κB
T5236 12287-12298 NNP denotes DNA-Binding
T5237 12299-12307 NN denotes Activity
T5238 12308-12313 IN denotes after
T5239 12314-12321 NNP denotes Scratch
T5240 12322-12328 NNP denotes Injury
T5241 12329-12331 PRP denotes It
T5242 12332-12335 VBZ denotes has
T5243 12336-12340 VBN denotes been
T5244 12341-12349 VBN denotes reported
T5245 12350-12354 IN denotes that
T5246 12355-12360 NNP denotes NF-κB
T5247 12361-12363 VBZ denotes is
T5248 12364-12373 VBN denotes activated
T5249 12374-12376 IN denotes in
T5250 12377-12382 NN denotes brain
T5251 12383-12388 IN denotes after
T5252 12389-12392 NNP denotes TBI
T5253 12393-12394 NNP denotes [
T5254 12394-12395 CD denotes 2
T5255 12395-12396 NNP denotes ]
T5256 12396-12397 . denotes .
T5257 12398-12402 RB denotes Here
T5258 12402-12403 , denotes ,
T5259 12404-12406 PRP denotes we
T5260 12407-12414 VBD denotes studied
T5261 12415-12418 DT denotes the
T5262 12419-12430 JJ denotes DNA-binding
T5263 12431-12439 NN denotes activity
T5264 12440-12442 IN denotes of
T5265 12443-12448 NN denotes NF-κB
T5266 12449-12451 IN denotes of
T5267 12452-12462 NNS denotes astrocytes
T5268 12463-12467 IN denotes from
T5269 12468-12472 NNP denotes Nrf2
T5270 12473-12475 NNP denotes WT
T5271 12476-12478 CC denotes or
T5272 12479-12481 NNP denotes KO
T5273 12482-12486 NNS denotes mice
T5274 12487-12489 IN denotes by
T5275 12490-12494 NNP denotes EMSA
T5276 12495-12497 IN denotes at
T5277 12498-12500 CD denotes 24
T5278 12501-12502 NN denotes h
T5279 12503-12508 IN denotes after
T5280 12509-12516 NN denotes scratch
T5281 12517-12523 NN denotes injury
T5282 12523-12524 . denotes .
T5283 12525-12532 NN denotes Scratch
T5284 12533-12539 NN denotes injury
T5285 12540-12547 VBD denotes induced
T5286 12548-12558 NN denotes activation
T5287 12559-12561 IN denotes of
T5288 12562-12567 NN denotes NF-κB
T5289 12568-12570 IN denotes in
T5290 12571-12581 NNS denotes astrocytes
T5291 12582-12584 IN denotes of
T5292 12585-12589 DT denotes both
T5293 12590-12599 NNS denotes genotypes
T5294 12599-12600 , denotes ,
T5295 12601-12606 IN denotes while
T5296 12607-12613 JJR denotes higher
T5297 12614-12619 NN denotes NF-κB
T5298 12620-12628 NN denotes activity
T5299 12629-12632 VBD denotes was
T5300 12633-12641 VBN denotes observed
T5301 12642-12644 IN denotes in
T5302 12645-12650 NN denotes group
T5303 12651-12653 NNP denotes KO
T5304 12654-12657 NNP denotes TBI
T5305 12658-12662 IN denotes than
T5306 12663-12665 IN denotes in
T5307 12666-12671 NN denotes group
T5308 12672-12674 NNP denotes WT
T5309 12675-12678 NNP denotes TBI
T5310 12679-12680 -LRB- denotes (
T5311 12680-12684 CD denotes 2.67
T5312 12685-12686 CD denotes ±
T5313 12687-12692 CD denotes 0.173
T5314 12693-12699 IN denotes versus
T5315 12700-12704 CD denotes 2.28
T5316 12705-12706 CD denotes ±
T5317 12707-12712 CD denotes 0.072
T5318 12712-12713 , denotes ,
T5319 12714-12715 NNP denotes P
T5320 12716-12717 VBD denotes <
T5321 12718-12722 CD denotes 0.01
T5322 12722-12723 -RRB- denotes )
T5323 12724-12725 -LRB- denotes (
T5324 12725-12731 NN denotes Figure
T5325 12732-12733 CD denotes 2
T5326 12733-12734 -RRB- denotes )
T5327 12734-12735 . denotes .
T5946 12737-12740 CD denotes 3.3
T5947 12740-12741 . denotes .
T5948 12742-12752 NN denotes Expression
T5949 12753-12755 IN denotes of
T5950 12756-12771 NNP denotes Proinflammatory
T5951 12772-12781 NNP denotes Cytokines
T5952 12782-12785 VBD denotes Was
T5953 12786-12794 NNP denotes Elevated
T5954 12795-12797 IN denotes in
T5955 12798-12802 NNP denotes Nrf2
T5956 12803-12811 NNP denotes Knockout
T5957 12812-12822 NNP denotes Astrocytes
T5958 12823-12828 IN denotes after
T5959 12829-12836 NNP denotes Scratch
T5960 12837-12843 NNP denotes Injury
T5961 12844-12846 IN denotes As
T5962 12847-12849 PRP denotes we
T5963 12850-12853 DT denotes all
T5964 12854-12858 VBP denotes know
T5965 12858-12859 , denotes ,
T5966 12860-12865 NNP denotes TNF-α
T5967 12865-12866 , denotes ,
T5968 12867-12872 NNP denotes IL-1β
T5969 12872-12873 , denotes ,
T5970 12874-12877 CC denotes and
T5971 12878-12882 NNP denotes IL-6
T5972 12883-12886 VBP denotes are
T5973 12887-12896 VBN denotes regulated
T5974 12897-12899 IN denotes by
T5975 12900-12905 NNP denotes NF-κB
T5976 12906-12909 CC denotes and
T5977 12910-12917 VBP denotes reflect
T5978 12918-12921 DT denotes the
T5979 12922-12932 JJ denotes endogenous
T5980 12933-12941 NN denotes activity
T5981 12942-12944 IN denotes of
T5982 12945-12950 NN denotes NF-κB
T5983 12950-12951 . denotes .
T5984 12952-12954 PRP denotes It
T5985 12955-12958 VBZ denotes has
T5986 12959-12963 VBN denotes been
T5987 12964-12972 VBN denotes revealed
T5988 12973-12977 IN denotes that
T5989 12978-12983 DT denotes these
T5990 12984-12999 JJ denotes proinflammatory
T5991 13000-13009 NNS denotes cytokines
T5992 13010-13013 VBP denotes are
T5993 13014-13023 VBN denotes increased
T5994 13024-13029 IN denotes after
T5995 13030-13033 NNP denotes TBI
T5996 13034-13036 IN denotes in
T5997 13037-13044 NNS denotes animals
T5998 13045-13046 VBP denotes [
T5999 13046-13047 CD denotes 2
T6000 13047-13048 , denotes ,
T6001 13049-13050 CD denotes 8
T6002 13050-13051 NN denotes ]
T6003 13051-13052 . denotes .
T6004 13053-13056 CC denotes And
T6005 13057-13060 PRP$ denotes our
T6006 13061-13069 JJ denotes previous
T6007 13070-13075 NN denotes study
T6008 13076-13079 VBZ denotes has
T6009 13080-13086 VBN denotes proved
T6010 13087-13091 IN denotes that
T6011 13092-13098 JJR denotes higher
T6012 13099-13105 NNS denotes levels
T6013 13106-13108 IN denotes of
T6014 13109-13113 JJ denotes such
T6015 13114-13129 JJ denotes proinflammatory
T6016 13130-13139 NNS denotes cytokines
T6017 13140-13144 VBD denotes were
T6018 13145-13153 VBN denotes observed
T6019 13154-13156 IN denotes in
T6020 13157-13160 DT denotes the
T6021 13161-13166 NN denotes brain
T6022 13167-13169 IN denotes of
T6023 13170-13184 JJ denotes Nrf2-deficient
T6024 13185-13189 NNS denotes mice
T6025 13190-13195 IN denotes after
T6026 13196-13199 NNP denotes TBI
T6027 13200-13201 NNP denotes [
T6028 13201-13202 CD denotes 5
T6029 13202-13203 NNP denotes ]
T6030 13203-13204 . denotes .
T6031 13205-13208 CC denotes But
T6032 13209-13211 PRP denotes it
T6033 13212-13214 VBZ denotes is
T6034 13215-13220 RB denotes still
T6035 13221-13230 JJ denotes ambiguous
T6036 13231-13236 IN denotes about
T6037 13237-13240 DT denotes the
T6038 13241-13253 NN denotes relationship
T6039 13254-13261 IN denotes between
T6040 13262-13267 DT denotes these
T6041 13268-13277 NNS denotes cytokines
T6042 13278-13281 CC denotes and
T6043 13282-13286 NNS denotes Nrf2
T6044 13287-13289 IN denotes in
T6045 13290-13300 NNS denotes astrocytes
T6046 13301-13306 IN denotes after
T6047 13307-13310 NNP denotes TBI
T6048 13310-13311 . denotes .
T6049 13312-13316 RB denotes Here
T6050 13316-13317 , denotes ,
T6051 13318-13320 PRP denotes we
T6052 13321-13327 VBD denotes tested
T6053 13328-13331 DT denotes the
T6054 13332-13338 NNS denotes levels
T6055 13339-13341 IN denotes of
T6056 13342-13347 NNP denotes TNF-α
T6057 13347-13348 , denotes ,
T6058 13349-13354 NNP denotes IL-1β
T6059 13354-13355 , denotes ,
T6060 13356-13359 CC denotes and
T6061 13360-13364 NNP denotes IL-6
T6062 13365-13367 IN denotes in
T6063 13368-13376 JJ denotes cultured
T6064 13377-13387 NNS denotes astrocytes
T6065 13388-13390 IN denotes at
T6066 13391-13393 CD denotes 24
T6067 13394-13395 NN denotes h
T6068 13396-13401 IN denotes after
T6069 13402-13409 NN denotes scratch
T6070 13410-13416 NN denotes injury
T6071 13417-13419 IN denotes by
T6072 13420-13426 NNP denotes RT-PCR
T6073 13427-13430 CC denotes and
T6074 13431-13436 NNP denotes ELISA
T6075 13436-13437 . denotes .
T6076 13438-13440 PRP denotes It
T6077 13441-13444 VBD denotes was
T6078 13445-13450 VBN denotes shown
T6079 13451-13455 IN denotes that
T6080 13456-13459 DT denotes the
T6081 13460-13464 NNP denotes mRNA
T6082 13465-13471 NNS denotes levels
T6083 13472-13474 IN denotes of
T6084 13475-13480 NNP denotes TNF-α
T6085 13480-13481 , denotes ,
T6086 13482-13487 NNP denotes IL-1β
T6087 13487-13488 , denotes ,
T6088 13489-13492 CC denotes and
T6089 13493-13497 NNP denotes IL-6
T6090 13498-13502 VBD denotes were
T6091 13503-13512 VBN denotes increased
T6092 13513-13518 IN denotes after
T6093 13519-13526 NN denotes scratch
T6094 13527-13529 IN denotes in
T6095 13530-13534 DT denotes both
T6096 13535-13537 NNP denotes WT
T6097 13538-13541 CC denotes and
T6098 13542-13544 NNP denotes KO
T6099 13545-13555 NNS denotes astrocytes
T6100 13556-13560 WRB denotes when
T6101 13561-13569 VBN denotes compared
T6102 13570-13574 IN denotes with
T6103 13575-13580 PRP$ denotes their
T6104 13581-13585 NN denotes sham
T6105 13586-13598 NNS denotes counterparts
T6106 13598-13599 , denotes ,
T6107 13600-13612 RB denotes respectively
T6108 13612-13613 . denotes .
T6109 13614-13622 RB denotes Moreover
T6110 13622-13623 , denotes ,
T6111 13624-13627 DT denotes the
T6112 13628-13632 NNP denotes mRNA
T6113 13633-13639 NNS denotes levels
T6114 13640-13642 IN denotes of
T6115 13643-13648 DT denotes these
T6116 13649-13658 NNS denotes cytokines
T6117 13659-13661 IN denotes in
T6118 13662-13667 NN denotes group
T6119 13668-13670 NNP denotes KO
T6120 13671-13674 NNP denotes TBI
T6121 13675-13679 VBD denotes were
T6122 13680-13684 RB denotes much
T6123 13685-13691 JJR denotes higher
T6124 13692-13696 IN denotes than
T6125 13697-13702 DT denotes those
T6126 13703-13705 IN denotes in
T6127 13706-13711 NN denotes group
T6128 13712-13714 NNP denotes WT
T6129 13715-13718 NNP denotes TBI
T6130 13719-13720 -LRB- denotes (
T6131 13720-13724 CD denotes 1.66
T6132 13725-13726 CD denotes ±
T6133 13727-13732 CD denotes 0.085
T6134 13733-13739 IN denotes versus
T6135 13740-13744 CD denotes 1.39
T6136 13745-13746 CD denotes ±
T6137 13747-13752 CD denotes 0.110
T6138 13753-13756 IN denotes for
T6139 13757-13762 NNP denotes TNF-α
T6140 13762-13763 , denotes ,
T6141 13764-13768 CD denotes 1.34
T6142 13769-13770 CD denotes ±
T6143 13771-13776 CD denotes 0.064
T6144 13777-13783 IN denotes versus
T6145 13784-13788 CD denotes 0.73
T6146 13789-13790 CD denotes ±
T6147 13791-13796 CD denotes 0.088
T6148 13797-13800 IN denotes for
T6149 13801-13806 NN denotes IL-1β
T6150 13806-13807 , denotes ,
T6151 13808-13811 CC denotes and
T6152 13812-13816 CD denotes 1.28
T6153 13817-13818 CD denotes ±
T6154 13819-13824 CD denotes 0.102
T6155 13825-13831 IN denotes versus
T6156 13832-13836 CD denotes 0.99
T6157 13837-13838 CD denotes ±
T6158 13839-13844 CD denotes 0.073
T6159 13845-13848 IN denotes for
T6160 13849-13853 NN denotes IL-6
T6161 13853-13854 . denotes .
T6162 13855-13856 NNP denotes P
T6163 13857-13858 NNP denotes <
T6164 13859-13863 CD denotes 0.01
T6165 13863-13864 -RRB- denotes )
T6166 13865-13866 -LRB- denotes (
T6167 13866-13873 NNS denotes Figures
T6168 13874-13875 CD denotes 3
T6169 13875-13876 -LRB- denotes (
T6170 13876-13877 DT denotes a
T6171 13877-13878 -RRB- denotes )
T6172 13879-13880 CD denotes 3
T6173 13880-13881 -LRB- denotes (
T6174 13881-13882 LS denotes d
T6175 13882-13883 -RRB- denotes )
T6176 13883-13884 -RRB- denotes )
T6177 13884-13885 . denotes .
T6178 13886-13889 DT denotes The
T6179 13890-13897 NNS denotes results
T6180 13898-13900 IN denotes of
T6181 13901-13906 NNP denotes ELISA
T6182 13907-13915 VBD denotes revealed
T6183 13916-13920 IN denotes that
T6184 13921-13924 DT denotes the
T6185 13925-13932 NN denotes protein
T6186 13933-13938 NN denotes level
T6187 13939-13941 IN denotes of
T6188 13942-13947 NNP denotes TNF-α
T6189 13948-13951 VBD denotes was
T6190 13952-13963 VBN denotes upregulated
T6191 13964-13969 IN denotes after
T6192 13970-13977 NN denotes scratch
T6193 13978-13984 NN denotes injury
T6194 13985-13987 IN denotes in
T6195 13988-13990 NNP denotes WT
T6196 13991-13994 CC denotes and
T6197 13995-13997 NNP denotes KO
T6198 13998-14008 NNS denotes astrocytes
T6199 14009-14013 WRB denotes when
T6200 14014-14022 VBN denotes compared
T6201 14023-14027 IN denotes with
T6202 14028-14033 PRP$ denotes their
T6203 14034-14038 NN denotes sham
T6204 14039-14051 NNS denotes counterparts
T6205 14051-14052 . denotes .
T6206 14053-14056 CC denotes And
T6207 14057-14059 PRP denotes it
T6208 14060-14063 VBD denotes was
T6209 14064-14068 RB denotes also
T6210 14069-14075 JJR denotes higher
T6211 14076-14078 IN denotes in
T6212 14079-14084 NN denotes group
T6213 14085-14087 NNP denotes KO
T6214 14088-14091 NNP denotes TBI
T6215 14092-14096 IN denotes than
T6216 14097-14099 IN denotes in
T6217 14100-14105 NN denotes group
T6218 14106-14108 NNP denotes WT
T6219 14109-14112 NNP denotes TBI
T6220 14113-14114 -LRB- denotes (
T6221 14114-14118 CD denotes 3.67
T6222 14119-14120 CD denotes ±
T6223 14121-14126 CD denotes 0.156
T6224 14127-14133 IN denotes versus
T6225 14134-14138 CD denotes 2.31
T6226 14139-14140 CD denotes ±
T6227 14141-14146 CD denotes 0.087
T6228 14146-14147 , denotes ,
T6229 14148-14149 NNP denotes P
T6230 14150-14151 VBD denotes <
T6231 14152-14156 CD denotes 0.01
T6232 14156-14157 -RRB- denotes )
T6233 14158-14159 -LRB- denotes (
T6234 14159-14165 NN denotes Figure
T6235 14166-14167 CD denotes 4
T6236 14167-14168 -LRB- denotes (
T6237 14168-14169 DT denotes a
T6238 14169-14170 -RRB- denotes )
T6239 14170-14171 -RRB- denotes )
T6240 14171-14172 . denotes .
T6241 14173-14180 JJ denotes Similar
T6242 14181-14189 NN denotes tendency
T6243 14190-14193 VBD denotes was
T6244 14194-14202 VBN denotes observed
T6245 14203-14205 IN denotes in
T6246 14206-14213 NN denotes protein
T6247 14214-14219 NN denotes level
T6248 14220-14222 IN denotes of
T6249 14223-14227 NNP denotes IL-6
T6250 14228-14231 CC denotes and
T6251 14232-14237 NNP denotes IL-1β
T6252 14237-14238 . denotes .
T6253 14239-14242 IN denotes For
T6254 14243-14247 NN denotes IL-6
T6255 14247-14248 , denotes ,
T6256 14249-14251 PRP denotes it
T6257 14252-14255 VBD denotes was
T6258 14256-14261 CD denotes 36.07
T6259 14262-14263 CD denotes ±
T6260 14264-14269 CD denotes 0.786
T6261 14270-14273 IN denotes for
T6262 14274-14279 NN denotes group
T6263 14280-14282 NNP denotes KO
T6264 14283-14286 NNP denotes TBI
T6265 14287-14292 IN denotes while
T6266 14293-14298 CD denotes 25.76
T6267 14299-14300 CD denotes ±
T6268 14301-14306 CD denotes 0.536
T6269 14307-14310 IN denotes for
T6270 14311-14316 NN denotes group
T6271 14317-14319 NNP denotes WT
T6272 14320-14323 NNP denotes TBI
T6273 14324-14325 -LRB- denotes (
T6274 14325-14326 NNP denotes P
T6275 14327-14328 CD denotes <
T6276 14329-14333 CD denotes 0.01
T6277 14333-14334 -RRB- denotes )
T6278 14335-14336 -LRB- denotes (
T6279 14336-14342 NN denotes Figure
T6280 14343-14344 CD denotes 4
T6281 14344-14345 -LRB- denotes (
T6282 14345-14346 NN denotes b
T6283 14346-14347 -RRB- denotes )
T6284 14347-14348 -RRB- denotes )
T6285 14348-14349 . denotes .
T6286 14350-14353 IN denotes For
T6287 14354-14359 NN denotes IL-1β
T6288 14359-14360 , denotes ,
T6289 14361-14363 PRP denotes it
T6290 14364-14367 VBD denotes was
T6291 14368-14374 CD denotes 190.75
T6292 14375-14376 CD denotes ±
T6293 14377-14382 CD denotes 6.339
T6294 14383-14386 IN denotes for
T6295 14387-14392 NN denotes group
T6296 14393-14395 NNP denotes KO
T6297 14396-14399 NNP denotes TBI
T6298 14400-14405 IN denotes while
T6299 14406-14412 CD denotes 154.50
T6300 14413-14414 CD denotes ±
T6301 14415-14420 CD denotes 5.348
T6302 14421-14424 IN denotes for
T6303 14425-14430 NN denotes group
T6304 14431-14433 NNP denotes WT
T6305 14434-14437 NNP denotes TBI
T6306 14438-14439 -LRB- denotes (
T6307 14439-14440 NNP denotes P
T6308 14441-14442 CD denotes <
T6309 14443-14447 CD denotes 0.01
T6310 14447-14448 -RRB- denotes )
T6311 14449-14450 -LRB- denotes (
T6312 14450-14456 NN denotes Figure
T6313 14457-14458 CD denotes 4
T6314 14458-14459 -LRB- denotes (
T6315 14459-14460 NN denotes c
T6316 14460-14461 -RRB- denotes )
T6317 14461-14462 -RRB- denotes )
T6318 14462-14463 . denotes .
T6759 14465-14468 CD denotes 3.4
T6760 14468-14469 . denotes .
T6761 14470-14480 NN denotes Expression
T6762 14481-14484 CC denotes and
T6763 14485-14493 NN denotes Activity
T6764 14494-14496 IN denotes of
T6765 14497-14501 NNP denotes MMP9
T6766 14502-14506 VBD denotes Were
T6767 14507-14514 RB denotes Greatly
T6768 14515-14523 VBN denotes Enhanced
T6769 14524-14526 IN denotes in
T6770 14527-14531 NNP denotes Nrf2
T6771 14532-14540 NNP denotes Knockout
T6772 14541-14551 NNP denotes Astrocytes
T6773 14552-14557 IN denotes after
T6774 14558-14565 NNP denotes Scratch
T6775 14566-14572 NNP denotes Injury
T6776 14573-14577 NNP denotes MMP9
T6777 14578-14580 VBZ denotes is
T6778 14581-14583 DT denotes an
T6779 14584-14593 JJ denotes important
T6780 14594-14604 NN denotes gelatinase
T6781 14605-14607 TO denotes to
T6782 14608-14614 VB denotes induce
T6783 14615-14617 CC denotes or
T6784 14618-14627 VB denotes aggravate
T6785 14628-14631 DT denotes the
T6786 14632-14644 NN denotes inflammation
T6787 14645-14652 NN denotes process
T6788 14652-14653 . denotes .
T6789 14654-14656 IN denotes In
T6790 14657-14660 DT denotes the
T6791 14661-14668 JJ denotes present
T6792 14669-14674 NN denotes study
T6793 14674-14675 , denotes ,
T6794 14676-14678 PRP denotes we
T6795 14679-14687 VBD denotes elevated
T6796 14688-14691 DT denotes the
T6797 14692-14696 NNP denotes mRNA
T6798 14696-14697 , denotes ,
T6799 14698-14705 NN denotes protein
T6800 14706-14712 NNS denotes levels
T6801 14712-14713 , denotes ,
T6802 14714-14717 CC denotes and
T6803 14718-14726 NN denotes activity
T6804 14727-14729 IN denotes of
T6805 14730-14734 NNP denotes MMP9
T6806 14735-14737 IN denotes in
T6807 14738-14748 NNS denotes astrocytes
T6808 14749-14751 IN denotes at
T6809 14752-14754 CD denotes 24
T6810 14755-14756 NN denotes h
T6811 14757-14762 IN denotes after
T6812 14763-14770 NN denotes scratch
T6813 14771-14777 NN denotes injury
T6814 14778-14780 IN denotes by
T6815 14781-14787 NNP denotes RT-PCR
T6816 14787-14788 , denotes ,
T6817 14789-14796 JJ denotes western
T6818 14797-14801 NN denotes blot
T6819 14801-14802 , denotes ,
T6820 14803-14806 CC denotes and
T6821 14807-14815 JJ denotes gelatine
T6822 14816-14826 NN denotes zymography
T6823 14826-14827 . denotes .
T6824 14828-14838 NN denotes Expression
T6825 14839-14841 IN denotes of
T6826 14842-14846 NNP denotes MMP9
T6827 14847-14850 VBD denotes was
T6828 14851-14859 VBN denotes elevated
T6829 14860-14865 IN denotes after
T6830 14866-14873 NN denotes scratch
T6831 14874-14880 NN denotes injury
T6832 14881-14883 IN denotes in
T6833 14884-14886 NNP denotes WT
T6834 14887-14890 CC denotes and
T6835 14891-14893 NNP denotes KO
T6836 14894-14904 NNS denotes astrocytes
T6837 14905-14907 IN denotes as
T6838 14908-14916 VBN denotes compared
T6839 14917-14921 IN denotes with
T6840 14922-14927 PRP$ denotes their
T6841 14928-14932 NN denotes sham
T6842 14933-14945 NNS denotes counterparts
T6843 14945-14946 . denotes .
T6844 14947-14950 DT denotes The
T6845 14951-14955 NNP denotes mRNA
T6846 14956-14961 NN denotes level
T6847 14962-14964 IN denotes of
T6848 14965-14969 NNP denotes MMP9
T6849 14970-14973 VBD denotes was
T6850 14974-14980 JJR denotes higher
T6851 14981-14983 IN denotes in
T6852 14984-14989 NN denotes group
T6853 14990-14992 NNP denotes KO
T6854 14993-14996 NNP denotes TBI
T6855 14997-15001 IN denotes than
T6856 15002-15004 IN denotes in
T6857 15005-15010 NN denotes group
T6858 15011-15013 NNP denotes WT
T6859 15014-15017 NNP denotes TBI
T6860 15018-15019 -LRB- denotes (
T6861 15019-15023 CD denotes 1.36
T6862 15024-15025 CD denotes ±
T6863 15026-15031 CD denotes 0.090
T6864 15032-15038 IN denotes versus
T6865 15039-15043 CD denotes 1.01
T6866 15044-15045 CD denotes ±
T6867 15046-15051 CD denotes 0.068
T6868 15051-15052 , denotes ,
T6869 15053-15054 NNP denotes P
T6870 15055-15056 VBD denotes <
T6871 15057-15061 CD denotes 0.01
T6872 15061-15062 -RRB- denotes )
T6873 15063-15064 -LRB- denotes (
T6874 15064-15071 NNS denotes Figures
T6875 15072-15073 CD denotes 3
T6876 15073-15074 -LRB- denotes (
T6877 15074-15075 DT denotes a
T6878 15075-15076 -RRB- denotes )
T6879 15077-15080 CC denotes and
T6880 15081-15082 CD denotes 3
T6881 15082-15083 -LRB- denotes (
T6882 15083-15084 LS denotes e
T6883 15084-15085 -RRB- denotes )
T6884 15085-15086 -RRB- denotes )
T6885 15086-15087 . denotes .
T6886 15088-15099 JJ denotes Significant
T6887 15100-15110 NN denotes difference
T6888 15111-15114 VBD denotes was
T6889 15115-15119 RB denotes also
T6890 15120-15130 VBN denotes discovered
T6891 15131-15133 IN denotes in
T6892 15134-15138 CD denotes MMP9
T6893 15139-15146 NN denotes protein
T6894 15147-15152 NN denotes level
T6895 15153-15155 IN denotes by
T6896 15156-15163 JJ denotes western
T6897 15164-15168 NN denotes blot
T6898 15168-15169 , denotes ,
T6899 15170-15172 IN denotes as
T6900 15173-15177 CD denotes 1.44
T6901 15178-15179 CD denotes ±
T6902 15180-15185 CD denotes 0.076
T6903 15186-15189 IN denotes for
T6904 15190-15195 NN denotes group
T6905 15196-15198 NNP denotes KO
T6906 15199-15202 NNP denotes TBI
T6907 15203-15206 CC denotes and
T6908 15207-15211 CD denotes 1.13
T6909 15212-15213 CD denotes ±
T6910 15214-15219 CD denotes 0.048
T6911 15220-15223 IN denotes for
T6912 15224-15229 NN denotes group
T6913 15230-15232 NNP denotes WT
T6914 15233-15236 NNP denotes TBI
T6915 15237-15238 -LRB- denotes (
T6916 15238-15239 NNP denotes P
T6917 15240-15241 CD denotes <
T6918 15242-15246 CD denotes 0.01
T6919 15246-15247 -RRB- denotes )
T6920 15248-15249 -LRB- denotes (
T6921 15249-15255 NN denotes Figure
T6922 15256-15257 CD denotes 5
T6923 15257-15258 -RRB- denotes )
T6924 15258-15259 . denotes .
T6925 15260-15268 JJ denotes Gelatine
T6926 15269-15279 NN denotes zymography
T6927 15280-15288 VBD denotes revealed
T6928 15289-15295 JJR denotes higher
T6929 15296-15300 JJ denotes MMP9
T6930 15301-15309 NN denotes activity
T6931 15310-15312 IN denotes in
T6932 15313-15318 NN denotes group
T6933 15319-15321 NNP denotes KO
T6934 15322-15325 NNP denotes TBI
T6935 15326-15330 IN denotes than
T6936 15331-15335 DT denotes that
T6937 15336-15338 IN denotes in
T6938 15339-15344 NN denotes group
T6939 15345-15347 NNP denotes WT
T6940 15348-15351 NNP denotes TBI
T6941 15352-15355 RB denotes too
T6942 15356-15357 -LRB- denotes (
T6943 15357-15363 CD denotes 101.76
T6944 15364-15365 CD denotes ±
T6945 15366-15371 CD denotes 6.343
T6946 15372-15378 IN denotes versus
T6947 15379-15384 CD denotes 76.32
T6948 15385-15386 CD denotes ±
T6949 15387-15392 CD denotes 3.388
T6950 15392-15393 , denotes ,
T6951 15394-15395 NNP denotes P
T6952 15396-15397 VBD denotes <
T6953 15398-15402 CD denotes 0.01
T6954 15402-15403 -RRB- denotes )
T6955 15404-15405 -LRB- denotes (
T6956 15405-15411 NN denotes Figure
T6957 15412-15413 CD denotes 6
T6958 15413-15414 -RRB- denotes )
T6959 15414-15415 . denotes .
T8743 15431-15434 DT denotes The
T8744 15435-15442 JJ denotes present
T8745 15443-15448 NN denotes study
T8746 15449-15461 VBD denotes demonstrated
T8747 15462-15466 IN denotes that
T8748 15467-15474 NN denotes scratch
T8749 15475-15481 NN denotes injury
T8750 15482-15489 VBD denotes induced
T8751 15490-15493 DT denotes the
T8752 15494-15506 NN denotes upregulation
T8753 15507-15509 IN denotes of
T8754 15510-15515 NNP denotes NF-κB
T8755 15516-15519 NNP denotes DNA
T8756 15520-15527 JJ denotes binding
T8757 15528-15536 NN denotes activity
T8758 15537-15540 CC denotes and
T8759 15541-15555 NN denotes overexpression
T8760 15556-15558 IN denotes of
T8761 15559-15564 NNP denotes TNF-α
T8762 15564-15565 , denotes ,
T8763 15566-15571 NNP denotes IL-1β
T8764 15571-15572 , denotes ,
T8765 15573-15577 NNP denotes IL-6
T8766 15577-15578 , denotes ,
T8767 15579-15582 CC denotes and
T8768 15583-15587 NNP denotes MMP9
T8769 15588-15590 IN denotes in
T8770 15591-15599 JJ denotes cultured
T8771 15600-15610 NNS denotes astrocytes
T8772 15610-15611 . denotes .
T8773 15612-15616 RB denotes Also
T8774 15617-15619 PRP denotes we
T8775 15620-15628 VBD denotes revealed
T8776 15629-15633 IN denotes that
T8777 15634-15641 NN denotes scratch
T8778 15642-15648 NN denotes injury
T8779 15649-15656 VBD denotes induced
T8780 15657-15663 JJR denotes higher
T8781 15664-15672 NN denotes activity
T8782 15673-15675 IN denotes of
T8783 15676-15681 NNP denotes NF-κB
T8784 15682-15685 CC denotes and
T8785 15686-15694 JJ denotes enhanced
T8786 15695-15705 NN denotes expression
T8787 15706-15708 IN denotes of
T8788 15709-15724 JJ denotes proinflammatory
T8789 15725-15734 NNS denotes cytokines
T8790 15735-15737 IN denotes in
T8791 15738-15742 JJ denotes Nrf2
T8792 15743-15751 NN denotes knockout
T8793 15752-15760 VBD denotes cultured
T8794 15761-15771 NNS denotes astrocytes
T8795 15772-15776 IN denotes than
T8796 15777-15782 DT denotes those
T8797 15783-15785 IN denotes in
T8798 15786-15794 NN denotes wildtype
T8799 15795-15805 NNS denotes astrocytes
T8800 15806-15809 IN denotes for
T8801 15810-15813 DT denotes the
T8802 15814-15819 JJ denotes first
T8803 15820-15824 NN denotes time
T8804 15824-15825 . denotes .
T8805 15826-15828 PRP denotes It
T8806 15829-15832 VBZ denotes has
T8807 15833-15837 VBN denotes been
T8808 15838-15850 VBN denotes demonstrated
T8809 15851-15855 IN denotes that
T8810 15856-15861 NNP denotes NF-κB
T8811 15862-15864 VBZ denotes is
T8812 15865-15874 VBN denotes activated
T8813 15875-15877 IN denotes in
T8814 15878-15883 NN denotes brain
T8815 15884-15887 CC denotes and
T8816 15888-15894 JJ denotes spinal
T8817 15895-15899 NN denotes cord
T8818 15900-15905 IN denotes after
T8819 15906-15915 JJ denotes traumatic
T8820 15916-15922 NN denotes injury
T8821 15923-15924 NN denotes [
T8822 15924-15925 CD denotes 2
T8823 15925-15926 , denotes ,
T8824 15927-15928 CD denotes 9
T8825 15928-15929 NN denotes ]
T8826 15929-15930 . denotes .
T8827 15931-15933 IN denotes As
T8828 15934-15935 DT denotes a
T8829 15936-15946 NN denotes transcript
T8830 15947-15953 NN denotes factor
T8831 15953-15954 , denotes ,
T8832 15955-15960 JJ denotes NF-κB
T8833 15961-15966 NNS denotes binds
T8834 15967-15971 IN denotes with
T8835 15972-15975 NNP denotes DNA
T8836 15976-15980 IN denotes once
T8837 15981-15983 PRP denotes it
T8838 15984-15987 VBD denotes was
T8839 15988-15997 VBN denotes activated
T8840 15998-16001 CC denotes and
T8841 16002-16009 VBZ denotes induces
T8842 16010-16023 NN denotes transcription
T8843 16024-16026 IN denotes of
T8844 16027-16031 NNP denotes MMP9
T8845 16032-16035 CC denotes and
T8846 16036-16037 DT denotes a
T8847 16038-16045 NN denotes battery
T8848 16046-16048 IN denotes of
T8849 16049-16064 JJ denotes proinflammatory
T8850 16065-16074 NNS denotes cytokines
T8851 16074-16075 , denotes ,
T8852 16076-16085 VBG denotes including
T8853 16086-16091 NNP denotes TNF-α
T8854 16091-16092 , denotes ,
T8855 16093-16098 NNP denotes IL-1β
T8856 16098-16099 , denotes ,
T8857 16100-16103 CC denotes and
T8858 16104-16108 NNP denotes IL-6
T8859 16108-16109 , denotes ,
T8860 16110-16112 IN denotes in
T8861 16113-16118 NN denotes brain
T8862 16119-16126 NNS denotes tissues
T8863 16127-16132 IN denotes after
T8864 16133-16136 NNP denotes TBI
T8865 16137-16138 NNP denotes [
T8866 16138-16139 CD denotes 3
T8867 16139-16140 , denotes ,
T8868 16141-16143 CD denotes 10
T8869 16143-16144 , denotes ,
T8870 16145-16147 CD denotes 11
T8871 16147-16148 NN denotes ]
T8872 16148-16149 . denotes .
T8873 16150-16153 PRP$ denotes Our
T8874 16154-16161 NNS denotes results
T8875 16162-16166 RB denotes also
T8876 16167-16175 VBD denotes revealed
T8877 16176-16180 IN denotes that
T8878 16181-16188 NN denotes scratch
T8879 16189-16195 NN denotes injury
T8880 16196-16203 VBD denotes induced
T8881 16204-16213 NN denotes elevation
T8882 16214-16216 IN denotes of
T8883 16217-16222 NNP denotes NF-κB
T8884 16223-16226 NNP denotes DNA
T8885 16227-16234 JJ denotes binding
T8886 16235-16243 NN denotes activity
T8887 16243-16244 , denotes ,
T8888 16245-16259 NN denotes overexpression
T8889 16260-16262 IN denotes of
T8890 16263-16267 NNP denotes MMP9
T8891 16267-16268 , denotes ,
T8892 16269-16272 CC denotes and
T8893 16273-16288 JJ denotes proinflammatory
T8894 16289-16298 NNS denotes mediators
T8895 16299-16308 VBN denotes mentioned
T8896 16309-16314 IN denotes above
T8897 16315-16317 IN denotes in
T8898 16318-16326 JJ denotes cultured
T8899 16327-16337 NNS denotes astrocytes
T8900 16337-16338 . denotes .
T8901 16339-16341 PRP denotes It
T8902 16342-16345 VBZ denotes has
T8903 16346-16350 VBN denotes been
T8904 16351-16363 VBN denotes demonstrated
T8905 16364-16368 IN denotes that
T8906 16369-16374 EX denotes there
T8907 16375-16377 VBZ denotes is
T8908 16378-16380 DT denotes an
T8909 16381-16395 JJ denotes autoregulatory
T8910 16396-16400 NN denotes loop
T8911 16401-16406 IN denotes among
T8912 16407-16412 DT denotes these
T8913 16413-16428 JJ denotes proinflammatory
T8914 16429-16438 NNS denotes mediators
T8915 16438-16439 . denotes .
T8916 16440-16443 IN denotes For
T8917 16444-16451 NN denotes example
T8918 16451-16452 , denotes ,
T8919 16453-16458 NNP denotes TNF-α
T8920 16459-16462 CC denotes and
T8921 16463-16468 NNP denotes IL-1β
T8922 16469-16472 VBP denotes are
T8923 16473-16479 JJ denotes potent
T8924 16480-16491 NNS denotes stimulators
T8925 16492-16495 IN denotes for
T8926 16496-16500 NNP denotes MMP9
T8927 16501-16503 IN denotes in
T8928 16504-16514 NNS denotes astrocytes
T8929 16515-16516 NNP denotes [
T8930 16516-16518 CD denotes 12
T8931 16518-16519 , denotes ,
T8932 16520-16522 CD denotes 13
T8933 16522-16523 NNP denotes ]
T8934 16523-16524 , denotes ,
T8935 16525-16528 CC denotes and
T8936 16529-16533 NNP denotes IL-6
T8937 16534-16541 VBZ denotes induces
T8938 16542-16556 NN denotes overexpression
T8939 16557-16559 IN denotes of
T8940 16560-16564 NNP denotes MMP9
T8941 16565-16567 IN denotes in
T8942 16568-16573 JJ denotes human
T8943 16574-16579 NN denotes colon
T8944 16580-16589 NN denotes carcinoma
T8945 16590-16595 NNS denotes cells
T8946 16596-16597 NNP denotes [
T8947 16597-16599 CD denotes 14
T8948 16599-16600 NNP denotes ]
T8949 16600-16601 , denotes ,
T8950 16602-16605 CC denotes and
T8951 16606-16611 NNP denotes TNF-α
T8952 16612-16615 CC denotes and
T8953 16616-16621 NNP denotes IL-1β
T8954 16622-16626 RB denotes also
T8955 16627-16630 MD denotes can
T8956 16631-16637 VB denotes induce
T8957 16638-16648 NN denotes activation
T8958 16649-16651 IN denotes of
T8959 16652-16657 NNP denotes NF-κB
T8960 16658-16659 NNP denotes [
T8961 16659-16661 CD denotes 15
T8962 16661-16662 , denotes ,
T8963 16663-16665 CD denotes 16
T8964 16665-16666 NN denotes ]
T8965 16666-16667 . denotes .
T8966 16668-16672 DT denotes This
T8967 16673-16687 JJ denotes autoregulatory
T8968 16688-16692 NN denotes loop
T8969 16693-16702 RB denotes extremely
T8970 16703-16713 VBZ denotes aggravates
T8971 16714-16717 DT denotes the
T8972 16718-16726 JJ denotes damaging
T8973 16727-16733 NN denotes effect
T8974 16734-16736 IN denotes of
T8975 16737-16749 NN denotes inflammation
T8976 16750-16753 CC denotes and
T8977 16754-16761 VBZ denotes induces
T8978 16762-16771 JJ denotes secondary
T8979 16772-16778 NN denotes injury
T8980 16779-16781 TO denotes to
T8981 16782-16787 NN denotes brain
T8982 16787-16788 . denotes .
T8983 16789-16791 PRP denotes It
T8984 16792-16794 VBZ denotes is
T8985 16795-16796 DT denotes a
T8986 16797-16801 JJ denotes good
T8987 16802-16808 NN denotes choice
T8988 16809-16812 IN denotes for
T8989 16813-16822 VBG denotes targeting
T8990 16823-16825 IN denotes on
T8991 16826-16828 DT denotes an
T8992 16829-16837 JJ denotes upstream
T8993 16838-16844 NN denotes factor
T8994 16845-16847 TO denotes to
T8995 16848-16855 VB denotes prevent
T8996 16856-16860 JJ denotes such
T8997 16861-16875 JJ denotes autoregulatory
T8998 16876-16880 NN denotes loop
T8999 16881-16886 IN denotes after
T9000 16887-16890 NNP denotes TBI
T9001 16890-16891 . denotes .
T9002 16892-16900 JJ denotes Nrf2-ARE
T9003 16901-16908 NN denotes pathway
T9004 16909-16912 VBZ denotes has
T9005 16913-16917 VBN denotes been
T9006 16918-16924 VBN denotes proved
T9007 16925-16927 TO denotes to
T9008 16928-16930 VB denotes be
T9009 16931-16934 DT denotes the
T9010 16935-16938 JJ denotes key
T9011 16939-16948 NN denotes regulator
T9012 16949-16951 IN denotes in
T9013 16952-16960 VBG denotes reducing
T9014 16961-16970 JJ denotes oxidative
T9015 16971-16977 NN denotes stress
T9016 16977-16978 , denotes ,
T9017 16979-16991 JJ denotes inflammatory
T9018 16992-16998 NN denotes damage
T9019 16998-16999 , denotes ,
T9020 17000-17003 CC denotes and
T9021 17004-17016 NN denotes accumulation
T9022 17017-17019 IN denotes of
T9023 17020-17025 JJ denotes toxic
T9024 17026-17037 NNS denotes metabolites
T9025 17037-17038 , denotes ,
T9026 17039-17044 WDT denotes which
T9027 17045-17048 VBP denotes are
T9028 17049-17052 DT denotes all
T9029 17053-17061 VBN denotes involved
T9030 17062-17064 IN denotes in
T9031 17065-17068 NNP denotes TBI
T9032 17068-17069 . denotes .
T9033 17070-17073 PRP$ denotes Our
T9034 17074-17082 JJ denotes previous
T9035 17083-17088 NN denotes study
T9036 17089-17092 VBZ denotes has
T9037 17093-17099 VBN denotes proved
T9038 17100-17103 DT denotes the
T9039 17104-17116 NN denotes augmentation
T9040 17117-17119 IN denotes of
T9041 17120-17124 NNP denotes Nrf2
T9042 17125-17127 IN denotes in
T9043 17128-17133 NN denotes brain
T9044 17134-17140 NN denotes tissue
T9045 17141-17146 IN denotes after
T9046 17147-17150 NNP denotes TBI
T9047 17151-17152 NNP denotes [
T9048 17152-17154 CD denotes 17
T9049 17154-17155 NNP denotes ]
T9050 17155-17156 . denotes .
T9051 17157-17165 JJ denotes Enhanced
T9052 17166-17171 NN denotes level
T9053 17172-17174 IN denotes of
T9054 17175-17179 JJ denotes Nrf2
T9055 17180-17189 NNS denotes activates
T9056 17190-17203 NN denotes transcription
T9057 17204-17206 IN denotes of
T9058 17207-17208 DT denotes a
T9059 17209-17214 NN denotes group
T9060 17215-17217 IN denotes of
T9061 17218-17229 JJ denotes antioxidant
T9062 17230-17235 NNS denotes genes
T9063 17235-17236 , denotes ,
T9064 17237-17241 JJ denotes such
T9065 17242-17244 IN denotes as
T9066 17245-17249 NN denotes heme
T9067 17250-17261 JJ denotes oxygenase-1
T9068 17262-17263 -LRB- denotes (
T9069 17263-17267 JJ denotes HO-1
T9070 17267-17268 -RRB- denotes )
T9071 17269-17272 CC denotes and
T9072 17273-17276 NNP denotes NAD
T9073 17277-17278 -LRB- denotes (
T9074 17278-17279 NNP denotes P
T9075 17279-17280 -RRB- denotes )
T9076 17280-17281 NNP denotes H
T9077 17281-17282 : denotes :
T9078 17283-17290 VB denotes quinone
T9079 17291-17307 JJ denotes oxidoreductase-1
T9080 17308-17309 -LRB- denotes (
T9081 17309-17313 CD denotes NQO1
T9082 17313-17314 -RRB- denotes )
T9083 17314-17315 , denotes ,
T9084 17316-17321 WDT denotes which
T9085 17322-17327 MD denotes would
T9086 17328-17340 RB denotes subsequently
T9087 17341-17347 VB denotes reduce
T9088 17348-17351 DT denotes the
T9089 17352-17358 NN denotes damage
T9090 17359-17361 IN denotes in
T9091 17362-17367 NN denotes brain
T9092 17368-17369 NNP denotes [
T9093 17369-17371 CD denotes 18
T9094 17371-17372 NNP denotes ]
T9095 17372-17373 . denotes .
T9096 17374-17384 NNP denotes Postinjury
T9097 17385-17399 NN denotes administration
T9098 17400-17402 IN denotes of
T9099 17403-17406 NNP denotes SFN
T9100 17406-17407 , denotes ,
T9101 17408-17410 DT denotes an
T9102 17411-17418 NN denotes inducer
T9103 17419-17421 IN denotes of
T9104 17422-17426 NNP denotes Nrf2
T9105 17426-17427 , denotes ,
T9106 17428-17441 RB denotes significantly
T9107 17442-17450 VBZ denotes improves
T9108 17451-17458 JJ denotes spatial
T9109 17459-17465 NN denotes memory
T9110 17466-17468 IN denotes of
T9111 17469-17472 NN denotes rat
T9112 17473-17476 CC denotes and
T9113 17477-17486 VBZ denotes decreases
T9114 17487-17490 DT denotes the
T9115 17491-17507 NN denotes immunoreactivity
T9116 17508-17511 IN denotes for
T9117 17512-17528 JJ denotes 4-Hydroxynonenal
T9118 17529-17530 -LRB- denotes (
T9119 17530-17535 JJ denotes 4-HNE
T9120 17535-17536 -RRB- denotes )
T9121 17536-17537 , denotes ,
T9122 17538-17539 DT denotes a
T9123 17540-17546 NN denotes marker
T9124 17547-17549 IN denotes of
T9125 17550-17555 JJ denotes lipid
T9126 17556-17568 NN denotes peroxidation
T9127 17568-17569 , denotes ,
T9128 17570-17572 IN denotes in
T9129 17573-17576 DT denotes the
T9130 17577-17583 NN denotes cortex
T9131 17584-17587 CC denotes and
T9132 17588-17591 DT denotes the
T9133 17592-17595 NNP denotes CA3
T9134 17596-17604 NN denotes subfield
T9135 17605-17607 IN denotes of
T9136 17608-17619 NN denotes hippocampus
T9137 17620-17625 IN denotes after
T9138 17626-17629 NNP denotes TBI
T9139 17630-17631 NNP denotes [
T9140 17631-17633 CD denotes 19
T9141 17633-17634 NNP denotes ]
T9142 17634-17635 . denotes .
T9143 17636-17638 IN denotes On
T9144 17639-17642 DT denotes the
T9145 17643-17648 JJ denotes other
T9146 17649-17653 NN denotes hand
T9147 17653-17654 , denotes ,
T9148 17655-17669 JJ denotes Nrf2-deficient
T9149 17670-17674 NNS denotes mice
T9150 17675-17681 VBP denotes appear
T9151 17682-17686 JJR denotes more
T9152 17687-17698 JJ denotes susceptible
T9153 17699-17701 TO denotes to
T9154 17702-17705 NNP denotes TBI
T9155 17705-17706 . denotes .
T9156 17707-17716 NN denotes Depletion
T9157 17717-17719 IN denotes of
T9158 17720-17724 JJ denotes Nrf2
T9159 17725-17732 VBZ denotes induces
T9160 17733-17739 JJR denotes higher
T9161 17740-17750 NN denotes expression
T9162 17751-17753 IN denotes of
T9163 17754-17769 JJ denotes proinflammatory
T9164 17770-17779 NNS denotes mediators
T9165 17780-17782 IN denotes in
T9166 17783-17788 NN denotes brain
T9167 17789-17794 IN denotes after
T9168 17795-17798 NNP denotes TBI
T9169 17799-17800 NNP denotes [
T9170 17800-17802 CD denotes 20
T9171 17802-17803 NNP denotes ]
T9172 17803-17804 . denotes .
T9173 17805-17809 RB denotes Here
T9174 17809-17810 , denotes ,
T9175 17811-17814 PRP$ denotes our
T9176 17815-17822 NNS denotes results
T9177 17823-17831 VBD denotes revealed
T9178 17832-17836 IN denotes that
T9179 17837-17851 NN denotes overexpression
T9180 17852-17854 IN denotes of
T9181 17855-17860 NNP denotes TNF-α
T9182 17860-17861 , denotes ,
T9183 17862-17867 NNP denotes IL-1β
T9184 17867-17868 , denotes ,
T9185 17869-17873 NNP denotes IL-6
T9186 17873-17874 , denotes ,
T9187 17875-17878 CC denotes and
T9188 17879-17883 NNP denotes MMP9
T9189 17884-17889 IN denotes after
T9190 17890-17897 NN denotes scratch
T9191 17898-17904 NN denotes injury
T9192 17905-17908 VBD denotes was
T9193 17909-17913 RBR denotes more
T9194 17914-17924 VBN denotes aggravated
T9195 17925-17927 IN denotes in
T9196 17928-17936 JJ denotes cultured
T9197 17937-17941 JJ denotes Nrf2
T9198 17942-17950 NN denotes knockout
T9199 17951-17961 NNS denotes astrocytes
T9200 17962-17966 IN denotes than
T9201 17967-17969 IN denotes in
T9202 17970-17978 NN denotes wildtype
T9203 17979-17990 NNS denotes astrocyetes
T9204 17991-17994 IN denotes for
T9205 17995-17998 DT denotes the
T9206 17999-18004 JJ denotes first
T9207 18005-18009 NN denotes time
T9208 18009-18010 , denotes ,
T9209 18011-18014 CC denotes and
T9210 18015-18029 NN denotes overexpression
T9211 18030-18032 IN denotes of
T9212 18033-18038 DT denotes these
T9213 18039-18054 JJ denotes proinflammatory
T9214 18055-18064 NNS denotes mediators
T9215 18065-18068 VBD denotes led
T9216 18069-18071 TO denotes to
T9217 18072-18076 JJR denotes more
T9218 18077-18087 NNS denotes astrocytes
T9219 18088-18094 NNS denotes deaths
T9220 18094-18095 . denotes .
T9221 18096-18100 NNP denotes Data
T9222 18101-18109 VBD denotes obtained
T9223 18110-18114 IN denotes from
T9224 18115-18121 JJ denotes animal
T9225 18122-18129 NNS denotes studies
T9226 18130-18137 VBP denotes suggest
T9227 18138-18141 DT denotes the
T9228 18142-18153 NN denotes possibility
T9229 18154-18158 WDT denotes that
T9230 18159-18170 JJ denotes antioxidant
T9231 18171-18177 NN denotes effect
T9232 18178-18180 IN denotes of
T9233 18181-18185 NNP denotes Nrf2
T9234 18186-18189 MD denotes may
T9235 18190-18192 VB denotes be
T9236 18193-18201 VBN denotes achieved
T9237 18202-18204 IN denotes by
T9238 18205-18216 NN denotes suppression
T9239 18217-18219 IN denotes of
T9240 18220-18235 JJ denotes proinflammatory
T9241 18236-18244 NNS denotes pathways
T9242 18245-18250 WDT denotes which
T9243 18251-18254 VBP denotes are
T9244 18255-18263 VBN denotes mediated
T9245 18264-18266 IN denotes by
T9246 18267-18272 JJ denotes NF-κB
T9247 18273-18282 VBG denotes signaling
T9248 18282-18283 . denotes .
T9249 18284-18298 NNP denotes Administration
T9250 18299-18301 IN denotes of
T9251 18302-18305 NNP denotes SFN
T9252 18306-18308 VBZ denotes is
T9253 18309-18314 VBN denotes found
T9254 18315-18317 TO denotes to
T9255 18318-18320 VB denotes be
T9256 18321-18325 JJ denotes able
T9257 18326-18328 TO denotes to
T9258 18329-18336 VB denotes inhibit
T9259 18337-18342 NNP denotes IKK/I
T9260 18342-18344 NNP denotes κB
T9261 18345-18360 NN denotes phosphorylation
T9262 18361-18364 CC denotes and
T9263 18365-18368 CD denotes p65
T9264 18369-18374 JJ denotes NF-κB
T9265 18375-18382 NN denotes subunit
T9266 18383-18390 JJ denotes nuclear
T9267 18391-18404 NN denotes translocation
T9268 18404-18405 , denotes ,
T9269 18406-18418 RB denotes consequently
T9270 18419-18430 VBG denotes alleviating
T9271 18431-18436 JJ denotes NF-κB
T9272 18437-18446 VBG denotes signaling
T9273 18447-18448 NNP denotes [
T9274 18448-18450 CD denotes 21
T9275 18450-18451 NNP denotes ]
T9276 18451-18452 . denotes .
T9277 18453-18456 CC denotes And
T9278 18457-18462 JJ denotes NF-κB
T9279 18463-18473 NN denotes activation
T9280 18474-18481 VBN denotes induced
T9281 18482-18484 IN denotes by
T9282 18485-18503 NN denotes lipopolysaccharide
T9283 18504-18505 -LRB- denotes (
T9284 18505-18508 NNP denotes LPS
T9285 18508-18509 -RRB- denotes )
T9286 18510-18515 MD denotes could
T9287 18516-18518 VB denotes be
T9288 18519-18529 VBN denotes attenuated
T9289 18530-18532 IN denotes by
T9290 18533-18540 JJ denotes diverse
T9291 18541-18545 JJ denotes Nrf2
T9292 18546-18556 NNS denotes activators
T9293 18556-18557 , denotes ,
T9294 18558-18562 JJ denotes such
T9295 18563-18565 IN denotes as
T9296 18566-18569 NNP denotes SFN
T9297 18570-18573 CC denotes and
T9298 18574-18582 NN denotes curcumin
T9299 18583-18584 -LRB- denotes (
T9300 18584-18587 NNP denotes CUR
T9301 18587-18588 -RRB- denotes )
T9302 18589-18590 NNP denotes [
T9303 18590-18592 CD denotes 22
T9304 18592-18593 NNP denotes ]
T9305 18593-18594 . denotes .
T9306 18595-18606 RB denotes Furthermore
T9307 18606-18607 , denotes ,
T9308 18608-18611 PRP$ denotes our
T9309 18612-18620 JJ denotes previous
T9310 18621-18628 NNS denotes studies
T9311 18629-18637 VBP denotes indicate
T9312 18638-18642 IN denotes that
T9313 18643-18652 NN denotes depletion
T9314 18653-18655 IN denotes of
T9315 18656-18660 JJ denotes Nrf2
T9316 18661-18668 VBZ denotes induces
T9317 18669-18681 NN denotes augmentation
T9318 18682-18684 IN denotes of
T9319 18685-18690 JJ denotes NF-κB
T9320 18691-18699 NN denotes activity
T9321 18700-18703 CC denotes and
T9322 18704-18716 JJ denotes inflammatory
T9323 18717-18725 NN denotes response
T9324 18726-18728 IN denotes in
T9325 18729-18733 NN denotes lung
T9326 18733-18734 , denotes ,
T9327 18735-18740 NN denotes brain
T9328 18740-18741 , denotes ,
T9329 18742-18745 CC denotes and
T9330 18746-18755 JJ denotes intestine
T9331 18756-18761 IN denotes after
T9332 18762-18765 NNP denotes TBI
T9333 18766-18767 NNP denotes [
T9334 18767-18768 CD denotes 4
T9335 18768-18769 , denotes ,
T9336 18770-18771 CD denotes 5
T9337 18771-18772 , denotes ,
T9338 18773-18775 CD denotes 23
T9339 18775-18776 NNP denotes ]
T9340 18776-18777 . denotes .
T9341 18778-18785 NNS denotes Results
T9342 18786-18790 IN denotes from
T9343 18791-18795 DT denotes this
T9344 18796-18801 NN denotes study
T9345 18802-18809 JJ denotes further
T9346 18810-18819 VBD denotes confirmed
T9347 18820-18824 JJ denotes such
T9348 18825-18837 NN denotes relationship
T9349 18838-18845 VBD denotes existed
T9350 18846-18848 IN denotes in
T9351 18849-18857 JJ denotes cultured
T9352 18858-18868 NNS denotes astrocytes
T9353 18869-18874 IN denotes after
T9354 18875-18882 NN denotes scratch
T9355 18883-18889 NN denotes injury
T9356 18889-18890 . denotes .
T9357 18891-18899 VBN denotes Enhanced
T9358 18900-18910 NN denotes activation
T9359 18911-18913 IN denotes of
T9360 18914-18919 NNP denotes NF-κB
T9361 18920-18922 VBZ denotes is
T9362 18923-18927 RB denotes also
T9363 18928-18938 VBN denotes discovered
T9364 18939-18941 IN denotes in
T9365 18942-18946 NN denotes lung
T9366 18946-18947 , denotes ,
T9367 18948-18959 NNS denotes macrophages
T9368 18959-18960 , denotes ,
T9369 18961-18964 CC denotes and
T9370 18965-18970 NN denotes mouse
T9371 18971-18980 JJ denotes embryonic
T9372 18981-18992 NNS denotes fibroblasts
T9373 18993-18995 IN denotes of
T9374 18996-19010 JJ denotes Nrf2-deficient
T9375 19011-19015 NNS denotes mice
T9376 19016-19021 IN denotes after
T9377 19022-19034 JJ denotes experimental
T9378 19035-19041 NN denotes sepsis
T9379 19042-19043 NNP denotes [
T9380 19043-19045 CD denotes 24
T9381 19045-19046 NNP denotes ]
T9382 19046-19047 . denotes .
T9383 19048-19061 RB denotes Interestingly
T9384 19061-19062 , denotes ,
T9385 19063-19065 PRP denotes it
T9386 19066-19068 VBZ denotes is
T9387 19069-19077 VBN denotes reported
T9388 19078-19082 IN denotes that
T9389 19083-19088 NNP denotes NF-κB
T9390 19089-19092 MD denotes can
T9391 19093-19100 VB denotes inhibit
T9392 19101-19105 NNP denotes Nrf2
T9393 19106-19108 IN denotes at
T9394 19109-19124 JJ denotes transcriptional
T9395 19125-19130 NN denotes level
T9396 19130-19131 . denotes .
T9397 19132-19137 NNP denotes NF-κB
T9398 19138-19141 CD denotes p65
T9399 19142-19149 NN denotes subunit
T9400 19150-19159 VBD denotes repressed
T9401 19160-19163 DT denotes the
T9402 19164-19172 JJ denotes Nrf2-ARE
T9403 19173-19180 NN denotes pathway
T9404 19181-19183 IN denotes at
T9405 19184-19199 JJ denotes transcriptional
T9406 19200-19205 NN denotes level
T9407 19206-19208 IN denotes by
T9408 19209-19220 JJ denotes competitive
T9409 19221-19232 NN denotes interaction
T9410 19233-19237 IN denotes with
T9411 19238-19241 DT denotes the
T9412 19242-19249 NNP denotes CH1-KIX
T9413 19250-19256 NN denotes domain
T9414 19257-19259 IN denotes of
T9415 19260-19263 NNP denotes CBP
T9416 19264-19266 CC denotes or
T9417 19267-19272 JJ denotes local
T9418 19273-19280 NN denotes histone
T9419 19281-19296 NN denotes hypoacetylation
T9420 19297-19298 NNP denotes [
T9421 19298-19300 CD denotes 25
T9422 19300-19301 NNP denotes ]
T9423 19301-19302 . denotes .
T9424 19303-19306 PDT denotes All
T9425 19307-19312 DT denotes these
T9426 19313-19321 NNS denotes findings
T9427 19322-19330 VBP denotes indicate
T9428 19331-19334 DT denotes the
T9429 19335-19344 JJ denotes potential
T9430 19345-19355 VBP denotes complicate
T9431 19356-19365 NN denotes crosstalk
T9432 19366-19373 IN denotes between
T9433 19374-19379 NNP denotes NF-κB
T9434 19380-19383 CC denotes and
T9435 19384-19388 NNP denotes Nrf2
T9436 19388-19389 , denotes ,
T9437 19390-19395 WDT denotes which
T9438 19396-19399 MD denotes may
T9439 19400-19402 VB denotes be
T9440 19403-19412 VBN denotes regulated
T9441 19413-19415 IN denotes by
T9442 19416-19419 DT denotes the
T9443 19420-19428 JJ denotes upstream
T9444 19429-19446 JJ denotes mitogen-activated
T9445 19447-19454 NN denotes protein
T9446 19455-19461 NN denotes kinase
T9447 19462-19463 -LRB- denotes (
T9448 19463-19468 NNS denotes MAPKs
T9449 19468-19469 -RRB- denotes )
T9450 19470-19477 VBP denotes pathway
T9451 19478-19479 NNP denotes [
T9452 19479-19481 CD denotes 26
T9453 19481-19482 NNP denotes ]
T9454 19482-19483 . denotes .
T9455 19484-19486 PRP denotes It
T9456 19487-19490 VBZ denotes has
T9457 19491-19495 VBN denotes been
T9458 19496-19505 VBN denotes confirmed
T9459 19506-19510 IN denotes that
T9460 19511-19515 NNP denotes Nrf2
T9461 19516-19518 VBZ denotes is
T9462 19519-19525 RB denotes mainly
T9463 19526-19534 VBN denotes detected
T9464 19535-19537 IN denotes in
T9465 19538-19545 NN denotes nucleus
T9466 19546-19548 IN denotes of
T9467 19549-19559 NNS denotes astrocytes
T9468 19560-19565 IN denotes after
T9469 19566-19569 NNP denotes TBI
T9470 19570-19571 NNP denotes [
T9471 19571-19573 CD denotes 18
T9472 19573-19574 NNP denotes ]
T9473 19574-19575 . denotes .
T9474 19576-19578 IN denotes In
T9475 19579-19583 NN denotes view
T9476 19584-19586 IN denotes of
T9477 19587-19590 DT denotes the
T9478 19591-19595 NN denotes fact
T9479 19596-19600 IN denotes that
T9480 19601-19605 NNP denotes Nrf2
T9481 19606-19608 VBZ denotes is
T9482 19609-19610 DT denotes a
T9483 19611-19624 NN denotes transcription
T9484 19625-19631 NN denotes factor
T9485 19632-19637 WDT denotes which
T9486 19638-19644 MD denotes should
T9487 19645-19649 VB denotes take
T9488 19650-19658 NN denotes function
T9489 19659-19665 RB denotes mainly
T9490 19666-19668 IN denotes in
T9491 19669-19676 NN denotes nucleus
T9492 19676-19677 , denotes ,
T9493 19678-19680 PRP denotes it
T9494 19681-19684 MD denotes can
T9495 19685-19687 VB denotes be
T9496 19688-19696 VBN denotes reasoned
T9497 19697-19701 IN denotes that
T9498 19702-19712 NNS denotes astrocytes
T9499 19713-19716 MD denotes may
T9500 19717-19719 VB denotes be
T9501 19720-19723 CD denotes one
T9502 19724-19728 NN denotes kind
T9503 19729-19731 IN denotes of
T9504 19732-19742 NN denotes respondent
T9505 19743-19748 NNS denotes cells
T9506 19749-19751 IN denotes in
T9507 19752-19762 NN denotes activation
T9508 19763-19765 IN denotes of
T9509 19766-19774 JJ denotes Nrf2-ARE
T9510 19775-19782 NN denotes pathway
T9511 19783-19788 IN denotes after
T9512 19789-19792 NNP denotes TBI
T9513 19792-19793 . denotes .
T9514 19794-19802 JJ denotes Previous
T9515 19803-19808 NN denotes study
T9516 19809-19819 VBD denotes identified
T9517 19820-19823 DT denotes the
T9518 19824-19834 NN denotes expression
T9519 19835-19837 IN denotes of
T9520 19838-19843 NNP denotes TNF-α
T9521 19843-19844 , denotes ,
T9522 19845-19850 NNP denotes IL-1β
T9523 19850-19851 , denotes ,
T9524 19852-19855 CC denotes and
T9525 19856-19860 NNP denotes IL-6
T9526 19861-19863 IN denotes in
T9527 19864-19872 JJ denotes cultured
T9528 19873-19883 NNS denotes astrocytes
T9529 19884-19889 IN denotes after
T9530 19890-19899 NN denotes treatment
T9531 19900-19904 IN denotes with
T9532 19905-19908 NNP denotes LPS
T9533 19909-19911 CC denotes or
T9534 19912-19925 VBN denotes oxyhemoglobin
T9535 19926-19927 NNP denotes [
T9536 19927-19929 CD denotes 27
T9537 19929-19930 , denotes ,
T9538 19931-19933 CD denotes 28
T9539 19933-19934 NN denotes ]
T9540 19934-19935 . denotes .
T9541 19936-19943 DT denotes Another
T9542 19944-19949 NN denotes study
T9543 19950-19958 VBD denotes revealed
T9544 19959-19963 IN denotes that
T9545 19964-19969 IN denotes after
T9546 19970-19976 JJ denotes middle
T9547 19977-19985 JJ denotes cerebral
T9548 19986-19992 NN denotes artery
T9549 19993-20002 NN denotes occlusion
T9550 20002-20003 , denotes ,
T9551 20004-20017 JJ denotes MMP9-positive
T9552 20018-20028 NNS denotes astrocytes
T9553 20029-20033 VBD denotes were
T9554 20034-20042 VBN denotes observed
T9555 20043-20045 IN denotes in
T9556 20046-20051 NN denotes brain
T9557 20052-20059 NNS denotes tissues
T9558 20060-20062 IN denotes by
T9559 20063-20083 NN denotes immunohistochemistry
T9560 20084-20085 NNP denotes [
T9561 20085-20087 CD denotes 29
T9562 20087-20088 NNP denotes ]
T9563 20088-20089 . denotes .
T9564 20090-20095 DT denotes Those
T9565 20096-20103 NNS denotes results
T9566 20104-20112 VBP denotes indicate
T9567 20113-20116 DT denotes the
T9568 20117-20121 NN denotes role
T9569 20122-20124 IN denotes of
T9570 20125-20135 NNS denotes astrocytes
T9571 20136-20138 IN denotes in
T9572 20139-20151 JJ denotes inflammatory
T9573 20152-20159 NN denotes process
T9574 20160-20165 IN denotes after
T9575 20166-20171 NN denotes brain
T9576 20172-20178 NN denotes injury
T9577 20178-20179 . denotes .
T9578 20180-20183 CC denotes But
T9579 20184-20188 IN denotes till
T9580 20189-20192 RB denotes now
T9581 20192-20193 , denotes ,
T9582 20194-20199 EX denotes there
T9583 20200-20202 VBZ denotes is
T9584 20203-20205 DT denotes no
T9585 20206-20211 NN denotes study
T9586 20212-20219 VBD denotes focused
T9587 20220-20222 IN denotes on
T9588 20223-20226 DT denotes the
T9589 20227-20239 NN denotes relationship
T9590 20240-20245 IN denotes among
T9591 20246-20256 NNS denotes astrocytes
T9592 20256-20257 , denotes ,
T9593 20258-20262 NNP denotes Nrf2
T9594 20262-20263 , denotes ,
T9595 20264-20267 CC denotes and
T9596 20268-20283 JJ denotes proinflammatory
T9597 20284-20293 NNS denotes mediators
T9598 20294-20299 IN denotes after
T9599 20300-20303 NNP denotes TBI
T9600 20303-20304 . denotes .
T9601 20305-20308 PRP$ denotes Our
T9602 20309-20316 NNS denotes results
T9603 20317-20329 VBD denotes demonstrated
T9604 20330-20333 DT denotes the
T9605 20334-20345 JJ denotes upregulated
T9606 20346-20356 NN denotes expression
T9607 20357-20359 IN denotes of
T9608 20360-20365 NNP denotes TNF-α
T9609 20365-20366 , denotes ,
T9610 20367-20372 NNP denotes IL-1β
T9611 20372-20373 , denotes ,
T9612 20374-20378 NNP denotes IL-6
T9613 20378-20379 , denotes ,
T9614 20380-20383 CC denotes and
T9615 20384-20388 NNP denotes MMP9
T9616 20389-20391 IN denotes in
T9617 20392-20396 NNP denotes Nrf2
T9618 20397-20405 NN denotes knockout
T9619 20406-20416 NNS denotes astrocytes
T9620 20417-20422 IN denotes after
T9621 20423-20430 NN denotes scratch
T9622 20431-20437 NN denotes injury
T9623 20438-20441 IN denotes for
T9624 20442-20445 DT denotes the
T9625 20446-20451 JJ denotes first
T9626 20452-20456 NN denotes time
T9627 20456-20457 . denotes .
T9628 20458-20460 IN denotes In
T9629 20461-20471 NN denotes conclusion
T9630 20471-20472 , denotes ,
T9631 20473-20482 NN denotes depletion
T9632 20483-20485 IN denotes of
T9633 20486-20490 JJ denotes Nrf2
T9634 20491-20498 VBD denotes induced
T9635 20499-20502 DT denotes the
T9636 20503-20513 NN denotes activation
T9637 20514-20516 IN denotes of
T9638 20517-20522 NNP denotes NF-κB
T9639 20523-20526 CC denotes and
T9640 20527-20530 DT denotes the
T9641 20531-20541 NN denotes expression
T9642 20542-20544 IN denotes of
T9643 20545-20550 NNP denotes TNF-α
T9644 20550-20551 , denotes ,
T9645 20552-20557 NNP denotes IL-1β
T9646 20557-20558 , denotes ,
T9647 20559-20563 NNP denotes IL-6
T9648 20563-20564 , denotes ,
T9649 20565-20568 CC denotes and
T9650 20569-20573 NNP denotes MMP9
T9651 20574-20583 VBG denotes resulting
T9652 20584-20586 IN denotes in
T9653 20587-20591 JJR denotes more
T9654 20592-20596 NN denotes cell
T9655 20597-20603 NNS denotes deaths
T9656 20604-20606 IN denotes in
T9657 20607-20617 NNS denotes astrocytes
T9658 20618-20623 IN denotes after
T9659 20624-20631 NN denotes scratch
T9660 20632-20638 NN denotes injury
T9661 20638-20639 . denotes .
T9662 20640-20645 DT denotes These
T9663 20646-20653 NNS denotes results
T9664 20654-20661 VBP denotes suggest
T9665 20662-20666 IN denotes that
T9666 20667-20671 NNP denotes Nrf2
T9667 20672-20675 MD denotes may
T9668 20676-20678 VB denotes be
T9669 20679-20681 DT denotes an
T9670 20682-20691 JJ denotes important
T9671 20692-20698 NN denotes target
T9672 20699-20702 IN denotes for
T9673 20703-20720 JJ denotes anti-inflammatory
T9674 20721-20728 NN denotes therapy
T9675 20729-20734 IN denotes after
T9676 20735-20738 NNP denotes TBI
T9677 20738-20739 . denotes .
R1247 T1507 T1507 ROOT 2.1,2.1
R1248 T1508 T1507 punct .,2.1
R1249 T1509 T1510 amod Primary,Culture
R1250 T1510 T1522 nsubjpass Culture,provided
R1251 T1511 T1510 cc and,Culture
R1252 T1512 T1510 conj Identification,Culture
R1253 T1513 T1510 prep of,Culture
R1254 T1514 T1516 compound Mouse,Nrf2
R1255 T1515 T1516 compound Astrocytes,Nrf2
R1256 T1516 T1518 compound Nrf2,ICR
R1257 T1517 T1518 compound knockout,ICR
R1258 T1518 T1519 compound ICR,mice
R1259 T1519 T1513 pobj mice,of
R1260 T1520 T1522 auxpass were,provided
R1261 T1521 T1522 advmod kindly,provided
R1262 T1522 T1522 ROOT provided,provided
R1263 T1523 T1522 agent by,provided
R1264 T1524 T1527 compound Dr.,Kensler
R1265 T1525 T1527 compound Thomas,Kensler
R1266 T1526 T1527 compound W.,Kensler
R1267 T1527 T1523 pobj Kensler,by
R1268 T1528 T1527 punct (,Kensler
R1269 T1529 T1530 compound Johns,Hopkins
R1270 T1530 T1531 compound Hopkins,University
R1271 T1531 T1527 appos University,Kensler
R1272 T1532 T1531 punct ",",University
R1273 T1533 T1531 conj Baltimore,University
R1274 T1534 T1533 punct ",",Baltimore
R1275 T1535 T1533 conj MD,Baltimore
R1276 T1536 T1535 punct ",",MD
R1277 T1537 T1535 conj USA,MD
R1278 T1538 T1527 punct ),Kensler
R1279 T1539 T1522 punct .,provided
R1280 T1540 T1541 amod Primary,astrocytes
R1281 T1541 T1543 nsubjpass astrocytes,obtained
R1282 T1542 T1543 auxpass were,obtained
R1283 T1543 T1543 ROOT obtained,obtained
R1284 T1544 T1543 prep from,obtained
R1285 T1545 T1549 amod postnatal,type
R1286 T1546 T1549 amod 2-day-old,type
R1287 T1547 T1549 amod Nrf2,type
R1288 T1548 T1549 amod wide,type
R1289 T1549 T1558 nmod type,mice
R1290 T1550 T1549 punct (,type
R1291 T1551 T1549 appos WT,type
R1292 T1552 T1551 punct ),WT
R1293 T1553 T1549 cc and,type
R1294 T1554 T1549 conj knockout,type
R1295 T1555 T1556 punct (,KO
R1296 T1556 T1554 appos KO,knockout
R1297 T1557 T1554 punct ),knockout
R1298 T1558 T1544 pobj mice,from
R1299 T1559 T1558 punct (,mice
R1300 T1560 T1561 nummod 6,mice
R1301 T1561 T1558 appos mice,mice
R1302 T1562 T1561 prep for,mice
R1303 T1563 T1564 det each,genotype
R1304 T1564 T1562 pobj genotype,for
R1305 T1565 T1558 punct ),mice
R1306 T1566 T1543 punct .,obtained
R1307 T1567 T1573 prep Following,dissected
R1308 T1568 T1567 pobj decapitation,Following
R1309 T1569 T1573 punct ",",dissected
R1310 T1570 T1571 det the,cortices
R1311 T1571 T1573 nsubjpass cortices,dissected
R1312 T1572 T1573 auxpass were,dissected
R1313 T1573 T1573 ROOT dissected,dissected
R1314 T1574 T1573 prt out,dissected
R1315 T1575 T1573 punct ",",dissected
R1316 T1576 T1573 cc and,dissected
R1317 T1577 T1578 det the,meninges
R1318 T1578 T1580 nsubj meninges,associated
R1319 T1579 T1578 cc and,meninges
R1320 T1580 T1582 amod associated,vessels
R1321 T1581 T1582 compound blood,vessels
R1322 T1582 T1584 nsubjpass vessels,removed
R1323 T1583 T1584 auxpass were,removed
R1324 T1584 T1573 conj removed,dissected
R1325 T1585 T1584 punct .,removed
R1326 T1586 T1587 det The,tissue
R1327 T1587 T1590 nsubjpass tissue,chopped
R1328 T1588 T1590 auxpass was,chopped
R1329 T1589 T1590 advmod roughly,chopped
R1330 T1590 T1590 ROOT chopped,chopped
R1331 T1591 T1590 prep with,chopped
R1332 T1592 T1594 det a,blade
R1333 T1593 T1594 compound scalpel,blade
R1334 T1594 T1591 pobj blade,with
R1335 T1595 T1590 punct ",",chopped
R1336 T1596 T1590 conj incubated,chopped
R1337 T1597 T1596 prep in,incubated
R1338 T1598 T1599 nummod 0.5,%
R1339 T1599 T1600 compound %,trypsin
R1340 T1600 T1597 pobj trypsin,in
R1341 T1601 T1596 prep for,incubated
R1342 T1602 T1603 nummod 10,minutes
R1343 T1603 T1601 pobj minutes,for
R1344 T1604 T1596 prep at,incubated
R1345 T1605 T1606 nummod 37,°
R1346 T1606 T1607 nummod °,C
R1347 T1607 T1604 pobj C,at
R1348 T1608 T1596 punct ",",incubated
R1349 T1609 T1596 cc and,incubated
R1350 T1610 T1596 conj agitated,incubated
R1351 T1611 T1613 det every,minutes
R1352 T1612 T1613 amod few,minutes
R1353 T1613 T1590 npadvmod minutes,chopped
R1354 T1614 T1590 punct .,chopped
R1355 T1615 T1621 prep After,rinsed
R1356 T1616 T1615 pobj digestion,After
R1357 T1617 T1621 punct ",",rinsed
R1358 T1618 T1619 det the,tissue
R1359 T1619 T1621 nsubjpass tissue,rinsed
R1360 T1620 T1621 auxpass was,rinsed
R1361 T1621 T1621 ROOT rinsed,rinsed
R1362 T1622 T1621 advmod twice,rinsed
R1363 T1623 T1621 prep in,rinsed
R1364 T1624 T1623 pobj DMEM,in
R1365 T1625 T1621 prep with,rinsed
R1366 T1626 T1627 nummod 10,%
R1367 T1627 T1628 compound %,FBS
R1368 T1628 T1625 pobj FBS,with
R1369 T1629 T1628 punct ",",FBS
R1370 T1630 T1628 acl followed,FBS
R1371 T1631 T1630 agent by,followed
R1372 T1632 T1634 det a,dissociation
R1373 T1633 T1634 amod mechanical,dissociation
R1374 T1634 T1631 pobj dissociation,by
R1375 T1635 T1634 prep in,dissociation
R1376 T1636 T1635 pobj DMEM,in
R1377 T1637 T1634 prep with,dissociation
R1378 T1638 T1639 nummod 20,%
R1379 T1639 T1640 compound %,FBS
R1380 T1640 T1637 pobj FBS,with
R1381 T1641 T1640 cc and,FBS
R1382 T1642 T1644 nummod 5,penicillin
R1383 T1643 T1644 amod units/mL,penicillin
R1384 T1644 T1640 conj penicillin,FBS
R1385 T1645 T1644 punct ",",penicillin
R1386 T1646 T1647 nummod 5,μg
R1387 T1647 T1648 compound μg,/
R1388 T1648 T1650 compound /,streptomycin
R1389 T1649 T1650 compound mL,streptomycin
R1390 T1650 T1644 appos streptomycin,penicillin
R1391 T1651 T1654 punct (,medium
R1392 T1652 T1654 amod complete,medium
R1393 T1653 T1654 compound culture,medium
R1394 T1654 T1650 appos medium,streptomycin
R1395 T1655 T1650 punct ),streptomycin
R1396 T1656 T1621 punct .,rinsed
R1397 T1657 T1666 prep After,transferred
R1398 T1658 T1657 pobj incubation,After
R1399 T1659 T1658 prep for,incubation
R1400 T1660 T1661 nummod 1,h
R1401 T1661 T1659 pobj h,for
R1402 T1662 T1666 punct ",",transferred
R1403 T1663 T1664 det the,supernatant
R1404 T1664 T1666 nsubjpass supernatant,transferred
R1405 T1665 T1666 auxpass was,transferred
R1406 T1666 T1666 ROOT transferred,transferred
R1407 T1667 T1666 prep to,transferred
R1408 T1668 T1670 det a,flask
R1409 T1669 T1670 amod new,flask
R1410 T1670 T1667 pobj flask,to
R1411 T1671 T1670 cc or,flask
R1412 T1672 T1670 conj dish,flask
R1413 T1673 T1674 punct (,Costar
R1414 T1674 T1670 appos Costar,flask
R1415 T1675 T1674 punct ",",Costar
R1416 T1676 T1674 appos USA,Costar
R1417 T1677 T1674 punct ),Costar
R1418 T1678 T1666 prep for,transferred
R1419 T1679 T1678 pcomp depleting,for
R1420 T1680 T1683 det the,cells
R1421 T1681 T1683 amod residual,cells
R1422 T1682 T1683 amod epithelial,cells
R1423 T1683 T1679 dobj cells,depleting
R1424 T1684 T1666 punct .,transferred
R1425 T1685 T1689 advmod Then,cultivated
R1426 T1686 T1687 det the,cells
R1427 T1687 T1689 nsubjpass cells,cultivated
R1428 T1688 T1689 auxpass were,cultivated
R1429 T1689 T1689 ROOT cultivated,cultivated
R1430 T1690 T1689 prep at,cultivated
R1431 T1691 T1692 nummod 37,°
R1432 T1692 T1690 pobj °,at
R1433 T1693 T1689 npadvmod C,cultivated
R1434 T1694 T1689 prep with,cultivated
R1435 T1695 T1696 nummod 5,%
R1436 T1696 T1697 compound %,CO2
R1437 T1697 T1694 pobj CO2,with
R1438 T1698 T1689 punct .,cultivated
R1439 T1699 T1704 cc And,was
R1440 T1700 T1703 det the,medium
R1441 T1701 T1703 amod complete,medium
R1442 T1702 T1703 compound culture,medium
R1443 T1703 T1704 nsubj medium,was
R1444 T1704 T1704 ROOT was,was
R1445 T1705 T1704 acomp half-changed,was
R1446 T1706 T1704 advmod twice,was
R1447 T1707 T1708 det a,week
R1448 T1708 T1706 npadvmod week,twice
R1449 T1709 T1704 punct .,was
R1450 T1710 T1711 nsubj Astrocytes,expanded
R1451 T1711 T1711 ROOT expanded,expanded
R1452 T1712 T1711 prep for,expanded
R1453 T1713 T1714 advmod about,7
R1454 T1714 T1715 nummod 7,days
R1455 T1715 T1712 pobj days,for
R1456 T1716 T1717 aux to,reach
R1457 T1717 T1711 advcl reach,expanded
R1458 T1718 T1717 dobj confluence,reach
R1459 T1719 T1711 punct .,expanded
R1460 T1720 T1726 advmod Then,shaken
R1461 T1721 T1722 det the,flasks
R1462 T1722 T1726 nsubjpass flasks,shaken
R1463 T1723 T1722 cc or,flasks
R1464 T1724 T1722 conj dishes,flasks
R1465 T1725 T1726 auxpass were,shaken
R1466 T1726 T1726 ROOT shaken,shaken
R1467 T1727 T1726 prep at,shaken
R1468 T1728 T1729 nummod 150,rpm
R1469 T1729 T1727 pobj rpm,at
R1470 T1730 T1726 prep for,shaken
R1471 T1731 T1732 nummod 4,h
R1472 T1732 T1730 pobj h,for
R1473 T1733 T1734 aux to,deplete
R1474 T1734 T1726 advcl deplete,shaken
R1475 T1735 T1736 det the,microglia
R1476 T1736 T1734 dobj microglia,deplete
R1477 T1737 T1736 cc and,microglia
R1478 T1738 T1739 advmod less,adherent
R1479 T1739 T1740 amod adherent,cells
R1480 T1740 T1736 conj cells,microglia
R1481 T1741 T1734 prep from,deplete
R1482 T1742 T1743 det the,cultures
R1483 T1743 T1741 pobj cultures,from
R1484 T1744 T1726 punct .,shaken
R1485 T1745 T1751 prep After,were
R1486 T1746 T1745 pcomp shaking,After
R1487 T1747 T1751 punct ",",were
R1488 T1748 T1750 det the,cultures
R1489 T1749 T1750 amod resulting,cultures
R1490 T1750 T1751 nsubj cultures,were
R1491 T1751 T1751 ROOT were,were
R1492 T1752 T1753 advmod mainly,astrocytes
R1493 T1753 T1751 attr astrocytes,were
R1494 T1754 T1753 punct ",",astrocytes
R1495 T1755 T1757 nsubjpass which,determined
R1496 T1756 T1757 auxpass were,determined
R1497 T1757 T1753 relcl determined,astrocytes
R1498 T1758 T1757 agent by,determined
R1499 T1759 T1758 pobj immunoreactivity,by
R1500 T1760 T1757 prep for,determined
R1501 T1761 T1760 pobj GFAP,for
R1502 T1762 T1767 punct (,Biotechnology
R1503 T1763 T1767 amod sc-166481,Biotechnology
R1504 T1764 T1767 punct ",",Biotechnology
R1505 T1765 T1766 compound Santa,Cruz
R1506 T1766 T1767 compound Cruz,Biotechnology
R1507 T1767 T1761 appos Biotechnology,GFAP
R1508 T1768 T1767 punct ",",Biotechnology
R1509 T1769 T1767 conj CA,Biotechnology
R1510 T1770 T1769 punct ",",CA
R1511 T1771 T1767 meta USA,Biotechnology
R1512 T1772 T1767 punct ),Biotechnology
R1513 T1773 T1751 punct .,were
R1514 T1774 T1775 nsubj Cells,passaged
R1515 T1775 T1775 ROOT passaged,passaged
R1516 T1776 T1775 prep for,passaged
R1517 T1777 T1778 nummod 2-3,generations
R1518 T1778 T1776 pobj generations,for
R1519 T1779 T1780 auxpass were,used
R1520 T1780 T1775 conj used,passaged
R1521 T1781 T1780 prep in,used
R1522 T1782 T1784 det the,studies
R1523 T1783 T1784 amod following,studies
R1524 T1784 T1781 pobj studies,in
R1525 T1785 T1775 punct .,passaged
R1623 T1921 T1921 ROOT 2.2,2.2
R1624 T1922 T1921 punct .,2.2
R1625 T1923 T1936 prep In,performed
R1626 T1924 T1925 compound Vitro,Model
R1627 T1925 T1923 pobj Model,In
R1628 T1926 T1925 prep of,Model
R1629 T1927 T1926 pobj TBI,of
R1630 T1928 T1936 nsubjpass Established,performed
R1631 T1929 T1928 agent by,Established
R1632 T1930 T1934 compound Scratch,injury
R1633 T1931 T1932 compound Injury,Astrocyte
R1634 T1932 T1934 compound Astrocyte,injury
R1635 T1933 T1934 compound scratch,injury
R1636 T1934 T1929 pobj injury,by
R1637 T1935 T1936 auxpass was,performed
R1638 T1936 T1936 ROOT performed,performed
R1639 T1937 T1936 prep as,performed
R1640 T1938 T1937 prep in,as
R1641 T1939 T1941 det a,report
R1642 T1940 T1941 amod previous,report
R1643 T1941 T1938 pobj report,in
R1644 T1942 T1937 pobj [,as
R1645 T1943 T1942 nummod 7,[
R1646 T1944 T1942 conj ],[
R1647 T1945 T1936 punct .,performed
R1648 T1946 T1948 nsubjpass Astrocytes,planted
R1649 T1947 T1948 auxpass were,planted
R1650 T1948 T1948 ROOT planted,planted
R1651 T1949 T1948 prep in,planted
R1652 T1950 T1951 amod 6-well,plates
R1653 T1951 T1949 pobj plates,in
R1654 T1952 T1948 cc and,planted
R1655 T1953 T1948 conj grown,planted
R1656 T1954 T1953 prep to,grown
R1657 T1955 T1954 pobj confluence,to
R1658 T1956 T1948 punct .,planted
R1659 T1957 T1959 det The,monolayer
R1660 T1958 T1959 compound cell,monolayer
R1661 T1959 T1961 nsubjpass monolayer,scratched
R1662 T1960 T1961 auxpass was,scratched
R1663 T1961 T1961 ROOT scratched,scratched
R1664 T1962 T1961 prep with,scratched
R1665 T1963 T1967 det a,needle
R1666 T1964 T1967 amod sterile,needle
R1667 T1965 T1967 compound 26G,needle
R1668 T1966 T1967 compound syringe,needle
R1669 T1967 T1962 pobj needle,with
R1670 T1968 T1961 punct ",",scratched
R1671 T1969 T1961 advcl resulting,scratched
R1672 T1970 T1969 prep in,resulting
R1673 T1971 T1972 det the,formation
R1674 T1972 T1970 pobj formation,in
R1675 T1973 T1972 prep of,formation
R1676 T1974 T1978 det a,gap
R1677 T1975 T1976 nummod 0.5,mm
R1678 T1976 T1978 nmod mm,gap
R1679 T1977 T1978 amod wide,gap
R1680 T1978 T1973 pobj gap,of
R1681 T1979 T1961 punct .,scratched
R1682 T1980 T1981 advmod Immediately,after
R1683 T1981 T1986 prep after,washed
R1684 T1982 T1981 pobj scratch,after
R1685 T1983 T1986 punct ",",washed
R1686 T1984 T1986 nsubjpass cells,washed
R1687 T1985 T1986 auxpass were,washed
R1688 T1986 T1986 ROOT washed,washed
R1689 T1987 T1986 advmod twice,washed
R1690 T1988 T1986 prep with,washed
R1691 T1989 T1990 amod sterile,PBS
R1692 T1990 T1988 pobj PBS,with
R1693 T1991 T1986 punct ",",washed
R1694 T1992 T1986 conj cultured,washed
R1695 T1993 T1992 prep with,cultured
R1696 T1994 T1996 amod complete,medium
R1697 T1995 T1996 compound culture,medium
R1698 T1996 T1993 pobj medium,with
R1699 T1997 T1992 punct ",",cultured
R1700 T1998 T1992 cc and,cultured
R1701 T1999 T1992 conj named,cultured
R1702 T2000 T1999 prep as,named
R1703 T2001 T2002 compound TBI,group
R1704 T2002 T2000 pobj group,as
R1705 T2003 T1986 punct .,washed
R1706 T2004 T2013 nsubjpass Cells,used
R1707 T2005 T2004 punct ",",Cells
R1708 T2006 T2009 nsubjpass which,received
R1709 T2007 T2009 aux did,received
R1710 T2008 T2009 neg not,received
R1711 T2009 T2004 relcl received,Cells
R1712 T2010 T2009 dobj scratch,received
R1713 T2011 T2013 punct ",",used
R1714 T2012 T2013 auxpass were,used
R1715 T2013 T2013 ROOT used,used
R1716 T2014 T2013 prep as,used
R1717 T2015 T2016 amod blank,control
R1718 T2016 T2014 pobj control,as
R1719 T2017 T2013 cc and,used
R1720 T2018 T2013 conj named,used
R1721 T2019 T2018 prep as,named
R1722 T2020 T2021 amod sham,group
R1723 T2021 T2019 pobj group,as
R1724 T2022 T2013 punct .,used
R1844 T2171 T2171 ROOT 2.3,2.3
R1845 T2172 T2171 punct .,2.3
R1846 T2173 T2175 compound Cell,Measurement
R1847 T2174 T2175 compound Death,Measurement
R1848 T2175 T2184 nsubjpass Measurement,seeded
R1849 T2176 T2175 prep by,Measurement
R1850 T2177 T2178 compound CCK-8,Assay
R1851 T2178 T2176 pobj Assay,by
R1852 T2179 T2180 nummod 1,×
R1853 T2180 T2182 nummod ×,cells
R1854 T2181 T2182 amod 103/well,cells
R1855 T2182 T2184 nsubjpass cells,seeded
R1856 T2183 T2184 auxpass were,seeded
R1857 T2184 T2184 ROOT seeded,seeded
R1858 T2185 T2195 aux to,adhere
R1859 T2186 T2195 advmod 96-well,adhere
R1860 T2187 T2188 compound culture,plates
R1861 T2188 T2186 dobj plates,96-well
R1862 T2189 T2186 cc and,96-well
R1863 T2190 T2186 conj cultivated,96-well
R1864 T2191 T2195 mark for,adhere
R1865 T2192 T2193 nummod 24,h
R1866 T2193 T2195 nsubj h,adhere
R1867 T2194 T2195 aux to,adhere
R1868 T2195 T2184 xcomp adhere,seeded
R1869 T2196 T2184 punct .,seeded
R1870 T2197 T2201 advmod Then,scrated
R1871 T2198 T2199 det the,cell
R1872 T2199 T2201 nsubjpass cell,scrated
R1873 T2200 T2201 auxpass was,scrated
R1874 T2201 T2201 ROOT scrated,scrated
R1875 T2202 T2203 mark as,mentioned
R1876 T2203 T2201 advcl mentioned,scrated
R1877 T2204 T2203 advmod above,mentioned
R1878 T2205 T2201 punct .,scrated
R1879 T2206 T2208 compound Astrocyte,death
R1880 T2207 T2208 compound cell,death
R1881 T2208 T2210 nsubjpass death,assessed
R1882 T2209 T2210 auxpass was,assessed
R1883 T2210 T2210 ROOT assessed,assessed
R1884 T2211 T2210 agent by,assessed
R1885 T2212 T2211 pobj cell,by
R1886 T2213 T2210 advcl counting,assessed
R1887 T2214 T2216 nmod kit-8,CCK-8
R1888 T2215 T2216 punct (,CCK-8
R1889 T2216 T2223 nmod CCK-8,assay
R1890 T2217 T2216 punct ),CCK-8
R1891 T2218 T2223 punct (,assay
R1892 T2219 T2223 nmod Dojindo,assay
R1893 T2220 T2219 punct ",",Dojindo
R1894 T2221 T2223 nmod Japan,assay
R1895 T2222 T2223 punct ),assay
R1896 T2223 T2228 nsubj assay,according
R1897 T2224 T2225 nummod 24,h
R1898 T2225 T2226 npadvmod h,after
R1899 T2226 T2223 prep after,assay
R1900 T2227 T2226 pobj scratch,after
R1901 T2228 T2210 prep according,assessed
R1902 T2229 T2228 prep to,according
R1903 T2230 T2231 det the,manufacturer
R1904 T2231 T2233 poss manufacturer,protocol
R1905 T2232 T2231 case 's,manufacturer
R1906 T2233 T2229 pobj protocol,to
R1907 T2234 T2210 punct .,assessed
R1908 T2235 T2241 advmod Briefly,added
R1909 T2236 T2241 punct ",",added
R1910 T2237 T2239 nummod 10,CCK-8
R1911 T2238 T2239 compound μL,CCK-8
R1912 T2239 T2241 nsubjpass CCK-8,added
R1913 T2240 T2241 auxpass was,added
R1914 T2241 T2241 ROOT added,added
R1915 T2242 T2241 prep into,added
R1916 T2243 T2244 det every,well
R1917 T2244 T2242 pobj well,into
R1918 T2245 T2241 cc and,added
R1919 T2246 T2241 conj incubated,added
R1920 T2247 T2246 prep for,incubated
R1921 T2248 T2249 nummod 1,h
R1922 T2249 T2247 pobj h,for
R1923 T2250 T2241 punct .,added
R1924 T2251 T2255 advmod Then,read
R1925 T2252 T2253 compound OD,value
R1926 T2253 T2255 nsubjpass value,read
R1927 T2254 T2255 auxpass was,read
R1928 T2255 T2255 ROOT read,read
R1929 T2256 T2255 prep at,read
R1930 T2257 T2258 nummod 450,nm
R1931 T2258 T2256 pobj nm,at
R1932 T2259 T2255 advcl using,read
R1933 T2260 T2264 det a,reader
R1934 T2261 T2264 compound Bio-Rad,reader
R1935 T2262 T2264 compound ELISA,reader
R1936 T2263 T2264 compound microplate,reader
R1937 T2264 T2259 dobj reader,using
R1938 T2265 T2267 punct (,Laboratories
R1939 T2266 T2267 compound Bio-Rad,Laboratories
R1940 T2267 T2264 appos Laboratories,reader
R1941 T2268 T2267 punct ",",Laboratories
R1942 T2269 T2267 conj CA,Laboratories
R1943 T2270 T2269 punct ",",CA
R1944 T2271 T2269 conj USA,CA
R1945 T2272 T2267 punct ),Laboratories
R1946 T2273 T2255 punct .,read
R1947 T2274 T2275 det All,measurements
R1948 T2275 T2277 nsubjpass measurements,performed
R1949 T2276 T2277 auxpass were,performed
R1950 T2277 T2277 ROOT performed,performed
R1951 T2278 T2277 prep in,performed
R1952 T2279 T2278 pobj sextuplicate,in
R1953 T2280 T2277 punct .,performed
R1954 T2281 T2283 nsubjpass Results,expressed
R1955 T2282 T2283 auxpass were,expressed
R1956 T2283 T2283 ROOT expressed,expressed
R1957 T2284 T2283 prep as,expressed
R1958 T2285 T2284 pobj mean,as
R1959 T2286 T2285 prep of,mean
R1960 T2287 T2288 compound OD,value
R1961 T2288 T2286 pobj value,of
R1962 T2289 T2283 prep at,expressed
R1963 T2290 T2292 nummod 450,±
R1964 T2291 T2292 compound nm,±
R1965 T2292 T2293 compound ±,SD
R1966 T2293 T2289 pobj SD,at
R1967 T2294 T2283 punct .,expressed
R217 T315 T316 det The,Absence
R218 T316 T333 nsubj Absence,proved
R219 T317 T316 prep of,Absence
R220 T318 T319 compound Nrf2,Enhances
R221 T319 T317 pobj Enhances,of
R222 T320 T321 compound NF-κB-Dependent,Inflammation
R223 T321 T316 appos Inflammation,Absence
R224 T322 T333 prep following,proved
R225 T323 T324 compound Scratch,Injury
R226 T324 T322 dobj Injury,following
R227 T325 T324 prep in,Injury
R228 T326 T329 compound Mouse,Astrocytes
R229 T327 T328 compound Primary,Cultured
R230 T328 T329 compound Cultured,Astrocytes
R231 T329 T325 pobj Astrocytes,in
R2313 T2674 T2674 ROOT 2.4,2.4
R2314 T2675 T2674 punct .,2.4
R2315 T2676 T2679 compound Electrophoretic,Assay
R2316 T2677 T2678 compound Mobility,Shift
R2317 T2678 T2679 compound Shift,Assay
R2318 T2679 T2687 nsubjpass Assay,washed
R2319 T2680 T2681 punct (,EMSA
R232 T330 T333 nsubjpass It,proved
R2320 T2681 T2679 appos EMSA,Assay
R2321 T2682 T2681 punct ),EMSA
R2322 T2683 T2679 appos Monolayers,Assay
R2323 T2684 T2683 prep of,Monolayers
R2324 T2685 T2684 pobj astrocytes,of
R2325 T2686 T2687 auxpass were,washed
R2326 T2687 T2687 ROOT washed,washed
R2327 T2688 T2687 prep with,washed
R2328 T2689 T2688 pobj PBS,with
R2329 T2690 T2687 cc and,washed
R233 T331 T333 aux has,proved
R2330 T2691 T2687 conj harvested,washed
R2331 T2692 T2691 prep by,harvested
R2332 T2693 T2692 pcomp scraping,by
R2333 T2694 T2693 prep into,scraping
R2334 T2695 T2696 amod cold,PBS
R2335 T2696 T2694 pobj PBS,into
R2336 T2697 T2687 punct .,washed
R2337 T2698 T2700 det The,pellet
R2338 T2699 T2700 compound cell,pellet
R2339 T2700 T2704 nsubj pellet,was
R234 T332 T333 auxpass been,proved
R2340 T2701 T2700 acl obtained,pellet
R2341 T2702 T2701 agent by,obtained
R2342 T2703 T2702 pobj centrifugation,by
R2343 T2704 T2705 auxpass was,resuspended
R2344 T2705 T2705 ROOT resuspended,resuspended
R2345 T2706 T2705 prep in,resuspended
R2346 T2707 T2706 pobj buffer,in
R2347 T2708 T2707 acl containing,buffer
R2348 T2709 T2711 nummod 10,HEPES
R2349 T2710 T2711 compound mM,HEPES
R235 T333 T333 ROOT proved,proved
R2350 T2711 T2708 dobj HEPES,containing
R2351 T2712 T2713 punct (,pH
R2352 T2713 T2711 appos pH,HEPES
R2353 T2714 T2713 nummod 7.9,pH
R2354 T2715 T2713 punct ),pH
R2355 T2716 T2711 punct ",",HEPES
R2356 T2717 T2719 nummod 10,KCl
R2357 T2718 T2719 compound mM,KCl
R2358 T2719 T2711 conj KCl,HEPES
R2359 T2720 T2719 punct ",",KCl
R236 T334 T337 mark that,enhances
R2360 T2721 T2723 compound 0.1,EDTA
R2361 T2722 T2723 compound mM,EDTA
R2362 T2723 T2719 conj EDTA,KCl
R2363 T2724 T2723 punct ",",EDTA
R2364 T2725 T2727 nummod 0.1,EGTA
R2365 T2726 T2727 compound mM,EGTA
R2366 T2727 T2723 conj EGTA,EDTA
R2367 T2728 T2727 punct ",",EGTA
R2368 T2729 T2731 nummod 1.0,DTT
R2369 T2730 T2731 compound mM,DTT
R237 T335 T336 amod Nrf2,depletion
R2370 T2731 T2727 conj DTT,EGTA
R2371 T2732 T2731 punct ",",DTT
R2372 T2733 T2731 cc and,DTT
R2373 T2734 T2737 nummod 0.5,fluoride
R2374 T2735 T2737 nmod mM,fluoride
R2375 T2736 T2737 compound phenylmethylsulfonyl,fluoride
R2376 T2737 T2731 conj fluoride,DTT
R2377 T2738 T2705 punct .,resuspended
R2378 T2739 T2745 advmod Then,added
R2379 T2740 T2741 nummod 10,%
R238 T336 T337 nsubj depletion,enhances
R2380 T2741 T2743 compound %,P-40
R2381 T2742 T2743 compound Nonidet,P-40
R2382 T2743 T2745 nsubjpass P-40,added
R2383 T2744 T2745 auxpass was,added
R2384 T2745 T2745 ROOT added,added
R2385 T2746 T2745 cc and,added
R2386 T2747 T2745 conj vortexed,added
R2387 T2748 T2747 advmod briefly,vortexed
R2388 T2749 T2747 punct ",",vortexed
R2389 T2750 T2747 cc and,vortexed
R239 T337 T333 ccomp enhances,proved
R2390 T2751 T2752 det the,nuclei
R2391 T2752 T2754 nsubjpass nuclei,pelleted
R2392 T2753 T2754 auxpass were,pelleted
R2393 T2754 T2747 conj pelleted,vortexed
R2394 T2755 T2754 agent by,pelleted
R2395 T2756 T2755 pobj centrifugation,by
R2396 T2757 T2754 punct .,pelleted
R2397 T2758 T2760 det The,proteins
R2398 T2759 T2760 amod nuclear,proteins
R2399 T2760 T2762 nsubjpass proteins,extracted
R240 T338 T339 amod inflammatory,process
R2400 T2761 T2762 auxpass were,extracted
R2401 T2762 T2762 ROOT extracted,extracted
R2402 T2763 T2762 prep with,extracted
R2403 T2764 T2763 pobj buffer,with
R2404 T2765 T2764 acl containing,buffer
R2405 T2766 T2768 nummod 20,HEPES
R2406 T2767 T2768 compound mM,HEPES
R2407 T2768 T2765 dobj HEPES,containing
R2408 T2769 T2770 punct (,pH
R2409 T2770 T2768 appos pH,HEPES
R241 T339 T337 dobj process,enhances
R2410 T2771 T2770 nummod 7.9,pH
R2411 T2772 T2770 punct ),pH
R2412 T2773 T2768 punct ",",HEPES
R2413 T2774 T2776 nummod 0.4,NaCl
R2414 T2775 T2776 compound mM,NaCl
R2415 T2776 T2768 appos NaCl,HEPES
R2416 T2777 T2776 punct ",",NaCl
R2417 T2778 T2780 nummod 1.0,EDTA
R2418 T2779 T2780 compound mM,EDTA
R2419 T2780 T2776 conj EDTA,NaCl
R242 T340 T337 prep through,enhances
R2420 T2781 T2780 punct ",",EDTA
R2421 T2782 T2784 nummod 1.0,EGTA
R2422 T2783 T2784 compound mM,EGTA
R2423 T2784 T2780 conj EGTA,EDTA
R2424 T2785 T2784 punct ",",EGTA
R2425 T2786 T2788 nummod 1.0,DTT
R2426 T2787 T2788 compound mM,DTT
R2427 T2788 T2784 conj DTT,EGTA
R2428 T2789 T2788 punct ",",DTT
R2429 T2790 T2788 cc and,DTT
R243 T341 T340 pobj activation,through
R2430 T2791 T2794 nummod 1.0,fluoride
R2431 T2792 T2794 compound mM,fluoride
R2432 T2793 T2794 compound phenylmethylsulfonyl,fluoride
R2433 T2794 T2788 conj fluoride,DTT
R2434 T2795 T2762 punct .,extracted
R2435 T2796 T2797 amod Insoluble,material
R2436 T2797 T2799 nsubjpass material,removed
R2437 T2798 T2799 auxpass was,removed
R2438 T2799 T2799 ROOT removed,removed
R2439 T2800 T2799 agent by,removed
R244 T342 T341 prep of,activation
R2440 T2801 T2800 pobj centrifugation,by
R2441 T2802 T2799 prep at,removed
R2442 T2803 T2804 nummod 14000,rpm
R2443 T2804 T2802 pobj rpm,at
R2444 T2805 T2799 punct ",",removed
R2445 T2806 T2799 cc and,removed
R2446 T2807 T2808 det the,supernatant
R2447 T2808 T2814 nsubjpass supernatant,stored
R2448 T2809 T2808 acl containing,supernatant
R2449 T2810 T2812 det the,proteins
R245 T343 T342 pobj NF-κB,of
R2450 T2811 T2812 amod nuclear,proteins
R2451 T2812 T2809 dobj proteins,containing
R2452 T2813 T2814 auxpass was,stored
R2453 T2814 T2799 conj stored,removed
R2454 T2815 T2814 prep at,stored
R2455 T2816 T2818 nummod 80,C
R2456 T2817 T2818 nummod °,C
R2457 T2818 T2815 pobj C,at
R2458 T2819 T2814 prep until,stored
R2459 T2820 T2819 pobj use,until
R246 T344 T341 prep in,activation
R2460 T2821 T2814 punct .,stored
R2461 T2822 T2823 compound Protein,concentration
R2462 T2823 T2825 nsubjpass concentration,determined
R2463 T2824 T2825 auxpass was,determined
R2464 T2825 T2825 ROOT determined,determined
R2465 T2826 T2825 advcl using,determined
R2466 T2827 T2831 det a,kit
R2467 T2828 T2831 amod bicinchoninic,kit
R2468 T2829 T2830 compound acid,assay
R2469 T2830 T2831 compound assay,kit
R247 T345 T346 det the,brain
R2470 T2831 T2826 dobj kit,using
R2471 T2832 T2831 prep with,kit
R2472 T2833 T2834 amod bovine,serum
R2473 T2834 T2832 pobj serum,with
R2474 T2835 T2831 amod albumin,kit
R2475 T2836 T2826 prep as,using
R2476 T2837 T2838 det the,standard
R2477 T2838 T2836 pobj standard,as
R2478 T2839 T2841 punct (,Biochemicals
R2479 T2840 T2841 compound Pierce,Biochemicals
R248 T346 T344 pobj brain,in
R2480 T2841 T2826 parataxis Biochemicals,using
R2481 T2842 T2841 punct ",",Biochemicals
R2482 T2843 T2841 npadvmod Rockford,Biochemicals
R2483 T2844 T2843 punct ",",Rockford
R2484 T2845 T2843 conj IL,Rockford
R2485 T2846 T2845 punct ",",IL
R2486 T2847 T2843 npadvmod USA,Rockford
R2487 T2848 T2843 punct ),Rockford
R2488 T2849 T2841 punct .,Biochemicals
R2489 T2850 T2852 nsubjpass EMSA,performed
R249 T347 T337 prep after,enhances
R2490 T2851 T2852 auxpass was,performed
R2491 T2852 T2852 ROOT performed,performed
R2492 T2853 T2852 advcl using,performed
R2493 T2854 T2855 compound gel,shift
R2494 T2855 T2857 compound shift,system
R2495 T2856 T2857 compound assay,system
R2496 T2857 T2853 dobj system,using
R2497 T2858 T2857 punct (,system
R2498 T2859 T2857 appos Promega,system
R2499 T2860 T2859 punct ",",Promega
R250 T348 T347 pobj TBI,after
R2500 T2861 T2859 conj Madison,Promega
R2501 T2862 T2861 punct ",",Madison
R2502 T2863 T2861 conj WI,Madison
R2503 T2864 T2863 punct ",",WI
R2504 T2865 T2863 conj USA,WI
R2505 T2866 T2857 punct ),system
R2506 T2867 T2852 punct .,performed
R2507 T2868 T2870 compound Consensus,probe
R2508 T2869 T2870 compound oligonucleotide,probe
R2509 T2870 T2879 nsubjpass probe,end-labeled
R251 T349 T337 punct ",",enhances
R2510 T2871 T2870 punct (,probe
R2511 T2872 T2875 nummod 5,AGTTGAGGGGACTTTCCCAGGG-3
R2512 T2873 T2875 punct ′,AGTTGAGGGGACTTTCCCAGGG-3
R2513 T2874 T2875 punct -,AGTTGAGGGGACTTTCCCAGGG-3
R2514 T2875 T2870 appos AGTTGAGGGGACTTTCCCAGGG-3,probe
R2515 T2876 T2875 appos ′,AGTTGAGGGGACTTTCCCAGGG-3
R2516 T2877 T2875 punct ),AGTTGAGGGGACTTTCCCAGGG-3
R2517 T2878 T2879 auxpass was,end-labeled
R2518 T2879 T2879 ROOT end-labeled,end-labeled
R2519 T2880 T2879 agent by,end-labeled
R252 T350 T337 cc but,enhances
R2520 T2881 T2882 compound T4-polynucleotide,kinase
R2521 T2882 T2880 pobj kinase,by
R2522 T2883 T2879 advcl using,end-labeled
R2523 T2884 T2888 compound [,ATP
R2524 T2885 T2886 compound γ-32P,]
R2525 T2886 T2888 compound ],ATP
R2526 T2887 T2888 punct -,ATP
R2527 T2888 T2883 dobj ATP,using
R2528 T2889 T2891 punct (,Biotech.
R2529 T2890 T2891 compound Free,Biotech.
R253 T351 T353 advmod little,known
R2530 T2891 T2888 appos Biotech.,ATP
R2531 T2892 T2891 punct ",",Biotech.
R2532 T2893 T2891 npadvmod Beijing,Biotech.
R2533 T2894 T2893 punct ",",Beijing
R2534 T2895 T2891 npadvmod China,Biotech.
R2535 T2896 T2891 punct ),Biotech.
R2536 T2897 T2879 punct .,end-labeled
R2537 T2898 T2899 compound Nuclear,protein
R2538 T2899 T2904 nsubj protein,was
R2539 T2900 T2899 punct (,protein
R254 T352 T353 auxpass is,known
R2540 T2901 T2902 nummod 20,μg
R2541 T2902 T2899 appos μg,protein
R2542 T2903 T2899 punct ),protein
R2543 T2904 T2905 auxpass was,preincubated
R2544 T2905 T2905 ROOT preincubated,preincubated
R2545 T2906 T2905 prep in,preincubated
R2546 T2907 T2908 nummod 20,μL
R2547 T2908 T2910 nmod μL,buffer
R2548 T2909 T2910 amod binding,buffer
R2549 T2910 T2906 pobj buffer,in
R255 T353 T333 conj known,proved
R2550 T2911 T2910 acl containing,buffer
R2551 T2912 T2914 nummod 10,Tris-HCl
R2552 T2913 T2914 compound mM,Tris-HCl
R2553 T2914 T2911 dobj Tris-HCl,containing
R2554 T2915 T2916 punct (,PH
R2555 T2916 T2914 appos PH,Tris-HCl
R2556 T2917 T2916 nummod 7.5,PH
R2557 T2918 T2916 punct ),PH
R2558 T2919 T2914 punct ",",Tris-HCl
R2559 T2920 T2922 nummod 1,MgCl2
R256 T354 T353 prep about,known
R2560 T2921 T2922 compound mM,MgCl2
R2561 T2922 T2914 conj MgCl2,Tris-HCl
R2562 T2923 T2922 punct ",",MgCl2
R2563 T2924 T2922 npadvmod 0.5,MgCl2
R2564 T2925 T2926 compound mM,NaCl
R2565 T2926 T2926 ROOT NaCl,NaCl
R2566 T2927 T2926 punct ",",NaCl
R2567 T2928 T2929 nummod 4,%
R2568 T2929 T2930 compound %,glycerol
R2569 T2930 T2926 appos glycerol,NaCl
R257 T355 T356 det the,relationship
R2570 T2931 T2930 punct ",",glycerol
R2571 T2932 T2934 nummod 0.5,EDTA
R2572 T2933 T2934 compound mM,EDTA
R2573 T2934 T2926 conj EDTA,NaCl
R2574 T2935 T2934 punct ",",EDTA
R2575 T2936 T2938 nummod 0.5,DTT
R2576 T2937 T2938 compound mM,DTT
R2577 T2938 T2934 conj DTT,EDTA
R2578 T2939 T2938 punct ",",DTT
R2579 T2940 T2938 cc and,DTT
R258 T356 T354 pobj relationship,about
R2580 T2941 T2942 nummod 2,μg
R2581 T2942 T2944 compound μg,dI-dC
R2582 T2943 T2944 compound poly,dI-dC
R2583 T2944 T2934 appos dI-dC,EDTA
R2584 T2945 T2944 prep for,dI-dC
R2585 T2946 T2947 nummod 20,minutes
R2586 T2947 T2945 pobj minutes,for
R2587 T2948 T2947 prep on,minutes
R2588 T2949 T2948 pobj ice,on
R2589 T2950 T2926 punct .,NaCl
R259 T357 T356 prep between,relationship
R2590 T2951 T2964 prep After,continued
R2591 T2952 T2951 pobj addition,After
R2592 T2953 T2952 prep of,addition
R2593 T2954 T2959 det the,probe
R2594 T2955 T2956 nummod 1,μL
R2595 T2956 T2959 nmod μL,probe
R2596 T2957 T2959 amod 32P-labled,probe
R2597 T2958 T2959 compound oligonucleotide,probe
R2598 T2959 T2953 pobj probe,of
R2599 T2960 T2964 punct ",",continued
R260 T358 T357 pobj Nrf2,between
R2600 T2961 T2962 det the,incubation
R2601 T2962 T2964 nsubjpass incubation,continued
R2602 T2963 T2964 auxpass was,continued
R2603 T2964 T2964 ROOT continued,continued
R2604 T2965 T2964 prep for,continued
R2605 T2966 T2967 nummod 20,minutes
R2606 T2967 T2965 pobj minutes,for
R2607 T2968 T2967 prep on,minutes
R2608 T2969 T2968 pobj ice,on
R2609 T2970 T2964 punct .,continued
R261 T359 T358 cc and,Nrf2
R2610 T2971 T2973 det The,complexes
R2611 T2972 T2973 amod DNA-protein,complexes
R2612 T2973 T2975 nsubjpass complexes,separated
R2613 T2974 T2975 auxpass were,separated
R2614 T2975 T2975 ROOT separated,separated
R2615 T2976 T2975 agent by,separated
R2616 T2977 T2976 pobj electrophoresis,by
R2617 T2978 T2975 prep on,separated
R2618 T2979 T2980 nummod 4,%
R2619 T2980 T2983 nmod %,gel
R262 T360 T358 conj NF-κB,Nrf2
R2620 T2981 T2983 amod nondenaturing,gel
R2621 T2982 T2983 compound polyacrylamide,gel
R2622 T2983 T2978 pobj gel,on
R2623 T2984 T2975 prep in,separated
R2624 T2985 T2988 nummod 0.5,buffer
R2625 T2986 T2988 nummod ×,buffer
R2626 T2987 T2988 compound TBE,buffer
R2627 T2988 T2984 pobj buffer,in
R2628 T2989 T2988 punct (,buffer
R2629 T2990 T2988 appos tris-borate-EDTA,buffer
R263 T361 T356 prep in,relationship
R2630 T2991 T2988 punct ),buffer
R2631 T2992 T2975 prep at,separated
R2632 T2993 T2994 nummod 390,V
R2633 T2994 T2992 pobj V,at
R2634 T2995 T2975 prep for,separated
R2635 T2996 T2997 nummod 1,hour
R2636 T2997 T2995 pobj hour,for
R2637 T2998 T2975 prep at,separated
R2638 T2999 T3000 nummod 4,°
R2639 T3000 T2998 pobj °,at
R264 T362 T361 pobj astrocytes,in
R2640 T3001 T2975 npadvmod C,separated
R2641 T3002 T2975 punct .,separated
R2642 T3003 T3009 prep After,dried
R2643 T3004 T3003 pobj electrophoresis,After
R2644 T3005 T3009 punct ",",dried
R2645 T3006 T3007 det the,gel
R2646 T3007 T3009 nsubjpass gel,dried
R2647 T3008 T3009 auxpass was,dried
R2648 T3009 T3009 ROOT dried,dried
R2649 T3010 T3009 cc and,dried
R265 T363 T356 prep after,relationship
R2650 T3011 T3009 conj exposed,dried
R2651 T3012 T3011 prep to,exposed
R2652 T3013 T3014 compound X-ray,film
R2653 T3014 T3012 pobj film,to
R2654 T3015 T3017 punct (,Hyperfilm
R2655 T3016 T3017 compound Fuji,Hyperfilm
R2656 T3017 T3014 appos Hyperfilm,film
R2657 T3018 T3017 punct ",",Hyperfilm
R2658 T3019 T3017 npadvmod Tokyo,Hyperfilm
R2659 T3020 T3019 punct ",",Tokyo
R266 T364 T363 pobj TBI,after
R2660 T3021 T3019 conj Japan,Tokyo
R2661 T3022 T3017 punct ),Hyperfilm
R2662 T3023 T3009 punct .,dried
R2663 T3024 T3031 nsubjpass Levels,quantified
R2664 T3025 T3024 prep of,Levels
R2665 T3026 T3027 compound NF-κB,DNA
R2666 T3027 T3025 pobj DNA,of
R2667 T3028 T3029 amod binding,activity
R2668 T3029 T3025 pobj activity,of
R2669 T3030 T3031 auxpass were,quantified
R267 T365 T333 punct .,proved
R2670 T3031 T3031 ROOT quantified,quantified
R2671 T3032 T3031 agent by,quantified
R2672 T3033 T3034 compound software,ImageJ
R2673 T3034 T3032 pobj ImageJ,by
R2674 T3035 T3031 punct .,quantified
R268 T366 T369 advmod Hence,used
R269 T367 T369 punct ",",used
R270 T368 T369 nsubj we,used
R271 T369 T369 ROOT used,used
R272 T370 T372 amod primary,astrocytes
R273 T371 T372 amod cultured,astrocytes
R274 T372 T369 dobj astrocytes,used
R275 T373 T372 prep from,astrocytes
R276 T374 T376 preconj either,wildtype
R277 T375 T376 amod Nrf2,wildtype
R278 T376 T373 pobj wildtype,from
R2782 T3233 T3233 ROOT 2.5,2.5
R2783 T3234 T3233 punct .,2.5
R2784 T3235 T3237 compound RT-PCR,RNA
R2785 T3236 T3237 compound Total,RNA
R2786 T3237 T3238 nsubj RNA,was
R2787 T3238 T3238 ROOT was,was
R2788 T3239 T3238 acomp isolated,was
R2789 T3240 T3239 prep with,isolated
R279 T377 T376 cc or,wildtype
R2790 T3241 T3240 pobj Trizol,with
R2791 T3242 T3254 punct (,synthesized
R2792 T3243 T3252 nmod Invitrogen,cDNA
R2793 T3244 T3243 punct ",",Invitrogen
R2794 T3245 T3243 conj CA,Invitrogen
R2795 T3246 T3245 punct ",",CA
R2796 T3247 T3245 conj USA,CA
R2797 T3248 T3245 punct ),CA
R2798 T3249 T3245 punct ",",CA
R2799 T3250 T3245 cc and,CA
R280 T378 T379 compound knockout,mice
R2800 T3251 T3252 compound single-stranded,cDNA
R2801 T3252 T3254 nsubjpass cDNA,synthesized
R2802 T3253 T3254 auxpass was,synthesized
R2803 T3254 T3238 parataxis synthesized,was
R2804 T3255 T3254 prep from,synthesized
R2805 T3256 T3257 nummod 2,μg
R2806 T3257 T3255 pobj μg,from
R2807 T3258 T3257 prep of,μg
R2808 T3259 T3260 amod total,RNA
R2809 T3260 T3258 pobj RNA,of
R281 T379 T376 conj mice,wildtype
R2810 T3261 T3257 prep with,μg
R2811 T3262 T3263 amod BU-Script,RT-Kit
R2812 T3263 T3261 pobj RT-Kit,with
R2813 T3264 T3265 punct (,Biunique
R2814 T3265 T3263 appos Biunique,RT-Kit
R2815 T3266 T3265 punct ",",Biunique
R2816 T3267 T3265 conj Jiangsu,Biunique
R2817 T3268 T3267 punct ",",Jiangsu
R2818 T3269 T3267 conj China,Jiangsu
R2819 T3270 T3254 punct ),synthesized
R282 T380 T381 aux to,study
R2820 T3271 T3238 prep according,was
R2821 T3272 T3271 prep to,according
R2822 T3273 T3274 det the,manufacturer
R2823 T3274 T3276 poss manufacturer,protocol
R2824 T3275 T3274 case 's,manufacturer
R2825 T3276 T3272 pobj protocol,to
R2826 T3277 T3238 punct .,was
R2827 T3278 T3279 det The,cDNA
R2828 T3279 T3281 nsubjpass cDNA,stored
R2829 T3280 T3281 auxpass was,stored
R283 T381 T369 xcomp study,used
R2830 T3281 T3281 ROOT stored,stored
R2831 T3282 T3281 prep in,stored
R2832 T3283 T3286 nummod −,C.
R2833 T3284 T3285 nummod 20,°
R2834 T3285 T3286 compound °,C.
R2835 T3286 T3282 pobj C.,in
R2836 T3287 T3288 amod Reverse,transcription
R2837 T3288 T3290 nsubjpass transcription,conducted
R2838 T3289 T3290 auxpass was,conducted
R2839 T3290 T3281 conj conducted,stored
R284 T382 T383 det the,influence
R2840 T3291 T3290 prep with,conducted
R2841 T3292 T3295 compound GoTaq,Mix
R2842 T3293 T3295 compound Green,Mix
R2843 T3294 T3295 compound Master,Mix
R2844 T3295 T3291 pobj Mix,with
R2845 T3296 T3295 punct (,Mix
R2846 T3297 T3295 appos Promega,Mix
R2847 T3298 T3297 punct ",",Promega
R2848 T3299 T3297 conj WI,Promega
R2849 T3300 T3299 punct ",",WI
R285 T383 T381 dobj influence,study
R2850 T3301 T3299 appos USA,WI
R2851 T3302 T3295 punct ),Mix
R2852 T3303 T3290 prep according,conducted
R2853 T3304 T3303 prep to,according
R2854 T3305 T3306 det the,manufacturer
R2855 T3306 T3308 poss manufacturer,protocol
R2856 T3307 T3306 case 's,manufacturer
R2857 T3308 T3304 pobj protocol,to
R2858 T3309 T3290 punct .,conducted
R2859 T3310 T3312 nsubj Table,shows
R286 T384 T383 prep of,influence
R2860 T3311 T3310 nummod 1,Table
R2861 T3312 T3312 ROOT shows,shows
R2862 T3313 T3314 det the,primers
R2863 T3314 T3312 dobj primers,shows
R2864 T3315 T3314 cc and,primers
R2865 T3316 T3317 compound PCR,parameters
R2866 T3317 T3314 conj parameters,primers
R2867 T3318 T3312 punct .,shows
R2868 T3319 T3320 compound PCR,products
R2869 T3320 T3322 nsubjpass products,detected
R287 T385 T384 pobj Nrf2,of
R2870 T3321 T3322 auxpass were,detected
R2871 T3322 T3322 ROOT detected,detected
R2872 T3323 T3322 agent by,detected
R2873 T3324 T3326 amod agarose,electrophoresis
R2874 T3325 T3326 compound gel,electrophoresis
R2875 T3326 T3323 pobj electrophoresis,by
R2876 T3327 T3322 punct .,detected
R2877 T3328 T3329 det The,intensity
R2878 T3329 T3334 nsubjpass intensity,analyzed
R2879 T3330 T3329 prep of,intensity
R288 T386 T383 prep on,influence
R2880 T3331 T3332 det the,bands
R2881 T3332 T3330 pobj bands,of
R2882 T3333 T3334 auxpass was,analyzed
R2883 T3334 T3334 ROOT analyzed,analyzed
R2884 T3335 T3334 agent by,analyzed
R2885 T3336 T3337 compound ImageJ,program
R2886 T3337 T3335 pobj program,by
R2887 T3338 T3334 punct .,analyzed
R2888 T3339 T3340 det The,level
R2889 T3340 T3344 nsubjpass level,used
R289 T387 T388 det the,activation
R2890 T3341 T3340 prep of,level
R2891 T3342 T3341 pobj β-actin,of
R2892 T3343 T3344 auxpass was,used
R2893 T3344 T3344 ROOT used,used
R2894 T3345 T3344 prep as,used
R2895 T3346 T3348 det an,standard
R2896 T3347 T3348 amod internal,standard
R2897 T3348 T3345 pobj standard,as
R2898 T3349 T3344 punct .,used
R290 T388 T386 pobj activation,on
R291 T389 T388 prep of,activation
R292 T390 T389 pobj NF-κB,of
R293 T391 T388 cc and,activation
R294 T392 T388 conj expression,activation
R295 T393 T388 prep of,activation
R296 T394 T395 amod proinflammatory,cytokines
R297 T395 T393 pobj cytokines,of
R298 T396 T388 prep in,activation
R299 T397 T398 det a,model
R300 T398 T396 pobj model,in
R301 T399 T398 prep of,model
R302 T400 T399 pobj TBI,of
R303 T401 T388 prep in,activation
R304 T402 T401 pobj vitro,in
R305 T403 T369 punct .,used
R306 T404 T406 amod Primary,astrocytes
R307 T405 T406 amod cultured,astrocytes
R308 T406 T408 nsubjpass astrocytes,scratched
R309 T407 T408 auxpass were,scratched
R310 T408 T408 ROOT scratched,scratched
R311 T409 T410 aux to,mimic
R312 T410 T408 advcl mimic,scratched
R313 T411 T413 det the,injury
R314 T412 T413 amod traumatic,injury
R315 T413 T410 dobj injury,mimic
R316 T414 T413 prep in,injury
R317 T415 T414 pobj vitro,in
R318 T416 T408 punct .,scratched
R319 T417 T424 advmod Then,evaluated
R3191 T3697 T3697 ROOT 2.6,2.6
R3192 T3698 T3697 punct .,2.6
R3193 T3699 T3700 compound Western,Blot
R3194 T3700 T3702 nsubj Blot,obtain
R3195 T3701 T3702 aux To,obtain
R3196 T3702 T3702 ROOT obtain,obtain
R3197 T3703 T3704 amod total,protein
R3198 T3704 T3702 dobj protein,obtain
R3199 T3705 T3709 advmod lysates,homogenized
R320 T418 T420 det the,activity
R3200 T3706 T3709 punct ",",homogenized
R3201 T3707 T3709 nsubjpass cells,homogenized
R3202 T3708 T3709 auxpass were,homogenized
R3203 T3709 T3702 advcl homogenized,obtain
R3204 T3710 T3709 prep in,homogenized
R3205 T3711 T3712 compound RIPA,buffer
R3206 T3712 T3710 pobj buffer,in
R3207 T3713 T3715 punct (,%
R3208 T3714 T3715 nummod 1,%
R3209 T3715 T3775 nsubjpass %,estimated
R321 T419 T420 amod DNA-binding,activity
R3210 T3716 T3721 nummod NP40,deoxycholate
R3211 T3717 T3716 punct ",",NP40
R3212 T3718 T3719 nummod 0.5,%
R3213 T3719 T3721 nmod %,deoxycholate
R3214 T3720 T3721 compound sodium,deoxycholate
R3215 T3721 T3715 appos deoxycholate,%
R3216 T3722 T3721 punct ",",deoxycholate
R3217 T3723 T3724 nummod 0.1,%
R3218 T3724 T3715 appos %,%
R3219 T3725 T3715 npadvmod SDS,%
R322 T420 T424 nsubjpass activity,evaluated
R3220 T3726 T3725 punct ",",SDS
R3221 T3727 T3729 nummod 1,EDTA
R3222 T3728 T3729 compound mM,EDTA
R3223 T3729 T3725 appos EDTA,SDS
R3224 T3730 T3725 punct ",",SDS
R3225 T3731 T3733 nummod 1,EGTA
R3226 T3732 T3733 compound mM,EGTA
R3227 T3733 T3725 appos EGTA,SDS
R3228 T3734 T3725 punct ",",SDS
R3229 T3735 T3737 nummod 1,Na3VO4
R323 T421 T420 prep of,activity
R3230 T3736 T3737 compound mM,Na3VO4
R3231 T3737 T3725 appos Na3VO4,SDS
R3232 T3738 T3725 punct ",",SDS
R3233 T3739 T3741 nummod 20,NaF
R3234 T3740 T3741 compound mM,NaF
R3235 T3741 T3725 appos NaF,SDS
R3236 T3742 T3725 punct ",",SDS
R3237 T3743 T3745 nummod 0.5,DTT
R3238 T3744 T3745 compound mM,DTT
R3239 T3745 T3725 appos DTT,SDS
R324 T422 T421 pobj NF-κB,of
R3240 T3746 T3725 punct ",",SDS
R3241 T3747 T3749 nummod 1,PMSF
R3242 T3748 T3749 compound mM,PMSF
R3243 T3749 T3725 appos PMSF,SDS
R3244 T3750 T3725 punct ",",SDS
R3245 T3751 T3715 cc and,%
R3246 T3752 T3753 compound protease,inhibitor
R3247 T3753 T3754 compound inhibitor,cocktail
R3248 T3754 T3715 conj cocktail,%
R3249 T3755 T3715 prep in,%
R325 T423 T424 auxpass was,evaluated
R3250 T3756 T3755 pobj PBS,in
R3251 T3757 T3758 quantmod pH,7.4
R3252 T3758 T3715 dep 7.4,%
R3253 T3759 T3758 punct ),7.4
R3254 T3760 T3715 cc and,%
R3255 T3761 T3715 conj centrifuged,%
R3256 T3762 T3761 prep at,centrifuged
R3257 T3763 T3764 nummod "12,000",g
R3258 T3764 T3762 pobj g,at
R3259 T3765 T3761 prep for,centrifuged
R326 T424 T424 ROOT evaluated,evaluated
R3260 T3766 T3767 nummod 15,min
R3261 T3767 T3765 pobj min,for
R3262 T3768 T3767 prep at,min
R3263 T3769 T3770 nummod 4,°
R3264 T3770 T3773 nummod °,concentrations
R3265 T3771 T3773 nmod C.,concentrations
R3266 T3772 T3773 compound Protein,concentrations
R3267 T3773 T3768 pobj concentrations,at
R3268 T3774 T3775 auxpass were,estimated
R3269 T3775 T3702 conj estimated,obtain
R327 T425 T424 agent by,evaluated
R3270 T3776 T3775 agent by,estimated
R3271 T3777 T3781 compound Coomassie,Reagent
R3272 T3778 T3779 compound Plus,Protein
R3273 T3779 T3781 compound Protein,Reagent
R3274 T3780 T3781 compound Assay,Reagent
R3275 T3781 T3776 pobj Reagent,by
R3276 T3782 T3783 punct (,Pierce
R3277 T3783 T3781 appos Pierce,Reagent
R3278 T3784 T3783 punct ",",Pierce
R3279 T3785 T3783 prep IL,Pierce
R328 T426 T425 pobj EMSA,by
R3280 T3786 T3785 punct ",",IL
R3281 T3787 T3785 npadvmod USA,IL
R3282 T3788 T3783 punct ),Pierce
R3283 T3789 T3775 punct .,estimated
R3284 T3790 T3791 nummod Fifty,micrograms
R3285 T3791 T3798 nsubj micrograms,were
R3286 T3792 T3791 prep of,micrograms
R3287 T3793 T3797 det the,extracts
R3288 T3794 T3797 amod resulting,extracts
R3289 T3795 T3797 amod cytosolic,extracts
R329 T427 T424 punct .,evaluated
R3290 T3796 T3797 compound protein,extracts
R3291 T3797 T3792 pobj extracts,of
R3292 T3798 T3798 ROOT were,were
R3293 T3799 T3798 acomp heat-denatured,were
R3294 T3800 T3799 prep in,heat-denatured
R3295 T3801 T3804 compound Laemmli,buffer
R3296 T3802 T3804 compound sample,buffer
R3297 T3803 T3804 compound loading,buffer
R3298 T3804 T3800 pobj buffer,in
R3299 T3805 T3799 punct ",",heat-denatured
R330 T428 T429 det The,mRNA
R3300 T3806 T3798 advcl separated,were
R3301 T3807 T3806 agent by,separated
R3302 T3808 T3809 nummod 10,%
R3303 T3809 T3815 compound %,electrophoresis
R3304 T3810 T3812 compound sodium,sulfate
R3305 T3811 T3812 compound dodecyl,sulfate
R3306 T3812 T3814 compound sulfate,gel
R3307 T3813 T3814 compound polyacrylamide,gel
R3308 T3814 T3815 compound gel,electrophoresis
R3309 T3815 T3807 pobj electrophoresis,by
R331 T429 T444 nsubjpass mRNA,evaluated
R3310 T3816 T3806 punct ",",separated
R3311 T3817 T3806 cc and,separated
R3312 T3818 T3806 conj electroblotted,separated
R3313 T3819 T3818 prep onto,electroblotted
R3314 T3820 T3822 det a,membrane
R3315 T3821 T3822 amod nitrocellulose,membrane
R3316 T3822 T3819 pobj membrane,onto
R3317 T3823 T3798 punct .,were
R3318 T3824 T3829 prep For,blocked
R3319 T3825 T3824 pobj immunoblotting,For
R332 T430 T429 cc and,mRNA
R3320 T3826 T3829 punct ",",blocked
R3321 T3827 T3829 nsubjpass membranes,blocked
R3322 T3828 T3829 auxpass were,blocked
R3323 T3829 T3829 ROOT blocked,blocked
R3324 T3830 T3829 prep with,blocked
R3325 T3831 T3832 nummod 5,%
R3326 T3832 T3835 nmod %,milk
R3327 T3833 T3835 amod nonfat,milk
R3328 T3834 T3835 amod dry,milk
R3329 T3835 T3830 pobj milk,with
R333 T431 T432 compound protein,levels
R3330 T3836 T3835 prep in,milk
R3331 T3837 T3838 compound saline,buffer
R3332 T3838 T3839 compound buffer,overnight
R3333 T3839 T3836 pobj overnight,in
R3334 T3840 T3829 prep at,blocked
R3335 T3841 T3842 nummod 4,°
R3336 T3842 T3843 nummod °,C
R3337 T3843 T3840 pobj C,at
R3338 T3844 T3829 punct ",",blocked
R3339 T3845 T3829 cc and,blocked
R334 T432 T429 conj levels,mRNA
R3340 T3846 T3848 det the,antibodies
R3341 T3847 T3848 amod following,antibodies
R3342 T3848 T3850 nsubjpass antibodies,used
R3343 T3849 T3850 auxpass were,used
R3344 T3850 T3829 conj used,blocked
R3345 T3851 T3852 punct :,anti-β-actin
R3346 T3852 T3850 prep anti-β-actin,used
R3347 T3853 T3854 punct (,sc-130657
R3348 T3854 T3852 dep sc-130657,anti-β-actin
R3349 T3855 T3854 punct ",",sc-130657
R335 T433 T432 prep of,levels
R3350 T3856 T3858 compound Santa,Biotechnology
R3351 T3857 T3858 compound Cruz,Biotechnology
R3352 T3858 T3854 conj Biotechnology,sc-130657
R3353 T3859 T3858 punct ",",Biotechnology
R3354 T3860 T3858 conj CA,Biotechnology
R3355 T3861 T3860 punct ",",CA
R3356 T3862 T3860 conj USA,CA
R3357 T3863 T3860 punct ",",CA
R3358 T3864 T3865 nummod 43,kDa
R3359 T3865 T3860 appos kDa,CA
R336 T434 T433 pobj TNF-α,of
R3360 T3866 T3865 punct ),kDa
R3361 T3867 T3865 cc and,kDa
R3362 T3868 T3869 amod anti-matrix,metallopeptidase
R3363 T3869 T3865 conj metallopeptidase,kDa
R3364 T3870 T3869 nummod 9,metallopeptidase
R3365 T3871 T3872 punct (,MMP9
R3366 T3872 T3869 appos MMP9,metallopeptidase
R3367 T3873 T3872 punct ),MMP9
R3368 T3874 T3875 punct (,sc-6841
R3369 T3875 T3869 appos sc-6841,metallopeptidase
R337 T435 T434 punct ",",TNF-α
R3370 T3876 T3875 punct ",",sc-6841
R3371 T3877 T3879 compound Santa,Biotechnology
R3372 T3878 T3879 compound Cruz,Biotechnology
R3373 T3879 T3875 appos Biotechnology,sc-6841
R3374 T3880 T3879 punct ",",Biotechnology
R3375 T3881 T3879 conj CA,Biotechnology
R3376 T3882 T3881 punct ",",CA
R3377 T3883 T3881 conj USA,CA
R3378 T3884 T3881 punct ",",CA
R3379 T3885 T3886 nummod 92,kDa
R338 T436 T434 conj IL-1β,TNF-α
R3380 T3886 T3881 appos kDa,CA
R3381 T3887 T3875 punct ),sc-6841
R3382 T3888 T3854 punct .,sc-130657
R3383 T3889 T3891 det Each,antibody
R3384 T3890 T3891 amod primary,antibody
R3385 T3891 T3893 nsubjpass antibody,diluted
R3386 T3892 T3893 auxpass was,diluted
R3387 T3893 T3893 ROOT diluted,diluted
R3388 T3894 T3893 advmod appropriately,diluted
R3389 T3895 T3893 prep in,diluted
R339 T437 T436 punct ",",IL-1β
R3390 T3896 T3895 pcomp blocking,in
R3391 T3897 T3896 dobj buffer,blocking
R3392 T3898 T3893 cc and,diluted
R3393 T3899 T3900 advmod then,added
R3394 T3900 T3893 conj added,diluted
R3395 T3901 T3900 prep to,added
R3396 T3902 T3903 det the,blots
R3397 T3903 T3901 pobj blots,to
R3398 T3904 T3900 prep for,added
R3399 T3905 T3906 nummod 1,h
R340 T438 T436 conj IL-6,IL-1β
R3400 T3906 T3904 pobj h,for
R3401 T3907 T3906 prep at,h
R3402 T3908 T3909 compound room,temperature
R3403 T3909 T3907 pobj temperature,at
R3404 T3910 T3900 punct .,added
R3405 T3911 T3912 det The,blots
R3406 T3912 T3914 nsubjpass blots,washed
R3407 T3913 T3914 auxpass were,washed
R3408 T3914 T3914 ROOT washed,washed
R3409 T3915 T3916 nummod three,times
R341 T439 T438 punct ",",IL-6
R3410 T3916 T3914 npadvmod times,washed
R3411 T3917 T3914 prep in,washed
R3412 T3918 T3920 det the,buffer
R3413 T3919 T3920 amod washing,buffer
R3414 T3920 T3917 pobj buffer,in
R3415 T3921 T3914 cc and,washed
R3416 T3922 T3914 conj covered,washed
R3417 T3923 T3922 prep with,covered
R3418 T3924 T3928 det the,antibody
R3419 T3925 T3928 amod horseradish,antibody
R342 T440 T438 cc and,IL-6
R3420 T3926 T3928 amod peroxidase-linked,antibody
R3421 T3927 T3928 amod secondary,antibody
R3422 T3928 T3923 pobj antibody,with
R3423 T3929 T3922 prep at,covered
R3424 T3930 T3931 det a,1
R3425 T3931 T3929 pobj 1,at
R3426 T3932 T3934 punct :,dilution
R3427 T3933 T3934 nummod 2000,dilution
R3428 T3934 T3940 nsubjpass dilution,incubated
R3429 T3935 T3934 prep for,dilution
R343 T441 T438 conj MMP9,IL-6
R3430 T3936 T3938 nummod 1,Blots
R3431 T3937 T3938 compound h.,Blots
R3432 T3938 T3935 pobj Blots,for
R3433 T3939 T3940 auxpass were,incubated
R3434 T3940 T3914 conj incubated,washed
R3435 T3941 T3940 prep with,incubated
R3436 T3942 T3943 amod enhanced,chemiluminescence
R3437 T3943 T3941 pobj chemiluminescence,with
R3438 T3944 T3945 punct (,ECL
R3439 T3945 T3943 appos ECL,chemiluminescence
R344 T442 T444 auxpass were,evaluated
R3440 T3946 T3945 punct ),ECL
R3441 T3947 T3948 compound detection,system
R3442 T3948 T3943 conj system,chemiluminescence
R3443 T3949 T3948 punct (,system
R3444 T3950 T3951 compound Amersham,Biosciences
R3445 T3951 T3948 appos Biosciences,system
R3446 T3952 T3951 punct ",",Biosciences
R3447 T3953 T3951 conj Bucks,Biosciences
R3448 T3954 T3953 punct ",",Bucks
R3449 T3955 T3953 conj UK,Bucks
R345 T443 T444 advmod also,evaluated
R3450 T3956 T3953 punct ),Bucks
R3451 T3957 T3940 cc and,incubated
R3452 T3958 T3940 conj exposed,incubated
R3453 T3959 T3958 prep to,exposed
R3454 T3960 T3961 amod radiographic,film
R3455 T3961 T3959 pobj film,to
R3456 T3962 T3964 punct (,Hyperfilm
R3457 T3963 T3964 compound Fuji,Hyperfilm
R3458 T3964 T3961 appos Hyperfilm,film
R3459 T3965 T3964 punct ",",Hyperfilm
R346 T444 T444 ROOT evaluated,evaluated
R3460 T3966 T3964 conj Tokyo,Hyperfilm
R3461 T3967 T3966 punct ",",Tokyo
R3462 T3968 T3966 conj Japan,Tokyo
R3463 T3969 T3964 punct ),Hyperfilm
R3464 T3970 T3940 punct .,incubated
R3465 T3971 T3973 nsubjpass ImageJ,used
R3466 T3972 T3973 auxpass was,used
R3467 T3973 T3973 ROOT used,used
R3468 T3974 T3975 aux to,analyze
R3469 T3975 T3973 xcomp analyze,used
R347 T445 T444 punct .,evaluated
R3470 T3976 T3977 det the,intensity
R3471 T3977 T3975 dobj intensity,analyze
R3472 T3978 T3977 prep of,intensity
R3473 T3979 T3980 det the,blots
R3474 T3980 T3978 pobj blots,of
R3475 T3981 T3973 punct .,used
R3476 T3982 T3983 det The,level
R3477 T3983 T3987 nsubjpass level,used
R3478 T3984 T3983 prep of,level
R3479 T3985 T3984 pobj β-actin,of
R348 T446 T447 compound Gelatin,zymography
R3480 T3986 T3987 auxpass was,used
R3481 T3987 T3987 ROOT used,used
R3482 T3988 T3987 prep as,used
R3483 T3989 T3990 amod internal,standard
R3484 T3990 T3988 pobj standard,as
R3485 T3991 T3987 punct .,used
R349 T447 T449 nsubjpass zymography,performed
R350 T448 T449 auxpass was,performed
R351 T449 T449 ROOT performed,performed
R352 T450 T451 aux to,detect
R353 T451 T449 advcl detect,performed
R354 T452 T453 det the,activity
R355 T453 T451 dobj activity,detect
R356 T454 T453 prep of,activity
R357 T455 T454 pobj MMP9,of
R358 T456 T449 punct .,performed
R359 T457 T458 det The,activity
R360 T458 T469 nsubjpass activity,upregulated
R361 T459 T458 prep of,activity
R362 T460 T459 pobj NF-κB,of
R363 T461 T458 cc and,activity
R364 T462 T458 conj expression,activity
R365 T463 T462 prep of,expression
R366 T464 T465 amod proinflammatory,cytokines
R367 T465 T463 pobj cytokines,of
R368 T466 T465 acl mentioned,cytokines
R369 T467 T466 advmod above,mentioned
R370 T468 T469 auxpass were,upregulated
R371 T469 T469 ROOT upregulated,upregulated
R372 T470 T469 prep at,upregulated
R373 T471 T472 nummod 24,h
R374 T472 T470 pobj h,at
R375 T473 T469 prep after,upregulated
R376 T474 T473 pobj scratch,after
R377 T475 T469 punct .,upregulated
R378 T476 T477 det The,expression
R379 T477 T484 nsubjpass expression,elevated
R380 T478 T477 cc and,expression
R381 T479 T477 conj activity,expression
R382 T480 T477 prep of,expression
R383 T481 T480 pobj MMP9,of
R384 T482 T484 auxpass were,elevated
R385 T483 T484 advmod also,elevated
R386 T484 T484 ROOT elevated,elevated
R387 T485 T484 punct .,elevated
R3873 T4560 T4560 ROOT 2.8,2.8
R3874 T4561 T4560 punct .,2.8
R3875 T4562 T4564 compound Gelatine,Cells
R3876 T4563 T4564 compound Zymography,Cells
R3877 T4564 T4569 nsubjpass Cells,homogenized
R3878 T4565 T4564 prep of,Cells
R3879 T4566 T4567 nummod four,groups
R388 T486 T489 cc And,was
R3880 T4567 T4565 pobj groups,of
R3881 T4568 T4569 auxpass were,homogenized
R3882 T4569 T4569 ROOT homogenized,homogenized
R3883 T4570 T4569 prep in,homogenized
R3884 T4571 T4572 compound lysis,buffer
R3885 T4572 T4570 pobj buffer,in
R3886 T4573 T4572 acl containing,buffer
R3887 T4574 T4576 nummod 50,Tris-HCl
R3888 T4575 T4576 compound mM,Tris-HCl
R3889 T4576 T4573 dobj Tris-HCl,containing
R389 T487 T488 amod such,tendency
R3890 T4577 T4578 punct (,pH
R3891 T4578 T4576 appos pH,Tris-HCl
R3892 T4579 T4578 nummod 7.4,pH
R3893 T4580 T4578 punct ),pH
R3894 T4581 T4576 punct ",",Tris-HCl
R3895 T4582 T4584 nummod 150,NaCl
R3896 T4583 T4584 compound mM,NaCl
R3897 T4584 T4576 conj NaCl,Tris-HCl
R3898 T4585 T4584 punct ",",NaCl
R3899 T4586 T4588 nummod 5,CaCl2
R390 T488 T489 nsubj tendency,was
R3900 T4587 T4588 compound mM,CaCl2
R3901 T4588 T4584 conj CaCl2,NaCl
R3902 T4589 T4588 punct ",",CaCl2
R3903 T4590 T4592 nummod 0.2,NaN3
R3904 T4591 T4592 compound mM,NaN3
R3905 T4592 T4588 conj NaN3,CaCl2
R3906 T4593 T4592 punct ",",NaN3
R3907 T4594 T4592 cc and,NaN3
R3908 T4595 T4596 nummod 0.01,%
R3909 T4596 T4597 compound %,Triton
R391 T489 T489 ROOT was,was
R3910 T4597 T4592 conj Triton,NaN3
R3911 T4598 T4569 punct .,homogenized
R3912 T4599 T4600 amod Soluble,extracts
R3913 T4600 T4602 nsubjpass extracts,separated
R3914 T4601 T4602 auxpass were,separated
R3915 T4602 T4602 ROOT separated,separated
R3916 T4603 T4602 agent by,separated
R3917 T4604 T4603 pobj centrifugation,by
R3918 T4605 T4602 cc and,separated
R3919 T4606 T4614 nsubjpass stored,performed
R392 T490 T491 advmod much,more
R3920 T4607 T4606 prep at,stored
R3921 T4608 T4609 nummod 20,°
R3922 T4609 T4612 compound °,zymography
R3923 T4610 T4612 compound C.,zymography
R3924 T4611 T4612 compound Gelatin,zymography
R3925 T4612 T4607 pobj zymography,at
R3926 T4613 T4614 auxpass was,performed
R3927 T4614 T4602 conj performed,separated
R3928 T4615 T4614 xcomp according,performed
R3929 T4616 T4615 prep to,according
R393 T491 T492 advmod more,prominent
R3930 T4617 T4618 det the,manufacturer
R3931 T4618 T4620 poss manufacturer,instructions
R3932 T4619 T4618 case 's,manufacturer
R3933 T4620 T4616 pobj instructions,to
R3934 T4621 T4624 punct (,Inc
R3935 T4622 T4624 compound Genmed,Inc
R3936 T4623 T4624 compound Scientifics,Inc
R3937 T4624 T4620 appos Inc,instructions
R3938 T4625 T4624 punct ",",Inc
R3939 T4626 T4624 conj MA,Inc
R394 T492 T489 acomp prominent,was
R3940 T4627 T4626 punct ",",MA
R3941 T4628 T4626 appos USA,MA
R3942 T4629 T4626 punct ),MA
R3943 T4630 T4614 punct .,performed
R3944 T4631 T4639 advmod Briefly,separated
R3945 T4632 T4639 punct ",",separated
R3946 T4633 T4637 nummod 40,extracts
R3947 T4634 T4637 compound μg,extracts
R3948 T4635 T4636 compound cytosolic,protein
R3949 T4636 T4637 compound protein,extracts
R395 T493 T492 prep in,prominent
R3950 T4637 T4639 nsubjpass extracts,separated
R3951 T4638 T4639 auxpass were,separated
R3952 T4639 T4639 ROOT separated,separated
R3953 T4640 T4639 prep by,separated
R3954 T4641 T4640 pobj electrophoresis,by
R3955 T4642 T4639 punct .,separated
R3956 T4643 T4647 advmod Then,renatured
R3957 T4644 T4645 det the,proteins
R3958 T4645 T4647 nsubjpass proteins,renatured
R3959 T4646 T4647 auxpass were,renatured
R396 T494 T495 compound Nrf2,KO
R3960 T4647 T4647 ROOT renatured,renatured
R3961 T4648 T4647 agent by,renatured
R3962 T4649 T4648 pobj incubation,by
R3963 T4650 T4647 prep in,renatured
R3964 T4651 T4652 nummod 2.5,%
R3965 T4652 T4654 compound %,X-100
R3966 T4653 T4654 compound Triton,X-100
R3967 T4654 T4650 pobj X-100,in
R3968 T4655 T4647 cc and,renatured
R3969 T4656 T4657 advmod then,incubated
R397 T495 T496 compound KO,astrocytes
R3970 T4657 T4647 conj incubated,renatured
R3971 T4658 T4657 prep in,incubated
R3972 T4659 T4660 compound substrate,buffer
R3973 T4660 T4658 pobj buffer,in
R3974 T4661 T4660 prep for,buffer
R3975 T4662 T4663 nummod 40,h
R3976 T4663 T4661 pobj h,for
R3977 T4664 T4657 prep at,incubated
R3978 T4665 T4666 nummod 37,°
R3979 T4666 T4664 pobj °,at
R398 T496 T493 pobj astrocytes,in
R3980 T4667 T4657 conj C,incubated
R3981 T4668 T4669 aux to,enable
R3982 T4669 T4657 advcl enable,incubated
R3983 T4670 T4671 det the,MMP9
R3984 T4671 T4669 dobj MMP9,enable
R3985 T4672 T4673 aux to,cleave
R3986 T4673 T4669 xcomp cleave,enable
R3987 T4674 T4675 det the,gelatin
R3988 T4675 T4673 dobj gelatin,cleave
R3989 T4676 T4647 punct .,renatured
R399 T497 T492 prep than,prominent
R3990 T4677 T4685 prep After,stained
R3991 T4678 T4677 pcomp rinsing,After
R3992 T4679 T4678 prep in,rinsing
R3993 T4680 T4679 pobj water,in
R3994 T4681 T4685 punct ",",stained
R3995 T4682 T4683 det each,gel
R3996 T4683 T4685 nsubjpass gel,stained
R3997 T4684 T4685 auxpass was,stained
R3998 T4685 T4685 ROOT stained,stained
R3999 T4686 T4685 prep with,stained
R400 T498 T497 pobj that,than
R4000 T4687 T4688 compound Coomassie,blue
R4001 T4688 T4686 pobj blue,with
R4002 T4689 T4688 prep for,blue
R4003 T4690 T4691 nummod 1,h
R4004 T4691 T4689 pobj h,for
R4005 T4692 T4691 cc and,h
R4006 T4693 T4688 conj destained,blue
R4007 T4694 T4693 prep in,destained
R4008 T4695 T4696 nummod 50,%
R4009 T4696 T4697 compound %,methanol
R401 T499 T498 prep in,that
R4010 T4697 T4694 pobj methanol,in
R4011 T4698 T4685 punct .,stained
R4012 T4699 T4700 amod Proteolytic,activities
R4013 T4700 T4702 nsubjpass activities,showed
R4014 T4701 T4702 auxpass were,showed
R4015 T4702 T4702 ROOT showed,showed
R4016 T4703 T4702 agent by,showed
R4017 T4704 T4705 amod clear,bands
R4018 T4705 T4703 pobj bands,by
R4019 T4706 T4705 prep in,bands
R402 T500 T501 compound WT,astrocytes
R4020 T4707 T4708 amod blue,gel
R4021 T4708 T4706 pobj gel,in
R4022 T4709 T4710 nsubj which,indicates
R4023 T4710 T4702 advcl indicates,showed
R4024 T4711 T4712 det the,lysis
R4025 T4712 T4710 dobj lysis,indicates
R4026 T4713 T4712 prep of,lysis
R4027 T4714 T4715 det the,substrate
R4028 T4715 T4713 pobj substrate,of
R4029 T4716 T4702 punct .,showed
R403 T501 T499 pobj astrocytes,in
R4030 T4717 T4723 nsubjpass Quantification,performed
R4031 T4718 T4717 prep of,Quantification
R4032 T4719 T4721 compound MMP9,density
R4033 T4720 T4721 compound band,density
R4034 T4721 T4718 pobj density,of
R4035 T4722 T4723 auxpass was,performed
R4036 T4723 T4723 ROOT performed,performed
R4037 T4724 T4723 prep with,performed
R4038 T4725 T4726 compound image,analysis
R4039 T4726 T4727 compound analysis,program
R404 T502 T489 punct .,was
R4040 T4727 T4728 compound program,ImageJ
R4041 T4728 T4724 pobj ImageJ,with
R4042 T4729 T4723 punct .,performed
R405 T503 T504 det These,results
R406 T504 T505 nsubj results,suggest
R407 T505 T505 ROOT suggest,suggest
R408 T506 T512 mark that,induce
R4082 T4799 T4799 ROOT 2.9,2.9
R4083 T4800 T4799 punct .,2.9
R4084 T4801 T4802 compound Statistical,Analysis
R4085 T4802 T4803 compound Analysis,Data
R4086 T4803 T4805 nsubjpass Data,expressed
R4087 T4804 T4805 auxpass were,expressed
R4088 T4805 T4805 ROOT expressed,expressed
R4089 T4806 T4811 mark as,evaluated
R409 T507 T508 det the,absence
R4090 T4807 T4809 amod mean,SD
R4091 T4808 T4809 compound ±,SD
R4092 T4809 T4811 nsubj SD,evaluated
R4093 T4810 T4809 cc and,SD
R4094 T4811 T4805 advcl evaluated,expressed
R4095 T4812 T4811 agent by,evaluated
R4096 T4813 T4812 pobj ANOVA,by
R4097 T4814 T4813 cc and,ANOVA
R4098 T4815 T4813 conj LSD,ANOVA
R4099 T4816 T4818 amod multiple,test
R410 T508 T512 nsubj absence,induce
R4100 T4817 T4818 compound comparison,test
R4101 T4818 T4811 dobj test,evaluated
R4102 T4819 T4805 punct .,expressed
R4103 T4820 T4821 compound P,values
R4104 T4821 T4822 nsubj values,<
R4105 T4822 T4825 dep <,considered
R4106 T4823 T4825 nsubjpass 0.05,considered
R4107 T4824 T4825 auxpass were,considered
R4108 T4825 T4825 ROOT considered,considered
R4109 T4826 T4827 aux to,be
R411 T509 T508 prep of,absence
R4110 T4827 T4825 xcomp be,considered
R4111 T4828 T4827 acomp significant,be
R4112 T4829 T4825 punct .,considered
R4113 T4830 T4831 det All,analyses
R4114 T4831 T4833 nsubjpass analyses,performed
R4115 T4832 T4833 auxpass were,performed
R4116 T4833 T4833 ROOT performed,performed
R4117 T4834 T4833 prep by,performed
R4118 T4835 T4834 pcomp using,by
R4119 T4836 T4838 nmod SPSS,software
R412 T510 T509 pobj Nrf2,of
R4120 T4837 T4836 nummod 18.0,SPSS
R4121 T4838 T4835 dobj software,using
R4122 T4839 T4833 punct .,performed
R413 T511 T512 aux may,induce
R414 T512 T505 ccomp induce,suggest
R415 T513 T514 advmod more,aggressive
R416 T514 T515 amod aggressive,inflammation
R417 T515 T512 dobj inflammation,induce
R418 T516 T512 prep through,induce
R419 T517 T516 pobj activation,through
R420 T518 T517 prep of,activation
R421 T519 T518 pobj NF-κB,of
R422 T520 T517 cc and,activation
R4228 T4973 T4973 ROOT 3.1,3.1
R4229 T4974 T4973 punct .,3.1
R423 T521 T523 amod downstream,cytokines
R4230 T4975 T4990 nsubjpass Depletion,detected
R4231 T4976 T4975 prep of,Depletion
R4232 T4977 T4978 compound Nrf2,Aggravated
R4233 T4978 T4976 pobj Aggravated,of
R4234 T4979 T4981 det the,Death
R4235 T4980 T4981 compound Cell,Death
R4236 T4981 T4978 dobj Death,Aggravated
R4237 T4982 T4981 prep in,Death
R4238 T4983 T4982 pobj Astrocytes,in
R4239 T4984 T4990 mark after,detected
R424 T522 T523 compound proinflammatory,cytokines
R4240 T4985 T4988 compound Scratch,death
R4241 T4986 T4987 compound Injury,Cell
R4242 T4987 T4988 compound Cell,death
R4243 T4988 T4990 nsubjpass death,detected
R4244 T4989 T4990 auxpass was,detected
R4245 T4990 T4990 ROOT detected,detected
R4246 T4991 T4990 agent by,detected
R4247 T4992 T4991 pobj microscope,by
R4248 T4993 T4992 cc and,microscope
R4249 T4994 T4995 compound CCK-8,analysis
R425 T523 T517 conj cytokines,activation
R4250 T4995 T4992 conj analysis,microscope
R4251 T4996 T4995 prep at,analysis
R4252 T4997 T4998 nummod 24,h
R4253 T4998 T4996 pobj h,at
R4254 T4999 T4990 prep after,detected
R4255 T5000 T4999 pobj scratch,after
R4256 T5001 T4990 punct .,detected
R4257 T5002 T5003 det The,detachment
R4258 T5003 T5009 nsubj detachment,lost
R4259 T5004 T5003 prep from,detachment
R426 T524 T512 prep in,induce
R4260 T5005 T5006 compound culture,plate
R4261 T5006 T5004 pobj plate,from
R4262 T5007 T5009 punct ",",lost
R4263 T5008 T5009 nsubj cell,lost
R4264 T5009 T5009 ROOT lost,lost
R4265 T5010 T5009 punct ",",lost
R4266 T5011 T5009 cc and,lost
R4267 T5012 T5014 amod cytoplasmic,distortion
R4268 T5013 T5014 compound process,distortion
R4269 T5014 T5017 nsubjpass distortion,observed
R427 T525 T524 pobj astrocytes,in
R4270 T5015 T5017 auxpass were,observed
R4271 T5016 T5017 advmod mostly,observed
R4272 T5017 T5009 conj observed,lost
R4273 T5018 T5017 prep in,observed
R4274 T5019 T5020 det both,sides
R4275 T5020 T5018 pobj sides,in
R4276 T5021 T5020 prep of,sides
R4277 T5022 T5023 compound scratch,line
R4278 T5023 T5021 pobj line,of
R4279 T5024 T5023 prep in,line
R428 T526 T505 punct .,suggest
R4280 T5025 T5027 compound group,TBI
R4281 T5026 T5027 compound KO,TBI
R4282 T5027 T5024 pobj TBI,in
R4283 T5028 T5017 punct .,observed
R4284 T5029 T5030 nummod CCK-8,assay
R4285 T5030 T5032 nsubj assay,showed
R4286 T5031 T5032 advmod also,showed
R4287 T5032 T5032 ROOT showed,showed
R4288 T5033 T5035 amod lower,value
R4289 T5034 T5035 compound OD,value
R4290 T5035 T5032 dobj value,showed
R4291 T5036 T5035 prep of,value
R4292 T5037 T5039 compound group,TBI
R4293 T5038 T5039 compound KO,TBI
R4294 T5039 T5036 pobj TBI,of
R4295 T5040 T5041 punct (,0.38
R4296 T5041 T5043 nummod 0.38,0.064
R4297 T5042 T5043 nummod ±,0.064
R4298 T5043 T5039 appos 0.064,TBI
R4299 T5044 T5032 punct ),showed
R4300 T5045 T5032 prep than,showed
R4301 T5046 T5045 pobj that,than
R4302 T5047 T5046 prep of,that
R4303 T5048 T5047 pobj group,of
R4304 T5049 T5050 compound WT,TBI
R4305 T5050 T5048 appos TBI,group
R4306 T5051 T5052 punct (,0.98
R4307 T5052 T5054 nummod 0.98,0.098
R4308 T5053 T5054 nummod ±,0.098
R4309 T5054 T5048 appos 0.098,group
R4310 T5055 T5032 punct ),showed
R4311 T5056 T5032 punct (,showed
R4312 T5057 T5057 ROOT P,P
R4313 T5058 T5057 nummod <,P
R4314 T5059 T5057 nummod 0.01,P
R4315 T5060 T5057 punct ),P
R4316 T5061 T5057 punct ",",P
R4317 T5062 T5066 nsubj which,suggested
R4319 T5065 T5066 advmod also,suggested
R4320 T5066 T5057 relcl suggested,P
R4321 T5067 T5069 amod more,death
R4322 T5068 T5069 compound cell,death
R4323 T5069 T5066 dobj death,suggested
R4324 T5070 T5069 prep in,death
R4325 T5071 T5073 compound group,TBI
R4326 T5072 T5073 compound KO,TBI
R4327 T5073 T5070 pobj TBI,in
R4328 T5074 T5075 punct (,Figure
R4329 T5075 T5073 appos Figure,TBI
R4330 T5076 T5075 nummod 1,Figure
R4331 T5077 T5073 punct ),TBI
R4332 T5078 T5057 punct .,P
R4333 T5079 T5080 expl There,was
R4334 T5080 T5080 ROOT was,was
R4335 T5081 T5082 det no,difference
R4336 T5082 T5080 attr difference,was
R4337 T5083 T5082 prep between,difference
R4338 T5084 T5086 nummod two,groups
R4339 T5085 T5086 amod sham-operated,groups
R4340 T5086 T5083 pobj groups,between
R4341 T5087 T5080 punct .,was
R4445 T5227 T5227 ROOT 3.2,3.2
R4446 T5228 T5227 punct .,3.2
R4447 T5229 T5244 nsubj Disruption,reported
R4448 T5230 T5229 prep of,Disruption
R4449 T5231 T5233 compound Nrf2,Upregulation
R4450 T5232 T5233 compound Enhanced,Upregulation
R4451 T5233 T5230 pobj Upregulation,of
R4452 T5234 T5233 prep of,Upregulation
R4453 T5235 T5236 compound NF-κB,DNA-Binding
R4454 T5236 T5234 pobj DNA-Binding,of
R4455 T5237 T5229 conj Activity,Disruption
R4456 T5238 T5229 prep after,Disruption
R4457 T5239 T5240 compound Scratch,Injury
R4458 T5240 T5238 pobj Injury,after
R4459 T5241 T5244 nsubjpass It,reported
R4460 T5242 T5244 aux has,reported
R4461 T5243 T5244 auxpass been,reported
R4462 T5244 T5244 ROOT reported,reported
R4463 T5245 T5248 mark that,activated
R4464 T5246 T5248 nsubjpass NF-κB,activated
R4465 T5247 T5248 auxpass is,activated
R4466 T5248 T5244 ccomp activated,reported
R4467 T5249 T5248 prep in,activated
R4468 T5250 T5249 pobj brain,in
R4469 T5251 T5248 prep after,activated
R4470 T5252 T5255 nmod TBI,]
R4471 T5253 T5255 nmod [,]
R4472 T5254 T5255 nummod 2,]
R4473 T5255 T5251 pobj ],after
R4474 T5256 T5244 punct .,reported
R4475 T5257 T5260 advmod Here,studied
R4476 T5258 T5260 punct ",",studied
R4477 T5259 T5260 nsubj we,studied
R4478 T5260 T5260 ROOT studied,studied
R4479 T5261 T5263 det the,activity
R4480 T5262 T5263 amod DNA-binding,activity
R4481 T5263 T5260 dobj activity,studied
R4482 T5264 T5263 prep of,activity
R4483 T5265 T5264 pobj NF-κB,of
R4484 T5266 T5265 prep of,NF-κB
R4485 T5267 T5266 pobj astrocytes,of
R4486 T5268 T5265 prep from,NF-κB
R4487 T5269 T5270 compound Nrf2,WT
R4488 T5270 T5268 pobj WT,from
R4489 T5271 T5270 cc or,WT
R4490 T5272 T5270 conj KO,WT
R4491 T5273 T5264 pobj mice,of
R4492 T5274 T5260 prep by,studied
R4493 T5275 T5274 pobj EMSA,by
R4494 T5276 T5260 prep at,studied
R4495 T5277 T5278 nummod 24,h
R4496 T5278 T5276 pobj h,at
R4497 T5279 T5260 prep after,studied
R4498 T5280 T5281 compound scratch,injury
R4499 T5281 T5279 pobj injury,after
R4500 T5282 T5260 punct .,studied
R4501 T5283 T5285 advmod Scratch,induced
R4502 T5284 T5285 nsubj injury,induced
R4503 T5285 T5285 ROOT induced,induced
R4504 T5286 T5285 dobj activation,induced
R4505 T5287 T5286 prep of,activation
R4506 T5288 T5287 pobj NF-κB,of
R4507 T5289 T5286 prep in,activation
R4508 T5290 T5289 pobj astrocytes,in
R4509 T5291 T5290 prep of,astrocytes
R4510 T5292 T5293 det both,genotypes
R4511 T5293 T5291 pobj genotypes,of
R4512 T5294 T5285 punct ",",induced
R4513 T5295 T5300 mark while,observed
R4514 T5296 T5298 amod higher,activity
R4515 T5297 T5298 compound NF-κB,activity
R4516 T5298 T5300 nsubjpass activity,observed
R4517 T5299 T5300 auxpass was,observed
R4518 T5300 T5285 advcl observed,induced
R4519 T5301 T5300 prep in,observed
R4520 T5302 T5304 compound group,TBI
R4521 T5303 T5304 compound KO,TBI
R4522 T5304 T5301 pobj TBI,in
R4523 T5305 T5300 prep than,observed
R4524 T5306 T5305 prep in,than
R4525 T5307 T5309 compound group,TBI
R4526 T5308 T5309 compound WT,TBI
R4527 T5309 T5306 pobj TBI,in
R4528 T5310 T5309 punct (,TBI
R4529 T5311 T5312 nummod 2.67,±
R4530 T5312 T5320 dep ±,<
R4531 T5313 T5320 dep 0.173,<
R4532 T5314 T5320 prep versus,<
R4533 T5315 T5316 nummod 2.28,±
R4534 T5316 T5314 pobj ±,versus
R4535 T5317 T5316 appos 0.072,±
R4536 T5318 T5320 punct ",",<
R4537 T5319 T5320 nsubj P,<
R4538 T5320 T5320 ROOT <,<
R4539 T5321 T5320 npadvmod 0.01,<
R4540 T5322 T5320 punct ),<
R4541 T5323 T5324 punct (,Figure
R4542 T5324 T5320 appos Figure,<
R4543 T5325 T5324 nummod 2,Figure
R4544 T5326 T5324 punct ),Figure
R4545 T5327 T5320 punct .,<
R4966 T5946 T5946 ROOT 3.3,3.3
R4967 T5947 T5946 punct .,3.3
R4968 T5948 T5952 nsubj Expression,Was
R4969 T5949 T5948 prep of,Expression
R4970 T5950 T5951 compound Proinflammatory,Cytokines
R4971 T5951 T5949 pobj Cytokines,of
R4972 T5952 T5952 ROOT Was,Was
R4973 T5953 T5952 attr Elevated,Was
R4974 T5954 T5953 prep in,Elevated
R4975 T5955 T5956 compound Nrf2,Knockout
R4976 T5956 T5954 pobj Knockout,in
R4977 T5957 T5953 conj Astrocytes,Elevated
R4978 T5958 T5952 prep after,Was
R4979 T5959 T5960 compound Scratch,Injury
R4980 T5960 T5958 pobj Injury,after
R4981 T5961 T5964 mark As,know
R4982 T5962 T5964 nsubj we,know
R4983 T5963 T5962 appos all,we
R4984 T5964 T5973 advcl know,regulated
R4985 T5965 T5973 punct ",",regulated
R4986 T5966 T5973 nsubjpass TNF-α,regulated
R4987 T5967 T5966 punct ",",TNF-α
R4988 T5968 T5966 conj IL-1β,TNF-α
R4989 T5969 T5968 punct ",",IL-1β
R4990 T5970 T5968 cc and,IL-1β
R4991 T5971 T5968 conj IL-6,IL-1β
R4992 T5972 T5973 auxpass are,regulated
R4993 T5973 T5973 ROOT regulated,regulated
R4994 T5974 T5973 agent by,regulated
R4995 T5975 T5974 pobj NF-κB,by
R4996 T5976 T5973 cc and,regulated
R4997 T5977 T5973 conj reflect,regulated
R4998 T5978 T5980 det the,activity
R4999 T5979 T5980 amod endogenous,activity
R5000 T5980 T5977 dobj activity,reflect
R5001 T5981 T5980 prep of,activity
R5002 T5982 T5981 pobj NF-κB,of
R5003 T5983 T5973 punct .,regulated
R5004 T5984 T5987 nsubjpass It,revealed
R5005 T5985 T5987 aux has,revealed
R5006 T5986 T5987 auxpass been,revealed
R5007 T5987 T5987 ROOT revealed,revealed
R5008 T5988 T5993 mark that,increased
R5009 T5989 T5991 det these,cytokines
R5010 T5990 T5991 amod proinflammatory,cytokines
R5011 T5991 T5993 nsubjpass cytokines,increased
R5012 T5992 T5993 auxpass are,increased
R5013 T5993 T5987 ccomp increased,revealed
R5014 T5994 T5993 prep after,increased
R5015 T5995 T5994 pobj TBI,after
R5016 T5996 T5993 prep in,increased
R5017 T5997 T5996 pobj animals,in
R5018 T5998 T5993 conj [,increased
R5019 T5999 T5998 nummod 2,[
R5020 T6000 T5998 punct ",",[
R5021 T6001 T6002 nummod 8,]
R5022 T6002 T5998 appos ],[
R5023 T6003 T5987 punct .,revealed
R5024 T6004 T6009 cc And,proved
R5025 T6005 T6007 poss our,study
R5026 T6006 T6007 amod previous,study
R5027 T6007 T6009 nsubj study,proved
R5028 T6008 T6009 aux has,proved
R5029 T6009 T6009 ROOT proved,proved
R5030 T6010 T6018 mark that,observed
R5031 T6011 T6012 amod higher,levels
R5032 T6012 T6018 nsubjpass levels,observed
R5033 T6013 T6012 prep of,levels
R5034 T6014 T6016 amod such,cytokines
R5035 T6015 T6016 amod proinflammatory,cytokines
R5036 T6016 T6013 pobj cytokines,of
R5037 T6017 T6018 auxpass were,observed
R5038 T6018 T6009 ccomp observed,proved
R5039 T6019 T6018 prep in,observed
R5040 T6020 T6021 det the,brain
R5041 T6021 T6019 pobj brain,in
R5042 T6022 T6021 prep of,brain
R5043 T6023 T6024 amod Nrf2-deficient,mice
R5044 T6024 T6022 pobj mice,of
R5045 T6025 T6018 prep after,observed
R5046 T6026 T6029 nmod TBI,]
R5047 T6027 T6029 nmod [,]
R5048 T6028 T6029 nummod 5,]
R5049 T6029 T6025 pobj ],after
R5050 T6030 T6009 punct .,proved
R5051 T6031 T6033 cc But,is
R5052 T6032 T6033 nsubj it,is
R5053 T6033 T6033 ROOT is,is
R5054 T6034 T6033 advmod still,is
R5055 T6035 T6033 acomp ambiguous,is
R5056 T6036 T6035 prep about,ambiguous
R5057 T6037 T6038 det the,relationship
R5058 T6038 T6036 pobj relationship,about
R5059 T6039 T6038 prep between,relationship
R5060 T6040 T6041 det these,cytokines
R5061 T6041 T6039 pobj cytokines,between
R5062 T6042 T6041 cc and,cytokines
R5063 T6043 T6041 conj Nrf2,cytokines
R5064 T6044 T6038 prep in,relationship
R5065 T6045 T6044 pobj astrocytes,in
R5066 T6046 T6038 prep after,relationship
R5067 T6047 T6046 pobj TBI,after
R5068 T6048 T6033 punct .,is
R5069 T6049 T6052 advmod Here,tested
R5070 T6050 T6052 punct ",",tested
R5071 T6051 T6052 nsubj we,tested
R5072 T6052 T6052 ROOT tested,tested
R5073 T6053 T6054 det the,levels
R5074 T6054 T6052 dobj levels,tested
R5075 T6055 T6054 prep of,levels
R5076 T6056 T6055 pobj TNF-α,of
R5077 T6057 T6056 punct ",",TNF-α
R5078 T6058 T6056 conj IL-1β,TNF-α
R5079 T6059 T6058 punct ",",IL-1β
R5080 T6060 T6058 cc and,IL-1β
R5081 T6061 T6058 conj IL-6,IL-1β
R5082 T6062 T6054 prep in,levels
R5083 T6063 T6064 amod cultured,astrocytes
R5084 T6064 T6062 pobj astrocytes,in
R5085 T6065 T6052 prep at,tested
R5086 T6066 T6067 nummod 24,h
R5087 T6067 T6065 pobj h,at
R5088 T6068 T6052 prep after,tested
R5089 T6069 T6070 compound scratch,injury
R5090 T6070 T6068 pobj injury,after
R5091 T6071 T6070 prep by,injury
R5092 T6072 T6071 pobj RT-PCR,by
R5093 T6073 T6072 cc and,RT-PCR
R5094 T6074 T6072 conj ELISA,RT-PCR
R5095 T6075 T6052 punct .,tested
R5096 T6076 T6078 nsubjpass It,shown
R5097 T6077 T6078 auxpass was,shown
R5098 T6078 T6078 ROOT shown,shown
R5099 T6079 T6091 mark that,increased
R5100 T6080 T6082 det the,levels
R5101 T6081 T6082 amod mRNA,levels
R5102 T6082 T6091 nsubjpass levels,increased
R5103 T6083 T6082 prep of,levels
R5104 T6084 T6083 pobj TNF-α,of
R5105 T6085 T6084 punct ",",TNF-α
R5106 T6086 T6084 conj IL-1β,TNF-α
R5107 T6087 T6086 punct ",",IL-1β
R5108 T6088 T6086 cc and,IL-1β
R5109 T6089 T6086 conj IL-6,IL-1β
R5110 T6090 T6091 auxpass were,increased
R5111 T6091 T6078 ccomp increased,shown
R5112 T6092 T6091 prep after,increased
R5113 T6093 T6092 pobj scratch,after
R5114 T6094 T6093 prep in,scratch
R5115 T6095 T6096 det both,WT
R5116 T6096 T6094 pobj WT,in
R5117 T6097 T6096 cc and,WT
R5118 T6098 T6096 conj KO,WT
R5119 T6099 T6091 advmod astrocytes,increased
R5120 T6100 T6101 advmod when,compared
R5121 T6101 T6099 advcl compared,astrocytes
R5122 T6102 T6101 prep with,compared
R5123 T6103 T6105 poss their,counterparts
R5124 T6104 T6105 amod sham,counterparts
R5125 T6105 T6102 pobj counterparts,with
R5126 T6106 T6105 punct ",",counterparts
R5127 T6107 T6101 advmod respectively,compared
R5128 T6108 T6078 punct .,shown
R5129 T6109 T6121 advmod Moreover,were
R5130 T6110 T6121 punct ",",were
R5131 T6111 T6113 det the,levels
R5132 T6112 T6113 amod mRNA,levels
R5133 T6113 T6121 nsubj levels,were
R5134 T6114 T6113 prep of,levels
R5135 T6115 T6116 det these,cytokines
R5136 T6116 T6114 pobj cytokines,of
R5137 T6117 T6113 prep in,levels
R5138 T6118 T6117 pobj group,in
R5139 T6119 T6120 compound KO,TBI
R5140 T6120 T6121 nsubj TBI,were
R5141 T6121 T6121 ROOT were,were
R5142 T6122 T6123 advmod much,higher
R5143 T6123 T6121 acomp higher,were
R5144 T6124 T6123 prep than,higher
R5145 T6125 T6124 pobj those,than
R5146 T6126 T6125 prep in,those
R5147 T6127 T6129 compound group,TBI
R5148 T6128 T6129 compound WT,TBI
R5149 T6129 T6126 pobj TBI,in
R5150 T6130 T6129 punct (,TBI
R5151 T6131 T6132 nummod 1.66,±
R5152 T6132 T6137 nummod ±,0.110
R5153 T6133 T6137 nummod 0.085,0.110
R5154 T6134 T6133 prep versus,0.085
R5155 T6135 T6136 nummod 1.39,±
R5156 T6136 T6134 pobj ±,versus
R5157 T6137 T6129 appos 0.110,TBI
R5158 T6138 T6137 prep for,0.110
R5159 T6139 T6138 pobj TNF-α,for
R5160 T6140 T6139 punct ",",TNF-α
R5161 T6141 T6142 nummod 1.34,±
R5162 T6142 T6139 appos ±,TNF-α
R5163 T6143 T6142 conj 0.064,±
R5164 T6144 T6143 prep versus,0.064
R5165 T6145 T6147 nummod 0.73,0.088
R5166 T6146 T6147 nummod ±,0.088
R5167 T6147 T6144 pobj 0.088,versus
R5168 T6148 T6147 prep for,0.088
R5169 T6149 T6148 pobj IL-1β,for
R5170 T6150 T6139 punct ",",TNF-α
R5171 T6151 T6129 cc and,TBI
R5172 T6152 T6153 nummod 1.28,±
R5173 T6153 T6155 npadvmod ±,versus
R5174 T6154 T6155 nummod 0.102,versus
R5175 T6155 T6121 prep versus,were
R5176 T6156 T6158 nummod 0.99,0.073
R5177 T6157 T6158 nummod ±,0.073
R5178 T6158 T6155 pobj 0.073,versus
R5179 T6159 T6158 prep for,0.073
R5180 T6160 T6159 pobj IL-6,for
R5181 T6161 T6121 punct .,were
R5182 T6162 T6163 compound P,<
R5183 T6163 T6163 ROOT <,<
R5184 T6164 T6163 appos 0.01,<
R5185 T6165 T6163 punct ),<
R5186 T6166 T6167 punct (,Figures
R5187 T6167 T6163 appos Figures,<
R5188 T6168 T6167 nummod 3,Figures
R5189 T6169 T6170 punct (,a
R5190 T6170 T6167 parataxis a,Figures
R5191 T6171 T6170 punct ),a
R5192 T6172 T6170 meta 3,a
R5193 T6173 T6174 punct (,d
R5194 T6174 T6172 parataxis d,3
R5195 T6175 T6174 punct ),d
R5196 T6176 T6174 punct ),d
R5197 T6177 T6170 punct .,a
R5198 T6178 T6179 det The,results
R5199 T6179 T6182 nsubj results,revealed
R5200 T6180 T6179 prep of,results
R5201 T6181 T6180 pobj ELISA,of
R5202 T6182 T6182 ROOT revealed,revealed
R5203 T6183 T6189 mark that,was
R5204 T6184 T6186 det the,level
R5205 T6185 T6186 compound protein,level
R5206 T6186 T6189 nsubj level,was
R5207 T6187 T6186 prep of,level
R5208 T6188 T6187 pobj TNF-α,of
R5209 T6189 T6182 ccomp was,revealed
R5210 T6190 T6189 acomp upregulated,was
R5211 T6191 T6190 prep after,upregulated
R5212 T6192 T6193 compound scratch,injury
R5213 T6193 T6191 pobj injury,after
R5214 T6194 T6193 prep in,injury
R5215 T6195 T6194 pobj WT,in
R5216 T6196 T6195 cc and,WT
R5217 T6197 T6195 conj KO,WT
R5218 T6198 T6189 npadvmod astrocytes,was
R5219 T6199 T6200 advmod when,compared
R5220 T6200 T6189 prep compared,was
R5221 T6201 T6200 prep with,compared
R5222 T6202 T6204 poss their,counterparts
R5223 T6203 T6204 amod sham,counterparts
R5224 T6204 T6201 pobj counterparts,with
R5225 T6205 T6182 punct .,revealed
R5226 T6206 T6208 cc And,was
R5227 T6207 T6208 nsubj it,was
R5228 T6208 T6230 ccomp was,<
R5229 T6209 T6208 advmod also,was
R5230 T6210 T6208 advmod higher,was
R5231 T6211 T6208 prep in,was
R5232 T6212 T6214 compound group,TBI
R5233 T6213 T6214 compound KO,TBI
R5234 T6214 T6211 pobj TBI,in
R5235 T6215 T6208 prep than,was
R5236 T6216 T6215 prep in,than
R5237 T6217 T6216 pobj group,in
R5238 T6218 T6219 compound WT,TBI
R5239 T6219 T6217 appos TBI,group
R5240 T6220 T6221 punct (,3.67
R5241 T6221 T6223 nummod 3.67,0.156
R5242 T6222 T6223 nummod ±,0.156
R5243 T6223 T6215 pobj 0.156,than
R5244 T6224 T6208 prep versus,was
R5245 T6225 T6226 nummod 2.31,±
R5246 T6226 T6227 nummod ±,0.087
R5247 T6227 T6224 pobj 0.087,versus
R5248 T6228 T6230 punct ",",<
R5249 T6229 T6230 nsubj P,<
R5250 T6230 T6230 ROOT <,<
R5251 T6231 T6230 npadvmod 0.01,<
R5252 T6232 T6230 punct ),<
R5253 T6233 T6234 punct (,Figure
R5254 T6234 T6237 nmod Figure,a
R5255 T6235 T6234 nummod 4,Figure
R5256 T6236 T6237 punct (,a
R5257 T6237 T6230 parataxis a,<
R5258 T6238 T6237 punct ),a
R5259 T6239 T6237 punct ),a
R5260 T6240 T6230 punct .,<
R5261 T6241 T6242 amod Similar,tendency
R5262 T6242 T6244 nsubjpass tendency,observed
R5263 T6243 T6244 auxpass was,observed
R5264 T6244 T6244 ROOT observed,observed
R5265 T6245 T6244 prep in,observed
R5266 T6246 T6247 compound protein,level
R5267 T6247 T6245 pobj level,in
R5268 T6248 T6247 prep of,level
R5269 T6249 T6248 pobj IL-6,of
R5270 T6250 T6249 cc and,IL-6
R5271 T6251 T6249 conj IL-1β,IL-6
R5272 T6252 T6244 punct .,observed
R5273 T6253 T6257 prep For,was
R5274 T6254 T6253 pobj IL-6,For
R5275 T6255 T6257 punct ",",was
R5276 T6256 T6257 nsubj it,was
R5277 T6257 T6257 ROOT was,was
R5278 T6258 T6260 nummod 36.07,0.786
R5279 T6259 T6260 nummod ±,0.786
R5280 T6260 T6257 attr 0.786,was
R5281 T6261 T6260 prep for,0.786
R5282 T6262 T6264 compound group,TBI
R5283 T6263 T6264 compound KO,TBI
R5284 T6264 T6261 pobj TBI,for
R5285 T6265 T6257 prep while,was
R5286 T6266 T6268 nummod 25.76,0.536
R5287 T6267 T6268 nummod ±,0.536
R5288 T6268 T6265 pobj 0.536,while
R5289 T6269 T6268 prep for,0.536
R5290 T6270 T6269 pobj group,for
R5291 T6271 T6272 compound WT,TBI
R5292 T6272 T6270 appos TBI,group
R5293 T6273 T6274 punct (,P
R5294 T6274 T6272 appos P,TBI
R5295 T6275 T6276 compound <,0.01
R5296 T6276 T6274 nummod 0.01,P
R5297 T6277 T6272 punct ),TBI
R5298 T6278 T6279 punct (,Figure
R5299 T6279 T6268 appos Figure,0.536
R5300 T6280 T6279 nummod 4,Figure
R5301 T6281 T6282 punct (,b
R5302 T6282 T6279 appos b,Figure
R5303 T6283 T6282 punct ),b
R5304 T6284 T6279 punct ),Figure
R5305 T6285 T6257 punct .,was
R5306 T6286 T6290 prep For,was
R5307 T6287 T6286 pobj IL-1β,For
R5308 T6288 T6290 punct ",",was
R5309 T6289 T6290 nsubj it,was
R5310 T6290 T6290 ROOT was,was
R5311 T6291 T6293 nummod 190.75,6.339
R5312 T6292 T6293 nummod ±,6.339
R5313 T6293 T6290 attr 6.339,was
R5314 T6294 T6293 prep for,6.339
R5315 T6295 T6297 compound group,TBI
R5316 T6296 T6297 compound KO,TBI
R5317 T6297 T6294 pobj TBI,for
R5318 T6298 T6301 mark while,5.348
R5319 T6299 T6301 nummod 154.50,5.348
R5320 T6300 T6301 nummod ±,5.348
R5321 T6301 T6290 advcl 5.348,was
R5322 T6302 T6301 prep for,5.348
R5323 T6303 T6302 pobj group,for
R5324 T6304 T6305 compound WT,TBI
R5325 T6305 T6303 appos TBI,group
R5326 T6306 T6307 punct (,P
R5327 T6307 T6305 appos P,TBI
R5328 T6308 T6309 compound <,0.01
R5329 T6309 T6307 nummod 0.01,P
R5330 T6310 T6305 punct ),TBI
R5331 T6311 T6312 punct (,Figure
R5332 T6312 T6315 nmod Figure,c
R5333 T6313 T6312 nummod 4,Figure
R5334 T6314 T6315 punct (,c
R5335 T6315 T6303 appos c,group
R5336 T6316 T6315 punct ),c
R5337 T6317 T6301 punct ),5.348
R5338 T6318 T6290 punct .,was
R5596 T6759 T6759 ROOT 3.4,3.4
R5597 T6760 T6759 punct .,3.4
R5598 T6761 T6768 nsubjpass Expression,Enhanced
R5599 T6762 T6761 cc and,Expression
R5600 T6763 T6761 conj Activity,Expression
R5601 T6764 T6763 prep of,Activity
R5602 T6765 T6764 pobj MMP9,of
R5603 T6766 T6768 auxpass Were,Enhanced
R5604 T6767 T6768 advmod Greatly,Enhanced
R5605 T6768 T6768 ROOT Enhanced,Enhanced
R5606 T6769 T6768 prep in,Enhanced
R5607 T6770 T6772 compound Nrf2,Astrocytes
R5608 T6771 T6772 compound Knockout,Astrocytes
R5609 T6772 T6769 pobj Astrocytes,in
R5610 T6773 T6777 mark after,is
R5611 T6774 T6776 compound Scratch,MMP9
R5612 T6775 T6776 compound Injury,MMP9
R5613 T6776 T6777 nsubj MMP9,is
R5614 T6777 T6768 advcl is,Enhanced
R5615 T6778 T6780 det an,gelatinase
R5616 T6779 T6780 amod important,gelatinase
R5617 T6780 T6777 attr gelatinase,is
R5618 T6781 T6782 aux to,induce
R5619 T6782 T6780 relcl induce,gelatinase
R5620 T6783 T6782 cc or,induce
R5621 T6784 T6782 conj aggravate,induce
R5622 T6785 T6787 det the,process
R5623 T6786 T6787 compound inflammation,process
R5624 T6787 T6784 dobj process,aggravate
R5625 T6788 T6768 punct .,Enhanced
R5626 T6789 T6795 prep In,elevated
R5627 T6790 T6792 det the,study
R5628 T6791 T6792 amod present,study
R5629 T6792 T6789 pobj study,In
R5630 T6793 T6795 punct ",",elevated
R5631 T6794 T6795 nsubj we,elevated
R5632 T6795 T6795 ROOT elevated,elevated
R5633 T6796 T6797 det the,mRNA
R5634 T6797 T6795 dobj mRNA,elevated
R5635 T6798 T6797 punct ",",mRNA
R5636 T6799 T6800 compound protein,levels
R5637 T6800 T6797 conj levels,mRNA
R5638 T6801 T6800 punct ",",levels
R5639 T6802 T6800 cc and,levels
R5640 T6803 T6800 conj activity,levels
R5641 T6804 T6803 prep of,activity
R5642 T6805 T6804 pobj MMP9,of
R5643 T6806 T6803 prep in,activity
R5644 T6807 T6806 pobj astrocytes,in
R5645 T6808 T6795 prep at,elevated
R5646 T6809 T6810 nummod 24,h
R5647 T6810 T6808 pobj h,at
R5648 T6811 T6795 prep after,elevated
R5649 T6812 T6813 compound scratch,injury
R5650 T6813 T6811 pobj injury,after
R5651 T6814 T6813 prep by,injury
R5652 T6815 T6814 pobj RT-PCR,by
R5653 T6816 T6815 punct ",",RT-PCR
R5654 T6817 T6818 amod western,blot
R5655 T6818 T6815 appos blot,RT-PCR
R5656 T6819 T6815 punct ",",RT-PCR
R5657 T6820 T6815 cc and,RT-PCR
R5658 T6821 T6822 compound gelatine,zymography
R5659 T6822 T6813 conj zymography,injury
R5660 T6823 T6795 punct .,elevated
R5661 T6824 T6828 nsubjpass Expression,elevated
R5662 T6825 T6824 prep of,Expression
R5663 T6826 T6825 pobj MMP9,of
R5664 T6827 T6828 auxpass was,elevated
R5665 T6828 T6828 ROOT elevated,elevated
R5666 T6829 T6828 prep after,elevated
R5667 T6830 T6831 compound scratch,injury
R5668 T6831 T6829 pobj injury,after
R5669 T6832 T6831 prep in,injury
R5670 T6833 T6832 pobj WT,in
R5671 T6834 T6833 cc and,WT
R5672 T6835 T6833 conj KO,WT
R5673 T6836 T6828 npadvmod astrocytes,elevated
R5674 T6837 T6828 prep as,elevated
R5675 T6838 T6837 prep compared,as
R5676 T6839 T6838 prep with,compared
R5677 T6840 T6842 poss their,counterparts
R5678 T6841 T6842 amod sham,counterparts
R5679 T6842 T6839 pobj counterparts,with
R5680 T6843 T6828 punct .,elevated
R5681 T6844 T6846 det The,level
R5682 T6845 T6846 amod mRNA,level
R5683 T6846 T6849 nsubj level,was
R5684 T6847 T6846 prep of,level
R5685 T6848 T6847 pobj MMP9,of
R5686 T6849 T6849 ROOT was,was
R5687 T6850 T6849 acomp higher,was
R5688 T6851 T6849 prep in,was
R5689 T6852 T6854 compound group,TBI
R5690 T6853 T6854 compound KO,TBI
R5691 T6854 T6851 pobj TBI,in
R5692 T6855 T6849 prep than,was
R5693 T6856 T6855 prep in,than
R5694 T6857 T6859 compound group,TBI
R5695 T6858 T6859 compound WT,TBI
R5696 T6859 T6856 pobj TBI,in
R5697 T6860 T6859 punct (,TBI
R5698 T6861 T6862 nummod 1.36,±
R5699 T6862 T6870 nummod ±,<
R5700 T6863 T6870 dep 0.090,<
R5701 T6864 T6870 prep versus,<
R5702 T6865 T6866 nummod 1.01,±
R5703 T6866 T6867 nummod ±,0.068
R5704 T6867 T6864 pobj 0.068,versus
R5705 T6868 T6870 punct ",",<
R5706 T6869 T6870 nsubj P,<
R5707 T6870 T6859 appos <,TBI
R5708 T6871 T6870 npadvmod 0.01,<
R5709 T6872 T6870 punct ),<
R5710 T6873 T6859 punct (,TBI
R5711 T6874 T6873 dep Figures,(
R5712 T6875 T6874 nummod 3,Figures
R5713 T6876 T6877 punct (,a
R5714 T6877 T6875 parataxis a,3
R5715 T6878 T6877 punct ),a
R5716 T6879 T6875 cc and,3
R5717 T6880 T6875 conj 3,3
R5718 T6881 T6882 punct (,e
R5719 T6882 T6874 parataxis e,Figures
R5720 T6883 T6882 punct ),e
R5721 T6884 T6882 punct ),e
R5722 T6885 T6874 punct .,Figures
R5723 T6886 T6887 amod Significant,difference
R5724 T6887 T6890 nsubjpass difference,discovered
R5725 T6888 T6890 auxpass was,discovered
R5726 T6889 T6890 advmod also,discovered
R5727 T6890 T6890 ROOT discovered,discovered
R5728 T6891 T6890 prep in,discovered
R5729 T6892 T6894 nummod MMP9,level
R5730 T6893 T6894 compound protein,level
R5731 T6894 T6891 pobj level,in
R5732 T6895 T6890 agent by,discovered
R5733 T6896 T6897 amod western,blot
R5734 T6897 T6895 pobj blot,by
R5735 T6898 T6890 punct ",",discovered
R5736 T6899 T6890 prep as,discovered
R5737 T6900 T6901 nummod 1.44,±
R5738 T6901 T6902 compound ±,0.076
R5739 T6902 T6899 pobj 0.076,as
R5740 T6903 T6902 prep for,0.076
R5741 T6904 T6906 compound group,TBI
R5742 T6905 T6906 compound KO,TBI
R5743 T6906 T6903 pobj TBI,for
R5744 T6907 T6902 cc and,0.076
R5745 T6908 T6909 nummod 1.13,±
R5746 T6909 T6902 conj ±,0.076
R5747 T6910 T6909 conj 0.048,±
R5748 T6911 T6910 prep for,0.048
R5749 T6912 T6911 pobj group,for
R5750 T6913 T6914 compound WT,TBI
R5751 T6914 T6912 appos TBI,group
R5752 T6915 T6916 punct (,P
R5753 T6916 T6914 appos P,TBI
R5754 T6917 T6918 compound <,0.01
R5755 T6918 T6916 nummod 0.01,P
R5756 T6919 T6914 punct ),TBI
R5757 T6920 T6921 punct (,Figure
R5758 T6921 T6912 appos Figure,group
R5759 T6922 T6921 nummod 5,Figure
R5760 T6923 T6921 punct ),Figure
R5761 T6924 T6890 punct .,discovered
R5762 T6925 T6926 compound Gelatine,zymography
R5763 T6926 T6927 nsubj zymography,revealed
R5764 T6927 T6927 ROOT revealed,revealed
R5765 T6928 T6930 amod higher,activity
R5766 T6929 T6930 compound MMP9,activity
R5767 T6930 T6927 dobj activity,revealed
R5768 T6931 T6930 prep in,activity
R5769 T6932 T6934 compound group,TBI
R5770 T6933 T6934 compound KO,TBI
R5771 T6934 T6931 pobj TBI,in
R5772 T6935 T6930 prep than,activity
R5773 T6936 T6935 pobj that,than
R5774 T6937 T6936 prep in,that
R5775 T6938 T6940 compound group,TBI
R5776 T6939 T6940 compound WT,TBI
R5777 T6940 T6937 pobj TBI,in
R5778 T6941 T6927 advmod too,revealed
R5779 T6942 T6927 punct (,revealed
R5780 T6943 T6944 nummod 101.76,±
R5781 T6944 T6945 nummod ±,6.343
R5782 T6945 T6927 npadvmod 6.343,revealed
R5783 T6946 T6945 prep versus,6.343
R5784 T6947 T6949 nummod 76.32,3.388
R5785 T6948 T6949 nummod ±,3.388
R5786 T6949 T6946 pobj 3.388,versus
R5787 T6950 T6952 punct ",",<
R5788 T6951 T6952 nsubj P,<
R5789 T6952 T6952 ROOT <,<
R5790 T6953 T6952 npadvmod 0.01,<
R5791 T6954 T6952 punct ),<
R5792 T6955 T6956 punct (,Figure
R5793 T6956 T6952 appos Figure,<
R5794 T6957 T6956 nummod 6,Figure
R5795 T6958 T6956 punct ),Figure
R5796 T6959 T6952 punct .,<
R7071 T8743 T8745 det The,study
R7072 T8744 T8745 amod present,study
R7073 T8745 T8746 nsubj study,demonstrated
R7074 T8746 T8746 ROOT demonstrated,demonstrated
R7075 T8747 T8750 mark that,induced
R7076 T8748 T8749 compound scratch,injury
R7077 T8749 T8750 nsubj injury,induced
R7078 T8750 T8746 ccomp induced,demonstrated
R7079 T8751 T8752 det the,upregulation
R7080 T8752 T8750 dobj upregulation,induced
R7081 T8753 T8752 prep of,upregulation
R7082 T8754 T8755 compound NF-κB,DNA
R7083 T8755 T8753 pobj DNA,of
R7084 T8756 T8757 amod binding,activity
R7085 T8757 T8753 pobj activity,of
R7086 T8758 T8757 cc and,activity
R7087 T8759 T8757 conj overexpression,activity
R7088 T8760 T8759 prep of,overexpression
R7089 T8761 T8760 pobj TNF-α,of
R709 T917 T918 compound Brain,damage
R7090 T8762 T8761 punct ",",TNF-α
R7091 T8763 T8761 conj IL-1β,TNF-α
R7092 T8764 T8763 punct ",",IL-1β
R7093 T8765 T8763 conj IL-6,IL-1β
R7094 T8766 T8765 punct ",",IL-6
R7095 T8767 T8765 cc and,IL-6
R7096 T8768 T8765 conj MMP9,IL-6
R7097 T8769 T8752 prep in,upregulation
R7098 T8770 T8771 amod cultured,astrocytes
R7099 T8771 T8769 pobj astrocytes,in
R710 T918 T922 nsubj damage,is
R7100 T8772 T8746 punct .,demonstrated
R7101 T8773 T8775 advmod Also,revealed
R7102 T8774 T8775 nsubj we,revealed
R7103 T8775 T8775 ROOT revealed,revealed
R7104 T8776 T8779 mark that,induced
R7105 T8777 T8778 compound scratch,injury
R7106 T8778 T8779 nsubj injury,induced
R7107 T8779 T8775 ccomp induced,revealed
R7108 T8780 T8781 amod higher,activity
R7109 T8781 T8779 dobj activity,induced
R711 T919 T918 acl following,damage
R7110 T8782 T8781 prep of,activity
R7111 T8783 T8782 pobj NF-κB,of
R7112 T8784 T8781 cc and,activity
R7113 T8785 T8786 amod enhanced,expression
R7114 T8786 T8781 conj expression,activity
R7115 T8787 T8786 prep of,expression
R7116 T8788 T8789 amod proinflammatory,cytokines
R7117 T8789 T8787 pobj cytokines,of
R7118 T8790 T8789 prep in,cytokines
R7119 T8791 T8792 amod Nrf2,knockout
R712 T920 T921 amod traumatic,injury
R7120 T8792 T8790 pobj knockout,in
R7121 T8793 T8779 conj cultured,induced
R7122 T8794 T8793 dobj astrocytes,cultured
R7123 T8795 T8794 prep than,astrocytes
R7124 T8796 T8795 pobj those,than
R7125 T8797 T8796 prep in,those
R7126 T8798 T8799 compound wildtype,astrocytes
R7127 T8799 T8797 pobj astrocytes,in
R7128 T8800 T8793 prep for,cultured
R7129 T8801 T8803 det the,time
R713 T921 T919 dobj injury,following
R7130 T8802 T8803 amod first,time
R7131 T8803 T8800 pobj time,for
R7132 T8804 T8775 punct .,revealed
R7133 T8805 T8808 nsubjpass It,demonstrated
R7134 T8806 T8808 aux has,demonstrated
R7135 T8807 T8808 auxpass been,demonstrated
R7136 T8808 T8808 ROOT demonstrated,demonstrated
R7137 T8809 T8812 mark that,activated
R7138 T8810 T8812 nsubjpass NF-κB,activated
R7139 T8811 T8812 auxpass is,activated
R714 T922 T922 ROOT is,is
R7140 T8812 T8808 ccomp activated,demonstrated
R7141 T8813 T8812 prep in,activated
R7142 T8814 T8813 pobj brain,in
R7143 T8815 T8814 cc and,brain
R7144 T8816 T8817 amod spinal,cord
R7145 T8817 T8814 conj cord,brain
R7146 T8818 T8812 prep after,activated
R7147 T8819 T8821 amod traumatic,[
R7148 T8820 T8821 compound injury,[
R7149 T8821 T8818 pobj [,after
R715 T923 T924 det a,result
R7150 T8822 T8821 nummod 2,[
R7151 T8823 T8821 punct ",",[
R7152 T8824 T8825 nummod 9,]
R7153 T8825 T8821 appos ],[
R7154 T8826 T8808 punct .,demonstrated
R7155 T8827 T8839 prep As,activated
R7156 T8828 T8830 det a,factor
R7157 T8829 T8830 compound transcript,factor
R7158 T8830 T8827 pobj factor,As
R7159 T8831 T8839 punct ",",activated
R716 T924 T922 attr result,is
R7160 T8832 T8833 amod NF-κB,binds
R7161 T8833 T8839 nsubjpass binds,activated
R7162 T8834 T8833 prep with,binds
R7163 T8835 T8834 pobj DNA,with
R7164 T8836 T8839 mark once,activated
R7165 T8837 T8839 nsubjpass it,activated
R7166 T8838 T8839 auxpass was,activated
R7167 T8839 T8839 ROOT activated,activated
R7168 T8840 T8839 cc and,activated
R7169 T8841 T8839 conj induces,activated
R717 T925 T924 prep of,result
R7170 T8842 T8841 dobj transcription,induces
R7171 T8843 T8842 prep of,transcription
R7172 T8844 T8843 pobj MMP9,of
R7173 T8845 T8842 cc and,transcription
R7174 T8846 T8847 det a,battery
R7175 T8847 T8842 conj battery,transcription
R7176 T8848 T8847 prep of,battery
R7177 T8849 T8850 amod proinflammatory,cytokines
R7178 T8850 T8848 pobj cytokines,of
R7179 T8851 T8850 punct ",",cytokines
R718 T926 T929 amod direct,injury
R7180 T8852 T8850 prep including,cytokines
R7181 T8853 T8852 pobj TNF-α,including
R7182 T8854 T8853 punct ",",TNF-α
R7183 T8855 T8853 conj IL-1β,TNF-α
R7184 T8856 T8855 punct ",",IL-1β
R7185 T8857 T8855 cc and,IL-1β
R7186 T8858 T8855 conj IL-6,IL-1β
R7187 T8859 T8850 punct ",",cytokines
R7188 T8860 T8847 prep in,battery
R7189 T8861 T8862 compound brain,tissues
R719 T927 T929 punct (,injury
R7190 T8862 T8860 pobj tissues,in
R7191 T8863 T8841 prep after,induces
R7192 T8864 T8865 compound TBI,[
R7193 T8865 T8863 pobj [,after
R7194 T8866 T8868 quantmod 3,10
R7195 T8867 T8868 punct ",",10
R7196 T8868 T8871 nummod 10,]
R7197 T8869 T8870 punct ",",11
R7198 T8870 T8871 nummod 11,]
R7199 T8871 T8865 appos ],[
R720 T928 T929 amod primary,injury
R7200 T8872 T8839 punct .,activated
R7201 T8873 T8874 poss Our,results
R7202 T8874 T8876 nsubj results,revealed
R7203 T8875 T8876 advmod also,revealed
R7204 T8876 T8876 ROOT revealed,revealed
R7205 T8877 T8880 mark that,induced
R7206 T8878 T8879 compound scratch,injury
R7207 T8879 T8880 nsubj injury,induced
R7208 T8880 T8876 ccomp induced,revealed
R7209 T8881 T8880 dobj elevation,induced
R721 T929 T939 nmod injury,mechanisms
R7210 T8882 T8881 prep of,elevation
R7211 T8883 T8884 compound NF-κB,DNA
R7212 T8884 T8882 pobj DNA,of
R7213 T8885 T8886 amod binding,activity
R7214 T8886 T8880 conj activity,induced
R7215 T8887 T8886 punct ",",activity
R7216 T8888 T8886 conj overexpression,activity
R7217 T8889 T8888 prep of,overexpression
R7218 T8890 T8889 pobj MMP9,of
R7219 T8891 T8888 punct ",",overexpression
R722 T930 T929 punct ),injury
R7220 T8892 T8888 cc and,overexpression
R7221 T8893 T8894 amod proinflammatory,mediators
R7222 T8894 T8888 conj mediators,overexpression
R7223 T8895 T8894 acl mentioned,mediators
R7224 T8896 T8895 advmod above,mentioned
R7225 T8897 T8895 prep in,mentioned
R7226 T8898 T8899 amod cultured,astrocytes
R7227 T8899 T8897 pobj astrocytes,in
R7228 T8900 T8876 punct .,revealed
R7229 T8901 T8904 nsubjpass It,demonstrated
R723 T931 T929 cc and,injury
R7230 T8902 T8904 aux has,demonstrated
R7231 T8903 T8904 auxpass been,demonstrated
R7232 T8904 T8904 ROOT demonstrated,demonstrated
R7233 T8905 T8907 mark that,is
R7234 T8906 T8907 expl there,is
R7235 T8907 T8904 ccomp is,demonstrated
R7236 T8908 T8910 det an,loop
R7237 T8909 T8910 amod autoregulatory,loop
R7238 T8910 T8907 attr loop,is
R7239 T8911 T8910 prep among,loop
R724 T932 T937 amod indirect,injury
R7240 T8912 T8914 det these,mediators
R7241 T8913 T8914 amod proinflammatory,mediators
R7242 T8914 T8911 pobj mediators,among
R7243 T8915 T8904 punct .,demonstrated
R7244 T8916 T8922 prep For,are
R7245 T8917 T8916 pobj example,For
R7246 T8918 T8922 punct ",",are
R7247 T8919 T8922 nsubj TNF-α,are
R7248 T8920 T8919 cc and,TNF-α
R7249 T8921 T8919 conj IL-1β,TNF-α
R725 T933 T937 punct (,injury
R7250 T8922 T8922 ROOT are,are
R7251 T8923 T8924 amod potent,stimulators
R7252 T8924 T8922 attr stimulators,are
R7253 T8925 T8924 prep for,stimulators
R7254 T8926 T8925 pobj MMP9,for
R7255 T8927 T8924 prep in,stimulators
R7256 T8928 T8927 pobj astrocytes,in
R7257 T8929 T8933 nmod [,]
R7258 T8930 T8933 nummod 12,]
R7259 T8931 T8933 punct ",",]
R726 T934 T937 amod secondary,injury
R7260 T8932 T8933 nummod 13,]
R7261 T8933 T8937 nsubj ],induces
R7262 T8934 T8933 punct ",",]
R7263 T8935 T8933 cc and,]
R7264 T8936 T8933 conj IL-6,]
R7265 T8937 T8937 ROOT induces,induces
R7266 T8938 T8937 dobj overexpression,induces
R7267 T8939 T8938 prep of,overexpression
R7268 T8940 T8939 pobj MMP9,of
R7269 T8941 T8938 prep in,overexpression
R727 T935 T934 cc or,secondary
R7270 T8942 T8944 amod human,carcinoma
R7271 T8943 T8944 compound colon,carcinoma
R7272 T8944 T8945 compound carcinoma,cells
R7273 T8945 T8941 pobj cells,in
R7274 T8946 T8948 nmod [,]
R7275 T8947 T8948 nummod 14,]
R7276 T8948 T8937 dobj ],induces
R7277 T8949 T8948 punct ",",]
R7278 T8950 T8948 cc and,]
R7279 T8951 T8948 conj TNF-α,]
R728 T936 T934 conj delayed,secondary
R7280 T8952 T8951 cc and,TNF-α
R7281 T8953 T8951 conj IL-1β,TNF-α
R7282 T8954 T8956 advmod also,induce
R7283 T8955 T8956 aux can,induce
R7284 T8956 T8937 conj induce,induces
R7285 T8957 T8956 dobj activation,induce
R7286 T8958 T8957 prep of,activation
R7287 T8959 T8960 compound NF-κB,[
R7288 T8960 T8958 pobj [,of
R7289 T8961 T8960 nummod 15,[
R729 T937 T929 conj injury,injury
R7290 T8962 T8960 punct ",",[
R7291 T8963 T8964 nummod 16,]
R7292 T8964 T8960 appos ],[
R7293 T8965 T8937 punct .,induces
R7294 T8966 T8968 det This,loop
R7295 T8967 T8968 amod autoregulatory,loop
R7296 T8968 T8970 nsubj loop,aggravates
R7297 T8969 T8970 advmod extremely,aggravates
R7298 T8970 T8970 ROOT aggravates,aggravates
R7299 T8971 T8973 det the,effect
R730 T938 T937 punct ),injury
R7300 T8972 T8973 amod damaging,effect
R7301 T8973 T8970 dobj effect,aggravates
R7302 T8974 T8973 prep of,effect
R7303 T8975 T8974 pobj inflammation,of
R7304 T8976 T8970 cc and,aggravates
R7305 T8977 T8970 conj induces,aggravates
R7306 T8978 T8979 amod secondary,injury
R7307 T8979 T8977 dobj injury,induces
R7308 T8980 T8977 prep to,induces
R7309 T8981 T8980 pobj brain,to
R731 T939 T925 pobj mechanisms,of
R7310 T8982 T8970 punct .,aggravates
R7311 T8983 T8984 nsubj It,is
R7312 T8984 T8984 ROOT is,is
R7313 T8985 T8987 det a,choice
R7314 T8986 T8987 amod good,choice
R7315 T8987 T8984 attr choice,is
R7316 T8988 T8987 prep for,choice
R7317 T8989 T8988 pcomp targeting,for
R7318 T8990 T8989 prep on,targeting
R7319 T8991 T8993 det an,factor
R732 T940 T922 punct .,is
R7320 T8992 T8993 amod upstream,factor
R7321 T8993 T8990 pobj factor,on
R7322 T8994 T8995 aux to,prevent
R7323 T8995 T8993 acl prevent,factor
R7324 T8996 T8998 amod such,loop
R7325 T8997 T8998 amod autoregulatory,loop
R7326 T9025 T9024 punct ",",metabolites
R7327 T8998 T8995 dobj loop,prevent
R7328 T9026 T9029 nsubjpass which,involved
R7329 T9027 T9029 auxpass are,involved
R733 T941 T944 det The,mechanism
R7330 T8999 T8998 prep after,loop
R7331 T9028 T9029 dep all,involved
R7332 T9029 T9024 relcl involved,metabolites
R7333 T9000 T8999 pobj TBI,after
R7334 T9030 T9029 prep in,involved
R7335 T9031 T9030 pobj TBI,in
R7336 T9001 T8984 punct .,is
R7337 T9032 T9006 punct .,proved
R7338 T9033 T9035 poss Our,study
R7339 T9002 T9003 amod Nrf2-ARE,pathway
R734 T942 T944 amod secondary,mechanism
R7340 T9034 T9035 amod previous,study
R7341 T9035 T9037 nsubj study,proved
R7342 T9036 T9037 aux has,proved
R7343 T9003 T9006 nsubjpass pathway,proved
R7344 T9037 T9037 ROOT proved,proved
R7345 T9038 T9039 det the,augmentation
R7346 T9039 T9037 dobj augmentation,proved
R7347 T9004 T9006 aux has,proved
R7348 T9040 T9039 prep of,augmentation
R7349 T9041 T9040 pobj Nrf2,of
R735 T943 T944 compound injury,mechanism
R7350 T9042 T9039 prep in,augmentation
R7351 T9005 T9006 auxpass been,proved
R7352 T9043 T9044 compound brain,tissue
R7353 T9044 T9042 pobj tissue,in
R7354 T9045 T9037 prep after,proved
R7355 T9006 T9006 ROOT proved,proved
R7356 T9046 T9047 compound TBI,[
R7357 T9047 T9045 pobj [,after
R7358 T9007 T9008 aux to,be
R7359 T9048 T9047 nummod 17,[
R736 T944 T945 nsubj mechanism,involves
R7360 T9049 T9047 conj ],[
R7361 T9008 T9006 xcomp be,proved
R7362 T9050 T9037 punct .,proved
R7363 T9051 T9052 amod Enhanced,level
R7364 T9052 T9052 ROOT level,level
R7365 T9009 T9011 det the,regulator
R7366 T9053 T9052 prep of,level
R7367 T9010 T9011 amod key,regulator
R7368 T9054 T9055 amod Nrf2,activates
R7369 T9055 T9053 pobj activates,of
R737 T945 T945 ROOT involves,involves
R7370 T9056 T9055 dobj transcription,activates
R7371 T9011 T9008 attr regulator,be
R7372 T9057 T9056 prep of,transcription
R7373 T9058 T9059 det a,group
R7374 T9012 T9011 prep in,regulator
R7375 T9013 T9012 pcomp reducing,in
R7376 T9014 T9015 amod oxidative,stress
R7377 T9015 T9013 dobj stress,reducing
R7378 T9016 T9015 punct ",",stress
R7379 T9059 T9057 pobj group,of
R738 T946 T947 det the,initiation
R7380 T9060 T9059 prep of,group
R7381 T9017 T9018 amod inflammatory,damage
R7382 T9061 T9062 amod antioxidant,genes
R7383 T9062 T9060 pobj genes,of
R7384 T9063 T9062 punct ",",genes
R7385 T9018 T9015 conj damage,stress
R7386 T9064 T9065 amod such,as
R7387 T9065 T9062 prep as,genes
R7388 T9019 T9018 punct ",",damage
R7389 T9066 T9067 compound heme,oxygenase-1
R739 T947 T945 dobj initiation,involves
R7390 T9020 T9018 cc and,damage
R7391 T9021 T9018 conj accumulation,damage
R7392 T9067 T9065 pobj oxygenase-1,as
R7393 T9068 T9069 punct (,HO-1
R7394 T9022 T9021 prep of,accumulation
R7395 T9069 T9067 appos HO-1,oxygenase-1
R7396 T9070 T9069 punct ),HO-1
R7397 T9071 T9067 cc and,oxygenase-1
R7398 T9023 T9024 amod toxic,metabolites
R7399 T9072 T9067 conj NAD,oxygenase-1
R740 T948 T947 prep of,initiation
R7400 T9073 T9072 punct (,NAD
R7401 T9024 T9022 pobj metabolites,of
R7402 T9074 T9072 appos P,NAD
R7403 T9075 T9072 punct ),NAD
R7404 T9156 T9159 nsubj Depletion,induces
R7405 T9076 T9065 pobj H,as
R7406 T9077 T9055 punct :,activates
R7407 T9078 T9079 compound quinone,oxidoreductase-1
R7408 T9157 T9156 prep of,Depletion
R7409 T9079 T9052 appos oxidoreductase-1,level
R741 T949 T952 det an,response
R7410 T9080 T9079 punct (,oxidoreductase-1
R7411 T9081 T9079 appos NQO1,oxidoreductase-1
R7412 T9158 T9157 pobj Nrf2,of
R7413 T9082 T9079 punct ),oxidoreductase-1
R7414 T9083 T9052 punct ",",level
R7415 T9084 T9087 nsubj which,reduce
R7416 T9159 T9159 ROOT induces,induces
R7417 T9085 T9087 aux would,reduce
R7418 T9086 T9087 advmod subsequently,reduce
R7419 T9160 T9161 amod higher,expression
R742 T950 T952 amod acute,response
R7420 T9087 T9052 relcl reduce,level
R7421 T9088 T9089 det the,damage
R7422 T9089 T9087 dobj damage,reduce
R7423 T9090 T9089 prep in,damage
R7424 T9091 T9090 pobj brain,in
R7425 T9161 T9159 dobj expression,induces
R7426 T9092 T9094 nmod [,]
R7427 T9093 T9094 nummod 18,]
R7428 T9094 T9089 appos ],damage
R7429 T9095 T9052 punct .,level
R743 T951 T952 amod inflammatory,response
R7430 T9096 T9097 compound Postinjury,administration
R7431 T9162 T9161 prep of,expression
R7432 T9097 T9107 nsubj administration,improves
R7433 T9098 T9097 prep of,administration
R7434 T9099 T9098 pobj SFN,of
R7435 T9163 T9164 amod proinflammatory,mediators
R7436 T9100 T9099 punct ",",SFN
R7437 T9164 T9162 pobj mediators,of
R7438 T9101 T9102 det an,inducer
R7439 T9102 T9099 appos inducer,SFN
R744 T952 T948 pobj response,of
R7440 T9165 T9159 prep in,induces
R7441 T9103 T9102 prep of,inducer
R7442 T9104 T9103 pobj Nrf2,of
R7443 T9105 T9107 punct ",",improves
R7444 T9166 T9165 pobj brain,in
R7445 T9106 T9107 advmod significantly,improves
R7446 T9107 T9107 ROOT improves,improves
R7447 T9108 T9109 amod spatial,memory
R7448 T9167 T9159 prep after,induces
R7449 T9109 T9107 dobj memory,improves
R745 T953 T947 punct ",",initiation
R7450 T9110 T9109 prep of,memory
R7451 T9111 T9110 pobj rat,of
R7452 T9168 T9169 compound TBI,[
R7453 T9112 T9107 cc and,improves
R7454 T9113 T9107 conj decreases,improves
R7455 T9114 T9115 det the,immunoreactivity
R7456 T9169 T9171 nmod [,]
R7457 T9115 T9113 dobj immunoreactivity,decreases
R7458 T9116 T9115 prep for,immunoreactivity
R7459 T9117 T9116 pobj 4-Hydroxynonenal,for
R746 T954 T947 prep including,initiation
R7460 T9170 T9171 nummod 20,]
R7461 T9118 T9117 punct (,4-Hydroxynonenal
R7462 T9119 T9117 appos 4-HNE,4-Hydroxynonenal
R7463 T9120 T9117 punct ),4-Hydroxynonenal
R7464 T9171 T9167 pobj ],after
R7465 T9121 T9115 punct ",",immunoreactivity
R7466 T9122 T9123 det a,marker
R7467 T9123 T9115 appos marker,immunoreactivity
R7468 T9172 T9159 punct .,induces
R7469 T9124 T9123 prep of,marker
R747 T955 T954 pobj breakdown,including
R7470 T9125 T9126 amod lipid,peroxidation
R7471 T9126 T9124 pobj peroxidation,of
R7472 T9173 T9177 advmod Here,revealed
R7473 T9127 T9113 punct ",",decreases
R7474 T9128 T9113 prep in,decreases
R7475 T9129 T9130 det the,cortex
R7476 T9130 T9128 pobj cortex,in
R7477 T9131 T9130 cc and,cortex
R7478 T9132 T9134 det the,subfield
R7479 T9174 T9177 punct ",",revealed
R748 T956 T955 prep of,breakdown
R7480 T9133 T9134 compound CA3,subfield
R7481 T9134 T9130 conj subfield,cortex
R7482 T9175 T9176 poss our,results
R7483 T9176 T9177 nsubj results,revealed
R7484 T9135 T9134 prep of,subfield
R7485 T9177 T9177 ROOT revealed,revealed
R7486 T9136 T9135 pobj hippocampus,of
R7487 T9137 T9113 prep after,decreases
R7488 T9178 T9192 mark that,was
R7489 T9138 T9139 compound TBI,[
R749 T957 T958 amod blood-brain,barrier
R7490 T9139 T9141 nmod [,]
R7491 T9179 T9192 nsubj overexpression,was
R7492 T9140 T9141 nummod 19,]
R7493 T9141 T9137 pobj ],after
R7494 T9142 T9107 punct .,improves
R7495 T9180 T9179 prep of,overexpression
R7496 T9143 T9150 prep On,appear
R7497 T9144 T9146 det the,hand
R7498 T9181 T9180 pobj TNF-α,of
R7499 T9182 T9181 punct ",",TNF-α
R750 T958 T956 pobj barrier,of
R7500 T9145 T9146 amod other,hand
R7501 T9146 T9143 pobj hand,On
R7502 T9183 T9181 conj IL-1β,TNF-α
R7503 T9147 T9150 punct ",",appear
R7504 T9148 T9149 amod Nrf2-deficient,mice
R7505 T9184 T9183 punct ",",IL-1β
R7506 T9149 T9150 nsubj mice,appear
R7507 T9150 T9150 ROOT appear,appear
R7508 T9185 T9183 conj IL-6,IL-1β
R7509 T9151 T9152 advmod more,susceptible
R751 T959 T960 punct (,BBB
R7510 T9152 T9150 oprd susceptible,appear
R7511 T9153 T9152 prep to,susceptible
R7512 T9186 T9185 punct ",",IL-6
R7513 T9154 T9153 pobj TBI,to
R7514 T9155 T9150 punct .,appear
R7515 T9187 T9185 cc and,IL-6
R7516 T9188 T9185 conj MMP9,IL-6
R7517 T9189 T9179 prep after,overexpression
R7518 T9190 T9191 compound scratch,injury
R7519 T9191 T9189 pobj injury,after
R752 T960 T955 parataxis BBB,breakdown
R7520 T9192 T9194 auxpass was,aggravated
R7521 T9253 T9253 ROOT found,found
R7522 T9193 T9194 advmod more,aggravated
R7523 T9254 T9255 aux to,be
R7524 T9255 T9253 xcomp be,found
R7525 T9256 T9255 acomp able,be
R7526 T9257 T9258 aux to,inhibit
R7527 T9258 T9256 xcomp inhibit,able
R7528 T9194 T9177 ccomp aggravated,revealed
R7529 T9259 T9261 compound IKK/I,phosphorylation
R753 T961 T960 punct ),BBB
R7530 T9260 T9261 compound κB,phosphorylation
R7531 T9261 T9258 dobj phosphorylation,inhibit
R7532 T9195 T9194 prep in,aggravated
R7533 T9262 T9261 cc and,phosphorylation
R7534 T9263 T9267 nummod p65,translocation
R7535 T9196 T9199 amod cultured,astrocytes
R7536 T9264 T9267 amod NF-κB,translocation
R7537 T9265 T9267 nmod subunit,translocation
R7538 T9197 T9199 amod Nrf2,astrocytes
R7539 T9266 T9267 amod nuclear,translocation
R754 T962 T955 punct ",",breakdown
R7540 T9267 T9261 conj translocation,phosphorylation
R7541 T9198 T9199 compound knockout,astrocytes
R7542 T9268 T9253 punct ",",found
R7543 T9269 T9270 advmod consequently,alleviating
R7544 T9270 T9253 advcl alleviating,found
R7545 T9199 T9195 pobj astrocytes,in
R7546 T9271 T9270 dobj NF-κB,alleviating
R7547 T9272 T9271 csubj signaling,NF-κB
R7548 T9273 T9275 nmod [,]
R7549 T9200 T9194 prep than,aggravated
R755 T963 T964 compound brain,edema
R7550 T9274 T9275 nummod 21,]
R7551 T9275 T9272 dobj ],signaling
R7552 T9276 T9253 punct .,found
R7553 T9201 T9200 prep in,than
R7554 T9277 T9288 cc And,attenuated
R7555 T9278 T9279 amod NF-κB,activation
R7556 T9279 T9288 nsubjpass activation,attenuated
R7557 T9202 T9203 compound wildtype,astrocyetes
R7558 T9280 T9279 acl induced,activation
R7559 T9281 T9280 agent by,induced
R756 T964 T955 conj edema,breakdown
R7560 T9282 T9281 pobj lipopolysaccharide,by
R7561 T9203 T9201 pobj astrocyetes,in
R7562 T9204 T9194 prep for,aggravated
R7563 T9205 T9207 det the,time
R7564 T9283 T9284 punct (,LPS
R7565 T9206 T9207 amod first,time
R7566 T9284 T9282 appos LPS,lipopolysaccharide
R7567 T9207 T9204 pobj time,for
R7568 T9285 T9282 punct ),lipopolysaccharide
R7569 T9286 T9288 aux could,attenuated
R757 T965 T964 punct ",",edema
R7570 T9208 T9194 punct ",",aggravated
R7571 T9287 T9288 auxpass be,attenuated
R7572 T9288 T9288 ROOT attenuated,attenuated
R7573 T9289 T9288 agent by,attenuated
R7574 T9290 T9292 amod diverse,activators
R7575 T9291 T9292 amod Nrf2,activators
R7576 T9292 T9289 pobj activators,by
R7577 T9209 T9194 cc and,aggravated
R7578 T9293 T9292 punct ",",activators
R7579 T9294 T9295 amod such,as
R758 T966 T964 conj infiltration,edema
R7580 T9295 T9292 prep as,activators
R7581 T9296 T9295 pobj SFN,as
R7582 T9210 T9215 nsubj overexpression,led
R7583 T9297 T9296 cc and,SFN
R7584 T9298 T9302 nmod curcumin,[
R7585 T9211 T9210 prep of,overexpression
R7586 T9299 T9300 punct (,CUR
R7587 T9300 T9298 appos CUR,curcumin
R7588 T9301 T9302 punct ),[
R7589 T9212 T9214 det these,mediators
R759 T967 T966 prep of,infiltration
R7590 T9213 T9214 amod proinflammatory,mediators
R7591 T9302 T9296 conj [,SFN
R7592 T9214 T9211 pobj mediators,of
R7593 T9303 T9304 nummod 22,]
R7594 T9215 T9194 conj led,aggravated
R7595 T9304 T9296 conj ],SFN
R7596 T9305 T9288 punct .,attenuated
R7597 T9306 T9311 advmod Furthermore,indicate
R7598 T9216 T9215 prep to,led
R7599 T9307 T9311 punct ",",indicate
R760 T968 T970 amod peripheral,cells
R7600 T9308 T9310 poss our,studies
R7601 T9309 T9310 amod previous,studies
R7602 T9217 T9219 amod more,deaths
R7603 T9310 T9311 nsubj studies,indicate
R7604 T9218 T9219 compound astrocytes,deaths
R7605 T9311 T9311 ROOT indicate,indicate
R7606 T9312 T9316 mark that,induces
R7607 T9313 T9316 nsubj depletion,induces
R7608 T9219 T9216 pobj deaths,to
R7609 T9314 T9313 prep of,depletion
R761 T969 T970 compound blood,cells
R7610 T9315 T9314 pobj Nrf2,of
R7611 T9220 T9177 punct .,revealed
R7612 T9316 T9311 ccomp induces,indicate
R7613 T9317 T9316 dobj augmentation,induces
R7614 T9318 T9317 prep of,augmentation
R7615 T9221 T9222 nsubj Data,obtained
R7616 T9319 T9320 amod NF-κB,activity
R7617 T9320 T9318 pobj activity,of
R7618 T9321 T9320 cc and,activity
R7619 T9222 T9222 ROOT obtained,obtained
R762 T970 T967 pobj cells,of
R7620 T9322 T9323 amod inflammatory,response
R7621 T9323 T9320 conj response,activity
R7622 T9324 T9323 prep in,response
R7623 T9223 T9222 prep from,obtained
R7624 T9325 T9324 pobj lung,in
R7625 T9326 T9325 punct ",",lung
R7626 T9327 T9325 conj brain,lung
R7627 T9328 T9327 punct ",",brain
R7628 T9329 T9323 cc and,response
R7629 T9224 T9225 compound animal,studies
R763 T971 T966 punct ",",infiltration
R7630 T9330 T9316 oprd intestine,induces
R7631 T9331 T9316 prep after,induces
R7632 T9332 T9333 compound TBI,[
R7633 T9225 T9223 pobj studies,from
R7634 T9333 T9331 pobj [,after
R7635 T9334 T9333 nummod 4,[
R7636 T9335 T9333 punct ",",[
R7637 T9336 T9333 appos 5,[
R7638 T9226 T9222 conj suggest,obtained
R7639 T9337 T9333 punct ",",[
R764 T972 T966 cc and,infiltration
R7640 T9338 T9339 nummod 23,]
R7641 T9227 T9228 det the,possibility
R7642 T9339 T9333 appos ],[
R7643 T9340 T9311 punct .,indicate
R7644 T9341 T9346 nsubj Results,confirmed
R7645 T9228 T9226 dobj possibility,suggest
R7646 T9342 T9341 prep from,Results
R7647 T9343 T9344 det this,study
R7648 T9229 T9236 mark that,achieved
R7649 T9344 T9342 pobj study,from
R765 T973 T966 conj activation,infiltration
R7650 T9345 T9346 advmod further,confirmed
R7651 T9346 T9346 ROOT confirmed,confirmed
R7652 T9230 T9231 amod antioxidant,effect
R7653 T9347 T9348 amod such,relationship
R7654 T9348 T9349 nsubj relationship,existed
R7655 T9349 T9346 ccomp existed,confirmed
R7656 T9231 T9236 nsubjpass effect,achieved
R7657 T9232 T9231 prep of,effect
R7658 T9233 T9232 pobj Nrf2,of
R7659 T9234 T9236 aux may,achieved
R766 T974 T973 prep of,activation
R7660 T9350 T9349 prep in,existed
R7661 T9235 T9236 auxpass be,achieved
R7662 T9351 T9352 amod cultured,astrocytes
R7663 T9352 T9350 pobj astrocytes,in
R7664 T9236 T9228 acl achieved,possibility
R7665 T9353 T9349 prep after,existed
R7666 T9354 T9355 compound scratch,injury
R7667 T9237 T9236 agent by,achieved
R7668 T9355 T9353 pobj injury,after
R7669 T9356 T9346 punct .,confirmed
R767 T975 T977 amod resident,cells
R7670 T9357 T9358 amod Enhanced,activation
R7671 T9238 T9237 pobj suppression,by
R7672 T9358 T9363 nsubjpass activation,discovered
R7673 T9359 T9358 prep of,activation
R7674 T9360 T9359 pobj NF-κB,of
R7675 T9361 T9363 auxpass is,discovered
R7676 T9362 T9363 advmod also,discovered
R7677 T9363 T9363 ROOT discovered,discovered
R7678 T9364 T9363 prep in,discovered
R7679 T9239 T9238 prep of,suppression
R768 T976 T977 amod immunocompetent,cells
R7680 T9365 T9364 pobj lung,in
R7681 T9366 T9364 punct ",",in
R7682 T9367 T9364 conj macrophages,in
R7683 T9240 T9241 amod proinflammatory,pathways
R7684 T9368 T9367 punct ",",macrophages
R7685 T9369 T9367 cc and,macrophages
R7686 T9370 T9372 amod mouse,fibroblasts
R7687 T9241 T9239 pobj pathways,of
R7688 T9371 T9372 amod embryonic,fibroblasts
R7689 T9372 T9367 conj fibroblasts,macrophages
R769 T977 T974 pobj cells,of
R7690 T9242 T9244 nsubjpass which,mediated
R7691 T9373 T9372 prep of,fibroblasts
R7692 T9374 T9375 amod Nrf2-deficient,mice
R7693 T9375 T9373 pobj mice,of
R7694 T9243 T9244 auxpass are,mediated
R7695 T9376 T9363 prep after,discovered
R7696 T9377 T9378 amod experimental,sepsis
R7697 T9244 T9241 relcl mediated,pathways
R7698 T9378 T9376 pobj sepsis,after
R7699 T9379 T9381 nmod [,]
R770 T978 T966 punct ",",infiltration
R7700 T9245 T9244 agent by,mediated
R7701 T9380 T9381 nummod 24,]
R7702 T9246 T9247 amod NF-κB,signaling
R7703 T9247 T9245 pcomp signaling,by
R7704 T9381 T9381 ROOT ],]
R7705 T9382 T9363 punct .,discovered
R7706 T9248 T9222 punct .,obtained
R7707 T9383 T9387 advmod Interestingly,reported
R7708 T9384 T9387 punct ",",reported
R7709 T9385 T9387 nsubjpass it,reported
R771 T979 T981 advmod as,as
R7710 T9249 T9253 nsubjpass Administration,found
R7711 T9386 T9387 auxpass is,reported
R7712 T9387 T9387 ROOT reported,reported
R7713 T9388 T9391 mark that,inhibit
R7714 T9250 T9249 prep of,Administration
R7715 T9389 T9391 nsubj NF-κB,inhibit
R7716 T9251 T9250 pobj SFN,of
R7717 T9390 T9391 aux can,inhibit
R7718 T9391 T9387 ccomp inhibit,reported
R7719 T9392 T9391 dobj Nrf2,inhibit
R772 T980 T981 advmod well,as
R7720 T9252 T9253 auxpass is,found
R7721 T9393 T9391 prep at,inhibit
R7722 T9394 T9395 amod transcriptional,level
R7723 T9411 T9413 det the,domain
R7724 T9395 T9393 pobj level,at
R7725 T9396 T9387 punct .,reported
R7726 T9397 T9399 nmod NF-κB,subunit
R7727 T9398 T9397 nummod p65,NF-κB
R7728 T9399 T9400 nsubj subunit,repressed
R7729 T9400 T9400 ROOT repressed,repressed
R773 T981 T955 cc as,breakdown
R7730 T9401 T9403 det the,pathway
R7731 T9412 T9413 compound CH1-KIX,domain
R7732 T9402 T9403 amod Nrf2-ARE,pathway
R7733 T9403 T9400 dobj pathway,repressed
R7734 T9404 T9400 prep at,repressed
R7735 T9413 T9410 pobj domain,with
R7736 T9405 T9406 amod transcriptional,level
R7737 T9406 T9404 pobj level,at
R7738 T9407 T9400 prep by,repressed
R7739 T9408 T9409 amod competitive,interaction
R774 T982 T983 det the,release
R7740 T9414 T9413 prep of,domain
R7741 T9409 T9407 pobj interaction,by
R7742 T9410 T9409 prep with,interaction
R7743 T9415 T9414 pobj CBP,of
R7744 T9416 T9415 cc or,CBP
R7745 T9417 T9419 amod local,hypoacetylation
R7746 T9449 T9446 punct ),kinase
R7747 T9418 T9419 compound histone,hypoacetylation
R7748 T9450 T9427 conj pathway,indicate
R7749 T9419 T9420 compound hypoacetylation,[
R775 T983 T947 conj release,initiation
R7750 T9420 T9415 conj [,CBP
R7751 T9451 T9453 nmod [,]
R7752 T9452 T9453 nummod 26,]
R7753 T9421 T9422 nummod 25,]
R7754 T9453 T9450 dobj ],pathway
R7755 T9454 T9427 punct .,indicate
R7756 T9422 T9420 appos ],[
R7757 T9455 T9458 nsubjpass It,confirmed
R7758 T9456 T9458 aux has,confirmed
R7759 T9423 T9400 punct .,repressed
R776 T984 T983 prep of,release
R7760 T9457 T9458 auxpass been,confirmed
R7761 T9458 T9458 ROOT confirmed,confirmed
R7762 T9459 T9463 mark that,detected
R7763 T9424 T9426 predet All,findings
R7764 T9460 T9463 nsubjpass Nrf2,detected
R7765 T9425 T9426 det these,findings
R7766 T9426 T9427 nsubj findings,indicate
R7767 T9461 T9463 auxpass is,detected
R7768 T9462 T9463 advmod mainly,detected
R7769 T9427 T9427 ROOT indicate,indicate
R777 T985 T987 amod numerous,mediators
R7770 T9463 T9458 ccomp detected,confirmed
R7771 T9464 T9463 prep in,detected
R7772 T9428 T9431 det the,crosstalk
R7773 T9465 T9464 pobj nucleus,in
R7774 T9466 T9465 prep of,nucleus
R7775 T9467 T9466 pobj astrocytes,of
R7776 T9468 T9463 prep after,detected
R7777 T9469 T9470 compound TBI,[
R7778 T9429 T9431 amod potential,crosstalk
R7779 T9470 T9468 pobj [,after
R778 T986 T987 amod immune,mediators
R7780 T9471 T9472 nummod 18,]
R7781 T9472 T9470 appos ],[
R7782 T9430 T9431 compound complicate,crosstalk
R7783 T9473 T9458 punct .,confirmed
R7784 T9474 T9496 prep In,reasoned
R7785 T9475 T9474 pobj view,In
R7786 T9431 T9427 dobj crosstalk,indicate
R7787 T9476 T9475 prep of,view
R7788 T9477 T9478 det the,fact
R7789 T9432 T9431 prep between,crosstalk
R779 T987 T984 pobj mediators,of
R7790 T9478 T9476 pobj fact,of
R7791 T9479 T9481 mark that,is
R7792 T9480 T9481 nsubj Nrf2,is
R7793 T9433 T9432 pobj NF-κB,between
R7794 T9481 T9478 acl is,fact
R7795 T9482 T9484 det a,factor
R7796 T9483 T9484 compound transcription,factor
R7797 T9434 T9433 cc and,NF-κB
R7798 T9484 T9481 attr factor,is
R7799 T9485 T9487 nsubj which,take
R780 T988 T989 amod such,as
R7800 T9435 T9433 conj Nrf2,NF-κB
R7801 T9486 T9487 aux should,take
R7802 T9487 T9484 relcl take,factor
R7803 T9488 T9487 dobj function,take
R7804 T9436 T9433 punct ",",NF-κB
R7805 T9489 T9490 advmod mainly,in
R7806 T9490 T9487 prep in,take
R7807 T9437 T9440 nsubjpass which,regulated
R7808 T9491 T9490 pobj nucleus,in
R7809 T9492 T9496 punct ",",reasoned
R781 T989 T987 prep as,mediators
R7810 T9493 T9496 nsubjpass it,reasoned
R7811 T9438 T9440 aux may,regulated
R7812 T9494 T9496 aux can,reasoned
R7813 T9495 T9496 auxpass be,reasoned
R7814 T9496 T9496 ROOT reasoned,reasoned
R7815 T9439 T9440 auxpass be,regulated
R7816 T9497 T9500 mark that,be
R7817 T9498 T9500 nsubj astrocytes,be
R7818 T9499 T9500 aux may,be
R7819 T9440 T9431 relcl regulated,crosstalk
R782 T990 T989 pobj interleukins,as
R7820 T9500 T9496 ccomp be,reasoned
R7821 T9501 T9502 nummod one,kind
R7822 T9441 T9440 agent by,regulated
R7823 T9502 T9500 attr kind,be
R7824 T9503 T9502 prep of,kind
R7825 T9504 T9505 compound respondent,cells
R7826 T9505 T9503 pobj cells,of
R7827 T9506 T9502 prep in,kind
R7828 T9507 T9506 pobj activation,in
R7829 T9442 T9446 det the,kinase
R783 T991 T990 cc and,interleukins
R7830 T9508 T9507 prep of,activation
R7831 T9509 T9510 compound Nrf2-ARE,pathway
R7832 T9510 T9508 pobj pathway,of
R7833 T9511 T9500 prep after,be
R7834 T9443 T9446 amod upstream,kinase
R7835 T9512 T9511 pobj TBI,after
R7836 T9513 T9496 punct .,reasoned
R7837 T9444 T9445 amod mitogen-activated,protein
R7838 T9514 T9515 amod Previous,study
R7839 T9515 T9516 nsubj study,identified
R784 T992 T993 amod chemotactic,factors
R7840 T9445 T9446 compound protein,kinase
R7841 T9516 T9516 ROOT identified,identified
R7842 T9517 T9518 det the,expression
R7843 T9518 T9516 dobj expression,identified
R7844 T9446 T9441 pobj kinase,by
R7845 T9519 T9518 prep of,expression
R7846 T9520 T9519 pobj TNF-α,of
R7847 T9447 T9448 punct (,MAPKs
R7848 T9521 T9520 punct ",",TNF-α
R7849 T9522 T9520 conj IL-1β,TNF-α
R785 T993 T990 conj factors,interleukins
R7850 T9523 T9522 punct ",",IL-1β
R7851 T9448 T9446 appos MAPKs,kinase
R7852 T9524 T9522 cc and,IL-1β
R7853 T9525 T9522 conj IL-6,IL-1β
R7854 T9526 T9516 prep in,identified
R7855 T9546 T9549 amod middle,occlusion
R7856 T9527 T9528 amod cultured,astrocytes
R7857 T9528 T9526 pobj astrocytes,in
R7858 T9529 T9516 prep after,identified
R7859 T9547 T9549 amod cerebral,occlusion
R786 T994 T945 conj [,involves
R7860 T9548 T9549 compound artery,occlusion
R7861 T9549 T9545 pobj occlusion,after
R7862 T9530 T9529 pobj treatment,after
R7863 T9531 T9530 prep with,treatment
R7864 T9550 T9554 punct ",",observed
R7865 T9532 T9531 pobj LPS,with
R7866 T9533 T9530 cc or,treatment
R7867 T9551 T9552 amod MMP9-positive,astrocytes
R7868 T9534 T9535 compound oxyhemoglobin,[
R7869 T9535 T9516 dobj [,identified
R787 T995 T996 nummod 1,]
R7870 T9536 T9535 nummod 27,[
R7871 T9552 T9554 nsubjpass astrocytes,observed
R7872 T9537 T9535 punct ",",[
R7873 T9538 T9539 nummod 28,]
R7874 T9553 T9554 auxpass were,observed
R7875 T9554 T9543 ccomp observed,revealed
R7876 T9539 T9535 appos ],[
R7877 T9540 T9516 punct .,identified
R7878 T9541 T9542 det Another,study
R7879 T9542 T9543 nsubj study,revealed
R788 T996 T994 dobj ],[
R7880 T9543 T9543 ROOT revealed,revealed
R7881 T9555 T9554 prep in,observed
R7882 T9544 T9554 mark that,observed
R7883 T9545 T9554 prep after,observed
R7884 T9556 T9557 compound brain,tissues
R7885 T9557 T9555 pobj tissues,in
R7886 T9558 T9554 agent by,observed
R7887 T9559 T9560 compound immunohistochemistry,[
R7888 T9560 T9558 pobj [,by
R7889 T9561 T9562 nummod 29,]
R789 T997 T945 punct .,involves
R7890 T9643 T9642 pobj TNF-α,of
R7891 T9562 T9560 appos ],[
R7892 T9644 T9643 punct ",",TNF-α
R7893 T9645 T9643 conj IL-1β,TNF-α
R7894 T9563 T9543 punct .,revealed
R7895 T9646 T9645 punct ",",IL-1β
R7896 T9647 T9645 conj IL-6,IL-1β
R7897 T9648 T9647 punct ",",IL-6
R7898 T9564 T9565 det Those,results
R7899 T9565 T9566 nsubj results,indicate
R790 T998 T1002 cc And,leads
R7900 T9566 T9566 ROOT indicate,indicate
R7901 T9649 T9647 cc and,IL-6
R7902 T9567 T9568 det the,role
R7903 T9650 T9647 conj MMP9,IL-6
R7904 T9651 T9634 advcl resulting,induced
R7905 T9568 T9566 dobj role,indicate
R7906 T9652 T9651 prep in,resulting
R7907 T9653 T9655 amod more,deaths
R7908 T9569 T9568 prep of,role
R7909 T9654 T9655 compound cell,deaths
R791 T999 T1001 det the,inflammation
R7910 T9655 T9652 pobj deaths,in
R7911 T9656 T9655 prep in,deaths
R7912 T9570 T9569 pobj astrocytes,of
R7913 T9657 T9656 pobj astrocytes,in
R7914 T9658 T9651 prep after,resulting
R7915 T9571 T9570 prep in,astrocytes
R7916 T9659 T9660 compound scratch,injury
R7917 T9660 T9658 pobj injury,after
R7918 T9661 T9634 punct .,induced
R7919 T9572 T9573 amod inflammatory,process
R792 T1000 T1001 amod subsequent,inflammation
R7920 T9662 T9663 det These,results
R7921 T9663 T9664 nsubj results,suggest
R7922 T9573 T9571 pobj process,in
R7923 T9664 T9664 ROOT suggest,suggest
R7924 T9665 T9668 mark that,be
R7925 T9574 T9568 prep after,role
R7926 T9666 T9668 nsubj Nrf2,be
R7927 T9667 T9668 aux may,be
R7928 T9668 T9664 ccomp be,suggest
R7929 T9669 T9671 det an,target
R793 T1001 T1002 nsubj inflammation,leads
R7930 T9670 T9671 amod important,target
R7931 T9671 T9668 attr target,be
R7932 T9575 T9576 compound brain,injury
R7933 T9672 T9671 prep for,target
R7934 T9673 T9674 amod anti-inflammatory,therapy
R7935 T9674 T9672 pobj therapy,for
R7936 T9576 T9574 pobj injury,after
R7937 T9675 T9668 prep after,be
R7938 T9676 T9675 pobj TBI,after
R7939 T9577 T9566 punct .,indicate
R794 T1002 T1002 ROOT leads,leads
R7940 T9677 T9664 punct .,suggest
R7941 T9578 T9583 cc But,is
R7942 T9579 T9583 prep till,is
R7943 T9580 T9579 pcomp now,till
R7944 T9581 T9583 punct ",",is
R7945 T9582 T9583 expl there,is
R7946 T9583 T9583 ROOT is,is
R7947 T9584 T9585 det no,study
R7948 T9585 T9583 attr study,is
R7949 T9586 T9585 acl focused,study
R795 T1003 T1002 prep to,leads
R7950 T9587 T9586 prep on,focused
R7951 T9588 T9589 det the,relationship
R7952 T9589 T9587 pobj relationship,on
R7953 T9590 T9589 prep among,relationship
R7954 T9591 T9590 pobj astrocytes,among
R7955 T9592 T9589 punct ",",relationship
R7956 T9593 T9589 appos Nrf2,relationship
R7957 T9594 T9593 punct ",",Nrf2
R7958 T9595 T9589 cc and,relationship
R7959 T9596 T9597 amod proinflammatory,mediators
R796 T1004 T1005 amod secondary,damage
R7960 T9597 T9589 conj mediators,relationship
R7961 T9598 T9586 prep after,focused
R7964 T9599 T9598 pobj TBI,after
R7967 T9600 T9583 punct .,is
R797 T1005 T1003 pobj damage,to
R7974 T9601 T9602 poss Our,results
R798 T1006 T1008 preconj not,in
R7985 T9602 T9603 nsubj results,demonstrated
R7989 T9603 T9603 ROOT demonstrated,demonstrated
R799 T1007 T1006 advmod only,not
R7991 T9604 T9606 det the,expression
R7994 T9605 T9606 amod upregulated,expression
R7995 T9606 T9603 dobj expression,demonstrated
R7996 T9607 T9606 prep of,expression
R7998 T9608 T9607 pobj TNF-α,of
R800 T1008 T1005 prep in,damage
R8000 T9609 T9608 punct ",",TNF-α
R8003 T9610 T9608 conj IL-1β,TNF-α
R8004 T9611 T9610 punct ",",IL-1β
R8005 T9612 T9610 conj IL-6,IL-1β
R8006 T9613 T9612 punct ",",IL-6
R8007 T9614 T9612 cc and,IL-6
R8009 T9615 T9612 conj MMP9,IL-6
R801 T1009 T1008 pobj brain,in
R8014 T9616 T9615 prep in,MMP9
R8017 T9617 T9618 compound Nrf2,knockout
R802 T1010 T1008 cc but,in
R8020 T9618 T9616 pobj knockout,in
R8024 T9619 T9606 appos astrocytes,expression
R803 T1011 T1010 advmod also,but
R8031 T9620 T9603 prep after,demonstrated
R8034 T9621 T9622 compound scratch,injury
R8036 T9622 T9620 pobj injury,after
R8038 T9623 T9622 prep for,injury
R8039 T9624 T9626 det the,time
R804 T1012 T1008 conj in,in
R8043 T9625 T9626 amod first,time
R8047 T9626 T9623 pobj time,for
R805 T1013 T1014 amod other,organs
R8051 T9627 T9603 punct .,demonstrated
R8054 T9628 T9634 prep In,induced
R8055 T9629 T9628 pobj conclusion,In
R8057 T9630 T9634 punct ",",induced
R8058 T9631 T9634 nsubj depletion,induced
R806 T1014 T1012 pobj organs,in
R8062 T9632 T9631 prep of,depletion
R8063 T9633 T9632 pobj Nrf2,of
R8064 T9634 T9634 ROOT induced,induced
R8065 T9635 T9636 det the,activation
R8067 T9636 T9634 dobj activation,induced
R8069 T9637 T9636 prep of,activation
R807 T1015 T1008 pobj [,in
R8072 T9638 T9637 pobj NF-κB,of
R8073 T9639 T9636 cc and,activation
R8074 T9640 T9641 det the,expression
R8075 T9641 T9636 conj expression,activation
R808 T1016 T1015 nummod 2,[
R8082 T9642 T9641 prep of,expression
R809 T1017 T1018 nummod 4,]
R810 T1018 T1015 appos ],[
R811 T1019 T1002 punct .,leads
R812 T1020 T1021 compound Nuclear,factor
R813 T1021 T1022 nsubj factor,erythroid
R814 T1022 T1028 nsubj erythroid,is
R815 T1023 T1022 advmod 2-related,erythroid
R816 T1024 T1023 nummod factor2,2-related
R817 T1025 T1026 punct (,Nrf2
R818 T1026 T1023 appos Nrf2,2-related
R819 T1027 T1022 punct ),erythroid
R820 T1028 T1028 ROOT is,is
R821 T1029 T1031 det a,factor
R822 T1030 T1031 compound transcription,factor
R823 T1031 T1028 attr factor,is
R824 T1032 T1033 nsubj that,regulates
R825 T1033 T1031 relcl regulates,factor
R826 T1034 T1035 amod many,kinds
R827 T1035 T1033 dobj kinds,regulates
R828 T1036 T1035 prep of,kinds
R829 T1037 T1038 amod antioxidant,genes
R830 T1038 T1036 pobj genes,of
R831 T1039 T1028 punct .,is
R832 T1040 T1041 amod Several,studies
R833 T1041 T1043 nsubj studies,demonstrated
R834 T1042 T1043 aux have,demonstrated
R835 T1043 T1043 ROOT demonstrated,demonstrated
R836 T1044 T1046 mark that,regulates
R837 T1045 T1046 nsubj Nrf2,regulates
R838 T1046 T1043 ccomp regulates,demonstrated
R839 T1047 T1048 det the,inflammation
R840 T1048 T1046 dobj inflammation,regulates
R841 T1049 T1048 prep in,inflammation
R842 T1050 T1051 det the,brain
R843 T1051 T1049 pobj brain,in
R844 T1052 T1046 prep after,regulates
R845 T1053 T1055 amod traumatic,injury
R846 T1054 T1055 compound brain,injury
R847 T1055 T1052 pobj injury,after
R848 T1056 T1055 punct (,injury
R849 T1057 T1055 appos TBI,injury
R850 T1058 T1055 punct ),injury
R851 T1059 T1043 punct .,demonstrated
R852 T1060 T1063 nsubjpass It,showed
R853 T1061 T1063 auxpass was,showed
R854 T1062 T1063 advmod also,showed
R855 T1063 T1063 ROOT showed,showed
R856 T1064 T1067 mark that,induce
R857 T1065 T1067 nsubj TBI,induce
R858 T1066 T1067 aux could,induce
R859 T1067 T1063 ccomp induce,showed
R860 T1068 T1069 advmod more,aggravated
R861 T1069 T1070 amod aggravated,damage
R862 T1070 T1067 dobj damage,induce
R863 T1071 T1070 prep in,damage
R864 T1072 T1074 amod Nrf2,mice
R865 T1073 T1074 compound knockout,mice
R866 T1074 T1071 pobj mice,in
R867 T1075 T1070 prep than,damage
R868 T1076 T1075 prep in,than
R869 T1077 T1078 compound wildtype,mice
R870 T1078 T1076 pobj mice,in
R871 T1079 T1075 pobj [,than
R872 T1080 T1081 nummod 5,]
R873 T1081 T1079 nsubj ],[
R874 T1082 T1063 punct .,showed
R875 T1083 T1091 prep On,extenuated
R876 T1084 T1085 det the,contrary
R877 T1085 T1083 pobj contrary,On
R878 T1086 T1091 punct ",",extenuated
R879 T1087 T1088 amod such,inflammation
R880 T1088 T1091 nsubjpass inflammation,extenuated
R881 T1089 T1091 aux can,extenuated
R882 T1090 T1091 auxpass be,extenuated
R883 T1091 T1091 ROOT extenuated,extenuated
R884 T1092 T1091 prep through,extenuated
R885 T1093 T1092 pcomp elevating,through
R886 T1094 T1095 det the,level
R887 T1095 T1093 dobj level,elevating
R888 T1096 T1095 prep of,level
R889 T1097 T1096 pobj Nrf2,of
R890 T1098 T1093 prep by,elevating
R891 T1099 T1100 poss its,inducers
R892 T1100 T1098 pobj inducers,by
R893 T1101 T1100 punct ",",inducers
R894 T1102 T1103 amod such,as
R895 T1103 T1100 prep as,inducers
R896 T1104 T1103 pobj sulforaphane,as
R897 T1105 T1106 punct (,SFN
R898 T1106 T1108 nmod SFN,[
R899 T1107 T1106 punct ),SFN
R900 T1108 T1110 nmod [,]
R901 T1109 T1110 nummod 6,]
R902 T1110 T1100 appos ],inducers
R903 T1111 T1091 punct .,extenuated
R904 T1112 T1113 nsubj It,is
R905 T1113 T1113 ROOT is,is
R906 T1114 T1115 advmod well,documented
R907 T1115 T1113 acomp documented,is
R908 T1116 T1118 mark that,play
R909 T1117 T1118 nsubj astrocytes,play
R910 T1118 T1115 ccomp play,documented
R911 T1119 T1121 det a,role
R912 T1120 T1121 amod critical,role
R913 T1121 T1118 dobj role,play
R914 T1122 T1121 prep in,role
R915 T1123 T1122 pcomp maintaining,in
R916 T1124 T1126 amod normal,physiology
R917 T1125 T1126 compound brain,physiology
R918 T1126 T1123 dobj physiology,maintaining
R919 T1127 T1123 cc and,maintaining
R920 T1128 T1123 conj responding,maintaining
R921 T1129 T1128 prep to,responding
R922 T1130 T1129 pobj injury,to
R923 T1131 T1130 cc or,injury
R924 T1132 T1130 conj disease,injury
R925 T1133 T1113 punct .,is
R926 T1134 T1142 prep In,performed
R927 T1135 T1134 pobj fact,In
R928 T1136 T1142 punct ",",performed
R929 T1137 T1140 det all,studies
R930 T1138 T1140 det the,studies
R931 T1139 T1140 amod aforementioned,studies
R932 T1140 T1142 nsubjpass studies,performed
R933 T1141 T1142 auxpass are,performed
R934 T1142 T1142 ROOT performed,performed
R935 T1143 T1142 prep in,performed
R936 T1144 T1143 pobj vivo,in
R937 T1145 T1142 punct .,performed
R938 T1146 T1148 nsubjpass Little,known
R939 T1147 T1148 auxpass is,known
R940 T1148 T1148 ROOT known,known
R941 T1149 T1148 prep about,known
R942 T1150 T1151 det the,relationship
R943 T1151 T1149 pobj relationship,about
R944 T1152 T1151 prep between,relationship
R945 T1153 T1152 pobj Nrf2,between
R946 T1154 T1153 cc and,Nrf2
R947 T1155 T1153 conj inflammation,Nrf2
R948 T1156 T1155 prep in,inflammation
R949 T1157 T1156 pobj astrocytes,in
R950 T1158 T1151 prep after,relationship
R951 T1159 T1158 pobj TBI,after
R952 T1160 T1148 punct .,known
R953 T1161 T1165 advmod Therefore,analysed
R954 T1162 T1165 punct ",",analysed
R955 T1163 T1165 advmod here,analysed
R956 T1164 T1165 nsubj we,analysed
R957 T1165 T1165 ROOT analysed,analysed
R958 T1166 T1167 det the,influence
R959 T1167 T1165 dobj influence,analysed
R960 T1168 T1167 prep of,influence
R961 T1169 T1168 pobj Nrf2,of
R962 T1170 T1167 prep on,influence
R963 T1171 T1172 det the,expression
R964 T1172 T1170 pobj expression,on
R965 T1173 T1172 prep of,expression
R966 T1174 T1175 amod proinflammatory,cytokines
R967 T1175 T1173 pobj cytokines,of
R968 T1176 T1175 prep in,cytokines
R969 T1177 T1179 amod primary,astrocytes
R970 T1178 T1179 amod cultured,astrocytes
R971 T1179 T1176 pobj astrocytes,in
R972 T1180 T1179 prep from,astrocytes
R973 T1181 T1182 amod transgenic,mice
R974 T1182 T1180 pobj mice,from
R975 T1183 T1165 prep after,analysed
R976 T1184 T1185 compound scratch,injury
R977 T1185 T1183 pobj injury,after
R978 T1186 T1165 punct .,analysed