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PMC:3312845 / 28471-34035 JSONTXT 25 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T12893 11-14 DT denotes The
T12894 15-20 JJ denotes major
T12895 21-29 NNS denotes findings
T12896 30-32 IN denotes in
T12897 33-36 DT denotes the
T12898 37-44 JJ denotes present
T12899 45-50 NN denotes study
T12900 51-54 VBP denotes are
T12901 55-59 IN denotes that
T12902 60-65 JJ denotes TNF-α
T12903 66-75 VBG denotes signaling
T12904 76-82 VBD denotes showed
T12905 83-91 JJ denotes cellular
T12906 92-100 JJ denotes specific
T12907 101-110 NNS denotes responses
T12908 111-113 IN denotes of
T12909 114-119 JJ denotes NF-κB
T12910 120-135 NN denotes phosphorylation
T12911 136-138 IN denotes in
T12912 139-142 DT denotes the
T12913 143-145 NN denotes PC
T12914 146-155 VBG denotes following
T12915 156-158 NNP denotes SE
T12916 158-159 , denotes ,
T12917 160-165 WDT denotes which
T12918 166-169 MD denotes may
T12919 170-172 VB denotes be
T12920 173-180 VBN denotes related
T12921 181-183 TO denotes to
T12922 184-193 JJ denotes vasogenic
T12923 194-199 NN denotes edema
T12924 200-209 NN denotes formation
T12925 210-218 VBN denotes followed
T12926 219-221 IN denotes by
T12927 222-232 NN denotes neutrophil
T12928 233-245 NN denotes infiltration
T12929 245-246 . denotes .
T12930 247-250 NNP denotes BBB
T12931 251-261 NN denotes disruption
T12932 262-265 VBZ denotes has
T12933 266-270 VBN denotes been
T12934 271-279 VBN denotes reported
T12935 280-282 IN denotes in
T12936 283-295 JJ denotes experimental
T12937 296-299 CC denotes and
T12938 300-305 JJ denotes human
T12939 306-314 NN denotes epilepsy
T12940 315-316 NNP denotes [
T12941 316-330 CD denotes 12,13,15,16,28
T12942 330-331 NNP denotes ]
T12943 331-332 . denotes .
T12944 333-340 NNP denotes Leakage
T12945 341-343 IN denotes of
T12946 344-357 JJ denotes serum-derived
T12947 358-368 NNS denotes components
T12948 369-373 IN denotes into
T12949 374-377 DT denotes the
T12950 378-391 JJ denotes extracellular
T12951 392-397 NN denotes space
T12952 398-400 VBZ denotes is
T12953 401-411 VBN denotes associated
T12954 412-416 IN denotes with
T12955 417-434 NN denotes hyperexcitability
T12956 435-438 CC denotes and
T12957 439-446 NN denotes seizure
T12958 447-452 NN denotes onset
T12959 453-454 NNP denotes [
T12960 454-468 CD denotes 12,13,15,16,28
T12961 468-469 NNP denotes ]
T12962 469-470 . denotes .
T12963 471-482 RB denotes Furthermore
T12964 482-483 , denotes ,
T12965 484-495 NN denotes dysfunction
T12966 496-498 IN denotes of
T12967 499-502 DT denotes the
T12968 503-506 NNP denotes BBB
T12969 507-512 VBZ denotes leads
T12970 513-515 TO denotes to
T12971 516-531 NN denotes epileptogenesis
T12972 532-535 CC denotes and
T12973 536-547 VBZ denotes contributes
T12974 548-550 TO denotes to
T12975 551-562 NN denotes progression
T12976 563-565 IN denotes of
T12977 566-574 NN denotes epilepsy
T12978 575-576 NNP denotes [
T12979 576-590 CD denotes 12,13,15,16,28
T12980 590-591 NNP denotes ]
T12981 591-592 . denotes .
T12982 593-595 IN denotes In
T12983 596-599 DT denotes the
T12984 600-607 JJ denotes present
T12985 608-613 NN denotes study
T12986 613-614 , denotes ,
T12987 615-620 JJ denotes TNF-α
T12988 621-637 NN denotes immunoreactivity
T12989 638-641 VBD denotes was
T12990 642-651 RB denotes obviously
T12991 652-660 VBN denotes observed
T12992 661-663 IN denotes in
T12993 664-673 NN denotes microglia
T12994 674-676 IN denotes in
T12995 677-680 DT denotes the
T12996 681-683 NN denotes PC
T12997 684-693 VBG denotes following
T12998 694-696 NNP denotes SE
T12999 696-697 . denotes .
T13000 698-701 NN denotes TNF
T13001 702-710 NN denotes receptor
T13002 711-722 NNS denotes expressions
T13003 723-727 VBD denotes were
T13004 728-732 RB denotes also
T13005 733-745 JJ denotes up-regulated
T13006 746-748 IN denotes in
T13007 749-759 NNS denotes astrocytes
T13008 760-761 -LRB- denotes (
T13009 761-768 CD denotes TNFp55R
T13010 769-772 CC denotes and
T13011 773-780 NNP denotes TNFp75R
T13012 780-781 -RRB- denotes )
T13013 782-785 CC denotes and
T13014 786-797 JJ denotes endothelial
T13015 798-803 NNS denotes cells
T13016 804-805 -LRB- denotes (
T13017 805-812 CD denotes TNFp75R
T13018 812-813 -RRB- denotes )
T13019 813-814 . denotes .
T13020 815-826 RB denotes Furthermore
T13021 826-827 , denotes ,
T13022 828-836 NN denotes blockade
T13023 837-839 IN denotes of
T13024 840-845 JJ denotes TNF-α
T13025 846-855 VBG denotes signaling
T13026 856-858 IN denotes by
T13027 859-866 NNS denotes sTNFp55
T13028 867-875 NN denotes infusion
T13029 876-887 RB denotes effectively
T13030 888-889 -LRB- denotes (
T13031 889-892 CC denotes but
T13032 893-896 RB denotes not
T13033 897-907 RB denotes completely
T13034 907-908 -RRB- denotes )
T13035 909-916 VBN denotes reduced
T13036 917-924 NNS denotes volumes
T13037 925-927 IN denotes of
T13038 928-938 JJ denotes SE-induced
T13039 939-948 JJ denotes vasogenic
T13040 949-954 NN denotes edema
T13041 955-958 CC denotes and
T13042 959-967 JJ denotes neuronal
T13043 968-974 NN denotes damage
T13044 975-977 IN denotes in
T13045 978-981 DT denotes the
T13046 982-984 NN denotes PC
T13047 984-985 . denotes .
T13048 986-991 DT denotes These
T13049 992-1000 NNS denotes findings
T13050 1001-1009 VBP denotes indicate
T13051 1010-1014 IN denotes that
T13052 1015-1020 NNP denotes TNF-α
T13053 1021-1024 MD denotes may
T13054 1025-1036 VB denotes participate
T13055 1037-1039 IN denotes in
T13056 1040-1050 JJ denotes astroglial
T13057 1051-1054 CC denotes and
T13058 1055-1066 JJ denotes endothelial
T13059 1067-1076 NNS denotes responses
T13060 1077-1079 TO denotes to
T13061 1080-1082 NNP denotes SE
T13062 1082-1083 , denotes ,
T13063 1084-1089 WDT denotes which
T13064 1090-1093 VBP denotes are
T13065 1094-1102 JJ denotes relevant
T13066 1103-1105 TO denotes to
T13067 1106-1116 JJ denotes SE-induced
T13068 1117-1126 JJ denotes vasogenic
T13069 1127-1132 NN denotes edema
T13070 1133-1142 NN denotes formation
T13071 1143-1144 NNP denotes [
T13072 1144-1147 CD denotes 5-8
T13073 1147-1148 NNP denotes ]
T13074 1148-1149 . denotes .
T13075 1150-1156 RB denotes Indeed
T13076 1156-1157 , denotes ,
T13077 1158-1163 JJ denotes TNF-α
T13078 1164-1173 VBG denotes signaling
T13079 1174-1183 NNS denotes increases
T13080 1184-1187 NNP denotes BBB
T13081 1188-1200 NN denotes permeability
T13082 1201-1203 IN denotes in
T13083 1204-1211 JJ denotes various
T13084 1212-1224 JJ denotes experimental
T13085 1225-1232 NN denotes disease
T13086 1233-1239 NNS denotes models
T13087 1240-1241 NNP denotes [
T13088 1241-1243 CD denotes 29
T13089 1243-1244 NNP denotes ]
T13090 1244-1245 . denotes .
T13091 1246-1248 IN denotes In
T13092 1249-1252 DT denotes the
T13093 1253-1260 JJ denotes present
T13094 1261-1266 NN denotes study
T13095 1266-1267 , denotes ,
T13096 1268-1275 JJ denotes sTNFp55
T13097 1276-1284 NN denotes infusion
T13098 1285-1290 MD denotes could
T13099 1291-1294 RB denotes not
T13100 1295-1305 RB denotes completely
T13101 1306-1313 VB denotes prevent
T13102 1314-1324 JJ denotes SE-induced
T13103 1325-1334 JJ denotes vasogenic
T13104 1335-1340 NN denotes edema
T13105 1341-1344 CC denotes and
T13106 1345-1353 JJ denotes neuronal
T13107 1354-1360 NN denotes damage
T13108 1361-1363 IN denotes in
T13109 1364-1367 DT denotes the
T13110 1368-1370 NN denotes PC
T13111 1370-1371 . denotes .
T13112 1372-1381 RB denotes Therefore
T13113 1381-1382 , denotes ,
T13114 1383-1386 PRP$ denotes our
T13115 1387-1395 NNS denotes findings
T13116 1396-1403 VBP denotes suggest
T13117 1404-1408 IN denotes that
T13118 1409-1414 JJ denotes TNF-α
T13119 1415-1424 VBG denotes signaling
T13120 1425-1428 MD denotes may
T13121 1429-1432 RB denotes not
T13122 1433-1435 VB denotes be
T13123 1436-1437 DT denotes a
T13124 1438-1444 JJ denotes unique
T13125 1445-1453 JJ denotes upstream
T13126 1454-1459 NN denotes event
T13127 1460-1462 IN denotes in
T13128 1463-1472 JJ denotes vasogenic
T13129 1473-1478 NN denotes edema
T13130 1479-1490 NN denotes development
T13131 1490-1491 . denotes .
T13132 1492-1495 NNS denotes p65
T13133 1496-1511 NN denotes phosphorylation
T13134 1512-1514 IN denotes of
T13135 1515-1520 JJ denotes NF-κB
T13136 1521-1529 VBZ denotes enhances
T13137 1530-1533 PRP$ denotes its
T13138 1534-1549 NN denotes transactivation
T13139 1550-1559 NN denotes potential
T13140 1559-1560 , denotes ,
T13141 1561-1564 CC denotes and
T13142 1565-1568 CD denotes p65
T13143 1569-1584 NN denotes phosphorylation
T13144 1585-1591 VBZ denotes occurs
T13145 1592-1594 IN denotes in
T13146 1595-1601 CC denotes either
T13147 1602-1605 DT denotes the
T13148 1606-1615 NN denotes cytoplasm
T13149 1616-1618 CC denotes or
T13150 1619-1622 DT denotes the
T13151 1623-1630 NN denotes nucleus
T13152 1631-1632 NNP denotes [
T13153 1632-1634 CD denotes 30
T13154 1634-1635 NNP denotes ]
T13155 1635-1636 . denotes .
T13156 1637-1639 IN denotes In
T13157 1640-1643 DT denotes the
T13158 1644-1651 JJ denotes present
T13159 1652-1657 NN denotes study
T13160 1657-1658 , denotes ,
T13161 1659-1669 NN denotes p65-Thr435
T13162 1670-1686 NN denotes immunoreactivity
T13163 1687-1690 VBD denotes was
T13164 1691-1699 VBN denotes detected
T13165 1700-1702 IN denotes in
T13166 1703-1714 JJ denotes endothelial
T13167 1715-1720 NNS denotes cells
T13168 1720-1721 , denotes ,
T13169 1722-1725 CC denotes and
T13170 1726-1729 PRP$ denotes its
T13171 1730-1746 NN denotes immunoreactivity
T13172 1747-1753 VBD denotes showed
T13173 1754-1756 DT denotes an
T13174 1757-1764 JJ denotes inverse
T13175 1765-1776 NN denotes correlation
T13176 1777-1779 TO denotes to
T13177 1780-1783 DT denotes the
T13178 1784-1790 NN denotes degree
T13179 1791-1793 IN denotes of
T13180 1794-1800 NNP denotes SMI-71
T13181 1801-1811 NN denotes expression
T13182 1811-1812 . denotes .
T13183 1813-1819 CD denotes SMI-71
T13184 1819-1820 , denotes ,
T13185 1821-1823 DT denotes an
T13186 1824-1835 JJ denotes endothelial
T13187 1836-1843 NN denotes barrier
T13188 1844-1851 NN denotes antigen
T13189 1851-1852 , denotes ,
T13190 1853-1855 VBZ denotes is
T13191 1856-1857 DT denotes a
T13192 1858-1865 NN denotes protein
T13193 1866-1875 VBN denotes expressed
T13194 1876-1878 IN denotes by
T13195 1879-1890 JJ denotes endothelial
T13196 1891-1896 NNS denotes cells
T13197 1897-1899 IN denotes of
T13198 1900-1903 NN denotes rat
T13199 1904-1907 NNP denotes BBB
T13200 1908-1909 NNP denotes [
T13201 1909-1911 CD denotes 31
T13202 1911-1912 NNP denotes ]
T13203 1912-1913 . denotes .
T13204 1914-1919 IN denotes Under
T13205 1920-1932 JJ denotes pathological
T13206 1933-1943 NNS denotes conditions
T13207 1943-1944 , denotes ,
T13208 1945-1951 NNP denotes SMI-71
T13209 1952-1962 NN denotes expression
T13210 1963-1965 VBZ denotes is
T13211 1966-1970 VBN denotes lost
T13212 1971-1973 IN denotes in
T13213 1974-1985 JJ denotes endothelial
T13214 1986-1991 NNS denotes cells
T13215 1992-1993 NNP denotes [
T13216 1993-2004 CD denotes 5,7,8,30,32
T13217 2004-2005 NNP denotes ]
T13218 2005-2006 . denotes .
T13219 2007-2012 JJ denotes Acute
T13220 2013-2019 NNS denotes phases
T13221 2020-2022 IN denotes of
T13222 2023-2026 DT denotes the
T13223 2027-2032 JJ denotes above
T13224 2033-2045 JJ denotes pathological
T13225 2046-2056 NNS denotes conditions
T13226 2057-2060 VBP denotes are
T13227 2061-2072 VBN denotes accompanied
T13228 2073-2075 IN denotes by
T13229 2076-2083 VBG denotes opening
T13230 2084-2086 IN denotes of
T13231 2087-2090 DT denotes the
T13232 2091-2094 NNP denotes BBB
T13233 2095-2098 CC denotes and
T13234 2099-2110 NN denotes development
T13235 2111-2113 IN denotes of
T13236 2114-2123 JJ denotes vasogenic
T13237 2124-2129 NN denotes edema
T13238 2130-2131 NNP denotes [
T13239 2131-2133 CD denotes 33
T13240 2133-2134 NNP denotes ]
T13241 2134-2135 . denotes .
T13242 2136-2142 RB denotes Indeed
T13243 2142-2143 , denotes ,
T13244 2144-2158 NN denotes neutralization
T13245 2159-2161 IN denotes of
T13246 2162-2168 NN denotes SMI-71
T13247 2169-2171 IN denotes in
T13248 2172-2176 NN denotes vivo
T13249 2177-2182 VBZ denotes leads
T13250 2183-2185 TO denotes to
T13251 2186-2194 VBG denotes widening
T13252 2195-2197 IN denotes of
T13253 2198-2211 JJ denotes intercellular
T13254 2212-2221 NNS denotes junctions
T13255 2222-2229 IN denotes between
T13256 2230-2241 JJ denotes endothelial
T13257 2242-2247 NNS denotes cells
T13258 2248-2251 CC denotes and
T13259 2252-2260 VBG denotes swelling
T13260 2261-2263 IN denotes of
T13261 2264-2276 JJ denotes perivascular
T13262 2277-2287 JJ denotes astrocytic
T13263 2288-2297 NNS denotes processes
T13264 2298-2299 NNP denotes [
T13265 2299-2301 CD denotes 34
T13266 2301-2302 NNP denotes ]
T13267 2302-2303 , denotes ,
T13268 2304-2312 IN denotes although
T13269 2313-2319 NNP denotes SMI-71
T13270 2320-2322 VBZ denotes is
T13271 2323-2326 RB denotes not
T13272 2327-2336 VBN denotes localized
T13273 2337-2339 IN denotes at
T13274 2340-2351 JJ denotes endothelial
T13275 2352-2356 NN denotes cell
T13276 2357-2366 NNS denotes junctions
T13277 2367-2368 NNP denotes [
T13278 2368-2373 CD denotes 35-38
T13279 2373-2374 NNP denotes ]
T13280 2374-2375 . denotes .
T13281 2376-2378 IN denotes In
T13282 2379-2382 DT denotes the
T13283 2383-2390 JJ denotes present
T13284 2391-2396 NN denotes study
T13285 2396-2397 , denotes ,
T13286 2398-2404 NNP denotes SMI-71
T13287 2405-2421 NN denotes immunoreactivity
T13288 2422-2425 VBD denotes was
T13289 2426-2439 RB denotes significantly
T13290 2440-2447 VBN denotes reduced
T13291 2448-2450 IN denotes in
T13292 2451-2456 NN denotes blood
T13293 2457-2464 NNS denotes vessels
T13294 2465-2466 CD denotes 1
T13295 2467-2470 NN denotes day
T13296 2471-2476 IN denotes after
T13297 2477-2479 NNP denotes SE
T13298 2480-2484 WRB denotes when
T13299 2485-2494 JJ denotes vasogenic
T13300 2495-2500 NN denotes edema
T13301 2501-2504 CC denotes and
T13302 2505-2513 JJ denotes neuronal
T13303 2514-2520 NN denotes damage
T13304 2521-2525 VBD denotes were
T13305 2526-2534 VBN denotes observed
T13306 2534-2535 . denotes .
T13307 2536-2547 RB denotes Furthermore
T13308 2547-2548 , denotes ,
T13309 2549-2557 JJ denotes sTNFp55R
T13310 2558-2566 NN denotes infusion
T13311 2567-2578 RB denotes effectively
T13312 2579-2588 VBD denotes prevented
T13313 2589-2599 JJ denotes SE-induced
T13314 2600-2606 NNP denotes SMI-71
T13315 2607-2622 NN denotes down-regulation
T13316 2622-2623 . denotes .
T13317 2624-2628 IN denotes With
T13318 2629-2636 NN denotes respect
T13319 2637-2639 TO denotes to
T13320 2640-2643 DT denotes the
T13321 2644-2659 NN denotes phosphorylation
T13322 2660-2662 IN denotes of
T13323 2663-2673 NN denotes p65-Thr435
T13324 2674-2676 IN denotes by
T13325 2677-2682 NNP denotes TNF-α
T13326 2683-2684 NNP denotes [
T13327 2684-2686 CD denotes 39
T13328 2686-2687 NNP denotes ]
T13329 2687-2688 , denotes ,
T13330 2689-2692 PRP$ denotes our
T13331 2693-2701 NNS denotes findings
T13332 2702-2710 VBP denotes indicate
T13333 2711-2715 IN denotes that
T13334 2716-2730 JJ denotes TNF-α-mediated
T13335 2731-2741 NN denotes p65-Thr435
T13336 2742-2757 NN denotes phosphorylation
T13337 2758-2760 IN denotes in
T13338 2761-2772 JJ denotes endothelial
T13339 2773-2778 NNS denotes cells
T13340 2779-2782 MD denotes may
T13341 2783-2787 VB denotes play
T13342 2788-2790 DT denotes an
T13343 2791-2800 JJ denotes important
T13344 2801-2805 NN denotes role
T13345 2806-2808 IN denotes in
T13346 2809-2818 JJ denotes vasogenic
T13347 2819-2824 NN denotes edema
T13348 2825-2834 NN denotes induction
T13349 2835-2838 IN denotes via
T13350 2839-2845 NNP denotes SMI-71
T13351 2846-2857 NN denotes degradation
T13352 2858-2860 CC denotes or
T13353 2861-2864 PRP$ denotes its
T13354 2865-2882 JJ denotes posttranslational
T13355 2883-2894 NN denotes dysfunction
T13356 2895-2906 VBG denotes influencing
T13357 2907-2910 NNP denotes BBB
T13358 2911-2923 NN denotes permeability
T13359 2923-2924 . denotes .
T13360 2925-2927 IN denotes In
T13361 2928-2931 PRP$ denotes our
T13362 2932-2940 JJ denotes previous
T13363 2941-2948 NNS denotes studies
T13364 2949-2950 NNP denotes [
T13365 2950-2953 CD denotes 5,8
T13366 2953-2954 NNP denotes ]
T13367 2954-2955 , denotes ,
T13368 2956-2966 NN denotes dystrophin
T13369 2967-2968 -LRB- denotes (
T13370 2968-2970 DT denotes an
T13371 2971-2984 NN denotes actin-binding
T13372 2985-2992 NN denotes protein
T13373 2993-2994 NNP denotes [
T13374 2994-2996 CD denotes 40
T13375 2996-2997 NNP denotes ]
T13376 2997-2998 -RRB- denotes )
T13377 2999-3015 NN denotes immunoreactivity
T13378 3016-3019 VBD denotes was
T13379 3020-3028 VBN denotes detected
T13380 3029-3031 IN denotes in
T13381 3032-3037 NN denotes blood
T13382 3038-3045 NNS denotes vessels
T13383 3046-3049 CC denotes and
T13384 3050-3052 IN denotes in
T13385 3053-3063 JJ denotes astrocytic
T13386 3064-3076 JJ denotes perivascular
T13387 3077-3085 NN denotes end-feet
T13388 3085-3086 , denotes ,
T13389 3087-3090 CC denotes and
T13390 3091-3094 VBD denotes was
T13391 3095-3109 JJ denotes down-regulated
T13392 3110-3112 CD denotes 12
T13393 3113-3116 NNS denotes hrs
T13394 3117-3122 IN denotes after
T13395 3123-3125 NNP denotes SE
T13396 3126-3131 RB denotes prior
T13397 3132-3134 TO denotes to
T13398 3135-3138 DT denotes the
T13399 3139-3149 NN denotes appearance
T13400 3150-3152 IN denotes of
T13401 3153-3162 JJ denotes vasogenic
T13402 3163-3168 NN denotes edema
T13403 3169-3172 CC denotes and
T13404 3173-3188 NN denotes down-regulation
T13405 3189-3191 IN denotes of
T13406 3192-3198 NNP denotes SMI-71
T13407 3199-3215 NN denotes immunoreactivity
T13408 3215-3216 . denotes .
T13409 3217-3221 IN denotes With
T13410 3222-3229 NN denotes respect
T13411 3230-3232 TO denotes to
T13412 3233-3237 DT denotes this
T13413 3238-3246 JJ denotes previous
T13414 3247-3253 NN denotes report
T13415 3253-3254 , denotes ,
T13416 3255-3262 NNS denotes changes
T13417 3263-3265 IN denotes in
T13418 3266-3269 NNP denotes SMI
T13419 3270-3286 NN denotes immunoreactivity
T13420 3287-3292 MD denotes would
T13421 3293-3295 VB denotes be
T13422 3296-3310 NNS denotes causes/results
T13423 3311-3313 IN denotes of
T13424 3314-3325 NN denotes interaction
T13425 3326-3333 IN denotes between
T13426 3334-3345 JJ denotes endothelial
T13427 3346-3351 NNS denotes cells
T13428 3352-3355 CC denotes and
T13429 3356-3368 JJ denotes perivascular
T13430 3369-3379 NNS denotes astrocytes
T13431 3379-3380 . denotes .
T13432 3381-3383 IN denotes In
T13433 3384-3387 DT denotes the
T13434 3388-3395 JJ denotes present
T13435 3396-3401 NN denotes study
T13436 3401-3402 , denotes ,
T13437 3403-3413 NN denotes p65-Ser276
T13438 3413-3414 , denotes ,
T13439 3415-3425 NN denotes p65-Ser311
T13440 3425-3426 , denotes ,
T13441 3427-3437 NN denotes p65-Ser529
T13442 3437-3438 , denotes ,
T13443 3439-3442 CC denotes and
T13444 3443-3453 NNP denotes p65-Ser536
T13445 3454-3469 NN denotes phosphorylation
T13446 3470-3473 VBD denotes was
T13447 3474-3482 VBN denotes observed
T13448 3483-3485 IN denotes in
T13449 3486-3496 NNS denotes astrocytes
T13450 3497-3506 VBG denotes following
T13451 3507-3509 NNP denotes SE
T13452 3509-3510 . denotes .
T13453 3511-3522 RB denotes Furthermore
T13454 3522-3523 , denotes ,
T13455 3524-3532 JJ denotes sTNFp55R
T13456 3533-3541 NN denotes infusion
T13457 3542-3553 RB denotes effectively
T13458 3554-3563 VBD denotes inhibited
T13459 3564-3574 NN denotes p65-Ser276
T13460 3575-3578 CC denotes and
T13461 3579-3604 NN denotes p65-Ser311phosphorylation
T13462 3605-3607 IN denotes in
T13463 3608-3618 NNS denotes astrocytes
T13464 3619-3628 VBG denotes following
T13465 3629-3631 NNP denotes SE
T13466 3631-3632 . denotes .
T13467 3633-3642 RB denotes Therefore
T13468 3642-3643 , denotes ,
T13469 3644-3646 PRP denotes it
T13470 3647-3649 VBZ denotes is
T13471 3650-3656 JJ denotes likely
T13472 3657-3661 IN denotes that
T13473 3662-3670 JJ denotes enhanced
T13474 3671-3681 NN denotes p65-Ser276
T13475 3682-3685 CC denotes and
T13476 3686-3696 NN denotes p65-Ser311
T13477 3697-3712 NN denotes phosphorylation
T13478 3713-3716 MD denotes may
T13479 3717-3719 VB denotes be
T13480 3720-3728 VBN denotes involved
T13481 3729-3731 IN denotes in
T13482 3732-3746 JJ denotes TNF-α-mediated
T13483 3747-3750 NNP denotes BBB
T13484 3751-3761 NN denotes disruption
T13485 3761-3762 . denotes .
T13486 3763-3770 RB denotes However
T13487 3770-3771 , denotes ,
T13488 3772-3780 JJ denotes sTNFp55R
T13489 3781-3789 NN denotes infusion
T13490 3790-3795 MD denotes could
T13491 3796-3799 RB denotes not
T13492 3800-3807 VB denotes prevent
T13493 3808-3818 NN denotes p65-Ser529
T13494 3819-3822 CC denotes and
T13495 3823-3833 NN denotes p65-Ser536
T13496 3834-3850 NNS denotes phosphorylations
T13497 3851-3855 IN denotes from
T13498 3856-3858 JJ denotes SE
T13499 3859-3866 NNS denotes insults
T13500 3866-3867 . denotes .
T13501 3868-3873 IN denotes Since
T13502 3874-3884 NN denotes p65-Ser529
T13503 3885-3888 CC denotes and
T13504 3889-3899 NN denotes p65-Ser536
T13505 3900-3903 VBP denotes are
T13506 3904-3918 VBN denotes phosphorylated
T13507 3919-3921 IN denotes by
T13508 3922-3927 NNP denotes TNF-α
T13509 3928-3931 CC denotes and
T13510 3932-3937 NNP denotes IL-1β
T13511 3938-3939 NNP denotes [
T13512 3939-3941 CD denotes 41
T13513 3941-3942 NNP denotes ]
T13514 3942-3943 , denotes ,
T13515 3944-3946 PRP denotes it
T13516 3947-3949 VBZ denotes is
T13517 3950-3956 JJ denotes likely
T13518 3957-3961 IN denotes that
T13519 3962-3976 JJ denotes IL-1β-mediated
T13520 3977-3987 JJ denotes p65-Ser529
T13521 3987-3988 NN denotes /
T13522 3988-3994 NNP denotes Ser536
T13523 3995-4010 NN denotes phosphorylation
T13524 4011-4014 MD denotes may
T13525 4015-4019 RB denotes also
T13526 4020-4024 VB denotes play
T13527 4025-4026 DT denotes a
T13528 4027-4031 NN denotes role
T13529 4032-4034 IN denotes in
T13530 4035-4045 JJ denotes SE-induced
T13531 4046-4055 JJ denotes vasogenic
T13532 4056-4061 NN denotes edema
T13533 4061-4062 . denotes .
T13534 4063-4072 RB denotes Therefore
T13535 4072-4073 , denotes ,
T13536 4074-4077 PRP$ denotes our
T13537 4078-4086 NNS denotes findings
T13538 4087-4095 VBP denotes indicate
T13539 4096-4100 IN denotes that
T13540 4101-4105 DT denotes both
T13541 4106-4111 NNP denotes TNF-α
T13542 4112-4115 CC denotes and
T13543 4116-4121 NNP denotes IL-1β
T13544 4122-4125 MD denotes may
T13545 4126-4128 VB denotes be
T13546 4129-4139 NNS denotes synergists
T13547 4140-4142 TO denotes to
T13548 4143-4147 VB denotes play
T13549 4148-4154 CC denotes either
T13550 4155-4156 DT denotes a
T13551 4157-4163 JJ denotes direct
T13552 4164-4165 -LRB- denotes (
T13553 4165-4167 IN denotes by
T13554 4168-4179 JJ denotes endothelial
T13555 4180-4185 NNS denotes cells
T13556 4185-4186 -RRB- denotes )
T13557 4187-4189 CC denotes or
T13558 4190-4198 JJ denotes indirect
T13559 4199-4200 -LRB- denotes (
T13560 4200-4202 IN denotes by
T13561 4203-4213 NNS denotes astrocytes
T13562 4213-4214 -RRB- denotes )
T13563 4215-4219 NN denotes role
T13564 4220-4222 IN denotes in
T13565 4223-4226 DT denotes the
T13566 4227-4238 NN denotes maintenance
T13567 4239-4241 IN denotes of
T13568 4242-4245 NNP denotes BBB
T13569 4246-4258 NN denotes permeability
T13570 4258-4259 . denotes .
T13571 4260-4270 NNP denotes Neutrophil
T13572 4271-4283 NN denotes infiltration
T13573 4284-4288 IN denotes into
T13574 4289-4294 NN denotes brain
T13575 4295-4305 NN denotes parenchyma
T13576 4306-4308 VBZ denotes is
T13577 4309-4320 RB denotes transiently
T13578 4321-4329 VBN denotes observed
T13579 4330-4336 IN denotes during
T13580 4337-4340 DT denotes the
T13581 4341-4346 JJ denotes acute
T13582 4347-4352 NN denotes phase
T13583 4353-4355 IN denotes of
T13584 4356-4358 NNP denotes SE
T13585 4359-4360 -LRB- denotes (
T13586 4360-4361 LS denotes 4
T13587 4362-4363 : denotes -
T13588 4364-4366 CD denotes 36
T13589 4367-4369 NN denotes hr
T13590 4370-4375 IN denotes after
T13591 4376-4378 NNP denotes SE
T13592 4378-4379 -RRB- denotes )
T13593 4380-4383 CC denotes and
T13594 4384-4394 VBZ denotes disappears
T13595 4395-4405 RB denotes thereafter
T13596 4406-4407 JJ denotes [
T13597 4407-4409 CD denotes 20
T13598 4409-4410 NN denotes ]
T13599 4410-4411 . denotes .
T13600 4412-4414 RB denotes SE
T13601 4415-4422 RB denotes rapidly
T13602 4423-4432 VBZ denotes increases
T13603 4433-4442 NN denotes synthesis
T13604 4443-4446 CC denotes and
T13605 4447-4454 NN denotes release
T13606 4455-4457 IN denotes of
T13607 4458-4468 NNS denotes chemokines
T13608 4469-4471 IN denotes in
T13609 4472-4479 JJ denotes various
T13610 4480-4485 NNS denotes areas
T13611 4486-4488 IN denotes of
T13612 4489-4492 DT denotes the
T13613 4493-4499 NN denotes rodent
T13614 4500-4505 NN denotes brain
T13615 4506-4507 NNP denotes [
T13616 4507-4509 CD denotes 42
T13617 4509-4510 NNP denotes ]
T13618 4510-4511 . denotes .
T13619 4512-4517 IN denotes Among
T13620 4518-4522 PRP denotes them
T13621 4522-4523 , denotes ,
T13622 4524-4529 NNP denotes MIP-2
T13623 4530-4532 VBZ denotes is
T13624 4533-4541 VBN denotes required
T13625 4542-4545 IN denotes for
T13626 4546-4555 JJ denotes efficient
T13627 4556-4566 NN denotes neutrophil
T13628 4567-4569 CC denotes or
T13629 4570-4580 NN denotes lymphocyte
T13630 4581-4592 NN denotes recruitment
T13631 4593-4595 TO denotes to
T13632 4596-4601 NN denotes brain
T13633 4602-4612 NN denotes parenchyma
T13634 4613-4614 NNP denotes [
T13635 4614-4616 CD denotes 43
T13636 4616-4617 NNP denotes ]
T13637 4617-4618 . denotes .
T13638 4619-4621 IN denotes In
T13639 4622-4625 PRP$ denotes our
T13640 4626-4634 JJ denotes previous
T13641 4635-4640 NN denotes study
T13642 4641-4642 NNP denotes [
T13643 4642-4644 CD denotes 20
T13644 4644-4645 NNP denotes ]
T13645 4645-4646 , denotes ,
T13646 4647-4657 NN denotes neutrophil
T13647 4658-4670 NN denotes infiltration
T13648 4671-4673 IN denotes in
T13649 4674-4677 DT denotes the
T13650 4678-4692 JJ denotes frontoparietal
T13651 4693-4699 NN denotes cortex
T13652 4700-4703 VBD denotes was
T13653 4704-4713 VBN denotes regulated
T13654 4714-4716 IN denotes by
T13655 4717-4721 NNP denotes P2X7
T13656 4722-4739 VBD denotes receptor-mediated
T13657 4740-4745 NNP denotes MIP-2
T13658 4746-4756 NN denotes expression
T13659 4756-4757 . denotes .
T13660 4758-4760 IN denotes In
T13661 4761-4764 DT denotes the
T13662 4765-4767 NN denotes PC
T13663 4767-4768 , denotes ,
T13664 4769-4776 RB denotes however
T13665 4776-4777 , denotes ,
T13666 4778-4785 DT denotes neither
T13667 4786-4787 DT denotes a
T13668 4788-4792 NN denotes P2X7
T13669 4793-4801 NN denotes receptor
T13670 4802-4820 JJ denotes agonist/antagonist
T13671 4821-4824 CC denotes nor
T13672 4825-4831 JJ denotes IL-1Ra
T13673 4832-4833 -LRB- denotes (
T13674 4833-4835 DT denotes an
T13675 4836-4841 NN denotes IL-1β
T13676 4842-4852 NN denotes antagonist
T13677 4852-4853 -RRB- denotes )
T13678 4854-4862 NN denotes infusion
T13679 4863-4868 MD denotes could
T13680 4869-4872 RB denotes not
T13681 4873-4879 VB denotes affect
T13682 4880-4889 JJ denotes leukocyte
T13683 4890-4902 NN denotes infiltration
T13684 4902-4903 . denotes .
T13685 4904-4906 IN denotes In
T13686 4907-4910 DT denotes the
T13687 4911-4918 JJ denotes present
T13688 4919-4924 NN denotes study
T13689 4924-4925 , denotes ,
T13690 4926-4934 JJ denotes sTNFp55R
T13691 4935-4943 NN denotes infusion
T13692 4944-4955 RB denotes effectively
T13693 4956-4965 VBD denotes inhibited
T13694 4966-4976 NN denotes neutrophil
T13695 4977-4989 NN denotes infiltration
T13696 4990-4992 IN denotes in
T13697 4993-4996 DT denotes the
T13698 4997-4999 NN denotes PC
T13699 5000-5002 IN denotes by
T13700 5003-5011 VBG denotes reducing
T13701 5012-5021 JJ denotes vasogenic
T13702 5022-5027 NN denotes edema
T13703 5028-5037 NN denotes formation
T13704 5038-5040 IN denotes in
T13705 5041-5042 DT denotes a
T13706 5043-5060 JJ denotes MIP-2-independent
T13707 5061-5067 NN denotes manner
T13708 5067-5068 . denotes .
T13709 5069-5073 IN denotes With
T13710 5074-5081 NN denotes respect
T13711 5082-5084 TO denotes to
T13712 5085-5088 DT denotes the
T13713 5089-5096 JJ denotes present
T13714 5097-5100 CC denotes and
T13715 5101-5104 PRP$ denotes our
T13716 5105-5113 JJ denotes previous
T13717 5114-5121 NNS denotes reports
T13718 5121-5122 , denotes ,
T13719 5123-5125 PRP denotes it
T13720 5126-5128 VBZ denotes is
T13721 5129-5138 RB denotes therefore
T13722 5139-5145 JJ denotes likely
T13723 5146-5150 IN denotes that
T13724 5151-5160 JJ denotes vasogenic
T13725 5161-5166 NN denotes edema
T13726 5167-5174 VBN denotes induced
T13727 5175-5177 IN denotes by
T13728 5178-5183 NNP denotes TNF-α
T13729 5184-5187 MD denotes can
T13730 5188-5194 VB denotes induce
T13731 5195-5205 NN denotes neutrophil
T13732 5206-5218 NN denotes infiltration
T13733 5219-5222 CC denotes and
T13734 5223-5228 NN denotes press
T13735 5229-5235 NN denotes injury
T13736 5236-5238 TO denotes to
T13737 5239-5244 VB denotes evoke
T13738 5245-5264 JJ denotes neuronal-astroglial
T13739 5265-5269 NN denotes loss
T13740 5270-5272 IN denotes in
T13741 5273-5276 DT denotes the
T13742 5277-5279 NN denotes PC
T13743 5279-5280 , denotes ,
T13744 5281-5287 IN denotes unlike
T13745 5288-5293 JJ denotes other
T13746 5294-5299 NN denotes brain
T13747 5300-5307 NNS denotes regions
T13748 5307-5308 . denotes .
T13749 5309-5311 IN denotes In
T13750 5312-5322 NN denotes conclusion
T13751 5322-5323 , denotes ,
T13752 5324-5327 PRP$ denotes our
T13753 5328-5336 NNS denotes findings
T13754 5337-5343 VBP denotes reveal
T13755 5344-5348 IN denotes that
T13756 5349-5360 NNS denotes impairments
T13757 5361-5363 IN denotes of
T13758 5364-5375 JJ denotes endothelial
T13759 5376-5380 NN denotes cell
T13760 5381-5389 NN denotes function
T13761 5390-5393 IN denotes via
T13762 5394-5399 NNP denotes TNF-α
T13763 5400-5408 VBD denotes mediated
T13764 5409-5416 JJ denotes p65-Thr
T13765 5417-5420 CD denotes 435
T13766 5421-5426 JJ denotes NF-κB
T13767 5427-5442 NN denotes phosphorylation
T13768 5443-5446 MD denotes may
T13769 5447-5449 VB denotes be
T13770 5450-5458 VBN denotes involved
T13771 5459-5461 IN denotes in
T13772 5462-5472 JJ denotes SE-induced
T13773 5473-5482 JJ denotes vasogenic
T13774 5483-5488 NN denotes edema
T13775 5488-5489 , denotes ,
T13776 5490-5495 WDT denotes which
T13777 5496-5498 VBZ denotes is
T13778 5499-5507 JJ denotes relevant
T13779 5508-5510 TO denotes to
T13780 5511-5521 NN denotes neutrophil
T13781 5522-5534 NN denotes infiltration
T13782 5535-5538 CC denotes and
T13783 5539-5558 JJ denotes neuronal-astroglial
T13784 5559-5563 NN denotes loss
T13785 5563-5564 . denotes .
R10080 T12893 T12895 det The,findings
R10081 T12894 T12895 amod major,findings
R10082 T12895 T12900 nsubj findings,are
R10083 T12896 T12895 prep in,findings
R10084 T12897 T12899 det the,study
R10085 T12898 T12899 amod present,study
R10086 T12899 T12896 pobj study,in
R10087 T12900 T12900 ROOT are,are
R10088 T12901 T12904 mark that,showed
R10089 T12902 T12904 nsubj TNF-α,showed
R10090 T12903 T12902 acl signaling,TNF-α
R10091 T12904 T12900 ccomp showed,are
R10092 T12905 T12907 amod cellular,responses
R10093 T12906 T12907 amod specific,responses
R10094 T12907 T12904 dobj responses,showed
R10095 T12908 T12907 prep of,responses
R10096 T12909 T12910 amod NF-κB,phosphorylation
R10097 T12910 T12908 pobj phosphorylation,of
R10098 T12911 T12910 prep in,phosphorylation
R10099 T12912 T12913 det the,PC
R10100 T12913 T12911 pobj PC,in
R10101 T12914 T12907 prep following,responses
R10102 T12915 T12914 pobj SE,following
R10103 T12916 T12915 punct ",",SE
R10104 T12917 T12920 nsubjpass which,related
R10105 T12918 T12920 aux may,related
R10106 T12919 T12920 auxpass be,related
R10107 T12920 T12915 relcl related,SE
R10108 T12921 T12920 prep to,related
R10109 T12922 T12924 amod vasogenic,formation
R10110 T12923 T12924 compound edema,formation
R10111 T12924 T12921 pobj formation,to
R10112 T12925 T12924 acl followed,formation
R10113 T12926 T12925 agent by,followed
R10114 T12927 T12928 compound neutrophil,infiltration
R10115 T12928 T12926 pobj infiltration,by
R10116 T12929 T12900 punct .,are
R10117 T12930 T12931 compound BBB,disruption
R10118 T12931 T12934 nsubjpass disruption,reported
R10119 T12932 T12934 aux has,reported
R10120 T12933 T12934 auxpass been,reported
R10121 T12934 T12934 ROOT reported,reported
R10122 T12935 T12934 prep in,reported
R10123 T12936 T12939 amod experimental,epilepsy
R10124 T12937 T12936 cc and,experimental
R10125 T12938 T12936 conj human,experimental
R10126 T12939 T12935 pobj epilepsy,in
R10127 T12940 T12942 compound [,]
R10128 T12941 T12942 compound "12,13,15,16,28",]
R10129 T12942 T12934 npadvmod ],reported
R10130 T12943 T12934 punct .,reported
R10131 T12944 T12953 nsubjpass Leakage,associated
R10132 T12945 T12944 prep of,Leakage
R10133 T12946 T12947 amod serum-derived,components
R10134 T12947 T12945 pobj components,of
R10135 T12948 T12944 prep into,Leakage
R10136 T12949 T12951 det the,space
R10137 T12950 T12951 amod extracellular,space
R10138 T12951 T12948 pobj space,into
R10139 T12952 T12953 auxpass is,associated
R10140 T12953 T12953 ROOT associated,associated
R10141 T12954 T12953 prep with,associated
R10142 T12955 T12954 pobj hyperexcitability,with
R10143 T12956 T12955 cc and,hyperexcitability
R10144 T12957 T12958 compound seizure,onset
R10145 T12958 T12955 conj onset,hyperexcitability
R10146 T12959 T12961 compound [,]
R10147 T12960 T12961 compound "12,13,15,16,28",]
R10148 T12961 T12955 appos ],hyperexcitability
R10149 T12962 T12953 punct .,associated
R10150 T12963 T12969 advmod Furthermore,leads
R10151 T12964 T12969 punct ",",leads
R10152 T12965 T12969 nsubj dysfunction,leads
R10153 T12966 T12965 prep of,dysfunction
R10154 T12967 T12968 det the,BBB
R10155 T12968 T12966 pobj BBB,of
R10156 T12969 T12969 ROOT leads,leads
R10157 T12970 T12971 aux to,epileptogenesis
R10158 T12971 T12969 xcomp epileptogenesis,leads
R10159 T12972 T12969 cc and,leads
R10160 T12973 T12969 conj contributes,leads
R10161 T12974 T12973 prep to,contributes
R10162 T12975 T12974 pobj progression,to
R10163 T12976 T12975 prep of,progression
R10164 T12977 T12976 pobj epilepsy,of
R10165 T12978 T12980 compound [,]
R10166 T12979 T12980 compound "12,13,15,16,28",]
R10167 T12980 T12975 appos ],progression
R10168 T12981 T12969 punct .,leads
R10169 T12982 T12991 prep In,observed
R10170 T12983 T12985 det the,study
R10171 T12984 T12985 amod present,study
R10172 T12985 T12982 pobj study,In
R10173 T12986 T12991 punct ",",observed
R10174 T12987 T12988 amod TNF-α,immunoreactivity
R10175 T12988 T12991 nsubjpass immunoreactivity,observed
R10176 T12989 T12991 auxpass was,observed
R10177 T12990 T12991 advmod obviously,observed
R10178 T12991 T12991 ROOT observed,observed
R10179 T12992 T12991 prep in,observed
R10180 T12993 T12992 pobj microglia,in
R10181 T12994 T12991 prep in,observed
R10182 T12995 T12996 det the,PC
R10183 T12996 T12994 pobj PC,in
R10184 T12997 T12991 prep following,observed
R10185 T12998 T12997 dobj SE,following
R10186 T12999 T12991 punct .,observed
R10187 T13000 T13002 compound TNF,expressions
R10188 T13001 T13002 compound receptor,expressions
R10189 T13002 T13003 nsubj expressions,were
R10190 T13003 T13003 ROOT were,were
R10191 T13004 T13003 advmod also,were
R10192 T13005 T13003 acomp up-regulated,were
R10193 T13006 T13005 prep in,up-regulated
R10194 T13007 T13006 pobj astrocytes,in
R10195 T13008 T13007 punct (,astrocytes
R10196 T13009 T13007 appos TNFp55R,astrocytes
R10197 T13010 T13009 cc and,TNFp55R
R10198 T13011 T13015 nmod TNFp75R,cells
R10199 T13012 T13011 punct ),TNFp75R
R10200 T13013 T13011 cc and,TNFp75R
R10201 T13014 T13011 conj endothelial,TNFp75R
R10202 T13015 T13009 conj cells,TNFp55R
R10203 T13016 T13015 punct (,cells
R10204 T13017 T13015 appos TNFp75R,cells
R10205 T13018 T13015 punct ),cells
R10206 T13019 T13003 punct .,were
R10207 T13020 T13035 advmod Furthermore,reduced
R10208 T13021 T13035 punct ",",reduced
R10209 T13022 T13035 nsubj blockade,reduced
R10210 T13023 T13022 prep of,blockade
R10211 T13024 T13023 pobj TNF-α,of
R10212 T13025 T13022 acl signaling,blockade
R10213 T13026 T13025 prep by,signaling
R10214 T13027 T13026 pobj sTNFp55,by
R10215 T13028 T13035 nsubj infusion,reduced
R10216 T13029 T13035 advmod effectively,reduced
R10217 T13030 T13029 punct (,effectively
R10218 T13031 T13035 cc but,reduced
R10219 T13032 T13033 neg not,completely
R10220 T13033 T13035 advmod completely,reduced
R10221 T13034 T13035 punct ),reduced
R10222 T13035 T13035 ROOT reduced,reduced
R10223 T13036 T13035 dobj volumes,reduced
R10224 T13037 T13036 prep of,volumes
R10225 T13038 T13040 amod SE-induced,edema
R10226 T13039 T13040 amod vasogenic,edema
R10227 T13040 T13037 pobj edema,of
R10228 T13041 T13040 cc and,edema
R10229 T13042 T13043 amod neuronal,damage
R10230 T13043 T13040 conj damage,edema
R10231 T13044 T13043 prep in,damage
R10232 T13045 T13046 det the,PC
R10233 T13046 T13044 pobj PC,in
R10234 T13047 T13035 punct .,reduced
R10235 T13048 T13049 det These,findings
R10236 T13049 T13050 nsubj findings,indicate
R10237 T13050 T13050 ROOT indicate,indicate
R10238 T13051 T13054 mark that,participate
R10239 T13052 T13054 nsubj TNF-α,participate
R10240 T13053 T13054 aux may,participate
R10241 T13054 T13050 ccomp participate,indicate
R10242 T13055 T13054 prep in,participate
R10243 T13056 T13059 amod astroglial,responses
R10244 T13057 T13056 cc and,astroglial
R10245 T13058 T13056 conj endothelial,astroglial
R10246 T13059 T13055 pobj responses,in
R10247 T13060 T13059 prep to,responses
R10248 T13061 T13060 pobj SE,to
R10249 T13062 T13061 punct ",",SE
R10250 T13063 T13064 nsubj which,are
R10251 T13064 T13061 relcl are,SE
R10252 T13065 T13064 acomp relevant,are
R10253 T13066 T13065 prep to,relevant
R10254 T13067 T13070 amod SE-induced,formation
R10255 T13068 T13070 amod vasogenic,formation
R10256 T13069 T13070 compound edema,formation
R10257 T13070 T13066 pobj formation,to
R10258 T13071 T13073 nmod [,]
R10259 T13072 T13073 nummod 5-8,]
R10260 T13073 T13070 appos ],formation
R10261 T13074 T13050 punct .,indicate
R10262 T13075 T13078 advmod Indeed,signaling
R10263 T13076 T13078 punct ",",signaling
R10264 T13077 T13078 amod TNF-α,signaling
R10265 T13078 T13078 ROOT signaling,signaling
R10266 T13079 T13081 nmod increases,permeability
R10267 T13080 T13081 compound BBB,permeability
R10268 T13081 T13078 dobj permeability,signaling
R10269 T13082 T13081 prep in,permeability
R10270 T13083 T13086 amod various,models
R10271 T13084 T13086 amod experimental,models
R10272 T13085 T13086 compound disease,models
R10273 T13086 T13082 pobj models,in
R10274 T13087 T13089 quantmod [,]
R10275 T13088 T13089 nummod 29,]
R10276 T13089 T13078 nsubj ],signaling
R10277 T13090 T13078 punct .,signaling
R10278 T13091 T13101 prep In,prevent
R10279 T13092 T13094 det the,study
R10280 T13093 T13094 amod present,study
R10281 T13094 T13091 pobj study,In
R10282 T13095 T13101 punct ",",prevent
R10283 T13096 T13097 amod sTNFp55,infusion
R10284 T13097 T13101 nsubj infusion,prevent
R10285 T13098 T13101 aux could,prevent
R10286 T13099 T13101 neg not,prevent
R10287 T13100 T13101 advmod completely,prevent
R10288 T13101 T13101 ROOT prevent,prevent
R10289 T13102 T13104 nmod SE-induced,edema
R10290 T13103 T13104 amod vasogenic,edema
R10291 T13104 T13101 dobj edema,prevent
R10292 T13105 T13104 cc and,edema
R10293 T13106 T13107 amod neuronal,damage
R10294 T13107 T13104 conj damage,edema
R10295 T13108 T13107 prep in,damage
R10296 T13109 T13110 det the,PC
R10297 T13110 T13108 pobj PC,in
R10298 T13111 T13101 punct .,prevent
R10299 T13112 T13116 advmod Therefore,suggest
R10300 T13113 T13116 punct ",",suggest
R10301 T13114 T13115 poss our,findings
R10302 T13115 T13116 nsubj findings,suggest
R10303 T13116 T13116 ROOT suggest,suggest
R10304 T13117 T13122 mark that,be
R10305 T13118 T13119 amod TNF-α,signaling
R10306 T13119 T13122 csubj signaling,be
R10307 T13120 T13122 aux may,be
R10308 T13121 T13122 neg not,be
R10309 T13122 T13116 ccomp be,suggest
R10310 T13123 T13126 det a,event
R10311 T13124 T13126 amod unique,event
R10312 T13125 T13126 compound upstream,event
R10313 T13126 T13122 attr event,be
R10314 T13127 T13126 prep in,event
R10315 T13128 T13130 amod vasogenic,development
R10316 T13129 T13130 compound edema,development
R10317 T13130 T13127 pobj development,in
R10318 T13131 T13116 punct .,suggest
R10319 T13132 T13133 compound p65,phosphorylation
R10320 T13133 T13136 nsubj phosphorylation,enhances
R10321 T13134 T13133 prep of,phosphorylation
R10322 T13135 T13134 pobj NF-κB,of
R10323 T13136 T13136 ROOT enhances,enhances
R10324 T13137 T13139 poss its,potential
R10325 T13138 T13139 compound transactivation,potential
R10326 T13139 T13136 dobj potential,enhances
R10327 T13140 T13136 punct ",",enhances
R10328 T13141 T13136 cc and,enhances
R10329 T13142 T13144 nummod p65,occurs
R10330 T13143 T13144 nsubj phosphorylation,occurs
R10331 T13144 T13136 conj occurs,enhances
R10332 T13145 T13144 prep in,occurs
R10333 T13146 T13148 preconj either,cytoplasm
R10334 T13147 T13148 det the,cytoplasm
R10335 T13148 T13145 pobj cytoplasm,in
R10336 T13149 T13148 cc or,cytoplasm
R10337 T13150 T13151 det the,nucleus
R10338 T13151 T13148 conj nucleus,cytoplasm
R10339 T13152 T13154 quantmod [,]
R10340 T13153 T13154 nummod 30,]
R10341 T13154 T13151 appos ],nucleus
R10342 T13155 T13144 punct .,occurs
R10343 T13156 T13164 prep In,detected
R10344 T13157 T13159 det the,study
R10345 T13158 T13159 amod present,study
R10346 T13159 T13156 pobj study,In
R10347 T13160 T13164 punct ",",detected
R10348 T13161 T13162 compound p65-Thr435,immunoreactivity
R10349 T13162 T13164 nsubjpass immunoreactivity,detected
R10350 T13163 T13164 auxpass was,detected
R10351 T13164 T13164 ROOT detected,detected
R10352 T13165 T13164 prep in,detected
R10353 T13166 T13167 amod endothelial,cells
R10354 T13167 T13165 pobj cells,in
R10355 T13168 T13164 punct ",",detected
R10356 T13169 T13164 cc and,detected
R10357 T13170 T13171 poss its,immunoreactivity
R10358 T13171 T13172 nsubj immunoreactivity,showed
R10359 T13172 T13164 conj showed,detected
R10360 T13173 T13175 det an,correlation
R10361 T13174 T13175 amod inverse,correlation
R10362 T13175 T13172 dobj correlation,showed
R10363 T13176 T13175 prep to,correlation
R10364 T13177 T13178 det the,degree
R10365 T13178 T13176 pobj degree,to
R10366 T13179 T13178 prep of,degree
R10367 T13180 T13181 compound SMI-71,expression
R10368 T13181 T13179 pobj expression,of
R10369 T13182 T13172 punct .,showed
R10370 T13183 T13190 nsubj SMI-71,is
R10371 T13184 T13183 punct ",",SMI-71
R10372 T13185 T13188 det an,antigen
R10373 T13186 T13188 amod endothelial,antigen
R10374 T13187 T13188 compound barrier,antigen
R10375 T13188 T13183 appos antigen,SMI-71
R10376 T13189 T13190 punct ",",is
R10377 T13190 T13190 ROOT is,is
R10378 T13191 T13192 det a,protein
R10379 T13192 T13190 attr protein,is
R10380 T13193 T13192 acl expressed,protein
R10381 T13194 T13193 agent by,expressed
R10382 T13195 T13196 amod endothelial,cells
R10383 T13196 T13194 pobj cells,by
R10384 T13197 T13196 prep of,cells
R10385 T13198 T13199 compound rat,BBB
R10386 T13199 T13200 compound BBB,[
R10387 T13200 T13197 pobj [,of
R10388 T13201 T13202 nummod 31,]
R10389 T13202 T13196 appos ],cells
R10390 T13203 T13190 punct .,is
R10391 T13204 T13211 prep Under,lost
R10392 T13205 T13206 amod pathological,conditions
R10393 T13206 T13204 pobj conditions,Under
R10394 T13207 T13211 punct ",",lost
R10395 T13208 T13209 compound SMI-71,expression
R10396 T13209 T13211 nsubjpass expression,lost
R10397 T13210 T13211 auxpass is,lost
R10398 T13211 T13211 ROOT lost,lost
R10399 T13212 T13211 prep in,lost
R10400 T13213 T13214 amod endothelial,cells
R10401 T13214 T13212 pobj cells,in
R10402 T13215 T13217 compound [,]
R10403 T13216 T13217 compound "5,7,8,30,32",]
R10404 T13217 T13211 dobj ],lost
R10405 T13218 T13211 punct .,lost
R10406 T13219 T13220 amod Acute,phases
R10407 T13220 T13227 nsubjpass phases,accompanied
R10408 T13221 T13220 prep of,phases
R10409 T13222 T13225 det the,conditions
R10410 T13223 T13225 amod above,conditions
R10411 T13224 T13225 amod pathological,conditions
R10412 T13225 T13221 pobj conditions,of
R10413 T13226 T13227 auxpass are,accompanied
R10414 T13227 T13227 ROOT accompanied,accompanied
R10415 T13228 T13227 agent by,accompanied
R10416 T13229 T13228 pobj opening,by
R10417 T13230 T13229 prep of,opening
R10418 T13231 T13232 det the,BBB
R10419 T13232 T13230 pobj BBB,of
R10420 T13233 T13232 cc and,BBB
R10421 T13234 T13230 pobj development,of
R10422 T13235 T13234 prep of,development
R10423 T13236 T13237 amod vasogenic,edema
R10424 T13237 T13235 pobj edema,of
R10425 T13238 T13240 nmod [,]
R10426 T13239 T13240 nummod 33,]
R10427 T13240 T13237 appos ],edema
R10428 T13241 T13227 punct .,accompanied
R10429 T13242 T13249 advmod Indeed,leads
R10430 T13243 T13249 punct ",",leads
R10431 T13244 T13249 nsubj neutralization,leads
R10432 T13245 T13244 prep of,neutralization
R10433 T13246 T13245 pobj SMI-71,of
R10434 T13247 T13244 prep in,neutralization
R10435 T13248 T13247 pobj vivo,in
R10436 T13249 T13249 ROOT leads,leads
R10437 T13250 T13249 prep to,leads
R10438 T13251 T13250 pcomp widening,to
R10439 T13252 T13251 prep of,widening
R10440 T13253 T13254 amod intercellular,junctions
R10441 T13254 T13252 pobj junctions,of
R10442 T13255 T13254 prep between,junctions
R10443 T13256 T13257 amod endothelial,cells
R10444 T13257 T13255 pobj cells,between
R10445 T13258 T13257 cc and,cells
R10446 T13259 T13251 conj swelling,widening
R10447 T13260 T13259 prep of,swelling
R10448 T13261 T13263 amod perivascular,processes
R10449 T13262 T13263 amod astrocytic,processes
R10450 T13263 T13260 pobj processes,of
R10451 T13264 T13266 nmod [,]
R10452 T13265 T13266 nummod 34,]
R10453 T13266 T13250 pobj ],to
R10454 T13267 T13249 punct ",",leads
R10455 T13268 T13272 mark although,localized
R10456 T13269 T13272 nsubjpass SMI-71,localized
R10457 T13270 T13272 auxpass is,localized
R10458 T13271 T13272 neg not,localized
R10459 T13272 T13249 advcl localized,leads
R10460 T13273 T13272 prep at,localized
R10461 T13274 T13275 amod endothelial,cell
R10462 T13275 T13276 compound cell,junctions
R10463 T13276 T13273 pobj junctions,at
R10464 T13277 T13279 compound [,]
R10465 T13278 T13279 compound 35-38,]
R10466 T13279 T13272 npadvmod ],localized
R10467 T13280 T13249 punct .,leads
R10468 T13281 T13290 prep In,reduced
R10469 T13282 T13284 det the,study
R10470 T13283 T13284 amod present,study
R10471 T13284 T13281 pobj study,In
R10472 T13285 T13290 punct ",",reduced
R10473 T13286 T13287 compound SMI-71,immunoreactivity
R10474 T13287 T13290 nsubjpass immunoreactivity,reduced
R10475 T13288 T13290 auxpass was,reduced
R10476 T13289 T13290 advmod significantly,reduced
R10477 T13290 T13290 ROOT reduced,reduced
R10478 T13291 T13290 prep in,reduced
R10479 T13292 T13293 compound blood,vessels
R10480 T13293 T13291 pobj vessels,in
R10481 T13294 T13295 nummod 1,day
R10482 T13295 T13290 npadvmod day,reduced
R10483 T13296 T13305 mark after,observed
R10484 T13297 T13296 pobj SE,after
R10485 T13298 T13305 advmod when,observed
R10486 T13299 T13300 amod vasogenic,edema
R10487 T13300 T13305 nsubjpass edema,observed
R10488 T13301 T13300 cc and,edema
R10489 T13302 T13303 amod neuronal,damage
R10490 T13303 T13300 conj damage,edema
R10491 T13304 T13305 auxpass were,observed
R10492 T13305 T13295 advcl observed,day
R10493 T13306 T13290 punct .,reduced
R10494 T13307 T13312 advmod Furthermore,prevented
R10495 T13308 T13312 punct ",",prevented
R10496 T13309 T13310 amod sTNFp55R,infusion
R10497 T13310 T13312 nsubj infusion,prevented
R10498 T13311 T13312 advmod effectively,prevented
R10499 T13312 T13312 ROOT prevented,prevented
R10500 T13313 T13315 amod SE-induced,down-regulation
R10501 T13314 T13315 compound SMI-71,down-regulation
R10502 T13315 T13312 dobj down-regulation,prevented
R10503 T13316 T13312 punct .,prevented
R10504 T13317 T13332 prep With,indicate
R10505 T13318 T13317 pobj respect,With
R10506 T13319 T13318 prep to,respect
R10507 T13320 T13321 det the,phosphorylation
R10508 T13321 T13319 pobj phosphorylation,to
R10509 T13322 T13321 prep of,phosphorylation
R10510 T13323 T13322 pobj p65-Thr435,of
R10511 T13324 T13321 prep by,phosphorylation
R10512 T13325 T13326 compound TNF-α,[
R10513 T13326 T13328 nmod [,]
R10514 T13327 T13328 nummod 39,]
R10515 T13328 T13324 pobj ],by
R10516 T13329 T13332 punct ",",indicate
R10517 T13330 T13331 poss our,findings
R10518 T13331 T13332 nsubj findings,indicate
R10519 T13332 T13332 ROOT indicate,indicate
R10520 T13333 T13341 mark that,play
R10521 T13334 T13336 amod TNF-α-mediated,phosphorylation
R10522 T13335 T13336 compound p65-Thr435,phosphorylation
R10523 T13336 T13341 nsubj phosphorylation,play
R10524 T13337 T13336 prep in,phosphorylation
R10525 T13338 T13339 amod endothelial,cells
R10526 T13339 T13337 pobj cells,in
R10527 T13340 T13341 aux may,play
R10528 T13341 T13332 ccomp play,indicate
R10529 T13342 T13344 det an,role
R10530 T13343 T13344 amod important,role
R10531 T13344 T13341 dobj role,play
R10532 T13345 T13341 prep in,play
R10533 T13346 T13348 amod vasogenic,induction
R10534 T13347 T13348 compound edema,induction
R10535 T13348 T13345 pobj induction,in
R10536 T13349 T13341 prep via,play
R10537 T13350 T13351 compound SMI-71,degradation
R10538 T13351 T13349 pobj degradation,via
R10539 T13352 T13351 cc or,degradation
R10540 T13353 T13355 poss its,dysfunction
R10541 T13354 T13355 amod posttranslational,dysfunction
R10542 T13355 T13351 conj dysfunction,degradation
R10543 T13356 T13355 acl influencing,dysfunction
R10544 T13357 T13358 compound BBB,permeability
R10545 T13358 T13356 dobj permeability,influencing
R10546 T13359 T13332 punct .,indicate
R10547 T13360 T13379 prep In,detected
R10548 T13361 T13363 poss our,studies
R10549 T13362 T13363 amod previous,studies
R10550 T13363 T13360 pobj studies,In
R10551 T13364 T13366 compound [,]
R10552 T13365 T13366 compound "5,8",]
R10553 T13366 T13379 nsubjpass ],detected
R10554 T13367 T13366 punct ",",]
R10555 T13368 T13377 amod dystrophin,immunoreactivity
R10556 T13369 T13372 punct (,protein
R10557 T13370 T13372 det an,protein
R10558 T13371 T13372 compound actin-binding,protein
R10559 T13372 T13377 nmod protein,immunoreactivity
R10560 T13373 T13377 nmod [,immunoreactivity
R10561 T13374 T13375 nummod 40,]
R10562 T13375 T13373 appos ],[
R10563 T13376 T13377 punct ),immunoreactivity
R10564 T13377 T13379 nsubjpass immunoreactivity,detected
R10565 T13378 T13379 auxpass was,detected
R10566 T13379 T13379 ROOT detected,detected
R10567 T13380 T13379 prep in,detected
R10568 T13381 T13382 compound blood,vessels
R10569 T13382 T13380 pobj vessels,in
R10570 T13383 T13380 cc and,in
R10571 T13384 T13380 conj in,in
R10572 T13385 T13387 amod astrocytic,end-feet
R10573 T13386 T13387 amod perivascular,end-feet
R10574 T13387 T13384 pobj end-feet,in
R10575 T13388 T13379 punct ",",detected
R10576 T13389 T13379 cc and,detected
R10577 T13390 T13379 conj was,detected
R10578 T13391 T13390 acomp down-regulated,was
R10579 T13392 T13393 nummod 12,hrs
R10580 T13393 T13391 npadvmod hrs,down-regulated
R10581 T13394 T13390 prep after,was
R10582 T13395 T13396 nsubj SE,prior
R10583 T13396 T13390 advmod prior,was
R10584 T13397 T13396 prep to,prior
R10585 T13398 T13399 det the,appearance
R10586 T13399 T13397 pobj appearance,to
R10587 T13400 T13399 prep of,appearance
R10588 T13401 T13402 amod vasogenic,edema
R10589 T13402 T13400 pobj edema,of
R10590 T13403 T13402 cc and,edema
R10591 T13404 T13402 conj down-regulation,edema
R10592 T13405 T13402 prep of,edema
R10593 T13406 T13407 compound SMI-71,immunoreactivity
R10594 T13407 T13405 pobj immunoreactivity,of
R10595 T13408 T13379 punct .,detected
R10596 T13409 T13421 prep With,be
R10597 T13410 T13409 pobj respect,With
R10598 T13411 T13410 prep to,respect
R10599 T13412 T13414 det this,report
R10600 T13413 T13414 amod previous,report
R10601 T13414 T13411 pobj report,to
R10602 T13415 T13421 punct ",",be
R10603 T13416 T13421 nsubj changes,be
R10604 T13417 T13416 prep in,changes
R10605 T13418 T13419 compound SMI,immunoreactivity
R10606 T13419 T13417 pobj immunoreactivity,in
R10607 T13420 T13421 aux would,be
R10608 T13421 T13421 ROOT be,be
R10609 T13422 T13421 attr causes/results,be
R10610 T13423 T13422 prep of,causes/results
R10611 T13424 T13423 pobj interaction,of
R10612 T13425 T13424 prep between,interaction
R10613 T13426 T13427 amod endothelial,cells
R10614 T13427 T13425 pobj cells,between
R10615 T13428 T13427 cc and,cells
R10616 T13429 T13430 amod perivascular,astrocytes
R10617 T13430 T13427 conj astrocytes,cells
R10618 T13431 T13421 punct .,be
R10619 T13432 T13447 prep In,observed
R10620 T13433 T13435 det the,study
R10621 T13434 T13435 amod present,study
R10622 T13435 T13432 pobj study,In
R10623 T13436 T13447 punct ",",observed
R10624 T13437 T13447 nsubjpass p65-Ser276,observed
R10625 T13438 T13437 punct ",",p65-Ser276
R10626 T13439 T13437 conj p65-Ser311,p65-Ser276
R10627 T13440 T13439 punct ",",p65-Ser311
R10628 T13441 T13439 conj p65-Ser529,p65-Ser311
R10629 T13442 T13441 punct ",",p65-Ser529
R10630 T13443 T13441 cc and,p65-Ser529
R10631 T13444 T13445 compound p65-Ser536,phosphorylation
R10632 T13445 T13441 conj phosphorylation,p65-Ser529
R10633 T13446 T13447 auxpass was,observed
R10634 T13447 T13447 ROOT observed,observed
R10635 T13448 T13447 prep in,observed
R10636 T13449 T13448 pobj astrocytes,in
R10637 T13450 T13449 prep following,astrocytes
R10638 T13451 T13450 dobj SE,following
R10639 T13452 T13447 punct .,observed
R10640 T13453 T13458 advmod Furthermore,inhibited
R10641 T13454 T13458 punct ",",inhibited
R10642 T13455 T13456 amod sTNFp55R,infusion
R10643 T13456 T13458 nsubj infusion,inhibited
R10644 T13457 T13458 advmod effectively,inhibited
R10645 T13458 T13458 ROOT inhibited,inhibited
R10646 T13459 T13458 dobj p65-Ser276,inhibited
R10647 T13460 T13459 cc and,p65-Ser276
R10648 T13461 T13459 conj p65-Ser311phosphorylation,p65-Ser276
R10649 T13462 T13458 prep in,inhibited
R10650 T13463 T13462 pobj astrocytes,in
R10651 T13464 T13463 prep following,astrocytes
R10652 T13465 T13464 pobj SE,following
R10653 T13466 T13458 punct .,inhibited
R10654 T13467 T13470 advmod Therefore,is
R10655 T13468 T13470 punct ",",is
R10656 T13469 T13470 nsubj it,is
R10657 T13470 T13470 ROOT is,is
R10658 T13471 T13470 acomp likely,is
R10659 T13472 T13480 mark that,involved
R10660 T13473 T13474 amod enhanced,p65-Ser276
R10661 T13474 T13480 nsubjpass p65-Ser276,involved
R10662 T13475 T13474 cc and,p65-Ser276
R10663 T13476 T13477 compound p65-Ser311,phosphorylation
R10664 T13477 T13474 conj phosphorylation,p65-Ser276
R10665 T13478 T13480 aux may,involved
R10666 T13479 T13480 auxpass be,involved
R10667 T13480 T13470 ccomp involved,is
R10668 T13481 T13480 prep in,involved
R10669 T13482 T13483 compound TNF-α-mediated,BBB
R10670 T13483 T13484 compound BBB,disruption
R10671 T13484 T13481 pobj disruption,in
R10672 T13485 T13470 punct .,is
R10673 T13486 T13492 advmod However,prevent
R10674 T13487 T13492 punct ",",prevent
R10675 T13488 T13489 amod sTNFp55R,infusion
R10676 T13489 T13492 nsubj infusion,prevent
R10677 T13490 T13492 aux could,prevent
R10678 T13491 T13492 neg not,prevent
R10679 T13492 T13492 ROOT prevent,prevent
R10680 T13493 T13492 dobj p65-Ser529,prevent
R10681 T13494 T13493 cc and,p65-Ser529
R10682 T13495 T13493 conj p65-Ser536,p65-Ser529
R10683 T13496 T13493 conj phosphorylations,p65-Ser529
R10684 T13497 T13496 prep from,phosphorylations
R10685 T13498 T13499 compound SE,insults
R10686 T13499 T13497 pobj insults,from
R10687 T13500 T13492 punct .,prevent
R10688 T13501 T13506 mark Since,phosphorylated
R10689 T13502 T13505 nsubj p65-Ser529,are
R10690 T13503 T13502 cc and,p65-Ser529
R10691 T13504 T13502 conj p65-Ser536,p65-Ser529
R10692 T13505 T13506 auxpass are,phosphorylated
R10693 T13506 T13516 advcl phosphorylated,is
R10694 T13507 T13506 agent by,phosphorylated
R10695 T13508 T13507 pobj TNF-α,by
R10696 T13509 T13508 cc and,TNF-α
R10697 T13510 T13511 compound IL-1β,[
R10698 T13511 T13508 conj [,TNF-α
R10699 T13512 T13513 nummod 41,]
R10700 T13513 T13513 ROOT ],]
R10701 T13514 T13516 punct ",",is
R10702 T13515 T13516 nsubj it,is
R10703 T13516 T13516 ROOT is,is
R10704 T13517 T13516 acomp likely,is
R10705 T13518 T13526 mark that,play
R10706 T13519 T13523 amod IL-1β-mediated,phosphorylation
R10707 T13520 T13521 amod p65-Ser529,/
R10708 T13521 T13523 compound /,phosphorylation
R10709 T13522 T13523 compound Ser536,phosphorylation
R10710 T13523 T13526 nsubj phosphorylation,play
R10711 T13524 T13526 aux may,play
R10712 T13525 T13526 advmod also,play
R10713 T13526 T13517 ccomp play,likely
R10714 T13527 T13528 det a,role
R10715 T13528 T13526 dobj role,play
R10716 T13529 T13528 prep in,role
R10717 T13530 T13532 amod SE-induced,edema
R10718 T13531 T13532 amod vasogenic,edema
R10719 T13532 T13529 pobj edema,in
R10720 T13533 T13516 punct .,is
R10721 T13534 T13538 advmod Therefore,indicate
R10722 T13535 T13538 punct ",",indicate
R10723 T13536 T13537 poss our,findings
R10724 T13537 T13538 nsubj findings,indicate
R10725 T13538 T13563 nmod indicate,role
R10726 T13539 T13545 mark that,be
R10727 T13540 T13541 preconj both,TNF-α
R10728 T13541 T13545 nsubj TNF-α,be
R10729 T13542 T13541 cc and,TNF-α
R10730 T13543 T13541 conj IL-1β,TNF-α
R10731 T13544 T13545 aux may,be
R10732 T13545 T13538 ccomp be,indicate
R10733 T13546 T13545 attr synergists,be
R10734 T13547 T13548 aux to,play
R10735 T13548 T13545 xcomp play,be
R10736 T13549 T13553 preconj either,by
R10737 T13550 T13553 det a,by
R10738 T13551 T13553 amod direct,by
R10739 T13552 T13553 punct (,by
R10740 T13553 T13548 prep by,play
R10741 T13554 T13555 amod endothelial,cells
R10742 T13555 T13553 pobj cells,by
R10743 T13556 T13538 punct ),indicate
R10744 T13557 T13538 cc or,indicate
R10745 T13558 T13538 conj indirect,indicate
R10746 T13559 T13560 punct (,by
R10747 T13560 T13558 prep by,indirect
R10748 T13561 T13560 pobj astrocytes,by
R10749 T13562 T13563 punct ),role
R10750 T13563 T13563 ROOT role,role
R10751 T13564 T13563 prep in,role
R10752 T13565 T13566 det the,maintenance
R10753 T13566 T13564 pobj maintenance,in
R10754 T13567 T13566 prep of,maintenance
R10755 T13568 T13569 compound BBB,permeability
R10756 T13569 T13567 pobj permeability,of
R10757 T13570 T13563 punct .,role
R10758 T13571 T13572 compound Neutrophil,infiltration
R10759 T13572 T13578 nsubjpass infiltration,observed
R10760 T13573 T13572 prep into,infiltration
R10761 T13574 T13575 compound brain,parenchyma
R10762 T13575 T13573 pobj parenchyma,into
R10763 T13576 T13578 auxpass is,observed
R10764 T13577 T13578 advmod transiently,observed
R10765 T13578 T13578 ROOT observed,observed
R10766 T13579 T13578 prep during,observed
R10767 T13580 T13582 det the,phase
R10768 T13581 T13582 amod acute,phase
R10769 T13582 T13579 pobj phase,during
R10770 T13583 T13582 prep of,phase
R10771 T13584 T13583 pobj SE,of
R10772 T13585 T13586 punct (,4
R10773 T13586 T13588 meta 4,36
R10774 T13587 T13588 punct -,36
R10775 T13588 T13589 nummod 36,hr
R10776 T13589 T13582 appos hr,phase
R10777 T13590 T13589 prep after,hr
R10778 T13591 T13590 pobj SE,after
R10779 T13592 T13582 punct ),phase
R10780 T13593 T13578 cc and,observed
R10781 T13594 T13578 conj disappears,observed
R10782 T13595 T13596 advmod thereafter,[
R10783 T13596 T13598 amod [,]
R10784 T13597 T13598 nummod 20,]
R10785 T13598 T13594 dobj ],disappears
R10786 T13599 T13578 punct .,observed
R10787 T13600 T13602 nsubj SE,increases
R10788 T13601 T13602 advmod rapidly,increases
R10789 T13602 T13602 ROOT increases,increases
R10790 T13603 T13602 dobj synthesis,increases
R10791 T13604 T13603 cc and,synthesis
R10792 T13605 T13603 conj release,synthesis
R10793 T13606 T13605 prep of,release
R10794 T13607 T13606 pobj chemokines,of
R10795 T13608 T13607 prep in,chemokines
R10796 T13609 T13610 amod various,areas
R10797 T13610 T13608 pobj areas,in
R10798 T13611 T13610 prep of,areas
R10799 T13612 T13614 det the,brain
R10800 T13613 T13614 compound rodent,brain
R10801 T13614 T13611 pobj brain,of
R10802 T13615 T13617 nmod [,]
R10803 T13616 T13617 nummod 42,]
R10804 T13617 T13605 nmod ],release
R10805 T13618 T13602 punct .,increases
R10806 T13619 T13624 prep Among,required
R10807 T13620 T13619 pobj them,Among
R10808 T13621 T13624 punct ",",required
R10809 T13622 T13624 nsubjpass MIP-2,required
R10810 T13623 T13624 auxpass is,required
R10811 T13624 T13624 ROOT required,required
R10812 T13625 T13624 prep for,required
R10813 T13626 T13627 amod efficient,neutrophil
R10814 T13627 T13625 pobj neutrophil,for
R10815 T13628 T13627 cc or,neutrophil
R10816 T13629 T13630 compound lymphocyte,recruitment
R10817 T13630 T13627 conj recruitment,neutrophil
R10818 T13631 T13627 prep to,neutrophil
R10819 T13632 T13631 pobj brain,to
R10820 T13633 T13634 compound parenchyma,[
R10821 T13634 T13624 dobj [,required
R10822 T13635 T13636 nummod 43,]
R10823 T13636 T13634 appos ],[
R10824 T13637 T13624 punct .,required
R10825 T13638 T13653 prep In,regulated
R10826 T13639 T13641 poss our,study
R10827 T13640 T13641 amod previous,study
R10828 T13641 T13638 pobj study,In
R10829 T13642 T13644 nmod [,]
R10830 T13643 T13644 nummod 20,]
R10831 T13644 T13647 nmod ],infiltration
R10832 T13645 T13647 punct ",",infiltration
R10833 T13646 T13647 compound neutrophil,infiltration
R10834 T13647 T13653 nsubjpass infiltration,regulated
R10835 T13648 T13647 prep in,infiltration
R10836 T13649 T13651 det the,cortex
R10837 T13650 T13651 amod frontoparietal,cortex
R10838 T13651 T13648 pobj cortex,in
R10839 T13652 T13653 auxpass was,regulated
R10840 T13653 T13653 ROOT regulated,regulated
R10841 T13654 T13653 agent by,regulated
R10842 T13655 T13654 pobj P2X7,by
R10843 T13656 T13658 amod receptor-mediated,expression
R10844 T13657 T13658 compound MIP-2,expression
R10845 T13658 T13653 npadvmod expression,regulated
R10846 T13659 T13653 punct .,regulated
R10847 T13660 T13681 prep In,affect
R10848 T13661 T13662 det the,PC
R10849 T13662 T13660 pobj PC,In
R10850 T13663 T13681 punct ",",affect
R10851 T13664 T13681 advmod however,affect
R10852 T13665 T13681 punct ",",affect
R10853 T13666 T13678 preconj neither,infusion
R10854 T13667 T13678 det a,infusion
R10855 T13668 T13670 amod P2X7,agonist/antagonist
R10856 T13669 T13670 compound receptor,agonist/antagonist
R10857 T13670 T13678 amod agonist/antagonist,infusion
R10858 T13671 T13670 cc nor,agonist/antagonist
R10859 T13672 T13670 conj IL-1Ra,agonist/antagonist
R10860 T13673 T13672 punct (,IL-1Ra
R10861 T13674 T13676 det an,antagonist
R10862 T13675 T13676 compound IL-1β,antagonist
R10863 T13676 T13672 appos antagonist,IL-1Ra
R10864 T13677 T13672 punct ),IL-1Ra
R10865 T13678 T13681 nsubj infusion,affect
R10866 T13679 T13681 aux could,affect
R10867 T13680 T13681 neg not,affect
R10868 T13681 T13681 ROOT affect,affect
R10869 T13682 T13683 amod leukocyte,infiltration
R10870 T13683 T13681 dobj infiltration,affect
R10871 T13684 T13681 punct .,affect
R10872 T13685 T13693 prep In,inhibited
R10873 T13686 T13688 det the,study
R10874 T13687 T13688 amod present,study
R10875 T13688 T13685 pobj study,In
R10876 T13689 T13693 punct ",",inhibited
R10877 T13690 T13691 amod sTNFp55R,infusion
R10878 T13691 T13693 nsubj infusion,inhibited
R10879 T13692 T13693 advmod effectively,inhibited
R10880 T13693 T13693 ROOT inhibited,inhibited
R10881 T13694 T13695 compound neutrophil,infiltration
R10882 T13695 T13693 dobj infiltration,inhibited
R10883 T13696 T13695 prep in,infiltration
R10884 T13697 T13698 det the,PC
R10885 T13698 T13696 pobj PC,in
R10886 T13699 T13693 prep by,inhibited
R10887 T13700 T13699 pcomp reducing,by
R10888 T13701 T13703 amod vasogenic,formation
R10889 T13702 T13703 compound edema,formation
R10890 T13703 T13700 dobj formation,reducing
R10891 T13704 T13700 prep in,reducing
R10892 T13705 T13707 det a,manner
R10893 T13706 T13707 amod MIP-2-independent,manner
R10894 T13707 T13704 pobj manner,in
R10895 T13708 T13693 punct .,inhibited
R10896 T13709 T13720 prep With,is
R10897 T13710 T13709 pobj respect,With
R10898 T13711 T13710 prep to,respect
R10899 T13712 T13713 det the,present
R10900 T13713 T13711 pobj present,to
R10901 T13714 T13713 cc and,present
R10902 T13715 T13717 poss our,reports
R10903 T13716 T13717 amod previous,reports
R10904 T13717 T13713 conj reports,present
R10905 T13718 T13720 punct ",",is
R10906 T13719 T13720 nsubj it,is
R10907 T13720 T13720 ROOT is,is
R10908 T13721 T13722 advmod therefore,likely
R10909 T13722 T13720 acomp likely,is
R10910 T13723 T13730 mark that,induce
R10911 T13724 T13725 amod vasogenic,edema
R10912 T13725 T13730 nsubj edema,induce
R10913 T13726 T13725 acl induced,edema
R10914 T13727 T13726 agent by,induced
R10915 T13728 T13727 pobj TNF-α,by
R10916 T13729 T13730 aux can,induce
R10917 T13730 T13722 ccomp induce,likely
R10918 T13731 T13732 compound neutrophil,infiltration
R10919 T13732 T13730 dobj infiltration,induce
R10920 T13733 T13732 cc and,infiltration
R10921 T13734 T13735 compound press,injury
R10922 T13735 T13732 conj injury,infiltration
R10923 T13736 T13737 aux to,evoke
R10924 T13737 T13730 xcomp evoke,induce
R10925 T13738 T13739 amod neuronal-astroglial,loss
R10926 T13739 T13737 dobj loss,evoke
R10927 T13740 T13737 prep in,evoke
R10928 T13741 T13742 det the,PC
R10929 T13742 T13740 pobj PC,in
R10930 T13743 T13737 punct ",",evoke
R10931 T13744 T13730 prep unlike,induce
R10932 T13764 T13767 amod p65-Thr,phosphorylation
R10933 T13745 T13747 amod other,regions
R10934 T13765 T13767 nummod 435,phosphorylation
R10935 T13746 T13747 compound brain,regions
R10936 T13766 T13767 amod NF-κB,phosphorylation
R10937 T13767 T13770 nsubjpass phosphorylation,involved
R10938 T13747 T13744 pobj regions,unlike
R10939 T13768 T13770 aux may,involved
R10940 T13769 T13770 auxpass be,involved
R10941 T13748 T13720 punct .,is
R10942 T13770 T13754 ccomp involved,reveal
R10943 T13771 T13770 prep in,involved
R10944 T13772 T13774 amod SE-induced,edema
R10945 T13749 T13754 prep In,reveal
R10946 T13773 T13774 amod vasogenic,edema
R10947 T13774 T13771 pobj edema,in
R10948 T13775 T13774 punct ",",edema
R10949 T13750 T13749 pobj conclusion,In
R10950 T13776 T13777 nsubj which,is
R10951 T13777 T13774 relcl is,edema
R10952 T13751 T13754 punct ",",reveal
R10953 T13778 T13777 acomp relevant,is
R10954 T13779 T13780 aux to,neutrophil
R10955 T13752 T13753 poss our,findings
R10956 T13780 T13781 amod neutrophil,infiltration
R10957 T13781 T13777 attr infiltration,is
R10958 T13782 T13781 cc and,infiltration
R10959 T13783 T13784 amod neuronal-astroglial,loss
R10960 T13784 T13781 conj loss,infiltration
R10961 T13785 T13754 punct .,reveal
R10962 T13753 T13754 nsubj findings,reveal
R10963 T13754 T13754 ROOT reveal,reveal
R10964 T13755 T13763 mark that,mediated
R10965 T13756 T13763 nsubj impairments,mediated
R10966 T13757 T13756 prep of,impairments
R10967 T13758 T13760 amod endothelial,function
R10968 T13759 T13760 compound cell,function
R10969 T13760 T13757 pobj function,of
R10970 T13761 T13756 prep via,impairments
R10971 T13762 T13763 nsubj TNF-α,mediated
R10972 T13763 T13770 advcl mediated,involved