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PMC:3218875 JSONTXT 30 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T114 0-8 JJ denotes Negative
T115 9-19 NN denotes regulation
T116 20-22 IN denotes of
T117 23-28 NNP denotes NF-κB
T118 29-32 CC denotes and
T119 33-36 PRP$ denotes its
T120 37-48 NN denotes involvement
T121 49-51 IN denotes in
T122 52-62 JJ denotes rheumatoid
T123 63-72 NNS denotes arthritis
T124 83-86 DT denotes The
T125 87-100 NN denotes transcription
T126 101-107 NN denotes factor
T127 108-113 NNP denotes NF-κB
T128 114-119 VBZ denotes plays
T129 120-127 JJ denotes crucial
T130 128-133 NNS denotes roles
T131 134-136 IN denotes in
T132 137-140 DT denotes the
T133 141-151 NN denotes regulation
T134 152-154 IN denotes of
T135 155-167 NN denotes inflammation
T136 168-171 CC denotes and
T137 172-177 NN denotes mmune
T138 178-187 NNS denotes responses
T139 187-188 , denotes ,
T140 189-192 CC denotes and
T141 193-206 JJ denotes inappropriate
T142 207-212 NN denotes NF-κB
T143 213-221 NN denotes activity
T144 222-225 VBZ denotes has
T145 226-230 VBN denotes been
T146 231-237 VBN denotes linked
T147 238-242 IN denotes with
T148 243-247 JJ denotes many
T149 248-258 JJ denotes autoimmune
T150 259-262 CC denotes and
T151 263-275 JJ denotes inflammatory
T152 276-284 NNS denotes diseases
T153 284-285 , denotes ,
T154 286-295 VBG denotes including
T155 296-306 JJ denotes rheumatoid
T156 307-316 NNS denotes arthritis
T157 316-317 . denotes .
T158 318-323 NNS denotes Cells
T159 324-330 VBP denotes employ
T160 331-332 DT denotes a
T161 333-345 JJ denotes multilayered
T162 346-353 NN denotes control
T163 354-360 NN denotes system
T164 361-363 TO denotes to
T165 364-368 VB denotes keep
T166 369-374 JJ denotes NF-κB
T167 375-385 NN denotes signalling
T168 386-388 IN denotes in
T169 389-394 NN denotes check
T170 394-395 , denotes ,
T171 396-405 VBG denotes including
T172 406-407 DT denotes a
T173 408-418 NN denotes repertoire
T174 419-421 IN denotes of
T175 422-430 JJ denotes negative
T176 431-439 NN denotes feedback
T177 440-450 NNS denotes regulators
T178 451-459 VBG denotes ensuring
T179 460-471 NN denotes termination
T180 472-474 IN denotes of
T181 475-480 JJ denotes NF-κB
T182 481-490 NNS denotes responses
T183 490-491 . denotes .
T184 492-496 RB denotes Here
T185 497-499 PRP denotes we
T186 500-504 MD denotes will
T187 505-511 VB denotes review
T188 512-519 JJ denotes various
T189 520-528 JJ denotes negative
T190 529-539 JJ denotes regulatory
T191 540-550 NNS denotes mechanisms
T192 551-555 WDT denotes that
T193 556-560 VBP denotes have
T194 561-568 VBN denotes evolved
T195 569-571 TO denotes to
T196 572-579 VB denotes control
T197 580-585 JJ denotes NF-κB
T198 586-596 NN denotes signalling
T199 597-600 CC denotes and
T200 601-606 WDT denotes which
T201 607-611 VBP denotes have
T202 612-616 VBN denotes been
T203 617-627 VBN denotes implicated
T204 628-630 IN denotes in
T205 631-634 DT denotes the
T206 635-647 NN denotes pathogenesis
T207 648-650 IN denotes of
T208 651-661 JJ denotes rheumatoid
T209 662-671 NNS denotes arthritis
T210 671-672 . denotes .
T832 687-697 JJ denotes Rheumatoid
T833 698-707 NNS denotes arthritis
T834 708-709 -LRB- denotes (
T835 709-711 NNP denotes RA
T836 711-712 -RRB- denotes )
T837 713-715 VBZ denotes is
T838 716-719 DT denotes the
T839 720-724 RBS denotes most
T840 725-731 JJ denotes common
T841 732-744 JJ denotes inflammatory
T842 745-754 NNS denotes arthritis
T843 754-755 , denotes ,
T844 756-765 VBG denotes affecting
T845 766-768 RP denotes up
T846 769-771 TO denotes to
T847 772-773 CD denotes 1
T848 773-774 NN denotes %
T849 775-777 IN denotes of
T850 778-781 DT denotes the
T851 782-787 NN denotes adult
T852 788-798 NN denotes population
T853 798-799 . denotes .
T854 800-802 NNP denotes RA
T855 803-805 VBZ denotes is
T856 806-819 VBN denotes characterised
T857 820-822 IN denotes by
T858 823-824 DT denotes a
T859 825-836 JJ denotes symmetrical
T860 837-850 NN denotes polyarthritis
T861 851-853 IN denotes in
T862 854-859 WDT denotes which
T863 860-867 JJ denotes chronic
T864 868-880 NN denotes inflammation
T865 881-883 IN denotes of
T866 884-890 NNS denotes joints
T867 891-893 VBZ denotes is
T868 894-904 VBN denotes associated
T869 905-909 IN denotes with
T870 910-911 DT denotes a
T871 912-923 JJ denotes progressive
T872 924-935 NN denotes destruction
T873 936-938 IN denotes of
T874 939-948 NN denotes cartilage
T875 949-952 CC denotes and
T876 953-957 NN denotes bone
T877 957-958 , denotes ,
T878 959-966 VBG denotes leading
T879 967-969 TO denotes to
T880 970-980 JJ denotes functional
T881 981-988 NN denotes decline
T882 989-992 CC denotes and
T883 993-1003 NN denotes disability
T884 1003-1004 . denotes .
T885 1005-1017 NNP denotes Infiltration
T886 1018-1020 IN denotes of
T887 1021-1026 NNS denotes cells
T888 1027-1029 IN denotes of
T889 1030-1033 DT denotes the
T890 1034-1040 NN denotes innate
T891 1041-1044 CC denotes and
T892 1045-1053 JJ denotes adaptive
T893 1054-1060 JJ denotes immune
T894 1061-1067 NN denotes system
T895 1068-1072 IN denotes into
T896 1073-1076 DT denotes the
T897 1077-1082 JJ denotes joint
T898 1083-1088 NN denotes space
T899 1089-1095 VBZ denotes drives
T900 1096-1099 DT denotes the
T901 1100-1105 JJ denotes local
T902 1106-1116 NN denotes production
T903 1117-1119 IN denotes of
T904 1120-1135 JJ denotes proinflammatory
T905 1136-1144 NN denotes T-helper
T906 1145-1149 NN denotes type
T907 1150-1151 CD denotes 1
T908 1152-1155 CC denotes and
T909 1156-1164 NNP denotes T-helper
T910 1165-1169 NN denotes type
T911 1170-1172 CD denotes 17
T912 1173-1182 NNS denotes cytokines
T913 1182-1183 , denotes ,
T914 1184-1194 NNS denotes chemokines
T915 1194-1195 , denotes ,
T916 1196-1199 CC denotes and
T917 1200-1206 NN denotes matrix
T918 1207-1225 NNS denotes metalloproteinases
T919 1226-1228 IN denotes by
T920 1229-1241 VBG denotes infiltrating
T921 1242-1251 NNS denotes monocytes
T922 1252-1255 CC denotes and
T923 1256-1264 JJ denotes synovial
T924 1265-1270 NNS denotes cells
T925 1270-1271 . denotes .
T926 1272-1285 NNP denotes Proliferation
T927 1286-1288 IN denotes of
T928 1289-1297 JJ denotes synovial
T929 1298-1309 NNS denotes fibroblasts
T930 1310-1315 VBZ denotes leads
T931 1316-1318 TO denotes to
T932 1319-1322 DT denotes the
T933 1323-1332 NN denotes formation
T934 1333-1335 IN denotes of
T935 1336-1342 NN denotes pannus
T936 1343-1349 NN denotes tissue
T937 1349-1350 , denotes ,
T938 1351-1356 WDT denotes which
T939 1357-1364 VBZ denotes invades
T940 1365-1368 CC denotes and
T941 1369-1377 VBZ denotes degrades
T942 1378-1387 JJ denotes articular
T943 1388-1397 NN denotes cartilage
T944 1398-1401 CC denotes and
T945 1402-1413 JJ denotes subchondral
T946 1414-1418 NN denotes bone
T947 1418-1419 . denotes .
T948 1420-1423 DT denotes The
T949 1424-1433 NN denotes aetiology
T950 1434-1436 IN denotes of
T951 1437-1439 NNP denotes RA
T952 1440-1442 VBZ denotes is
T953 1443-1448 RB denotes still
T954 1449-1452 RB denotes not
T955 1453-1463 VBN denotes understood
T956 1463-1464 , denotes ,
T957 1465-1468 CC denotes but
T958 1469-1471 PRP denotes it
T959 1472-1474 VBZ denotes is
T960 1475-1479 RB denotes well
T961 1480-1488 VBN denotes accepted
T962 1489-1493 IN denotes that
T963 1494-1504 NN denotes activation
T964 1505-1507 IN denotes of
T965 1508-1523 JJ denotes NF-κB-dependent
T966 1524-1528 NN denotes gene
T967 1529-1539 NN denotes expression
T968 1540-1545 VBZ denotes plays
T969 1546-1547 DT denotes a
T970 1548-1551 JJ denotes key
T971 1552-1556 NN denotes role
T972 1557-1559 IN denotes in
T973 1560-1563 DT denotes the
T974 1564-1575 NN denotes development
T975 1576-1578 IN denotes of
T976 1579-1581 NNP denotes RA
T977 1582-1585 CC denotes and
T978 1586-1590 JJ denotes many
T979 1591-1596 JJ denotes other
T980 1597-1607 JJ denotes autoimmune
T981 1608-1616 NNS denotes diseases
T982 1616-1617 . denotes .
T983 1618-1623 NN denotes NF-κB
T984 1624-1634 VBZ denotes represents
T985 1635-1636 DT denotes a
T986 1637-1643 NN denotes family
T987 1644-1646 IN denotes of
T988 1647-1659 RB denotes structurally
T989 1660-1667 VBN denotes related
T990 1668-1671 CC denotes and
T991 1672-1686 RB denotes evolutionarily
T992 1687-1696 VBD denotes conserved
T993 1697-1705 NNS denotes proteins
T994 1706-1707 -LRB- denotes (
T995 1707-1711 CD denotes p100
T996 1712-1714 CC denotes or
T997 1715-1721 NNP denotes NF-κB2
T998 1721-1722 , denotes ,
T999 1723-1727 CD denotes p105
T1000 1728-1730 CC denotes or
T1001 1731-1737 NNP denotes NF-κB1
T1002 1737-1738 , denotes ,
T1003 1739-1742 CD denotes p65
T1004 1743-1745 CC denotes or
T1005 1746-1750 NNP denotes RelA
T1006 1750-1751 , denotes ,
T1007 1752-1756 NNP denotes RelB
T1008 1756-1757 , denotes ,
T1009 1758-1763 NNP denotes c-Rel
T1010 1763-1764 -RRB- denotes )
T1011 1765-1769 WDT denotes that
T1012 1770-1778 VBP denotes function
T1013 1779-1781 IN denotes as
T1014 1782-1792 NNS denotes homodimers
T1015 1793-1795 CC denotes or
T1016 1796-1808 NNS denotes heterodimers
T1017 1809-1810 VBP denotes [
T1018 1810-1811 CD denotes 1
T1019 1811-1812 NNP denotes ]
T1020 1812-1813 , denotes ,
T1021 1814-1817 CC denotes and
T1022 1818-1822 IN denotes that
T1023 1823-1831 VB denotes regulate
T1024 1832-1835 DT denotes the
T1025 1836-1846 NN denotes expression
T1026 1847-1849 IN denotes of
T1027 1850-1851 DT denotes a
T1028 1852-1857 JJ denotes large
T1029 1858-1864 NN denotes number
T1030 1865-1867 IN denotes of
T1031 1868-1873 NNS denotes genes
T1032 1874-1875 : denotes -
T1033 1876-1880 JJ denotes such
T1034 1881-1883 IN denotes as
T1035 1884-1887 NNP denotes TNF
T1036 1887-1888 , denotes ,
T1037 1889-1893 NNP denotes IL-1
T1038 1893-1894 , denotes ,
T1039 1895-1899 NNP denotes IL-6
T1040 1899-1900 , denotes ,
T1041 1901-1918 JJ denotes cyclo-oxygenase-2
T1042 1918-1919 , denotes ,
T1043 1920-1930 NNS denotes chemokines
T1044 1930-1931 , denotes ,
T1045 1932-1941 JJ denotes inducible
T1046 1942-1948 JJ denotes nitric
T1047 1949-1954 NN denotes oxide
T1048 1955-1963 NN denotes synthase
T1049 1963-1964 , denotes ,
T1050 1965-1968 CC denotes and
T1051 1969-1975 NN denotes matrix
T1052 1976-1994 NNS denotes metalloproteinases
T1053 1995-1996 : denotes -
T1054 1997-2001 WDT denotes that
T1055 2002-2005 VBP denotes are
T1056 2006-2014 VBN denotes involved
T1057 2015-2017 IN denotes in
T1058 2018-2020 NNP denotes RA
T1059 2020-2021 . denotes .
T1060 2022-2024 IN denotes In
T1061 2025-2033 NN denotes addition
T1062 2033-2034 , denotes ,
T1063 2035-2038 NNP denotes TNF
T1064 2039-2042 CC denotes and
T1065 2043-2047 NNP denotes IL-1
T1066 2048-2051 VBP denotes are
T1067 2052-2062 PRP denotes themselves
T1068 2063-2067 RB denotes very
T1069 2068-2074 JJ denotes potent
T1070 2075-2085 NNS denotes activators
T1071 2086-2088 IN denotes of
T1072 2089-2094 NNP denotes NF-κB
T1073 2095-2096 -LRB- denotes (
T1074 2096-2104 VBN denotes reviewed
T1075 2105-2107 IN denotes in
T1076 2108-2109 NNP denotes [
T1077 2109-2112 CD denotes 2,3
T1078 2112-2113 NNP denotes ]
T1079 2113-2114 -RRB- denotes )
T1080 2114-2115 . denotes .
T1081 2116-2121 JJ denotes NF-κB
T1082 2122-2132 NN denotes activation
T1083 2133-2136 MD denotes can
T1084 2137-2139 VB denotes be
T1085 2140-2148 VBN denotes detected
T1086 2149-2151 IN denotes in
T1087 2152-2160 JJ denotes cultured
T1088 2161-2169 JJ denotes synovial
T1089 2170-2181 NNS denotes fibroblasts
T1090 2182-2185 CC denotes and
T1091 2186-2194 JJ denotes synovial
T1092 2195-2201 NN denotes tissue
T1093 2202-2206 IN denotes from
T1094 2207-2209 NNP denotes RA
T1095 2210-2218 NNS denotes patients
T1096 2218-2219 , denotes ,
T1097 2220-2223 CC denotes and
T1098 2224-2230 NN denotes animal
T1099 2231-2237 NNS denotes models
T1100 2238-2240 IN denotes of
T1101 2241-2253 JJ denotes inflammatory
T1102 2254-2263 NNS denotes arthritis
T1103 2264-2268 RB denotes also
T1104 2269-2280 VBP denotes demonstrate
T1105 2281-2284 DT denotes the
T1106 2285-2291 JJ denotes active
T1107 2292-2296 NN denotes role
T1108 2297-2299 IN denotes of
T1109 2300-2305 NN denotes NF-κB
T1110 2306-2308 IN denotes in
T1111 2309-2312 DT denotes the
T1112 2313-2324 NN denotes development
T1113 2325-2328 CC denotes and
T1114 2329-2340 NN denotes progression
T1115 2341-2343 IN denotes of
T1116 2344-2346 NNP denotes RA
T1117 2347-2348 -LRB- denotes (
T1118 2348-2356 VBN denotes reviewed
T1119 2357-2359 IN denotes in
T1120 2360-2361 NNP denotes [
T1121 2361-2362 CD denotes 4
T1122 2362-2363 NNP denotes ]
T1123 2363-2364 -RRB- denotes )
T1124 2364-2365 . denotes .
T1125 2366-2369 DT denotes The
T1126 2370-2374 NN denotes time
T1127 2375-2381 NN denotes course
T1128 2382-2384 IN denotes of
T1129 2385-2390 JJ denotes NF-κB
T1130 2391-2401 NN denotes activation
T1131 2402-2409 VBZ denotes appears
T1132 2410-2412 TO denotes to
T1133 2413-2420 VB denotes precede
T1134 2421-2424 DT denotes the
T1135 2425-2430 NN denotes onset
T1136 2431-2433 IN denotes of
T1137 2434-2441 NN denotes disease
T1138 2441-2442 , denotes ,
T1139 2443-2446 CC denotes and
T1140 2447-2455 NN denotes blockade
T1141 2456-2458 IN denotes of
T1142 2459-2464 NN denotes NF-κB
T1143 2465-2467 IN denotes by
T1144 2468-2477 JJ denotes different
T1145 2478-2483 NNS denotes means
T1146 2484-2493 VBZ denotes decreases
T1147 2494-2501 NN denotes disease
T1148 2502-2510 NN denotes severity
T1149 2511-2512 NNP denotes [
T1150 2512-2515 CD denotes 5,6
T1151 2515-2516 NNP denotes ]
T1152 2516-2517 . denotes .
T1153 2518-2522 JJ denotes Next
T1154 2523-2525 TO denotes to
T1155 2526-2529 PRP$ denotes its
T1156 2530-2534 NN denotes role
T1157 2535-2537 IN denotes in
T1158 2538-2553 JJ denotes proinflammatory
T1159 2554-2558 NN denotes gene
T1160 2559-2569 NN denotes expression
T1161 2569-2570 , denotes ,
T1162 2571-2576 NNP denotes NF-κB
T1163 2577-2579 VBZ denotes is
T1164 2580-2584 RB denotes also
T1165 2585-2594 JJ denotes essential
T1166 2595-2598 IN denotes for
T1167 2599-2617 NN denotes osteoclastogenesis
T1168 2617-2618 , denotes ,
T1169 2619-2625 RB denotes mainly
T1170 2626-2628 IN denotes by
T1171 2629-2638 VBG denotes mediating
T1172 2639-2642 DT denotes the
T1173 2643-2650 NNS denotes effects
T1174 2651-2653 IN denotes of
T1175 2654-2662 NN denotes receptor
T1176 2663-2672 NN denotes activator
T1177 2673-2675 IN denotes of
T1178 2676-2681 JJ denotes NF-κB
T1179 2682-2688 NN denotes ligand
T1180 2689-2690 -LRB- denotes (
T1181 2690-2695 NNP denotes RANKL
T1182 2695-2696 -RRB- denotes )
T1183 2696-2697 . denotes .
T1184 2698-2705 NNS denotes Defects
T1185 2706-2708 IN denotes in
T1186 2709-2712 DT denotes the
T1187 2713-2723 NN denotes regulation
T1188 2724-2726 IN denotes of
T1189 2727-2745 NN denotes osteoclastogenesis
T1190 2746-2749 VBP denotes are
T1191 2750-2753 DT denotes the
T1192 2754-2759 JJ denotes major
T1193 2760-2765 NN denotes cause
T1194 2766-2768 IN denotes of
T1195 2769-2773 NN denotes bone
T1196 2774-2781 NN denotes erosion
T1197 2782-2784 IN denotes in
T1198 2785-2795 JJ denotes osteolytic
T1199 2796-2804 NNS denotes diseases
T1200 2805-2809 JJ denotes such
T1201 2810-2812 IN denotes as
T1202 2813-2815 NNP denotes RA
T1203 2816-2817 NNP denotes [
T1204 2817-2818 CD denotes 7
T1205 2818-2819 NNP denotes ]
T1206 2819-2820 . denotes .
T1207 2821-2828 RB denotes Finally
T1208 2828-2829 , denotes ,
T1209 2830-2836 JJ denotes recent
T1210 2837-2848 NNS denotes discoveries
T1211 2849-2858 VBG denotes revealing
T1212 2859-2860 DT denotes a
T1213 2861-2868 JJ denotes genetic
T1214 2869-2880 NN denotes association
T1215 2881-2885 IN denotes with
T1216 2886-2893 JJ denotes several
T1217 2894-2899 NNS denotes genes
T1218 2900-2908 JJ denotes relevant
T1219 2909-2911 TO denotes to
T1220 2912-2917 JJ denotes NF-κB
T1221 2918-2928 NN denotes signalling
T1222 2928-2929 , denotes ,
T1223 2930-2939 VBG denotes including
T1224 2940-2944 NNP denotes CD40
T1225 2944-2945 , denotes ,
T1226 2946-2951 CD denotes TRAF1
T1227 2951-2952 , denotes ,
T1228 2953-2960 CD denotes TNFAIP3
T1229 2960-2961 , denotes ,
T1230 2962-2965 CC denotes and
T1231 2966-2971 NNP denotes c-REL
T1232 2971-2972 , denotes ,
T1233 2973-2980 JJ denotes further
T1234 2981-2990 NN denotes highlight
T1235 2991-2994 DT denotes the
T1236 2995-3005 NN denotes importance
T1237 3006-3008 IN denotes of
T1238 3009-3014 JJ denotes NF-κB
T1239 3015-3025 NN denotes activation
T1240 3026-3028 IN denotes in
T1241 3029-3031 NNP denotes RA
T1242 3032-3044 NN denotes pathogenesis
T1243 3045-3046 NN denotes [
T1244 3046-3047 CD denotes 8
T1245 3047-3048 NNP denotes ]
T1246 3048-3049 . denotes .
T2608 3099-3104 IN denotes Since
T2609 3105-3110 NNP denotes NF-κB
T2610 3111-3113 VBZ denotes is
T2611 3114-3121 JJ denotes central
T2612 3122-3124 TO denotes to
T2613 3125-3128 DT denotes the
T2614 3129-3136 NN denotes process
T2615 3137-3139 IN denotes of
T2616 3140-3152 NN denotes inflammation
T2617 3153-3155 IN denotes in
T2618 3156-3158 NNP denotes RA
T2619 3158-3159 , denotes ,
T2620 3160-3164 JJ denotes much
T2621 3165-3173 NN denotes research
T2622 3174-3179 NNS denotes deals
T2623 3180-3184 IN denotes with
T2624 3185-3188 DT denotes the
T2625 3189-3203 NN denotes identification
T2626 3204-3206 IN denotes of
T2627 3207-3210 DT denotes the
T2628 3211-3220 JJ denotes molecular
T2629 3221-3229 VBZ denotes triggers
T2630 3230-3234 IN denotes that
T2631 3235-3243 VBP denotes activate
T2632 3244-3249 NN denotes NF-κB
T2633 3250-3252 IN denotes in
T2634 3253-3255 NNP denotes RA
T2635 3255-3256 . denotes .
T2636 3257-3259 PRP denotes It
T2637 3260-3262 VBZ denotes is
T2638 3263-3267 RB denotes well
T2639 3268-3276 VBN denotes accepted
T2640 3277-3281 IN denotes that
T2641 3282-3297 JJ denotes proinflammatory
T2642 3298-3307 NNS denotes cytokines
T2643 3308-3312 JJ denotes such
T2644 3313-3315 IN denotes as
T2645 3316-3319 NNP denotes TNF
T2646 3320-3323 CC denotes and
T2647 3324-3328 NNP denotes IL-1
T2648 3329-3333 VBP denotes play
T2649 3334-3336 DT denotes an
T2650 3337-3346 JJ denotes important
T2651 3347-3351 NN denotes role
T2652 3351-3352 , denotes ,
T2653 3353-3356 CC denotes and
T2654 3357-3371 NN denotes administration
T2655 3372-3374 IN denotes of
T2656 3375-3378 NNP denotes TNF
T2657 3379-3390 NNS denotes antagonists
T2658 3391-3393 VBZ denotes is
T2659 3394-3396 DT denotes an
T2660 3397-3406 JJ denotes effective
T2661 3407-3416 NN denotes treatment
T2662 3417-3420 IN denotes for
T2663 3421-3427 JJ denotes severe
T2664 3428-3430 NNP denotes RA
T2665 3431-3432 -LRB- denotes (
T2666 3432-3440 VBN denotes reviewed
T2667 3441-3443 IN denotes in
T2668 3444-3445 NNP denotes [
T2669 3445-3446 CD denotes 9
T2670 3446-3447 NNP denotes ]
T2671 3447-3448 -RRB- denotes )
T2672 3448-3449 . denotes .
T2673 3450-3453 NNP denotes TNF
T2674 3454-3457 CC denotes and
T2675 3458-3462 NNP denotes IL-1
T2676 3463-3466 VBP denotes are
T2677 3467-3471 DT denotes both
T2678 3472-3476 RB denotes very
T2679 3477-3483 JJ denotes potent
T2680 3484-3494 NNS denotes activators
T2681 3495-3497 IN denotes of
T2682 3498-3503 NN denotes NF-κB
T2683 3504-3507 CC denotes and
T2684 3508-3510 PRP denotes it
T2685 3511-3514 MD denotes can
T2686 3515-3517 VB denotes be
T2687 3518-3526 VBN denotes expected
T2688 3527-3531 DT denotes that
T2689 3532-3537 JJ denotes NF-κB
T2690 3538-3548 NN denotes activation
T2691 3549-3551 IN denotes by
T2692 3552-3557 DT denotes these
T2693 3558-3567 NNS denotes cytokines
T2694 3568-3576 VBZ denotes mediates
T2695 3577-3581 JJS denotes most
T2696 3582-3584 IN denotes of
T2697 3585-3590 PRP$ denotes their
T2698 3591-3607 JJ denotes pro-inflammatory
T2699 3608-3618 NNS denotes activities
T2700 3619-3621 IN denotes in
T2701 3622-3624 NNP denotes RA
T2702 3625-3626 -LRB- denotes (
T2703 3626-3634 VBN denotes reviewed
T2704 3635-3637 IN denotes in
T2705 3638-3639 NNP denotes [
T2706 3639-3640 CD denotes 3
T2707 3640-3641 NNP denotes ]
T2708 3641-3642 -RRB- denotes )
T2709 3642-3643 . denotes .
T2710 3644-3649 JJ denotes NF-κB
T2711 3650-3660 NN denotes activation
T2712 3661-3663 IN denotes by
T2713 3664-3672 NN denotes receptor
T2714 3673-3682 NN denotes activator
T2715 3683-3685 IN denotes of
T2716 3686-3691 NNP denotes NF-κB
T2717 3692-3693 -LRB- denotes (
T2718 3693-3697 NNP denotes RANK
T2719 3697-3698 -RRB- denotes )
T2720 3698-3699 , denotes ,
T2721 3700-3701 DT denotes a
T2722 3702-3705 NNP denotes TNF
T2723 3706-3714 NN denotes receptor
T2724 3715-3721 NN denotes family
T2725 3722-3728 NN denotes member
T2726 3728-3729 , denotes ,
T2727 3730-3732 VBZ denotes is
T2728 3733-3742 JJ denotes important
T2729 3743-3746 IN denotes for
T2730 3747-3765 NN denotes osteoclastogenesis
T2731 3765-3766 , denotes ,
T2732 3767-3770 CC denotes and
T2733 3771-3778 NNS denotes defects
T2734 3779-3781 IN denotes in
T2735 3782-3788 JJ denotes proper
T2736 3789-3799 NN denotes RANK-NF-κB
T2737 3800-3810 VBG denotes signalling
T2738 3811-3814 VBP denotes are
T2739 3815-3821 JJ denotes likely
T2740 3822-3824 TO denotes to
T2741 3825-3827 VB denotes be
T2742 3828-3836 VBN denotes involved
T2743 3837-3839 IN denotes in
T2744 3840-3842 NNP denotes RA
T2745 3843-3852 NN denotes pathology
T2746 3853-3856 CC denotes and
T2747 3857-3862 JJ denotes other
T2748 3863-3871 NNS denotes diseases
T2749 3872-3882 VBN denotes associated
T2750 3883-3887 IN denotes with
T2751 3888-3892 NN denotes bone
T2752 3893-3897 NN denotes loss
T2753 3898-3899 NN denotes [
T2754 3899-3900 CD denotes 7
T2755 3900-3901 NNP denotes ]
T2756 3901-3902 . denotes .
T2757 3903-3907 CD denotes CD40
T2758 3908-3910 VBZ denotes is
T2759 3911-3918 DT denotes another
T2760 3919-3922 NN denotes TNF
T2761 3923-3931 NN denotes receptor
T2762 3932-3938 NN denotes family
T2763 3939-3945 NN denotes member
T2764 3946-3950 WDT denotes that
T2765 3951-3953 VBZ denotes is
T2766 3954-3966 RB denotes functionally
T2767 3967-3976 VBN denotes expressed
T2768 3977-3979 IN denotes on
T2769 3980-3981 DT denotes a
T2770 3982-3989 NN denotes variety
T2771 3990-3992 IN denotes of
T2772 3993-3997 NN denotes cell
T2773 3998-4003 NNS denotes types
T2774 4003-4004 , denotes ,
T2775 4005-4014 VBG denotes including
T2776 4015-4021 JJ denotes smooth
T2777 4022-4028 NN denotes muscle
T2778 4029-4040 NNS denotes fibroblasts
T2779 4041-4045 IN denotes from
T2780 4046-4052 JJ denotes normal
T2781 4053-4056 CC denotes and
T2782 4057-4059 NNP denotes RA
T2783 4060-4068 NNS denotes patients
T2784 4069-4072 CC denotes and
T2785 4073-4075 NNP denotes RA
T2786 4076-4084 JJ denotes synovial
T2787 4085-4090 NNS denotes cells
T2788 4090-4091 , denotes ,
T2789 4092-4093 NNP denotes B
T2790 4094-4099 NNS denotes cells
T2791 4099-4100 , denotes ,
T2792 4101-4112 NNS denotes macrophages
T2793 4112-4113 , denotes ,
T2794 4114-4117 CC denotes and
T2795 4118-4127 JJ denotes dendritic
T2796 4128-4133 NNS denotes cells
T2797 4133-4134 , denotes ,
T2798 4135-4138 CC denotes and
T2799 4139-4142 MD denotes can
T2800 4143-4145 VB denotes be
T2801 4146-4157 VBN denotes upregulated
T2802 4158-4160 IN denotes by
T2803 4161-4176 JJ denotes proinflammatory
T2804 4177-4186 NNS denotes cytokines
T2805 4187-4196 VBG denotes including
T2806 4197-4200 NNP denotes TNF
T2807 4201-4202 NNP denotes [
T2808 4202-4204 CD denotes 10
T2809 4204-4205 NNP denotes ]
T2810 4205-4206 . denotes .
T2811 4207-4214 VBG denotes Binding
T2812 4215-4217 IN denotes of
T2813 4218-4221 DT denotes the
T2814 4222-4226 NNP denotes CD40
T2815 4227-4233 NN denotes ligand
T2816 4234-4235 -LRB- denotes (
T2817 4235-4240 NNP denotes CD154
T2818 4240-4241 -RRB- denotes )
T2819 4241-4242 , denotes ,
T2820 4243-4248 WDT denotes which
T2821 4249-4251 VBZ denotes is
T2822 4252-4263 RB denotes transiently
T2823 4264-4273 VBN denotes expressed
T2824 4274-4276 IN denotes on
T2825 4277-4280 DT denotes the
T2826 4281-4288 NN denotes surface
T2827 4289-4291 IN denotes of
T2828 4292-4301 VBN denotes activated
T2829 4302-4305 NNP denotes CD4
T2830 4305-4306 CD denotes +
T2831 4307-4308 NNP denotes T
T2832 4309-4314 NNS denotes cells
T2833 4314-4315 , denotes ,
T2834 4316-4324 VBZ denotes triggers
T2835 4325-4330 NNP denotes NF-κB
T2836 4331-4341 NN denotes activation
T2837 4342-4351 VBG denotes resulting
T2838 4352-4354 IN denotes in
T2839 4355-4365 NN denotes fibroblast
T2840 4366-4379 NN denotes proliferation
T2841 4380-4383 CC denotes and
T2842 4384-4393 NN denotes secretion
T2843 4394-4396 IN denotes of
T2844 4397-4412 JJ denotes proinflammatory
T2845 4413-4422 NNS denotes cytokines
T2846 4423-4426 CC denotes and
T2847 4427-4437 NNS denotes chemokines
T2848 4437-4438 , denotes ,
T2849 4439-4444 WDT denotes which
T2850 4445-4456 VBZ denotes contributes
T2851 4457-4459 TO denotes to
T2852 4460-4465 JJ denotes joint
T2853 4466-4477 NN denotes destruction
T2854 4477-4478 . denotes .
T2855 4479-4486 RB denotes However
T2856 4486-4487 , denotes ,
T2857 4488-4495 NNS denotes studies
T2858 4496-4500 IN denotes with
T2859 4501-4513 JJ denotes antagonistic
T2860 4514-4523 JJ denotes anti-CD40
T2861 4524-4526 CC denotes or
T2862 4527-4537 JJ denotes anti-CD154
T2863 4538-4548 NNS denotes antibodies
T2864 4549-4552 VBD denotes led
T2865 4553-4555 TO denotes to
T2866 4556-4559 DT denotes the
T2867 4560-4570 NN denotes conclusion
T2868 4571-4575 WDT denotes that
T2869 4576-4580 NNP denotes CD40
T2870 4581-4588 NNS denotes signals
T2871 4589-4592 MD denotes may
T2872 4593-4595 VB denotes be
T2873 4596-4605 JJ denotes important
T2874 4606-4608 IN denotes at
T2875 4609-4612 DT denotes the
T2876 4613-4620 JJ denotes initial
T2877 4621-4627 NNS denotes stages
T2878 4628-4630 IN denotes of
T2879 4631-4640 NN denotes arthritis
T2880 4641-4650 NN denotes induction
T2881 4650-4651 , denotes ,
T2882 4652-4655 CC denotes but
T2883 4656-4659 VBP denotes are
T2884 4660-4663 RB denotes not
T2885 4664-4672 VBN denotes required
T2886 4673-4677 RB denotes once
T2887 4678-4685 NN denotes disease
T2888 4686-4688 VBZ denotes is
T2889 4689-4700 VBN denotes established
T2890 4701-4704 CC denotes and
T2891 4705-4715 JJ denotes pathogenic
T2892 4716-4726 NNS denotes antibodies
T2893 4727-4730 VBP denotes are
T2894 4731-4738 RB denotes already
T2895 4739-4746 JJ denotes present
T2896 4747-4748 NNP denotes [
T2897 4748-4753 CD denotes 11,12
T2898 4753-4754 NNP denotes ]
T2899 4754-4755 . denotes .
T2900 4756-4764 VBN denotes Enhanced
T2901 4765-4775 NN denotes expression
T2902 4776-4778 IN denotes of
T2903 4779-4782 DT denotes the
T2904 4783-4786 NNP denotes TNF
T2905 4787-4795 NN denotes receptor
T2906 4796-4802 NN denotes family
T2907 4803-4809 NN denotes member
T2908 4810-4816 NNP denotes B-cell
T2909 4817-4827 VBG denotes activating
T2910 4828-4834 NN denotes factor
T2911 4835-4836 -LRB- denotes (
T2912 4836-4840 NNP denotes BAFF
T2913 4840-4841 -RRB- denotes )
T2914 4841-4842 , denotes ,
T2915 4843-4851 VBG denotes allowing
T2916 4852-4855 DT denotes the
T2917 4856-4864 NN denotes survival
T2918 4865-4867 IN denotes of
T2919 4868-4880 NN denotes autoantibody
T2920 4880-4881 : denotes -
T2921 4882-4891 VBG denotes producing
T2922 4892-4893 NNP denotes B
T2923 4894-4905 NNS denotes lymphocytes
T2924 4905-4906 , denotes ,
T2925 4907-4909 VBZ denotes is
T2926 4910-4914 RB denotes also
T2927 4915-4929 JJ denotes characteristic
T2928 4930-4933 IN denotes for
T2929 4934-4936 NNP denotes RA
T2930 4936-4937 , denotes ,
T2931 4938-4941 CC denotes and
T2932 4942-4953 NNS denotes antagonists
T2933 4954-4956 IN denotes of
T2934 4957-4961 NNP denotes BAFF
T2935 4962-4966 VBP denotes have
T2936 4967-4971 VBN denotes been
T2937 4972-4981 VBN denotes developed
T2938 4982-4984 TO denotes to
T2939 4985-4992 VB denotes counter
T2940 4993-4995 NNP denotes RA
T2941 4996-4997 NNP denotes [
T2942 4997-4999 CD denotes 13
T2943 4999-5000 NNP denotes ]
T2944 5000-5001 . denotes .
T2945 5002-5009 RB denotes Finally
T2946 5009-5010 , denotes ,
T2947 5011-5022 NN denotes lymphotoxin
T2948 5023-5024 NN denotes β
T2949 5025-5033 NN denotes receptor
T2950 5034-5044 NN denotes signalling
T2951 5045-5048 VBZ denotes has
T2952 5049-5053 VBN denotes been
T2953 5054-5064 VBN denotes implicated
T2954 5065-5067 IN denotes in
T2955 5068-5076 JJ denotes tertiary
T2956 5077-5085 JJ denotes lymphoid
T2957 5086-5091 NN denotes organ
T2958 5092-5101 NN denotes formation
T2959 5102-5104 IN denotes at
T2960 5105-5110 NNS denotes sites
T2961 5111-5113 IN denotes of
T2962 5114-5121 JJ denotes chronic
T2963 5122-5134 NN denotes inflammation
T2964 5135-5144 VBG denotes including
T2965 5145-5147 NNP denotes RA
T2966 5148-5149 NNP denotes [
T2967 5149-5151 CD denotes 13
T2968 5151-5152 NNP denotes ]
T2969 5152-5153 . denotes .
T2970 5154-5163 JJ denotes Toll-like
T2971 5164-5173 NNS denotes receptors
T2972 5174-5175 -LRB- denotes (
T2973 5175-5179 NNS denotes TLRs
T2974 5179-5180 -RRB- denotes )
T2975 5181-5185 VBP denotes have
T2976 5186-5190 VBN denotes been
T2977 5191-5201 VBN denotes implicated
T2978 5202-5204 IN denotes in
T2979 5205-5206 DT denotes a
T2980 5207-5214 NN denotes variety
T2981 5215-5217 IN denotes of
T2982 5218-5228 JJ denotes autoimmune
T2983 5229-5237 NNS denotes diseases
T2984 5238-5241 CC denotes and
T2985 5242-5245 VBP denotes are
T2986 5246-5255 JJ denotes potential
T2987 5256-5266 NNS denotes candidates
T2988 5267-5270 IN denotes for
T2989 5271-5279 VBG denotes inducing
T2990 5280-5295 JJ denotes NF-κB-dependent
T2991 5296-5308 NN denotes inflammation
T2992 5309-5311 IN denotes in
T2993 5312-5314 NNP denotes RA
T2994 5314-5315 . denotes .
T2995 5316-5318 IN denotes In
T2996 5319-5327 NN denotes addition
T2997 5328-5330 TO denotes to
T2998 5331-5340 JJ denotes microbial
T2999 5341-5348 NNS denotes ligands
T3000 5348-5349 , denotes ,
T3001 5350-5352 DT denotes an
T3002 5353-5363 VBG denotes increasing
T3003 5364-5370 NN denotes number
T3004 5371-5373 IN denotes of
T3005 5374-5384 JJ denotes endogenous
T3006 5385-5392 NNS denotes ligands
T3007 5393-5394 : denotes -
T3008 5395-5396 DT denotes a
T3009 5397-5402 NN denotes group
T3010 5403-5405 IN denotes of
T3011 5406-5414 NNS denotes proteins
T3012 5415-5422 VBN denotes derived
T3013 5423-5427 IN denotes from
T3014 5428-5432 NN denotes host
T3015 5433-5440 NNS denotes tissues
T3016 5441-5444 CC denotes and
T3017 5445-5450 NNS denotes cells
T3018 5451-5452 : denotes -
T3019 5453-5457 VB denotes have
T3020 5458-5462 VBN denotes been
T3021 5463-5471 VBN denotes reported
T3022 5472-5474 IN denotes as
T3023 5475-5484 NN denotes candidate
T3024 5485-5495 NNS denotes activators
T3025 5496-5498 IN denotes of
T3026 5499-5503 NNS denotes TLRs
T3027 5504-5512 VBG denotes inducing
T3028 5513-5522 JJ denotes so-called
T3029 5523-5530 JJ denotes sterile
T3030 5531-5543 NN denotes inflammation
T3031 5544-5545 -LRB- denotes (
T3032 5545-5553 VBN denotes reviewed
T3033 5554-5556 IN denotes in
T3034 5557-5558 NNP denotes [
T3035 5558-5563 CD denotes 14,15
T3036 5563-5564 NNP denotes ]
T3037 5564-5565 -RRB- denotes )
T3038 5565-5566 . denotes .
T3039 5567-5571 NNS denotes TLRs
T3040 5572-5575 VBP denotes are
T3041 5576-5585 VBN denotes expressed
T3042 5586-5588 IN denotes in
T3043 5589-5591 NNP denotes RA
T3044 5592-5600 JJ denotes synovial
T3045 5601-5608 NNS denotes tissues
T3046 5609-5612 CC denotes and
T3047 5613-5620 JJ denotes various
T3048 5621-5631 JJ denotes endogenous
T3049 5632-5639 NNS denotes ligands
T3050 5640-5643 VBP denotes are
T3051 5644-5651 JJ denotes present
T3052 5652-5658 IN denotes within
T3053 5659-5662 DT denotes the
T3054 5663-5671 JJ denotes inflamed
T3055 5672-5678 NNS denotes joints
T3056 5679-5681 IN denotes of
T3057 5682-5684 NNP denotes RA
T3058 5685-5693 NNS denotes patients
T3059 5693-5694 . denotes .
T3060 5695-5703 RB denotes Moreover
T3061 5703-5704 , denotes ,
T3062 5705-5711 NN denotes animal
T3063 5712-5718 NNS denotes models
T3064 5719-5724 VBG denotes using
T3065 5725-5728 NNP denotes TLR
T3066 5729-5737 NN denotes knockout
T3067 5738-5742 NNS denotes mice
T3068 5743-5745 CC denotes or
T3069 5746-5756 NNS denotes strategies
T3070 5757-5759 TO denotes to
T3071 5760-5765 VB denotes block
T3072 5766-5769 NNP denotes TLR
T3073 5770-5780 VBG denotes signalling
T3074 5781-5788 RB denotes clearly
T3075 5789-5797 VB denotes identify
T3076 5798-5811 JJ denotes TLR-dependent
T3077 5812-5824 NN denotes inflammation
T3078 5825-5827 IN denotes as
T3079 5828-5833 VBG denotes being
T3080 5834-5843 JJ denotes important
T3081 5844-5846 IN denotes in
T3082 5847-5850 DT denotes the
T3083 5851-5863 NN denotes pathogenesis
T3084 5864-5866 IN denotes of
T3085 5867-5870 DT denotes the
T3086 5871-5878 NN denotes disease
T3087 5878-5879 . denotes .
T3088 5880-5884 NNP denotes High
T3089 5885-5893 NN denotes mobility
T3090 5894-5899 NN denotes group
T3091 5900-5903 NN denotes box
T3092 5904-5915 JJ denotes chromosomal
T3093 5916-5923 NN denotes protein
T3094 5924-5925 CD denotes 1
T3095 5926-5927 -LRB- denotes (
T3096 5927-5932 CD denotes HMGB1
T3097 5932-5933 -RRB- denotes )
T3098 5933-5934 , denotes ,
T3099 5935-5936 DT denotes a
T3100 5937-5943 RB denotes highly
T3101 5944-5953 VBN denotes conserved
T3102 5954-5963 NN denotes chromatin
T3103 5964-5973 NN denotes component
T3104 5974-5978 WDT denotes that
T3105 5979-5982 MD denotes can
T3106 5983-5985 VB denotes be
T3107 5986-5994 RB denotes actively
T3108 5995-6003 VBN denotes secreted
T3109 6004-6006 IN denotes by
T3110 6007-6018 NNS denotes macrophages
T3111 6019-6021 CC denotes or
T3112 6022-6031 RB denotes passively
T3113 6032-6040 VBN denotes released
T3114 6041-6043 IN denotes by
T3115 6044-6052 JJ denotes necrotic
T3116 6053-6058 NNS denotes cells
T3117 6058-6059 , denotes ,
T3118 6060-6062 VBZ denotes is
T3119 6063-6066 CD denotes one
T3120 6067-6069 IN denotes of
T3121 6070-6073 DT denotes the
T3122 6074-6078 RBS denotes most
T3123 6079-6087 JJ denotes putative
T3124 6088-6098 JJ denotes endogenous
T3125 6099-6103 CD denotes TLR4
T3126 6104-6111 NNS denotes ligands
T3127 6112-6120 VBN denotes involved
T3128 6121-6123 IN denotes in
T3129 6124-6126 NNP denotes RA
T3130 6127-6136 NN denotes pathology
T3131 6136-6137 . denotes .
T3132 6138-6143 CD denotes HMGB1
T3133 6144-6146 VBZ denotes is
T3134 6147-6156 VBN denotes increased
T3135 6157-6159 IN denotes in
T3136 6160-6162 NNP denotes RA
T3137 6163-6171 JJ denotes synovial
T3138 6172-6178 NN denotes tissue
T3139 6179-6182 CC denotes and
T3140 6183-6188 NNP denotes HMGB1
T3141 6189-6201 VBG denotes neutralising
T3142 6202-6212 NNS denotes antibodies
T3143 6213-6215 CC denotes or
T3144 6216-6219 DT denotes the
T3145 6220-6232 JJ denotes antagonistic
T3146 6233-6237 NNP denotes BoxA
T3147 6238-6244 NN denotes domain
T3148 6245-6247 IN denotes of
T3149 6248-6253 NNP denotes HMGB1
T3150 6254-6261 VBP denotes protect
T3151 6262-6269 IN denotes against
T3152 6270-6286 JJ denotes collagen-induced
T3153 6287-6296 NNS denotes arthritis
T3154 6297-6299 IN denotes in
T3155 6300-6304 NNS denotes mice
T3156 6305-6306 NNP denotes [
T3157 6306-6308 CD denotes 16
T3158 6308-6309 NNP denotes ]
T3159 6309-6310 . denotes .
T3160 6311-6326 JJ denotes Myeloid-related
T3161 6327-6334 NN denotes protein
T3162 6335-6336 CD denotes 8
T3163 6337-6340 CC denotes and
T3164 6341-6356 JJ denotes myeloid-related
T3165 6357-6364 NN denotes protein
T3166 6365-6367 CD denotes 14
T3167 6367-6368 , denotes ,
T3168 6369-6386 JJ denotes damage-associated
T3169 6387-6396 JJ denotes molecular
T3170 6397-6404 NN denotes pattern
T3171 6405-6414 NNS denotes molecules
T3172 6415-6424 VBG denotes belonging
T3173 6425-6427 TO denotes to
T3174 6428-6431 DT denotes the
T3175 6432-6436 NNP denotes S100
T3176 6437-6443 NN denotes family
T3177 6444-6446 IN denotes of
T3178 6447-6462 JJ denotes calcium-binding
T3179 6463-6471 NNS denotes proteins
T3180 6471-6472 , denotes ,
T3181 6473-6476 VBP denotes are
T3182 6477-6481 RB denotes also
T3183 6482-6492 RB denotes abundantly
T3184 6493-6500 JJ denotes present
T3185 6501-6503 IN denotes in
T3186 6504-6506 NNP denotes RA
T3187 6507-6515 JJ denotes synovial
T3188 6516-6521 NN denotes fluid
T3189 6521-6522 , denotes ,
T3190 6523-6526 CC denotes and
T3191 6527-6531 VBP denotes have
T3192 6532-6536 VBN denotes been
T3193 6537-6546 VBN denotes suggested
T3194 6547-6549 TO denotes to
T3195 6550-6552 VB denotes be
T3196 6553-6561 VBN denotes involved
T3197 6562-6564 IN denotes in
T3198 6565-6577 JJ denotes TLR4-induced
T3199 6578-6585 NN denotes chronic
T3200 6586-6598 NN denotes inflammation
T3201 6599-6601 IN denotes in
T3202 6602-6604 NNP denotes RA
T3203 6605-6606 NNP denotes [
T3204 6606-6611 CD denotes 17,18
T3205 6611-6612 NNP denotes ]
T3206 6612-6613 . denotes .
T3207 6614-6619 JJ denotes Other
T3208 6620-6630 JJ denotes endogenous
T3209 6631-6634 NNP denotes TLR
T3210 6635-6642 NNS denotes ligands
T3211 6643-6647 WDT denotes that
T3212 6648-6651 MD denotes may
T3213 6652-6654 VB denotes be
T3214 6655-6663 VBN denotes involved
T3215 6664-6666 IN denotes in
T3216 6667-6669 NNP denotes RA
T3217 6670-6679 NN denotes pathology
T3218 6680-6683 VBP denotes are
T3219 6684-6697 JJ denotes extracellular
T3220 6698-6704 NN denotes matrix
T3221 6705-6715 NNS denotes components
T3222 6716-6720 JJ denotes such
T3223 6721-6723 IN denotes as
T3224 6724-6734 NN denotes fibrinogen
T3225 6734-6735 , denotes ,
T3226 6736-6747 NN denotes fibronectin
T3227 6747-6748 , denotes ,
T3228 6749-6757 NN denotes biglycan
T3229 6757-6758 , denotes ,
T3230 6759-6767 NN denotes tenascin
T3231 6768-6769 NNP denotes C
T3232 6769-6770 , denotes ,
T3233 6771-6774 CC denotes and
T3234 6775-6786 JJ denotes hyal-uronic
T3235 6787-6791 NN denotes acid
T3236 6792-6801 NNS denotes fragments
T3237 6802-6803 -LRB- denotes (
T3238 6803-6811 VBN denotes reviewed
T3239 6812-6814 IN denotes in
T3240 6815-6816 NNP denotes [
T3241 6816-6821 CD denotes 14,15
T3242 6821-6822 NNP denotes ]
T3243 6822-6823 -RRB- denotes )
T3244 6823-6824 . denotes .
T3245 6825-6833 RB denotes Together
T3246 6833-6834 , denotes ,
T3247 6835-6840 DT denotes these
T3248 6841-6848 NNS denotes studies
T3249 6849-6856 VBP denotes suggest
T3250 6857-6861 IN denotes that
T3251 6862-6869 JJ denotes several
T3252 6870-6873 NNP denotes TLR
T3253 6874-6881 NNS denotes ligands
T3254 6882-6884 IN denotes in
T3255 6885-6888 DT denotes the
T3256 6889-6897 JJ denotes inflamed
T3257 6898-6903 JJ denotes joint
T3258 6904-6910 NN denotes tissue
T3259 6911-6914 MD denotes may
T3260 6915-6925 VB denotes contribute
T3261 6926-6928 TO denotes to
T3262 6929-6934 JJ denotes NF-κB
T3263 6935-6945 NN denotes activation
T3264 6946-6949 CC denotes and
T3265 6950-6962 JJ denotes inflammatory
T3266 6963-6967 NN denotes gene
T3267 6968-6978 NN denotes expression
T3268 6979-6981 IN denotes in
T3269 6982-6984 NNP denotes RA
T3270 6984-6985 . denotes .
T5917 7024-7029 NN denotes NF-κB
T5918 7030-7038 NNS denotes proteins
T5919 7039-7042 VBP denotes are
T5920 7043-7054 VBN denotes sequestered
T5921 7055-7057 IN denotes in
T5922 7058-7061 DT denotes the
T5923 7062-7071 NN denotes cytoplasm
T5924 7072-7074 IN denotes as
T5925 7075-7081 NN denotes latent
T5926 7082-7091 NNS denotes complexes
T5927 7092-7094 IN denotes by
T5928 7095-7105 JJ denotes inhibitory
T5929 7106-7114 NNS denotes proteins
T5930 7115-7123 VBD denotes referred
T5931 7124-7126 TO denotes to
T5932 7127-7129 IN denotes as
T5933 7130-7139 NN denotes inhibitor
T5934 7140-7142 IN denotes of
T5935 7143-7148 NNP denotes NF-κB
T5936 7149-7150 -LRB- denotes (
T5937 7150-7153 NNP denotes IκB
T5938 7153-7154 -RRB- denotes )
T5939 7155-7163 NNS denotes proteins
T5940 7163-7164 , denotes ,
T5941 7165-7170 WDT denotes which
T5942 7171-7178 VBP denotes prevent
T5943 7179-7184 JJ denotes NF-κB
T5944 7185-7192 JJ denotes nuclear
T5945 7193-7206 NN denotes translocation
T5946 7207-7210 CC denotes and
T5947 7211-7214 NN denotes DNA
T5948 7215-7222 JJ denotes binding
T5949 7223-7224 NNP denotes [
T5950 7224-7226 CD denotes 19
T5951 7226-7227 NNP denotes ]
T5952 7227-7228 . denotes .
T5953 7229-7236 IN denotes Whereas
T5954 7237-7240 DT denotes the
T5955 7241-7249 NN denotes majority
T5956 7250-7252 IN denotes of
T5957 7253-7257 NNS denotes IκBs
T5958 7258-7259 -LRB- denotes (
T5959 7259-7263 NNP denotes IκBα
T5960 7263-7264 , denotes ,
T5961 7265-7269 NNP denotes IκBβ
T5962 7269-7270 , denotes ,
T5963 7271-7275 NNP denotes IκBε
T5964 7275-7276 , denotes ,
T5965 7277-7281 NNS denotes p105
T5966 7282-7283 -LRB- denotes (
T5967 7283-7287 RB denotes also
T5968 7288-7293 VBN denotes known
T5969 7294-7296 IN denotes as
T5970 7297-7303 NN denotes NF-κB1
T5971 7303-7304 -RRB- denotes )
T5972 7304-7305 , denotes ,
T5973 7306-7310 NN denotes p100
T5974 7311-7312 -LRB- denotes (
T5975 7312-7316 RB denotes also
T5976 7317-7322 VBN denotes known
T5977 7323-7325 IN denotes as
T5978 7326-7332 NN denotes NF-κB2
T5979 7332-7333 -RRB- denotes )
T5980 7333-7334 -RRB- denotes )
T5981 7335-7340 VBP denotes serve
T5982 7341-7343 IN denotes as
T5983 7344-7354 NNS denotes inhibitors
T5984 7355-7357 IN denotes of
T5985 7358-7363 NNP denotes NF-κB
T5986 7363-7364 , denotes ,
T5987 7365-7369 NNP denotes IκBξ
T5988 7370-7373 CC denotes and
T5989 7374-7379 JJ denotes Bcl-3
T5990 7380-7387 RB denotes instead
T5991 7388-7398 JJ denotes potentiate
T5992 7399-7404 NN denotes NF-κB
T5993 7405-7420 NN denotes transactivation
T5994 7421-7423 IN denotes in
T5995 7424-7427 DT denotes the
T5996 7428-7435 NN denotes nucleus
T5997 7435-7436 . denotes .
T5998 7437-7441 NN denotes p100
T5999 7442-7445 CC denotes and
T6000 7446-7450 NNS denotes p105
T6001 7451-7454 VBP denotes are
T6002 7455-7465 NNS denotes precursors
T6003 7466-7468 IN denotes of
T6004 7469-7472 DT denotes the
T6005 7473-7476 CD denotes p52
T6006 7477-7480 CC denotes and
T6007 7481-7484 CD denotes p50
T6008 7485-7490 JJ denotes NF-κB
T6009 7491-7499 NNS denotes subunits
T6010 7499-7500 , denotes ,
T6011 7501-7513 RB denotes respectively
T6012 7513-7514 . denotes .
T6013 7515-7520 EX denotes There
T6014 7521-7524 VBP denotes are
T6015 7525-7528 CD denotes two
T6016 7529-7535 JJ denotes unique
T6017 7536-7541 NN denotes NF-κB
T6018 7542-7552 VBG denotes signalling
T6019 7553-7561 NNS denotes pathways
T6020 7561-7562 , denotes ,
T6021 7563-7569 VBD denotes termed
T6022 7570-7579 JJ denotes canonical
T6023 7580-7581 -LRB- denotes (
T6024 7581-7583 CC denotes or
T6025 7584-7593 JJ denotes classical
T6026 7593-7594 -RRB- denotes )
T6027 7595-7598 CC denotes and
T6028 7599-7611 JJ denotes noncanonical
T6029 7612-7613 -LRB- denotes (
T6030 7613-7615 CC denotes or
T6031 7616-7627 NN denotes alternative
T6032 7627-7628 -RRB- denotes )
T6033 7629-7634 NN denotes NF-κB
T6034 7635-7643 NNS denotes pathways
T6035 7643-7644 . denotes .
T6036 7645-7648 DT denotes The
T6037 7649-7658 JJ denotes canonical
T6038 7659-7664 NN denotes NF-κB
T6039 7665-7672 NN denotes pathway
T6040 7673-7678 VBZ denotes plays
T6041 7679-7680 DT denotes a
T6042 7681-7686 JJ denotes major
T6043 7687-7691 NN denotes role
T6044 7692-7694 IN denotes in
T6045 7695-7701 NN denotes innate
T6046 7702-7705 CC denotes and
T6047 7706-7714 JJ denotes adaptive
T6048 7715-7723 NN denotes immunity
T6049 7723-7724 , denotes ,
T6050 7725-7728 CC denotes and
T6051 7729-7731 VBZ denotes is
T6052 7732-7741 VBN denotes triggered
T6053 7742-7744 IN denotes by
T6054 7745-7749 JJ denotes many
T6055 7750-7757 NNS denotes stimuli
T6056 7758-7767 VBG denotes including
T6057 7768-7783 JJ denotes proinflammatory
T6058 7784-7793 NNS denotes cytokines
T6059 7794-7795 -LRB- denotes (
T6060 7795-7798 IN denotes for
T6061 7799-7806 NN denotes example
T6062 7806-7807 , denotes ,
T6063 7808-7811 NNP denotes TNF
T6064 7811-7812 , denotes ,
T6065 7813-7817 NNP denotes IL-1
T6066 7817-7818 -RRB- denotes )
T6067 7818-7819 , denotes ,
T6068 7820-7828 NNS denotes antigens
T6069 7828-7829 , denotes ,
T6070 7830-7835 NNP denotes RANKL
T6071 7835-7836 , denotes ,
T6072 7837-7840 CC denotes and
T6073 7841-7844 NNP denotes TLR
T6074 7845-7852 NNS denotes ligands
T6075 7852-7853 . denotes .
T6076 7854-7859 JJ denotes NF-κB
T6077 7860-7870 JJ denotes signalling
T6078 7871-7880 VBN denotes initiated
T6079 7881-7883 IN denotes by
T6080 7884-7893 JJ denotes different
T6081 7894-7903 NNS denotes receptors
T6082 7904-7912 VBZ denotes requires
T6083 7913-7916 DT denotes the
T6084 7917-7926 NN denotes formation
T6085 7927-7929 IN denotes of
T6086 7930-7938 JJ denotes proximal
T6087 7939-7954 NN denotes protein-protein
T6088 7955-7967 NNS denotes interactions
T6089 7968-7972 WDT denotes that
T6090 7973-7976 VBP denotes are
T6091 7977-7982 RB denotes often
T6092 7983-7991 NN denotes receptor
T6093 7992-8000 JJ denotes specific
T6094 8000-8001 , denotes ,
T6095 8002-8005 CC denotes but
T6096 8006-8016 RB denotes ultimately
T6097 8017-8025 NN denotes converge
T6098 8026-8028 IN denotes in
T6099 8029-8032 DT denotes the
T6100 8033-8043 NN denotes activation
T6101 8044-8046 IN denotes of
T6102 8047-8050 DT denotes the
T6103 8051-8054 NNP denotes IκB
T6104 8055-8061 NN denotes kinase
T6105 8062-8063 -LRB- denotes (
T6106 8063-8066 NNP denotes IKK
T6107 8066-8067 -RRB- denotes )
T6108 8068-8075 JJ denotes complex
T6109 8075-8076 , denotes ,
T6110 8077-8082 WDT denotes which
T6111 8083-8091 VBZ denotes mediates
T6112 8092-8107 NN denotes phosphorylation
T6113 8108-8110 IN denotes of
T6114 8111-8114 DT denotes the
T6115 8115-8125 JJ denotes inhibitory
T6116 8126-8129 NNP denotes IκB
T6117 8130-8137 NN denotes protein
T6118 8138-8145 VBG denotes leading
T6119 8146-8148 TO denotes to
T6120 8149-8152 PRP$ denotes its
T6121 8153-8175 NN denotes K48-polyubiquitination
T6122 8176-8179 CC denotes and
T6123 8180-8191 NN denotes degradation
T6124 8192-8194 IN denotes by
T6125 8195-8198 DT denotes the
T6126 8199-8209 JJ denotes proteasome
T6127 8210-8211 NNP denotes [
T6128 8211-8213 CD denotes 20
T6129 8213-8214 NNP denotes ]
T6130 8214-8215 . denotes .
T6131 8216-8219 DT denotes The
T6132 8220-8223 NNP denotes IKK
T6133 8224-8231 NN denotes complex
T6134 8232-8234 VBZ denotes is
T6135 8235-8244 VBN denotes comprised
T6136 8245-8247 IN denotes of
T6137 8248-8251 DT denotes the
T6138 8252-8255 CD denotes two
T6139 8256-8265 JJ denotes catalytic
T6140 8266-8274 NNS denotes subunits
T6141 8275-8279 NNP denotes IKK1
T6142 8280-8283 CC denotes and
T6143 8284-8288 NNP denotes IKK2
T6144 8289-8290 -LRB- denotes (
T6145 8290-8294 RB denotes also
T6146 8295-8300 VBN denotes known
T6147 8301-8303 IN denotes as
T6148 8304-8308 NNP denotes IKKα
T6149 8309-8312 CC denotes and
T6150 8313-8317 NNP denotes IKKβ
T6151 8317-8318 -RRB- denotes )
T6152 8319-8322 CC denotes and
T6153 8323-8326 DT denotes the
T6154 8327-8337 JJ denotes regulatory
T6155 8338-8345 NN denotes subunit
T6156 8346-8351 NN denotes NF-κB
T6157 8352-8361 JJ denotes essential
T6158 8362-8371 NN denotes modulator
T6159 8372-8373 -LRB- denotes (
T6160 8373-8377 SYM denotes NEMO
T6161 8378-8379 : denotes -
T6162 8380-8384 RB denotes also
T6163 8385-8390 VBN denotes known
T6164 8391-8393 IN denotes as
T6165 8394-8398 NNP denotes IKKγ
T6166 8398-8399 -RRB- denotes )
T6167 8400-8401 -LRB- denotes (
T6168 8401-8407 NN denotes Figure
T6169 8408-8409 CD denotes 1
T6170 8409-8410 -RRB- denotes )
T6171 8410-8411 . denotes .
T6172 8412-8416 NNP denotes Gene
T6173 8417-8426 VBG denotes targeting
T6174 8427-8438 NNS denotes experiments
T6175 8439-8445 VBD denotes showed
T6176 8446-8450 IN denotes that
T6177 8451-8455 NNP denotes IKK2
T6178 8456-8459 CC denotes and
T6179 8460-8464 NNP denotes NEMO
T6180 8464-8465 , denotes ,
T6181 8466-8469 CC denotes but
T6182 8470-8473 RB denotes not
T6183 8474-8478 NNP denotes IKK1
T6184 8478-8479 , denotes ,
T6185 8480-8483 VBP denotes are
T6186 8484-8492 VBN denotes required
T6187 8493-8496 IN denotes for
T6188 8497-8506 JJ denotes canonical
T6189 8507-8512 NN denotes NF-κB
T6190 8513-8523 NN denotes activation
T6191 8524-8525 NNP denotes [
T6192 8525-8527 CD denotes 21
T6193 8527-8528 NNP denotes ]
T6194 8528-8529 . denotes .
T20179 8540-8549 NNP denotes Canonical
T20180 8550-8555 NNP denotes NF-κB
T20181 8556-8566 VBG denotes signalling
T20182 8567-8570 CC denotes and
T20183 8571-8579 JJ denotes negative
T20184 8580-8590 NNS denotes regulators
T20185 8590-8591 . denotes .
T20186 8592-8598 NNP denotes Ligand
T20187 8599-8609 NN denotes engagement
T20188 8610-8612 IN denotes of
T20189 8613-8621 JJ denotes specific
T20190 8622-8630 NN denotes membrane
T20191 8631-8640 NNS denotes receptors
T20192 8641-8645 JJ denotes such
T20193 8646-8648 IN denotes as
T20194 8649-8654 CD denotes TNFR1
T20195 8654-8655 , denotes ,
T20196 8656-8660 NNP denotes CD40
T20197 8660-8661 , denotes ,
T20198 8662-8666 NNP denotes RANK
T20199 8666-8667 , denotes ,
T20200 8668-8671 CC denotes and
T20201 8672-8676 CD denotes TLR4
T20202 8677-8684 NN denotes trigger
T20203 8685-8688 DT denotes the
T20204 8689-8700 NN denotes recruitment
T20205 8701-8703 IN denotes of
T20206 8704-8712 JJ denotes specific
T20207 8713-8720 NN denotes adaptor
T20208 8721-8729 NNS denotes proteins
T20209 8730-8731 -LRB- denotes (
T20210 8731-8734 NN denotes TNF
T20211 8735-8743 NN denotes receptor
T20212 8744-8756 JJ denotes 1-associated
T20213 8757-8762 NN denotes death
T20214 8763-8769 NN denotes domain
T20215 8770-8777 NN denotes protein
T20216 8778-8779 -LRB- denotes (
T20217 8779-8784 NNP denotes TRADD
T20218 8784-8785 -RRB- denotes )
T20219 8785-8786 , denotes ,
T20220 8787-8792 NNP denotes MyD88
T20221 8792-8793 , denotes ,
T20222 8794-8797 NNP denotes MAL
T20223 8797-8798 , denotes ,
T20224 8799-8802 NNP denotes TIR
T20225 8803-8820 JJ denotes domain-containing
T20226 8821-8837 JJ denotes adaptor-inducing
T20227 8838-8842 NNP denotes IFNβ
T20228 8843-8844 -LRB- denotes (
T20229 8844-8848 NNP denotes TRIF
T20230 8848-8849 -RRB- denotes )
T20231 8849-8850 -RRB- denotes )
T20232 8850-8851 , denotes ,
T20233 8852-8859 NNS denotes kinases
T20234 8860-8861 -LRB- denotes (
T20235 8861-8865 CD denotes RIP1
T20236 8865-8866 , denotes ,
T20237 8867-8872 NNP denotes IRAK1
T20238 8872-8873 , denotes ,
T20239 8874-8879 NNP denotes IRAK4
T20240 8879-8880 -RRB- denotes )
T20241 8880-8881 , denotes ,
T20242 8882-8885 CC denotes and
T20243 8886-8895 NN denotes ubiquitin
T20244 8896-8903 NNS denotes ligases
T20245 8904-8905 -LRB- denotes (
T20246 8905-8910 CD denotes TRAF2
T20247 8910-8911 , denotes ,
T20248 8912-8917 CD denotes TRAF6
T20249 8917-8918 , denotes ,
T20250 8919-8924 NNP denotes cIAP1
T20251 8924-8925 , denotes ,
T20252 8926-8931 NNP denotes cIAP2
T20253 8931-8932 -RRB- denotes )
T20254 8933-8935 TO denotes to
T20255 8936-8939 DT denotes the
T20256 8940-8948 NN denotes receptor
T20257 8948-8949 . denotes .
T20258 8950-8960 JJ denotes K63-linked
T20259 8961-8979 NN denotes polyubiquitination
T20260 8980-8982 IN denotes of
T20261 8983-8988 NNP denotes TRAFs
T20262 8988-8989 , denotes ,
T20263 8990-8994 NNP denotes RIP1
T20264 8995-8998 CC denotes and
T20265 8999-9004 NNP denotes IRAK1
T20266 9004-9005 , denotes ,
T20267 9006-9008 VBZ denotes is
T20268 9009-9019 VBN denotes recognised
T20269 9020-9022 IN denotes by
T20270 9023-9027 NNP denotes NEMO
T20271 9028-9031 CC denotes and
T20272 9032-9035 NNP denotes TAB
T20273 9036-9044 NNS denotes proteins
T20274 9044-9045 , denotes ,
T20275 9046-9055 VBG denotes resulting
T20276 9056-9058 IN denotes in
T20277 9059-9062 DT denotes the
T20278 9063-9074 NN denotes recruitment
T20279 9075-9078 CC denotes and
T20280 9079-9089 NN denotes activation
T20281 9090-9092 IN denotes of
T20282 9093-9105 RB denotes respectively
T20283 9106-9110 CD denotes IKK2
T20284 9111-9114 CC denotes and
T20285 9115-9119 CD denotes TAK1
T20286 9119-9120 . denotes .
T20287 9121-9125 CD denotes TAK1
T20288 9126-9130 RB denotes then
T20289 9131-9145 VBZ denotes phosphorylates
T20290 9146-9149 CC denotes and
T20291 9150-9159 VBZ denotes activates
T20292 9160-9164 NNP denotes IKK2
T20293 9164-9165 , denotes ,
T20294 9166-9171 WDT denotes which
T20295 9172-9174 IN denotes in
T20296 9175-9179 NN denotes turn
T20297 9180-9194 NNS denotes phosphorylates
T20298 9195-9199 NNP denotes IκBα
T20299 9199-9200 , denotes ,
T20300 9201-9211 VBG denotes triggering
T20301 9212-9215 PRP$ denotes its
T20302 9216-9226 JJ denotes K48-linked
T20303 9227-9241 NN denotes ubiquitination
T20304 9242-9245 CC denotes and
T20305 9246-9257 JJ denotes proteasomal
T20306 9258-9269 NN denotes degradation
T20307 9269-9270 . denotes .
T20308 9271-9275 DT denotes This
T20309 9276-9282 VBZ denotes allows
T20310 9283-9288 NNP denotes NF-κB
T20311 9289-9290 -LRB- denotes (
T20312 9290-9294 RB denotes here
T20313 9295-9300 VBN denotes shown
T20314 9301-9303 IN denotes as
T20315 9304-9305 DT denotes a
T20316 9306-9317 NN denotes heterodimer
T20317 9318-9320 IN denotes of
T20318 9321-9324 CD denotes p65
T20319 9325-9328 CC denotes and
T20320 9329-9332 CD denotes p50
T20321 9332-9333 -RRB- denotes )
T20322 9334-9336 TO denotes to
T20323 9337-9348 VB denotes translocate
T20324 9349-9351 TO denotes to
T20325 9352-9355 DT denotes the
T20326 9356-9363 NN denotes nucleus
T20327 9364-9367 CC denotes and
T20328 9368-9375 VB denotes promote
T20329 9376-9382 NN denotes target
T20330 9383-9387 NN denotes gene
T20331 9388-9398 NN denotes expression
T20332 9398-9399 . denotes .
T20333 9400-9405 CD denotes TRAF1
T20334 9405-9406 , denotes ,
T20335 9407-9412 WDT denotes which
T20336 9413-9416 VBZ denotes has
T20337 9417-9419 DT denotes no
T20338 9420-9429 NN denotes ubiquitin
T20339 9430-9436 NN denotes ligase
T20340 9437-9445 NN denotes activity
T20341 9445-9446 , denotes ,
T20342 9447-9450 MD denotes can
T20343 9451-9461 RB denotes negatively
T20344 9462-9470 VB denotes regulate
T20345 9471-9476 JJ denotes NF-κB
T20346 9477-9487 NN denotes activation
T20347 9487-9488 , denotes ,
T20348 9489-9493 JJS denotes most
T20349 9494-9502 RB denotes probably
T20350 9503-9505 IN denotes by
T20351 9506-9515 VBG denotes competing
T20352 9516-9520 IN denotes with
T20353 9521-9526 JJ denotes other
T20354 9527-9532 NNS denotes TRAFs
T20355 9532-9533 . denotes .
T20356 9534-9537 CD denotes A20
T20357 9538-9541 CC denotes and
T20358 9542-9546 NNP denotes CYLD
T20359 9547-9550 VBP denotes are
T20360 9551-9567 VBG denotes deubiquitinating
T20361 9568-9575 NNS denotes enzymes
T20362 9576-9580 WDT denotes that
T20363 9581-9588 VBP denotes control
T20364 9589-9594 JJ denotes NF-κB
T20365 9595-9605 NN denotes activation
T20366 9606-9608 IN denotes by
T20367 9609-9618 VBG denotes targeting
T20368 9619-9627 JJ denotes specific
T20369 9628-9638 VBG denotes signalling
T20370 9639-9647 NNS denotes proteins
T20371 9648-9657 VBG denotes including
T20372 9658-9662 NNP denotes RIP1
T20373 9663-9666 CC denotes and
T20374 9667-9672 NNP denotes TRAF6
T20375 9672-9673 , denotes ,
T20376 9674-9676 TO denotes to
T20377 9677-9682 WDT denotes which
T20378 9683-9687 PRP denotes they
T20379 9688-9691 VBP denotes are
T20380 9692-9701 VBN denotes recruited
T20381 9702-9707 VBG denotes using
T20382 9708-9716 JJ denotes specific
T20383 9717-9734 JJ denotes ubiquitin-binding
T20384 9735-9742 NN denotes adaptor
T20385 9743-9751 NNS denotes proteins
T20386 9752-9756 JJ denotes such
T20387 9757-9759 IN denotes as
T20388 9760-9766 NNP denotes ABIN-1
T20389 9767-9770 CC denotes and
T20390 9771-9774 CD denotes p62
T20391 9774-9775 . denotes .
T20392 9776-9783 NN denotes miR-146
T20393 9784-9786 VBZ denotes is
T20394 9787-9794 VBN denotes thought
T20395 9795-9797 TO denotes to
T20396 9798-9808 RB denotes negatively
T20397 9809-9817 VB denotes regulate
T20398 9818-9821 NNP denotes TLR
T20399 9822-9832 JJ denotes signalling
T20400 9833-9835 IN denotes by
T20401 9836-9846 VBG denotes inhibiting
T20402 9847-9857 NN denotes expression
T20403 9858-9860 IN denotes of
T20404 9861-9866 NNP denotes IRAK1
T20405 9867-9870 CC denotes and
T20406 9871-9876 NNP denotes TRAF6
T20407 9876-9877 . denotes .
T20408 9878-9885 RB denotes Finally
T20409 9885-9886 , denotes ,
T20410 9887-9890 NNP denotes TLR
T20411 9891-9901 NN denotes signalling
T20412 9902-9905 MD denotes can
T20413 9906-9910 RB denotes also
T20414 9911-9913 VB denotes be
T20415 9914-9923 VBN denotes inhibited
T20416 9924-9926 IN denotes by
T20417 9927-9930 DT denotes the
T20418 9931-9944 NN denotes transmembrane
T20419 9945-9952 NN denotes protein
T20420 9953-9959 NNP denotes SIGIRR
T20421 9959-9960 , denotes ,
T20422 9961-9966 WDT denotes which
T20423 9967-9970 VBZ denotes has
T20424 9971-9975 VBN denotes been
T20425 9976-9984 VBN denotes proposed
T20426 9985-9987 TO denotes to
T20427 9988-9995 VB denotes compete
T20428 9996-10000 IN denotes with
T20429 10001-10005 CD denotes TLR4
T20430 10006-10009 IN denotes for
T20431 10010-10017 JJ denotes binding
T20432 10018-10020 TO denotes to
T20433 10021-10026 NNP denotes IRAK1
T20434 10027-10030 CC denotes and
T20435 10031-10036 NNP denotes TRAF6
T20436 10036-10037 . denotes .
T20437 10038-10041 DT denotes The
T20438 10042-10052 NN denotes expression
T20439 10053-10055 IN denotes of
T20440 10056-10060 JJ denotes many
T20441 10061-10063 IN denotes of
T20442 10064-10069 DT denotes these
T20443 10070-10078 JJ denotes negative
T20444 10079-10089 JJ denotes regulatory
T20445 10090-10099 NNS denotes molecules
T20446 10100-10102 VBZ denotes is
T20447 10103-10108 JJ denotes NF-κB
T20448 10109-10118 JJ denotes dependent
T20449 10118-10119 , denotes ,
T20450 10120-10131 VBG denotes implicating
T20451 10132-10136 PRP denotes them
T20452 10137-10139 IN denotes in
T20453 10140-10143 DT denotes the
T20454 10144-10152 JJ denotes negative
T20455 10153-10161 NN denotes feedback
T20456 10162-10172 NN denotes regulation
T20457 10173-10175 IN denotes of
T20458 10176-10181 JJ denotes NF-κB
T20459 10182-10192 NN denotes activation
T20460 10192-10193 . denotes .
T20461 10194-10198 NNP denotes ABIN
T20462 10198-10199 , denotes ,
T20463 10200-10211 JJ denotes A20-binding
T20464 10212-10221 NN denotes inhibitor
T20465 10222-10224 IN denotes of
T20466 10225-10230 NN denotes NF-κB
T20467 10230-10231 : denotes ;
T20468 10232-10236 NNP denotes cIAP
T20469 10236-10237 , denotes ,
T20470 10238-10246 JJ denotes cellular
T20471 10247-10256 NN denotes inhibitor
T20472 10257-10259 IN denotes of
T20473 10260-10269 NN denotes apoptosis
T20474 10269-10270 : denotes ;
T20475 10271-10275 NNP denotes CYLD
T20476 10275-10276 , denotes ,
T20477 10277-10292 NN denotes cylindromatosis
T20478 10292-10293 : denotes ;
T20479 10294-10297 NNP denotes IKK
T20480 10297-10298 , denotes ,
T20481 10299-10302 NNP denotes IκB
T20482 10303-10309 NN denotes kinase
T20483 10309-10310 : denotes ;
T20484 10311-10314 NNP denotes IκB
T20485 10314-10315 , denotes ,
T20486 10316-10325 NN denotes inhibitor
T20487 10326-10328 IN denotes of
T20488 10329-10334 NN denotes NF-κB
T20489 10334-10335 : denotes ;
T20490 10336-10340 NNP denotes IRAK
T20491 10340-10341 , denotes ,
T20492 10342-10358 JJ denotes IL-1R-associated
T20493 10359-10365 NN denotes kinase
T20494 10365-10366 : denotes ;
T20495 10367-10372 NNP denotes MyD88
T20496 10372-10373 , denotes ,
T20497 10374-10381 JJ denotes myeloid
T20498 10382-10397 NN denotes differentiation
T20499 10398-10405 JJ denotes primary
T20500 10406-10414 NN denotes response
T20501 10415-10419 NN denotes gene
T20502 10420-10422 CD denotes 88
T20503 10422-10423 : denotes ;
T20504 10424-10428 NNP denotes NEMO
T20505 10428-10429 , denotes ,
T20506 10430-10435 NNP denotes NF-κB
T20507 10436-10445 JJ denotes essential
T20508 10446-10455 NN denotes modulator
T20509 10455-10456 : denotes ;
T20510 10457-10459 NNP denotes NF
T20511 10459-10460 , denotes ,
T20512 10461-10468 JJ denotes nuclear
T20513 10469-10475 NN denotes factor
T20514 10475-10476 : denotes ;
T20515 10477-10481 NNP denotes RANK
T20516 10481-10482 , denotes ,
T20517 10483-10491 NN denotes receptor
T20518 10492-10501 NN denotes activator
T20519 10502-10504 IN denotes of
T20520 10505-10510 NNP denotes NF-κB
T20521 10510-10511 : denotes ;
T20522 10512-10516 NNP denotes RIP1
T20523 10516-10517 , denotes ,
T20524 10518-10526 NN denotes receptor
T20525 10527-10538 VBG denotes interacting
T20526 10539-10546 NN denotes protein
T20527 10547-10548 CD denotes 1
T20528 10548-10549 : denotes ;
T20529 10550-10556 NNP denotes SIGIRR
T20530 10556-10557 , denotes ,
T20531 10558-10583 JJ denotes single-immunoglobulinIL-1
T20532 10584-10600 JJ denotes receptor-related
T20533 10600-10601 : denotes ;
T20534 10602-10605 NNP denotes TIR
T20535 10605-10606 , denotes ,
T20536 10607-10616 JJ denotes Toll-like
T20537 10617-10628 NNP denotes receptor/IL
T20538 10628-10630 CD denotes -1
T20539 10630-10631 NN denotes R
T20540 10631-10632 : denotes ;
T20541 10633-10637 NNP denotes TRAF
T20542 10637-10638 , denotes ,
T20543 10639-10642 NNP denotes TNF
T20544 10643-10662 VBD denotes receptor-associated
T20545 10663-10669 NN denotes factor
T20546 10669-10670 : denotes ;
T20547 10671-10674 NNP denotes TLR
T20548 10674-10675 , denotes ,
T20549 10676-10685 JJ denotes Toll-like
T20550 10686-10694 NN denotes receptor
T20551 10694-10695 : denotes ;
T20552 10696-10699 NNP denotes TNF
T20553 10699-10700 , denotes ,
T20554 10701-10707 NN denotes tumour
T20555 10708-10716 NN denotes necrosis
T20556 10717-10723 NN denotes factor
T20557 10723-10724 . denotes .
T6195 10725-10728 CD denotes One
T6196 10729-10731 IN denotes of
T6197 10732-10735 DT denotes the
T6198 10736-10740 JJS denotes best
T6199 10741-10748 VBN denotes studied
T6200 10749-10754 NNP denotes NF-κB
T6201 10755-10765 VBG denotes signalling
T6202 10766-10774 NNS denotes pathways
T6203 10775-10777 VBZ denotes is
T6204 10778-10781 DT denotes the
T6205 10782-10785 NNP denotes TNF
T6206 10786-10793 NN denotes pathway
T6207 10793-10794 . denotes .
T6208 10795-10798 NNP denotes TNF
T6209 10799-10810 NN denotes stimulation
T6210 10811-10818 NNS denotes results
T6211 10819-10821 IN denotes in
T6212 10822-10825 DT denotes the
T6213 10826-10837 NN denotes recruitment
T6214 10838-10840 IN denotes of
T6215 10841-10844 NNP denotes TNF
T6216 10845-10866 JJ denotes receptor-1-associated
T6217 10867-10872 NN denotes death
T6218 10873-10879 NN denotes domain
T6219 10880-10881 -LRB- denotes (
T6220 10881-10886 NNP denotes TRADD
T6221 10886-10887 -RRB- denotes )
T6222 10888-10895 NN denotes protein
T6223 10896-10899 CC denotes and
T6224 10900-10902 IN denotes of
T6225 10903-10911 NN denotes receptor
T6226 10912-10923 VBG denotes interacting
T6227 10924-10931 NN denotes protein
T6228 10932-10933 CD denotes 1
T6229 10934-10935 -LRB- denotes (
T6230 10935-10939 NN denotes RIP1
T6231 10939-10940 -RRB- denotes )
T6232 10940-10941 , denotes ,
T6233 10942-10947 WDT denotes which
T6234 10948-10956 VBP denotes function
T6235 10957-10959 IN denotes as
T6236 10960-10967 NN denotes adaptor
T6237 10968-10976 NNS denotes proteins
T6238 10977-10980 IN denotes for
T6239 10981-10984 DT denotes the
T6240 10985-10987 CD denotes E3
T6241 10988-10997 NN denotes ubiquitin
T6242 10998-11005 VBZ denotes ligases
T6243 11006-11009 NNP denotes TNF
T6244 11010-11029 JJ denotes receptor-associated
T6245 11030-11036 NN denotes factor
T6246 11037-11038 -LRB- denotes (
T6247 11038-11042 NNP denotes TRAF
T6248 11042-11043 -RRB- denotes )
T6249 11044-11045 CD denotes 2
T6250 11046-11049 CC denotes and
T6251 11050-11055 CD denotes TRAF5
T6252 11055-11056 , denotes ,
T6253 11057-11062 WDT denotes which
T6254 11063-11065 IN denotes in
T6255 11066-11070 NN denotes turn
T6256 11071-11075 NN denotes bind
T6257 11076-11079 DT denotes the
T6258 11080-11082 CD denotes E3
T6259 11083-11092 NN denotes ubiquitin
T6260 11093-11100 VBZ denotes ligases
T6261 11101-11109 JJ denotes cellular
T6262 11110-11119 NN denotes inhibitor
T6263 11120-11122 IN denotes of
T6264 11123-11132 NN denotes apoptosis
T6265 11133-11134 -LRB- denotes (
T6266 11134-11138 NNP denotes cIAP
T6267 11138-11139 -RRB- denotes )
T6268 11140-11141 CD denotes 1
T6269 11142-11145 CC denotes and
T6270 11146-11151 NNP denotes cIAP2
T6271 11152-11153 -LRB- denotes (
T6272 11153-11159 NNP denotes Figure
T6273 11160-11161 CD denotes 1
T6274 11161-11162 -RRB- denotes )
T6275 11162-11163 . denotes .
T6276 11164-11166 IN denotes On
T6277 11167-11170 NNP denotes TNF
T6278 11171-11182 NN denotes stimulation
T6279 11182-11183 , denotes ,
T6280 11184-11196 JJ denotes TNF-receptor
T6281 11197-11202 VBN denotes bound
T6282 11203-11207 NNP denotes RIP1
T6283 11208-11210 VBZ denotes is
T6284 11211-11218 RB denotes rapidly
T6285 11219-11227 VBN denotes modified
T6286 11228-11230 IN denotes by
T6287 11231-11241 JJ denotes K63-linked
T6288 11242-11255 NN denotes polyubiquitin
T6289 11256-11262 NNS denotes chains
T6290 11262-11263 . denotes .
T6291 11264-11271 CD denotes TRAF2/5
T6292 11272-11275 CC denotes and
T6293 11276-11283 NNP denotes cIAP1/2
T6294 11284-11287 VBP denotes are
T6295 11288-11292 JJ denotes good
T6296 11293-11303 NNS denotes candidates
T6297 11304-11307 IN denotes for
T6298 11308-11312 NNP denotes RIP1
T6299 11313-11327 NN denotes ubiquitination
T6300 11327-11328 , denotes ,
T6301 11329-11332 CC denotes but
T6302 11333-11336 DT denotes the
T6303 11337-11345 JJ denotes specific
T6304 11346-11350 NN denotes role
T6305 11351-11353 IN denotes of
T6306 11354-11358 DT denotes each
T6307 11359-11361 VBZ denotes is
T6308 11362-11367 RB denotes still
T6309 11368-11375 JJ denotes unclear
T6310 11375-11376 . denotes .
T6311 11377-11380 DT denotes The
T6312 11381-11394 NN denotes polyubiquitin
T6313 11395-11401 NNS denotes chains
T6314 11402-11404 IN denotes on
T6315 11405-11409 NNP denotes RIP1
T6316 11410-11413 VBP denotes are
T6317 11414-11422 VBN denotes believed
T6318 11423-11425 TO denotes to
T6319 11426-11432 VB denotes create
T6320 11433-11434 DT denotes a
T6321 11435-11443 NN denotes scaffold
T6322 11444-11446 TO denotes to
T6323 11447-11454 VB denotes recruit
T6324 11455-11458 DT denotes the
T6325 11459-11462 NNP denotes IKK
T6326 11463-11466 CC denotes and
T6327 11467-11471 CD denotes TAK1
T6328 11472-11479 JJ denotes complex
T6329 11480-11483 IN denotes via
T6330 11484-11487 DT denotes the
T6331 11488-11505 JJ denotes ubiquitin-binding
T6332 11506-11514 NNS denotes proteins
T6333 11515-11519 NNP denotes NEMO
T6334 11520-11523 CC denotes and
T6335 11524-11530 NNP denotes TAB1/2
T6336 11530-11531 , denotes ,
T6337 11532-11544 RB denotes respectively
T6338 11544-11545 . denotes .
T6339 11546-11549 DT denotes The
T6340 11550-11556 JJ denotes recent
T6341 11557-11571 NN denotes identification
T6342 11572-11574 IN denotes of
T6343 11575-11576 DT denotes a
T6344 11577-11585 JJ denotes distinct
T6345 11586-11591 CD denotes E2/E3
T6346 11592-11598 NN denotes enzyme
T6347 11599-11606 NN denotes complex
T6348 11607-11611 WDT denotes that
T6349 11612-11620 VBZ denotes modifies
T6350 11621-11625 NNP denotes NEMO
T6351 11626-11630 IN denotes with
T6352 11631-11637 JJ denotes linear
T6353 11638-11651 NN denotes polyubiquitin
T6354 11652-11658 NNS denotes chains
T6355 11659-11662 CC denotes and
T6356 11663-11665 VBZ denotes is
T6357 11666-11675 JJ denotes essential
T6358 11676-11679 IN denotes for
T6359 11680-11693 JJ denotes TNF-activated
T6360 11694-11699 JJ denotes NF-κB
T6361 11700-11710 NN denotes signalling
T6362 11711-11715 VBZ denotes adds
T6363 11716-11723 JJ denotes further
T6364 11724-11734 NN denotes complexity
T6365 11735-11736 NNP denotes [
T6366 11736-11738 CD denotes 22
T6367 11738-11739 NNP denotes ]
T6368 11739-11740 . denotes .
T6369 11741-11744 DT denotes The
T6370 11745-11750 JJ denotes exact
T6371 11751-11755 NN denotes role
T6372 11756-11758 IN denotes of
T6373 11759-11775 JJ denotes protein-anchored
T6374 11776-11789 NN denotes polyubiquitin
T6375 11790-11796 NNS denotes chains
T6376 11797-11804 VBZ denotes remains
T6377 11805-11812 JJ denotes unclear
T6378 11812-11813 , denotes ,
T6379 11814-11816 IN denotes as
T6380 11817-11819 PRP denotes it
T6381 11820-11823 VBD denotes was
T6382 11824-11832 RB denotes recently
T6383 11833-11842 VBN denotes suggested
T6384 11843-11847 IN denotes that
T6385 11848-11858 JJ denotes unanchored
T6386 11859-11872 NN denotes polyubiquitin
T6387 11873-11879 NNS denotes chains
T6388 11880-11883 MD denotes can
T6389 11884-11892 RB denotes directly
T6390 11893-11901 VB denotes activate
T6391 11902-11905 DT denotes the
T6392 11906-11910 CD denotes TAK1
T6393 11911-11918 JJ denotes complex
T6394 11919-11920 NNP denotes [
T6395 11920-11922 CD denotes 23
T6396 11922-11923 NNP denotes ]
T6397 11923-11924 . denotes .
T6398 11925-11932 JJ denotes Similar
T6399 11933-11943 JJ denotes signalling
T6400 11944-11954 NNS denotes principles
T6401 11955-11960 VBP denotes apply
T6402 11961-11963 TO denotes to
T6403 11964-11969 JJ denotes other
T6404 11970-11979 NNS denotes receptors
T6405 11979-11980 . denotes .
T6406 11981-11984 IN denotes For
T6407 11985-11992 NN denotes example
T6408 11992-11993 , denotes ,
T6409 11994-11998 CD denotes TLR4
T6410 11999-12010 NN denotes stimulation
T6411 12011-12013 IN denotes by
T6412 12014-12032 NN denotes lipopolysaccharide
T6413 12033-12040 VBZ denotes induces
T6414 12041-12044 DT denotes the
T6415 12045-12056 NN denotes recruitment
T6416 12057-12059 IN denotes of
T6417 12060-12067 NNP denotes Toll/IL
T6418 12067-12069 CD denotes -1
T6419 12070-12078 NN denotes receptor
T6420 12079-12086 NN denotes adaptor
T6421 12087-12094 NN denotes protein
T6422 12095-12096 -LRB- denotes (
T6423 12096-12100 RB denotes also
T6424 12101-12109 VBD denotes referred
T6425 12110-12112 TO denotes to
T6426 12113-12115 IN denotes as
T6427 12116-12119 NNP denotes Mal
T6428 12119-12120 -RRB- denotes )
T6429 12121-12124 CC denotes and
T6430 12125-12137 JJ denotes TRIF-related
T6431 12138-12145 NN denotes adaptor
T6432 12146-12154 NN denotes molecule
T6433 12155-12156 -LRB- denotes (
T6434 12156-12160 NNP denotes TRAM
T6435 12160-12161 -RRB- denotes )
T6436 12161-12162 , denotes ,
T6437 12163-12168 WDT denotes which
T6438 12169-12173 RBS denotes most
T6439 12174-12182 RB denotes probably
T6440 12183-12188 VBP denotes serve
T6441 12189-12191 IN denotes as
T6442 12192-12200 VBG denotes bridging
T6443 12201-12208 NNS denotes factors
T6444 12209-12211 TO denotes to
T6445 12212-12219 VB denotes recruit
T6446 12220-12227 JJ denotes myeloid
T6447 12228-12243 NN denotes differentiation
T6448 12244-12251 JJ denotes primary
T6449 12252-12260 NN denotes response
T6450 12261-12265 NN denotes gene
T6451 12266-12268 CD denotes 88
T6452 12269-12270 -LRB- denotes (
T6453 12270-12275 NNP denotes MyD88
T6454 12275-12276 -RRB- denotes )
T6455 12277-12280 CC denotes and
T6456 12281-12284 NNP denotes TIR
T6457 12285-12302 JJ denotes domain-containing
T6458 12303-12319 JJ denotes adaptor-inducing
T6459 12320-12324 NNP denotes IFNβ
T6460 12325-12326 -LRB- denotes (
T6461 12326-12330 NNP denotes TRIF
T6462 12330-12331 -RRB- denotes )
T6463 12331-12332 , denotes ,
T6464 12333-12345 RB denotes respectively
T6465 12345-12346 . denotes .
T6466 12347-12352 CD denotes MyD88
T6467 12353-12355 IN denotes in
T6468 12356-12360 NN denotes turn
T6469 12361-12369 NNS denotes recruits
T6470 12370-12377 NNS denotes members
T6471 12378-12380 IN denotes of
T6472 12381-12384 DT denotes the
T6473 12385-12401 JJ denotes IL-1R-associated
T6474 12402-12408 NN denotes kinase
T6475 12409-12410 -LRB- denotes (
T6476 12410-12414 NNP denotes IRAK
T6477 12414-12415 -RRB- denotes )
T6478 12416-12422 NN denotes family
T6479 12423-12426 CC denotes and
T6480 12427-12432 CD denotes TRAF6
T6481 12432-12433 , denotes ,
T6482 12434-12441 VBG denotes leading
T6483 12442-12444 TO denotes to
T6484 12445-12460 NN denotes oligomerisation
T6485 12461-12464 CC denotes and
T6486 12465-12483 NN denotes selfubiquitination
T6487 12484-12486 IN denotes of
T6488 12487-12492 CD denotes TRAF6
T6489 12493-12494 NNP denotes [
T6490 12494-12496 CD denotes 24
T6491 12496-12497 NNP denotes ]
T6492 12497-12498 . denotes .
T6493 12499-12503 NNP denotes TRIF
T6494 12504-12508 RB denotes also
T6495 12509-12517 VBZ denotes recruits
T6496 12518-12523 CD denotes TRAF6
T6497 12524-12525 NNP denotes [
T6498 12525-12527 CD denotes 25
T6499 12527-12528 NNP denotes ]
T6500 12529-12532 CC denotes and
T6501 12533-12537 NNP denotes RIP1
T6502 12538-12539 NNP denotes [
T6503 12539-12541 CD denotes 26
T6504 12541-12542 NNP denotes ]
T6505 12543-12546 IN denotes via
T6506 12547-12548 DT denotes a
T6507 12549-12555 JJ denotes direct
T6508 12556-12567 NN denotes interaction
T6509 12567-12568 . denotes .
T6510 12569-12573 DT denotes Both
T6511 12574-12582 NNS denotes pathways
T6512 12583-12587 RB denotes then
T6513 12588-12596 VBP denotes activate
T6514 12597-12601 CD denotes TAK1
T6515 12602-12605 CC denotes and
T6516 12606-12609 NNP denotes IKK
T6517 12610-12612 IN denotes in
T6518 12613-12614 DT denotes a
T6519 12615-12639 JJ denotes ubiquitination-dependent
T6520 12640-12646 NN denotes manner
T6521 12647-12654 JJ denotes similar
T6522 12655-12657 TO denotes to
T6523 12658-12661 DT denotes the
T6524 12662-12665 NNP denotes TNF
T6525 12666-12673 NN denotes pathway
T6526 12674-12675 -LRB- denotes (
T6527 12675-12681 NN denotes Figure
T6528 12682-12683 CD denotes 1
T6529 12683-12684 -RRB- denotes )
T6530 12684-12685 . denotes .
T6531 12686-12689 DT denotes The
T6532 12690-12702 JJ denotes noncanonical
T6533 12703-12708 NN denotes NF-κB
T6534 12709-12716 NN denotes pathway
T6535 12717-12720 MD denotes can
T6536 12721-12723 VB denotes be
T6537 12724-12733 VBN denotes activated
T6538 12734-12736 IN denotes by
T6539 12737-12740 DT denotes the
T6540 12741-12752 NN denotes lymphotoxin
T6541 12753-12754 NN denotes β
T6542 12755-12763 NN denotes receptor
T6543 12763-12764 , denotes ,
T6544 12765-12769 NN denotes BAFF
T6545 12770-12778 NN denotes receptor
T6546 12778-12779 , denotes ,
T6547 12780-12784 NNP denotes CD40
T6548 12784-12785 , denotes ,
T6549 12786-12789 CC denotes and
T6550 12790-12794 NNP denotes RANK
T6551 12795-12796 -LRB- denotes (
T6552 12796-12802 NNP denotes Figure
T6553 12803-12804 CD denotes 2
T6554 12804-12805 -RRB- denotes )
T6555 12805-12806 . denotes .
T6556 12807-12809 IN denotes In
T6557 12810-12814 DT denotes this
T6558 12815-12822 NN denotes pathway
T6559 12822-12823 , denotes ,
T6560 12824-12828 NN denotes p100
T6561 12829-12831 VBZ denotes is
T6562 12832-12841 VBN denotes processed
T6563 12842-12844 IN denotes by
T6564 12845-12848 DT denotes the
T6565 12849-12859 JJ denotes proteasome
T6566 12860-12862 TO denotes to
T6567 12863-12866 VB denotes p52
T6568 12866-12867 , denotes ,
T6569 12868-12873 WDT denotes which
T6570 12874-12882 RB denotes together
T6571 12883-12887 IN denotes with
T6572 12888-12891 DT denotes the
T6573 12892-12896 NNP denotes RelB
T6574 12897-12902 NNP denotes NF-κB
T6575 12903-12910 NN denotes subunit
T6576 12911-12920 VBZ denotes regulates
T6577 12921-12922 DT denotes a
T6578 12923-12931 JJ denotes distinct
T6579 12932-12935 NN denotes set
T6580 12936-12938 IN denotes of
T6581 12939-12945 NN denotes target
T6582 12946-12951 NNS denotes genes
T6583 12952-12956 WDT denotes that
T6584 12957-12964 VBP denotes control
T6585 12965-12971 JJ denotes B-cell
T6586 12972-12983 NN denotes development
T6587 12983-12984 , denotes ,
T6588 12985-12994 JJ denotes secondary
T6589 12995-13003 JJ denotes lymphoid
T6590 13004-13009 NN denotes organ
T6591 13010-13021 NN denotes development
T6592 13021-13022 , denotes ,
T6593 13023-13026 CC denotes and
T6594 13027-13045 NN denotes osteoclastogenesis
T6595 13046-13047 NNP denotes [
T6596 13047-13049 CD denotes 27
T6597 13049-13050 NNP denotes ]
T6598 13051-13054 DT denotes The
T6599 13055-13067 JJ denotes noncanonical
T6600 13068-13073 NN denotes NF-κB
T6601 13074-13081 NN denotes pathway
T6602 13082-13084 VBZ denotes is
T6603 13085-13093 RB denotes strictly
T6604 13094-13103 JJ denotes dependent
T6605 13104-13106 IN denotes on
T6606 13107-13111 NNP denotes IKK1
T6607 13111-13112 , denotes ,
T6608 13113-13118 WDT denotes which
T6609 13119-13121 VBZ denotes is
T6610 13122-13131 VBN denotes activated
T6611 13132-13136 IN denotes upon
T6612 13137-13152 NN denotes phosphorylation
T6613 13153-13155 IN denotes by
T6614 13156-13161 JJ denotes NF-κB
T6615 13162-13170 VBG denotes inducing
T6616 13171-13177 NN denotes kinase
T6617 13178-13179 -LRB- denotes (
T6618 13179-13182 NNP denotes NIK
T6619 13182-13183 -RRB- denotes )
T6620 13183-13184 . denotes .
T6621 13185-13188 NNP denotes NIK
T6622 13189-13191 VBZ denotes is
T6623 13192-13205 RB denotes predominantly
T6624 13206-13215 VBN denotes regulated
T6625 13216-13218 IN denotes at
T6626 13219-13222 DT denotes the
T6627 13223-13241 JJ denotes post-translational
T6628 13242-13247 NN denotes level
T6629 13248-13251 CC denotes and
T6630 13252-13254 VBZ denotes is
T6631 13255-13262 JJ denotes present
T6632 13263-13265 IN denotes at
T6633 13266-13275 RB denotes extremely
T6634 13276-13279 JJ denotes low
T6635 13280-13286 NNS denotes levels
T6636 13287-13289 IN denotes in
T6637 13290-13294 JJS denotes most
T6638 13295-13299 NN denotes cell
T6639 13300-13305 NNS denotes types
T6640 13305-13306 . denotes .
T6641 13307-13309 IN denotes In
T6642 13310-13322 JJ denotes unstimulated
T6643 13323-13328 NNS denotes cells
T6644 13328-13329 , denotes ,
T6645 13330-13333 NNP denotes NIK
T6646 13334-13340 VBZ denotes occurs
T6647 13341-13343 IN denotes in
T6648 13344-13345 DT denotes a
T6649 13346-13357 JJ denotes cytoplasmic
T6650 13358-13365 NN denotes complex
T6651 13366-13370 IN denotes with
T6652 13371-13376 CD denotes TRAF2
T6653 13376-13377 , denotes ,
T6654 13378-13383 CD denotes TRAF3
T6655 13383-13384 , denotes ,
T6656 13385-13388 CC denotes and
T6657 13389-13396 NNP denotes cIAP1/2
T6658 13396-13397 , denotes ,
T6659 13398-13403 WDT denotes which
T6660 13404-13425 VBZ denotes K48-polyubiquitinates
T6661 13426-13429 NNP denotes NIK
T6662 13429-13430 , denotes ,
T6663 13431-13438 VBG denotes leading
T6664 13439-13441 TO denotes to
T6665 13442-13445 PRP$ denotes its
T6666 13446-13456 JJ denotes continuous
T6667 13457-13468 NN denotes degradation
T6668 13469-13471 IN denotes by
T6669 13472-13475 DT denotes the
T6670 13476-13486 JJ denotes proteasome
T6671 13486-13487 . denotes .
T6672 13488-13496 NN denotes Receptor
T6673 13497-13505 NN denotes ligation
T6674 13506-13509 VBZ denotes has
T6675 13510-13514 VBN denotes been
T6676 13515-13520 VBN denotes shown
T6677 13521-13524 RB denotes not
T6678 13525-13529 RB denotes only
T6679 13530-13532 TO denotes to
T6680 13533-13539 VB denotes remove
T6681 13540-13545 CD denotes TRAF3
T6682 13546-13550 IN denotes from
T6683 13551-13555 DT denotes this
T6684 13556-13563 JJ denotes complex
T6685 13564-13566 IN denotes by
T6686 13567-13577 VBG denotes recruiting
T6687 13578-13580 PRP denotes it
T6688 13581-13583 TO denotes to
T6689 13584-13587 DT denotes the
T6690 13588-13596 NN denotes receptor
T6691 13596-13597 , denotes ,
T6692 13598-13601 CC denotes but
T6693 13602-13606 RB denotes also
T6694 13607-13609 TO denotes to
T6695 13610-13617 VB denotes attract
T6696 13618-13623 CD denotes TRAF2
T6697 13624-13627 CC denotes and
T6698 13628-13635 NNP denotes cIAP1/2
T6699 13635-13636 , denotes ,
T6700 13637-13642 WDT denotes which
T6701 13643-13646 VBP denotes are
T6702 13647-13656 JJ denotes essential
T6703 13657-13660 IN denotes for
T6704 13661-13671 JJ denotes subsequent
T6705 13672-13677 CD denotes TRAF3
T6706 13678-13689 NN denotes degradation
T6707 13689-13690 . denotes .
T6708 13691-13694 PDT denotes All
T6709 13695-13699 DT denotes this
T6710 13700-13711 VBZ denotes contributes
T6711 13712-13714 TO denotes to
T6712 13715-13724 VBG denotes releasing
T6713 13725-13728 NNP denotes NIK
T6714 13729-13733 IN denotes from
T6715 13734-13737 PRP$ denotes its
T6716 13738-13750 JJ denotes constitutive
T6717 13751-13762 NN denotes degradation
T6718 13762-13763 , denotes ,
T6719 13764-13773 VBG denotes resulting
T6720 13774-13776 IN denotes in
T6721 13777-13780 NNP denotes NIK
T6722 13781-13793 NN denotes accumulation
T6723 13794-13797 CC denotes and
T6724 13798-13802 CD denotes IKK1
T6725 13803-13818 NN denotes phosphorylation
T6726 13819-13820 NNP denotes [
T6727 13820-13825 CD denotes 28,29
T6728 13825-13826 NNP denotes ]
T6729 13827-13828 -LRB- denotes (
T6730 13828-13834 NNP denotes Figure
T6731 13835-13836 CD denotes 2
T6732 13836-13837 -RRB- denotes )
T6733 13837-13838 . denotes .
T21854 13849-13861 NNP denotes Noncanonical
T21855 13862-13867 NNP denotes NF-κB
T21856 13868-13878 VBG denotes signalling
T21857 13878-13879 . denotes .
T21858 13880-13884 CD denotes CD40
T21859 13885-13888 CC denotes and
T21860 13889-13893 NNP denotes RANK
T21861 13894-13897 MD denotes can
T21862 13898-13906 VB denotes activate
T21863 13907-13910 DT denotes the
T21864 13911-13923 JJ denotes noncanonical
T21865 13924-13929 NN denotes NF-κB
T21866 13930-13937 NN denotes pathway
T21867 13938-13942 WDT denotes that
T21868 13943-13945 VBZ denotes is
T21869 13946-13955 JJ denotes dependent
T21870 13956-13958 IN denotes on
T21871 13959-13964 JJ denotes NF-κB
T21872 13965-13973 VBG denotes inducing
T21873 13974-13980 NN denotes kinase
T21874 13981-13982 -LRB- denotes (
T21875 13982-13985 NNP denotes NIK
T21876 13985-13986 -RRB- denotes )
T21877 13987-13997 NN denotes expression
T21878 13998-14004 NNS denotes levels
T21879 14004-14005 . denotes .
T21880 14006-14008 IN denotes In
T21881 14009-14021 JJ denotes unstimulated
T21882 14022-14027 NNS denotes cells
T21883 14028-14031 NNP denotes NIK
T21884 14032-14037 VBZ denotes forms
T21885 14038-14039 DT denotes a
T21886 14040-14049 JJ denotes cytosolic
T21887 14050-14057 NN denotes complex
T21888 14058-14062 IN denotes with
T21889 14063-14066 DT denotes the
T21890 14067-14076 NN denotes ubiquitin
T21891 14077-14084 VBZ denotes ligases
T21892 14085-14090 CD denotes TRAF2
T21893 14090-14091 , denotes ,
T21894 14092-14097 CD denotes TRAF3
T21895 14098-14101 CC denotes and
T21896 14102-14109 NNP denotes cIAP1/2
T21897 14109-14110 , denotes ,
T21898 14111-14116 WDT denotes which
T21899 14117-14128 VBZ denotes facilitates
T21900 14129-14132 DT denotes the
T21901 14133-14143 JJ denotes K48-linked
T21902 14144-14162 NN denotes polyubiquitination
T21903 14163-14166 CC denotes and
T21904 14167-14178 JJ denotes proteasomal
T21905 14179-14190 NN denotes degradation
T21906 14191-14193 IN denotes of
T21907 14194-14197 NNP denotes NIK
T21908 14197-14198 , denotes ,
T21909 14199-14206 VBG denotes keeping
T21910 14207-14210 NNP denotes NIK
T21911 14211-14217 NNS denotes levels
T21912 14218-14221 JJ denotes low
T21913 14221-14222 . denotes .
T21914 14223-14227 IN denotes Upon
T21915 14228-14234 JJ denotes ligand
T21916 14235-14242 JJ denotes binding
T21917 14242-14243 , denotes ,
T21918 14244-14249 CD denotes TRAF3
T21919 14250-14252 VBZ denotes is
T21920 14253-14262 VBN denotes recruited
T21921 14263-14265 TO denotes to
T21922 14266-14269 DT denotes the
T21923 14270-14278 NN denotes receptor
T21924 14278-14279 , denotes ,
T21925 14280-14285 WRB denotes where
T21926 14286-14291 CD denotes TRAF2
T21927 14292-14299 VBZ denotes directs
T21928 14300-14314 JJ denotes nondegradative
T21929 14315-14325 JJ denotes K63-linked
T21930 14326-14344 NN denotes polyubiquitination
T21931 14345-14347 IN denotes of
T21932 14348-14355 NNP denotes cIAP1/2
T21933 14355-14356 , denotes ,
T21934 14357-14366 VBG denotes resulting
T21935 14367-14369 IN denotes in
T21936 14370-14375 PRP$ denotes their
T21937 14376-14386 NN denotes activation
T21938 14386-14387 . denotes .
T21939 14388-14400 RB denotes Subsequently
T21940 14401-14408 JJ denotes cIAP1/2
T21941 14409-14416 VBZ denotes directs
T21942 14417-14420 PRP$ denotes its
T21943 14421-14431 JJ denotes K48-linked
T21944 14432-14450 NN denotes polyubiquitination
T21945 14451-14453 TO denotes to
T21946 14454-14459 CD denotes TRAF3
T21947 14459-14460 , denotes ,
T21948 14461-14467 RB denotes rather
T21949 14468-14472 IN denotes than
T21950 14473-14476 NNP denotes NIK
T21951 14476-14477 . denotes .
T21952 14478-14480 IN denotes As
T21953 14481-14482 DT denotes a
T21954 14483-14489 NN denotes result
T21955 14489-14490 , denotes ,
T21956 14491-14496 CD denotes TRAF3
T21957 14497-14499 VBZ denotes is
T21958 14500-14508 JJ denotes degraded
T21959 14509-14512 CC denotes and
T21960 14513-14516 NNP denotes NIK
T21961 14517-14519 VBZ denotes is
T21962 14520-14530 VBN denotes stabilised
T21963 14530-14531 , denotes ,
T21964 14532-14541 VBG denotes resulting
T21965 14542-14544 IN denotes in
T21966 14545-14554 VBN denotes increased
T21967 14555-14558 NNP denotes NIK
T21968 14559-14565 NNS denotes levels
T21969 14566-14568 IN denotes in
T21970 14569-14572 DT denotes the
T21971 14573-14577 NN denotes cell
T21972 14577-14578 . denotes .
T21973 14579-14582 NNP denotes NIK
T21974 14583-14587 RB denotes then
T21975 14588-14602 VBZ denotes phosphorylates
T21976 14603-14606 CC denotes and
T21977 14607-14616 VBZ denotes activates
T21978 14617-14621 NNP denotes IKK1
T21979 14621-14622 , denotes ,
T21980 14623-14628 WDT denotes which
T21981 14629-14637 VBZ denotes mediates
T21982 14638-14643 NNP denotes NF-κB
T21983 14644-14648 CD denotes p100
T21984 14649-14664 NN denotes phosphorylation
T21985 14664-14665 . denotes .
T21986 14666-14670 DT denotes This
T21987 14671-14673 VBZ denotes is
T21988 14674-14682 VBN denotes followed
T21989 14683-14685 IN denotes by
T21990 14686-14696 JJ denotes K48-linked
T21991 14697-14715 NN denotes polyubiquitination
T21992 14716-14719 CC denotes and
T21993 14720-14727 JJ denotes partial
T21994 14728-14739 JJ denotes proteasomal
T21995 14740-14751 NN denotes degradation
T21996 14752-14754 IN denotes of
T21997 14755-14759 CD denotes p100
T21998 14760-14762 TO denotes to
T21999 14763-14766 CD denotes p52
T22000 14766-14767 , denotes ,
T22001 14768-14773 WDT denotes which
T22002 14774-14779 VBZ denotes forms
T22003 14780-14781 DT denotes a
T22004 14782-14793 NN denotes heterodimer
T22005 14794-14798 IN denotes with
T22006 14799-14803 NNP denotes RelB
T22007 14804-14806 TO denotes to
T22008 14807-14815 VB denotes activate
T22009 14816-14829 NN denotes transcription
T22010 14829-14830 . denotes .
T22011 14831-14835 JJ denotes Next
T22012 14836-14838 TO denotes to
T22013 14839-14844 CD denotes TRAF3
T22014 14844-14845 , denotes ,
T22015 14846-14851 CD denotes TRAF1
T22016 14852-14855 VBZ denotes has
T22017 14856-14860 RB denotes also
T22018 14861-14865 VBN denotes been
T22019 14866-14876 VBN denotes identified
T22020 14877-14879 IN denotes as
T22021 14880-14881 DT denotes a
T22022 14882-14890 JJ denotes negative
T22023 14891-14900 NN denotes regulator
T22024 14901-14903 IN denotes of
T22025 14904-14908 DT denotes this
T22026 14909-14916 NN denotes pathway
T22027 14916-14917 , denotes ,
T22028 14918-14922 JJS denotes most
T22029 14923-14931 RB denotes probably
T22030 14932-14934 IN denotes by
T22031 14935-14944 VBG denotes competing
T22032 14945-14949 IN denotes with
T22033 14950-14955 JJ denotes other
T22034 14956-14959 NNP denotes TNF
T22035 14960-14979 JJ denotes receptor-associated
T22036 14980-14987 NNS denotes factors
T22037 14987-14988 . denotes .
T22038 14989-14993 NNP denotes cIAP
T22039 14993-14994 , denotes ,
T22040 14995-15003 JJ denotes cellular
T22041 15004-15013 NN denotes inhibitor
T22042 15014-15016 IN denotes of
T22043 15017-15026 NN denotes apoptosis
T22044 15026-15027 : denotes ;
T22045 15028-15031 NNP denotes IKK
T22046 15031-15032 , denotes ,
T22047 15033-15036 NNP denotes IκB
T22048 15037-15043 NN denotes kinase
T22049 15043-15044 : denotes ;
T22050 15045-15047 NNP denotes NF
T22051 15047-15048 , denotes ,
T22052 15049-15056 JJ denotes nuclear
T22053 15057-15063 NN denotes factor
T22054 15063-15064 : denotes ;
T22055 15065-15069 NNP denotes RANK
T22056 15069-15070 , denotes ,
T22057 15071-15079 NN denotes receptor
T22058 15080-15089 NN denotes activator
T22059 15090-15092 IN denotes of
T22060 15093-15098 NN denotes NF-κB
T22061 15098-15099 : denotes ;
T22062 15100-15104 NNP denotes TRAF
T22063 15104-15105 , denotes ,
T22064 15106-15109 NNP denotes TNF
T22065 15110-15129 VBD denotes receptor-associated
T22066 15130-15136 NN denotes factor
T22067 15136-15137 : denotes ;
T22068 15138-15141 NNP denotes TNF
T22069 15141-15142 , denotes ,
T22070 15143-15149 NN denotes tumour
T22071 15150-15158 NN denotes necrosis
T22072 15159-15165 NN denotes factor
T22073 15165-15166 . denotes .
T6734 15167-15169 PRP denotes It
T6735 15170-15176 MD denotes should
T6736 15177-15179 VB denotes be
T6737 15180-15189 VBN denotes mentioned
T6738 15190-15194 IN denotes that
T6739 15195-15199 NNP denotes CD40
T6740 15199-15200 , denotes ,
T6741 15201-15212 NN denotes lymphotoxin
T6742 15213-15214 NN denotes β
T6743 15215-15223 NN denotes receptor
T6744 15224-15227 CC denotes and
T6745 15228-15232 VB denotes RANK
T6746 15233-15240 VB denotes mediate
T6747 15241-15244 DT denotes the
T6748 15245-15255 NN denotes activation
T6749 15256-15258 IN denotes of
T6750 15259-15263 DT denotes both
T6751 15264-15273 JJ denotes canonical
T6752 15274-15277 CC denotes and
T6753 15278-15290 JJ denotes noncanonical
T6754 15291-15296 NN denotes NF-κB
T6755 15297-15307 VBG denotes signalling
T6756 15308-15316 NNS denotes pathways
T6757 15316-15317 . denotes .
T6758 15318-15322 IN denotes Upon
T6759 15323-15330 JJ denotes binding
T6760 15331-15333 IN denotes of
T6761 15334-15339 PRP$ denotes their
T6762 15340-15346 NN denotes ligand
T6763 15346-15347 , denotes ,
T6764 15348-15352 NNP denotes CD40
T6765 15353-15356 CC denotes and
T6766 15357-15361 NNP denotes RANK
T6767 15362-15370 NN denotes interact
T6768 15371-15375 IN denotes with
T6769 15376-15383 JJ denotes several
T6770 15384-15388 NNP denotes TRAF
T6771 15389-15396 NNS denotes members
T6772 15396-15397 , denotes ,
T6773 15398-15407 VBG denotes including
T6774 15408-15413 CD denotes TRAF1
T6775 15413-15414 , denotes ,
T6776 15415-15420 CD denotes TRAF2
T6777 15420-15421 , denotes ,
T6778 15422-15427 CD denotes TRAF3
T6779 15427-15428 , denotes ,
T6780 15429-15434 CD denotes TRAF5
T6781 15434-15435 , denotes ,
T6782 15436-15439 CC denotes and
T6783 15440-15445 NNP denotes TRAF6
T6784 15445-15446 , denotes ,
T6785 15447-15450 CC denotes and
T6786 15451-15455 DT denotes this
T6787 15456-15461 VBZ denotes leads
T6788 15462-15464 TO denotes to
T6789 15465-15468 DT denotes the
T6790 15469-15480 NN denotes proteolysis
T6791 15481-15483 IN denotes of
T6792 15484-15488 DT denotes both
T6793 15489-15494 CD denotes TRAF2
T6794 15495-15498 CC denotes and
T6795 15499-15504 CD denotes TRAF3
T6796 15504-15505 , denotes ,
T6797 15506-15511 WDT denotes which
T6798 15512-15522 VBZ denotes represents
T6799 15523-15525 DT denotes an
T6800 15526-15535 JJ denotes important
T6801 15536-15540 NN denotes step
T6802 15541-15543 IN denotes in
T6803 15544-15547 DT denotes the
T6804 15548-15558 NN denotes activation
T6805 15559-15561 IN denotes of
T6806 15562-15565 DT denotes the
T6807 15566-15578 JJ denotes noncanonical
T6808 15579-15586 NN denotes pathway
T6809 15587-15589 IN denotes as
T6810 15590-15599 VBN denotes described
T6811 15600-15605 IN denotes above
T6812 15605-15606 . denotes .
T6813 15607-15615 JJ denotes Specific
T6814 15616-15620 NNP denotes TRAF
T6815 15621-15630 NNS denotes molecules
T6816 15631-15634 VBP denotes are
T6817 15635-15645 VBN denotes associated
T6818 15646-15650 IN denotes with
T6819 15651-15662 VBG denotes overlapping
T6820 15663-15666 CC denotes and
T6821 15667-15675 JJ denotes distinct
T6822 15676-15689 JJ denotes CD40-mediated
T6823 15690-15699 NNS denotes functions
T6824 15699-15700 . denotes .
T6825 15701-15704 IN denotes For
T6826 15705-15712 NN denotes example
T6827 15712-15713 , denotes ,
T6828 15714-15716 IN denotes in
T6829 15717-15718 NNP denotes B
T6830 15719-15724 NNS denotes cells
T6831 15725-15730 NNP denotes TRAF6
T6832 15731-15733 VBZ denotes is
T6833 15734-15742 VBN denotes required
T6834 15743-15746 IN denotes for
T6835 15747-15760 JJ denotes CD40-mediated
T6836 15761-15764 NNP denotes JNK
T6837 15765-15775 NN denotes activation
T6838 15776-15779 CC denotes and
T6839 15780-15784 NN denotes IL-6
T6840 15785-15795 NN denotes production
T6841 15795-15796 , denotes ,
T6842 15797-15802 IN denotes while
T6843 15803-15808 CD denotes TRAF2
T6844 15809-15811 VBZ denotes is
T6845 15812-15820 VBN denotes required
T6846 15821-15824 IN denotes for
T6847 15825-15835 NN denotes activation
T6848 15836-15838 IN denotes of
T6849 15839-15844 NNP denotes NF-κB
T6850 15844-15845 , denotes ,
T6851 15846-15849 CC denotes and
T6852 15850-15855 CD denotes TRAF3
T6853 15856-15862 VBZ denotes serves
T6854 15863-15865 IN denotes as
T6855 15866-15867 DT denotes a
T6856 15868-15876 JJ denotes negative
T6857 15877-15886 NN denotes regulator
T6858 15887-15889 IN denotes of
T6859 15890-15894 NNP denotes CD40
T6860 15895-15905 VBG denotes signalling
T6861 15906-15907 NNP denotes [
T6862 15907-15912 CD denotes 30,31
T6863 15912-15913 NNP denotes ]
T6864 15913-15914 . denotes .
T8787 15962-15967 IN denotes Since
T8788 15968-15973 NNP denotes NF-κB
T8789 15974-15984 NN denotes activation
T8790 15985-15987 VBZ denotes is
T8791 15988-15990 RB denotes so
T8792 15991-15998 JJ denotes crucial
T8793 15999-16001 TO denotes to
T8794 16002-16006 JJ denotes many
T8795 16007-16015 JJ denotes cellular
T8796 16016-16025 NNS denotes processes
T8797 16025-16026 , denotes ,
T8798 16027-16028 DT denotes a
T8799 16029-16034 JJ denotes tight
T8800 16035-16045 NN denotes regulation
T8801 16046-16048 IN denotes of
T8802 16049-16052 DT denotes the
T8803 16053-16058 NN denotes NF-κB
T8804 16059-16069 VBG denotes signalling
T8805 16070-16077 NN denotes pathway
T8806 16078-16081 CC denotes and
T8807 16082-16085 DT denotes the
T8808 16086-16091 NNS denotes genes
T8809 16092-16094 PRP denotes it
T8810 16095-16102 VBZ denotes induces
T8811 16103-16105 VBZ denotes is
T8812 16106-16108 DT denotes an
T8813 16109-16117 JJ denotes absolute
T8814 16118-16129 NN denotes requirement
T8815 16130-16132 TO denotes to
T8816 16133-16142 VB denotes fine-tune
T8817 16143-16146 DT denotes the
T8818 16147-16159 JJ denotes inflammatory
T8819 16160-16168 NN denotes response
T8820 16168-16169 . denotes .
T8821 16170-16178 RB denotes Moreover
T8822 16178-16179 , denotes ,
T8823 16180-16191 VBG denotes terminating
T8824 16192-16194 DT denotes an
T8825 16195-16200 JJ denotes NF-κB
T8826 16201-16209 NN denotes response
T8827 16210-16212 VBZ denotes is
T8828 16213-16222 JJ denotes essential
T8829 16223-16225 TO denotes to
T8830 16226-16233 VB denotes prevent
T8831 16234-16244 JJ denotes persistent
T8832 16245-16250 NN denotes NF-κB
T8833 16251-16261 NN denotes activation
T8834 16262-16266 WDT denotes that
T8835 16267-16270 MD denotes may
T8836 16271-16275 VB denotes lead
T8837 16276-16278 TO denotes to
T8838 16279-16286 JJ denotes chronic
T8839 16287-16299 NN denotes inflammation
T8840 16300-16306 CC denotes and/or
T8841 16307-16320 NN denotes tumorigenesis
T8842 16320-16321 . denotes .
T8843 16322-16324 TO denotes To
T8844 16325-16332 VB denotes achieve
T8845 16333-16337 DT denotes this
T8846 16337-16338 , denotes ,
T8847 16339-16344 NNS denotes cells
T8848 16345-16351 VBP denotes employ
T8849 16352-16361 JJ denotes different
T8850 16362-16372 NNS denotes mechanisms
T8851 16372-16373 , denotes ,
T8852 16374-16383 VBG denotes including
T8853 16384-16387 DT denotes the
T8854 16388-16398 NN denotes expression
T8855 16399-16401 IN denotes of
T8856 16402-16412 JJ denotes inhibitory
T8857 16413-16421 NNS denotes proteins
T8858 16422-16426 WDT denotes that
T8859 16427-16439 VBP denotes downregulate
T8860 16440-16445 JJ denotes NF-κB
T8861 16446-16456 JJ denotes signalling
T8862 16457-16458 NNP denotes [
T8863 16458-16460 CD denotes 32
T8864 16460-16461 NNP denotes ]
T8865 16461-16462 . denotes .
T8866 16463-16468 IN denotes Below
T8867 16469-16471 PRP denotes we
T8868 16472-16476 VBP denotes give
T8869 16477-16479 DT denotes an
T8870 16480-16488 NN denotes overview
T8871 16489-16491 IN denotes of
T8872 16492-16493 DT denotes a
T8873 16494-16500 NN denotes number
T8874 16501-16503 IN denotes of
T8875 16504-16512 NNS denotes proteins
T8876 16513-16517 WDT denotes that
T8877 16518-16521 VBP denotes are
T8878 16522-16530 VBN denotes involved
T8879 16531-16533 IN denotes in
T8880 16534-16537 DT denotes the
T8881 16538-16547 NN denotes dampening
T8882 16548-16550 CC denotes or
T8883 16551-16562 NN denotes termination
T8884 16563-16565 IN denotes of
T8885 16566-16569 DT denotes the
T8886 16570-16575 NNP denotes NF-κB
T8887 16576-16584 NN denotes response
T8888 16584-16585 , denotes ,
T8889 16586-16590 DT denotes some
T8890 16591-16593 IN denotes of
T8891 16594-16598 PRP denotes them
T8892 16599-16604 IN denotes under
T8893 16605-16608 DT denotes the
T8894 16609-16616 NN denotes control
T8895 16617-16619 IN denotes of
T8896 16620-16625 JJ denotes NF-κB
T8897 16626-16632 PRP denotes itself
T8898 16633-16636 CC denotes and
T8899 16637-16641 RB denotes thus
T8900 16642-16648 VBG denotes acting
T8901 16649-16651 IN denotes in
T8902 16652-16653 DT denotes a
T8903 16654-16662 JJ denotes negative
T8904 16663-16671 NN denotes feedback
T8905 16672-16676 NN denotes loop
T8906 16676-16677 . denotes .
T8907 16678-16680 IN denotes In
T8908 16681-16689 NN denotes addition
T8909 16689-16690 , denotes ,
T8910 16691-16693 PRP denotes we
T8911 16694-16701 VBP denotes discuss
T8912 16702-16705 DT denotes the
T8913 16706-16715 JJ denotes potential
T8914 16716-16720 NN denotes role
T8915 16721-16723 IN denotes of
T8916 16724-16729 DT denotes these
T8917 16730-16735 JJ denotes NF-κB
T8918 16736-16746 NN denotes inhibitory
T8919 16747-16754 NNS denotes factors
T8920 16755-16757 IN denotes in
T8921 16758-16761 DT denotes the
T8922 16762-16777 NN denotes immunopathology
T8923 16778-16780 IN denotes of
T8924 16781-16783 NNP denotes RA
T8925 16783-16784 . denotes .
T8926 16785-16792 JJ denotes Several
T8927 16793-16798 JJ denotes other
T8928 16799-16807 NNS denotes proteins
T8929 16808-16816 VBN denotes involved
T8930 16817-16819 IN denotes in
T8931 16820-16823 DT denotes the
T8932 16824-16832 JJ denotes negative
T8933 16833-16843 NN denotes regulation
T8934 16844-16846 IN denotes of
T8935 16847-16862 JJ denotes NF-κB-dependent
T8936 16863-16875 JJ denotes inflammatory
T8937 16876-16885 NNS denotes responses
T8938 16885-16886 , denotes ,
T8939 16887-16891 JJ denotes such
T8940 16892-16894 IN denotes as
T8941 16895-16901 NNS denotes MyD88s
T8942 16901-16902 , denotes ,
T8943 16903-16909 NNP denotes IRAK-M
T8944 16909-16910 , denotes ,
T8945 16911-16914 CC denotes and
T8946 16915-16921 NNP denotes TOLLIP
T8947 16921-16922 , denotes ,
T8948 16923-16927 VBP denotes have
T8949 16928-16932 VBN denotes been
T8950 16933-16942 VBN denotes described
T8951 16943-16944 -LRB- denotes (
T8952 16944-16952 VBN denotes reviewed
T8953 16953-16955 IN denotes in
T8954 16956-16957 NNP denotes [
T8955 16957-16959 CD denotes 33
T8956 16959-16960 NNP denotes ]
T8957 16960-16961 -RRB- denotes )
T8958 16961-16962 . denotes .
T8959 16963-16968 DT denotes These
T8960 16969-16977 NNS denotes proteins
T8961 16978-16981 VBP denotes are
T8962 16982-16985 RB denotes not
T8963 16986-16995 VBN denotes discussed
T8964 16996-17000 RB denotes here
T8965 17000-17001 , denotes ,
T8966 17002-17007 IN denotes since
T8967 17008-17009 DT denotes a
T8968 17010-17014 NN denotes link
T8969 17015-17019 IN denotes with
T8970 17020-17022 NNP denotes RA
T8971 17023-17032 NN denotes pathology
T8972 17033-17036 VBZ denotes has
T8973 17037-17040 RB denotes not
T8974 17041-17044 RB denotes yet
T8975 17045-17049 VBN denotes been
T8976 17050-17068 JJ denotes reported. Although
T8977 17069-17073 NNP denotes IKK1
T8978 17074-17076 VBZ denotes is
T8979 17077-17078 DT denotes a
T8980 17079-17087 JJ denotes critical
T8981 17088-17097 NN denotes component
T8982 17098-17100 IN denotes of
T8983 17101-17104 DT denotes the
T8984 17105-17118 JJ denotes non-canonical
T8985 17119-17124 NN denotes NF-κB
T8986 17125-17132 NN denotes pathway
T8987 17132-17133 , denotes ,
T8988 17134-17136 PRP denotes it
T8989 17137-17143 MD denotes should
T8990 17144-17146 VB denotes be
T8991 17147-17156 VBN denotes mentioned
T8992 17157-17161 IN denotes that
T8993 17162-17166 DT denotes this
T8994 17167-17173 NN denotes kinase
T8995 17174-17178 RB denotes also
T8996 17179-17184 VBZ denotes plays
T8997 17185-17186 DT denotes a
T8998 17187-17196 JJ denotes prominent
T8999 17197-17201 NN denotes role
T9000 17202-17204 IN denotes in
T9001 17205-17208 DT denotes the
T9002 17209-17217 JJ denotes negative
T9003 17218-17228 NN denotes regulation
T9004 17229-17231 IN denotes of
T9005 17232-17236 DT denotes both
T9006 17237-17246 JJ denotes canonical
T9007 17247-17250 CC denotes and
T9008 17251-17263 JJ denotes noncanonical
T9009 17264-17269 NN denotes NF-κB
T9010 17270-17278 NNS denotes pathways
T9011 17278-17279 . denotes .
T9012 17280-17291 NNS denotes Macrophages
T9013 17292-17296 IN denotes from
T9014 17297-17311 JJ denotes IKK1-deficient
T9015 17312-17316 NNS denotes mice
T9016 17317-17319 CC denotes or
T9017 17320-17327 VB denotes knockin
T9018 17328-17332 NNS denotes mice
T9019 17333-17343 VBG denotes expressing
T9020 17344-17352 JJ denotes inactive
T9021 17353-17357 NNP denotes IKK1
T9022 17358-17362 NN denotes show
T9023 17363-17372 VBD denotes increased
T9024 17373-17383 NN denotes production
T9025 17384-17386 IN denotes of
T9026 17387-17402 JJ denotes proinflammatory
T9027 17403-17412 NNS denotes cytokines
T9028 17413-17415 IN denotes as
T9029 17416-17417 DT denotes a
T9030 17418-17424 NN denotes result
T9031 17425-17427 IN denotes of
T9032 17428-17436 JJ denotes enhanced
T9033 17437-17441 NNP denotes IKK2
T9034 17442-17452 NN denotes activation
T9035 17453-17456 CC denotes and
T9036 17457-17461 NNP denotes IκBα
T9037 17462-17473 NN denotes degradation
T9038 17474-17475 NNP denotes [
T9039 17475-17477 CD denotes 34
T9040 17477-17478 NNP denotes ]
T9041 17478-17479 . denotes .
T9042 17480-17484 CD denotes IKK1
T9043 17485-17488 VBZ denotes has
T9044 17489-17493 RB denotes also
T9045 17494-17498 VBN denotes been
T9046 17499-17504 VBN denotes shown
T9047 17505-17507 TO denotes to
T9048 17508-17515 VB denotes inhibit
T9049 17516-17523 JJ denotes nuclear
T9050 17524-17529 NN denotes NF-κB
T9051 17530-17533 CC denotes and
T9052 17534-17536 TO denotes to
T9053 17537-17549 VB denotes downregulate
T9054 17550-17565 JJ denotes proinflammatory
T9055 17566-17576 NN denotes signalling
T9056 17577-17579 IN denotes by
T9057 17580-17595 VBG denotes phosphorylating
T9058 17596-17601 NNP denotes STAT1
T9059 17602-17603 NNP denotes [
T9060 17603-17605 CD denotes 35
T9061 17605-17606 NNP denotes ]
T9062 17606-17607 . denotes .
T9063 17608-17621 RB denotes Interestingly
T9064 17621-17622 , denotes ,
T9065 17623-17624 DT denotes a
T9066 17625-17631 JJ denotes recent
T9067 17632-17637 NN denotes study
T9068 17638-17641 VBZ denotes has
T9069 17642-17654 VBN denotes demonstrated
T9070 17655-17659 IN denotes that
T9071 17660-17664 CD denotes IKK1
T9072 17665-17679 NNS denotes phosphorylates
T9073 17680-17683 NNP denotes NIK
T9074 17684-17686 IN denotes in
T9075 17687-17695 JJ denotes negative
T9076 17696-17704 NN denotes feedback
T9077 17705-17715 NN denotes regulation
T9078 17716-17718 IN denotes of
T9079 17719-17722 DT denotes the
T9080 17723-17735 JJ denotes noncanonical
T9081 17736-17741 NN denotes NF-κB
T9082 17742-17749 NN denotes pathway
T9083 17750-17751 NNP denotes [
T9084 17751-17753 CD denotes 36
T9085 17753-17754 NNP denotes ]
T9086 17754-17755 , denotes ,
T9087 17756-17766 VBG denotes supporting
T9088 17767-17770 DT denotes the
T9089 17771-17775 NN denotes idea
T9090 17776-17780 WDT denotes that
T9091 17781-17785 NNP denotes IKK1
T9092 17786-17791 VBZ denotes plays
T9093 17792-17801 JJ denotes important
T9094 17802-17807 NNS denotes roles
T9095 17808-17810 IN denotes in
T9096 17811-17822 VBG denotes terminating
T9097 17823-17827 DT denotes both
T9098 17828-17837 JJ denotes canonical
T9099 17838-17841 CC denotes and
T9100 17842-17854 JJ denotes noncanonical
T9101 17855-17860 NN denotes NF-κB
T9102 17861-17869 NNS denotes pathways
T9103 17870-17874 IN denotes with
T9104 17875-17883 JJ denotes possible
T9105 17884-17896 NNS denotes implications
T9106 17897-17900 IN denotes for
T9107 17901-17908 JJ denotes chronic
T9108 17909-17921 JJ denotes inflammatory
T9109 17922-17930 NNS denotes diseases
T9110 17931-17935 IN denotes like
T9111 17936-17938 NNP denotes RA
T9112 17938-17939 . denotes .
T10859 17941-17944 CD denotes A20
T10860 17945-17952 NN denotes protein
T10861 17953-17956 NNP denotes A20
T10862 17957-17958 -LRB- denotes (
T10863 17958-17962 RB denotes also
T10864 17963-17968 VBN denotes known
T10865 17969-17971 IN denotes as
T10866 17972-17979 CD denotes TNFAIP3
T10867 17979-17980 -RRB- denotes )
T10868 17981-17983 VBZ denotes is
T10869 17984-17985 DT denotes a
T10870 17986-18003 JJ denotes ubiquitin-editing
T10871 18004-18011 NN denotes protein
T10872 18012-18016 WDT denotes that
T10873 18017-18027 RB denotes negatively
T10874 18028-18037 VBZ denotes regulates
T10875 18038-18053 JJ denotes NF-κB-dependent
T10876 18054-18058 NN denotes gene
T10877 18059-18069 NN denotes expression
T10878 18070-18072 IN denotes in
T10879 18073-18081 NN denotes response
T10880 18082-18084 TO denotes to
T10881 18085-18094 JJ denotes different
T10882 18095-18112 JJ denotes immune-activating
T10883 18113-18120 NNS denotes stimuli
T10884 18120-18121 , denotes ,
T10885 18122-18131 VBG denotes including
T10886 18132-18135 NNP denotes TNF
T10887 18135-18136 , denotes ,
T10888 18137-18141 NNP denotes IL-1
T10889 18142-18145 CC denotes and
T10890 18146-18154 NNS denotes antigens
T10891 18154-18155 , denotes ,
T10892 18156-18159 CC denotes and
T10893 18160-18163 DT denotes the
T10894 18164-18174 VBG denotes triggering
T10895 18175-18177 IN denotes of
T10896 18178-18182 NNS denotes TLRs
T10897 18183-18186 CC denotes and
T10898 18187-18190 DT denotes the
T10899 18191-18209 JJ denotes nucleotide-binding
T10900 18210-18225 NN denotes oligomerisation
T10901 18226-18243 NN denotes domain-containing
T10902 18244-18245 CD denotes 2
T10903 18246-18254 NN denotes receptor
T10904 18255-18256 -LRB- denotes (
T10905 18256-18264 VBN denotes reviewed
T10906 18265-18267 IN denotes in
T10907 18268-18269 NNP denotes [
T10908 18269-18271 CD denotes 37
T10909 18271-18272 NNP denotes ]
T10910 18272-18273 -RRB- denotes )
T10911 18273-18274 . denotes .
T10912 18275-18278 CD denotes A20
T10913 18279-18281 VBZ denotes is
T10914 18282-18290 VBN denotes believed
T10915 18291-18293 TO denotes to
T10916 18294-18301 VB denotes inhibit
T10917 18302-18307 JJ denotes NF-κB
T10918 18308-18316 NN denotes function
T10919 18317-18319 IN denotes by
T10920 18320-18336 VBG denotes deubiquitinating
T10921 18337-18345 JJ denotes specific
T10922 18346-18351 NN denotes NF-κB
T10923 18352-18362 VBG denotes signalling
T10924 18363-18372 NNS denotes molecules
T10925 18372-18373 , denotes ,
T10926 18374-18378 JJ denotes such
T10927 18379-18381 IN denotes as
T10928 18382-18386 NNP denotes RIP1
T10929 18386-18387 , denotes ,
T10930 18388-18392 NNP denotes RIP2
T10931 18392-18393 , denotes ,
T10932 18394-18399 NNP denotes TRAF6
T10933 18400-18403 CC denotes and
T10934 18404-18409 NNP denotes MALT1
T10935 18409-18410 , denotes ,
T10936 18411-18416 WDT denotes which
T10937 18417-18425 VBZ denotes disrupts
T10938 18426-18434 JJ denotes specific
T10939 18435-18450 NN denotes protein-protein
T10940 18451-18463 NNS denotes interactions
T10941 18464-18465 NNP denotes [
T10942 18465-18470 CD denotes 38-41
T10943 18470-18471 NNP denotes ]
T10944 18472-18473 -LRB- denotes (
T10945 18473-18479 NNP denotes Figure
T10946 18480-18481 CD denotes 1
T10947 18481-18482 -RRB- denotes )
T10948 18482-18483 . denotes .
T10949 18484-18492 RB denotes Recently
T10950 18492-18493 , denotes ,
T10951 18494-18497 DT denotes the
T10952 18498-18508 NN denotes disruption
T10953 18509-18511 IN denotes of
T10954 18512-18524 NNS denotes interactions
T10955 18525-18532 IN denotes between
T10956 18533-18535 CD denotes E2
T10957 18536-18545 NN denotes ubiquitin
T10958 18546-18557 VBG denotes conjugating
T10959 18558-18565 NNS denotes enzymes
T10960 18566-18567 -LRB- denotes (
T10961 18567-18572 JJ denotes Ubc13
T10962 18573-18576 CC denotes and
T10963 18577-18583 JJ denotes Ubc5hc
T10964 18583-18584 -RRB- denotes )
T10965 18585-18588 CC denotes and
T10966 18589-18591 CD denotes E3
T10967 18592-18601 NN denotes ubiquitin
T10968 18602-18609 NNS denotes ligases
T10969 18610-18611 -LRB- denotes (
T10970 18611-18616 CD denotes TRAF6
T10971 18616-18617 , denotes ,
T10972 18618-18623 CD denotes TRAF2
T10973 18624-18627 CC denotes and
T10974 18628-18635 NNP denotes cIAP1/2
T10975 18635-18636 -RRB- denotes )
T10976 18637-18641 VBD denotes were
T10977 18642-18651 VBN denotes described
T10978 18652-18654 IN denotes as
T10979 18655-18662 DT denotes another
T10980 18663-18672 JJ denotes important
T10981 18673-18682 NN denotes mechanism
T10982 18683-18687 VBN denotes used
T10983 18688-18690 IN denotes by
T10984 18691-18694 CD denotes A20
T10985 18695-18697 TO denotes to
T10986 18698-18710 VB denotes downregulate
T10987 18711-18716 JJ denotes NF-κB
T10988 18717-18727 JJ denotes signalling
T10989 18728-18729 NNP denotes [
T10990 18729-18731 CD denotes 42
T10991 18731-18732 NNP denotes ]
T10992 18732-18733 . denotes .
T10993 18734-18737 DT denotes The
T10994 18738-18749 NN denotes association
T10995 18750-18752 IN denotes of
T10996 18753-18756 CD denotes A20
T10997 18757-18761 IN denotes with
T10998 18762-18765 PRP$ denotes its
T10999 18766-18773 NNS denotes targets
T11000 18774-18782 VBZ denotes requires
T11001 18783-18791 JJ denotes specific
T11002 18792-18809 JJ denotes ubiquitin-binding
T11003 18810-18817 NN denotes adaptor
T11004 18818-18826 NNS denotes proteins
T11005 18826-18827 , denotes ,
T11006 18828-18837 VBG denotes including
T11007 18838-18849 JJ denotes A20-binding
T11008 18850-18859 NN denotes inhibitor
T11009 18860-18862 IN denotes of
T11010 18863-18868 NNP denotes NF-κB
T11011 18869-18870 -LRB- denotes (
T11012 18870-18874 NNP denotes ABIN
T11013 18874-18875 -RRB- denotes )
T11014 18876-18877 CD denotes 1
T11015 18878-18881 CC denotes and
T11016 18882-18894 JJ denotes Tax1-binding
T11017 18895-18902 NN denotes protein
T11018 18903-18904 CD denotes 1
T11019 18905-18906 NNP denotes [
T11020 18906-18911 CD denotes 43-46
T11021 18911-18912 NNP denotes ]
T11022 18912-18913 . denotes .
T11023 18914-18918 JJ denotes Next
T11024 18919-18921 TO denotes to
T11025 18922-18925 PRP$ denotes its
T11026 18926-18930 NN denotes role
T11027 18931-18933 IN denotes in
T11028 18934-18945 VBG denotes suppressing
T11029 18946-18951 JJ denotes NF-κB
T11030 18952-18962 NN denotes activation
T11031 18962-18963 , denotes ,
T11032 18964-18967 NNP denotes A20
T11033 18968-18970 VBZ denotes is
T11034 18971-18975 RB denotes also
T11035 18976-18977 DT denotes a
T11036 18978-18984 JJ denotes strong
T11037 18985-18994 NN denotes inhibitor
T11038 18995-18997 IN denotes of
T11039 18998-19007 NN denotes apoptosis
T11040 19007-19008 , denotes ,
T11041 19009-19011 IN denotes at
T11042 19012-19017 JJS denotes least
T11043 19018-19020 IN denotes in
T11044 19021-19025 DT denotes some
T11045 19026-19030 NN denotes cell
T11046 19031-19036 NNS denotes types
T11047 19036-19037 . denotes .
T11048 19038-19041 DT denotes The
T11049 19042-19052 NNS denotes mechanisms
T11050 19053-19055 IN denotes by
T11051 19056-19061 WDT denotes which
T11052 19062-19065 NNP denotes A20
T11053 19066-19075 VBZ denotes regulates
T11054 19076-19085 JJ denotes apoptotic
T11055 19086-19096 NN denotes signalling
T11056 19096-19097 , denotes ,
T11057 19098-19105 RB denotes however
T11058 19105-19106 , denotes ,
T11059 19107-19110 VBP denotes are
T11060 19111-19116 RB denotes still
T11061 19117-19124 JJ denotes elusive
T11062 19124-19125 . denotes .
T11063 19126-19139 JJ denotes A20-deficient
T11064 19140-19144 NNS denotes mice
T11065 19145-19158 RB denotes spontaneously
T11066 19159-19166 VBP denotes develop
T11067 19167-19177 JJ denotes multiorgan
T11068 19178-19190 NN denotes inflammation
T11069 19191-19194 CC denotes and
T11070 19195-19203 NN denotes cachexia
T11071 19204-19207 CC denotes and
T11072 19208-19211 VB denotes die
T11073 19212-19218 IN denotes within
T11074 19219-19220 CD denotes 2
T11075 19221-19226 NNS denotes weeks
T11076 19227-19229 IN denotes of
T11077 19230-19235 NN denotes birth
T11078 19235-19236 , denotes ,
T11079 19237-19249 VBG denotes illustrating
T11080 19250-19253 DT denotes the
T11081 19254-19260 JJ denotes potent
T11082 19261-19278 JJ denotes anti-inflammatory
T11083 19279-19287 NN denotes function
T11084 19288-19290 IN denotes of
T11085 19291-19295 DT denotes this
T11086 19296-19304 NN denotes molecule
T11087 19305-19306 NNP denotes [
T11088 19306-19308 CD denotes 46
T11089 19308-19309 NNP denotes ]
T11090 19309-19310 . denotes .
T11091 19311-19324 JJ denotes A20-deficient
T11092 19325-19330 NNS denotes cells
T11093 19331-19334 VBP denotes are
T11094 19335-19339 RB denotes also
T11095 19340-19344 RBR denotes more
T11096 19345-19356 JJ denotes susceptible
T11097 19357-19359 TO denotes to
T11098 19360-19372 JJ denotes TNF-mediated
T11099 19373-19382 NN denotes apoptosis
T11100 19382-19383 , denotes ,
T11101 19384-19394 VBG denotes confirming
T11102 19395-19398 PRP$ denotes its
T11103 19399-19403 NN denotes role
T11104 19404-19406 IN denotes as
T11105 19407-19409 DT denotes an
T11106 19410-19423 JJ denotes antiapoptotic
T11107 19424-19431 NN denotes protein
T11108 19431-19432 . denotes .
T11109 19433-19435 PRP denotes We
T11110 19436-19444 RB denotes recently
T11111 19445-19451 VBD denotes showed
T11112 19452-19456 IN denotes that
T11113 19457-19461 NNS denotes mice
T11114 19462-19474 RB denotes specifically
T11115 19475-19482 VBG denotes lacking
T11116 19483-19486 NNP denotes A20
T11117 19487-19489 IN denotes in
T11118 19490-19500 JJ denotes intestinal
T11119 19501-19511 JJ denotes epithelial
T11120 19512-19517 NNS denotes cells
T11121 19518-19525 VBP denotes exhibit
T11122 19526-19535 VBN denotes increased
T11123 19536-19550 NN denotes susceptibility
T11124 19551-19553 TO denotes to
T11125 19554-19566 JJ denotes experimental
T11126 19567-19574 NNS denotes colitis
T11127 19575-19578 JJ denotes due
T11128 19579-19581 TO denotes to
T11129 19582-19585 DT denotes the
T11130 19586-19602 NN denotes hypersensitivity
T11131 19603-19605 IN denotes of
T11132 19606-19611 PRP$ denotes their
T11133 19612-19622 JJ denotes intestinal
T11134 19623-19633 JJ denotes epithelial
T11135 19634-19639 NNS denotes cells
T11136 19640-19642 TO denotes to
T11137 19643-19654 JJ denotes TNF-induced
T11138 19655-19664 NN denotes apoptosis
T11139 19664-19665 , denotes ,
T11140 19666-19676 VBG denotes confirming
T11141 19677-19680 NNP denotes A20
T11142 19681-19683 IN denotes as
T11143 19684-19685 DT denotes a
T11144 19686-19691 JJ denotes major
T11145 19692-19705 JJ denotes antiapoptotic
T11146 19706-19713 NN denotes protein
T11147 19714-19716 IN denotes in
T11148 19717-19720 DT denotes the
T11149 19721-19731 JJ denotes intestinal
T11150 19732-19742 NN denotes epithelium
T11151 19743-19744 NNP denotes [
T11152 19744-19746 CD denotes 47
T11153 19746-19747 NNP denotes ]
T11154 19747-19748 . denotes .
T11155 19749-19752 CD denotes Two
T11156 19753-19764 JJ denotes independent
T11157 19765-19772 NNS denotes studies
T11158 19773-19779 VBD denotes showed
T11159 19780-19784 IN denotes that
T11160 19785-19789 NNS denotes mice
T11161 19790-19797 VBG denotes lacking
T11162 19798-19801 NNP denotes A20
T11163 19802-19804 IN denotes in
T11164 19805-19806 NNP denotes B
T11165 19807-19812 NNS denotes cells
T11166 19813-19820 VBP denotes develop
T11167 19821-19833 NN denotes autoimmunity
T11168 19834-19837 JJ denotes due
T11169 19838-19840 TO denotes to
T11170 19841-19852 JJ denotes hyperactive
T11171 19853-19858 NN denotes NF-κB
T11172 19859-19868 NNS denotes responses
T11173 19869-19871 IN denotes in
T11174 19872-19873 NNP denotes B
T11175 19874-19879 NNS denotes cells
T11176 19880-19887 VBG denotes leading
T11177 19888-19890 TO denotes to
T11178 19891-19903 JJ denotes unrestricted
T11179 19904-19910 NN denotes B-cell
T11180 19911-19919 NN denotes survival
T11181 19920-19921 NNP denotes [
T11182 19921-19926 CD denotes 48,49
T11183 19926-19927 NNP denotes ]
T11184 19927-19928 . denotes .
T11185 19929-19932 CD denotes A20
T11186 19933-19943 NN denotes expression
T11187 19944-19947 VBZ denotes has
T11188 19948-19952 VBN denotes been
T11189 19953-19961 VBN denotes observed
T11190 19962-19964 IN denotes in
T11191 19965-19972 JJ denotes several
T11192 19973-19977 NN denotes cell
T11193 19978-19983 NNS denotes types
T11194 19984-19988 WDT denotes that
T11195 19989-19993 VBP denotes play
T11196 19994-20003 JJ denotes important
T11197 20004-20009 NNS denotes roles
T11198 20010-20012 IN denotes in
T11199 20013-20016 DT denotes the
T11200 20017-20032 NN denotes pathophysiology
T11201 20033-20035 IN denotes of
T11202 20036-20038 NNP denotes RA
T11203 20038-20039 , denotes ,
T11204 20040-20044 JJ denotes such
T11205 20045-20047 IN denotes as
T11206 20048-20059 NNS denotes fibroblasts
T11207 20059-20060 , denotes ,
T11208 20061-20073 NNS denotes synoviocytes
T11209 20074-20077 CC denotes and
T11210 20078-20089 NNS denotes lymphocytes
T11211 20089-20090 . denotes .
T11212 20091-20104 RB denotes Interestingly
T11213 20104-20105 , denotes ,
T11214 20106-20109 NNP denotes A20
T11215 20110-20120 NN denotes expression
T11216 20121-20123 VBZ denotes is
T11217 20124-20130 PRP denotes itself
T11218 20131-20140 VBN denotes regulated
T11219 20141-20143 IN denotes by
T11220 20144-20149 NNP denotes NF-κB
T11221 20150-20151 NNP denotes [
T11222 20151-20153 CD denotes 50
T11223 20153-20154 NNP denotes ]
T11224 20154-20155 , denotes ,
T11225 20156-20167 VBG denotes implicating
T11226 20168-20171 NNP denotes A20
T11227 20172-20174 IN denotes in
T11228 20175-20178 DT denotes the
T11229 20179-20187 JJ denotes negative
T11230 20188-20196 NN denotes feedback
T11231 20197-20207 NN denotes regulation
T11232 20208-20210 IN denotes of
T11233 20211-20216 JJ denotes NF-κB
T11234 20217-20227 NN denotes signalling
T11235 20227-20228 . denotes .
T11236 20229-20237 RB denotes Recently
T11237 20237-20238 , denotes ,
T11238 20239-20254 JJ denotes intra-articular
T11239 20255-20264 NN denotes injection
T11240 20265-20267 IN denotes of
T11241 20268-20270 DT denotes an
T11242 20271-20285 JJ denotes A20-expressing
T11243 20286-20296 NN denotes adenovirus
T11244 20297-20300 VBD denotes was
T11245 20301-20306 VBN denotes shown
T11246 20307-20309 TO denotes to
T11247 20310-20316 VB denotes reduce
T11248 20317-20320 DT denotes the
T11249 20321-20329 NN denotes severity
T11250 20330-20332 IN denotes of
T11251 20333-20341 JJ denotes synovial
T11252 20342-20354 NN denotes inflammation
T11253 20355-20358 CC denotes and
T11254 20359-20364 JJ denotes joint
T11255 20365-20376 NN denotes destruction
T11256 20377-20379 IN denotes in
T11257 20380-20381 DT denotes a
T11258 20382-20387 NN denotes mouse
T11259 20388-20393 NN denotes model
T11260 20394-20396 IN denotes of
T11261 20397-20413 JJ denotes collagen-induced
T11262 20414-20423 NNS denotes arthritis
T11263 20423-20424 , denotes ,
T11264 20425-20429 RB denotes even
T11265 20430-20432 IN denotes in
T11266 20433-20442 JJ denotes untreated
T11267 20443-20449 NNS denotes joints
T11268 20449-20450 , denotes ,
T11269 20451-20453 IN denotes in
T11270 20454-20458 DT denotes both
T11271 20459-20460 DT denotes a
T11272 20461-20473 NN denotes prophylactic
T11273 20474-20477 CC denotes and
T11274 20478-20489 JJ denotes therapeutic
T11275 20490-20497 NN denotes setting
T11276 20497-20498 . denotes .
T11277 20499-20502 CD denotes A20
T11278 20503-20513 NN denotes expression
T11279 20514-20516 IN denotes in
T11280 20517-20525 JJ denotes synovial
T11281 20526-20532 NN denotes tissue
T11282 20533-20536 VBD denotes was
T11283 20537-20547 VBN denotes associated
T11284 20548-20552 IN denotes with
T11285 20553-20563 NN denotes inhibition
T11286 20564-20566 IN denotes of
T11287 20567-20572 JJ denotes NF-κB
T11288 20573-20581 NN denotes activity
T11289 20582-20585 CC denotes and
T11290 20586-20595 VBD denotes decreased
T11291 20596-20602 NNS denotes levels
T11292 20603-20605 IN denotes of
T11293 20606-20609 NNP denotes TNF
T11294 20609-20610 , denotes ,
T11295 20611-20616 NNP denotes IL-1β
T11296 20616-20617 , denotes ,
T11297 20618-20622 NNP denotes IL-6
T11298 20622-20623 , denotes ,
T11299 20624-20631 JJ denotes soluble
T11300 20632-20637 NNP denotes RANKL
T11301 20637-20638 , denotes ,
T11302 20639-20647 JJ denotes monocyte
T11303 20648-20664 JJ denotes chemo-attractant
T11304 20665-20672 NN denotes protein
T11305 20673-20674 CD denotes 1
T11306 20674-20675 , denotes ,
T11307 20676-20679 CC denotes and
T11308 20680-20685 NNP denotes IL-17
T11309 20685-20686 , denotes ,
T11310 20687-20697 VBG denotes suggesting
T11311 20698-20702 IN denotes that
T11312 20703-20706 NNP denotes A20
T11313 20707-20714 VBZ denotes induces
T11314 20715-20716 DT denotes a
T11315 20717-20727 JJ denotes protective
T11316 20728-20734 NN denotes effect
T11317 20735-20737 IN denotes in
T11318 20738-20754 JJ denotes collagen-induced
T11319 20755-20764 NNS denotes arthritis
T11320 20765-20769 NNS denotes mice
T11321 20770-20777 IN denotes through
T11322 20778-20789 NN denotes suppression
T11323 20790-20792 IN denotes of
T11324 20793-20798 JJ denotes NF-κB
T11325 20799-20809 NN denotes activation
T11326 20810-20813 CC denotes and
T11327 20814-20816 SYM denotes NF
T11328 20816-20817 : denotes -
T11329 20818-20830 JJ denotes κB-dependent
T11330 20831-20835 NN denotes gene
T11331 20836-20846 NN denotes expression
T11332 20847-20848 NNP denotes [
T11333 20848-20850 CD denotes 51
T11334 20850-20851 NNP denotes ]
T11335 20851-20852 . denotes .
T11336 20853-20860 IN denotes Because
T11337 20861-20864 NNP denotes TNF
T11338 20865-20868 CC denotes and
T11339 20869-20874 NNP denotes IL-1β
T11340 20875-20878 VBP denotes are
T11341 20879-20884 VBN denotes known
T11342 20885-20887 TO denotes to
T11343 20888-20895 VB denotes mediate
T11344 20896-20905 NNS denotes synovitis
T11345 20905-20906 , denotes ,
T11346 20907-20913 NN denotes pannus
T11347 20914-20923 NN denotes formation
T11348 20923-20924 , denotes ,
T11349 20925-20928 CC denotes and
T11350 20929-20936 NN denotes erosion
T11351 20937-20939 IN denotes of
T11352 20940-20949 NN denotes cartilage
T11353 20950-20953 CC denotes and
T11354 20954-20958 NN denotes bone
T11355 20959-20961 IN denotes in
T11356 20962-20964 NNP denotes RA
T11357 20964-20965 , denotes ,
T11358 20966-20969 DT denotes the
T11359 20970-20979 VBN denotes decreased
T11360 20980-20985 NN denotes serum
T11361 20986-20992 NNS denotes levels
T11362 20993-20995 IN denotes of
T11363 20996-20999 NNP denotes TNF
T11364 21000-21003 CC denotes and
T11365 21004-21009 NNP denotes IL-1β
T11366 21010-21012 IN denotes in
T11367 21013-21027 JJ denotes A20-transduced
T11368 21028-21032 NNS denotes mice
T11369 21033-21038 MD denotes might
T11370 21039-21046 VB denotes explain
T11371 21047-21050 DT denotes the
T11372 21051-21061 JJ denotes beneficial
T11373 21062-21069 NNS denotes effects
T11374 21070-21072 IN denotes in
T11375 21073-21076 DT denotes the
T11376 21077-21085 JJ denotes clinical
T11377 21085-21086 , denotes ,
T11378 21087-21099 JJ denotes pathological
T11379 21099-21100 , denotes ,
T11380 21101-21104 CC denotes and
T11381 21105-21117 JJ denotes radiological
T11382 21118-21126 NNS denotes findings
T11383 21126-21127 . denotes .
T11384 21128-21132 DT denotes This
T11385 21133-21138 NN denotes study
T11386 21139-21143 RB denotes also
T11387 21144-21156 VBD denotes demonstrated
T11388 21157-21161 IN denotes that
T11389 21162-21165 CD denotes A20
T11390 21166-21180 NN denotes overexpression
T11391 21181-21186 VBZ denotes leads
T11392 21187-21189 TO denotes to
T11393 21190-21191 DT denotes a
T11394 21192-21200 NN denotes decrease
T11395 21201-21203 IN denotes in
T11396 21204-21207 DT denotes the
T11397 21208-21214 NN denotes number
T11398 21215-21217 IN denotes of
T11399 21218-21227 VBN denotes activated
T11400 21228-21239 NNS denotes osteoclasts
T11401 21240-21242 IN denotes in
T11402 21243-21248 JJ denotes joint
T11403 21249-21255 NN denotes tissue
T11404 21255-21256 . denotes .
T11405 21257-21260 RB denotes A20
T11406 21261-21266 MD denotes might
T11407 21267-21276 RB denotes therefore
T11408 21277-21285 VB denotes minimise
T11409 21286-21291 JJ denotes joint
T11410 21292-21303 NN denotes destruction
T11411 21304-21311 IN denotes through
T11412 21312-21322 VBG denotes decreasing
T11413 21323-21326 DT denotes the
T11414 21327-21337 JJ denotes osteoclast
T11415 21338-21344 NN denotes number
T11416 21345-21348 CC denotes and
T11417 21349-21357 NN denotes activity
T11418 21357-21358 . denotes .
T11419 21359-21361 PRP denotes It
T11420 21362-21366 MD denotes will
T11421 21367-21369 VB denotes be
T11422 21370-21381 JJ denotes interesting
T11423 21382-21384 TO denotes to
T11424 21385-21392 VB denotes analyse
T11425 21393-21395 IN denotes in
T11426 21396-21402 JJ denotes future
T11427 21403-21406 DT denotes the
T11428 21407-21421 NN denotes susceptibility
T11429 21422-21424 IN denotes of
T11430 21425-21436 JJ denotes conditional
T11431 21437-21445 NN denotes knockout
T11432 21446-21450 NNS denotes mice
T11433 21451-21455 WDT denotes that
T11434 21456-21460 VBP denotes lack
T11435 21461-21464 CD denotes A20
T11436 21465-21467 IN denotes in
T11437 21468-21476 JJ denotes specific
T11438 21477-21481 NN denotes cell
T11439 21482-21487 NNS denotes types
T11440 21488-21492 JJ denotes such
T11441 21493-21495 IN denotes as
T11442 21496-21504 JJ denotes synovial
T11443 21505-21516 NNS denotes fibroblasts
T11444 21516-21517 , denotes ,
T11445 21518-21529 NNS denotes macrophages
T11446 21529-21530 , denotes ,
T11447 21531-21540 JJ denotes dendritic
T11448 21541-21546 NNS denotes cells
T11449 21546-21547 , denotes ,
T11450 21548-21549 NNP denotes B
T11451 21550-21555 NNS denotes cells
T11452 21556-21558 CC denotes or
T11453 21559-21560 NN denotes T
T11454 21561-21566 NNS denotes cells
T11455 21566-21567 . denotes .
T11456 21568-21579 RB denotes Importantly
T11457 21579-21580 , denotes ,
T11458 21581-21588 JJ denotes several
T11459 21589-21593 NNS denotes SNPs
T11460 21594-21596 IN denotes in
T11461 21597-21600 DT denotes the
T11462 21601-21606 JJ denotes human
T11463 21607-21610 NNP denotes A20
T11464 21611-21616 NN denotes locus
T11465 21617-21621 VBP denotes have
T11466 21622-21626 VBN denotes been
T11467 21627-21637 VBN denotes associated
T11468 21638-21642 IN denotes with
T11469 21643-21652 VBN denotes increased
T11470 21653-21667 NN denotes susceptibility
T11471 21668-21670 TO denotes to
T11472 21671-21682 NN denotes development
T11473 21683-21685 IN denotes of
T11474 21686-21696 JJ denotes autoimmune
T11475 21697-21708 NNS denotes pathologies
T11476 21709-21710 -LRB- denotes (
T11477 21710-21718 VBN denotes reviewed
T11478 21719-21721 IN denotes in
T11479 21722-21723 NNP denotes [
T11480 21723-21725 CD denotes 52
T11481 21725-21726 NNP denotes ]
T11482 21726-21727 -RRB- denotes )
T11483 21727-21728 . denotes .
T11484 21729-21736 JJ denotes Several
T11485 21737-21748 JJ denotes genome-wide
T11486 21749-21760 NN denotes association
T11487 21761-21768 NNS denotes studies
T11488 21769-21773 RB denotes also
T11489 21774-21782 VBD denotes revealed
T11490 21783-21784 DT denotes a
T11491 21785-21790 JJ denotes clear
T11492 21791-21802 NN denotes association
T11493 21803-21810 IN denotes between
T11494 21811-21820 NNS denotes mutations
T11495 21821-21823 IN denotes in
T11496 21824-21827 DT denotes the
T11497 21828-21831 NNP denotes A20
T11498 21832-21837 NN denotes locus
T11499 21838-21840 IN denotes in
T11500 21841-21844 DT denotes the
T11501 21845-21849 JJ denotes 6q23
T11502 21850-21860 NN denotes chromosome
T11503 21861-21864 CC denotes and
T11504 21865-21879 NN denotes susceptibility
T11505 21880-21882 TO denotes to
T11506 21883-21885 NNP denotes RA
T11507 21886-21887 NNP denotes [
T11508 21887-21889 CD denotes 52
T11509 21889-21890 NNP denotes ]
T11510 21890-21891 . denotes .
T11511 21892-21900 IN denotes Although
T11512 21901-21904 DT denotes the
T11513 21905-21915 VBN denotes identified
T11514 21916-21924 NNS denotes variants
T11515 21925-21928 VBP denotes are
T11516 21929-21932 RB denotes not
T11517 21933-21940 VBN denotes located
T11518 21941-21943 IN denotes in
T11519 21944-21945 DT denotes a
T11520 21946-21950 NN denotes gene
T11521 21950-21951 , denotes ,
T11522 21952-21956 PRP denotes they
T11523 21957-21960 VBP denotes are
T11524 21961-21968 VBN denotes thought
T11525 21969-21971 TO denotes to
T11526 21972-21981 VB denotes influence
T11527 21982-21985 NNP denotes A20
T11528 21986-21988 IN denotes as
T11529 21989-21992 PRP$ denotes its
T11530 21993-22000 JJS denotes nearest
T11531 22001-22005 NN denotes gene
T11532 22006-22007 -LRB- denotes (
T11533 22007-22008 FW denotes ~
T11534 22008-22011 CD denotes 150
T11535 22012-22014 NN denotes kb
T11536 22015-22025 JJ denotes downstream
T11537 22026-22028 IN denotes of
T11538 22029-22032 NNP denotes A20
T11539 22032-22033 -RRB- denotes )
T11540 22033-22034 , denotes ,
T11541 22035-22043 RB denotes probably
T11542 22044-22046 IN denotes by
T11543 22047-22050 DT denotes the
T11544 22051-22059 NN denotes presence
T11545 22060-22062 IN denotes of
T11546 22063-22072 JJ denotes potential
T11547 22073-22083 JJ denotes regulatory
T11548 22084-22087 NN denotes DNA
T11549 22088-22096 NNS denotes elements
T11550 22097-22099 IN denotes in
T11551 22100-22104 DT denotes this
T11552 22105-22111 NN denotes region
T11553 22111-22112 . denotes .
T11554 22113-22115 IN denotes As
T11555 22116-22119 NNP denotes A20
T11556 22120-22122 VBZ denotes is
T11557 22123-22131 VBN denotes required
T11558 22132-22135 IN denotes for
T11559 22136-22147 NN denotes termination
T11560 22148-22150 IN denotes of
T11561 22151-22162 JJ denotes TNF-induced
T11562 22163-22170 NNS denotes signals
T11563 22170-22171 , denotes ,
T11564 22172-22175 CC denotes and
T11565 22176-22179 NNP denotes TNF
T11566 22180-22182 VBZ denotes is
T11567 22183-22186 DT denotes the
T11568 22187-22194 JJ denotes primary
T11569 22195-22207 JJ denotes inflammatory
T11570 22208-22216 NN denotes cytokine
T11571 22217-22219 IN denotes in
T11572 22220-22222 NNP denotes RA
T11573 22222-22223 , denotes ,
T11574 22224-22229 DT denotes these
T11575 22230-22238 NNS denotes findings
T11576 22239-22245 VBP denotes reveal
T11577 22246-22249 NNP denotes A20
T11578 22250-22252 IN denotes as
T11579 22253-22254 DT denotes a
T11580 22255-22264 NN denotes candidate
T11581 22265-22279 NN denotes susceptibility
T11582 22280-22285 NN denotes locus
T11583 22286-22289 IN denotes for
T11584 22290-22292 NNP denotes RA
T11585 22292-22293 . denotes .
T11586 22294-22297 WRB denotes How
T11587 22298-22303 DT denotes these
T11588 22304-22312 NNS denotes variants
T11589 22313-22319 VBP denotes affect
T11590 22320-22326 JJ denotes normal
T11591 22327-22330 JJ denotes A20
T11592 22331-22339 NN denotes activity
T11593 22340-22343 CC denotes and
T11594 22344-22347 WRB denotes how
T11595 22348-22352 PRP denotes they
T11596 22353-22358 VBP denotes cause
T11597 22359-22361 NNP denotes RA
T11598 22361-22362 , denotes ,
T11599 22363-22370 RB denotes however
T11600 22370-22371 , denotes ,
T11601 22372-22378 VBP denotes remain
T11602 22379-22386 JJ denotes unclear
T11603 22386-22387 . denotes .
T11604 22388-22396 RB denotes Recently
T11605 22396-22397 , denotes ,
T11606 22398-22403 NNP denotes Elsby
T11607 22404-22407 CC denotes and
T11608 22408-22418 NNS denotes colleagues
T11609 22419-22431 RB denotes functionally
T11610 22432-22441 VBN denotes evaluated
T11611 22442-22444 IN denotes in
T11612 22445-22450 NN denotes vitro
T11613 22451-22454 DT denotes the
T11614 22455-22465 JJ denotes regulatory
T11615 22466-22473 NN denotes ability
T11616 22474-22476 IN denotes of
T11617 22477-22490 JJ denotes RA-associated
T11618 22491-22494 NNP denotes SNP
T11619 22495-22503 NNS denotes variants
T11620 22504-22506 IN denotes on
T11621 22507-22510 NNP denotes A20
T11622 22511-22519 NN denotes promoter
T11623 22520-22528 NN denotes activity
T11624 22528-22529 , denotes ,
T11625 22530-22533 CC denotes and
T11626 22534-22539 MD denotes could
T11627 22540-22544 VB denotes show
T11628 22545-22554 JJ denotes repressed
T11629 22555-22558 NNP denotes A20
T11630 22559-22572 NN denotes transcription
T11631 22573-22576 IN denotes for
T11632 22577-22581 DT denotes some
T11633 22582-22584 IN denotes of
T11634 22585-22588 DT denotes the
T11635 22589-22593 NNS denotes SNPs
T11636 22594-22606 VBD denotes investigated
T11637 22607-22608 NNP denotes [
T11638 22608-22610 CD denotes 53
T11639 22610-22611 NNP denotes ]
T11640 22611-22612 . denotes .
T11641 22613-22615 PRP denotes It
T11642 22616-22620 MD denotes will
T11643 22621-22623 VB denotes be
T11644 22624-22626 IN denotes of
T11645 22627-22635 NN denotes interest
T11646 22636-22638 TO denotes to
T11647 22639-22647 VB denotes identify
T11648 22648-22651 DT denotes the
T11649 22652-22658 JJ denotes actual
T11650 22659-22665 JJ denotes causal
T11651 22666-22674 NNS denotes variants
T11652 22675-22678 CC denotes and
T11653 22679-22681 TO denotes to
T11654 22682-22691 VB denotes elucidate
T11655 22692-22695 DT denotes the
T11656 22696-22706 JJ denotes functional
T11657 22707-22719 NNS denotes consequences
T11658 22720-22722 IN denotes of
T11659 22723-22728 DT denotes these
T11660 22729-22737 NNS denotes variants
T11661 22737-22738 . denotes .
T11662 22739-22741 IN denotes In
T11663 22742-22746 DT denotes this
T11664 22747-22754 NN denotes context
T11665 22754-22755 , denotes ,
T11666 22756-22763 FW denotes knockin
T11667 22764-22768 NNS denotes mice
T11668 22769-22772 IN denotes for
T11669 22773-22776 DT denotes the
T11670 22777-22790 JJ denotes corresponding
T11671 22791-22794 NNP denotes A20
T11672 22795-22799 NNS denotes SNPs
T11673 22799-22800 , denotes ,
T11674 22801-22809 VBN denotes combined
T11675 22810-22814 IN denotes with
T11676 22815-22820 NN denotes mouse
T11677 22821-22827 NNS denotes models
T11678 22828-22831 IN denotes for
T11679 22832-22834 NNP denotes RA
T11680 22834-22835 , denotes ,
T11681 22836-22840 MD denotes will
T11682 22841-22843 VB denotes be
T11683 22844-22848 RB denotes very
T11684 22849-22857 JJ denotes valuable
T11685 22858-22863 NNS denotes tools
T11686 22863-22864 . denotes .
T13214 22866-22877 JJ denotes A20-binding
T13215 22878-22888 NNS denotes inhibitors
T13216 22889-22891 IN denotes of
T13217 22892-22897 NNP denotes NF-κB
T13218 22898-22904 NNP denotes ABIN-1
T13219 22904-22905 , denotes ,
T13220 22906-22912 NNP denotes ABIN-2
T13221 22913-22916 CC denotes and
T13222 22917-22923 NNP denotes ABIN-3
T13223 22924-22925 -LRB- denotes (
T13224 22925-22929 RB denotes also
T13225 22930-22935 VBN denotes known
T13226 22936-22938 IN denotes as
T13227 22939-22945 CD denotes TNIP-1
T13228 22945-22946 , denotes ,
T13229 22947-22953 CD denotes TNIP-2
T13230 22953-22954 , denotes ,
T13231 22955-22958 CC denotes and
T13232 22959-22965 NNP denotes TNIP-3
T13233 22965-22966 -RRB- denotes )
T13234 22967-22971 VBD denotes were
T13235 22972-22982 VBN denotes identified
T13236 22983-22985 IN denotes as
T13237 22986-22998 RB denotes ubiquitously
T13238 22999-23008 VBN denotes expressed
T13239 23009-23012 NNP denotes A20
T13240 23013-23024 VBG denotes interacting
T13241 23025-23033 NNS denotes proteins
T13242 23034-23037 CC denotes and
T13243 23038-23042 VBD denotes were
T13244 23043-23048 VBN denotes shown
T13245 23049-23051 TO denotes to
T13246 23052-23059 VB denotes inhibit
T13247 23060-23065 JJ denotes NF-κB
T13248 23066-23076 NN denotes activation
T13249 23077-23079 IN denotes by
T13250 23080-23083 NNP denotes TNF
T13251 23084-23087 CC denotes and
T13252 23088-23095 JJ denotes several
T13253 23096-23101 JJ denotes other
T13254 23102-23114 JJ denotes inflammatory
T13255 23115-23122 NNS denotes stimuli
T13256 23123-23127 IN denotes upon
T13257 23128-23142 NN denotes overexpression
T13258 23142-23143 . denotes .
T13259 23144-23151 IN denotes Because
T13260 23152-23157 NNP denotes ABINs
T13261 23158-23165 VBP denotes contain
T13262 23166-23167 DT denotes a
T13263 23168-23176 JJ denotes specific
T13264 23177-23194 JJ denotes ubiquitin-binding
T13265 23195-23200 NN denotes motif
T13266 23200-23201 , denotes ,
T13267 23202-23206 PRP denotes they
T13268 23207-23211 VBP denotes have
T13269 23212-23216 VBN denotes been
T13270 23217-23225 VBN denotes proposed
T13271 23226-23228 TO denotes to
T13272 23229-23235 VB denotes target
T13273 23236-23239 CD denotes A20
T13274 23240-23242 TO denotes to
T13275 23243-23260 VBN denotes polyubiquitinated
T13276 23261-23271 NNS denotes substrates
T13277 23272-23273 NNP denotes [
T13278 23273-23278 CD denotes 43,44
T13279 23278-23279 NNP denotes ]
T13280 23279-23280 . denotes .
T13281 23281-23288 JJ denotes Similar
T13282 23289-23291 TO denotes to
T13283 23292-23295 NNP denotes A20
T13284 23295-23296 , denotes ,
T13285 23297-23303 NNP denotes ABIN-1
T13286 23304-23307 CC denotes and
T13287 23308-23314 NNP denotes ABIN-3
T13288 23315-23325 NN denotes expression
T13289 23326-23328 VBZ denotes is
T13290 23329-23334 JJ denotes NF-κB
T13291 23335-23344 JJ denotes dependent
T13292 23344-23345 , denotes ,
T13293 23346-23357 VBG denotes implicating
T13294 23358-23359 DT denotes a
T13295 23360-23369 JJ denotes potential
T13296 23370-23374 NN denotes role
T13297 23375-23378 IN denotes for
T13298 23379-23382 DT denotes the
T13299 23383-23391 NNP denotes A20/ABIN
T13300 23392-23399 NN denotes complex
T13301 23400-23402 IN denotes in
T13302 23403-23406 DT denotes the
T13303 23407-23415 JJ denotes negative
T13304 23416-23424 NN denotes feedback
T13305 23425-23435 NN denotes regulation
T13306 23436-23438 IN denotes of
T13307 23439-23444 JJ denotes NF-κB
T13308 23445-23455 NN denotes activation
T13309 23456-23457 -LRB- denotes (
T13310 23457-23465 VBN denotes reviewed
T13311 23466-23468 IN denotes in
T13312 23469-23470 NNP denotes [
T13313 23470-23472 CD denotes 54
T13314 23472-23473 NNP denotes ]
T13315 23473-23474 -RRB- denotes )
T13316 23474-23475 . denotes .
T13317 23476-23488 RB denotes Unexpectedly
T13318 23488-23489 , denotes ,
T13319 23490-23494 DT denotes both
T13320 23495-23511 JJ denotes ABIN-1-deficient
T13321 23512-23515 CC denotes and
T13322 23516-23532 JJ denotes ABIN-2-deficient
T13323 23533-23537 NNS denotes mice
T13324 23538-23545 VBP denotes exhibit
T13325 23546-23550 RB denotes only
T13326 23551-23559 RB denotes slightly
T13327 23560-23569 VBN denotes increased
T13328 23570-23572 CC denotes or
T13329 23573-23579 JJ denotes normal
T13330 23580-23585 NN denotes NF-κB
T13331 23586-23595 NNS denotes responses
T13332 23595-23596 , denotes ,
T13333 23597-23609 RB denotes respectively
T13334 23609-23610 , denotes ,
T13335 23611-23619 RB denotes possibly
T13336 23620-23630 VBG denotes reflecting
T13337 23631-23640 JJ denotes redundant
T13338 23641-23646 NN denotes NF-κB
T13339 23647-23657 NN denotes inhibitory
T13340 23658-23668 NNS denotes activities
T13341 23669-23671 IN denotes of
T13342 23672-23680 JJ denotes multiple
T13343 23681-23686 NNP denotes ABINs
T13344 23687-23688 NNP denotes [
T13345 23688-23693 CD denotes 55,56
T13346 23693-23694 NNP denotes ]
T13347 23694-23695 . denotes .
T13348 23696-23706 NNP denotes Functional
T13349 23707-23713 NNP denotes ABIN-3
T13350 23714-23716 VBZ denotes is
T13351 23717-23726 VBN denotes expressed
T13352 23727-23729 IN denotes in
T13353 23730-23736 NNS denotes humans
T13354 23736-23737 , denotes ,
T13355 23738-23741 CC denotes but
T13356 23742-23746 NNS denotes mice
T13357 23747-23751 RB denotes only
T13358 23752-23759 VB denotes express
T13359 23760-23761 DT denotes a
T13360 23762-23771 VBN denotes truncated
T13361 23772-23775 CC denotes and
T13362 23776-23784 JJ denotes inactive
T13363 23785-23789 NN denotes form
T13364 23790-23797 VBG denotes lacking
T13365 23798-23801 DT denotes the
T13366 23802-23809 JJ denotes crucial
T13367 23810-23827 JJ denotes ubiquitin-binding
T13368 23828-23834 NN denotes domain
T13369 23835-23836 NNP denotes [
T13370 23836-23838 CD denotes 57
T13371 23838-23839 NNP denotes ]
T13372 23839-23840 . denotes .
T13373 23841-23843 IN denotes As
T13374 23844-23847 IN denotes for
T13375 23848-23851 NNP denotes A20
T13376 23851-23852 , denotes ,
T13377 23853-23859 NNP denotes ABIN-1
T13378 23860-23864 RB denotes also
T13379 23865-23873 RB denotes strongly
T13380 23874-23882 VBZ denotes inhibits
T13381 23883-23894 JJ denotes TNF-induced
T13382 23895-23904 NN denotes apoptosis
T13383 23905-23906 NNP denotes [
T13384 23906-23908 CD denotes 58
T13385 23908-23909 NNP denotes ]
T13386 23909-23910 , denotes ,
T13387 23911-23914 CC denotes and
T13388 23915-23921 NNP denotes ABIN-1
T13389 23922-23931 JJ denotes deficient
T13390 23932-23936 NNS denotes mice
T13391 23937-23940 VBP denotes die
T13392 23941-23954 RB denotes embryonically
T13393 23955-23958 JJ denotes due
T13394 23959-23961 TO denotes to
T13395 23962-23975 JJ denotes TNF-dependent
T13396 23976-23982 JJ denotes foetal
T13397 23983-23988 NN denotes liver
T13398 23989-23998 NN denotes apoptosis
T13399 23999-24000 NNP denotes [
T13400 24000-24002 CD denotes 56
T13401 24002-24003 NNP denotes ]
T13402 24003-24004 . denotes .
T13403 24005-24010 VBG denotes Using
T13404 24011-24026 NN denotes oligonucleotide
T13405 24027-24037 NN denotes microarray
T13406 24038-24046 NN denotes analysis
T13407 24046-24047 , denotes ,
T13408 24048-24054 NN denotes ABIN-1
T13409 24055-24058 VBD denotes was
T13410 24059-24069 VBN denotes identified
T13411 24070-24075 IN denotes among
T13412 24076-24087 JJ denotes TNF-induced
T13413 24088-24093 NNS denotes genes
T13414 24094-24096 IN denotes in
T13415 24097-24102 JJ denotes human
T13416 24103-24115 NNS denotes synoviocytes
T13417 24115-24116 , denotes ,
T13418 24117-24120 CC denotes and
T13419 24121-24125 JJ denotes high
T13420 24126-24132 NNS denotes levels
T13421 24133-24135 IN denotes of
T13422 24136-24142 NNP denotes ABIN-1
T13423 24143-24147 NNP denotes mRNA
T13424 24148-24152 VBD denotes were
T13425 24153-24161 VBN denotes detected
T13426 24162-24164 IN denotes in
T13427 24165-24167 NNP denotes RA
T13428 24168-24174 NN denotes tissue
T13429 24175-24183 NNS denotes biopsies
T13430 24183-24184 , denotes ,
T13431 24185-24195 VBG denotes indicating
T13432 24196-24197 DT denotes a
T13433 24198-24207 JJ denotes potential
T13434 24208-24212 NN denotes role
T13435 24213-24216 IN denotes for
T13436 24217-24223 NNP denotes ABIN-1
T13437 24223-24224 , denotes ,
T13438 24225-24233 RB denotes together
T13439 24234-24238 IN denotes with
T13440 24239-24242 NNP denotes A20
T13441 24242-24243 , denotes ,
T13442 24244-24246 IN denotes in
T13443 24247-24250 DT denotes the
T13444 24251-24259 JJ denotes negative
T13445 24260-24268 NN denotes feedback
T13446 24269-24279 NN denotes regulation
T13447 24280-24282 IN denotes of
T13448 24283-24288 JJ denotes NF-κB
T13449 24289-24299 NN denotes signalling
T13450 24300-24303 CC denotes and
T13451 24304-24307 DT denotes the
T13452 24308-24320 NN denotes pathogenesis
T13453 24321-24323 IN denotes of
T13454 24324-24326 NNP denotes RA
T13455 24327-24328 NNP denotes [
T13456 24328-24330 CD denotes 59
T13457 24330-24331 NNP denotes ]
T13458 24331-24332 . denotes .
T13459 24333-24335 IN denotes In
T13460 24336-24337 DT denotes a
T13461 24338-24344 JJ denotes recent
T13462 24345-24350 NN denotes study
T13463 24350-24351 , denotes ,
T13464 24352-24362 NN denotes inhibition
T13465 24363-24365 IN denotes of
T13466 24366-24369 NNP denotes TLR
T13467 24370-24379 NNS denotes responses
T13468 24380-24382 IN denotes by
T13469 24383-24397 JJ denotes immunoreceptor
T13470 24398-24412 JJ denotes tyrosine-based
T13471 24413-24423 NN denotes activation
T13472 24424-24429 NN denotes motif
T13473 24430-24431 -LRB- denotes (
T13474 24431-24435 NNP denotes ITAM
T13475 24435-24436 -RRB- denotes )
T13476 24436-24437 : denotes -
T13477 24437-24444 VBN denotes coupled
T13478 24445-24454 NNS denotes receptors
T13479 24455-24458 VBD denotes was
T13480 24459-24464 VBN denotes shown
T13481 24465-24467 TO denotes to
T13482 24468-24474 VB denotes depend
T13483 24475-24477 IN denotes on
T13484 24478-24481 DT denotes the
T13485 24482-24492 NN denotes expression
T13486 24493-24495 IN denotes of
T13487 24496-24499 DT denotes the
T13488 24500-24505 JJ denotes NF-κB
T13489 24506-24516 NN denotes inhibitory
T13490 24517-24525 NNS denotes proteins
T13491 24526-24532 JJ denotes ABIN-3
T13492 24533-24536 CC denotes and
T13493 24537-24540 NNP denotes A20
T13494 24540-24541 . denotes .
T13495 24542-24550 RB denotes Moreover
T13496 24550-24551 , denotes ,
T13497 24552-24556 DT denotes this
T13498 24557-24567 JJ denotes protective
T13499 24568-24574 NN denotes effect
T13500 24575-24577 IN denotes of
T13501 24578-24581 DT denotes the
T13502 24582-24586 NNP denotes ITAM
T13503 24587-24590 VBD denotes was
T13504 24591-24599 RB denotes strongly
T13505 24600-24610 VBN denotes suppressed
T13506 24611-24613 IN denotes in
T13507 24614-24626 JJ denotes inflammatory
T13508 24627-24636 NNS denotes arthritis
T13509 24637-24645 JJ denotes synovial
T13510 24646-24657 NNS denotes macrophages
T13511 24658-24659 NNP denotes [
T13512 24659-24661 CD denotes 60
T13513 24661-24662 NNP denotes ]
T13514 24662-24663 . denotes .
T13515 24664-24677 RB denotes Interestingly
T13516 24677-24678 , denotes ,
T13517 24679-24685 JJ denotes ABIN-1
T13518 24686-24699 NNS denotes polymorphisms
T13519 24700-24704 VBP denotes have
T13520 24705-24709 VBN denotes been
T13521 24710-24720 VBN denotes associated
T13522 24721-24725 IN denotes with
T13523 24726-24735 NN denotes psoriasis
T13524 24736-24739 CC denotes and
T13525 24740-24748 JJ denotes systemic
T13526 24749-24754 NN denotes lupus
T13527 24755-24768 VBZ denotes erythematosus
T13528 24769-24771 IN denotes in
T13529 24772-24778 NNS denotes humans
T13530 24779-24780 NNP denotes [
T13531 24780-24785 CD denotes 61,62
T13532 24785-24786 NNP denotes ]
T13533 24786-24787 . denotes .
T13534 24788-24789 DT denotes A
T13535 24790-24794 JJ denotes high
T13536 24795-24801 NN denotes degree
T13537 24802-24804 IN denotes of
T13538 24805-24812 VBP denotes overlap
T13539 24813-24820 IN denotes between
T13540 24821-24829 JJ denotes systemic
T13541 24830-24835 NN denotes lupus
T13542 24836-24849 NNS denotes erythematosus
T13543 24850-24853 CC denotes and
T13544 24854-24856 NNP denotes RA
T13545 24857-24871 NN denotes susceptibility
T13546 24872-24876 NN denotes loci
T13547 24877-24882 MD denotes might
T13548 24883-24885 VB denotes be
T13549 24886-24894 VBN denotes expected
T13550 24895-24897 IN denotes as
T13551 24898-24901 DT denotes the
T13552 24902-24905 CD denotes two
T13553 24906-24914 NNS denotes diseases
T13554 24915-24919 VBP denotes show
T13555 24920-24924 DT denotes some
T13556 24925-24933 JJ denotes clinical
T13557 24934-24941 VBP denotes overlap
T13558 24942-24944 IN denotes in
T13559 24945-24950 JJ denotes joint
T13560 24951-24962 NN denotes involvement
T13561 24962-24963 , denotes ,
T13562 24964-24976 JJ denotes autoantibody
T13563 24977-24987 NN denotes production
T13564 24987-24988 , denotes ,
T13565 24989-24997 JJ denotes systemic
T13566 24998-25006 NNS denotes features
T13567 25007-25010 CC denotes and
T13568 25011-25019 NN denotes response
T13569 25020-25022 TO denotes to
T13570 25023-25033 NNS denotes treatments
T13571 25034-25038 JJ denotes such
T13572 25039-25041 IN denotes as
T13573 25042-25048 NNP denotes B-cell
T13574 25049-25058 NN denotes depletion
T13575 25059-25060 -LRB- denotes (
T13576 25060-25069 NN denotes rituximab
T13577 25069-25070 -RRB- denotes )
T13578 25070-25071 . denotes .
T13579 25072-25074 PRP denotes It
T13580 25075-25079 MD denotes will
T13581 25080-25089 RB denotes therefore
T13582 25090-25092 VB denotes be
T13583 25093-25104 JJ denotes interesting
T13584 25105-25107 TO denotes to
T13585 25108-25119 VB denotes investigate
T13586 25120-25127 IN denotes whether
T13587 25128-25132 NNS denotes SNPs
T13588 25133-25137 WDT denotes that
T13589 25138-25142 VBP denotes have
T13590 25143-25147 VBN denotes been
T13591 25148-25156 VBN denotes reported
T13592 25157-25159 TO denotes to
T13593 25160-25162 VB denotes be
T13594 25163-25173 VBN denotes associated
T13595 25174-25178 IN denotes with
T13596 25179-25187 JJ denotes systemic
T13597 25188-25193 NN denotes lupus
T13598 25194-25207 NNS denotes erythematosus
T13599 25208-25211 VBP denotes are
T13600 25212-25216 RB denotes also
T13601 25217-25227 VBN denotes associated
T13602 25228-25232 IN denotes with
T13603 25233-25235 NNP denotes RA
T13604 25235-25236 . denotes .
T14673 25238-25253 NNP denotes Cylindromatosis
T14674 25254-25261 NN denotes protein
T14675 25262-25277 NNP denotes Cylindromatosis
T14676 25278-25279 -LRB- denotes (
T14677 25279-25283 NNP denotes CYLD
T14678 25283-25284 -RRB- denotes )
T14679 25285-25292 NN denotes protein
T14680 25293-25296 VBD denotes was
T14681 25297-25307 RB denotes originally
T14682 25308-25318 VBN denotes identified
T14683 25319-25321 IN denotes as
T14684 25322-25323 DT denotes a
T14685 25324-25330 NN denotes tumour
T14686 25331-25341 NN denotes suppressor
T14687 25342-25350 VBN denotes involved
T14688 25351-25353 IN denotes in
T14689 25354-25362 JJ denotes familial
T14690 25363-25378 NN denotes cylindromatosis
T14691 25379-25380 NNP denotes [
T14692 25380-25382 CD denotes 63
T14693 25382-25383 NNP denotes ]
T14694 25383-25384 . denotes .
T14695 25385-25389 NNP denotes CYLD
T14696 25390-25392 VBZ denotes is
T14697 25393-25397 RB denotes also
T14698 25398-25406 VBN denotes involved
T14699 25406-25407 , denotes ,
T14700 25408-25415 RB denotes however
T14701 25415-25416 , denotes ,
T14702 25417-25419 IN denotes in
T14703 25420-25427 JJ denotes diverse
T14704 25428-25441 JJ denotes physiological
T14705 25442-25451 NNS denotes processes
T14706 25452-25459 VBG denotes ranging
T14707 25460-25464 IN denotes from
T14708 25465-25473 NN denotes immunity
T14709 25474-25477 CC denotes and
T14710 25478-25490 NN denotes inflammation
T14711 25491-25493 TO denotes to
T14712 25494-25498 NN denotes cell
T14713 25499-25504 NN denotes cycle
T14714 25505-25516 NN denotes progression
T14715 25516-25517 , denotes ,
T14716 25518-25533 NN denotes spermatogenesis
T14717 25533-25534 , denotes ,
T14718 25535-25538 CC denotes and
T14719 25539-25557 NN denotes osteoclastogenesis
T14720 25558-25559 -LRB- denotes (
T14721 25559-25567 VBN denotes reviewed
T14722 25568-25570 IN denotes in
T14723 25571-25572 NNP denotes [
T14724 25572-25574 CD denotes 64
T14725 25574-25575 NNP denotes ]
T14726 25575-25576 -RRB- denotes )
T14727 25576-25577 . denotes .
T14728 25578-25582 NNP denotes CYLD
T14729 25583-25585 VBZ denotes is
T14730 25586-25587 DT denotes a
T14731 25588-25604 VBG denotes deubiquitinating
T14732 25605-25611 NN denotes enzyme
T14733 25612-25616 IN denotes that
T14734 25617-25627 RB denotes negatively
T14735 25628-25637 VBZ denotes regulates
T14736 25638-25643 JJ denotes NF-κB
T14737 25644-25654 VBG denotes signalling
T14738 25655-25664 VBN denotes initiated
T14739 25665-25667 IN denotes by
T14740 25668-25672 NNP denotes TNFR
T14741 25672-25673 , denotes ,
T14742 25674-25678 NNP denotes RANK
T14743 25679-25682 CC denotes and
T14744 25683-25689 NNP denotes T-cell
T14745 25690-25698 NN denotes receptor
T14746 25699-25710 NN denotes stimulation
T14747 25711-25712 -LRB- denotes (
T14748 25712-25720 VBN denotes reviewed
T14749 25721-25723 IN denotes in
T14750 25724-25725 NNP denotes [
T14751 25725-25727 CD denotes 64
T14752 25727-25728 NNP denotes ]
T14753 25728-25729 -RRB- denotes )
T14754 25730-25731 -LRB- denotes (
T14755 25731-25737 NN denotes Figure
T14756 25738-25739 CD denotes 1
T14757 25739-25740 -RRB- denotes )
T14758 25740-25741 , denotes ,
T14759 25742-25744 IN denotes by
T14760 25745-25762 JJ denotes deubiquitina-ting
T14761 25763-25770 JJ denotes several
T14762 25771-25776 NN denotes NF-κB
T14763 25777-25787 VBG denotes signalling
T14764 25788-25796 NNS denotes proteins
T14765 25797-25806 VBG denotes including
T14766 25807-25811 NNP denotes NEMO
T14767 25811-25812 , denotes ,
T14768 25813-25818 NNP denotes TRAF2
T14769 25818-25819 , denotes ,
T14770 25820-25825 NNP denotes TRAF6
T14771 25825-25826 , denotes ,
T14772 25827-25832 NNP denotes TRAF7
T14773 25832-25833 , denotes ,
T14774 25834-25838 NNP denotes RIP1
T14775 25839-25842 CC denotes and
T14776 25843-25847 NNP denotes TAK1
T14777 25847-25848 . denotes .
T14778 25849-25853 JJ denotes Many
T14779 25854-25856 IN denotes of
T14780 25857-25862 DT denotes these
T14781 25863-25866 VBP denotes are
T14782 25867-25871 RB denotes also
T14783 25872-25880 VBN denotes targeted
T14784 25881-25883 IN denotes by
T14785 25884-25887 NNP denotes A20
T14786 25888-25891 CC denotes and
T14787 25892-25894 PRP denotes it
T14788 25895-25897 VBZ denotes is
T14789 25898-25903 RB denotes still
T14790 25904-25907 RB denotes not
T14791 25908-25913 JJ denotes clear
T14792 25914-25917 WRB denotes why
T14793 25918-25921 DT denotes the
T14794 25922-25926 NN denotes cell
T14795 25927-25932 VBZ denotes needs
T14796 25933-25936 NNP denotes A20
T14797 25937-25939 RB denotes as
T14798 25940-25944 RB denotes well
T14799 25945-25947 IN denotes as
T14800 25948-25952 NNP denotes CYLD
T14801 25953-25955 TO denotes to
T14802 25956-25963 VB denotes control
T14803 25964-25969 JJ denotes NF-κB
T14804 25970-25980 NN denotes activation
T14805 25980-25981 . denotes .
T14806 25982-25984 IN denotes As
T14807 25985-25988 NNP denotes A20
T14808 25989-25991 VBZ denotes is
T14809 25992-25996 RB denotes only
T14810 25997-26006 VBN denotes expressed
T14811 26007-26009 IN denotes in
T14812 26010-26014 JJ denotes many
T14813 26015-26019 NN denotes cell
T14814 26020-26025 NNS denotes types
T14815 26026-26030 IN denotes upon
T14816 26031-26042 NN denotes stimulation
T14817 26042-26043 , denotes ,
T14818 26044-26046 PRP denotes it
T14819 26047-26050 VBZ denotes has
T14820 26051-26055 VBN denotes been
T14821 26056-26065 VBN denotes suggested
T14822 26066-26070 IN denotes that
T14823 26071-26075 DT denotes this
T14824 26076-26083 NN denotes protein
T14825 26084-26090 RB denotes mainly
T14826 26091-26100 VBZ denotes regulates
T14827 26101-26106 RB denotes later
T14828 26107-26113 NNS denotes phases
T14829 26114-26116 IN denotes of
T14830 26117-26122 JJ denotes NF-κB
T14831 26123-26133 NN denotes signalling
T14832 26133-26134 , denotes ,
T14833 26135-26142 IN denotes whereas
T14834 26143-26147 NNP denotes CYLD
T14835 26148-26153 MD denotes would
T14836 26154-26162 VB denotes regulate
T14837 26163-26175 JJ denotes constitutive
T14838 26176-26179 CC denotes and
T14839 26180-26185 JJ denotes early
T14840 26186-26196 NN denotes signalling
T14841 26196-26197 . denotes .
T14842 26198-26200 IN denotes In
T14843 26201-26209 NN denotes addition
T14844 26209-26210 , denotes ,
T14845 26211-26216 PRP$ denotes their
T14846 26217-26225 JJ denotes relative
T14847 26226-26234 NN denotes activity
T14848 26235-26240 MD denotes might
T14849 26241-26245 RB denotes also
T14850 26246-26248 VB denotes be
T14851 26249-26258 JJ denotes cell-type
T14852 26259-26268 JJ denotes dependent
T14853 26269-26270 NNP denotes [
T14854 26270-26272 CD denotes 64
T14855 26272-26273 NNP denotes ]
T14856 26273-26274 . denotes .
T14857 26275-26288 RB denotes Interestingly
T14858 26288-26289 , denotes ,
T14859 26290-26294 NNP denotes CYLD
T14860 26295-26298 VBZ denotes has
T14861 26299-26303 VBN denotes been
T14862 26304-26309 VBN denotes shown
T14863 26310-26312 TO denotes to
T14864 26313-26323 RB denotes negatively
T14865 26324-26332 VB denotes regulate
T14866 26333-26337 NNP denotes RANK
T14867 26338-26348 NN denotes signalling
T14868 26349-26352 CC denotes and
T14869 26353-26371 NN denotes osteoclastogenesis
T14870 26372-26374 IN denotes in
T14871 26375-26379 NNS denotes mice
T14872 26380-26381 NNP denotes [
T14873 26381-26383 CD denotes 65
T14874 26383-26384 NNP denotes ]
T14875 26384-26385 . denotes .
T14876 26386-26390 NN denotes Mice
T14877 26391-26395 IN denotes with
T14878 26396-26397 DT denotes a
T14879 26398-26405 JJ denotes genetic
T14880 26406-26416 NN denotes deficiency
T14881 26417-26419 IN denotes of
T14882 26420-26424 NNP denotes CYLD
T14883 26425-26429 VBP denotes have
T14884 26430-26438 JJ denotes aberrant
T14885 26439-26449 NN denotes osteoclast
T14886 26450-26465 NN denotes differentiation
T14887 26466-26469 CC denotes and
T14888 26470-26477 VB denotes develop
T14889 26478-26484 JJ denotes severe
T14890 26485-26497 NN denotes osteoporosis
T14891 26497-26498 . denotes .
T14892 26499-26509 NNP denotes Osteoclast
T14893 26510-26520 NNS denotes precursors
T14894 26521-26523 IN denotes of
T14895 26524-26529 DT denotes these
T14896 26530-26534 NNS denotes mice
T14897 26535-26538 VBP denotes are
T14898 26539-26555 JJ denotes hyper-responsive
T14899 26556-26558 TO denotes to
T14900 26559-26572 JJ denotes RANKL-induced
T14901 26573-26588 NN denotes differentiation
T14902 26589-26592 CC denotes and
T14903 26593-26600 VB denotes produce
T14904 26601-26605 JJR denotes more
T14905 26606-26609 CC denotes and
T14906 26610-26616 JJR denotes larger
T14907 26617-26628 NNS denotes osteoclasts
T14908 26628-26629 . denotes .
T14909 26630-26634 NNP denotes CYLD
T14910 26635-26645 NN denotes expression
T14911 26646-26648 VBZ denotes is
T14912 26649-26657 RB denotes markedly
T14913 26658-26669 VBN denotes upregulated
T14914 26670-26675 IN denotes under
T14915 26676-26686 NNS denotes conditions
T14916 26687-26689 IN denotes of
T14917 26690-26703 JJ denotes RANKL-induced
T14918 26704-26722 NN denotes osteoclastogenesis
T14919 26723-26726 CC denotes and
T14920 26727-26729 VBZ denotes is
T14921 26730-26739 VBN denotes recruited
T14922 26740-26742 TO denotes to
T14923 26743-26756 VBN denotes ubiquitinated
T14924 26757-26762 CD denotes TRAF6
T14925 26763-26766 IN denotes via
T14926 26767-26770 DT denotes the
T14927 26771-26788 JJ denotes ubiquitin-binding
T14928 26789-26796 NN denotes adaptor
T14929 26797-26804 NN denotes protein
T14930 26805-26808 NN denotes p62
T14931 26809-26810 -LRB- denotes (
T14932 26810-26814 RB denotes also
T14933 26815-26820 VBN denotes known
T14934 26821-26823 IN denotes as
T14935 26824-26836 JJ denotes sequestosome
T14936 26837-26838 CD denotes 1
T14937 26838-26839 -RRB- denotes )
T14938 26840-26841 NNP denotes [
T14939 26841-26843 CD denotes 65
T14940 26843-26844 NNP denotes ]
T14941 26844-26845 , denotes ,
T14942 26846-26854 VBN denotes followed
T14943 26855-26857 IN denotes by
T14944 26858-26861 DT denotes the
T14945 26862-26875 JJ denotes CYLD-mediated
T14946 26876-26892 NN denotes deubiquitination
T14947 26893-26895 IN denotes of
T14948 26896-26901 CD denotes TRAF6
T14949 26901-26902 . denotes .
T14950 26903-26905 IN denotes In
T14951 26906-26910 DT denotes this
T14952 26911-26918 NN denotes context
T14953 26918-26919 , denotes ,
T14954 26920-26922 PRP denotes it
T14955 26923-26925 VBZ denotes is
T14956 26926-26931 JJ denotes worth
T14957 26932-26942 VBG denotes mentioning
T14958 26943-26947 IN denotes that
T14959 26948-26958 JJ denotes transgenic
T14960 26959-26963 NNS denotes mice
T14961 26964-26974 VBG denotes expressing
T14962 26975-26976 DT denotes a
T14963 26977-26984 VBN denotes mutated
T14964 26985-26989 NN denotes form
T14965 26990-26992 IN denotes of
T14966 26993-26996 CD denotes p62
T14967 26997-27001 RB denotes also
T14968 27002-27009 NN denotes display
T14969 27010-27018 JJ denotes abnormal
T14970 27019-27037 NN denotes osteoclastogenesis
T14971 27038-27041 CC denotes and
T14972 27042-27049 VB denotes develop
T14973 27050-27061 JJ denotes progressive
T14974 27062-27066 NN denotes bone
T14975 27067-27071 NN denotes loss
T14976 27072-27073 NNP denotes [
T14977 27073-27075 CD denotes 66
T14978 27075-27076 NNP denotes ]
T14979 27076-27077 . denotes .
T14980 27078-27083 DT denotes These
T14981 27084-27092 NNS denotes findings
T14982 27093-27100 VBP denotes suggest
T14983 27101-27105 IN denotes that
T14984 27106-27119 JJ denotes CYLD-mediated
T14985 27120-27131 NN denotes inhibi-tion
T14986 27132-27134 IN denotes of
T14987 27135-27147 JJ denotes RANK-induced
T14988 27148-27153 NN denotes NF-κB
T14989 27154-27164 VBG denotes signalling
T14990 27165-27170 NNS denotes plays
T14991 27171-27172 DT denotes a
T14992 27173-27176 JJ denotes key
T14993 27177-27181 NN denotes role
T14994 27182-27184 IN denotes in
T14995 27185-27188 DT denotes the
T14996 27189-27197 JJ denotes negative
T14997 27198-27208 NN denotes regulation
T14998 27209-27211 IN denotes of
T14999 27212-27230 NN denotes osteoclastogenesis
T15000 27231-27234 CC denotes and
T15001 27235-27243 VBP denotes indicate
T15002 27244-27248 NNP denotes CYLD
T15003 27249-27251 IN denotes as
T15004 27252-27253 DT denotes a
T15005 27254-27263 JJ denotes potential
T15006 27264-27271 JJ denotes genetic
T15007 27272-27278 NN denotes factor
T15008 27279-27287 VBN denotes involved
T15009 27288-27290 IN denotes in
T15010 27291-27294 DT denotes the
T15011 27295-27304 NN denotes pathology
T15012 27305-27307 IN denotes of
T15013 27308-27312 NN denotes bone
T15014 27313-27322 NNS denotes disorders
T15015 27323-27327 JJ denotes such
T15016 27328-27330 IN denotes as
T15017 27331-27333 NNP denotes RA
T15018 27333-27334 . denotes .
T15830 27336-27357 NN denotes Single-immunoglobulin
T15831 27358-27362 NNP denotes IL-1
T15832 27363-27379 JJ denotes receptor-related
T15833 27380-27387 NN denotes protein
T15834 27388-27409 NN denotes Single-immunoglobulin
T15835 27410-27414 NNP denotes IL-1
T15836 27415-27431 JJ denotes receptor-related
T15837 27432-27433 -LRB- denotes (
T15838 27433-27439 NNP denotes SIGIRR
T15839 27439-27440 -RRB- denotes )
T15840 27441-27448 NN denotes protein
T15841 27448-27449 , denotes ,
T15842 27450-27454 RB denotes also
T15843 27455-27460 VBN denotes known
T15844 27461-27463 IN denotes as
T15845 27464-27469 CD denotes TIR-8
T15846 27469-27470 , denotes ,
T15847 27471-27473 VBZ denotes is
T15848 27474-27475 DT denotes a
T15849 27476-27482 NN denotes member
T15850 27483-27485 IN denotes of
T15851 27486-27489 DT denotes the
T15852 27490-27496 NNP denotes TLR/IL
T15853 27496-27498 CD denotes -1
T15854 27498-27499 NNP denotes R
T15855 27500-27506 NN denotes family
T15856 27507-27511 WDT denotes that
T15857 27512-27515 VBZ denotes has
T15858 27516-27520 VBN denotes been
T15859 27521-27532 RB denotes extensively
T15860 27533-27546 VBN denotes characterised
T15861 27547-27549 IN denotes as
T15862 27550-27552 DT denotes an
T15863 27553-27562 NN denotes inhibitor
T15864 27563-27565 IN denotes of
T15865 27566-27571 NN denotes IL-1R
T15866 27572-27575 CC denotes and
T15867 27576-27579 NNP denotes TLR
T15868 27580-27590 NN denotes signalling
T15869 27590-27591 , denotes ,
T15870 27592-27600 RB denotes probably
T15871 27601-27608 IN denotes through
T15872 27609-27615 JJ denotes direct
T15873 27616-27627 NN denotes interaction
T15874 27628-27632 IN denotes with
T15875 27633-27638 DT denotes these
T15876 27639-27648 NNS denotes receptors
T15877 27648-27649 , denotes ,
T15878 27650-27655 NNP denotes MyD88
T15879 27655-27656 , denotes ,
T15880 27657-27662 NNP denotes IRAK1
T15881 27663-27665 CC denotes or
T15882 27666-27671 NNP denotes TRAF6
T15883 27672-27673 NNP denotes [
T15884 27673-27675 CD denotes 67
T15885 27675-27676 NNP denotes ]
T15886 27677-27678 -LRB- denotes (
T15887 27678-27684 NNP denotes Figure
T15888 27685-27686 CD denotes 1
T15889 27686-27687 -RRB- denotes )
T15890 27687-27688 . denotes .
T15891 27689-27694 VBN denotes Given
T15892 27695-27698 DT denotes the
T15893 27699-27708 JJ denotes important
T15894 27709-27713 NN denotes role
T15895 27714-27716 IN denotes of
T15896 27717-27722 NN denotes IL-1R
T15897 27723-27726 CC denotes and
T15898 27727-27730 NNP denotes TLR
T15899 27731-27741 VBG denotes signalling
T15900 27742-27744 IN denotes in
T15901 27745-27748 DT denotes the
T15902 27749-27756 JJ denotes chronic
T15903 27757-27769 NN denotes inflammation
T15904 27770-27778 VBD denotes observed
T15905 27779-27781 IN denotes in
T15906 27782-27784 NNP denotes RA
T15907 27785-27786 NNP denotes [
T15908 27786-27788 CD denotes 68
T15909 27788-27789 NNP denotes ]
T15910 27789-27790 , denotes ,
T15911 27791-27792 DT denotes a
T15912 27793-27803 JJ denotes regulatory
T15913 27804-27808 NN denotes role
T15914 27809-27812 IN denotes for
T15915 27813-27819 NNP denotes SIGIRR
T15916 27820-27822 IN denotes in
T15917 27823-27825 NNP denotes RA
T15918 27826-27828 VBZ denotes is
T15919 27829-27832 RB denotes not
T15920 27833-27841 JJ denotes unlikely
T15921 27841-27842 . denotes .
T15922 27843-27849 NNP denotes SIGIRR
T15923 27850-27853 VBZ denotes has
T15924 27854-27855 DT denotes a
T15925 27856-27860 RB denotes very
T15926 27861-27871 VBN denotes restricted
T15927 27872-27882 NN denotes expression
T15928 27883-27890 NN denotes pattern
T15929 27890-27891 , denotes ,
T15930 27892-27897 VBG denotes being
T15931 27898-27907 VBN denotes expressed
T15932 27908-27910 IN denotes in
T15933 27911-27921 JJ denotes epithelial
T15934 27922-27927 NNS denotes cells
T15935 27927-27928 , denotes ,
T15936 27929-27938 NNS denotes monocytes
T15937 27939-27942 CC denotes and
T15938 27943-27951 NN denotes immature
T15939 27952-27961 JJ denotes dendritic
T15940 27962-27967 NNS denotes cells
T15941 27967-27968 , denotes ,
T15942 27969-27972 CC denotes but
T15943 27973-27976 RB denotes not
T15944 27977-27979 IN denotes in
T15945 27980-27986 JJ denotes mature
T15946 27987-27999 NNS denotes macro-phages
T15947 28000-28001 NNP denotes [
T15948 28001-28006 CD denotes 69,70
T15949 28006-28007 NNP denotes ]
T15950 28007-28008 . denotes .
T15951 28009-28017 RB denotes Recently
T15952 28017-28018 , denotes ,
T15953 28019-28025 NNP denotes SIGIRR
T15954 28026-28040 NN denotes overexpression
T15955 28041-28044 VBD denotes was
T15956 28045-28050 VBN denotes shown
T15957 28051-28053 TO denotes to
T15958 28054-28061 VB denotes inhibit
T15959 28062-28065 DT denotes the
T15960 28066-28077 JJ denotes spontaneous
T15961 28078-28085 NN denotes release
T15962 28086-28088 IN denotes of
T15963 28089-28101 JJ denotes inflammatory
T15964 28102-28111 NNS denotes cytokines
T15965 28112-28114 IN denotes by
T15966 28115-28120 JJ denotes human
T15967 28121-28123 NNP denotes RA
T15968 28124-28132 JJ denotes synovial
T15969 28133-28138 NNS denotes cells
T15970 28138-28139 . denotes .
T15971 28140-28144 DT denotes This
T15972 28145-28155 JJ denotes inhibitory
T15973 28156-28164 NN denotes function
T15974 28165-28167 IN denotes of
T15975 28168-28174 NNP denotes SIGIRR
T15976 28175-28178 VBD denotes was
T15977 28179-28186 JJ denotes further
T15978 28187-28196 VBN denotes confirmed
T15979 28197-28199 IN denotes in
T15980 28200-28204 NN denotes vivo
T15981 28204-28205 , denotes ,
T15982 28206-28211 IN denotes since
T15983 28212-28228 JJ denotes SIGIRR-deficient
T15984 28229-28233 NNS denotes mice
T15985 28234-28243 VBD denotes developed
T15986 28244-28245 DT denotes a
T15987 28246-28250 RBR denotes more
T15988 28251-28257 JJ denotes severe
T15989 28258-28265 NN denotes disease
T15990 28266-28268 IN denotes in
T15991 28269-28284 JJ denotes zymosan-induced
T15992 28285-28294 NNS denotes arthritis
T15993 28294-28295 , denotes ,
T15994 28296-28298 RB denotes as
T15995 28299-28303 RB denotes well
T15996 28304-28306 IN denotes as
T15997 28307-28323 JJ denotes collagen-induced
T15998 28324-28333 NNS denotes arthritis
T15999 28334-28339 NN denotes mouse
T16000 28340-28346 NNS denotes models
T16001 28347-28348 NNP denotes [
T16002 28348-28350 CD denotes 70
T16003 28350-28351 NNP denotes ]
T16004 28351-28352 . denotes .
T16005 28353-28355 PRP denotes It
T16006 28356-28360 MD denotes will
T16007 28361-28363 VB denotes be
T16008 28364-28375 JJ denotes interesting
T16009 28376-28378 TO denotes to
T16010 28379-28386 VB denotes compare
T16011 28387-28390 DT denotes the
T16012 28391-28401 NN denotes expression
T16013 28402-28404 IN denotes of
T16014 28405-28411 NNP denotes SIGIRR
T16015 28412-28414 IN denotes in
T16016 28415-28417 NNP denotes RA
T16017 28418-28426 NNS denotes patients
T16018 28427-28431 IN denotes with
T16019 28432-28435 PRP$ denotes its
T16020 28436-28446 NN denotes expression
T16021 28447-28449 IN denotes in
T16022 28450-28457 NN denotes control
T16023 28458-28466 NNS denotes patients
T16024 28466-28467 , denotes ,
T16025 28468-28470 CC denotes or
T16026 28471-28473 TO denotes to
T16027 28474-28485 VB denotes investigate
T16028 28486-28493 IN denotes whether
T16029 28494-28497 DT denotes the
T16030 28498-28506 NN denotes function
T16031 28507-28509 IN denotes of
T16032 28510-28516 NNP denotes SIGIRR
T16033 28517-28519 VBZ denotes is
T16034 28520-28531 VBN denotes compromised
T16035 28532-28534 IN denotes in
T16036 28535-28537 NNP denotes RA
T16037 28538-28546 NNS denotes patients
T16038 28546-28547 . denotes .
T16039 28548-28555 IN denotes Because
T16040 28556-28558 IN denotes of
T16041 28559-28562 PRP$ denotes its
T16042 28563-28573 VBN denotes restricted
T16043 28574-28584 NN denotes expression
T16044 28585-28592 NN denotes pattern
T16045 28592-28593 , denotes ,
T16046 28594-28600 NNP denotes SIGIRR
T16047 28601-28604 MD denotes may
T16048 28605-28609 RB denotes also
T16049 28610-28612 VB denotes be
T16050 28613-28615 DT denotes an
T16051 28616-28627 JJ denotes interesting
T16052 28628-28639 JJ denotes therapeutic
T16053 28640-28646 NN denotes target
T16054 28647-28649 IN denotes in
T16055 28650-28652 NNP denotes RA
T16056 28652-28653 . denotes .
T16746 28655-28658 NNP denotes TNF
T16747 28659-28678 JJ denotes receptor-associated
T16748 28679-28685 NN denotes factor
T16749 28686-28687 CD denotes 1
T16750 28688-28693 CD denotes TRAF1
T16751 28694-28696 VBZ denotes is
T16752 28697-28698 DT denotes a
T16753 28699-28705 JJ denotes unique
T16754 28706-28712 NN denotes member
T16755 28713-28715 IN denotes of
T16756 28716-28719 DT denotes the
T16757 28720-28724 NNP denotes TRAF
T16758 28725-28732 NN denotes protein
T16759 28733-28739 NN denotes family
T16760 28740-28747 IN denotes because
T16761 28748-28750 PRP denotes it
T16762 28751-28756 VBZ denotes lacks
T16763 28757-28758 DT denotes a
T16764 28759-28763 NN denotes RING
T16765 28764-28770 NN denotes finger
T16766 28771-28777 NN denotes domain
T16767 28778-28781 CC denotes and
T16768 28782-28791 RB denotes therefore
T16769 28792-28797 VBZ denotes lacks
T16770 28798-28807 NN denotes ubiquitin
T16771 28808-28814 NN denotes ligase
T16772 28815-28823 NN denotes activity
T16773 28823-28824 . denotes .
T16774 28825-28837 VBG denotes Accumulating
T16775 28838-28842 NNS denotes data
T16776 28843-28850 VBP denotes support
T16777 28851-28852 DT denotes a
T16778 28853-28857 NN denotes role
T16779 28858-28861 IN denotes for
T16780 28862-28867 CD denotes TRAF1
T16781 28868-28870 IN denotes as
T16782 28871-28875 DT denotes both
T16783 28876-28877 DT denotes a
T16784 28878-28886 JJ denotes negative
T16785 28887-28890 CC denotes and
T16786 28891-28892 DT denotes a
T16787 28893-28901 JJ denotes positive
T16788 28902-28911 NN denotes modulator
T16789 28912-28914 IN denotes of
T16790 28915-28920 JJ denotes NF-κB
T16791 28921-28931 NN denotes signalling
T16792 28932-28934 IN denotes by
T16793 28935-28942 JJ denotes certain
T16794 28943-28946 NNP denotes TNF
T16795 28947-28953 NN denotes family
T16796 28954-28963 NNS denotes receptors
T16797 28963-28964 , denotes ,
T16798 28965-28973 RB denotes possibly
T16799 28974-28976 IN denotes in
T16800 28977-28978 DT denotes a
T16801 28979-28998 JJ denotes cell-type-dependent
T16802 28999-29005 NN denotes manner
T16803 29006-29007 NNP denotes [
T16804 29007-29012 CD denotes 71,72
T16805 29012-29013 NNP denotes ]
T16806 29013-29014 . denotes .
T16807 29015-29025 NN denotes Expression
T16808 29026-29028 IN denotes of
T16809 29029-29034 CD denotes TRAF1
T16810 29035-29037 VBZ denotes is
T16811 29038-29047 JJ denotes inducible
T16812 29048-29050 IN denotes by
T16813 29051-29054 NNP denotes TNF
T16814 29055-29058 CC denotes and
T16815 29059-29073 NN denotes overexpression
T16816 29074-29076 IN denotes of
T16817 29077-29082 CD denotes TRAF1
T16818 29083-29091 NNS denotes inhibits
T16819 29092-29103 JJ denotes TNF-induced
T16820 29104-29109 NN denotes NF-κB
T16821 29110-29120 NN denotes activation
T16822 29120-29121 . denotes .
T16823 29122-29137 JJ denotes TRAF1-deficient
T16824 29138-29139 NNP denotes T
T16825 29140-29145 NNS denotes cells
T16826 29146-29149 VBP denotes are
T16827 29150-29166 JJ denotes hyper-responsive
T16828 29167-29169 TO denotes to
T16829 29170-29173 NNP denotes TNF
T16830 29173-29174 , denotes ,
T16831 29175-29179 IN denotes with
T16832 29180-29188 JJ denotes enhanced
T16833 29189-29202 NN denotes proliferation
T16834 29203-29206 CC denotes and
T16835 29207-29217 NN denotes activation
T16836 29218-29220 IN denotes of
T16837 29221-29224 DT denotes the
T16838 29225-29230 NN denotes NF-κB
T16839 29231-29241 VBG denotes signalling
T16840 29242-29249 NN denotes pathway
T16841 29249-29250 . denotes .
T16842 29251-29256 CD denotes TRAF1
T16843 29257-29261 RB denotes also
T16844 29262-29271 NNS denotes functions
T16845 29272-29274 IN denotes as
T16846 29275-29276 DT denotes a
T16847 29277-29285 JJ denotes negative
T16848 29286-29295 NN denotes regulator
T16849 29296-29298 IN denotes of
T16850 29299-29311 JJ denotes CD40-induced
T16851 29312-29317 NN denotes NF-κB
T16852 29318-29328 NN denotes activation
T16853 29328-29329 . denotes .
T16854 29330-29345 JJ denotes TRAF1-deficient
T16855 29346-29355 JJ denotes dendritic
T16856 29356-29361 NNS denotes cells
T16857 29361-29362 , denotes ,
T16858 29363-29370 RB denotes however
T16859 29370-29371 , denotes ,
T16860 29372-29376 VBP denotes show
T16861 29377-29387 JJ denotes attenuated
T16862 29388-29397 NNS denotes responses
T16863 29398-29400 TO denotes to
T16864 29401-29410 JJ denotes secondary
T16865 29411-29422 NN denotes stimulation
T16866 29423-29425 IN denotes by
T16867 29426-29441 JJ denotes TRAF2-dependent
T16868 29442-29449 NNS denotes factors
T16869 29449-29450 , denotes ,
T16870 29451-29461 VBG denotes suggesting
T16871 29462-29463 DT denotes a
T16872 29464-29472 JJ denotes positive
T16873 29473-29483 JJ denotes regulatory
T16874 29484-29488 NN denotes role
T16875 29489-29491 IN denotes in
T16876 29492-29497 DT denotes these
T16877 29498-29503 NNS denotes cells
T16878 29503-29504 . denotes .
T16879 29505-29508 DT denotes The
T16880 29509-29518 NN denotes mechanism
T16881 29519-29521 IN denotes by
T16882 29522-29527 WDT denotes which
T16883 29528-29533 NNP denotes TRAF1
T16884 29534-29543 VBZ denotes modulates
T16885 29544-29546 SYM denotes NF
T16886 29546-29547 : denotes -
T16887 29548-29550 NN denotes κB
T16888 29551-29561 NN denotes activation
T16889 29562-29564 VBZ denotes is
T16890 29565-29570 RB denotes still
T16891 29571-29578 JJ denotes unclear
T16892 29578-29579 . denotes .
T16893 29580-29584 JJS denotes Most
T16894 29585-29593 RB denotes probably
T16895 29593-29594 , denotes ,
T16896 29595-29600 CD denotes TRAF1
T16897 29601-29609 VBZ denotes competes
T16898 29610-29614 IN denotes with
T16899 29615-29619 NNP denotes TRAF
T16900 29620-29626 NN denotes family
T16901 29627-29634 NNS denotes members
T16902 29635-29638 IN denotes for
T16903 29639-29646 JJ denotes binding
T16904 29647-29649 TO denotes to
T16905 29650-29653 DT denotes the
T16906 29654-29662 NN denotes receptor
T16907 29663-29665 CC denotes or
T16908 29666-29671 JJ denotes other
T16909 29672-29682 JJ denotes signalling
T16910 29683-29691 NNS denotes proteins
T16911 29691-29692 . denotes .
T16912 29693-29706 RB denotes Alternatively
T16913 29706-29707 , denotes ,
T16914 29708-29713 NNP denotes TRAF1
T16915 29714-29719 MD denotes might
T16916 29720-29727 VB denotes recruit
T16917 29728-29731 NNP denotes A20
T16918 29732-29736 IN denotes with
T16919 29737-29742 WDT denotes which
T16920 29743-29745 PRP denotes it
T16921 29746-29749 MD denotes can
T16922 29750-29760 RB denotes physically
T16923 29761-29769 VB denotes interact
T16924 29770-29771 NNP denotes [
T16925 29771-29773 CD denotes 73
T16926 29773-29774 NNP denotes ]
T16927 29774-29775 . denotes .
T16928 29776-29777 DT denotes A
T16929 29778-29789 JJ denotes genome-wide
T16930 29790-29801 NN denotes association
T16931 29802-29807 NN denotes study
T16932 29808-29817 VBG denotes examining
T16933 29818-29822 JJR denotes more
T16934 29823-29827 IN denotes than
T16935 29828-29835 CD denotes 300,000
T16936 29836-29840 NNS denotes SNPs
T16937 29841-29846 IN denotes among
T16938 29847-29860 RB denotes approximately
T16939 29861-29866 CD denotes 1,500
T16940 29867-29888 JJ denotes autoantibody-positive
T16941 29889-29891 NNP denotes RA
T16942 29892-29897 NNS denotes cases
T16943 29898-29901 CC denotes and
T16944 29902-29907 CD denotes 1,800
T16945 29908-29916 NNS denotes controls
T16946 29917-29927 VBD denotes identified
T16947 29928-29929 DT denotes a
T16948 29930-29937 JJ denotes genetic
T16949 29938-29947 NN denotes variation
T16950 29948-29950 IN denotes at
T16951 29951-29954 DT denotes the
T16952 29955-29971 NN denotes TRAF1-complement
T16953 29972-29981 NN denotes component
T16954 29982-29983 CD denotes 5
T16955 29984-29989 NN denotes locus
T16956 29990-29992 IN denotes as
T16957 29993-29995 DT denotes an
T16958 29996-30005 JJ denotes important
T16959 30006-30008 NNP denotes RA
T16960 30009-30013 NN denotes risk
T16961 30014-30019 VBZ denotes locus
T16962 30020-30021 NNP denotes [
T16963 30021-30023 CD denotes 74
T16964 30023-30024 NNP denotes ]
T16965 30024-30025 . denotes .
T16966 30026-30036 JJ denotes Subsequent
T16967 30037-30041 NN denotes work
T16968 30042-30051 VBZ denotes indicates
T16969 30052-30056 IN denotes that
T16970 30057-30062 CD denotes TRAF1
T16971 30063-30065 VBZ denotes is
T16972 30066-30070 RBR denotes more
T16973 30071-30077 JJ denotes likely
T16974 30078-30080 TO denotes to
T16975 30081-30083 VB denotes be
T16976 30084-30087 DT denotes the
T16977 30088-30097 JJ denotes causative
T16978 30098-30103 NN denotes locus
T16979 30104-30105 NNP denotes [
T16980 30105-30107 CD denotes 75
T16981 30107-30108 NNP denotes ]
T16982 30108-30109 . denotes .
T16983 30110-30116 JJ denotes Recent
T16984 30117-30121 NN denotes work
T16985 30122-30124 IN denotes in
T16986 30125-30126 DT denotes a
T16987 30127-30133 JJ denotes Korean
T16988 30134-30144 NN denotes population
T16989 30145-30149 RB denotes also
T16990 30150-30162 VBZ denotes demonstrates
T16991 30163-30170 JJ denotes genetic
T16992 30171-30182 NN denotes association
T16993 30183-30185 IN denotes of
T16994 30186-30189 DT denotes the
T16995 30190-30195 CD denotes TRAF1
T16996 30196-30202 NN denotes region
T16997 30203-30207 IN denotes with
T16998 30208-30210 NNP denotes RA
T16999 30211-30212 NNP denotes [
T17000 30212-30214 CD denotes 76
T17001 30214-30215 NNP denotes ]
T17002 30215-30216 . denotes .
T18039 30218-30227 NNS denotes microRNAs
T18040 30228-30234 NNS denotes miRNAs
T18041 30235-30238 VBP denotes are
T18042 30239-30247 RB denotes recently
T18043 30248-30258 VBN denotes discovered
T18044 30259-30269 NNS denotes regulators
T18045 30270-30272 IN denotes of
T18046 30273-30277 NN denotes gene
T18047 30278-30288 NN denotes expression
T18048 30289-30292 CC denotes and
T18049 30293-30302 VB denotes represent
T18050 30303-30304 DT denotes a
T18051 30305-30310 NN denotes class
T18052 30311-30313 IN denotes of
T18053 30314-30323 VBG denotes noncoding
T18054 30324-30327 NNP denotes RNA
T18055 30328-30337 NNS denotes molecules
T18056 30338-30347 JJ denotes essential
T18057 30348-30350 IN denotes in
T18058 30351-30355 JJ denotes many
T18059 30356-30364 JJ denotes cellular
T18060 30365-30368 CC denotes and
T18061 30369-30382 JJ denotes developmental
T18062 30383-30392 NNS denotes processes
T18063 30392-30393 , denotes ,
T18064 30394-30403 VBG denotes including
T18065 30404-30410 JJ denotes immune
T18066 30411-30420 NNS denotes responses
T18067 30421-30424 CC denotes and
T18068 30425-30437 NN denotes inflammation
T18069 30437-30438 . denotes .
T18070 30439-30443 PRP denotes They
T18071 30444-30448 NN denotes bind
T18072 30449-30452 DT denotes the
T18073 30453-30454 CD denotes 3
T18074 30454-30455 '' denotes '
T18075 30455-30456 : denotes -
T18076 30456-30459 NNP denotes UTR
T18077 30460-30462 IN denotes of
T18078 30463-30469 NN denotes target
T18079 30470-30475 NNS denotes mRNAs
T18080 30476-30483 VBG denotes leading
T18081 30484-30486 TO denotes to
T18082 30487-30490 DT denotes the
T18083 30491-30501 NN denotes repression
T18084 30502-30504 IN denotes of
T18085 30505-30512 NN denotes protein
T18086 30513-30523 NN denotes expression
T18087 30524-30527 CC denotes and
T18088 30528-30531 DT denotes the
T18089 30532-30541 NN denotes promotion
T18090 30542-30544 IN denotes of
T18091 30545-30551 NN denotes target
T18092 30552-30556 NNP denotes mRNA
T18093 30557-30568 NN denotes degradation
T18094 30569-30570 NNP denotes [
T18095 30570-30572 CD denotes 77
T18096 30572-30573 NNP denotes ]
T18097 30573-30574 . denotes .
T18098 30575-30583 JJ denotes miR-146a
T18099 30583-30584 NN denotes /
T18100 30584-30585 NN denotes b
T18101 30586-30589 CC denotes and
T18102 30590-30597 NN denotes miR-155
T18103 30598-30601 VBP denotes are
T18104 30602-30604 IN denotes of
T18105 30605-30615 JJ denotes particular
T18106 30616-30624 NN denotes interest
T18107 30625-30628 IN denotes for
T18108 30629-30641 JJ denotes inflammatory
T18109 30642-30652 NN denotes signalling
T18110 30653-30655 TO denotes to
T18111 30656-30661 NNP denotes NF-κB
T18112 30661-30662 , denotes ,
T18113 30663-30668 IN denotes since
T18114 30669-30674 DT denotes these
T18115 30675-30681 NNS denotes miRNAs
T18116 30682-30685 MD denotes can
T18117 30686-30688 VB denotes be
T18118 30689-30696 VBN denotes induced
T18119 30697-30699 IN denotes by
T18120 30700-30712 JJ denotes inflammatory
T18121 30713-30720 NNS denotes stimuli
T18122 30721-30725 JJ denotes such
T18123 30726-30728 IN denotes as
T18124 30729-30734 NN denotes IL-1β
T18125 30734-30735 , denotes ,
T18126 30736-30739 NNP denotes TNF
T18127 30740-30743 CC denotes and
T18128 30744-30748 NNP denotes TLRs
T18129 30749-30750 NNP denotes [
T18130 30750-30755 CD denotes 78,79
T18131 30755-30756 NNP denotes ]
T18132 30756-30757 . denotes .
T18133 30758-30760 IN denotes In
T18134 30761-30769 NN denotes addition
T18135 30769-30770 , denotes ,
T18136 30771-30779 NN denotes miR-146a
T18137 30780-30782 VBZ denotes is
T18138 30783-30785 DT denotes an
T18139 30786-30801 JJ denotes NF-κB-dependent
T18140 30802-30806 NN denotes gene
T18141 30806-30807 , denotes ,
T18142 30808-30811 CC denotes and
T18143 30812-30815 DT denotes the
T18144 30816-30821 NN denotes NF-κB
T18145 30822-30832 VBG denotes signalling
T18146 30833-30842 NNS denotes molecules
T18147 30843-30848 NNP denotes IRAK1
T18148 30849-30852 CC denotes and
T18149 30853-30858 NNP denotes TRAF6
T18150 30859-30863 VBD denotes were
T18151 30864-30874 VBN denotes identified
T18152 30875-30877 IN denotes as
T18153 30878-30884 NN denotes target
T18154 30885-30890 NNS denotes genes
T18155 30891-30893 IN denotes of
T18156 30894-30902 JJ denotes miR-146a
T18157 30903-30904 NNP denotes [
T18158 30904-30906 CD denotes 78
T18159 30906-30907 NNP denotes ]
T18160 30908-30909 -LRB- denotes (
T18161 30909-30915 NNP denotes Figure
T18162 30916-30917 CD denotes 1
T18163 30917-30918 -RRB- denotes )
T18164 30918-30919 . denotes .
T18165 30920-30929 RB denotes Similarly
T18166 30929-30930 , denotes ,
T18167 30931-30938 NN denotes miR-155
T18168 30939-30942 VBD denotes was
T18169 30943-30948 VBN denotes shown
T18170 30949-30951 TO denotes to
T18171 30952-30958 VB denotes target
T18172 30959-30970 NNS denotes transcripts
T18173 30971-30974 IN denotes for
T18174 30975-30978 DT denotes the
T18175 30979-30984 NN denotes NF-κB
T18176 30985-30995 VBG denotes signalling
T18177 30996-31005 NNS denotes molecules
T18178 31006-31010 NNP denotes IKKε
T18179 31011-31014 CC denotes and
T18180 31015-31019 NNP denotes RIP1
T18181 31020-31021 NNP denotes [
T18182 31021-31026 CD denotes 79,80
T18183 31026-31027 NNP denotes ]
T18184 31027-31028 . denotes .
T18185 31029-31036 RB denotes Notably
T18186 31036-31037 , denotes ,
T18187 31038-31042 DT denotes both
T18188 31043-31050 NNP denotes miR-146
T18189 31051-31054 CC denotes and
T18190 31055-31062 NNP denotes miR-155
T18191 31063-31066 VBP denotes are
T18192 31067-31076 VBN denotes expressed
T18193 31077-31079 IN denotes at
T18194 31080-31086 JJR denotes higher
T18195 31087-31093 NNS denotes levels
T18196 31094-31096 IN denotes in
T18197 31097-31099 NNP denotes RA
T18198 31100-31108 JJ denotes synovial
T18199 31109-31120 NNS denotes fibroblasts
T18200 31121-31124 CC denotes and
T18201 31125-31133 JJ denotes synovial
T18202 31134-31140 NN denotes tissue
T18203 31141-31142 NNP denotes [
T18204 31142-31147 CD denotes 81,82
T18205 31147-31148 NNP denotes ]
T18206 31148-31149 , denotes ,
T18207 31150-31152 RB denotes as
T18208 31153-31157 RB denotes well
T18209 31158-31160 IN denotes as
T18210 31161-31163 IN denotes in
T18211 31164-31174 JJ denotes peripheral
T18212 31175-31180 NN denotes blood
T18213 31181-31192 NN denotes mononuclear
T18214 31193-31198 NNS denotes cells
T18215 31199-31201 IN denotes of
T18216 31202-31204 NNP denotes RA
T18217 31205-31213 NNS denotes patients
T18218 31214-31215 NNP denotes [
T18219 31215-31217 CD denotes 83
T18220 31217-31218 NNP denotes ]
T18221 31218-31219 . denotes .
T18222 31220-31228 NN denotes miR-146a
T18223 31229-31231 VBZ denotes is
T18224 31232-31236 RB denotes also
T18225 31237-31250 VBN denotes overexpressed
T18226 31251-31253 IN denotes in
T18227 31254-31257 NNP denotes CD4
T18228 31257-31258 NNP denotes +
T18229 31259-31262 CC denotes and
T18230 31263-31278 JJ denotes IL-17-producing
T18231 31279-31280 NN denotes T
T18232 31281-31286 NNS denotes cells
T18233 31287-31291 IN denotes from
T18234 31292-31294 NNP denotes RA
T18235 31295-31303 NNS denotes patients
T18236 31304-31305 NNP denotes [
T18237 31305-31310 CD denotes 84,85
T18238 31310-31311 NNP denotes ]
T18239 31311-31312 . denotes .
T18240 31313-31326 RB denotes Interestingly
T18241 31326-31327 , denotes ,
T18242 31328-31329 DT denotes a
T18243 31330-31342 NN denotes polymorphism
T18244 31343-31345 IN denotes in
T18245 31346-31349 DT denotes the
T18246 31350-31351 CD denotes 3
T18247 31351-31352 '' denotes '
T18248 31352-31353 : denotes -
T18249 31353-31356 NNP denotes UTR
T18250 31357-31359 IN denotes of
T18251 31360-31363 DT denotes the
T18252 31364-31372 NN denotes miR-146a
T18253 31373-31379 NN denotes target
T18254 31380-31384 NN denotes gene
T18255 31385-31388 VBD denotes was
T18256 31389-31397 RB denotes recently
T18257 31398-31403 VBN denotes shown
T18258 31404-31406 TO denotes to
T18259 31407-31409 VB denotes be
T18260 31410-31420 VBN denotes associated
T18261 31421-31425 IN denotes with
T18262 31426-31428 NNP denotes RA
T18263 31429-31443 NN denotes susceptibility
T18264 31444-31445 NNP denotes [
T18265 31445-31447 CD denotes 86
T18266 31447-31448 NNP denotes ]
T18267 31448-31449 . denotes .
T18268 31450-31457 NN denotes miR-155
T18269 31458-31472 NN denotes overexpression
T18270 31473-31475 IN denotes in
T18271 31476-31484 JJ denotes synovial
T18272 31485-31496 NNS denotes fibroblasts
T18273 31497-31500 VBD denotes was
T18274 31501-31505 JJ denotes able
T18275 31506-31508 TO denotes to
T18276 31509-31516 VB denotes prevent
T18277 31517-31520 DT denotes the
T18278 31521-31524 NNP denotes TLR
T18279 31525-31528 CC denotes and
T18280 31529-31547 JJ denotes cytokine-inducible
T18281 31548-31558 NN denotes expression
T18282 31559-31561 IN denotes of
T18283 31562-31570 JJ denotes specific
T18284 31571-31577 NN denotes matrix
T18285 31578-31596 NNS denotes metalloproteinases
T18286 31597-31601 WDT denotes that
T18287 31602-31609 VBP denotes mediate
T18288 31610-31616 NN denotes tissue
T18289 31617-31628 NN denotes destruction
T18290 31629-31631 IN denotes in
T18291 31632-31634 NNP denotes RA
T18292 31635-31636 NNP denotes [
T18293 31636-31638 CD denotes 81
T18294 31638-31639 NNP denotes ]
T18295 31639-31640 . denotes .
T18296 31641-31649 RB denotes Moreover
T18297 31649-31650 , denotes ,
T18298 31651-31658 NN denotes miR-155
T18299 31659-31662 VBD denotes was
T18300 31663-31668 VBN denotes shown
T18301 31669-31671 TO denotes to
T18302 31672-31679 VB denotes promote
T18303 31680-31683 NNP denotes TNF
T18304 31684-31694 NN denotes production
T18305 31694-31695 , denotes ,
T18306 31696-31697 DT denotes a
T18307 31698-31701 JJ denotes key
T18308 31702-31709 NN denotes process
T18309 31710-31712 IN denotes in
T18310 31713-31716 DT denotes the
T18311 31717-31729 NN denotes pathogenesis
T18312 31730-31732 IN denotes of
T18313 31733-31735 NNP denotes RA
T18314 31736-31737 NNP denotes [
T18315 31737-31739 CD denotes 87
T18316 31739-31740 NNP denotes ]
T18317 31740-31741 . denotes .
T18318 31742-31749 NN denotes miR-146
T18319 31750-31753 CC denotes and
T18320 31754-31761 NN denotes miR-155
T18321 31762-31765 MD denotes may
T18322 31766-31775 RB denotes therefore
T18323 31776-31778 VB denotes be
T18324 31779-31788 JJ denotes important
T18325 31789-31797 JJ denotes negative
T18326 31798-31808 NNS denotes regulators
T18327 31809-31811 IN denotes of
T18328 31812-31824 NN denotes inflammation
T18329 31825-31827 IN denotes in
T18330 31828-31830 NNP denotes RA
T18331 31831-31834 CC denotes and
T18332 31835-31840 PRP$ denotes their
T18333 31841-31850 NN denotes potential
T18334 31851-31854 IN denotes for
T18335 31855-31858 DT denotes the
T18336 31859-31870 NN denotes development
T18337 31871-31873 IN denotes of
T18338 31874-31877 JJ denotes new
T18339 31878-31888 NNS denotes treatments
T18340 31889-31891 VBZ denotes is
T18341 31892-31903 JJ denotes substantial
T18342 31903-31904 . denotes .
T18343 31905-31907 IN denotes In
T18344 31908-31916 NN denotes addition
T18345 31916-31917 , denotes ,
T18346 31918-31923 PRP$ denotes their
T18347 31924-31933 VBN denotes increased
T18348 31934-31944 NN denotes expression
T18349 31945-31947 IN denotes in
T18350 31948-31950 NNP denotes RA
T18351 31951-31959 NNS denotes patients
T18352 31960-31962 VBZ denotes is
T18353 31963-31974 RB denotes potentially
T18354 31975-31981 JJ denotes useful
T18355 31982-31984 IN denotes as
T18356 31985-31986 DT denotes a
T18357 31987-31993 NN denotes marker
T18358 31994-31997 IN denotes for
T18359 31998-32005 NN denotes disease
T18360 32006-32015 NN denotes diagnosis
T18361 32015-32016 , denotes ,
T18362 32017-32028 NN denotes progression
T18363 32028-32029 , denotes ,
T18364 32030-32032 CC denotes or
T18365 32033-32042 NN denotes treatment
T18366 32043-32051 NN denotes efficacy
T18367 32052-32053 NNP denotes [
T18368 32053-32055 CD denotes 88
T18369 32055-32056 NNP denotes ]
T18370 32056-32057 , denotes ,
T18371 32058-32061 CC denotes but
T18372 32062-32066 DT denotes this
T18373 32067-32071 MD denotes will
T18374 32072-32079 VB denotes require
T18375 32080-32092 NN denotes confirmation
T18376 32093-32098 VBG denotes using
T18377 32099-32100 DT denotes a
T18378 32101-32106 JJ denotes large
T18379 32107-32110 CC denotes and
T18380 32111-32123 JJ denotes well-defined
T18381 32124-32130 NN denotes cohort
T18382 32130-32131 . denotes .
T18383 32132-32139 IN denotes Besides
T18384 32140-32147 NNP denotes miR-146
T18385 32148-32151 CC denotes and
T18386 32152-32159 NNP denotes miR-155
T18387 32159-32160 , denotes ,
T18388 32161-32162 DT denotes a
T18389 32163-32169 NN denotes number
T18390 32170-32172 IN denotes of
T18391 32173-32178 JJ denotes other
T18392 32179-32185 NNS denotes miRNAs
T18393 32186-32190 IN denotes with
T18394 32191-32192 DT denotes a
T18395 32193-32202 JJ denotes potential
T18396 32203-32207 NN denotes role
T18397 32208-32210 IN denotes in
T18398 32211-32214 DT denotes the
T18399 32215-32222 NN denotes control
T18400 32223-32225 IN denotes of
T18401 32226-32241 JJ denotes NF-κB-dependent
T18402 32242-32254 JJ denotes inflammatory
T18403 32255-32264 NNS denotes responses
T18404 32265-32267 IN denotes in
T18405 32268-32270 NNP denotes RA
T18406 32271-32280 NN denotes pathology
T18407 32281-32285 VBD denotes were
T18408 32286-32294 RB denotes recently
T18409 32295-32305 VBN denotes identified
T18410 32305-32306 . denotes .
T18411 32307-32309 IN denotes In
T18412 32310-32314 DT denotes this
T18413 32315-32322 NN denotes context
T18414 32322-32323 , denotes ,
T18415 32324-32332 NN denotes miR-124a
T18416 32333-32334 : denotes -
T18417 32335-32336 DT denotes a
T18418 32337-32340 JJ denotes key
T18419 32341-32350 NN denotes regulator
T18420 32351-32353 IN denotes of
T18421 32354-32357 DT denotes the
T18422 32358-32367 NN denotes chemokine
T18423 32368-32376 NN denotes monocyte
T18424 32377-32392 JJ denotes chemoattractant
T18425 32393-32400 NN denotes protein
T18426 32401-32402 LS denotes 1
T18427 32403-32404 : denotes -
T18428 32405-32408 VBD denotes was
T18429 32409-32414 VBN denotes shown
T18430 32415-32417 TO denotes to
T18431 32418-32420 VB denotes be
T18432 32421-32430 VBN denotes decreased
T18433 32431-32433 IN denotes in
T18434 32434-32446 NNS denotes synoviocytes
T18435 32447-32451 IN denotes from
T18436 32452-32454 NNP denotes RA
T18437 32455-32463 NNS denotes patients
T18438 32464-32465 NNP denotes [
T18439 32465-32467 CD denotes 89
T18440 32467-32468 NNP denotes ]
T18441 32468-32469 . denotes .
T18442 32470-32479 RB denotes Similarly
T18443 32479-32480 , denotes ,
T18444 32481-32489 JJ denotes elevated
T18445 32490-32496 NNS denotes levels
T18446 32497-32499 IN denotes of
T18447 32500-32507 NN denotes miR-203
T18448 32508-32509 : denotes -
T18449 32510-32517 VBG denotes leading
T18450 32518-32520 TO denotes to
T18451 32521-32530 VBN denotes increased
T18452 32531-32540 NN denotes secretion
T18453 32541-32543 IN denotes of
T18454 32544-32550 NN denotes matrix
T18455 32551-32570 NN denotes metalloproteinase-1
T18456 32571-32574 CC denotes and
T18457 32575-32579 NN denotes IL-6
T18458 32580-32581 : denotes -
T18459 32582-32586 VBD denotes were
T18460 32587-32595 VBN denotes detected
T18461 32596-32598 IN denotes in
T18462 32599-32601 NNP denotes RA
T18463 32602-32610 JJ denotes synovial
T18464 32611-32622 NNS denotes fibroblasts
T18465 32623-32624 NNP denotes [
T18466 32624-32626 CD denotes 90
T18467 32626-32627 NNP denotes ]
T18468 32627-32628 . denotes .
T18469 32629-32636 RB denotes Finally
T18470 32636-32637 , denotes ,
T18471 32638-32644 NNP denotes miR-16
T18472 32644-32645 , denotes ,
T18473 32646-32653 NNP denotes miR-132
T18474 32653-32654 , denotes ,
T18475 32655-32658 CC denotes and
T18476 32659-32666 JJ denotes miR-223
T18477 32667-32671 VBD denotes were
T18478 32672-32676 RB denotes also
T18479 32677-32682 VBN denotes shown
T18480 32683-32685 TO denotes to
T18481 32686-32690 VB denotes have
T18482 32691-32693 DT denotes an
T18483 32694-32701 JJ denotes altered
T18484 32702-32712 NN denotes expression
T18485 32713-32715 IN denotes in
T18486 32716-32718 NNP denotes RA
T18487 32719-32727 NNS denotes patients
T18488 32727-32728 , denotes ,
T18489 32729-32739 VBG denotes indicating
T18490 32740-32745 PRP$ denotes their
T18491 32746-32755 JJ denotes potential
T18492 32756-32758 IN denotes as
T18493 32759-32769 JJ denotes diagnostic
T18494 32770-32780 NNS denotes biomarkers
T18495 32781-32784 IN denotes for
T18496 32785-32797 NN denotes pathogenesis
T18497 32798-32799 NNP denotes [
T18498 32799-32807 CD denotes 83,88,91
T18499 32807-32808 NNP denotes ]
T18500 32808-32809 . denotes .
T19050 32823-32826 DT denotes The
T19051 32827-32832 NNP denotes NF-κB
T19052 32833-32839 NN denotes family
T19053 32840-32842 IN denotes of
T19054 32843-32856 NN denotes transcription
T19055 32857-32864 NNS denotes factors
T19056 32865-32870 VBZ denotes plays
T19057 32871-32878 JJ denotes crucial
T19058 32879-32884 NNS denotes roles
T19059 32885-32887 IN denotes in
T19060 32888-32891 DT denotes the
T19061 32892-32904 JJ denotes inflammatory
T19062 32905-32914 NNS denotes processes
T19063 32915-32917 IN denotes in
T19064 32918-32920 NNP denotes RA
T19065 32921-32928 VBG denotes leading
T19066 32929-32931 TO denotes to
T19067 32932-32941 NN denotes cartilage
T19068 32942-32945 CC denotes and
T19069 32946-32950 NN denotes bone
T19070 32951-32962 NN denotes destruction
T19071 32962-32963 . denotes .
T19072 32964-32971 VBG denotes Keeping
T19073 32972-32977 JJ denotes NF-κB
T19074 32978-32988 NN denotes activation
T19075 32989-32994 IN denotes under
T19076 32995-33002 NN denotes control
T19077 33003-33006 MD denotes can
T19078 33007-33011 RB denotes thus
T19079 33012-33014 VB denotes be
T19080 33015-33019 RB denotes very
T19081 33020-33029 JJ denotes important
T19082 33030-33033 IN denotes for
T19083 33034-33037 DT denotes the
T19084 33038-33044 NN denotes design
T19085 33045-33047 IN denotes of
T19086 33048-33056 JJ denotes specific
T19087 33057-33069 NNS denotes therapeutics
T19088 33069-33070 . denotes .
T19089 33071-33074 DT denotes The
T19090 33075-33084 NN denotes existence
T19091 33085-33087 IN denotes of
T19092 33088-33096 JJ denotes multiple
T19093 33097-33105 JJ denotes negative
T19094 33106-33116 NNS denotes regulators
T19095 33117-33125 VBG denotes ensuring
T19096 33126-33127 DT denotes a
T19097 33128-33133 JJ denotes tight
T19098 33134-33144 NN denotes regulation
T19099 33145-33147 IN denotes of
T19100 33148-33151 DT denotes the
T19101 33152-33157 NNP denotes NF-κB
T19102 33158-33165 NN denotes pathway
T19103 33165-33166 , denotes ,
T19104 33167-33174 RB denotes however
T19105 33174-33175 , denotes ,
T19106 33176-33182 VBZ denotes raises
T19107 33183-33186 DT denotes the
T19108 33187-33195 NN denotes question
T19109 33196-33198 IN denotes of
T19110 33199-33202 DT denotes the
T19111 33203-33211 JJ denotes specific
T19112 33212-33216 NN denotes role
T19113 33217-33219 IN denotes of
T19114 33220-33224 DT denotes each
T19115 33225-33227 IN denotes of
T19116 33228-33233 DT denotes these
T19117 33234-33244 NNS denotes regulators
T19118 33245-33248 CC denotes and
T19119 33249-33252 DT denotes the
T19120 33253-33265 NN denotes relationship
T19121 33266-33273 IN denotes between
T19122 33274-33278 PRP denotes them
T19123 33278-33279 . denotes .
T19124 33280-33282 IN denotes In
T19125 33283-33291 NN denotes addition
T19126 33291-33292 , denotes ,
T19127 33293-33298 VBN denotes given
T19128 33299-33302 DT denotes the
T19129 33303-33309 NN denotes number
T19130 33310-33312 IN denotes of
T19131 33313-33319 NNS denotes miRNAs
T19132 33320-33322 IN denotes in
T19133 33323-33329 NNS denotes humans
T19134 33330-33333 CC denotes and
T19135 33334-33337 DT denotes the
T19136 33338-33346 JJ denotes multiple
T19137 33347-33352 NNS denotes mRNAs
T19138 33353-33357 PRP denotes they
T19139 33358-33364 VBP denotes target
T19140 33364-33365 , denotes ,
T19141 33366-33373 JJ denotes intense
T19142 33374-33384 NN denotes complexity
T19143 33385-33388 MD denotes can
T19144 33389-33391 VB denotes be
T19145 33392-33400 VBN denotes expected
T19146 33400-33401 . denotes .
T19147 33402-33405 WRB denotes How
T19148 33406-33409 PDT denotes all
T19149 33410-33415 DT denotes these
T19150 33416-33426 JJ denotes regulatory
T19151 33427-33434 NNS denotes signals
T19152 33435-33438 VBP denotes are
T19153 33439-33449 PRP denotes themselves
T19154 33450-33459 VBN denotes regulated
T19155 33460-33464 MD denotes will
T19156 33465-33467 VB denotes be
T19157 33468-33470 DT denotes an
T19158 33471-33480 JJ denotes important
T19159 33481-33489 NN denotes question
T19160 33490-33492 IN denotes in
T19161 33493-33498 NN denotes order
T19162 33499-33501 TO denotes to
T19163 33502-33509 VB denotes clarify
T19164 33510-33513 WRB denotes how
T19165 33514-33519 JJ denotes NF-κB
T19166 33520-33530 NN denotes signalling
T19167 33531-33533 VBZ denotes is
T19168 33534-33543 VBN denotes organised
T19169 33543-33544 , denotes ,
T19170 33545-33548 CC denotes and
T19171 33548-33549 , denotes ,
T19172 33550-33554 RBR denotes more
T19173 33555-33566 RB denotes importantly
T19174 33566-33567 , denotes ,
T19175 33568-33571 WRB denotes how
T19176 33572-33576 DT denotes this
T19177 33577-33586 NN denotes knowledge
T19178 33587-33590 MD denotes may
T19179 33591-33595 VB denotes lead
T19180 33596-33598 TO denotes to
T19181 33599-33602 JJ denotes new
T19182 33603-33613 NNS denotes treatments
T19183 33614-33617 IN denotes for
T19184 33618-33630 JJ denotes inflammatory
T19185 33631-33639 NNS denotes diseases
T19186 33640-33644 JJ denotes such
T19187 33645-33647 IN denotes as
T19188 33648-33650 NNP denotes RA
T19189 33650-33651 . denotes .
R100 T114 T115 amod Negative,regulation
R1000 T1185 T1184 prep in,Defects
R10000 T14978 T14975 appos ],loss
R10001 T14979 T14955 punct .,is
R10002 T14980 T14981 det These,findings
R10003 T14981 T14982 nsubj findings,suggest
R10004 T14982 T14982 ROOT suggest,suggest
R10005 T14983 T15001 mark that,indicate
R10006 T14984 T14985 amod CYLD-mediated,inhibi-tion
R10007 T14985 T15001 nsubj inhibi-tion,indicate
R10008 T14986 T14985 prep of,inhibi-tion
R10009 T14987 T14988 amod RANK-induced,NF-κB
R1001 T1227 T1224 punct ",",CD40
R10010 T14988 T14989 nsubj NF-κB,signalling
R10011 T14989 T14986 pcomp signalling,of
R10012 T14990 T14989 dobj plays,signalling
R10013 T14991 T14993 det a,role
R10014 T14992 T14993 amod key,role
R10015 T14993 T14989 oprd role,signalling
R10016 T14994 T14993 prep in,role
R10017 T14995 T14997 det the,regulation
R10018 T14996 T14997 amod negative,regulation
R10019 T14997 T14994 pobj regulation,in
R1002 T1228 T1224 appos TNFAIP3,CD40
R10020 T14998 T14997 prep of,regulation
R10021 T14999 T14998 pobj osteoclastogenesis,of
R10022 T15000 T14989 cc and,signalling
R10023 T15001 T14982 ccomp indicate,suggest
R10024 T15002 T15001 dobj CYLD,indicate
R10025 T15003 T15001 prep as,indicate
R10026 T15004 T15007 det a,factor
R10027 T15005 T15007 amod potential,factor
R10028 T15006 T15007 amod genetic,factor
R10029 T15007 T15003 pobj factor,as
R1003 T1229 T1224 punct ",",CD40
R10030 T15008 T15007 acl involved,factor
R10031 T15009 T15008 prep in,involved
R10032 T15010 T15011 det the,pathology
R10033 T15011 T15009 pobj pathology,in
R10034 T15012 T15011 prep of,pathology
R10035 T15013 T15014 compound bone,disorders
R10036 T15014 T15012 pobj disorders,of
R10037 T15015 T15016 amod such,as
R10038 T15016 T15014 prep as,disorders
R10039 T15017 T15016 pobj RA,as
R1004 T1186 T1187 det the,regulation
R10040 T15018 T14982 punct .,suggest
R1005 T1230 T1224 cc and,CD40
R1006 T1231 T1224 conj c-REL,CD40
R1007 T1232 T1231 punct ",",c-REL
R1008 T1187 T1185 pobj regulation,in
R1009 T1233 T1234 advmod further,highlight
R101 T115 T128 nsubj regulation,plays
R1010 T1234 T1221 appos highlight,signalling
R1011 T1188 T1187 prep of,regulation
R1012 T1235 T1236 det the,importance
R1013 T1236 T1234 dobj importance,highlight
R1014 T1237 T1236 prep of,importance
R1015 T1238 T1239 amod NF-κB,activation
R1016 T1239 T1237 pobj activation,of
R1017 T1240 T1239 prep in,activation
R1018 T1189 T1188 pobj osteoclastogenesis,of
R1019 T1241 T1243 nmod RA,[
R102 T116 T115 prep of,regulation
R1020 T1242 T1243 compound pathogenesis,[
R1021 T1243 T1240 pobj [,in
R1022 T1190 T1190 ROOT are,are
R1023 T1244 T1245 nummod 8,]
R1024 T1245 T1243 appos ],[
R1025 T1246 T1207 punct .,Finally
R1026 T1191 T1193 det the,cause
R1027 T1192 T1193 amod major,cause
R1028 T1193 T1190 attr cause,are
R1029 T1194 T1193 prep of,cause
R103 T117 T116 pobj NF-κB,of
R1030 T1195 T1196 compound bone,erosion
R1031 T1196 T1194 pobj erosion,of
R1032 T1197 T1196 prep in,erosion
R1033 T1198 T1199 amod osteolytic,diseases
R1034 T1199 T1197 pobj diseases,in
R1035 T1200 T1201 amod such,as
R1036 T1201 T1199 prep as,diseases
R1037 T1202 T1203 compound RA,[
R1038 T1203 T1201 pobj [,as
R1039 T1204 T1205 nummod 7,]
R104 T118 T117 cc and,NF-κB
R1040 T1205 T1203 conj ],[
R1041 T1206 T1190 punct .,are
R1042 T1207 T1207 ROOT Finally,Finally
R1043 T1208 T1210 punct ",",discoveries
R10438 T15830 T15847 nsubj Single-immunoglobulin,is
R10439 T15831 T15833 amod IL-1,protein
R1044 T1209 T1210 amod recent,discoveries
R10440 T15832 T15833 amod receptor-related,protein
R10441 T15833 T15847 nsubj protein,is
R10442 T15834 T15840 nmod Single-immunoglobulin,protein
R10443 T15835 T15836 compound IL-1,receptor-related
R10444 T15836 T15840 compound receptor-related,protein
R10445 T15837 T15838 punct (,SIGIRR
R10446 T15838 T15836 appos SIGIRR,receptor-related
R10447 T15839 T15838 punct ),SIGIRR
R10448 T15840 T15833 appos protein,protein
R10449 T15841 T15840 punct ",",protein
R1045 T1210 T1207 pobj discoveries,Finally
R10450 T15842 T15843 advmod also,known
R10451 T15843 T15833 acl known,protein
R10452 T15844 T15843 prep as,known
R10453 T15845 T15844 pobj TIR-8,as
R10454 T15846 T15833 punct ",",protein
R10455 T15847 T15847 ROOT is,is
R10456 T15848 T15849 det a,member
R10457 T15849 T15847 attr member,is
R10458 T15850 T15849 prep of,member
R10459 T15851 T15855 det the,family
R1046 T1211 T1210 acl revealing,discoveries
R10460 T15852 T15855 compound TLR/IL,family
R10461 T15853 T15854 nummod -1,R
R10462 T15854 T15855 compound R,family
R10463 T15855 T15850 pobj family,of
R10464 T15856 T15860 nsubjpass that,characterised
R10465 T15857 T15860 aux has,characterised
R10466 T15858 T15860 auxpass been,characterised
R10467 T15859 T15860 advmod extensively,characterised
R10468 T15860 T15855 relcl characterised,family
R10469 T15861 T15860 prep as,characterised
R1047 T1212 T1214 det a,association
R10470 T15862 T15863 det an,inhibitor
R10471 T15863 T15861 pobj inhibitor,as
R10472 T15864 T15863 prep of,inhibitor
R10473 T15865 T15864 pobj IL-1R,of
R10474 T15866 T15865 cc and,IL-1R
R10475 T15867 T15868 compound TLR,signalling
R10476 T15868 T15865 conj signalling,IL-1R
R10477 T15869 T15847 punct ",",is
R10478 T15870 T15871 advmod probably,through
R10479 T15871 T15847 prep through,is
R1048 T1213 T1214 amod genetic,association
R10480 T15872 T15873 amod direct,interaction
R10481 T15873 T15871 pobj interaction,through
R10482 T15874 T15873 prep with,interaction
R10483 T15875 T15876 det these,receptors
R10484 T15876 T15874 pobj receptors,with
R10485 T15877 T15873 punct ",",interaction
R10486 T15878 T15873 conj MyD88,interaction
R10487 T15879 T15878 punct ",",MyD88
R10488 T15880 T15878 conj IRAK1,MyD88
R10489 T15881 T15880 cc or,IRAK1
R1049 T1214 T1211 dobj association,revealing
R10490 T15882 T15883 compound TRAF6,[
R10491 T15883 T15880 conj [,IRAK1
R10492 T15884 T15885 nummod 67,]
R10493 T15885 T15880 conj ],IRAK1
R10494 T15886 T15887 punct (,Figure
R10495 T15887 T15885 appos Figure,]
R10496 T15888 T15887 nummod 1,Figure
R10497 T15889 T15887 punct ),Figure
R10498 T15890 T15847 punct .,is
R10499 T15891 T15904 prep Given,observed
R105 T119 T120 poss its,involvement
R1050 T1215 T1214 prep with,association
R10500 T15892 T15894 det the,role
R10501 T15893 T15894 amod important,role
R10502 T15894 T15891 pobj role,Given
R10503 T15895 T15894 prep of,role
R10504 T15896 T15895 pobj IL-1R,of
R10505 T15897 T15896 cc and,IL-1R
R10506 T15898 T15896 conj TLR,IL-1R
R10507 T15899 T15894 acl signalling,role
R10508 T15900 T15899 prep in,signalling
R10509 T15901 T15903 det the,inflammation
R1051 T1216 T1217 amod several,genes
R10510 T15902 T15903 amod chronic,inflammation
R10511 T15903 T15900 pobj inflammation,in
R10512 T15904 T15904 ROOT observed,observed
R10513 T15905 T15904 prep in,observed
R10514 T15906 T15907 compound RA,[
R10515 T15907 T15905 pobj [,in
R10516 T15908 T15909 nummod 68,]
R10517 T15909 T15918 nsubj ],is
R10518 T15910 T15909 punct ",",]
R10519 T15911 T15913 det a,role
R1052 T1217 T1215 pobj genes,with
R10520 T15912 T15913 amod regulatory,role
R10521 T15913 T15909 appos role,]
R10522 T15914 T15913 prep for,role
R10523 T15915 T15914 pobj SIGIRR,for
R10524 T15916 T15913 prep in,role
R10525 T15917 T15916 pobj RA,in
R10526 T15918 T15904 ccomp is,observed
R10527 T15919 T15918 neg not,is
R10528 T15920 T15918 acomp unlikely,is
R10529 T15921 T15904 punct .,observed
R1053 T1218 T1217 amod relevant,genes
R10530 T15922 T15923 nsubj SIGIRR,has
R10531 T15923 T15923 ROOT has,has
R10532 T15924 T15928 det a,pattern
R10533 T15925 T15926 advmod very,restricted
R10534 T15926 T15928 amod restricted,pattern
R10535 T15927 T15928 compound expression,pattern
R10536 T15928 T15923 dobj pattern,has
R10537 T15929 T15928 punct ",",pattern
R10538 T15930 T15931 auxpass being,expressed
R10539 T15931 T15928 acl expressed,pattern
R1054 T1219 T1218 prep to,relevant
R10540 T15932 T15931 prep in,expressed
R10541 T15933 T15934 amod epithelial,cells
R10542 T15934 T15932 pobj cells,in
R10543 T15935 T15934 punct ",",cells
R10544 T15936 T15934 conj monocytes,cells
R10545 T15937 T15936 cc and,monocytes
R10546 T15938 T15940 amod immature,cells
R10547 T15939 T15940 amod dendritic,cells
R10548 T15940 T15936 conj cells,monocytes
R10549 T15941 T15931 punct ",",expressed
R1055 T1220 T1221 amod NF-κB,signalling
R10550 T15942 T15931 cc but,expressed
R10551 T15943 T15944 neg not,in
R10552 T15944 T15923 prep in,has
R10553 T15945 T15946 amod mature,macro-phages
R10554 T15946 T15944 pobj macro-phages,in
R10555 T15947 T15949 compound [,]
R10556 T15948 T15949 compound "69,70",]
R10557 T15949 T15944 conj ],in
R10558 T15950 T15923 punct .,has
R10559 T15951 T15956 advmod Recently,shown
R1056 T1221 T1219 pobj signalling,to
R10560 T15952 T15956 punct ",",shown
R10561 T15953 T15954 compound SIGIRR,overexpression
R10562 T15954 T15956 nsubjpass overexpression,shown
R10563 T15955 T15956 auxpass was,shown
R10564 T15956 T15956 ROOT shown,shown
R10565 T15957 T15958 aux to,inhibit
R10566 T15958 T15956 xcomp inhibit,shown
R10567 T15959 T15961 det the,release
R10568 T15960 T15961 amod spontaneous,release
R10569 T15961 T15958 dobj release,inhibit
R10570 T15962 T15961 prep of,release
R10571 T15963 T15964 amod inflammatory,cytokines
R10572 T15964 T15962 pobj cytokines,of
R10573 T15965 T15961 prep by,release
R10574 T15966 T15969 amod human,cells
R10575 T15967 T15969 nmod RA,cells
R10576 T15968 T15969 amod synovial,cells
R10577 T15969 T15965 pobj cells,by
R10578 T15970 T15956 punct .,shown
R10579 T15971 T15973 det This,function
R10580 T15972 T15973 amod inhibitory,function
R10581 T15973 T15978 nsubjpass function,confirmed
R10582 T15974 T15973 prep of,function
R10583 T15975 T15974 pobj SIGIRR,of
R10584 T15976 T15978 auxpass was,confirmed
R10585 T15977 T15978 advmod further,confirmed
R10586 T15978 T15978 ROOT confirmed,confirmed
R10587 T15979 T15978 prep in,confirmed
R10588 T15980 T15979 pobj vivo,in
R10589 T15981 T15978 punct ",",confirmed
R10590 T15982 T15985 mark since,developed
R10591 T15983 T15984 amod SIGIRR-deficient,mice
R10592 T15984 T15985 nsubj mice,developed
R10593 T15985 T15978 advcl developed,confirmed
R10594 T15986 T15989 det a,disease
R10595 T15987 T15988 advmod more,severe
R10596 T15988 T15989 amod severe,disease
R10597 T15989 T15985 dobj disease,developed
R10598 T15990 T15989 prep in,disease
R10599 T15991 T15992 amod zymosan-induced,arthritis
R106 T120 T115 appos involvement,regulation
R10600 T15992 T15990 pobj arthritis,in
R10601 T15993 T15989 punct ",",disease
R10602 T15994 T15996 advmod as,as
R10603 T15995 T15996 advmod well,as
R10604 T15996 T15989 cc as,disease
R10605 T15997 T16000 amod collagen-induced,models
R10606 T15998 T15999 compound arthritis,mouse
R10607 T15999 T16000 compound mouse,models
R10608 T16000 T15989 conj models,disease
R10609 T16001 T16001 ROOT [,[
R10610 T16002 T16003 nummod 70,]
R10611 T16003 T16003 ROOT ],]
R10612 T16004 T15978 punct .,confirmed
R10613 T16005 T16007 nsubj It,be
R10614 T16006 T16007 aux will,be
R10615 T16007 T16007 ROOT be,be
R10616 T16008 T16007 acomp interesting,be
R10617 T16009 T16010 aux to,compare
R10618 T16010 T16007 xcomp compare,be
R10619 T16011 T16012 det the,expression
R10620 T16012 T16010 dobj expression,compare
R10621 T16013 T16012 prep of,expression
R10622 T16014 T16013 pobj SIGIRR,of
R10623 T16015 T16010 prep in,compare
R10624 T16016 T16017 compound RA,patients
R10625 T16017 T16015 pobj patients,in
R10626 T16018 T16010 prep with,compare
R10627 T16019 T16020 poss its,expression
R10628 T16020 T16018 pobj expression,with
R10629 T16021 T16020 prep in,expression
R10630 T16022 T16023 compound control,patients
R10631 T16023 T16021 pobj patients,in
R10632 T16024 T16020 punct ",",expression
R10633 T16025 T16010 cc or,compare
R10634 T16026 T16027 aux to,investigate
R10635 T16027 T16010 conj investigate,compare
R10636 T16028 T16034 mark whether,compromised
R10637 T16029 T16030 det the,function
R10638 T16030 T16034 nsubjpass function,compromised
R10639 T16031 T16030 prep of,function
R10640 T16032 T16031 pobj SIGIRR,of
R10641 T16033 T16034 auxpass is,compromised
R10642 T16034 T16027 ccomp compromised,investigate
R10643 T16035 T16034 prep in,compromised
R10644 T16036 T16037 compound RA,patients
R10645 T16037 T16035 pobj patients,in
R10646 T16038 T16007 punct .,be
R10647 T16039 T16049 prep Because,be
R10648 T16040 T16039 pcomp of,Because
R10649 T16041 T16044 poss its,pattern
R10650 T16042 T16044 amod restricted,pattern
R10651 T16043 T16044 compound expression,pattern
R10652 T16044 T16039 pobj pattern,Because
R10653 T16045 T16049 punct ",",be
R10654 T16046 T16049 nsubj SIGIRR,be
R10655 T16047 T16049 aux may,be
R10656 T16048 T16049 advmod also,be
R10657 T16049 T16049 ROOT be,be
R10658 T16050 T16053 det an,target
R10659 T16051 T16053 amod interesting,target
R10660 T16052 T16053 amod therapeutic,target
R10661 T16053 T16049 attr target,be
R10662 T16054 T16049 prep in,be
R10663 T16055 T16054 pobj RA,in
R10664 T16056 T16049 punct .,be
R107 T121 T120 prep in,involvement
R108 T122 T123 amod rheumatoid,arthritis
R109 T123 T121 pobj arthritis,in
R110 T124 T126 det The,factor
R11024 T16746 T16748 nmod TNF,factor
R11025 T16747 T16748 amod receptor-associated,factor
R11026 T16748 T16751 nsubj factor,is
R11027 T16749 T16748 nummod 1,factor
R11028 T16750 T16748 nummod TRAF1,factor
R11029 T16751 T16751 ROOT is,is
R11030 T16752 T16754 det a,member
R11031 T16753 T16754 amod unique,member
R11032 T16754 T16751 attr member,is
R11033 T16755 T16754 prep of,member
R11034 T16756 T16759 det the,family
R11035 T16757 T16759 compound TRAF,family
R11036 T16758 T16759 compound protein,family
R11037 T16759 T16755 pobj family,of
R11038 T16760 T16762 mark because,lacks
R11039 T16761 T16762 nsubj it,lacks
R11040 T16762 T16751 advcl lacks,is
R11041 T16763 T16766 det a,domain
R11042 T16764 T16766 compound RING,domain
R11043 T16765 T16766 compound finger,domain
R11044 T16766 T16762 dobj domain,lacks
R11045 T16767 T16762 cc and,lacks
R11046 T16768 T16769 advmod therefore,lacks
R11047 T16769 T16762 conj lacks,lacks
R11048 T16770 T16772 amod ubiquitin,activity
R11049 T16771 T16772 compound ligase,activity
R11050 T16772 T16769 dobj activity,lacks
R11051 T16773 T16751 punct .,is
R11052 T16774 T16774 ROOT Accumulating,Accumulating
R11053 T16775 T16776 nsubj data,support
R11054 T16776 T16774 dobj support,Accumulating
R11055 T16777 T16778 det a,role
R11056 T16778 T16776 dobj role,support
R11057 T16779 T16778 prep for,role
R11058 T16780 T16779 pobj TRAF1,for
R11059 T16781 T16776 prep as,support
R11060 T16782 T16784 det both,negative
R11061 T16783 T16784 det a,negative
R11062 T16784 T16781 pobj negative,as
R11063 T16785 T16784 cc and,negative
R11064 T16786 T16788 det a,modulator
R11065 T16787 T16788 amod positive,modulator
R11066 T16788 T16784 conj modulator,negative
R11067 T16789 T16788 prep of,modulator
R11068 T16790 T16791 amod NF-κB,signalling
R11069 T16791 T16789 pobj signalling,of
R11070 T16792 T16791 prep by,signalling
R11071 T16793 T16796 amod certain,receptors
R11072 T16794 T16796 compound TNF,receptors
R11073 T16795 T16796 compound family,receptors
R11074 T16796 T16792 pobj receptors,by
R11075 T16797 T16796 punct ",",receptors
R11076 T16798 T16799 advmod possibly,in
R11077 T16799 T16788 prep in,modulator
R11078 T16800 T16802 det a,manner
R11079 T16801 T16802 amod cell-type-dependent,manner
R11080 T16802 T16799 pobj manner,in
R11081 T16803 T16805 compound [,]
R11082 T16804 T16805 compound "71,72",]
R11083 T16805 T16802 appos ],manner
R11084 T16806 T16776 punct .,support
R11085 T16807 T16810 nsubj Expression,is
R11086 T16808 T16807 prep of,Expression
R11087 T16809 T16808 pobj TRAF1,of
R11088 T16810 T16810 ROOT is,is
R11089 T16811 T16810 acomp inducible,is
R11090 T16812 T16811 prep by,inducible
R11091 T16813 T16812 pobj TNF,by
R11092 T16814 T16813 cc and,TNF
R11093 T16815 T16813 conj overexpression,TNF
R11094 T16816 T16815 prep of,overexpression
R11095 T16817 T16818 nummod TRAF1,inhibits
R11096 T16818 T16816 pobj inhibits,of
R11097 T16819 T16821 nmod TNF-induced,activation
R11098 T16820 T16821 compound NF-κB,activation
R11099 T16821 T16815 conj activation,overexpression
R111 T125 T126 compound transcription,factor
R11100 T16822 T16810 punct .,is
R11101 T16823 T16825 amod TRAF1-deficient,cells
R11102 T16824 T16825 compound T,cells
R11103 T16825 T16826 nsubj cells,are
R11104 T16826 T16826 ROOT are,are
R11105 T16827 T16826 acomp hyper-responsive,are
R11106 T16828 T16827 prep to,hyper-responsive
R11107 T16829 T16828 pobj TNF,to
R11108 T16830 T16826 punct ",",are
R11109 T16831 T16826 prep with,are
R11110 T16832 T16833 amod enhanced,proliferation
R11111 T16833 T16831 pobj proliferation,with
R11112 T16834 T16833 cc and,proliferation
R11113 T16835 T16833 conj activation,proliferation
R11114 T16836 T16833 prep of,proliferation
R11115 T16837 T16840 det the,pathway
R11116 T16838 T16840 amod NF-κB,pathway
R11117 T16839 T16840 amod signalling,pathway
R11118 T16840 T16836 pobj pathway,of
R11119 T16841 T16826 punct .,are
R11120 T16842 T16844 nummod TRAF1,functions
R11121 T16843 T16844 advmod also,functions
R11122 T16844 T16844 ROOT functions,functions
R11123 T16845 T16844 prep as,functions
R11124 T16846 T16848 det a,regulator
R11125 T16847 T16848 amod negative,regulator
R11126 T16848 T16845 pobj regulator,as
R11127 T16849 T16848 prep of,regulator
R11128 T16850 T16852 amod CD40-induced,activation
R11129 T16851 T16852 compound NF-κB,activation
R11130 T16852 T16849 pobj activation,of
R11131 T16853 T16844 punct .,functions
R11132 T16854 T16856 amod TRAF1-deficient,cells
R11133 T16855 T16856 amod dendritic,cells
R11134 T16856 T16860 nsubj cells,show
R11135 T16857 T16860 punct ",",show
R11136 T16858 T16860 advmod however,show
R11137 T16859 T16860 punct ",",show
R11138 T16860 T16860 ROOT show,show
R11139 T16861 T16862 amod attenuated,responses
R11140 T16862 T16860 dobj responses,show
R11141 T16863 T16862 prep to,responses
R11142 T16864 T16865 amod secondary,stimulation
R11143 T16865 T16863 pobj stimulation,to
R11144 T16866 T16862 prep by,responses
R11145 T16867 T16868 amod TRAF2-dependent,factors
R11146 T16868 T16866 pobj factors,by
R11147 T16869 T16862 punct ",",responses
R11148 T16870 T16860 advcl suggesting,show
R11149 T16871 T16874 det a,role
R11150 T16872 T16874 amod positive,role
R11151 T16873 T16874 amod regulatory,role
R11152 T16874 T16870 dobj role,suggesting
R11153 T16875 T16874 prep in,role
R11154 T16876 T16877 det these,cells
R11155 T16877 T16875 pobj cells,in
R11156 T16878 T16860 punct .,show
R11157 T16879 T16880 det The,mechanism
R11158 T16880 T16889 nsubj mechanism,is
R11159 T16881 T16884 prep by,modulates
R11160 T16882 T16881 pobj which,by
R11161 T16883 T16884 nsubj TRAF1,modulates
R11162 T16884 T16880 relcl modulates,mechanism
R11163 T16885 T16884 punct NF,modulates
R11164 T16886 T16880 punct -,mechanism
R11165 T16887 T16888 compound κB,activation
R11166 T16888 T16880 appos activation,mechanism
R11167 T16889 T16889 ROOT is,is
R11168 T16890 T16889 advmod still,is
R11169 T16891 T16889 acomp unclear,is
R11170 T16892 T16889 punct .,is
R11171 T16893 T16894 advmod Most,probably
R11172 T16894 T16897 advmod probably,competes
R11173 T16895 T16897 punct ",",competes
R11174 T16896 T16897 nsubj TRAF1,competes
R11175 T16897 T16897 ROOT competes,competes
R11176 T16898 T16897 prep with,competes
R11177 T16899 T16901 compound TRAF,members
R11178 T16900 T16901 compound family,members
R11179 T16901 T16898 pobj members,with
R11180 T16902 T16897 prep for,competes
R11181 T16903 T16902 amod binding,for
R11182 T16904 T16903 prep to,binding
R11183 T16905 T16906 det the,receptor
R11184 T16906 T16904 pobj receptor,to
R11185 T16907 T16906 cc or,receptor
R11186 T16908 T16910 amod other,proteins
R11187 T16909 T16910 amod signalling,proteins
R11188 T16910 T16906 conj proteins,receptor
R11189 T16911 T16897 punct .,competes
R11190 T16912 T16916 advmod Alternatively,recruit
R11191 T16913 T16916 punct ",",recruit
R11192 T16914 T16916 nsubj TRAF1,recruit
R11193 T16915 T16916 aux might,recruit
R11194 T16916 T16916 ROOT recruit,recruit
R11195 T16917 T16916 dobj A20,recruit
R11196 T16918 T16923 prep with,interact
R11197 T16919 T16918 pobj which,with
R11198 T16920 T16923 nsubj it,interact
R11199 T16921 T16923 aux can,interact
R112 T126 T128 nsubj factor,plays
R11200 T16922 T16923 advmod physically,interact
R11201 T16923 T16916 conj interact,recruit
R11202 T16924 T16923 dobj [,interact
R11203 T16925 T16926 nummod 73,]
R11204 T16926 T16924 appos ],[
R11205 T16927 T16916 punct .,recruit
R11206 T16928 T16931 det A,study
R11207 T16929 T16930 compound genome-wide,association
R11208 T16930 T16931 compound association,study
R11209 T16931 T16946 nsubj study,identified
R11210 T16932 T16931 acl examining,study
R11211 T16933 T16935 amod more,"300,000"
R11212 T16934 T16935 quantmod than,"300,000"
R11213 T16935 T16936 nummod "300,000",SNPs
R11214 T16936 T16932 dobj SNPs,examining
R11215 T16937 T16932 prep among,examining
R11216 T16938 T16939 advmod approximately,"1,500"
R11217 T16939 T16942 nummod "1,500",cases
R11218 T16940 T16942 amod autoantibody-positive,cases
R11219 T16941 T16942 compound RA,cases
R11220 T16942 T16937 pobj cases,among
R11221 T16943 T16942 cc and,cases
R11222 T16944 T16945 nummod "1,800",controls
R11223 T16945 T16942 conj controls,cases
R11224 T16946 T16946 ROOT identified,identified
R11225 T16947 T16949 det a,variation
R11226 T16948 T16949 amod genetic,variation
R11227 T16949 T16946 dobj variation,identified
R11228 T16950 T16946 prep at,identified
R11229 T16951 T16953 det the,component
R11230 T16952 T16953 compound TRAF1-complement,component
R11231 T16953 T16950 pobj component,at
R11232 T16954 T16955 nummod 5,locus
R11233 T16955 T16946 npadvmod locus,identified
R11234 T16956 T16961 mark as,locus
R11235 T16957 T16960 det an,risk
R11236 T16958 T16960 amod important,risk
R11237 T16959 T16960 compound RA,risk
R11238 T16960 T16961 nsubj risk,locus
R11239 T16961 T16946 advcl locus,identified
R11240 T16962 T16964 nmod [,]
R11241 T16963 T16964 nummod 74,]
R11242 T16964 T16961 dobj ],locus
R11243 T16965 T16946 punct .,identified
R11244 T16966 T16967 amod Subsequent,work
R11245 T16967 T16968 nsubj work,indicates
R11246 T16968 T16968 ROOT indicates,indicates
R11247 T16969 T16971 mark that,is
R11248 T16970 T16971 nsubj TRAF1,is
R11249 T16971 T16968 ccomp is,indicates
R11250 T16972 T16973 advmod more,likely
R11251 T16973 T16971 acomp likely,is
R11252 T16974 T16975 aux to,be
R11253 T16975 T16973 xcomp be,likely
R11254 T16976 T16978 det the,locus
R11255 T16977 T16978 amod causative,locus
R11256 T16978 T16975 attr locus,be
R11257 T16979 T16981 nmod [,]
R11258 T16980 T16981 nummod 75,]
R11259 T16981 T16978 appos ],locus
R11260 T16982 T16968 punct .,indicates
R11261 T16983 T16984 amod Recent,work
R11262 T16984 T16990 nsubj work,demonstrates
R11263 T16985 T16984 prep in,work
R11264 T16986 T16988 det a,population
R11265 T16987 T16988 amod Korean,population
R11266 T16988 T16985 pobj population,in
R11267 T16989 T16990 advmod also,demonstrates
R11268 T16990 T16990 ROOT demonstrates,demonstrates
R11269 T16991 T16992 amod genetic,association
R11270 T16992 T16990 dobj association,demonstrates
R11271 T16993 T16992 prep of,association
R11272 T16994 T16996 det the,region
R11273 T16995 T16996 nummod TRAF1,region
R11274 T16996 T16993 pobj region,of
R11275 T16997 T16990 prep with,demonstrates
R11276 T16998 T16999 compound RA,[
R11277 T16999 T16997 pobj [,with
R11278 T17000 T17001 nummod 76,]
R11279 T17001 T16999 appos ],[
R11280 T17002 T16990 punct .,demonstrates
R113 T127 T128 nsubj NF-κB,plays
R114 T128 T128 ROOT plays,plays
R115 T129 T130 amod crucial,roles
R116 T130 T128 dobj roles,plays
R117 T131 T128 prep in,plays
R118 T132 T133 det the,regulation
R11895 T18039 T18040 compound microRNAs,miRNAs
R11896 T18040 T18043 nsubjpass miRNAs,discovered
R11897 T18041 T18043 auxpass are,discovered
R11898 T18042 T18043 advmod recently,discovered
R11899 T18043 T18043 ROOT discovered,discovered
R119 T133 T131 pobj regulation,in
R11900 T18044 T18043 dobj regulators,discovered
R11901 T18045 T18044 prep of,regulators
R11902 T18046 T18047 compound gene,expression
R11903 T18047 T18045 pobj expression,of
R11904 T18048 T18043 cc and,discovered
R11905 T18049 T18043 conj represent,discovered
R11906 T18050 T18051 det a,class
R11907 T18051 T18049 dobj class,represent
R11908 T18052 T18051 prep of,class
R11909 T18053 T18052 pcomp noncoding,of
R11910 T18054 T18055 compound RNA,molecules
R11911 T18055 T18053 dobj molecules,noncoding
R11912 T18056 T18051 amod essential,class
R11913 T18057 T18051 prep in,class
R11914 T18058 T18062 amod many,processes
R11915 T18059 T18062 amod cellular,processes
R11916 T18060 T18059 cc and,cellular
R11917 T18061 T18059 conj developmental,cellular
R11918 T18062 T18057 pobj processes,in
R11919 T18063 T18062 punct ",",processes
R11920 T18064 T18062 prep including,processes
R11921 T18065 T18066 amod immune,responses
R11922 T18066 T18064 pobj responses,including
R11923 T18067 T18066 cc and,responses
R11924 T18068 T18066 conj inflammation,responses
R11925 T18069 T18043 punct .,discovered
R11926 T18070 T18071 nsubj They,bind
R11927 T18071 T18071 ROOT bind,bind
R11928 T18072 T18073 det the,3
R11929 T18073 T18076 meta 3,UTR
R11930 T18074 T18073 punct ',3
R11931 T18075 T18076 punct -,UTR
R11932 T18076 T18071 dobj UTR,bind
R11933 T18077 T18076 prep of,UTR
R11934 T18078 T18079 compound target,mRNAs
R11935 T18079 T18077 pobj mRNAs,of
R11936 T18080 T18079 acl leading,mRNAs
R11937 T18081 T18080 prep to,leading
R11938 T18082 T18083 det the,repression
R11939 T18083 T18081 pobj repression,to
R11940 T18084 T18083 prep of,repression
R11941 T18085 T18086 compound protein,expression
R11942 T18086 T18084 pobj expression,of
R11943 T18087 T18086 cc and,expression
R11944 T18088 T18089 det the,promotion
R11945 T18089 T18086 conj promotion,expression
R11946 T18090 T18089 prep of,promotion
R11947 T18091 T18092 compound target,mRNA
R11948 T18092 T18093 compound mRNA,degradation
R11949 T18093 T18090 pobj degradation,of
R11950 T18094 T18096 nmod [,]
R11951 T18095 T18096 nummod 77,]
R11952 T18096 T18093 appos ],degradation
R11953 T18097 T18071 punct .,bind
R11954 T18098 T18100 amod miR-146a,b
R11955 T18099 T18100 compound /,b
R11956 T18100 T18103 nsubj b,are
R11957 T18101 T18100 cc and,b
R11958 T18102 T18100 conj miR-155,b
R11959 T18103 T18103 ROOT are,are
R11960 T18104 T18103 prep of,are
R11961 T18105 T18106 amod particular,interest
R11962 T18106 T18104 pobj interest,of
R11963 T18107 T18103 prep for,are
R11964 T18108 T18109 amod inflammatory,signalling
R11965 T18109 T18107 pobj signalling,for
R11966 T18110 T18109 prep to,signalling
R11967 T18111 T18110 pobj NF-κB,to
R11968 T18112 T18103 punct ",",are
R11969 T18113 T18118 mark since,induced
R11970 T18114 T18115 det these,miRNAs
R11971 T18115 T18118 nsubjpass miRNAs,induced
R11972 T18116 T18118 aux can,induced
R11973 T18117 T18118 auxpass be,induced
R11974 T18118 T18103 advcl induced,are
R11975 T18119 T18118 agent by,induced
R11976 T18120 T18121 amod inflammatory,stimuli
R11977 T18121 T18119 pobj stimuli,by
R11978 T18122 T18123 amod such,as
R11979 T18123 T18121 prep as,stimuli
R11980 T18124 T18123 pobj IL-1β,as
R11981 T18125 T18124 punct ",",IL-1β
R11982 T18126 T18124 conj TNF,IL-1β
R11983 T18127 T18126 cc and,TNF
R11984 T18128 T18129 compound TLRs,[
R11985 T18129 T18126 conj [,TNF
R11986 T18130 T18131 compound "78,79",]
R11987 T18131 T18126 conj ],TNF
R11988 T18132 T18103 punct .,are
R11989 T18133 T18137 prep In,is
R11990 T18134 T18133 pobj addition,In
R11991 T18135 T18137 punct ",",is
R11992 T18136 T18137 nsubj miR-146a,is
R11993 T18137 T18137 ROOT is,is
R11994 T18138 T18140 det an,gene
R11995 T18139 T18140 amod NF-κB-dependent,gene
R11996 T18140 T18137 attr gene,is
R11997 T18141 T18137 punct ",",is
R11998 T18142 T18137 cc and,is
R11999 T18143 T18144 det the,NF-κB
R120 T134 T133 prep of,regulation
R12000 T18144 T18145 nsubj NF-κB,signalling
R12001 T18145 T18151 advcl signalling,identified
R12002 T18146 T18145 dobj molecules,signalling
R12003 T18147 T18151 nsubjpass IRAK1,identified
R12004 T18148 T18147 cc and,IRAK1
R12005 T18149 T18147 conj TRAF6,IRAK1
R12006 T18150 T18151 auxpass were,identified
R12007 T18151 T18137 conj identified,is
R12008 T18152 T18151 prep as,identified
R12009 T18153 T18154 compound target,genes
R12010 T18154 T18152 pobj genes,as
R12011 T18155 T18154 prep of,genes
R12012 T18156 T18157 compound miR-146a,[
R12013 T18157 T18155 pobj [,of
R12014 T18158 T18159 nummod 78,]
R12015 T18159 T18154 conj ],genes
R12016 T18160 T18161 punct (,Figure
R12017 T18161 T18159 appos Figure,]
R12018 T18162 T18161 nummod 1,Figure
R12019 T18163 T18159 punct ),]
R12020 T18164 T18151 punct .,identified
R12021 T18165 T18169 advmod Similarly,shown
R12022 T18166 T18169 punct ",",shown
R12023 T18167 T18169 nsubjpass miR-155,shown
R12024 T18168 T18169 auxpass was,shown
R12025 T18169 T18169 ROOT shown,shown
R12026 T18170 T18171 aux to,target
R12027 T18171 T18169 xcomp target,shown
R12028 T18172 T18171 dobj transcripts,target
R12029 T18173 T18172 prep for,transcripts
R12030 T18174 T18175 det the,NF-κB
R12031 T18175 T18176 nsubj NF-κB,signalling
R12032 T18176 T18173 pcomp signalling,for
R12033 T18177 T18176 dobj molecules,signalling
R12034 T18178 T18176 dobj IKKε,signalling
R12035 T18179 T18178 cc and,IKKε
R12036 T18180 T18181 compound RIP1,[
R12037 T18181 T18178 conj [,IKKε
R12038 T18182 T18183 compound "79,80",]
R12039 T18183 T18178 conj ],IKKε
R12040 T18184 T18169 punct .,shown
R12041 T18185 T18192 advmod Notably,expressed
R12042 T18186 T18192 punct ",",expressed
R12043 T18187 T18188 preconj both,miR-146
R12044 T18188 T18192 nsubjpass miR-146,expressed
R12045 T18189 T18188 cc and,miR-146
R12046 T18190 T18188 conj miR-155,miR-146
R12047 T18191 T18192 auxpass are,expressed
R12048 T18192 T18192 ROOT expressed,expressed
R12049 T18193 T18192 prep at,expressed
R12050 T18194 T18195 amod higher,levels
R12051 T18195 T18193 pobj levels,at
R12052 T18196 T18195 prep in,levels
R12053 T18197 T18196 pobj RA,in
R12054 T18198 T18199 amod synovial,fibroblasts
R12055 T18199 T18195 conj fibroblasts,levels
R12056 T18200 T18199 cc and,fibroblasts
R12057 T18201 T18202 amod synovial,tissue
R12058 T18202 T18205 compound tissue,]
R12059 T18203 T18205 compound [,]
R12060 T18204 T18205 compound "81,82",]
R12061 T18205 T18199 conj ],fibroblasts
R12062 T18206 T18205 punct ",",]
R12063 T18207 T18209 advmod as,as
R12064 T18208 T18209 advmod well,as
R12065 T18209 T18193 cc as,at
R12066 T18210 T18209 prep in,as
R12067 T18211 T18214 amod peripheral,cells
R12068 T18212 T18213 compound blood,mononuclear
R12069 T18213 T18214 compound mononuclear,cells
R12070 T18214 T18210 pobj cells,in
R12071 T18215 T18214 prep of,cells
R12072 T18216 T18217 compound RA,patients
R12073 T18217 T18215 pobj patients,of
R12074 T18218 T18220 nmod [,]
R12075 T18219 T18220 nummod 83,]
R12076 T18220 T18192 dobj ],expressed
R12077 T18221 T18192 punct .,expressed
R12078 T18222 T18225 nsubjpass miR-146a,overexpressed
R12079 T18223 T18225 auxpass is,overexpressed
R12080 T18224 T18225 advmod also,overexpressed
R12081 T18225 T18225 ROOT overexpressed,overexpressed
R12082 T18226 T18225 prep in,overexpressed
R12083 T18227 T18228 compound CD4,+
R12084 T18228 T18226 pobj +,in
R12085 T18229 T18228 cc and,+
R12086 T18230 T18228 conj IL-17-producing,+
R12087 T18231 T18232 compound T,cells
R12088 T18232 T18225 conj cells,overexpressed
R12089 T18233 T18232 prep from,cells
R12090 T18234 T18235 compound RA,patients
R12091 T18235 T18233 pobj patients,from
R12092 T18236 T18237 quantmod [,"84,85"
R12093 T18237 T18238 nummod "84,85",]
R12094 T18238 T18232 conj ],cells
R12095 T18239 T18225 punct .,overexpressed
R12096 T18240 T18257 advmod Interestingly,shown
R12097 T18241 T18257 punct ",",shown
R12098 T18242 T18243 det a,polymorphism
R12099 T18243 T18257 nsubjpass polymorphism,shown
R121 T135 T138 nmod inflammation,responses
R12100 T18244 T18243 prep in,polymorphism
R12101 T18245 T18249 det the,UTR
R12102 T18246 T18249 nummod 3,UTR
R12103 T18247 T18246 punct ',3
R12104 T18248 T18249 punct -,UTR
R12105 T18249 T18244 pobj UTR,in
R12106 T18250 T18249 prep of,UTR
R12107 T18251 T18254 det the,gene
R12108 T18252 T18254 compound miR-146a,gene
R12109 T18253 T18254 compound target,gene
R12110 T18254 T18250 pobj gene,of
R12111 T18255 T18257 auxpass was,shown
R12112 T18256 T18257 advmod recently,shown
R12113 T18257 T18257 ROOT shown,shown
R12114 T18258 T18260 aux to,associated
R12115 T18259 T18260 auxpass be,associated
R12116 T18260 T18257 xcomp associated,shown
R12117 T18261 T18260 prep with,associated
R12118 T18262 T18263 compound RA,susceptibility
R12119 T18263 T18264 compound susceptibility,[
R12120 T18264 T18261 pobj [,with
R12121 T18265 T18266 nummod 86,]
R12122 T18266 T18264 appos ],[
R12123 T18267 T18257 punct .,shown
R12124 T18268 T18269 compound miR-155,overexpression
R12125 T18269 T18273 nsubj overexpression,was
R12126 T18270 T18269 prep in,overexpression
R12127 T18271 T18272 amod synovial,fibroblasts
R12128 T18272 T18270 pobj fibroblasts,in
R12129 T18273 T18273 ROOT was,was
R12130 T18274 T18273 acomp able,was
R12131 T18275 T18276 aux to,prevent
R12132 T18276 T18274 xcomp prevent,able
R12133 T18277 T18278 det the,TLR
R12134 T18278 T18276 dobj TLR,prevent
R12135 T18279 T18278 cc and,TLR
R12136 T18280 T18281 amod cytokine-inducible,expression
R12137 T18281 T18278 conj expression,TLR
R12138 T18282 T18281 prep of,expression
R12139 T18283 T18285 amod specific,metalloproteinases
R12140 T18284 T18285 compound matrix,metalloproteinases
R12141 T18285 T18282 pobj metalloproteinases,of
R12142 T18286 T18287 nsubj that,mediate
R12143 T18287 T18285 relcl mediate,metalloproteinases
R12144 T18288 T18289 amod tissue,destruction
R12145 T18289 T18287 dobj destruction,mediate
R12146 T18290 T18287 prep in,mediate
R12147 T18291 T18292 compound RA,[
R12148 T18292 T18290 pobj [,in
R12149 T18293 T18294 nummod 81,]
R12150 T18294 T18292 appos ],[
R12151 T18295 T18273 punct .,was
R12152 T18296 T18300 advmod Moreover,shown
R12153 T18297 T18300 punct ",",shown
R12154 T18298 T18300 nsubjpass miR-155,shown
R12155 T18299 T18300 auxpass was,shown
R12156 T18300 T18300 ROOT shown,shown
R12157 T18301 T18302 aux to,promote
R12158 T18302 T18300 xcomp promote,shown
R12159 T18303 T18304 compound TNF,production
R12160 T18304 T18302 dobj production,promote
R12161 T18305 T18304 punct ",",production
R12162 T18306 T18308 det a,process
R12163 T18307 T18308 amod key,process
R12164 T18308 T18304 appos process,production
R12165 T18309 T18308 prep in,process
R12166 T18310 T18311 det the,pathogenesis
R12167 T18311 T18309 pobj pathogenesis,in
R12168 T18312 T18311 prep of,pathogenesis
R12169 T18313 T18314 compound RA,[
R12170 T18314 T18312 pobj [,of
R12171 T18315 T18316 nummod 87,]
R12172 T18316 T18311 appos ],pathogenesis
R12173 T18317 T18300 punct .,shown
R12174 T18318 T18323 nsubj miR-146,be
R12175 T18319 T18318 cc and,miR-146
R12176 T18320 T18318 conj miR-155,miR-146
R12177 T18321 T18323 aux may,be
R12178 T18322 T18323 advmod therefore,be
R12179 T18323 T18323 ROOT be,be
R12180 T18324 T18326 amod important,regulators
R12181 T18325 T18326 amod negative,regulators
R12182 T18326 T18323 attr regulators,be
R12183 T18327 T18326 prep of,regulators
R12184 T18328 T18327 pobj inflammation,of
R12185 T18329 T18328 prep in,inflammation
R12186 T18330 T18329 pobj RA,in
R12187 T18331 T18323 cc and,be
R12188 T18332 T18333 poss their,potential
R12189 T18333 T18340 nsubj potential,is
R12190 T18334 T18333 prep for,potential
R12191 T18335 T18336 det the,development
R12192 T18336 T18334 pobj development,for
R12193 T18337 T18336 prep of,development
R12194 T18338 T18339 amod new,treatments
R12195 T18339 T18337 pobj treatments,of
R12196 T18340 T18323 conj is,be
R12197 T18341 T18340 acomp substantial,is
R12198 T18342 T18340 punct .,is
R12199 T18343 T18352 prep In,is
R122 T136 T135 cc and,inflammation
R12200 T18344 T18343 pobj addition,In
R12201 T18345 T18352 punct ",",is
R12202 T18346 T18348 poss their,expression
R12203 T18347 T18348 amod increased,expression
R12204 T18348 T18352 nsubj expression,is
R12205 T18349 T18348 prep in,expression
R12206 T18350 T18351 compound RA,patients
R12207 T18351 T18349 pobj patients,in
R12208 T18352 T18352 ROOT is,is
R12209 T18353 T18354 advmod potentially,useful
R12210 T18354 T18352 acomp useful,is
R12211 T18355 T18354 prep as,useful
R12212 T18356 T18357 det a,marker
R12213 T18357 T18355 pobj marker,as
R12214 T18358 T18357 prep for,marker
R12215 T18359 T18360 compound disease,diagnosis
R12216 T18360 T18358 pobj diagnosis,for
R12217 T18361 T18360 punct ",",diagnosis
R12218 T18362 T18360 conj progression,diagnosis
R12219 T18363 T18362 punct ",",progression
R12220 T18364 T18362 cc or,progression
R12221 T18365 T18366 compound treatment,efficacy
R12222 T18366 T18362 conj efficacy,progression
R12223 T18367 T18369 nmod [,]
R12224 T18368 T18369 nummod 88,]
R12225 T18369 T18357 appos ],marker
R12226 T18370 T18352 punct ",",is
R12227 T18371 T18352 cc but,is
R12228 T18372 T18374 nsubj this,require
R12229 T18373 T18374 aux will,require
R12230 T18374 T18352 conj require,is
R12231 T18375 T18374 dobj confirmation,require
R12232 T18376 T18374 advcl using,require
R12233 T18377 T18381 det a,cohort
R12234 T18378 T18381 amod large,cohort
R12235 T18379 T18378 cc and,large
R12236 T18380 T18378 conj well-defined,large
R12237 T18381 T18376 dobj cohort,using
R12238 T18382 T18374 punct .,require
R12239 T18383 T18409 prep Besides,identified
R12240 T18384 T18383 pobj miR-146,Besides
R12241 T18385 T18384 cc and,miR-146
R12242 T18386 T18384 conj miR-155,miR-146
R12243 T18387 T18386 punct ",",miR-155
R12244 T18388 T18389 det a,number
R12245 T18389 T18386 appos number,miR-155
R12246 T18390 T18389 prep of,number
R12247 T18391 T18392 amod other,miRNAs
R12248 T18392 T18390 pobj miRNAs,of
R12249 T18393 T18389 prep with,number
R12250 T18394 T18396 det a,role
R12251 T18395 T18396 amod potential,role
R12252 T18396 T18393 pobj role,with
R12253 T18397 T18396 prep in,role
R12254 T18398 T18399 det the,control
R12255 T18399 T18397 pobj control,in
R12256 T18400 T18399 prep of,control
R12257 T18401 T18403 amod NF-κB-dependent,responses
R12258 T18402 T18403 amod inflammatory,responses
R12259 T18403 T18400 pobj responses,of
R12260 T18404 T18403 prep in,responses
R12261 T18405 T18406 compound RA,pathology
R12262 T18406 T18404 pobj pathology,in
R12263 T18407 T18409 auxpass were,identified
R12264 T18408 T18409 advmod recently,identified
R12265 T18409 T18409 ROOT identified,identified
R12266 T18410 T18409 punct .,identified
R12267 T18411 T18411 ROOT In,In
R12268 T18412 T18413 det this,context
R12269 T18413 T18411 pobj context,In
R12270 T18414 T18411 punct ",",In
R12271 T18415 T18411 conj miR-124a,In
R12272 T18416 T18415 punct -,miR-124a
R12273 T18417 T18419 det a,regulator
R12274 T18418 T18419 amod key,regulator
R12275 T18419 T18415 appos regulator,miR-124a
R12276 T18420 T18419 prep of,regulator
R12277 T18421 T18425 det the,protein
R12278 T18422 T18425 nmod chemokine,protein
R12279 T18423 T18425 nmod monocyte,protein
R12280 T18424 T18425 compound chemoattractant,protein
R12281 T18425 T18420 pobj protein,of
R12282 T18426 T18429 meta 1,shown
R12283 T18427 T18429 punct -,shown
R12284 T18428 T18429 auxpass was,shown
R12285 T18429 T18429 ROOT shown,shown
R12286 T18430 T18432 aux to,decreased
R12287 T18431 T18432 auxpass be,decreased
R12288 T18432 T18429 xcomp decreased,shown
R12289 T18433 T18432 prep in,decreased
R12290 T18434 T18433 pobj synoviocytes,in
R12291 T18435 T18434 prep from,synoviocytes
R12292 T18436 T18437 compound RA,patients
R12293 T18437 T18435 pobj patients,from
R12294 T18438 T18440 nmod [,]
R12295 T18439 T18440 nummod 89,]
R12296 T18440 T18437 appos ],patients
R12297 T18441 T18429 punct .,shown
R12298 T18442 T18460 advmod Similarly,detected
R12299 T18443 T18460 punct ",",detected
R123 T137 T135 conj mmune,inflammation
R12300 T18444 T18445 amod elevated,levels
R12301 T18445 T18460 nsubjpass levels,detected
R12302 T18446 T18445 prep of,levels
R12303 T18447 T18446 pobj miR-203,of
R12304 T18448 T18449 punct -,leading
R12305 T18449 T18445 acl leading,levels
R12306 T18450 T18449 prep to,leading
R12307 T18451 T18452 amod increased,secretion
R12308 T18452 T18450 pobj secretion,to
R12309 T18453 T18452 prep of,secretion
R12310 T18454 T18455 compound matrix,metalloproteinase-1
R12311 T18455 T18453 pobj metalloproteinase-1,of
R12312 T18456 T18455 cc and,metalloproteinase-1
R12313 T18457 T18455 conj IL-6,metalloproteinase-1
R12314 T18458 T18460 punct -,detected
R12315 T18459 T18460 auxpass were,detected
R12316 T18460 T18460 ROOT detected,detected
R12317 T18461 T18460 prep in,detected
R12318 T18462 T18464 nmod RA,fibroblasts
R12319 T18463 T18464 compound synovial,fibroblasts
R12320 T18464 T18465 compound fibroblasts,[
R12321 T18465 T18461 pobj [,in
R12322 T18466 T18467 nummod 90,]
R12323 T18467 T18465 appos ],[
R12324 T18468 T18460 punct .,detected
R12325 T18469 T18479 advmod Finally,shown
R12326 T18470 T18479 punct ",",shown
R12327 T18471 T18479 nsubjpass miR-16,shown
R12328 T18472 T18471 punct ",",miR-16
R12329 T18473 T18471 conj miR-132,miR-16
R12330 T18474 T18473 punct ",",miR-132
R12331 T18475 T18473 cc and,miR-132
R12332 T18476 T18473 conj miR-223,miR-132
R12333 T18477 T18479 auxpass were,shown
R12334 T18478 T18479 advmod also,shown
R12335 T18479 T18479 ROOT shown,shown
R12336 T18480 T18481 aux to,have
R12337 T18481 T18479 xcomp have,shown
R12338 T18482 T18484 det an,expression
R12339 T18483 T18484 amod altered,expression
R12340 T18484 T18481 dobj expression,have
R12341 T18485 T18484 prep in,expression
R12342 T18486 T18487 compound RA,patients
R12343 T18487 T18485 pobj patients,in
R12344 T18488 T18479 punct ",",shown
R12345 T18489 T18479 advcl indicating,shown
R12346 T18490 T18491 poss their,potential
R12347 T18491 T18489 dobj potential,indicating
R12348 T18492 T18491 prep as,potential
R12349 T18493 T18494 amod diagnostic,biomarkers
R12350 T18494 T18492 pobj biomarkers,as
R12351 T18495 T18494 prep for,biomarkers
R12352 T18496 T18495 pobj pathogenesis,for
R12353 T18497 T18499 compound [,]
R12354 T18498 T18499 compound "83,88,91",]
R12355 T18499 T18491 appos ],potential
R12356 T18500 T18479 punct .,shown
R124 T138 T134 pobj responses,of
R125 T139 T133 punct ",",regulation
R126 T140 T133 cc and,regulation
R12606 T19050 T19052 det The,family
R12607 T19051 T19052 compound NF-κB,family
R12608 T19052 T19056 nsubj family,plays
R12609 T19053 T19052 prep of,family
R12610 T19054 T19055 compound transcription,factors
R12611 T19055 T19053 pobj factors,of
R12612 T19056 T19056 ROOT plays,plays
R12613 T19057 T19058 amod crucial,roles
R12614 T19058 T19056 dobj roles,plays
R12615 T19059 T19056 prep in,plays
R12616 T19060 T19062 det the,processes
R12617 T19061 T19062 amod inflammatory,processes
R12618 T19062 T19059 pobj processes,in
R12619 T19063 T19062 prep in,processes
R12620 T19064 T19063 pobj RA,in
R12621 T19065 T19056 advcl leading,plays
R12622 T19066 T19065 prep to,leading
R12623 T19067 T19066 pobj cartilage,to
R12624 T19068 T19067 cc and,cartilage
R12625 T19069 T19070 compound bone,destruction
R12626 T19070 T19067 conj destruction,cartilage
R12627 T19071 T19056 punct .,plays
R12628 T19072 T19079 csubj Keeping,be
R12629 T19073 T19074 amod NF-κB,activation
R12630 T19074 T19072 dobj activation,Keeping
R12631 T19075 T19074 prep under,activation
R12632 T19076 T19075 pobj control,under
R12633 T19077 T19079 aux can,be
R12634 T19078 T19079 advmod thus,be
R12635 T19079 T19079 ROOT be,be
R12636 T19080 T19081 advmod very,important
R12637 T19081 T19079 acomp important,be
R12638 T19082 T19079 prep for,be
R12639 T19083 T19084 det the,design
R12640 T19084 T19082 pobj design,for
R12641 T19085 T19084 prep of,design
R12642 T19086 T19087 amod specific,therapeutics
R12643 T19087 T19085 pobj therapeutics,of
R12644 T19088 T19079 punct .,be
R12645 T19089 T19090 det The,existence
R12646 T19090 T19106 nsubj existence,raises
R12647 T19091 T19090 prep of,existence
R12648 T19092 T19094 amod multiple,regulators
R12649 T19093 T19094 amod negative,regulators
R12650 T19094 T19091 pobj regulators,of
R12651 T19095 T19090 acl ensuring,existence
R12652 T19096 T19098 det a,regulation
R12653 T19097 T19098 amod tight,regulation
R12654 T19098 T19095 dobj regulation,ensuring
R12655 T19099 T19098 prep of,regulation
R12656 T19100 T19102 det the,pathway
R12657 T19101 T19102 compound NF-κB,pathway
R12658 T19102 T19099 pobj pathway,of
R12659 T19103 T19098 punct ",",regulation
R12660 T19104 T19106 advmod however,raises
R12661 T19105 T19106 punct ",",raises
R12662 T19106 T19106 ROOT raises,raises
R12663 T19107 T19108 det the,question
R12664 T19108 T19106 dobj question,raises
R12665 T19109 T19108 prep of,question
R12666 T19110 T19112 det the,role
R12667 T19111 T19112 amod specific,role
R12668 T19112 T19109 pobj role,of
R12669 T19113 T19112 prep of,role
R12670 T19114 T19113 pobj each,of
R12671 T19115 T19114 prep of,each
R12672 T19116 T19117 det these,regulators
R12673 T19117 T19115 pobj regulators,of
R12674 T19118 T19114 cc and,each
R12675 T19119 T19120 det the,relationship
R12676 T19120 T19106 dobj relationship,raises
R12677 T19121 T19120 prep between,relationship
R12678 T19122 T19121 pobj them,between
R12679 T19123 T19106 punct .,raises
R12680 T19124 T19145 prep In,expected
R12681 T19125 T19124 pobj addition,In
R12682 T19126 T19145 punct ",",expected
R12683 T19127 T19145 prep given,expected
R12684 T19128 T19129 det the,number
R12685 T19129 T19127 pobj number,given
R12686 T19130 T19129 prep of,number
R12687 T19131 T19130 pobj miRNAs,of
R12688 T19132 T19131 prep in,miRNAs
R12689 T19133 T19132 pobj humans,in
R12690 T19134 T19129 cc and,number
R12691 T19135 T19137 det the,mRNAs
R12692 T19136 T19137 amod multiple,mRNAs
R12693 T19137 T19129 conj mRNAs,number
R12694 T19138 T19139 nsubj they,target
R12695 T19139 T19137 relcl target,mRNAs
R12696 T19140 T19145 punct ",",expected
R12697 T19141 T19142 amod intense,complexity
R12698 T19142 T19145 nsubjpass complexity,expected
R12699 T19143 T19145 aux can,expected
R127 T141 T143 amod inappropriate,activity
R12700 T19144 T19145 auxpass be,expected
R12701 T19145 T19145 ROOT expected,expected
R12702 T19146 T19145 punct .,expected
R12703 T19147 T19154 advmod How,regulated
R12704 T19148 T19151 predet all,signals
R12705 T19149 T19151 det these,signals
R12706 T19150 T19151 amod regulatory,signals
R12707 T19151 T19154 nsubjpass signals,regulated
R12708 T19152 T19154 auxpass are,regulated
R12709 T19153 T19154 npadvmod themselves,regulated
R12710 T19154 T19156 csubj regulated,be
R12711 T19155 T19156 aux will,be
R12712 T19156 T19156 ROOT be,be
R12713 T19157 T19159 det an,question
R12714 T19158 T19159 amod important,question
R12715 T19159 T19156 attr question,be
R12716 T19160 T19156 prep in,be
R12717 T19161 T19160 pobj order,in
R12718 T19162 T19163 aux to,clarify
R12719 T19163 T19161 acl clarify,order
R12720 T19164 T19167 advmod how,is
R12721 T19165 T19167 acomp NF-κB,is
R12722 T19166 T19167 nsubj signalling,is
R12723 T19167 T19163 ccomp is,clarify
R12724 T19168 T19167 attr organised,is
R12725 T19169 T19167 punct ",",is
R12726 T19170 T19167 cc and,is
R12727 T19171 T19167 punct ",",is
R12728 T19172 T19173 advmod more,importantly
R12729 T19173 T19179 advmod importantly,lead
R12730 T19174 T19179 punct ",",lead
R12731 T19175 T19179 advmod how,lead
R12732 T19176 T19177 det this,knowledge
R12733 T19177 T19179 nsubj knowledge,lead
R12734 T19178 T19179 aux may,lead
R12735 T19179 T19156 advcl lead,be
R12736 T19180 T19179 prep to,lead
R12737 T19181 T19182 amod new,treatments
R12738 T19182 T19180 pobj treatments,to
R12739 T19183 T19182 prep for,treatments
R12740 T19184 T19185 amod inflammatory,diseases
R12741 T19185 T19183 pobj diseases,for
R12742 T19186 T19187 amod such,as
R12743 T19187 T19185 prep as,diseases
R12744 T19188 T19187 pobj RA,as
R12745 T19189 T19156 punct .,be
R128 T142 T143 compound NF-κB,activity
R129 T143 T133 conj activity,regulation
R130 T144 T146 aux has,linked
R131 T145 T146 auxpass been,linked
R132 T146 T128 conj linked,plays
R13295 T20179 T20180 compound Canonical,NF-κB
R13296 T20180 T20181 nsubj NF-κB,signalling
R13297 T20181 T20181 ROOT signalling,signalling
R13298 T20182 T20181 cc and,signalling
R13299 T20183 T20184 amod negative,regulators
R133 T147 T146 prep with,linked
R13300 T20184 T20181 dobj regulators,signalling
R13301 T20185 T20181 punct .,signalling
R13302 T20186 T20187 compound Ligand,engagement
R13303 T20187 T20202 dep engagement,trigger
R13304 T20188 T20187 prep of,engagement
R13305 T20189 T20191 amod specific,receptors
R13306 T20190 T20191 compound membrane,receptors
R13307 T20191 T20188 pobj receptors,of
R13308 T20192 T20193 amod such,as
R13309 T20193 T20191 prep as,receptors
R13310 T20194 T20193 pobj TNFR1,as
R13311 T20195 T20194 punct ",",TNFR1
R13312 T20196 T20202 nsubj CD40,trigger
R13313 T20197 T20196 punct ",",CD40
R13314 T20198 T20196 conj RANK,CD40
R13315 T20199 T20198 punct ",",RANK
R13316 T20200 T20198 cc and,RANK
R13317 T20201 T20202 nummod TLR4,trigger
R13318 T20202 T20202 ROOT trigger,trigger
R13319 T20203 T20204 det the,recruitment
R13320 T20204 T20202 dobj recruitment,trigger
R13321 T20205 T20204 prep of,recruitment
R13322 T20206 T20208 amod specific,proteins
R13323 T20207 T20208 compound adaptor,proteins
R13324 T20208 T20205 pobj proteins,of
R13325 T20209 T20208 punct (,proteins
R13326 T20210 T20215 compound TNF,protein
R13327 T20211 T20215 compound receptor,protein
R13328 T20212 T20214 amod 1-associated,domain
R13329 T20213 T20214 compound death,domain
R13330 T20214 T20215 compound domain,protein
R13331 T20215 T20208 appos protein,proteins
R13332 T20216 T20217 punct (,TRADD
R13333 T20217 T20215 appos TRADD,protein
R13334 T20218 T20217 punct ),TRADD
R13335 T20219 T20215 punct ",",protein
R13336 T20220 T20215 appos MyD88,protein
R13337 T20221 T20220 punct ",",MyD88
R13338 T20222 T20220 conj MAL,MyD88
R13339 T20223 T20222 punct ",",MAL
R13340 T20224 T20227 compound TIR,IFNβ
R13341 T20225 T20227 compound domain-containing,IFNβ
R13342 T20226 T20227 compound adaptor-inducing,IFNβ
R13343 T20227 T20222 conj IFNβ,MAL
R13344 T20228 T20229 punct (,TRIF
R13345 T20229 T20227 appos TRIF,IFNβ
R13346 T20230 T20229 punct ),TRIF
R13347 T20231 T20227 punct ),IFNβ
R13348 T20232 T20227 punct ",",IFNβ
R13349 T20233 T20227 conj kinases,IFNβ
R13350 T20234 T20233 punct (,kinases
R13351 T20235 T20233 appos RIP1,kinases
R13352 T20236 T20233 punct ",",kinases
R13353 T20237 T20233 conj IRAK1,kinases
R13354 T20238 T20237 punct ",",IRAK1
R13355 T20239 T20237 conj IRAK4,IRAK1
R13356 T20240 T20237 punct ),IRAK1
R13357 T20241 T20237 punct ",",IRAK1
R13358 T20242 T20237 cc and,IRAK1
R13359 T20243 T20244 compound ubiquitin,ligases
R13360 T20244 T20237 conj ligases,IRAK1
R13361 T20245 T20244 punct (,ligases
R13362 T20246 T20244 appos TRAF2,ligases
R13363 T20247 T20246 punct ",",TRAF2
R13364 T20248 T20246 conj TRAF6,TRAF2
R13365 T20249 T20244 punct ",",ligases
R13366 T20250 T20244 conj cIAP1,ligases
R13367 T20251 T20250 punct ",",cIAP1
R13368 T20252 T20250 conj cIAP2,cIAP1
R13369 T20253 T20227 punct ),IFNβ
R13370 T20254 T20204 prep to,recruitment
R13371 T20255 T20256 det the,receptor
R13372 T20256 T20254 pobj receptor,to
R13373 T20257 T20202 punct .,trigger
R13374 T20258 T20259 amod K63-linked,polyubiquitination
R13375 T20259 T20268 nsubjpass polyubiquitination,recognised
R13376 T20260 T20259 prep of,polyubiquitination
R13377 T20261 T20260 pobj TRAFs,of
R13378 T20262 T20261 punct ",",TRAFs
R13379 T20263 T20261 conj RIP1,TRAFs
R13380 T20264 T20263 cc and,RIP1
R13381 T20265 T20263 conj IRAK1,RIP1
R13382 T20266 T20268 punct ",",recognised
R13383 T20267 T20268 auxpass is,recognised
R13384 T20268 T20268 ROOT recognised,recognised
R13385 T20269 T20268 agent by,recognised
R13386 T20270 T20269 pobj NEMO,by
R13387 T20271 T20270 cc and,NEMO
R13388 T20272 T20270 conj TAB,NEMO
R13389 T20273 T20268 advcl proteins,recognised
R13390 T20274 T20268 punct ",",recognised
R13391 T20275 T20268 advcl resulting,recognised
R13392 T20276 T20275 prep in,resulting
R13393 T20277 T20278 det the,recruitment
R13394 T20278 T20276 pobj recruitment,in
R13395 T20279 T20278 cc and,recruitment
R13396 T20280 T20278 conj activation,recruitment
R13397 T20281 T20278 prep of,recruitment
R13398 T20282 T20283 advmod respectively,IKK2
R13399 T20283 T20275 npadvmod IKK2,resulting
R134 T148 T152 amod many,diseases
R13400 T20284 T20283 cc and,IKK2
R13401 T20285 T20283 conj TAK1,IKK2
R13402 T20286 T20268 punct .,recognised
R13403 T20287 T20289 nummod TAK1,phosphorylates
R13404 T20288 T20289 advmod then,phosphorylates
R13405 T20289 T20289 ROOT phosphorylates,phosphorylates
R13406 T20290 T20289 cc and,phosphorylates
R13407 T20291 T20289 conj activates,phosphorylates
R13408 T20292 T20291 dobj IKK2,activates
R13409 T20293 T20292 punct ",",IKK2
R13410 T20294 T20300 dep which,triggering
R13411 T20295 T20294 prep in,which
R13412 T20296 T20295 pobj turn,in
R13413 T20297 T20298 compound phosphorylates,IκBα
R13414 T20298 T20295 pobj IκBα,in
R13415 T20299 T20300 punct ",",triggering
R13416 T20300 T20291 advcl triggering,activates
R13417 T20301 T20303 poss its,ubiquitination
R13418 T20302 T20303 compound K48-linked,ubiquitination
R13419 T20303 T20300 dobj ubiquitination,triggering
R13420 T20304 T20303 cc and,ubiquitination
R13421 T20305 T20306 amod proteasomal,degradation
R13422 T20306 T20303 conj degradation,ubiquitination
R13423 T20307 T20289 punct .,phosphorylates
R13424 T20308 T20309 nsubj This,allows
R13425 T20309 T20309 ROOT allows,allows
R13426 T20310 T20309 dobj NF-κB,allows
R13427 T20311 T20313 punct (,shown
R13428 T20312 T20313 advmod here,shown
R13429 T20313 T20310 parataxis shown,NF-κB
R13430 T20314 T20313 prep as,shown
R13431 T20315 T20316 det a,heterodimer
R13432 T20316 T20314 pobj heterodimer,as
R13433 T20317 T20316 prep of,heterodimer
R13434 T20318 T20317 pobj p65,of
R13435 T20319 T20318 cc and,p65
R13436 T20320 T20318 conj p50,p65
R13437 T20321 T20313 punct ),shown
R13438 T20322 T20310 advmod to,NF-κB
R13439 T20323 T20322 pobj translocate,to
R13440 T20324 T20323 prep to,translocate
R13441 T20325 T20326 det the,nucleus
R13442 T20326 T20324 pobj nucleus,to
R13443 T20327 T20323 cc and,translocate
R13444 T20328 T20323 conj promote,translocate
R13445 T20329 T20330 compound target,gene
R13446 T20330 T20331 compound gene,expression
R13447 T20331 T20328 dobj expression,promote
R13448 T20332 T20309 punct .,allows
R13449 T20333 T20344 dep TRAF1,regulate
R13450 T20334 T20333 punct ",",TRAF1
R13451 T20335 T20336 nsubj which,has
R13452 T20336 T20333 relcl has,TRAF1
R13453 T20337 T20340 det no,activity
R13454 T20338 T20340 compound ubiquitin,activity
R13455 T20339 T20340 compound ligase,activity
R13456 T20340 T20336 dobj activity,has
R13457 T20341 T20344 punct ",",regulate
R13458 T20342 T20344 aux can,regulate
R13459 T20343 T20344 advmod negatively,regulate
R13460 T20344 T20344 ROOT regulate,regulate
R13461 T20345 T20346 amod NF-κB,activation
R13462 T20346 T20344 dobj activation,regulate
R13463 T20347 T20344 punct ",",regulate
R13464 T20348 T20349 advmod most,probably
R13465 T20349 T20350 advmod probably,by
R13466 T20350 T20344 prep by,regulate
R13467 T20351 T20350 pcomp competing,by
R13468 T20352 T20351 prep with,competing
R13469 T20353 T20354 amod other,TRAFs
R13470 T20354 T20352 pobj TRAFs,with
R13471 T20355 T20344 punct .,regulate
R13472 T20356 T20360 nsubj A20,deubiquitinating
R13473 T20357 T20356 cc and,A20
R13474 T20358 T20356 conj CYLD,A20
R13475 T20359 T20360 aux are,deubiquitinating
R13476 T20360 T20360 ROOT deubiquitinating,deubiquitinating
R13477 T20361 T20360 dobj enzymes,deubiquitinating
R13478 T20362 T20363 nsubj that,control
R13479 T20363 T20361 relcl control,enzymes
R13480 T20364 T20365 amod NF-κB,activation
R13481 T20365 T20363 dobj activation,control
R13482 T20366 T20363 prep by,control
R13483 T20367 T20366 pcomp targeting,by
R13484 T20368 T20370 amod specific,proteins
R13485 T20369 T20370 amod signalling,proteins
R13486 T20370 T20367 dobj proteins,targeting
R13487 T20371 T20370 prep including,proteins
R13488 T20372 T20371 pobj RIP1,including
R13489 T20373 T20372 cc and,RIP1
R13490 T20374 T20372 conj TRAF6,RIP1
R13491 T20375 T20370 punct ",",proteins
R13492 T20376 T20380 prep to,recruited
R13493 T20377 T20376 pobj which,to
R13494 T20378 T20380 nsubjpass they,recruited
R13495 T20379 T20380 auxpass are,recruited
R13496 T20380 T20367 ccomp recruited,targeting
R13497 T20381 T20380 advcl using,recruited
R13498 T20382 T20385 amod specific,proteins
R13499 T20383 T20385 amod ubiquitin-binding,proteins
R135 T149 T152 amod autoimmune,diseases
R13500 T20384 T20385 compound adaptor,proteins
R13501 T20385 T20381 dobj proteins,using
R13502 T20386 T20387 amod such,as
R13503 T20387 T20385 prep as,proteins
R13504 T20388 T20387 pobj ABIN-1,as
R13505 T20389 T20388 cc and,ABIN-1
R13506 T20390 T20388 conj p62,ABIN-1
R13507 T20391 T20360 punct .,deubiquitinating
R13508 T20392 T20394 nsubjpass miR-146,thought
R13509 T20393 T20394 auxpass is,thought
R13510 T20394 T20394 ROOT thought,thought
R13511 T20395 T20397 aux to,regulate
R13512 T20396 T20397 advmod negatively,regulate
R13513 T20397 T20394 xcomp regulate,thought
R13514 T20398 T20397 dobj TLR,regulate
R13515 T20399 T20397 oprd signalling,regulate
R13516 T20400 T20397 prep by,regulate
R13517 T20401 T20400 pcomp inhibiting,by
R13518 T20402 T20401 dobj expression,inhibiting
R13519 T20403 T20402 prep of,expression
R13520 T20404 T20403 pobj IRAK1,of
R13521 T20405 T20404 cc and,IRAK1
R13522 T20406 T20404 conj TRAF6,IRAK1
R13523 T20407 T20394 punct .,thought
R13524 T20408 T20415 advmod Finally,inhibited
R13525 T20409 T20415 punct ",",inhibited
R13526 T20410 T20411 compound TLR,signalling
R13527 T20411 T20415 nsubjpass signalling,inhibited
R13528 T20412 T20415 aux can,inhibited
R13529 T20413 T20415 advmod also,inhibited
R13530 T20414 T20415 auxpass be,inhibited
R13531 T20415 T20415 ROOT inhibited,inhibited
R13532 T20416 T20415 agent by,inhibited
R13533 T20417 T20419 det the,protein
R13534 T20418 T20419 compound transmembrane,protein
R13535 T20419 T20416 pobj protein,by
R13536 T20420 T20419 appos SIGIRR,protein
R13537 T20421 T20419 punct ",",protein
R13538 T20422 T20425 nsubjpass which,proposed
R13539 T20423 T20425 aux has,proposed
R13540 T20424 T20425 auxpass been,proposed
R13541 T20425 T20419 relcl proposed,protein
R13542 T20426 T20427 aux to,compete
R13543 T20427 T20425 xcomp compete,proposed
R13544 T20428 T20427 prep with,compete
R13545 T20429 T20428 pobj TLR4,with
R13546 T20430 T20429 prep for,TLR4
R13547 T20431 T20430 amod binding,for
R13548 T20432 T20431 prep to,binding
R13549 T20433 T20432 pobj IRAK1,to
R13550 T20434 T20433 cc and,IRAK1
R13551 T20435 T20433 conj TRAF6,IRAK1
R13552 T20436 T20415 punct .,inhibited
R13553 T20437 T20438 det The,expression
R13554 T20438 T20446 nsubj expression,is
R13555 T20439 T20438 prep of,expression
R13556 T20440 T20439 pobj many,of
R13557 T20441 T20440 prep of,many
R13558 T20442 T20445 det these,molecules
R13559 T20443 T20445 amod negative,molecules
R13560 T20444 T20445 amod regulatory,molecules
R13561 T20445 T20441 pobj molecules,of
R13562 T20446 T20446 ROOT is,is
R13563 T20447 T20448 advmod NF-κB,dependent
R13564 T20448 T20446 acomp dependent,is
R13565 T20449 T20446 punct ",",is
R13566 T20450 T20446 advcl implicating,is
R13567 T20451 T20450 dobj them,implicating
R13568 T20452 T20450 prep in,implicating
R13569 T20453 T20456 det the,regulation
R13570 T20454 T20456 amod negative,regulation
R13571 T20455 T20456 compound feedback,regulation
R13572 T20456 T20452 pobj regulation,in
R13573 T20457 T20456 prep of,regulation
R13574 T20458 T20459 amod NF-κB,activation
R13575 T20459 T20457 pobj activation,of
R13576 T20460 T20446 punct .,is
R13577 T20461 T20461 ROOT ABIN,ABIN
R13578 T20462 T20464 punct ",",inhibitor
R13579 T20463 T20464 amod A20-binding,inhibitor
R13580 T20464 T20461 appos inhibitor,ABIN
R13581 T20465 T20464 prep of,inhibitor
R13582 T20466 T20465 pobj NF-κB,of
R13583 T20467 T20461 punct ;,ABIN
R13584 T20468 T20461 conj cIAP,ABIN
R13585 T20469 T20468 punct ",",cIAP
R13586 T20470 T20471 amod cellular,inhibitor
R13587 T20471 T20468 appos inhibitor,cIAP
R13588 T20472 T20471 prep of,inhibitor
R13589 T20473 T20472 pobj apoptosis,of
R13590 T20474 T20468 punct ;,cIAP
R13591 T20475 T20468 conj CYLD,cIAP
R13592 T20476 T20475 punct ",",CYLD
R13593 T20477 T20475 appos cylindromatosis,CYLD
R13594 T20478 T20475 punct ;,CYLD
R13595 T20479 T20475 conj IKK,CYLD
R13596 T20480 T20479 punct ",",IKK
R13597 T20481 T20482 compound IκB,kinase
R13598 T20482 T20479 appos kinase,IKK
R13599 T20483 T20479 punct ;,IKK
R136 T150 T149 cc and,autoimmune
R13600 T20484 T20479 conj IκB,IKK
R13601 T20485 T20484 punct ",",IκB
R13602 T20486 T20484 appos inhibitor,IκB
R13603 T20487 T20486 prep of,inhibitor
R13604 T20488 T20487 pobj NF-κB,of
R13605 T20489 T20484 punct ;,IκB
R13606 T20490 T20484 conj IRAK,IκB
R13607 T20491 T20490 punct ",",IRAK
R13608 T20492 T20493 amod IL-1R-associated,kinase
R13609 T20493 T20490 appos kinase,IRAK
R13610 T20494 T20490 punct ;,IRAK
R13611 T20495 T20490 conj MyD88,IRAK
R13612 T20496 T20495 punct ",",MyD88
R13613 T20497 T20498 amod myeloid,differentiation
R13614 T20498 T20501 nmod differentiation,gene
R13615 T20499 T20501 amod primary,gene
R13616 T20500 T20501 compound response,gene
R13617 T20501 T20495 appos gene,MyD88
R13618 T20502 T20501 nummod 88,gene
R13619 T20503 T20495 punct ;,MyD88
R13620 T20504 T20495 conj NEMO,MyD88
R13621 T20505 T20504 punct ",",NEMO
R13622 T20506 T20508 nmod NF-κB,modulator
R13623 T20507 T20508 amod essential,modulator
R13624 T20508 T20504 appos modulator,NEMO
R13625 T20509 T20504 punct ;,NEMO
R13626 T20510 T20504 conj NF,NEMO
R13627 T20511 T20510 punct ",",NF
R13628 T20512 T20513 amod nuclear,factor
R13629 T20513 T20510 appos factor,NF
R13630 T20514 T20510 punct ;,NF
R13631 T20515 T20510 conj RANK,NF
R13632 T20516 T20515 punct ",",RANK
R13633 T20517 T20518 compound receptor,activator
R13634 T20518 T20515 appos activator,RANK
R13635 T20519 T20518 prep of,activator
R13636 T20520 T20519 pobj NF-κB,of
R13637 T20521 T20461 punct ;,ABIN
R13638 T20522 T20461 conj RIP1,ABIN
R13639 T20523 T20522 punct ",",RIP1
R13640 T20524 T20526 compound receptor,protein
R13641 T20525 T20526 compound interacting,protein
R13642 T20526 T20461 appos protein,ABIN
R13643 T20527 T20526 nummod 1,protein
R13644 T20528 T20461 punct ;,ABIN
R13645 T20529 T20461 conj SIGIRR,ABIN
R13646 T20530 T20529 punct ",",SIGIRR
R13647 T20531 T20532 amod single-immunoglobulinIL-1,receptor-related
R13648 T20532 T20529 amod receptor-related,SIGIRR
R13649 T20533 T20529 punct ;,SIGIRR
R13650 T20534 T20529 conj TIR,SIGIRR
R13651 T20535 T20534 punct ",",TIR
R13652 T20536 T20537 compound Toll-like,receptor/IL
R13653 T20537 T20534 conj receptor/IL,TIR
R13654 T20538 T20539 nummod -1,R
R13655 T20539 T20556 ccomp R,factor
R13656 T20540 T20539 punct ;,R
R13657 T20541 T20544 npadvmod TRAF,receptor-associated
R13658 T20542 T20544 punct ",",receptor-associated
R13659 T20543 T20544 nsubj TNF,receptor-associated
R13660 T20544 T20556 ccomp receptor-associated,factor
R13661 T20545 T20544 dobj factor,receptor-associated
R13662 T20546 T20556 punct ;,factor
R13663 T20547 T20556 poss TLR,factor
R13664 T20548 T20550 punct ",",receptor
R13665 T20549 T20550 amod Toll-like,receptor
R13666 T20550 T20547 appos receptor,TLR
R13667 T20551 T20547 punct ;,TLR
R13668 T20552 T20547 conj TNF,TLR
R13669 T20553 T20552 punct ",",TNF
R13670 T20554 T20556 compound tumour,factor
R13671 T20555 T20556 compound necrosis,factor
R13672 T20556 T20556 ROOT factor,factor
R13673 T20557 T20556 punct .,factor
R137 T151 T149 conj inflammatory,autoimmune
R138 T152 T147 pobj diseases,with
R139 T153 T152 punct ",",diseases
R140 T154 T152 prep including,diseases
R141 T155 T156 amod rheumatoid,arthritis
R142 T156 T154 pobj arthritis,including
R14226 T21854 T21855 compound Noncanonical,NF-κB
R14227 T21855 T21855 ROOT NF-κB,NF-κB
R14228 T21856 T21855 acl signalling,NF-κB
R14229 T21857 T21856 punct .,signalling
R14230 T21858 T21858 ROOT CD40,CD40
R14231 T21859 T21858 cc and,CD40
R14232 T21860 T21862 nsubj RANK,activate
R14233 T21861 T21862 aux can,activate
R14234 T21862 T21858 conj activate,CD40
R14235 T21863 T21866 det the,pathway
R14236 T21864 T21866 amod noncanonical,pathway
R14237 T21865 T21866 compound NF-κB,pathway
R14238 T21866 T21862 dobj pathway,activate
R14239 T21867 T21868 nsubj that,is
R14240 T21868 T21866 relcl is,pathway
R14241 T21869 T21868 acomp dependent,is
R14242 T21870 T21869 prep on,dependent
R14243 T21871 T21872 nsubj NF-κB,inducing
R14244 T21872 T21870 pcomp inducing,on
R14245 T21873 T21878 nmod kinase,levels
R14246 T21874 T21878 punct (,levels
R14247 T21875 T21878 compound NIK,levels
R14248 T21876 T21877 punct ),expression
R14249 T21877 T21878 compound expression,levels
R14250 T21878 T21872 dobj levels,inducing
R14251 T21879 T21862 punct .,activate
R14252 T21880 T21884 prep In,forms
R14253 T21881 T21882 amod unstimulated,cells
R14254 T21882 T21880 pobj cells,In
R14255 T21883 T21884 nsubj NIK,forms
R14256 T21884 T21884 ROOT forms,forms
R14257 T21885 T21887 det a,complex
R14258 T21886 T21887 amod cytosolic,complex
R14259 T21887 T21884 dobj complex,forms
R14260 T21888 T21887 prep with,complex
R14261 T21889 T21890 det the,ubiquitin
R14262 T21890 T21891 nsubj ubiquitin,ligases
R14263 T21891 T21884 conj ligases,forms
R14264 T21892 T21891 dobj TRAF2,ligases
R14265 T21893 T21892 punct ",",TRAF2
R14266 T21894 T21892 conj TRAF3,TRAF2
R14267 T21895 T21894 cc and,TRAF3
R14268 T21896 T21894 conj cIAP1/2,TRAF3
R14269 T21897 T21896 punct ",",cIAP1/2
R14270 T21898 T21899 nsubj which,facilitates
R14271 T21899 T21896 relcl facilitates,cIAP1/2
R14272 T21900 T21902 det the,polyubiquitination
R14273 T21901 T21902 amod K48-linked,polyubiquitination
R14274 T21902 T21899 dobj polyubiquitination,facilitates
R14275 T21903 T21902 cc and,polyubiquitination
R14276 T21904 T21905 amod proteasomal,degradation
R14277 T21905 T21902 conj degradation,polyubiquitination
R14278 T21906 T21905 prep of,degradation
R14279 T21907 T21906 pobj NIK,of
R14280 T21908 T21891 punct ",",ligases
R14281 T21909 T21891 advcl keeping,ligases
R14282 T21910 T21911 compound NIK,levels
R14283 T21911 T21909 dobj levels,keeping
R14284 T21912 T21909 oprd low,keeping
R14285 T21913 T21891 punct .,ligases
R14286 T21914 T21916 mark Upon,binding
R14287 T21915 T21916 advmod ligand,binding
R14288 T21916 T21920 advcl binding,recruited
R14289 T21917 T21920 punct ",",recruited
R14290 T21918 T21920 nsubjpass TRAF3,recruited
R14291 T21919 T21920 auxpass is,recruited
R14292 T21920 T21920 ROOT recruited,recruited
R14293 T21921 T21920 prep to,recruited
R14294 T21922 T21923 det the,receptor
R14295 T21923 T21921 pobj receptor,to
R14296 T21924 T21923 punct ",",receptor
R14297 T21925 T21927 advmod where,directs
R14298 T21926 T21927 nummod TRAF2,directs
R14299 T21927 T21923 relcl directs,receptor
R143 T157 T128 punct .,plays
R14300 T21928 T21930 amod nondegradative,polyubiquitination
R14301 T21929 T21930 amod K63-linked,polyubiquitination
R14302 T21930 T21927 dobj polyubiquitination,directs
R14303 T21931 T21930 prep of,polyubiquitination
R14304 T21932 T21931 pobj cIAP1/2,of
R14305 T21933 T21927 punct ",",directs
R14306 T21934 T21920 advcl resulting,recruited
R14307 T21935 T21934 prep in,resulting
R14308 T21936 T21937 poss their,activation
R14309 T21937 T21935 pobj activation,in
R14310 T21938 T21920 punct .,recruited
R14311 T21939 T21941 advmod Subsequently,directs
R14312 T21940 T21941 nsubj cIAP1/2,directs
R14313 T21941 T21941 ROOT directs,directs
R14314 T21942 T21944 poss its,polyubiquitination
R14315 T21943 T21944 amod K48-linked,polyubiquitination
R14316 T21944 T21941 dobj polyubiquitination,directs
R14317 T21945 T21944 prep to,polyubiquitination
R14318 T21946 T21945 pobj TRAF3,to
R14319 T21947 T21944 punct ",",polyubiquitination
R14320 T21948 T21949 advmod rather,than
R14321 T21949 T21944 cc than,polyubiquitination
R14322 T21950 T21949 pobj NIK,than
R14323 T21951 T21941 punct .,directs
R14324 T21952 T21957 prep As,is
R14325 T21953 T21954 det a,result
R14326 T21954 T21952 pobj result,As
R14327 T21955 T21957 punct ",",is
R14328 T21956 T21957 nsubj TRAF3,is
R14329 T21957 T21957 ROOT is,is
R14330 T21958 T21957 acomp degraded,is
R14331 T21959 T21957 cc and,is
R14332 T21960 T21961 nsubj NIK,is
R14333 T21961 T21957 conj is,is
R14334 T21962 T21961 acomp stabilised,is
R14335 T21963 T21961 punct ",",is
R14336 T21964 T21961 advcl resulting,is
R14337 T21965 T21964 prep in,resulting
R14338 T21966 T21968 amod increased,levels
R14339 T21967 T21968 compound NIK,levels
R14340 T21968 T21965 pobj levels,in
R14341 T21969 T21968 prep in,levels
R14342 T21970 T21971 det the,cell
R14343 T21971 T21969 pobj cell,in
R14344 T21972 T21961 punct .,is
R14345 T21973 T21975 nsubj NIK,phosphorylates
R14346 T21974 T21975 advmod then,phosphorylates
R14347 T21975 T21975 ROOT phosphorylates,phosphorylates
R14348 T21976 T21975 cc and,phosphorylates
R14349 T21977 T21975 conj activates,phosphorylates
R14350 T21978 T21977 dobj IKK1,activates
R14351 T21979 T21978 punct ",",IKK1
R14352 T21980 T21981 nsubj which,mediates
R14353 T21981 T21978 relcl mediates,IKK1
R14354 T21982 T21984 nmod NF-κB,phosphorylation
R14355 T21983 T21984 nummod p100,phosphorylation
R14356 T21984 T21981 dobj phosphorylation,mediates
R14357 T21985 T21975 punct .,phosphorylates
R14358 T21986 T21988 nsubjpass This,followed
R14359 T21987 T21988 auxpass is,followed
R14360 T21988 T21988 ROOT followed,followed
R14361 T21989 T21988 agent by,followed
R14362 T21990 T21991 amod K48-linked,polyubiquitination
R14363 T21991 T21989 pobj polyubiquitination,by
R14364 T21992 T21991 cc and,polyubiquitination
R14365 T21993 T21995 amod partial,degradation
R14366 T21994 T21995 amod proteasomal,degradation
R14367 T21995 T21991 conj degradation,polyubiquitination
R14368 T21996 T21995 prep of,degradation
R14369 T21997 T21996 pobj p100,of
R14370 T21998 T21995 prep to,degradation
R14371 T21999 T21998 pobj p52,to
R14372 T22000 T21999 punct ",",p52
R14373 T22001 T22002 nsubj which,forms
R14374 T22002 T21999 relcl forms,p52
R14375 T22003 T22004 det a,heterodimer
R14376 T22004 T22002 dobj heterodimer,forms
R14377 T22005 T22004 prep with,heterodimer
R14378 T22006 T22005 pobj RelB,with
R14379 T22007 T22008 aux to,activate
R14380 T22008 T22002 advcl activate,forms
R14381 T22009 T22008 dobj transcription,activate
R14382 T22010 T21988 punct .,followed
R14383 T22011 T22019 advmod Next,identified
R14384 T22012 T22011 prep to,Next
R14385 T22013 T22012 pobj TRAF3,to
R14386 T22014 T22019 punct ",",identified
R14387 T22015 T22019 nsubjpass TRAF1,identified
R14388 T22016 T22019 aux has,identified
R14389 T22017 T22019 advmod also,identified
R14390 T22018 T22019 auxpass been,identified
R14391 T22019 T22019 ROOT identified,identified
R14392 T22020 T22019 prep as,identified
R14393 T22021 T22023 det a,regulator
R14394 T22022 T22023 amod negative,regulator
R14395 T22023 T22020 pobj regulator,as
R14396 T22024 T22023 prep of,regulator
R14397 T22025 T22026 det this,pathway
R14398 T22026 T22024 pobj pathway,of
R14399 T22027 T22023 punct ",",regulator
R144 T158 T159 nsubj Cells,employ
R14400 T22028 T22029 advmod most,probably
R14401 T22029 T22030 advmod probably,by
R14402 T22030 T22019 agent by,identified
R14403 T22031 T22030 pcomp competing,by
R14404 T22032 T22031 prep with,competing
R14405 T22033 T22036 amod other,factors
R14406 T22034 T22036 nmod TNF,factors
R14407 T22035 T22036 amod receptor-associated,factors
R14408 T22036 T22032 pobj factors,with
R14409 T22037 T22019 punct .,identified
R14410 T22038 T22038 ROOT cIAP,cIAP
R14411 T22039 T22038 punct ",",cIAP
R14412 T22040 T22041 amod cellular,inhibitor
R14413 T22041 T22038 appos inhibitor,cIAP
R14414 T22042 T22041 prep of,inhibitor
R14415 T22043 T22042 pobj apoptosis,of
R14416 T22044 T22038 punct ;,cIAP
R14417 T22045 T22038 conj IKK,cIAP
R14418 T22046 T22045 punct ",",IKK
R14419 T22047 T22048 compound IκB,kinase
R14420 T22048 T22045 appos kinase,IKK
R14421 T22049 T22045 punct ;,IKK
R14422 T22050 T22045 conj NF,IKK
R14423 T22051 T22050 punct ",",NF
R14424 T22052 T22053 amod nuclear,factor
R14425 T22053 T22050 appos factor,NF
R14426 T22054 T22050 punct ;,NF
R14427 T22055 T22050 conj RANK,NF
R14428 T22056 T22055 punct ",",RANK
R14429 T22057 T22058 compound receptor,activator
R14430 T22058 T22038 appos activator,cIAP
R14431 T22059 T22058 prep of,activator
R14432 T22060 T22059 pobj NF-κB,of
R14433 T22061 T22038 punct ;,cIAP
R14434 T22062 T22038 conj TRAF,cIAP
R14435 T22063 T22066 punct ",",factor
R14436 T22064 T22066 nmod TNF,factor
R14437 T22065 T22066 amod receptor-associated,factor
R14438 T22066 T22038 appos factor,cIAP
R14439 T22067 T22038 punct ;,cIAP
R14440 T22068 T22038 conj TNF,cIAP
R14441 T22069 T22068 punct ",",TNF
R14442 T22070 T22072 compound tumour,factor
R14443 T22071 T22072 compound necrosis,factor
R14444 T22072 T22038 appos factor,cIAP
R14445 T22073 T22038 punct .,cIAP
R145 T159 T159 ROOT employ,employ
R146 T160 T163 det a,system
R147 T161 T163 amod multilayered,system
R148 T162 T163 compound control,system
R149 T163 T159 dobj system,employ
R150 T164 T165 aux to,keep
R151 T165 T163 relcl keep,system
R152 T166 T167 amod NF-κB,signalling
R153 T167 T165 dobj signalling,keep
R154 T168 T165 prep in,keep
R155 T169 T168 pobj check,in
R156 T170 T165 punct ",",keep
R157 T171 T165 prep including,keep
R158 T172 T173 det a,repertoire
R159 T173 T171 pobj repertoire,including
R160 T174 T173 prep of,repertoire
R161 T175 T177 amod negative,regulators
R162 T176 T177 compound feedback,regulators
R163 T177 T174 pobj regulators,of
R164 T178 T173 acl ensuring,repertoire
R165 T179 T178 dobj termination,ensuring
R166 T180 T179 prep of,termination
R167 T181 T182 amod NF-κB,responses
R168 T182 T180 pobj responses,of
R169 T183 T159 punct .,employ
R170 T184 T187 advmod Here,review
R171 T185 T187 nsubj we,review
R172 T186 T187 aux will,review
R173 T187 T187 ROOT review,review
R174 T188 T191 amod various,mechanisms
R175 T189 T191 amod negative,mechanisms
R176 T190 T191 amod regulatory,mechanisms
R177 T191 T187 dobj mechanisms,review
R178 T192 T194 nsubj that,evolved
R179 T193 T194 aux have,evolved
R180 T194 T191 relcl evolved,mechanisms
R181 T195 T196 aux to,control
R182 T196 T194 xcomp control,evolved
R183 T197 T198 compound NF-κB,signalling
R184 T198 T196 dobj signalling,control
R185 T199 T194 cc and,evolved
R186 T200 T203 nsubjpass which,implicated
R187 T201 T203 aux have,implicated
R188 T202 T203 auxpass been,implicated
R189 T203 T194 conj implicated,evolved
R190 T204 T203 prep in,implicated
R191 T205 T206 det the,pathogenesis
R192 T206 T204 pobj pathogenesis,in
R193 T207 T206 prep of,pathogenesis
R194 T208 T209 amod rheumatoid,arthritis
R195 T209 T207 pobj arthritis,of
R196 T210 T187 punct .,review
R1987 T2608 T2610 mark Since,is
R1988 T2609 T2610 nsubj NF-κB,is
R1989 T2610 T2622 advcl is,deals
R1990 T2611 T2610 acomp central,is
R1991 T2612 T2611 prep to,central
R1992 T2613 T2614 det the,process
R1993 T2614 T2612 pobj process,to
R1994 T2615 T2614 prep of,process
R1995 T2616 T2615 pobj inflammation,of
R1996 T2617 T2614 prep in,process
R1997 T2618 T2617 pobj RA,in
R1998 T2619 T2622 punct ",",deals
R1999 T2620 T2622 amod much,deals
R2000 T2621 T2622 compound research,deals
R2001 T2622 T2622 ROOT deals,deals
R2002 T2623 T2622 prep with,deals
R2003 T2624 T2625 det the,identification
R2004 T2625 T2623 pobj identification,with
R2005 T2626 T2625 prep of,identification
R2006 T2627 T2628 det the,molecular
R2007 T2628 T2626 pobj molecular,of
R2008 T2629 T2622 conj triggers,deals
R2009 T2630 T2631 nsubj that,activate
R2010 T2631 T2629 ccomp activate,triggers
R2011 T2632 T2631 dobj NF-κB,activate
R2012 T2633 T2631 prep in,activate
R2013 T2634 T2633 pobj RA,in
R2014 T2635 T2629 punct .,triggers
R2015 T2636 T2639 nsubjpass It,accepted
R2016 T2637 T2639 auxpass is,accepted
R2017 T2638 T2639 advmod well,accepted
R2018 T2639 T2639 ROOT accepted,accepted
R2019 T2640 T2648 mark that,play
R2020 T2641 T2642 amod proinflammatory,cytokines
R2021 T2642 T2648 nsubj cytokines,play
R2022 T2643 T2644 amod such,as
R2023 T2644 T2642 prep as,cytokines
R2024 T2645 T2644 pobj TNF,as
R2025 T2646 T2645 cc and,TNF
R2026 T2647 T2645 conj IL-1,TNF
R2027 T2648 T2639 ccomp play,accepted
R2028 T2649 T2651 det an,role
R2029 T2650 T2651 amod important,role
R2030 T2651 T2648 dobj role,play
R2031 T2652 T2648 punct ",",play
R2032 T2653 T2648 cc and,play
R2033 T2654 T2648 conj administration,play
R2034 T2655 T2654 prep of,administration
R2035 T2656 T2657 compound TNF,antagonists
R2036 T2657 T2655 pobj antagonists,of
R2037 T2658 T2639 conj is,accepted
R2038 T2659 T2661 det an,treatment
R2039 T2660 T2661 amod effective,treatment
R2040 T2661 T2658 attr treatment,is
R2041 T2662 T2661 prep for,treatment
R2042 T2663 T2664 amod severe,RA
R2043 T2664 T2662 pobj RA,for
R2044 T2665 T2666 punct (,reviewed
R2045 T2666 T2664 parataxis reviewed,RA
R2046 T2667 T2666 prep in,reviewed
R2047 T2668 T2667 pobj [,in
R2048 T2669 T2670 nummod 9,]
R2049 T2670 T2668 appos ],[
R2050 T2671 T2668 punct ),[
R2051 T2672 T2639 punct .,accepted
R2052 T2673 T2676 nsubj TNF,are
R2053 T2674 T2673 cc and,TNF
R2054 T2675 T2673 conj IL-1,TNF
R2055 T2676 T2676 ROOT are,are
R2056 T2677 T2676 dep both,are
R2057 T2678 T2679 advmod very,potent
R2058 T2679 T2680 amod potent,activators
R2059 T2680 T2676 attr activators,are
R2060 T2681 T2680 prep of,activators
R2061 T2682 T2681 pobj NF-κB,of
R2062 T2683 T2676 cc and,are
R2063 T2684 T2687 nsubjpass it,expected
R2064 T2685 T2687 aux can,expected
R2065 T2686 T2687 auxpass be,expected
R2066 T2687 T2676 conj expected,are
R2067 T2688 T2690 det that,activation
R2068 T2689 T2690 amod NF-κB,activation
R2069 T2690 T2694 nsubj activation,mediates
R2070 T2691 T2690 prep by,activation
R2071 T2692 T2693 det these,cytokines
R2072 T2693 T2691 pobj cytokines,by
R2073 T2694 T2676 conj mediates,are
R2074 T2695 T2694 dobj most,mediates
R2075 T2696 T2695 prep of,most
R2076 T2697 T2699 poss their,activities
R2077 T2698 T2699 amod pro-inflammatory,activities
R2078 T2699 T2696 pobj activities,of
R2079 T2700 T2699 prep in,activities
R2080 T2701 T2700 pobj RA,in
R2081 T2702 T2701 punct (,RA
R2082 T2703 T2694 advcl reviewed,mediates
R2083 T2704 T2703 prep in,reviewed
R2084 T2705 T2704 pobj [,in
R2085 T2706 T2707 nummod 3,]
R2086 T2707 T2705 appos ],[
R2087 T2708 T2705 punct ),[
R2088 T2709 T2694 punct .,mediates
R2089 T2710 T2711 amod NF-κB,activation
R2090 T2711 T2727 nsubj activation,is
R2091 T2712 T2711 prep by,activation
R2092 T2713 T2712 pobj receptor,by
R2093 T2714 T2711 conj activator,activation
R2094 T2715 T2711 prep of,activation
R2095 T2716 T2715 pobj NF-κB,of
R2096 T2717 T2716 punct (,NF-κB
R2097 T2718 T2716 appos RANK,NF-κB
R2098 T2719 T2716 punct ),NF-κB
R2099 T2720 T2716 punct ",",NF-κB
R2100 T2721 T2725 det a,member
R2101 T2722 T2725 compound TNF,member
R2102 T2723 T2725 compound receptor,member
R2103 T2724 T2725 compound family,member
R2104 T2725 T2716 appos member,NF-κB
R2105 T2726 T2727 punct ",",is
R2106 T2727 T2727 ROOT is,is
R2107 T2728 T2727 acomp important,is
R2108 T2729 T2728 prep for,important
R2109 T2730 T2729 pobj osteoclastogenesis,for
R2110 T2731 T2729 punct ",",for
R2111 T2732 T2728 cc and,important
R2112 T2733 T2728 conj defects,important
R2113 T2734 T2727 prep in,is
R2114 T2735 T2736 amod proper,RANK-NF-κB
R2115 T2736 T2734 pobj RANK-NF-κB,in
R2116 T2737 T2738 nsubj signalling,are
R2117 T2738 T2727 conj are,is
R2118 T2739 T2738 acomp likely,are
R2119 T2740 T2742 aux to,involved
R2120 T2741 T2742 auxpass be,involved
R2121 T2742 T2739 xcomp involved,likely
R2122 T2743 T2742 prep in,involved
R2123 T2744 T2745 compound RA,pathology
R2124 T2745 T2743 pobj pathology,in
R2125 T2746 T2745 cc and,pathology
R2126 T2747 T2748 amod other,diseases
R2127 T2748 T2745 conj diseases,pathology
R2128 T2749 T2748 acl associated,diseases
R2129 T2750 T2749 prep with,associated
R2130 T2751 T2752 compound bone,loss
R2131 T2752 T2753 compound loss,[
R2132 T2753 T2755 compound [,]
R2133 T2754 T2755 nummod 7,]
R2134 T2755 T2750 pobj ],with
R2135 T2756 T2738 punct .,are
R2136 T2757 T2758 nsubj CD40,is
R2137 T2758 T2758 ROOT is,is
R2138 T2759 T2763 det another,member
R2139 T2760 T2763 compound TNF,member
R2140 T2761 T2763 compound receptor,member
R2141 T2762 T2763 compound family,member
R2142 T2763 T2758 attr member,is
R2143 T2764 T2767 nsubjpass that,expressed
R2144 T2765 T2767 auxpass is,expressed
R2145 T2766 T2767 advmod functionally,expressed
R2146 T2767 T2763 relcl expressed,member
R2147 T2768 T2767 prep on,expressed
R2148 T2769 T2770 det a,variety
R2149 T2770 T2768 pobj variety,on
R2150 T2771 T2770 prep of,variety
R2151 T2772 T2773 compound cell,types
R2152 T2773 T2771 pobj types,of
R2153 T2774 T2770 punct ",",variety
R2154 T2775 T2770 prep including,variety
R2155 T2776 T2777 amod smooth,muscle
R2156 T2777 T2778 compound muscle,fibroblasts
R2157 T2778 T2775 pobj fibroblasts,including
R2158 T2779 T2778 prep from,fibroblasts
R2159 T2780 T2783 amod normal,patients
R2160 T2781 T2780 cc and,normal
R2161 T2782 T2783 compound RA,patients
R2162 T2783 T2779 pobj patients,from
R2163 T2784 T2778 cc and,fibroblasts
R2164 T2785 T2787 nmod RA,cells
R2165 T2786 T2787 amod synovial,cells
R2166 T2787 T2778 conj cells,fibroblasts
R2167 T2788 T2787 punct ",",cells
R2168 T2789 T2790 compound B,cells
R2169 T2790 T2787 conj cells,cells
R2170 T2791 T2790 punct ",",cells
R2171 T2792 T2790 conj macrophages,cells
R2172 T2793 T2792 punct ",",macrophages
R2173 T2794 T2792 cc and,macrophages
R2174 T2795 T2796 amod dendritic,cells
R2175 T2796 T2792 conj cells,macrophages
R2176 T2797 T2758 punct ",",is
R2177 T2798 T2758 cc and,is
R2178 T2799 T2801 aux can,upregulated
R2179 T2800 T2801 auxpass be,upregulated
R2180 T2801 T2758 conj upregulated,is
R2181 T2802 T2801 agent by,upregulated
R2182 T2803 T2804 amod proinflammatory,cytokines
R2183 T2804 T2802 pobj cytokines,by
R2184 T2805 T2804 prep including,cytokines
R2185 T2806 T2807 compound TNF,[
R2186 T2807 T2805 pobj [,including
R2187 T2808 T2809 nummod 10,]
R2188 T2809 T2807 appos ],[
R2189 T2810 T2758 punct .,is
R2190 T2811 T2834 advcl Binding,triggers
R2191 T2812 T2811 prep of,Binding
R2192 T2813 T2815 det the,ligand
R2193 T2814 T2815 compound CD40,ligand
R2194 T2815 T2812 pobj ligand,of
R2195 T2816 T2817 punct (,CD154
R2196 T2817 T2815 appos CD154,ligand
R2197 T2818 T2817 punct ),CD154
R2198 T2819 T2815 punct ",",ligand
R2199 T2820 T2823 nsubjpass which,expressed
R2200 T2821 T2823 auxpass is,expressed
R2201 T2822 T2823 advmod transiently,expressed
R2202 T2823 T2815 relcl expressed,ligand
R2203 T2824 T2823 prep on,expressed
R2204 T2825 T2826 det the,surface
R2205 T2826 T2824 pobj surface,on
R2206 T2827 T2826 prep of,surface
R2207 T2828 T2832 amod activated,cells
R2208 T2829 T2832 compound CD4,cells
R2209 T2830 T2832 nummod +,cells
R2210 T2831 T2832 compound T,cells
R2211 T2832 T2827 pobj cells,of
R2212 T2833 T2834 punct ",",triggers
R2213 T2834 T2834 ROOT triggers,triggers
R2214 T2835 T2836 compound NF-κB,activation
R2215 T2836 T2834 dobj activation,triggers
R2216 T2837 T2836 acl resulting,activation
R2217 T2838 T2837 prep in,resulting
R2218 T2839 T2840 compound fibroblast,proliferation
R2219 T2840 T2838 pobj proliferation,in
R2220 T2841 T2840 cc and,proliferation
R2221 T2842 T2840 conj secretion,proliferation
R2222 T2843 T2842 prep of,secretion
R2223 T2844 T2845 amod proinflammatory,cytokines
R2224 T2845 T2843 pobj cytokines,of
R2225 T2846 T2845 cc and,cytokines
R2226 T2847 T2845 conj chemokines,cytokines
R2227 T2848 T2845 punct ",",cytokines
R2228 T2849 T2850 nsubj which,contributes
R2229 T2850 T2840 relcl contributes,proliferation
R2230 T2851 T2850 prep to,contributes
R2231 T2852 T2853 amod joint,destruction
R2232 T2853 T2851 pobj destruction,to
R2233 T2854 T2834 punct .,triggers
R2234 T2855 T2864 advmod However,led
R2235 T2856 T2864 punct ",",led
R2236 T2857 T2864 nsubj studies,led
R2237 T2858 T2857 prep with,studies
R2238 T2859 T2863 amod antagonistic,antibodies
R2239 T2860 T2863 amod anti-CD40,antibodies
R2240 T2861 T2860 cc or,anti-CD40
R2241 T2862 T2860 conj anti-CD154,anti-CD40
R2242 T2863 T2858 pobj antibodies,with
R2243 T2923 T2918 pobj lymphocytes,of
R2244 T2864 T2864 ROOT led,led
R2245 T2924 T2925 punct ",",is
R2246 T2865 T2864 prep to,led
R2247 T2925 T2925 ROOT is,is
R2248 T2926 T2925 advmod also,is
R2249 T2866 T2867 det the,conclusion
R2250 T2927 T2925 acomp characteristic,is
R2251 T2928 T2927 prep for,characteristic
R2252 T2929 T2928 pobj RA,for
R2253 T2867 T2865 pobj conclusion,to
R2254 T2930 T2925 punct ",",is
R2255 T2931 T2925 cc and,is
R2256 T2932 T2937 nsubjpass antagonists,developed
R2257 T2868 T2872 mark that,be
R2258 T2933 T2932 prep of,antagonists
R2259 T2934 T2933 pobj BAFF,of
R2260 T2935 T2937 aux have,developed
R2261 T2869 T2870 compound CD40,signals
R2262 T2936 T2937 auxpass been,developed
R2263 T2937 T2925 conj developed,is
R2264 T2938 T2939 aux to,counter
R2265 T2870 T2872 nsubj signals,be
R2266 T2939 T2937 advcl counter,developed
R2267 T2940 T2941 compound RA,[
R2268 T2941 T2939 dobj [,counter
R2269 T2871 T2872 aux may,be
R2270 T2942 T2943 nummod 13,]
R2271 T2943 T2941 appos ],[
R2272 T2944 T2925 punct .,is
R2273 T2872 T2867 acl be,conclusion
R2274 T2945 T2953 advmod Finally,implicated
R2275 T2946 T2953 punct ",",implicated
R2276 T2947 T2950 amod lymphotoxin,signalling
R2277 T2948 T2949 compound β,receptor
R2278 T2949 T2950 compound receptor,signalling
R2279 T2873 T2872 acomp important,be
R2280 T2950 T2953 nsubjpass signalling,implicated
R2281 T2951 T2953 aux has,implicated
R2282 T2874 T2872 prep at,be
R2283 T2952 T2953 auxpass been,implicated
R2284 T2953 T2953 ROOT implicated,implicated
R2285 T2954 T2953 prep in,implicated
R2286 T2955 T2958 amod tertiary,formation
R2287 T2875 T2877 det the,stages
R2288 T2876 T2877 amod initial,stages
R2289 T2956 T2958 amod lymphoid,formation
R2290 T2877 T2874 pobj stages,at
R2291 T2957 T2958 compound organ,formation
R2292 T2958 T2954 pobj formation,in
R2293 T2959 T2958 prep at,formation
R2294 T2878 T2877 prep of,stages
R2295 T2960 T2959 pobj sites,at
R2296 T2961 T2960 prep of,sites
R2297 T2962 T2963 amod chronic,inflammation
R2298 T2879 T2880 compound arthritis,induction
R2299 T2963 T2961 pobj inflammation,of
R2300 T2964 T2960 prep including,sites
R2301 T2965 T2966 compound RA,[
R2302 T2880 T2878 pobj induction,of
R2303 T2966 T2964 pobj [,including
R2304 T2967 T2968 nummod 13,]
R2305 T2968 T2966 appos ],[
R2306 T2881 T2864 punct ",",led
R2307 T2969 T2953 punct .,implicated
R2308 T2970 T2971 amod Toll-like,receptors
R2309 T2882 T2864 cc but,led
R2310 T2971 T2977 nsubjpass receptors,implicated
R2311 T2972 T2971 punct (,receptors
R2312 T2973 T2971 appos TLRs,receptors
R2313 T2974 T2971 punct ),receptors
R2314 T2883 T2885 auxpass are,required
R2315 T2975 T2977 aux have,implicated
R2316 T2976 T2977 auxpass been,implicated
R2317 T2977 T2977 ROOT implicated,implicated
R2318 T2884 T2885 neg not,required
R2319 T2978 T2977 prep in,implicated
R2320 T2979 T2980 det a,variety
R2321 T2885 T2864 conj required,led
R2322 T2980 T2978 pobj variety,in
R2323 T2981 T2980 prep of,variety
R2324 T2982 T2983 amod autoimmune,diseases
R2325 T2983 T2981 pobj diseases,of
R2326 T2984 T2977 cc and,implicated
R2327 T2985 T2977 conj are,implicated
R2328 T2886 T2889 mark once,established
R2329 T2986 T2987 amod potential,candidates
R2330 T2987 T2985 attr candidates,are
R2331 T2988 T2987 prep for,candidates
R2332 T2989 T2988 pcomp inducing,for
R2333 T2887 T2889 nsubjpass disease,established
R2334 T2990 T2991 amod NF-κB-dependent,inflammation
R2335 T2991 T2989 dobj inflammation,inducing
R2336 T2888 T2889 auxpass is,established
R2337 T2992 T2991 prep in,inflammation
R2338 T2993 T2992 pobj RA,in
R2339 T2994 T2977 punct .,implicated
R2340 T2995 T3021 prep In,reported
R2341 T2889 T2885 advcl established,required
R2342 T2996 T2995 pobj addition,In
R2343 T2997 T2996 prep to,addition
R2344 T2998 T2999 amod microbial,ligands
R2345 T2890 T2889 cc and,established
R2346 T2999 T2997 pobj ligands,to
R2347 T3000 T2999 punct ",",ligands
R2348 T2891 T2889 conj pathogenic,established
R2349 T3001 T3003 det an,number
R2350 T3002 T3003 amod increasing,number
R2351 T3003 T2999 appos number,ligands
R2352 T2892 T2893 nsubj antibodies,are
R2353 T3004 T3003 prep of,number
R2354 T3005 T3006 amod endogenous,ligands
R2355 T3006 T3004 pobj ligands,of
R2356 T2893 T2864 conj are,led
R2357 T3007 T3006 punct -,ligands
R2358 T3008 T3009 det a,group
R2359 T3009 T3003 conj group,number
R2360 T2894 T2893 advmod already,are
R2361 T3010 T3009 prep of,group
R2362 T3011 T3010 pobj proteins,of
R2363 T3012 T3011 acl derived,proteins
R2364 T2895 T2893 acomp present,are
R2365 T3013 T3012 prep from,derived
R2366 T3014 T3015 compound host,tissues
R2367 T3015 T3013 pobj tissues,from
R2368 T2896 T2898 compound [,]
R2369 T3016 T3015 cc and,tissues
R2370 T3017 T3015 conj cells,tissues
R2371 T3018 T3021 punct -,reported
R2372 T2897 T2898 compound "11,12",]
R2373 T3019 T3021 aux have,reported
R2374 T2898 T2893 attr ],are
R2375 T2899 T2893 punct .,are
R2376 T3020 T3021 auxpass been,reported
R2377 T3021 T3021 ROOT reported,reported
R2378 T3022 T3021 prep as,reported
R2379 T3023 T3024 compound candidate,activators
R2380 T2900 T2901 amod Enhanced,expression
R2381 T3024 T3022 pobj activators,as
R2382 T3025 T3024 prep of,activators
R2383 T3026 T3025 pobj TLRs,of
R2384 T3027 T3024 acl inducing,activators
R2385 T2901 T2925 nsubj expression,is
R2386 T3028 T3030 amod so-called,inflammation
R2387 T2902 T2901 prep of,expression
R2388 T3029 T3030 amod sterile,inflammation
R2389 T3030 T3027 dobj inflammation,inducing
R2390 T3031 T3030 punct (,inflammation
R2391 T2903 T2907 det the,member
R2392 T3032 T3030 acl reviewed,inflammation
R2393 T2904 T2907 compound TNF,member
R2394 T3033 T3032 prep in,reviewed
R2395 T2905 T2907 compound receptor,member
R2396 T3034 T3033 pobj [,in
R2397 T3035 T3036 nummod "14,15",]
R2398 T2906 T2907 compound family,member
R2399 T3036 T3034 appos ],[
R2400 T2907 T2910 nmod member,factor
R2401 T3037 T3034 punct ),[
R2402 T2908 T2910 nmod B-cell,factor
R2403 T3038 T3021 punct .,reported
R2404 T3039 T3041 nsubjpass TLRs,expressed
R2405 T3040 T3041 auxpass are,expressed
R2406 T2909 T2910 amod activating,factor
R2407 T3041 T3041 ROOT expressed,expressed
R2408 T3042 T3041 prep in,expressed
R2409 T3043 T3045 compound RA,tissues
R2410 T2910 T2902 pobj factor,of
R2411 T3044 T3045 compound synovial,tissues
R2412 T3045 T3042 pobj tissues,in
R2413 T2911 T2912 punct (,BAFF
R2414 T3046 T3045 cc and,tissues
R2415 T3047 T3049 amod various,ligands
R2416 T3048 T3049 amod endogenous,ligands
R2417 T2912 T2910 appos BAFF,factor
R2418 T3049 T3045 conj ligands,tissues
R2419 T3050 T3041 conj are,expressed
R2420 T2913 T2910 punct ),factor
R2421 T3051 T3050 acomp present,are
R2422 T3052 T3050 prep within,are
R2423 T3053 T3055 det the,joints
R2424 T3054 T3055 amod inflamed,joints
R2425 T2914 T2901 punct ",",expression
R2426 T3055 T3052 pobj joints,within
R2427 T3056 T3055 prep of,joints
R2428 T3057 T3058 compound RA,patients
R2429 T3058 T3056 pobj patients,of
R2430 T3059 T3041 punct .,expressed
R2431 T3060 T3075 advmod Moreover,identify
R2432 T2915 T2901 acl allowing,expression
R2433 T3061 T3075 punct ",",identify
R2434 T3062 T3063 compound animal,models
R2435 T3063 T3075 nsubj models,identify
R2436 T2916 T2917 det the,survival
R2437 T3064 T3063 acl using,models
R2438 T3065 T3067 compound TLR,mice
R2439 T3066 T3067 compound knockout,mice
R2440 T2917 T2915 dobj survival,allowing
R2441 T3067 T3064 dobj mice,using
R2442 T3068 T3067 cc or,mice
R2443 T3069 T3067 conj strategies,mice
R2444 T2918 T2917 prep of,survival
R2445 T3070 T3071 aux to,block
R2446 T3071 T3064 xcomp block,using
R2447 T3072 T3071 dobj TLR,block
R2448 T3073 T3064 conj signalling,using
R2449 T2919 T2921 npadvmod autoantibody,producing
R2450 T3074 T3075 advmod clearly,identify
R2451 T3075 T3075 ROOT identify,identify
R2452 T3076 T3077 amod TLR-dependent,inflammation
R2453 T2920 T2921 punct -,producing
R2454 T3077 T3075 dobj inflammation,identify
R2455 T3078 T3075 prep as,identify
R2456 T3079 T3078 pcomp being,as
R2457 T2921 T2923 amod producing,lymphocytes
R2458 T3080 T3079 acomp important,being
R2459 T3081 T3079 prep in,being
R2460 T3082 T3083 det the,pathogenesis
R2461 T2922 T2923 compound B,lymphocytes
R2462 T3083 T3081 pobj pathogenesis,in
R2463 T3084 T3083 prep of,pathogenesis
R2464 T3085 T3086 det the,disease
R2465 T3117 T3093 punct ",",protein
R2466 T3086 T3084 pobj disease,of
R2467 T3087 T3075 punct .,identify
R2468 T3088 T3091 amod High,box
R2469 T3118 T3118 ROOT is,is
R2470 T3089 T3091 compound mobility,box
R2471 T3090 T3091 compound group,box
R2472 T3091 T3093 compound box,protein
R2473 T3092 T3093 compound chromosomal,protein
R2474 T3119 T3118 attr one,is
R2475 T3093 T3118 nsubj protein,is
R2476 T3094 T3093 nummod 1,protein
R2477 T3095 T3093 punct (,protein
R2478 T3096 T3093 appos HMGB1,protein
R2479 T3097 T3093 punct ),protein
R2480 T3098 T3093 punct ",",protein
R2481 T3120 T3119 prep of,one
R2482 T3099 T3103 det a,component
R2483 T3100 T3101 advmod highly,conserved
R2484 T3101 T3103 amod conserved,component
R2485 T3102 T3103 compound chromatin,component
R2486 T3121 T3126 det the,ligands
R2487 T3103 T3093 appos component,protein
R2488 T3104 T3108 nsubjpass that,secreted
R2489 T3122 T3123 advmod most,putative
R2490 T3105 T3108 aux can,secreted
R2491 T3106 T3108 auxpass be,secreted
R2492 T3107 T3108 advmod actively,secreted
R2493 T3123 T3126 amod putative,ligands
R2494 T3108 T3103 relcl secreted,component
R2495 T3109 T3108 agent by,secreted
R2496 T3110 T3109 pobj macrophages,by
R2497 T3124 T3126 amod endogenous,ligands
R2498 T3111 T3110 cc or,macrophages
R2499 T3112 T3113 advmod passively,released
R2500 T3113 T3110 acl released,macrophages
R2501 T3125 T3126 nummod TLR4,ligands
R2502 T3114 T3113 agent by,released
R2503 T3126 T3120 pobj ligands,of
R2504 T3127 T3126 acl involved,ligands
R2505 T3115 T3116 amod necrotic,cells
R2506 T3116 T3114 pobj cells,by
R2507 T3128 T3127 prep in,involved
R2508 T3129 T3130 compound RA,pathology
R2509 T3130 T3128 pobj pathology,in
R2510 T3131 T3118 punct .,is
R2511 T3132 T3134 nsubjpass HMGB1,increased
R2512 T3214 T3210 relcl involved,ligands
R2513 T3215 T3214 prep in,involved
R2514 T3133 T3134 auxpass is,increased
R2515 T3216 T3217 compound RA,pathology
R2516 T3217 T3215 pobj pathology,in
R2517 T3218 T3218 ROOT are,are
R2518 T3134 T3134 ROOT increased,increased
R2519 T3219 T3221 amod extracellular,components
R2520 T3220 T3221 compound matrix,components
R2521 T3135 T3134 prep in,increased
R2522 T3221 T3218 attr components,are
R2523 T3222 T3223 amod such,as
R2524 T3223 T3221 prep as,components
R2525 T3136 T3138 nmod RA,tissue
R2526 T3224 T3223 pobj fibrinogen,as
R2527 T3225 T3224 punct ",",fibrinogen
R2528 T3137 T3138 amod synovial,tissue
R2529 T3226 T3224 conj fibronectin,fibrinogen
R2530 T3227 T3226 punct ",",fibronectin
R2531 T3228 T3226 conj biglycan,fibronectin
R2532 T3138 T3135 pobj tissue,in
R2533 T3229 T3228 punct ",",biglycan
R2534 T3230 T3231 compound tenascin,C
R2535 T3231 T3228 conj C,biglycan
R2536 T3139 T3138 cc and,tissue
R2537 T3232 T3231 punct ",",C
R2538 T3233 T3231 cc and,C
R2539 T3234 T3236 amod hyal-uronic,fragments
R2540 T3140 T3141 nsubj HMGB1,neutralising
R2541 T3235 T3236 compound acid,fragments
R2542 T3236 T3231 conj fragments,C
R2543 T3237 T3236 punct (,fragments
R2544 T3141 T3138 conj neutralising,tissue
R2545 T3238 T3236 acl reviewed,fragments
R2546 T3239 T3238 prep in,reviewed
R2547 T3142 T3141 dobj antibodies,neutralising
R2548 T3240 T3239 pobj [,in
R2549 T3241 T3242 nummod "14,15",]
R2550 T3143 T3142 cc or,antibodies
R2551 T3242 T3240 appos ],[
R2552 T3243 T3240 punct ),[
R2553 T3244 T3218 punct .,are
R2554 T3144 T3147 det the,domain
R2555 T3245 T3249 advmod Together,suggest
R2556 T3246 T3249 punct ",",suggest
R2557 T3247 T3248 det these,studies
R2558 T3145 T3147 amod antagonistic,domain
R2559 T3248 T3249 nsubj studies,suggest
R2560 T3249 T3249 ROOT suggest,suggest
R2561 T3250 T3260 mark that,contribute
R2562 T3146 T3147 compound BoxA,domain
R2563 T3251 T3253 amod several,ligands
R2564 T3252 T3253 compound TLR,ligands
R2565 T3253 T3260 nsubj ligands,contribute
R2566 T3147 T3142 conj domain,antibodies
R2567 T3254 T3253 prep in,ligands
R2568 T3255 T3258 det the,tissue
R2569 T3256 T3258 amod inflamed,tissue
R2570 T3148 T3147 prep of,domain
R2571 T3257 T3258 amod joint,tissue
R2572 T3258 T3254 pobj tissue,in
R2573 T3259 T3260 aux may,contribute
R2574 T3149 T3148 pobj HMGB1,of
R2575 T3260 T3249 ccomp contribute,suggest
R2576 T3261 T3260 prep to,contribute
R2577 T3262 T3263 amod NF-κB,activation
R2578 T3263 T3261 pobj activation,to
R2579 T3264 T3263 cc and,activation
R2580 T3265 T3267 amod inflammatory,expression
R2581 T3150 T3134 conj protect,increased
R2582 T3266 T3267 compound gene,expression
R2583 T3267 T3263 conj expression,activation
R2584 T3268 T3263 prep in,activation
R2585 T3151 T3150 prep against,protect
R2586 T3269 T3268 pobj RA,in
R2587 T3270 T3249 punct .,suggest
R2588 T3152 T3153 amod collagen-induced,arthritis
R2589 T3153 T3151 pobj arthritis,against
R2590 T3154 T3153 prep in,arthritis
R2591 T3155 T3154 pobj mice,in
R2592 T3156 T3158 nmod [,]
R2593 T3157 T3158 nummod 16,]
R2594 T3158 T3158 ROOT ],]
R2595 T3159 T3134 punct .,increased
R2596 T3160 T3161 amod Myeloid-related,protein
R2597 T3161 T3181 nsubj protein,are
R2598 T3162 T3161 nummod 8,protein
R2599 T3163 T3161 cc and,protein
R2600 T3164 T3165 amod myeloid-related,protein
R2601 T3165 T3161 conj protein,protein
R2602 T3166 T3165 nummod 14,protein
R2603 T3167 T3165 punct ",",protein
R2604 T3168 T3171 amod damage-associated,molecules
R2605 T3169 T3170 amod molecular,pattern
R2606 T3170 T3171 compound pattern,molecules
R2607 T3171 T3165 conj molecules,protein
R2608 T3172 T3171 acl belonging,molecules
R2609 T3173 T3172 prep to,belonging
R2610 T3174 T3176 det the,family
R2611 T3175 T3176 compound S100,family
R2615 T3176 T3173 pobj family,to
R2620 T3177 T3176 prep of,family
R2622 T3178 T3179 amod calcium-binding,proteins
R2624 T3179 T3177 pobj proteins,of
R2625 T3180 T3181 punct ",",are
R2626 T3181 T3181 ROOT are,are
R2631 T3182 T3181 advmod also,are
R2632 T3183 T3184 advmod abundantly,present
R2634 T3184 T3181 acomp present,are
R2635 T3185 T3184 prep in,present
R2636 T3186 T3188 nmod RA,fluid
R2639 T3187 T3188 compound synovial,fluid
R2640 T3188 T3185 pobj fluid,in
R2641 T3189 T3181 punct ",",are
R2642 T3190 T3181 cc and,are
R2643 T3191 T3193 aux have,suggested
R2644 T3192 T3193 auxpass been,suggested
R2645 T3193 T3181 conj suggested,are
R2646 T3194 T3196 aux to,involved
R2647 T3195 T3196 auxpass be,involved
R2649 T3196 T3193 xcomp involved,suggested
R2650 T3197 T3196 prep in,involved
R2651 T3198 T3200 amod TLR4-induced,inflammation
R2653 T3199 T3200 amod chronic,inflammation
R2655 T3200 T3197 pobj inflammation,in
R2657 T3201 T3200 prep in,inflammation
R2659 T3202 T3203 compound RA,[
R2660 T3203 T3201 pobj [,in
R2661 T3204 T3205 nummod "17,18",]
R2665 T3205 T3193 conj ],suggested
R2668 T3206 T3181 punct .,are
R2669 T3207 T3210 amod Other,ligands
R2674 T3208 T3210 amod endogenous,ligands
R2677 T3209 T3210 compound TLR,ligands
R2678 T3210 T3218 nsubj ligands,are
R2679 T3211 T3214 nsubjpass that,involved
R2680 T3212 T3214 aux may,involved
R2681 T3213 T3214 auxpass be,involved
R3979 T5917 T5918 compound NF-κB,proteins
R3980 T5918 T5920 nsubjpass proteins,sequestered
R3981 T5919 T5920 auxpass are,sequestered
R3982 T5920 T5920 ROOT sequestered,sequestered
R3983 T5921 T5920 prep in,sequestered
R3984 T5922 T5923 det the,cytoplasm
R3985 T5923 T5921 pobj cytoplasm,in
R3986 T5924 T5920 prep as,sequestered
R3987 T5925 T5926 amod latent,complexes
R3988 T5926 T5924 pobj complexes,as
R3989 T5927 T5920 agent by,sequestered
R3990 T5928 T5929 amod inhibitory,proteins
R3991 T5929 T5927 pobj proteins,by
R3992 T5930 T5920 conj referred,sequestered
R3993 T5931 T5930 prep to,referred
R3994 T5932 T5930 prep as,referred
R3995 T5933 T5932 pobj inhibitor,as
R3996 T5934 T5933 prep of,inhibitor
R3997 T5935 T5934 pobj NF-κB,of
R3998 T5936 T5935 punct (,NF-κB
R3999 T5937 T5935 appos IκB,NF-κB
R4000 T5957 T5956 pobj IκBs,of
R4001 T5938 T5935 punct ),NF-κB
R4002 T5958 T5973 punct (,p100
R4003 T5959 T5973 nmod IκBα,p100
R4004 T5939 T5934 pobj proteins,of
R4005 T5960 T5959 punct ",",IκBα
R4006 T5961 T5959 conj IκBβ,IκBα
R4007 T5962 T5961 punct ",",IκBβ
R4008 T5940 T5939 punct ",",proteins
R4009 T5963 T5961 conj IκBε,IκBβ
R4010 T5964 T5963 punct ",",IκBε
R4011 T5965 T5963 conj p105,IκBε
R4012 T5941 T5942 nsubj which,prevent
R4013 T5966 T5965 punct (,p105
R4014 T5967 T5968 advmod also,known
R4015 T5968 T5965 acl known,p105
R4016 T5942 T5939 relcl prevent,proteins
R4017 T5969 T5968 prep as,known
R4018 T5970 T5969 pobj NF-κB1,as
R4019 T5943 T5945 amod NF-κB,translocation
R4020 T5944 T5945 amod nuclear,translocation
R4021 T5945 T5942 dobj translocation,prevent
R4022 T5971 T5965 punct ),p105
R4023 T5972 T5959 punct ",",IκBα
R4024 T5946 T5945 cc and,translocation
R4025 T5973 T5957 appos p100,IκBs
R4026 T5974 T5976 punct (,known
R4027 T5947 T5948 npadvmod DNA,binding
R4028 T5975 T5976 advmod also,known
R4029 T5976 T5973 acl known,p100
R4030 T5977 T5976 prep as,known
R4031 T5948 T5951 amod binding,]
R4032 T5978 T5977 pobj NF-κB2,as
R4033 T5979 T5973 punct ),p100
R4034 T5949 T5951 nmod [,]
R4035 T5980 T5955 punct ),majority
R4036 T5981 T5981 ROOT serve,serve
R4037 T5982 T5981 prep as,serve
R4038 T5983 T5982 pobj inhibitors,as
R4039 T5950 T5951 nummod 19,]
R4040 T5984 T5983 prep of,inhibitors
R4041 T5985 T5984 pobj NF-κB,of
R4042 T5986 T5985 punct ",",NF-κB
R4043 T5987 T5985 conj IκBξ,NF-κB
R4044 T5988 T5987 cc and,IκBξ
R4045 T5989 T5987 conj Bcl-3,IκBξ
R4046 T5951 T5945 conj ],translocation
R4047 T5990 T5993 nmod instead,transactivation
R4048 T5991 T5993 amod potentiate,transactivation
R4049 T5992 T5993 compound NF-κB,transactivation
R4050 T5993 T5983 conj transactivation,inhibitors
R4051 T5952 T5920 punct .,sequestered
R4052 T5994 T5993 prep in,transactivation
R4053 T5995 T5996 det the,nucleus
R4054 T5953 T5981 mark Whereas,serve
R4055 T5996 T5994 pobj nucleus,in
R4056 T5997 T5981 punct .,serve
R4057 T5998 T6001 nsubj p100,are
R4058 T5954 T5955 det the,majority
R4059 T5999 T5998 cc and,p100
R4060 T6000 T5998 conj p105,p100
R4061 T6001 T6001 ROOT are,are
R4062 T6002 T6001 attr precursors,are
R4063 T5955 T5981 nsubj majority,serve
R4064 T6003 T6002 prep of,precursors
R4065 T6004 T6005 det the,p52
R4066 T5956 T5955 prep of,majority
R4067 T6005 T6009 nummod p52,subunits
R4068 T6006 T6005 cc and,p52
R4069 T6007 T6005 conj p50,p52
R4070 T6008 T6009 amod NF-κB,subunits
R4071 T6054 T6055 amod many,stimuli
R4072 T6009 T6003 pobj subunits,of
R4073 T6010 T6009 punct ",",subunits
R4074 T6011 T6001 advmod respectively,are
R4075 T6012 T6001 punct .,are
R4076 T6013 T6014 expl There,are
R4077 T6014 T6014 ROOT are,are
R4078 T6015 T6019 nummod two,pathways
R4079 T6055 T6053 pobj stimuli,by
R4080 T6016 T6019 amod unique,pathways
R4081 T6017 T6018 npadvmod NF-κB,signalling
R4082 T6018 T6019 amod signalling,pathways
R4083 T6019 T6014 attr pathways,are
R4084 T6056 T6055 prep including,stimuli
R4085 T6020 T6019 punct ",",pathways
R4086 T6021 T6019 acl termed,pathways
R4087 T6022 T6021 oprd canonical,termed
R4088 T6057 T6058 amod proinflammatory,cytokines
R4089 T6023 T6022 punct (,canonical
R4090 T6024 T6022 cc or,canonical
R4091 T6058 T6056 pobj cytokines,including
R4092 T6059 T6058 punct (,cytokines
R4093 T6025 T6022 conj classical,canonical
R4094 T6026 T6019 punct ),pathways
R4095 T6027 T6014 cc and,are
R4096 T6028 T6014 conj noncanonical,are
R4097 T6029 T6028 punct (,noncanonical
R4098 T6030 T6028 cc or,noncanonical
R4099 T6060 T6058 prep for,cytokines
R4100 T6031 T6028 conj alternative,noncanonical
R4101 T6032 T6028 punct ),noncanonical
R4102 T6061 T6060 pobj example,for
R4103 T6033 T6034 compound NF-κB,pathways
R4104 T6034 T6014 attr pathways,are
R4105 T6062 T6068 punct ",",antigens
R4106 T6035 T6014 punct .,are
R4107 T6036 T6039 det The,pathway
R4108 T6037 T6039 amod canonical,pathway
R4109 T6063 T6068 nmod TNF,antigens
R4110 T6038 T6039 compound NF-κB,pathway
R4111 T6039 T6040 nsubj pathway,plays
R4112 T6040 T6040 ROOT plays,plays
R4113 T6041 T6043 det a,role
R4114 T6064 T6063 punct ",",TNF
R4115 T6042 T6043 amod major,role
R4116 T6043 T6040 dobj role,plays
R4117 T6044 T6043 prep in,role
R4118 T6065 T6063 conj IL-1,TNF
R4119 T6045 T6048 amod innate,immunity
R4120 T6046 T6045 cc and,innate
R4121 T6047 T6045 conj adaptive,innate
R4122 T6066 T6065 punct ),IL-1
R4123 T6048 T6044 pobj immunity,in
R4124 T6049 T6040 punct ",",plays
R4125 T6050 T6040 cc and,plays
R4126 T6067 T6065 punct ",",IL-1
R4127 T6051 T6052 auxpass is,triggered
R4128 T6052 T6040 conj triggered,plays
R4129 T6053 T6052 agent by,triggered
R4130 T6068 T6058 conj antigens,cytokines
R4131 T6069 T6068 punct ",",antigens
R4132 T6070 T6068 conj RANKL,antigens
R4133 T6071 T6070 punct ",",RANKL
R4134 T6151 T6150 punct ),IKKβ
R4135 T6072 T6070 cc and,RANKL
R4136 T6152 T6146 cc and,known
R4137 T6153 T6155 det the,subunit
R4138 T6073 T6070 conj TLR,RANKL
R4139 T6154 T6155 amod regulatory,subunit
R4140 T6155 T6146 conj subunit,known
R4141 T6156 T6158 nmod NF-κB,modulator
R4142 T6074 T6070 conj ligands,RANKL
R4143 T6157 T6158 amod essential,modulator
R4144 T6158 T6155 appos modulator,subunit
R4145 T6159 T6163 punct (,known
R4146 T6160 T6163 punct NEMO,known
R4147 T6161 T6163 punct -,known
R4148 T6162 T6163 advmod also,known
R4149 T6075 T6040 punct .,plays
R4150 T6163 T6155 acl known,subunit
R4151 T6164 T6163 prep as,known
R4152 T6165 T6164 pobj IKKγ,as
R4153 T6076 T6077 amod NF-κB,signalling
R4154 T6166 T6140 punct ),subunits
R4155 T6167 T6168 punct (,Figure
R4156 T6077 T6082 nsubj signalling,requires
R4157 T6168 T6140 appos Figure,subunits
R4158 T6169 T6168 nummod 1,Figure
R4159 T6078 T6077 acl initiated,signalling
R4160 T6170 T6168 punct ),Figure
R4161 T6171 T6135 punct .,comprised
R4162 T6172 T6174 compound Gene,experiments
R4163 T6173 T6174 compound targeting,experiments
R4164 T6079 T6078 agent by,initiated
R4165 T6174 T6175 nsubj experiments,showed
R4166 T6175 T6175 ROOT showed,showed
R4167 T6176 T6186 mark that,required
R4168 T6080 T6081 amod different,receptors
R4169 T6177 T6186 nsubjpass IKK2,required
R4170 T6178 T6177 cc and,IKK2
R4171 T6081 T6079 pobj receptors,by
R4172 T6082 T6082 ROOT requires,requires
R4173 T6179 T6177 conj NEMO,IKK2
R4174 T6180 T6177 punct ",",IKK2
R4175 T6181 T6177 cc but,IKK2
R4176 T6083 T6084 det the,formation
R4177 T6182 T6183 neg not,IKK1
R4178 T6183 T6177 conj IKK1,IKK2
R4179 T6184 T6186 punct ",",required
R4180 T6185 T6186 auxpass are,required
R4181 T6084 T6082 dobj formation,requires
R4182 T6186 T6175 ccomp required,showed
R4183 T6085 T6084 prep of,formation
R4184 T6187 T6186 prep for,required
R4185 T6086 T6088 amod proximal,interactions
R4186 T6188 T6190 amod canonical,activation
R4187 T6087 T6088 compound protein-protein,interactions
R4188 T6189 T6190 compound NF-κB,activation
R4189 T6190 T6187 pobj activation,for
R4190 T6088 T6085 pobj interactions,of
R4191 T6191 T6193 nmod [,]
R4192 T6192 T6193 nummod 21,]
R4193 T6193 T6190 appos ],activation
R4194 T6194 T6175 punct .,showed
R4195 T6195 T6203 nsubj One,is
R4196 T6196 T6195 prep of,One
R4197 T6089 T6090 nsubj that,are
R4198 T6197 T6198 det the,best
R4199 T6198 T6199 advmod best,studied
R4200 T6199 T6200 amod studied,NF-κB
R4201 T6090 T6088 relcl are,interactions
R4202 T6200 T6201 nsubj NF-κB,signalling
R4203 T6201 T6203 csubj signalling,is
R4204 T6202 T6201 dobj pathways,signalling
R4205 T6091 T6090 advmod often,are
R4206 T6203 T6203 ROOT is,is
R4207 T6204 T6206 det the,pathway
R4208 T6205 T6206 compound TNF,pathway
R4209 T6092 T6093 npadvmod receptor,specific
R4210 T6206 T6203 attr pathway,is
R4211 T6207 T6203 punct .,is
R4212 T6093 T6090 acomp specific,are
R4213 T6208 T6210 compound TNF,results
R4214 T6209 T6210 compound stimulation,results
R4215 T6210 T6210 ROOT results,results
R4216 T6094 T6082 punct ",",requires
R4217 T6211 T6210 prep in,results
R4218 T6212 T6213 det the,recruitment
R4219 T6213 T6211 pobj recruitment,in
R4220 T6095 T6082 cc but,requires
R4221 T6214 T6213 prep of,recruitment
R4222 T6215 T6218 nmod TNF,domain
R4223 T6216 T6218 amod receptor-1-associated,domain
R4224 T6096 T6097 advmod ultimately,converge
R4225 T6217 T6218 compound death,domain
R4226 T6218 T6214 pobj domain,of
R4227 T6219 T6218 punct (,domain
R4228 T6097 T6082 conj converge,requires
R4229 T6220 T6218 appos TRADD,domain
R4230 T6221 T6220 punct ),TRADD
R4231 T6222 T6218 conj protein,domain
R4232 T6098 T6097 prep in,converge
R4233 T6223 T6214 cc and,of
R4234 T6224 T6214 conj of,of
R4235 T6225 T6227 compound receptor,protein
R4236 T6099 T6100 det the,activation
R4237 T6226 T6227 compound interacting,protein
R4238 T6227 T6224 pobj protein,of
R4239 T6228 T6227 nummod 1,protein
R4240 T6100 T6098 pobj activation,in
R4241 T6229 T6227 punct (,protein
R4242 T6230 T6227 appos RIP1,protein
R4243 T6231 T6230 punct ),RIP1
R4244 T6232 T6227 punct ",",protein
R4245 T6233 T6234 nsubj which,function
R4246 T6234 T6210 relcl function,results
R4247 T6101 T6100 prep of,activation
R4248 T6235 T6234 prep as,function
R4249 T6236 T6237 compound adaptor,proteins
R4250 T6237 T6235 pobj proteins,as
R4251 T6238 T6234 prep for,function
R4252 T6102 T6104 det the,kinase
R4253 T6239 T6245 det the,factor
R4254 T6240 T6241 nummod E3,ubiquitin
R4255 T6103 T6104 compound IκB,kinase
R4256 T6241 T6242 nsubj ubiquitin,ligases
R4257 T6242 T6245 nmod ligases,factor
R4258 T6243 T6245 nmod TNF,factor
R4259 T6104 T6101 pobj kinase,of
R4260 T6244 T6245 amod receptor-associated,factor
R4261 T6245 T6238 pobj factor,for
R4262 T6105 T6106 punct (,IKK
R4263 T6246 T6247 punct (,TRAF
R4264 T6247 T6245 appos TRAF,factor
R4265 T6106 T6104 appos IKK,kinase
R4266 T6107 T6106 punct ),IKK
R4267 T6108 T6104 conj complex,kinase
R4268 T6109 T6104 punct ",",kinase
R4269 T6248 T6247 punct ),TRAF
R4270 T6249 T6247 nummod 2,TRAF
R4271 T6110 T6111 nsubj which,mediates
R4272 T6250 T6247 cc and,TRAF
R4273 T6251 T6247 conj TRAF5,TRAF
R4274 T6252 T6245 punct ",",factor
R4275 T6111 T6104 relcl mediates,kinase
R4276 T6253 T6256 nsubj which,bind
R4277 T6254 T6256 prep in,bind
R4278 T6255 T6254 pobj turn,in
R4279 T6112 T6111 dobj phosphorylation,mediates
R4280 T6256 T6245 relcl bind,factor
R4281 T6113 T6112 prep of,phosphorylation
R4282 T6114 T6117 det the,protein
R4283 T6257 T6260 dobj the,ligases
R4284 T6258 T6259 nummod E3,ubiquitin
R4285 T6115 T6117 amod inhibitory,protein
R4286 T6259 T6260 nsubj ubiquitin,ligases
R4287 T6260 T6256 dative ligases,bind
R4288 T6261 T6262 amod cellular,inhibitor
R4289 T6116 T6117 compound IκB,protein
R4290 T6262 T6256 dobj inhibitor,bind
R4291 T6263 T6262 prep of,inhibitor
R4292 T6117 T6113 pobj protein,of
R4293 T6264 T6263 pobj apoptosis,of
R4294 T6265 T6266 punct (,cIAP
R4295 T6266 T6264 appos cIAP,apoptosis
R4296 T6267 T6256 punct ),bind
R4297 T6268 T6256 nummod 1,bind
R4298 T6118 T6117 acl leading,protein
R4299 T6269 T6256 cc and,bind
R4300 T6270 T6274 nmod cIAP2,)
R4301 T6271 T6272 punct (,Figure
R4302 T6119 T6118 prep to,leading
R4303 T6272 T6270 appos Figure,cIAP2
R4304 T6273 T6272 nummod 1,Figure
R4305 T6274 T6256 conj ),bind
R4306 T6275 T6210 punct .,results
R4307 T6120 T6121 poss its,K48-polyubiquitination
R4308 T6276 T6285 prep On,modified
R4309 T6277 T6278 compound TNF,stimulation
R4310 T6121 T6119 pobj K48-polyubiquitination,to
R4311 T6278 T6276 pobj stimulation,On
R4312 T6279 T6285 punct ",",modified
R4313 T6280 T6282 amod TNF-receptor,RIP1
R4314 T6122 T6121 cc and,K48-polyubiquitination
R4315 T6281 T6282 amod bound,RIP1
R4316 T6282 T6285 nsubjpass RIP1,modified
R4317 T6283 T6285 auxpass is,modified
R4318 T6123 T6121 conj degradation,K48-polyubiquitination
R4319 T6284 T6285 advmod rapidly,modified
R4320 T6285 T6285 ROOT modified,modified
R4321 T6124 T6121 prep by,K48-polyubiquitination
R4322 T6286 T6285 agent by,modified
R4323 T6287 T6289 amod K63-linked,chains
R4324 T6288 T6289 compound polyubiquitin,chains
R4325 T6125 T6129 det the,]
R4326 T6289 T6286 pobj chains,by
R4327 T6290 T6285 punct .,modified
R4328 T6291 T6294 nsubj TRAF2/5,are
R4329 T6126 T6127 compound proteasome,[
R4330 T6292 T6291 cc and,TRAF2/5
R4331 T6293 T6291 conj cIAP1/2,TRAF2/5
R4332 T6127 T6129 nmod [,]
R4333 T6294 T6294 ROOT are,are
R4334 T6295 T6296 amod good,candidates
R4335 T6296 T6294 attr candidates,are
R4336 T6128 T6129 nummod 20,]
R4337 T6297 T6296 prep for,candidates
R4338 T6298 T6299 compound RIP1,ubiquitination
R4339 T6299 T6297 pobj ubiquitination,for
R4340 T6129 T6124 pobj ],by
R4341 T6300 T6294 punct ",",are
R4342 T6301 T6294 cc but,are
R4343 T6130 T6082 punct .,requires
R4344 T6302 T6304 det the,role
R4345 T6303 T6304 amod specific,role
R4346 T6304 T6307 nsubj role,is
R4347 T6305 T6304 prep of,role
R4348 T6306 T6305 pobj each,of
R4349 T6307 T6294 conj is,are
R4350 T6131 T6133 det The,complex
R4351 T6308 T6307 advmod still,is
R4352 T6309 T6307 acomp unclear,is
R4353 T6310 T6307 punct .,is
R4354 T6132 T6133 compound IKK,complex
R4355 T6311 T6313 det The,chains
R4356 T6312 T6313 compound polyubiquitin,chains
R4357 T6313 T6317 nsubjpass chains,believed
R4358 T6133 T6135 nsubjpass complex,comprised
R4359 T6314 T6313 prep on,chains
R4360 T6315 T6314 pobj RIP1,on
R4361 T6134 T6135 auxpass is,comprised
R4362 T6316 T6317 auxpass are,believed
R4363 T6317 T6317 ROOT believed,believed
R4364 T6318 T6319 aux to,create
R4365 T6135 T6135 ROOT comprised,comprised
R4366 T6319 T6317 xcomp create,believed
R4367 T6320 T6321 det a,scaffold
R4368 T6321 T6319 dobj scaffold,create
R4369 T6136 T6135 prep of,comprised
R4370 T6322 T6323 aux to,recruit
R4371 T6323 T6319 advcl recruit,create
R4372 T6137 T6140 det the,subunits
R4373 T6324 T6325 det the,IKK
R4374 T6325 T6323 dobj IKK,recruit
R4375 T6326 T6325 cc and,IKK
R4376 T6138 T6140 nummod two,subunits
R4377 T6327 T6328 nummod TAK1,complex
R4378 T6328 T6317 conj complex,believed
R4379 T6139 T6140 amod catalytic,subunits
R4380 T6329 T6328 prep via,complex
R4381 T6330 T6332 det the,proteins
R4382 T6331 T6332 amod ubiquitin-binding,proteins
R4383 T6332 T6329 pobj proteins,via
R4384 T6140 T6136 pobj subunits,of
R4385 T6333 T6332 appos NEMO,proteins
R4386 T6334 T6333 cc and,NEMO
R4387 T6141 T6140 appos IKK1,subunits
R4388 T6335 T6333 conj TAB1/2,NEMO
R4389 T6142 T6141 cc and,IKK1
R4390 T6143 T6141 conj IKK2,IKK1
R4391 T6336 T6335 punct ",",TAB1/2
R4392 T6337 T6333 conj respectively,NEMO
R4393 T6144 T6146 punct (,known
R4394 T6338 T6317 punct .,believed
R4395 T6339 T6341 det The,identification
R4396 T6340 T6341 amod recent,identification
R4397 T6341 T6356 nsubj identification,is
R4398 T6342 T6341 prep of,identification
R4399 T6343 T6347 det a,complex
R4400 T6145 T6146 advmod also,known
R4401 T6344 T6347 amod distinct,complex
R4402 T6146 T6141 parataxis known,IKK1
R4403 T6147 T6146 prep as,known
R4404 T6148 T6147 pobj IKKα,as
R4405 T6345 T6346 nummod E2/E3,enzyme
R4406 T6346 T6347 compound enzyme,complex
R4407 T6149 T6148 cc and,IKKα
R4408 T6347 T6342 pobj complex,of
R4409 T6348 T6349 nsubj that,modifies
R4410 T6349 T6347 relcl modifies,complex
R4411 T6150 T6148 conj IKKβ,IKKα
R4412 T6350 T6349 dobj NEMO,modifies
R4413 T6351 T6349 prep with,modifies
R4414 T6442 T6443 amod bridging,factors
R4415 T6352 T6354 amod linear,chains
R4416 T6353 T6354 compound polyubiquitin,chains
R4417 T6354 T6351 pobj chains,with
R4418 T6355 T6349 cc and,modifies
R4419 T6356 T6362 ccomp is,adds
R4420 T6357 T6356 acomp essential,is
R4421 T6443 T6441 pobj factors,as
R4422 T6358 T6357 prep for,essential
R4423 T6359 T6361 amod TNF-activated,signalling
R4424 T6444 T6445 aux to,recruit
R4425 T6360 T6361 compound NF-κB,signalling
R4426 T6361 T6358 pobj signalling,for
R4427 T6362 T6362 ROOT adds,adds
R4428 T6363 T6364 amod further,complexity
R4429 T6445 T6440 advcl recruit,serve
R4430 T6364 T6362 dobj complexity,adds
R4431 T6365 T6367 nmod [,]
R4432 T6366 T6367 nummod 22,]
R4433 T6446 T6450 amod myeloid,gene
R4434 T6367 T6362 npadvmod ],adds
R4435 T6368 T6362 punct .,adds
R4436 T6369 T6371 det The,role
R4437 T6447 T6450 nmod differentiation,gene
R4438 T6370 T6371 amod exact,role
R4439 T6371 T6376 nsubj role,remains
R4440 T6448 T6450 amod primary,gene
R4441 T6372 T6371 prep of,role
R4442 T6373 T6375 amod protein-anchored,chains
R4443 T6374 T6375 compound polyubiquitin,chains
R4444 T6375 T6372 pobj chains,of
R4445 T6449 T6450 compound response,gene
R4446 T6376 T6376 ROOT remains,remains
R4447 T6377 T6376 acomp unclear,remains
R4448 T6378 T6376 punct ",",remains
R4449 T6379 T6383 mark as,suggested
R4450 T6380 T6383 nsubjpass it,suggested
R4451 T6381 T6383 auxpass was,suggested
R4452 T6450 T6445 dobj gene,recruit
R4453 T6382 T6383 advmod recently,suggested
R4454 T6383 T6376 advcl suggested,remains
R4455 T6384 T6390 mark that,activate
R4456 T6451 T6450 nummod 88,gene
R4457 T6385 T6387 amod unanchored,chains
R4458 T6386 T6387 compound polyubiquitin,chains
R4459 T6387 T6390 nsubj chains,activate
R4460 T6388 T6390 aux can,activate
R4461 T6452 T6453 punct (,MyD88
R4462 T6389 T6390 advmod directly,activate
R4463 T6390 T6383 ccomp activate,suggested
R4464 T6391 T6396 det the,]
R4465 T6453 T6450 appos MyD88,gene
R4466 T6392 T6396 nummod TAK1,]
R4467 T6393 T6394 amod complex,[
R4468 T6394 T6396 nmod [,]
R4469 T6454 T6453 punct ),MyD88
R4470 T6395 T6396 nummod 23,]
R4471 T6396 T6390 dobj ],activate
R4472 T6455 T6440 cc and,serve
R4473 T6397 T6376 punct .,remains
R4474 T6398 T6400 amod Similar,principles
R4475 T6399 T6400 amod signalling,principles
R4476 T6456 T6459 compound TIR,IFNβ
R4477 T6400 T6401 nsubj principles,apply
R4478 T6401 T6401 ROOT apply,apply
R4479 T6402 T6401 prep to,apply
R4480 T6457 T6459 compound domain-containing,IFNβ
R4481 T6403 T6404 amod other,receptors
R4482 T6404 T6402 pobj receptors,to
R4483 T6405 T6401 punct .,apply
R4484 T6458 T6459 compound adaptor-inducing,IFNβ
R4485 T6406 T6413 prep For,induces
R4486 T6407 T6406 pobj example,For
R4487 T6408 T6413 punct ",",induces
R4488 T6459 T6432 appos IFNβ,molecule
R4489 T6409 T6410 nummod TLR4,stimulation
R4490 T6410 T6413 nsubj stimulation,induces
R4491 T6411 T6410 prep by,stimulation
R4492 T6460 T6459 punct (,IFNβ
R4493 T6412 T6411 pobj lipopolysaccharide,by
R4494 T6413 T6413 ROOT induces,induces
R4495 T6461 T6459 appos TRIF,IFNβ
R4496 T6414 T6415 det the,recruitment
R4497 T6415 T6413 dobj recruitment,induces
R4498 T6416 T6415 prep of,recruitment
R4499 T6462 T6459 punct ),IFNβ
R4500 T6417 T6421 nmod Toll/IL,protein
R4501 T6418 T6421 nummod -1,protein
R4502 T6419 T6420 compound receptor,adaptor
R4503 T6420 T6421 compound adaptor,protein
R4504 T6463 T6459 punct ",",IFNβ
R4505 T6421 T6416 pobj protein,of
R4506 T6422 T6424 punct (,referred
R4507 T6464 T6459 advmod respectively,IFNβ
R4508 T6423 T6424 advmod also,referred
R4509 T6424 T6424 ROOT referred,referred
R4510 T6425 T6424 prep to,referred
R4511 T6465 T6424 punct .,referred
R4512 T6426 T6425 prep as,to
R4513 T6427 T6426 pobj Mal,as
R4514 T6428 T6425 punct ),to
R4515 T6466 T6469 nummod MyD88,recruits
R4516 T6429 T6424 cc and,referred
R4517 T6430 T6432 amod TRIF-related,molecule
R4518 T6431 T6432 compound adaptor,molecule
R4519 T6467 T6469 prep in,recruits
R4520 T6432 T6424 conj molecule,referred
R4521 T6433 T6434 punct (,TRAM
R4522 T6468 T6467 pobj turn,in
R4523 T6434 T6432 appos TRAM,molecule
R4524 T6435 T6434 punct ),TRAM
R4525 T6436 T6432 punct ",",molecule
R4526 T6469 T6469 ROOT recruits,recruits
R4527 T6437 T6440 nsubj which,serve
R4528 T6438 T6439 advmod most,probably
R4529 T6439 T6440 advmod probably,serve
R4530 T6440 T6432 relcl serve,molecule
R4531 T6470 T6469 dobj members,recruits
R4532 T6441 T6440 prep as,serve
R4533 T6471 T6470 prep of,members
R4534 T6472 T6474 det the,kinase
R4535 T6473 T6474 amod IL-1R-associated,kinase
R4536 T6539 T6542 det the,receptor
R4537 T6540 T6542 nmod lymphotoxin,receptor
R4538 T6474 T6471 pobj kinase,of
R4539 T6541 T6542 compound β,receptor
R4540 T6542 T6538 pobj receptor,by
R4541 T6475 T6474 punct (,kinase
R4542 T6543 T6542 punct ",",receptor
R4543 T6544 T6545 compound BAFF,receptor
R4544 T6545 T6542 conj receptor,receptor
R4545 T6476 T6474 appos IRAK,kinase
R4546 T6546 T6545 punct ",",receptor
R4547 T6547 T6545 conj CD40,receptor
R4548 T6548 T6547 punct ",",CD40
R4549 T6549 T6547 cc and,CD40
R4550 T6550 T6547 conj RANK,CD40
R4551 T6551 T6552 punct (,Figure
R4552 T6552 T6550 appos Figure,RANK
R4553 T6477 T6476 punct ),IRAK
R4554 T6478 T6474 conj family,kinase
R4555 T6553 T6552 nummod 2,Figure
R4556 T6479 T6478 cc and,family
R4557 T6554 T6550 punct ),RANK
R4558 T6555 T6537 punct .,activated
R4559 T6480 T6478 conj TRAF6,family
R4560 T6556 T6562 prep In,processed
R4561 T6557 T6558 det this,pathway
R4562 T6481 T6469 punct ",",recruits
R4563 T6558 T6556 pobj pathway,In
R4564 T6559 T6562 punct ",",processed
R4565 T6560 T6562 nsubjpass p100,processed
R4566 T6561 T6562 auxpass is,processed
R4567 T6482 T6469 advcl leading,recruits
R4568 T6562 T6562 ROOT processed,processed
R4569 T6563 T6562 agent by,processed
R4570 T6483 T6482 prep to,leading
R4571 T6564 T6565 det the,proteasome
R4572 T6565 T6563 pobj proteasome,by
R4573 T6566 T6565 prep to,proteasome
R4574 T6484 T6483 pobj oligomerisation,to
R4575 T6567 T6566 pobj p52,to
R4576 T6568 T6567 punct ",",p52
R4577 T6485 T6484 cc and,oligomerisation
R4578 T6569 T6576 nsubj which,regulates
R4579 T6486 T6484 conj selfubiquitination,oligomerisation
R4580 T6570 T6571 advmod together,with
R4581 T6487 T6486 prep of,selfubiquitination
R4582 T6571 T6576 prep with,regulates
R4583 T6572 T6575 det the,subunit
R4584 T6488 T6491 nummod TRAF6,]
R4585 T6573 T6575 compound RelB,subunit
R4586 T6574 T6575 compound NF-κB,subunit
R4587 T6575 T6571 pobj subunit,with
R4588 T6576 T6565 relcl regulates,proteasome
R4589 T6489 T6491 nmod [,]
R4590 T6577 T6579 det a,set
R4591 T6578 T6579 amod distinct,set
R4592 T6490 T6491 nummod 24,]
R4593 T6579 T6576 dobj set,regulates
R4594 T6580 T6579 prep of,set
R4595 T6581 T6582 compound target,genes
R4596 T6491 T6487 pobj ],of
R4597 T6582 T6580 pobj genes,of
R4598 T6583 T6584 nsubj that,control
R4599 T6584 T6582 relcl control,genes
R4600 T6585 T6586 amod B-cell,development
R4601 T6586 T6584 dobj development,control
R4602 T6587 T6586 punct ",",development
R4603 T6588 T6591 amod secondary,development
R4604 T6589 T6591 amod lymphoid,development
R4605 T6492 T6469 punct .,recruits
R4606 T6590 T6591 compound organ,development
R4607 T6591 T6586 conj development,development
R4608 T6592 T6591 punct ",",development
R4609 T6593 T6591 cc and,development
R4610 T6493 T6495 nsubj TRIF,recruits
R4611 T6594 T6595 compound osteoclastogenesis,[
R4612 T6595 T6579 appos [,set
R4613 T6596 T6597 nummod 27,]
R4614 T6494 T6495 advmod also,recruits
R4615 T6597 T6597 ROOT ],]
R4616 T6598 T6601 det The,pathway
R4617 T6599 T6601 amod noncanonical,pathway
R4618 T6495 T6495 ROOT recruits,recruits
R4619 T6600 T6601 compound NF-κB,pathway
R4620 T6601 T6602 nsubj pathway,is
R4621 T6496 T6499 nummod TRAF6,]
R4622 T6602 T6602 ROOT is,is
R4623 T6603 T6604 advmod strictly,dependent
R4624 T6604 T6602 acomp dependent,is
R4625 T6605 T6604 prep on,dependent
R4626 T6497 T6499 nmod [,]
R4627 T6606 T6605 pobj IKK1,on
R4628 T6498 T6499 nummod 25,]
R4629 T6607 T6606 punct ",",IKK1
R4630 T6608 T6610 nsubjpass which,activated
R4631 T6609 T6610 auxpass is,activated
R4632 T6499 T6495 dobj ],recruits
R4633 T6610 T6606 relcl activated,IKK1
R4634 T6611 T6610 prep upon,activated
R4635 T6612 T6611 pobj phosphorylation,upon
R4636 T6613 T6610 agent by,activated
R4637 T6500 T6499 cc and,]
R4638 T6614 T6615 advmod NF-κB,inducing
R4639 T6615 T6613 pcomp inducing,by
R4640 T6616 T6615 dobj kinase,inducing
R4641 T6501 T6502 compound RIP1,[
R4642 T6617 T6618 punct (,NIK
R4643 T6618 T6616 parataxis NIK,kinase
R4644 T6619 T6618 punct ),NIK
R4645 T6502 T6499 conj [,]
R4646 T6620 T6602 punct .,is
R4647 T6621 T6624 nsubjpass NIK,regulated
R4648 T6622 T6624 auxpass is,regulated
R4649 T6623 T6624 advmod predominantly,regulated
R4650 T6624 T6624 ROOT regulated,regulated
R4651 T6625 T6624 prep at,regulated
R4652 T6503 T6504 nummod 26,]
R4653 T6626 T6628 det the,level
R4654 T6627 T6628 amod post-translational,level
R4655 T6628 T6625 pobj level,at
R4656 T6629 T6624 cc and,regulated
R4657 T6504 T6499 conj ],]
R4658 T6630 T6624 conj is,regulated
R4659 T6631 T6630 acomp present,is
R4660 T6632 T6631 prep at,present
R4661 T6505 T6495 prep via,recruits
R4662 T6633 T6634 advmod extremely,low
R4663 T6634 T6635 amod low,levels
R4664 T6506 T6508 det a,interaction
R4665 T6635 T6632 pobj levels,at
R4666 T6507 T6508 amod direct,interaction
R4667 T6508 T6505 pobj interaction,via
R4668 T6636 T6635 prep in,levels
R4669 T6509 T6495 punct .,recruits
R4670 T6637 T6639 amod most,types
R4671 T6638 T6639 compound cell,types
R4672 T6639 T6636 pobj types,in
R4673 T6510 T6511 det Both,pathways
R4674 T6640 T6630 punct .,is
R4675 T6641 T6646 prep In,occurs
R4676 T6511 T6513 nsubj pathways,activate
R4677 T6642 T6643 amod unstimulated,cells
R4678 T6643 T6641 pobj cells,In
R4679 T6644 T6646 punct ",",occurs
R4680 T6512 T6513 advmod then,activate
R4681 T6645 T6646 nsubj NIK,occurs
R4682 T6646 T6646 ROOT occurs,occurs
R4683 T6513 T6513 ROOT activate,activate
R4684 T6647 T6646 prep in,occurs
R4685 T6514 T6513 dobj TAK1,activate
R4686 T6515 T6514 cc and,TAK1
R4687 T6648 T6650 det a,complex
R4688 T6649 T6650 compound cytoplasmic,complex
R4689 T6516 T6514 conj IKK,TAK1
R4690 T6650 T6647 pobj complex,in
R4691 T6651 T6650 prep with,complex
R4692 T6517 T6514 prep in,TAK1
R4693 T6652 T6651 pobj TRAF2,with
R4694 T6653 T6652 punct ",",TRAF2
R4695 T6654 T6652 conj TRAF3,TRAF2
R4696 T6518 T6520 det a,manner
R4697 T6655 T6646 punct ",",occurs
R4698 T6656 T6646 cc and,occurs
R4699 T6657 T6663 nsubj cIAP1/2,leading
R4700 T6658 T6657 punct ",",cIAP1/2
R4701 T6659 T6660 nsubj which,K48-polyubiquitinates
R4702 T6519 T6520 amod ubiquitination-dependent,manner
R4703 T6660 T6657 relcl K48-polyubiquitinates,cIAP1/2
R4704 T6661 T6660 dobj NIK,K48-polyubiquitinates
R4705 T6662 T6657 punct ",",cIAP1/2
R4706 T6520 T6517 pobj manner,in
R4707 T6663 T6646 conj leading,occurs
R4708 T6664 T6663 prep to,leading
R4709 T6665 T6667 poss its,degradation
R4710 T6521 T6520 amod similar,manner
R4711 T6666 T6667 amod continuous,degradation
R4712 T6667 T6664 pobj degradation,to
R4713 T6668 T6667 prep by,degradation
R4714 T6522 T6521 prep to,similar
R4715 T6669 T6670 det the,proteasome
R4716 T6670 T6668 pobj proteasome,by
R4717 T6671 T6663 punct .,leading
R4718 T6523 T6525 det the,pathway
R4719 T6672 T6673 compound Receptor,ligation
R4720 T6673 T6676 nsubjpass ligation,shown
R4721 T6674 T6676 aux has,shown
R4722 T6524 T6525 compound TNF,pathway
R4723 T6675 T6676 auxpass been,shown
R4724 T6676 T6676 ROOT shown,shown
R4725 T6677 T6680 preconj not,remove
R4726 T6525 T6522 pobj pathway,to
R4727 T6678 T6677 advmod only,not
R4728 T6679 T6680 aux to,remove
R4729 T6680 T6676 xcomp remove,shown
R4730 T6526 T6525 punct (,pathway
R4731 T6681 T6680 dobj TRAF3,remove
R4732 T6682 T6680 prep from,remove
R4733 T6683 T6684 det this,complex
R4734 T6527 T6525 appos Figure,pathway
R4735 T6684 T6682 pobj complex,from
R4736 T6685 T6680 prep by,remove
R4737 T6686 T6685 pcomp recruiting,by
R4738 T6528 T6527 nummod 1,Figure
R4739 T6687 T6686 dobj it,recruiting
R4740 T6688 T6686 prep to,recruiting
R4741 T6529 T6525 punct ),pathway
R4742 T6689 T6690 det the,receptor
R4743 T6690 T6688 pobj receptor,to
R4744 T6691 T6680 punct ",",remove
R4745 T6530 T6513 punct .,activate
R4746 T6692 T6680 cc but,remove
R4747 T6693 T6692 advmod also,but
R4748 T6694 T6695 aux to,attract
R4749 T6695 T6680 conj attract,remove
R4750 T6696 T6695 dobj TRAF2,attract
R4751 T6697 T6695 cc and,attract
R4752 T6531 T6534 det The,pathway
R4753 T6698 T6695 conj cIAP1/2,attract
R4754 T6699 T6698 punct ",",cIAP1/2
R4755 T6700 T6701 nsubj which,are
R4756 T6532 T6534 amod noncanonical,pathway
R4757 T6701 T6698 relcl are,cIAP1/2
R4758 T6702 T6701 acomp essential,are
R4759 T6703 T6702 prep for,essential
R4760 T6533 T6534 compound NF-κB,pathway
R4761 T6704 T6706 amod subsequent,degradation
R4762 T6705 T6706 nummod TRAF3,degradation
R4763 T6534 T6537 nsubjpass pathway,activated
R4764 T6706 T6703 pobj degradation,for
R4765 T6707 T6676 punct .,shown
R4766 T6708 T6709 predet All,this
R4767 T6535 T6537 aux can,activated
R4768 T6709 T6710 nsubj this,contributes
R4769 T6710 T6710 ROOT contributes,contributes
R4770 T6536 T6537 auxpass be,activated
R4771 T6711 T6710 prep to,contributes
R4772 T6712 T6711 pcomp releasing,to
R4773 T6713 T6712 dobj NIK,releasing
R4774 T6537 T6537 ROOT activated,activated
R4775 T6714 T6710 prep from,contributes
R4776 T6715 T6717 poss its,degradation
R4777 T6716 T6717 amod constitutive,degradation
R4778 T6538 T6537 agent by,activated
R4779 T6717 T6714 pobj degradation,from
R4780 T6718 T6710 punct ",",contributes
R4781 T6719 T6710 advcl resulting,contributes
R4782 T6733 T6710 punct .,contributes
R4783 T6720 T6719 prep in,resulting
R4784 T6721 T6722 compound NIK,accumulation
R4785 T6722 T6720 pobj accumulation,in
R4786 T6723 T6722 cc and,accumulation
R4787 T6724 T6725 nummod IKK1,phosphorylation
R4788 T6734 T6737 nsubjpass It,mentioned
R4789 T6725 T6728 compound phosphorylation,]
R4790 T6726 T6728 compound [,]
R4791 T6735 T6737 aux should,mentioned
R4792 T6727 T6728 compound "28,29",]
R4793 T6728 T6728 ROOT ],]
R4794 T6736 T6737 auxpass be,mentioned
R4795 T6729 T6730 punct (,Figure
R4796 T6730 T6728 appos Figure,]
R4797 T6731 T6730 nummod 2,Figure
R4798 T6732 T6730 punct ),Figure
R4799 T6737 T6737 ROOT mentioned,mentioned
R4800 T6738 T6746 mark that,mediate
R4801 T6739 T6746 nsubj CD40,mediate
R4802 T6830 T6828 pobj cells,in
R4803 T6831 T6833 nsubjpass TRAF6,required
R4804 T6740 T6739 punct ",",CD40
R4805 T6832 T6833 auxpass is,required
R4806 T6833 T6833 ROOT required,required
R4807 T6834 T6833 prep for,required
R4808 T6835 T6837 amod CD40-mediated,activation
R4809 T6741 T6743 nmod lymphotoxin,receptor
R4810 T6836 T6837 compound JNK,activation
R4811 T6837 T6834 pobj activation,for
R4812 T6742 T6743 compound β,receptor
R4813 T6838 T6837 cc and,activation
R4814 T6839 T6837 conj IL-6,activation
R4815 T6840 T6837 conj production,activation
R4816 T6743 T6739 appos receptor,CD40
R4817 T6841 T6833 punct ",",required
R4818 T6842 T6845 mark while,required
R4819 T6843 T6845 nsubjpass TRAF2,required
R4820 T6744 T6743 cc and,receptor
R4821 T6844 T6845 auxpass is,required
R4822 T6845 T6833 advcl required,required
R4823 T6846 T6845 prep for,required
R4824 T6745 T6743 conj RANK,receptor
R4825 T6847 T6846 pobj activation,for
R4826 T6848 T6847 prep of,activation
R4827 T6849 T6848 pobj NF-κB,of
R4828 T6746 T6737 ccomp mediate,mentioned
R4829 T6850 T6845 punct ",",required
R4830 T6851 T6833 cc and,required
R4831 T6747 T6748 det the,activation
R4832 T6852 T6853 nsubj TRAF3,serves
R4833 T6853 T6833 conj serves,required
R4834 T6854 T6853 prep as,serves
R4835 T6748 T6746 dobj activation,mediate
R4836 T6855 T6857 det a,regulator
R4837 T6856 T6857 amod negative,regulator
R4838 T6749 T6748 prep of,activation
R4839 T6857 T6854 pobj regulator,as
R4840 T6858 T6857 prep of,regulator
R4841 T6859 T6860 nsubj CD40,signalling
R4842 T6750 T6751 preconj both,canonical
R4843 T6860 T6858 pcomp signalling,of
R4844 T6861 T6863 compound [,]
R4845 T6751 T6756 amod canonical,pathways
R4846 T6862 T6863 compound "30,31",]
R4847 T6863 T6860 dobj ],signalling
R4848 T6864 T6853 punct .,serves
R4849 T6752 T6751 cc and,canonical
R4850 T6753 T6751 conj noncanonical,canonical
R4851 T6754 T6755 npadvmod NF-κB,signalling
R4852 T6755 T6756 amod signalling,pathways
R4853 T6756 T6749 pobj pathways,of
R4854 T6757 T6737 punct .,mentioned
R4855 T6758 T6787 prep Upon,leads
R4856 T6759 T6758 pobj binding,Upon
R4857 T6760 T6759 prep of,binding
R4858 T6761 T6762 poss their,ligand
R4859 T6762 T6760 pobj ligand,of
R4860 T6763 T6762 punct ",",ligand
R4861 T6764 T6762 appos CD40,ligand
R4862 T6765 T6764 cc and,CD40
R4863 T6766 T6767 compound RANK,interact
R4864 T6767 T6787 nsubj interact,leads
R4865 T6768 T6767 prep with,interact
R4866 T6769 T6771 amod several,members
R4867 T6770 T6771 compound TRAF,members
R4868 T6771 T6768 pobj members,with
R4869 T6772 T6771 punct ",",members
R4870 T6773 T6771 prep including,members
R4871 T6774 T6773 pobj TRAF1,including
R4872 T6775 T6774 punct ",",TRAF1
R4873 T6776 T6774 conj TRAF2,TRAF1
R4874 T6777 T6771 punct ",",members
R4875 T6778 T6771 appos TRAF3,members
R4876 T6779 T6778 punct ",",TRAF3
R4877 T6780 T6778 conj TRAF5,TRAF3
R4878 T6781 T6767 punct ",",interact
R4879 T6782 T6767 cc and,interact
R4880 T6783 T6767 conj TRAF6,interact
R4881 T6784 T6783 punct ",",TRAF6
R4882 T6785 T6783 cc and,TRAF6
R4883 T6786 T6787 nsubj this,leads
R4884 T6787 T6787 ROOT leads,leads
R4885 T6788 T6787 prep to,leads
R4886 T6789 T6790 det the,proteolysis
R4887 T6790 T6788 pobj proteolysis,to
R4888 T6791 T6790 prep of,proteolysis
R4889 T6792 T6793 det both,TRAF2
R4890 T6793 T6791 pobj TRAF2,of
R4891 T6794 T6793 cc and,TRAF2
R4892 T6795 T6793 conj TRAF3,TRAF2
R4893 T6796 T6790 punct ",",proteolysis
R4894 T6797 T6798 nsubj which,represents
R4895 T6798 T6790 relcl represents,proteolysis
R4896 T6799 T6801 det an,step
R4897 T6800 T6801 amod important,step
R4898 T6801 T6798 dobj step,represents
R4899 T6802 T6801 prep in,step
R4900 T6803 T6804 det the,activation
R4901 T6804 T6802 pobj activation,in
R4902 T6805 T6804 prep of,activation
R4904 T6806 T6808 det the,pathway
R4908 T6807 T6808 amod noncanonical,pathway
R4912 T6808 T6805 pobj pathway,of
R4914 T6809 T6810 mark as,described
R4917 T6810 T6798 advcl described,represents
R4918 T6811 T6810 advmod above,described
R4920 T6812 T6787 punct .,leads
R4921 T6813 T6815 amod Specific,molecules
R4923 T6814 T6815 compound TRAF,molecules
R4926 T6815 T6817 nsubjpass molecules,associated
R4929 T6816 T6817 auxpass are,associated
R4931 T6817 T6817 ROOT associated,associated
R4934 T6818 T6817 prep with,associated
R4938 T6819 T6818 pobj overlapping,with
R4941 T6820 T6819 cc and,overlapping
R4943 T6821 T6823 amod distinct,functions
R4948 T6822 T6823 amod CD40-mediated,functions
R4949 T6823 T6819 conj functions,overlapping
R4950 T6824 T6817 punct .,associated
R4951 T6825 T6833 prep For,required
R4953 T6826 T6825 pobj example,For
R4955 T6827 T6833 punct ",",required
R4957 T6828 T6833 prep in,required
R4958 T6829 T6830 compound B,cells
R5921 T8787 T8790 mark Since,is
R5922 T8788 T8789 compound NF-κB,activation
R5923 T8789 T8790 nsubj activation,is
R5924 T8790 T8811 advcl is,is
R5925 T8791 T8792 advmod so,crucial
R5926 T8792 T8790 acomp crucial,is
R5927 T8793 T8792 prep to,crucial
R5928 T8794 T8796 amod many,processes
R5929 T8795 T8796 amod cellular,processes
R5930 T8796 T8793 pobj processes,to
R5931 T8797 T8811 punct ",",is
R5932 T8798 T8800 det a,regulation
R5933 T8799 T8800 amod tight,regulation
R5934 T8800 T8811 nsubj regulation,is
R5935 T8801 T8800 prep of,regulation
R5936 T8802 T8805 det the,pathway
R5937 T8803 T8805 nmod NF-κB,pathway
R5938 T8804 T8805 amod signalling,pathway
R5939 T8805 T8801 pobj pathway,of
R5940 T8806 T8805 cc and,pathway
R5941 T8807 T8808 det the,genes
R5942 T8808 T8805 conj genes,pathway
R5943 T8809 T8810 nsubj it,induces
R5944 T8810 T8808 relcl induces,genes
R5945 T8811 T8811 ROOT is,is
R5946 T8812 T8814 det an,requirement
R5947 T8813 T8814 amod absolute,requirement
R5948 T8814 T8811 attr requirement,is
R5949 T8815 T8816 aux to,fine-tune
R5950 T8816 T8814 acl fine-tune,requirement
R5951 T8817 T8819 det the,response
R5952 T8818 T8819 amod inflammatory,response
R5953 T8819 T8816 dobj response,fine-tune
R5954 T8820 T8811 punct .,is
R5955 T8821 T8827 advmod Moreover,is
R5956 T8822 T8827 punct ",",is
R5957 T8823 T8827 csubj terminating,is
R5958 T8824 T8826 det an,response
R5959 T8825 T8826 amod NF-κB,response
R5960 T8826 T8823 dobj response,terminating
R5961 T8827 T8827 ROOT is,is
R5962 T8828 T8827 acomp essential,is
R5963 T8829 T8830 aux to,prevent
R5964 T8830 T8827 xcomp prevent,is
R5965 T8831 T8833 amod persistent,activation
R5966 T8832 T8833 compound NF-κB,activation
R5967 T8833 T8830 dobj activation,prevent
R5968 T8834 T8836 nsubj that,lead
R5969 T8835 T8836 aux may,lead
R5970 T8836 T8833 relcl lead,activation
R5971 T8837 T8836 prep to,lead
R5972 T8838 T8839 amod chronic,inflammation
R5973 T8839 T8837 pobj inflammation,to
R5974 T8840 T8839 cc and/or,inflammation
R5975 T8841 T8839 conj tumorigenesis,inflammation
R5976 T8842 T8827 punct .,is
R5977 T8843 T8844 aux To,achieve
R5978 T8844 T8848 advcl achieve,employ
R5979 T8845 T8844 dobj this,achieve
R5980 T8846 T8848 punct ",",employ
R5981 T8847 T8848 nsubj cells,employ
R5982 T8848 T8848 ROOT employ,employ
R5983 T8849 T8850 amod different,mechanisms
R5984 T8850 T8848 dobj mechanisms,employ
R5985 T8851 T8850 punct ",",mechanisms
R5986 T8852 T8850 prep including,mechanisms
R5987 T8853 T8854 det the,expression
R5988 T8854 T8852 pobj expression,including
R5989 T8855 T8854 prep of,expression
R5990 T8856 T8857 amod inhibitory,proteins
R5991 T8857 T8855 pobj proteins,of
R5992 T8858 T8861 nsubj that,signalling
R5993 T8859 T8861 dep downregulate,signalling
R5994 T8860 T8861 amod NF-κB,signalling
R5995 T8861 T8854 relcl signalling,expression
R5996 T8862 T8864 nmod [,]
R5997 T8863 T8864 nummod 32,]
R5998 T8864 T8861 dobj ],signalling
R5999 T8865 T8848 punct .,employ
R6000 T8866 T8868 advmod Below,give
R6001 T8867 T8868 nsubj we,give
R6002 T8868 T8868 ROOT give,give
R6003 T8869 T8870 det an,overview
R6004 T8870 T8868 dobj overview,give
R6005 T8871 T8870 prep of,overview
R6006 T8872 T8873 det a,number
R6007 T8873 T8871 pobj number,of
R6008 T8874 T8873 prep of,number
R6009 T8875 T8874 pobj proteins,of
R6010 T8876 T8878 nsubjpass that,involved
R6011 T8877 T8878 auxpass are,involved
R6012 T8878 T8875 relcl involved,proteins
R6013 T8879 T8878 prep in,involved
R6014 T8880 T8881 det the,dampening
R6015 T8881 T8879 pobj dampening,in
R6016 T8882 T8881 cc or,dampening
R6017 T8883 T8881 conj termination,dampening
R6018 T8884 T8883 prep of,termination
R6019 T8885 T8887 det the,response
R6020 T8886 T8887 compound NF-κB,response
R6021 T8887 T8884 pobj response,of
R6022 T8888 T8870 punct ",",overview
R6023 T8889 T8900 nsubj some,acting
R6024 T8890 T8889 prep of,some
R6025 T8891 T8890 pobj them,of
R6026 T8892 T8889 prep under,some
R6027 T8893 T8894 det the,control
R6028 T8894 T8892 pobj control,under
R6029 T8895 T8894 prep of,control
R6030 T8896 T8895 pobj NF-κB,of
R6031 T8897 T8896 dobj itself,NF-κB
R6032 T8898 T8896 cc and,NF-κB
R6033 T8899 T8900 advmod thus,acting
R6034 T8900 T8870 acl acting,overview
R6035 T8901 T8900 prep in,acting
R6036 T8902 T8905 det a,loop
R6037 T8903 T8905 amod negative,loop
R6038 T8904 T8905 compound feedback,loop
R6039 T8905 T8901 pobj loop,in
R6040 T8906 T8868 punct .,give
R6041 T8907 T8911 prep In,discuss
R6042 T8908 T8907 pobj addition,In
R6043 T8909 T8911 punct ",",discuss
R6044 T8910 T8911 nsubj we,discuss
R6045 T8911 T8911 ROOT discuss,discuss
R6046 T8912 T8914 det the,role
R6047 T8913 T8914 amod potential,role
R6048 T8914 T8911 dobj role,discuss
R6049 T8915 T8914 prep of,role
R6050 T8916 T8919 det these,factors
R6051 T8917 T8919 amod NF-κB,factors
R6052 T8918 T8919 compound inhibitory,factors
R6053 T8919 T8915 pobj factors,of
R6054 T8920 T8914 prep in,role
R6055 T8921 T8922 det the,immunopathology
R6056 T8922 T8920 pobj immunopathology,in
R6057 T8923 T8922 prep of,immunopathology
R6058 T8924 T8923 pobj RA,of
R6059 T8925 T8911 punct .,discuss
R6060 T8926 T8928 amod Several,proteins
R6061 T8927 T8928 amod other,proteins
R6062 T8928 T8950 nsubjpass proteins,described
R6063 T8929 T8928 acl involved,proteins
R6064 T8930 T8929 prep in,involved
R6065 T8931 T8933 det the,regulation
R6066 T8932 T8933 amod negative,regulation
R6067 T8933 T8930 pobj regulation,in
R6068 T8934 T8933 prep of,regulation
R6069 T8935 T8937 amod NF-κB-dependent,responses
R6070 T8936 T8937 amod inflammatory,responses
R6071 T8937 T8934 pobj responses,of
R6072 T8938 T8937 punct ",",responses
R6073 T8939 T8940 amod such,as
R6074 T8940 T8937 prep as,responses
R6075 T8941 T8940 pobj MyD88s,as
R6076 T8942 T8941 punct ",",MyD88s
R6077 T8943 T8941 conj IRAK-M,MyD88s
R6078 T8944 T8943 punct ",",IRAK-M
R6079 T8945 T8943 cc and,IRAK-M
R6080 T8946 T8943 conj TOLLIP,IRAK-M
R6081 T8947 T8950 punct ",",described
R6082 T8948 T8950 aux have,described
R6083 T8949 T8950 auxpass been,described
R6084 T8950 T8950 ROOT described,described
R6085 T8951 T8950 punct (,described
R6086 T8952 T8950 advcl reviewed,described
R6087 T8953 T8952 prep in,reviewed
R6088 T8954 T8953 pobj [,in
R6089 T8955 T8956 nummod 33,]
R6090 T8956 T8954 appos ],[
R6091 T8957 T8954 punct ),[
R6092 T8958 T8950 punct .,described
R6093 T8959 T8960 det These,proteins
R6094 T8960 T8963 nsubjpass proteins,discussed
R6095 T8961 T8963 auxpass are,discussed
R6096 T8962 T8963 neg not,discussed
R6097 T8963 T8963 ROOT discussed,discussed
R6098 T8964 T8963 advmod here,discussed
R6099 T8965 T8963 punct ",",discussed
R6100 T8966 T8963 prep since,discussed
R6101 T8967 T8968 det a,link
R6102 T8968 T8966 pobj link,since
R6103 T8969 T8968 prep with,link
R6104 T8970 T8971 compound RA,pathology
R6105 T8971 T8969 pobj pathology,with
R6106 T8972 T8978 advcl has,is
R6107 T8973 T8976 neg not,"reported. Although"
R6108 T8974 T8976 advmod yet,"reported. Although"
R6109 T8975 T8976 auxpass been,"reported. Although"
R6110 T8976 T8977 compound "reported. Although",IKK1
R6111 T8977 T8978 nsubj IKK1,is
R6112 T8978 T8991 advcl is,mentioned
R6113 T8979 T8981 det a,component
R6114 T8980 T8981 amod critical,component
R6115 T8981 T8978 attr component,is
R6116 T8982 T8981 prep of,component
R6117 T8983 T8986 det the,pathway
R6118 T8984 T8986 amod non-canonical,pathway
R6119 T8985 T8986 compound NF-κB,pathway
R6120 T8986 T8982 pobj pathway,of
R6121 T8987 T8991 punct ",",mentioned
R6122 T8988 T8991 nsubjpass it,mentioned
R6123 T8989 T8991 aux should,mentioned
R6124 T8990 T8991 auxpass be,mentioned
R6125 T8991 T8963 advcl mentioned,discussed
R6126 T8992 T8996 mark that,plays
R6127 T8993 T8994 det this,kinase
R6128 T8994 T8996 nsubj kinase,plays
R6129 T8995 T8996 advmod also,plays
R6130 T8996 T8991 ccomp plays,mentioned
R6131 T8997 T8999 det a,role
R6132 T8998 T8999 amod prominent,role
R6133 T8999 T8996 dobj role,plays
R6134 T9000 T8999 prep in,role
R6135 T9001 T9003 det the,regulation
R6136 T9002 T9003 amod negative,regulation
R6137 T9003 T9000 pobj regulation,in
R6138 T9004 T9003 prep of,regulation
R6139 T9005 T9006 preconj both,canonical
R6140 T9006 T9010 amod canonical,pathways
R6141 T9007 T9006 cc and,canonical
R6142 T9008 T9006 conj noncanonical,canonical
R6143 T9009 T9010 compound NF-κB,pathways
R6144 T9010 T9004 pobj pathways,of
R6145 T9011 T8963 punct .,discussed
R6146 T9012 T9023 nsubj Macrophages,increased
R6147 T9013 T9012 prep from,Macrophages
R6148 T9014 T9015 amod IKK1-deficient,mice
R6149 T9015 T9013 pobj mice,from
R6150 T9016 T9015 cc or,mice
R6151 T9017 T9018 compound knockin,mice
R6152 T9018 T9015 conj mice,mice
R6153 T9019 T9012 acl expressing,Macrophages
R6154 T9020 T9022 amod inactive,show
R6155 T9021 T9022 compound IKK1,show
R6156 T9022 T9019 dobj show,expressing
R6157 T9023 T9023 ROOT increased,increased
R6158 T9024 T9023 dobj production,increased
R6159 T9025 T9024 prep of,production
R6160 T9026 T9027 amod proinflammatory,cytokines
R6161 T9027 T9025 pobj cytokines,of
R6162 T9028 T9023 prep as,increased
R6163 T9029 T9030 det a,result
R6164 T9030 T9028 pobj result,as
R6165 T9031 T9030 prep of,result
R6166 T9032 T9034 amod enhanced,activation
R6167 T9033 T9034 compound IKK2,activation
R6168 T9034 T9031 pobj activation,of
R6169 T9035 T9034 cc and,activation
R6170 T9036 T9037 compound IκBα,degradation
R6171 T9037 T9034 conj degradation,activation
R6172 T9038 T9040 nmod [,]
R6173 T9039 T9040 nummod 34,]
R6174 T9040 T9037 appos ],degradation
R6175 T9041 T9023 punct .,increased
R6176 T9042 T9046 nsubjpass IKK1,shown
R6177 T9043 T9046 aux has,shown
R6178 T9044 T9046 advmod also,shown
R6179 T9045 T9046 auxpass been,shown
R6180 T9046 T9046 ROOT shown,shown
R6181 T9047 T9048 aux to,inhibit
R6182 T9048 T9046 advcl inhibit,shown
R6183 T9049 T9050 amod nuclear,NF-κB
R6184 T9050 T9048 dobj NF-κB,inhibit
R6185 T9051 T9048 cc and,inhibit
R6186 T9052 T9053 aux to,downregulate
R6187 T9053 T9048 conj downregulate,inhibit
R6188 T9054 T9055 compound proinflammatory,signalling
R6189 T9055 T9053 dobj signalling,downregulate
R6190 T9056 T9053 prep by,downregulate
R6191 T9057 T9056 pcomp phosphorylating,by
R6192 T9058 T9059 compound STAT1,[
R6193 T9059 T9057 dobj [,phosphorylating
R6194 T9060 T9061 nummod 35,]
R6195 T9061 T9059 appos ],[
R6196 T9062 T9046 punct .,shown
R6197 T9063 T9069 advmod Interestingly,demonstrated
R6198 T9064 T9069 punct ",",demonstrated
R6199 T9065 T9067 det a,study
R6200 T9066 T9067 amod recent,study
R6201 T9067 T9069 nsubj study,demonstrated
R6202 T9068 T9069 aux has,demonstrated
R6203 T9069 T9069 ROOT demonstrated,demonstrated
R6204 T9070 T9069 dobj that,demonstrated
R6205 T9071 T9072 nummod IKK1,phosphorylates
R6206 T9072 T9070 nsubj phosphorylates,that
R6207 T9073 T9072 appos NIK,phosphorylates
R6208 T9074 T9073 prep in,NIK
R6209 T9075 T9077 amod negative,regulation
R6210 T9076 T9077 compound feedback,regulation
R6211 T9077 T9074 pobj regulation,in
R6212 T9078 T9077 prep of,regulation
R6213 T9079 T9082 det the,pathway
R6214 T9080 T9082 amod noncanonical,pathway
R6215 T9081 T9082 compound NF-κB,pathway
R6216 T9082 T9078 pobj pathway,of
R6217 T9083 T9085 nmod [,]
R6218 T9084 T9085 nummod 36,]
R6219 T9085 T9082 appos ],pathway
R6220 T9086 T9072 punct ",",phosphorylates
R6221 T9087 T9072 acl supporting,phosphorylates
R6222 T9088 T9089 det the,idea
R6223 T9089 T9087 dobj idea,supporting
R6224 T9090 T9092 mark that,plays
R6225 T9091 T9092 nsubj IKK1,plays
R6226 T9092 T9089 acl plays,idea
R6227 T9093 T9094 amod important,roles
R6228 T9094 T9092 dobj roles,plays
R6229 T9095 T9092 prep in,plays
R6230 T9096 T9095 pcomp terminating,in
R6231 T9097 T9098 preconj both,canonical
R6232 T9098 T9102 amod canonical,pathways
R6233 T9099 T9098 cc and,canonical
R6234 T9100 T9098 conj noncanonical,canonical
R6235 T9101 T9102 compound NF-κB,pathways
R6236 T9102 T9096 dobj pathways,terminating
R6237 T9103 T9102 prep with,pathways
R6238 T9104 T9105 amod possible,implications
R6239 T9105 T9103 pobj implications,with
R6240 T9106 T9105 prep for,implications
R6241 T9107 T9109 amod chronic,diseases
R6242 T9108 T9109 amod inflammatory,diseases
R6243 T9109 T9106 pobj diseases,for
R6244 T9110 T9109 prep like,diseases
R6245 T9111 T9110 pobj RA,like
R6246 T9112 T9069 punct .,demonstrated
R642 T832 T833 amod Rheumatoid,arthritis
R643 T833 T837 nsubj arthritis,is
R644 T834 T833 punct (,arthritis
R645 T835 T833 appos RA,arthritis
R646 T836 T833 punct ),arthritis
R647 T837 T837 ROOT is,is
R648 T838 T842 det the,arthritis
R649 T839 T840 advmod most,common
R650 T840 T842 amod common,arthritis
R651 T841 T842 amod inflammatory,arthritis
R652 T842 T837 attr arthritis,is
R653 T843 T837 punct ",",is
R654 T844 T837 advcl affecting,is
R655 T845 T847 quantmod up,1
R656 T846 T847 quantmod to,1
R657 T847 T848 nummod 1,%
R658 T848 T844 dobj %,affecting
R659 T849 T848 prep of,%
R660 T850 T852 det the,population
R661 T851 T852 compound adult,population
R662 T852 T849 pobj population,of
R663 T853 T837 punct .,is
R664 T854 T856 nsubjpass RA,characterised
R665 T855 T856 auxpass is,characterised
R666 T856 T856 ROOT characterised,characterised
R667 T857 T856 agent by,characterised
R668 T858 T860 det a,polyarthritis
R669 T859 T860 amod symmetrical,polyarthritis
R670 T860 T857 pobj polyarthritis,by
R671 T861 T868 prep in,associated
R672 T862 T861 pobj which,in
R673 T863 T864 amod chronic,inflammation
R674 T864 T868 nsubjpass inflammation,associated
R675 T865 T864 prep of,inflammation
R676 T866 T865 pobj joints,of
R677 T867 T868 auxpass is,associated
R678 T868 T860 relcl associated,polyarthritis
R679 T869 T868 prep with,associated
R680 T870 T872 det a,destruction
R681 T871 T872 amod progressive,destruction
R682 T872 T869 pobj destruction,with
R683 T873 T872 prep of,destruction
R684 T874 T873 pobj cartilage,of
R685 T875 T874 cc and,cartilage
R686 T876 T874 conj bone,cartilage
R687 T877 T872 punct ",",destruction
R688 T878 T872 acl leading,destruction
R689 T879 T878 prep to,leading
R690 T880 T881 amod functional,decline
R691 T881 T879 pobj decline,to
R692 T882 T881 cc and,decline
R693 T883 T881 conj disability,decline
R694 T884 T856 punct .,characterised
R695 T885 T899 nsubj Infiltration,drives
R696 T886 T885 prep of,Infiltration
R697 T887 T886 pobj cells,of
R698 T888 T887 prep of,cells
R699 T889 T894 det the,system
R700 T890 T894 amod innate,system
R701 T891 T890 cc and,innate
R702 T892 T890 conj adaptive,innate
R703 T893 T894 amod immune,system
R704 T894 T888 pobj system,of
R705 T895 T885 prep into,Infiltration
R706 T896 T898 det the,space
R707 T897 T898 amod joint,space
R708 T898 T899 nsubj space,drives
R709 T899 T899 ROOT drives,drives
R710 T900 T902 det the,production
R711 T901 T902 amod local,production
R712 T902 T899 dobj production,drives
R713 T903 T902 prep of,production
R714 T904 T906 amod proinflammatory,type
R715 T905 T906 compound T-helper,type
R716 T906 T903 pobj type,of
R717 T907 T906 nummod 1,type
R718 T908 T906 cc and,type
R719 T909 T910 compound T-helper,type
R720 T910 T906 conj type,type
R721 T911 T912 nummod 17,cytokines
R722 T912 T906 appos cytokines,type
R723 T913 T912 punct ",",cytokines
R7232 T10859 T10861 nummod A20,A20
R7233 T10860 T10861 compound protein,A20
R7234 T10861 T10868 nsubj A20,is
R7235 T10862 T10864 punct (,known
R7236 T10863 T10864 advmod also,known
R7237 T10864 T10861 acl known,A20
R7238 T10865 T10864 prep as,known
R7239 T10866 T10865 pobj TNFAIP3,as
R724 T914 T912 conj chemokines,cytokines
R7240 T10867 T10861 punct ),A20
R7241 T10868 T10868 ROOT is,is
R7242 T10869 T10871 det a,protein
R7243 T10870 T10871 amod ubiquitin-editing,protein
R7244 T10871 T10868 attr protein,is
R7245 T10872 T10874 nsubj that,regulates
R7246 T10873 T10874 advmod negatively,regulates
R7247 T10874 T10871 relcl regulates,protein
R7248 T10875 T10877 amod NF-κB-dependent,expression
R7249 T10876 T10877 compound gene,expression
R725 T915 T914 punct ",",chemokines
R7250 T10877 T10874 dobj expression,regulates
R7251 T10878 T10874 prep in,regulates
R7252 T10879 T10878 pobj response,in
R7253 T10880 T10879 prep to,response
R7254 T10881 T10883 amod different,stimuli
R7255 T10882 T10883 amod immune-activating,stimuli
R7256 T10883 T10880 pobj stimuli,to
R7257 T10884 T10883 punct ",",stimuli
R7258 T10885 T10883 prep including,stimuli
R7259 T10886 T10885 pobj TNF,including
R726 T916 T914 cc and,chemokines
R7260 T10887 T10886 punct ",",TNF
R7261 T10888 T10886 conj IL-1,TNF
R7262 T10889 T10888 cc and,IL-1
R7263 T10890 T10888 conj antigens,IL-1
R7264 T10891 T10883 punct ",",stimuli
R7265 T10892 T10883 cc and,stimuli
R7266 T10893 T10894 det the,triggering
R7267 T10894 T10883 conj triggering,stimuli
R7268 T10895 T10894 prep of,triggering
R7269 T10896 T10895 pobj TLRs,of
R727 T917 T918 compound matrix,metalloproteinases
R7270 T10897 T10896 cc and,TLRs
R7271 T10898 T10903 det the,receptor
R7272 T10899 T10901 nmod nucleotide-binding,domain-containing
R7273 T10900 T10901 compound oligomerisation,domain-containing
R7274 T10901 T10903 nmod domain-containing,receptor
R7275 T10902 T10903 nummod 2,receptor
R7276 T10903 T10896 conj receptor,TLRs
R7277 T10904 T10905 punct (,reviewed
R7278 T10905 T10883 acl reviewed,stimuli
R7279 T10906 T10905 prep in,reviewed
R728 T918 T914 conj metalloproteinases,chemokines
R7280 T10907 T10906 pobj [,in
R7281 T10908 T10909 nummod 37,]
R7282 T10909 T10907 appos ],[
R7283 T10910 T10907 punct ),[
R7284 T10911 T10868 punct .,is
R7285 T10912 T10914 nsubjpass A20,believed
R7286 T10913 T10914 auxpass is,believed
R7287 T10914 T10914 ROOT believed,believed
R7288 T10915 T10916 aux to,inhibit
R7289 T10916 T10914 xcomp inhibit,believed
R729 T919 T899 prep by,drives
R7290 T10917 T10918 amod NF-κB,function
R7291 T10918 T10916 dobj function,inhibit
R7292 T10919 T10916 prep by,inhibit
R7293 T10920 T10919 pcomp deubiquitinating,by
R7294 T10921 T10924 amod specific,molecules
R7295 T10922 T10923 npadvmod NF-κB,signalling
R7296 T10923 T10924 amod signalling,molecules
R7297 T10924 T10920 dobj molecules,deubiquitinating
R7298 T10925 T10924 punct ",",molecules
R7299 T10926 T10927 amod such,as
R730 T920 T919 pcomp infiltrating,by
R7300 T10927 T10924 prep as,molecules
R7301 T10928 T10927 pobj RIP1,as
R7302 T10929 T10928 punct ",",RIP1
R7303 T10930 T10928 conj RIP2,RIP1
R7304 T10931 T10930 punct ",",RIP2
R7305 T10932 T10930 conj TRAF6,RIP2
R7306 T10933 T10932 cc and,TRAF6
R7307 T10934 T10932 conj MALT1,TRAF6
R7308 T10935 T10928 punct ",",RIP1
R7309 T10936 T10937 nsubj which,disrupts
R731 T921 T920 dobj monocytes,infiltrating
R7310 T10937 T10928 relcl disrupts,RIP1
R7311 T10938 T10940 amod specific,interactions
R7312 T10939 T10940 amod protein-protein,interactions
R7313 T10940 T10937 dobj interactions,disrupts
R7314 T10941 T10943 nmod [,]
R7315 T10942 T10943 nummod 38-41,]
R7316 T10943 T10940 nmod ],interactions
R7317 T10944 T10945 punct (,Figure
R7318 T10945 T10943 appos Figure,]
R7319 T10946 T10945 nummod 1,Figure
R732 T922 T921 cc and,monocytes
R7320 T10947 T10943 punct ),]
R7321 T10948 T10914 punct .,believed
R7322 T10949 T10977 advmod Recently,described
R7323 T10950 T10977 punct ",",described
R7324 T10951 T10952 det the,disruption
R7325 T10952 T10977 nsubjpass disruption,described
R7326 T10953 T10952 prep of,disruption
R7327 T10954 T10953 pobj interactions,of
R7328 T10955 T10952 prep between,disruption
R7329 T10956 T10959 nummod E2,enzymes
R733 T923 T924 amod synovial,cells
R7330 T10957 T10959 nmod ubiquitin,enzymes
R7331 T10958 T10959 amod conjugating,enzymes
R7332 T10959 T10955 pobj enzymes,between
R7333 T10960 T10959 punct (,enzymes
R7334 T10961 T10977 nsubjpass Ubc13,described
R7335 T10962 T10961 cc and,Ubc13
R7336 T10963 T10961 conj Ubc5hc,Ubc13
R7337 T10964 T10963 punct ),Ubc5hc
R7338 T10965 T10961 cc and,Ubc13
R7339 T10966 T10968 nummod E3,ligases
R734 T924 T921 conj cells,monocytes
R7340 T10967 T10968 compound ubiquitin,ligases
R7341 T10968 T10961 conj ligases,Ubc13
R7342 T10969 T10968 punct (,ligases
R7343 T10970 T10968 appos TRAF6,ligases
R7344 T10971 T10970 punct ",",TRAF6
R7345 T10972 T10970 conj TRAF2,TRAF6
R7346 T10973 T10972 cc and,TRAF2
R7347 T10974 T10972 conj cIAP1/2,TRAF2
R7348 T10975 T10968 punct ),ligases
R7349 T10976 T10977 auxpass were,described
R735 T925 T899 punct .,drives
R7350 T10977 T10977 ROOT described,described
R7351 T10978 T10977 prep as,described
R7352 T10979 T10981 det another,mechanism
R7353 T10980 T10981 amod important,mechanism
R7354 T10981 T10978 pobj mechanism,as
R7355 T10982 T10981 acl used,mechanism
R7356 T10983 T10982 agent by,used
R7357 T10984 T10983 pobj A20,by
R7358 T10985 T10981 prep to,mechanism
R7359 T10986 T10985 pobj downregulate,to
R736 T926 T930 nsubj Proliferation,leads
R7360 T10987 T10988 npadvmod NF-κB,signalling
R7361 T10988 T10986 amod signalling,downregulate
R7362 T10989 T10991 nmod [,]
R7363 T10990 T10991 nummod 42,]
R7364 T10991 T10988 dobj ],signalling
R7365 T10992 T10977 punct .,described
R7366 T10993 T10994 det The,association
R7367 T10994 T11000 nsubj association,requires
R7368 T10995 T10994 prep of,association
R7369 T10996 T10995 pobj A20,of
R737 T927 T926 prep of,Proliferation
R7370 T10997 T10994 prep with,association
R7371 T10998 T10999 poss its,targets
R7372 T10999 T10997 pobj targets,with
R7373 T11000 T11000 ROOT requires,requires
R7374 T11001 T11004 amod specific,proteins
R7375 T11002 T11004 amod ubiquitin-binding,proteins
R7376 T11003 T11004 compound adaptor,proteins
R7377 T11004 T11000 dobj proteins,requires
R7378 T11005 T11004 punct ",",proteins
R7379 T11006 T11004 prep including,proteins
R738 T928 T929 amod synovial,fibroblasts
R7380 T11007 T11008 amod A20-binding,inhibitor
R7381 T11008 T11006 pobj inhibitor,including
R7382 T11009 T11008 prep of,inhibitor
R7383 T11010 T11009 pobj NF-κB,of
R7384 T11011 T11010 punct (,NF-κB
R7385 T11012 T11010 appos ABIN,NF-κB
R7386 T11013 T11010 punct ),NF-κB
R7387 T11014 T11010 nummod 1,NF-κB
R7388 T11015 T11008 cc and,inhibitor
R7389 T11016 T11017 amod Tax1-binding,protein
R739 T929 T927 pobj fibroblasts,of
R7390 T11017 T11008 conj protein,inhibitor
R7391 T11018 T11019 nummod 1,[
R7392 T11019 T11021 compound [,]
R7393 T11020 T11021 compound 43-46,]
R7394 T11021 T11004 appos ],proteins
R7395 T11022 T11000 punct .,requires
R7396 T11023 T11033 advmod Next,is
R7397 T11024 T11023 prep to,Next
R7398 T11025 T11026 poss its,role
R7399 T11026 T11024 pobj role,to
R740 T930 T930 ROOT leads,leads
R7400 T11027 T11026 prep in,role
R7401 T11028 T11027 pcomp suppressing,in
R7402 T11029 T11030 amod NF-κB,activation
R7403 T11030 T11028 dobj activation,suppressing
R7404 T11031 T11033 punct ",",is
R7405 T11032 T11033 nsubj A20,is
R7406 T11033 T11033 ROOT is,is
R7407 T11034 T11033 advmod also,is
R7408 T11035 T11037 det a,inhibitor
R7409 T11036 T11037 amod strong,inhibitor
R741 T931 T930 prep to,leads
R7410 T11037 T11033 attr inhibitor,is
R7411 T11038 T11037 prep of,inhibitor
R7412 T11039 T11038 pobj apoptosis,of
R7413 T11040 T11037 punct ",",inhibitor
R7414 T11041 T11042 advmod at,least
R7415 T11042 T11043 advmod least,in
R7416 T11043 T11037 prep in,inhibitor
R7417 T11044 T11046 det some,types
R7418 T11045 T11046 compound cell,types
R7419 T11046 T11043 pobj types,in
R742 T932 T933 det the,formation
R7420 T11047 T11033 punct .,is
R7421 T11048 T11049 det The,mechanisms
R7422 T11049 T11059 nsubj mechanisms,are
R7423 T11050 T11053 prep by,regulates
R7424 T11051 T11050 pobj which,by
R7425 T11052 T11053 nsubj A20,regulates
R7426 T11053 T11049 relcl regulates,mechanisms
R7427 T11054 T11055 amod apoptotic,signalling
R7428 T11055 T11053 dobj signalling,regulates
R7429 T11056 T11053 punct ",",regulates
R743 T933 T931 pobj formation,to
R7430 T11057 T11059 advmod however,are
R7431 T11058 T11059 punct ",",are
R7432 T11059 T11059 ROOT are,are
R7433 T11060 T11059 advmod still,are
R7434 T11061 T11059 acomp elusive,are
R7435 T11062 T11059 punct .,are
R7436 T11063 T11064 amod A20-deficient,mice
R7437 T11064 T11066 nsubj mice,develop
R7438 T11065 T11066 advmod spontaneously,develop
R7439 T11066 T11066 ROOT develop,develop
R744 T934 T933 prep of,formation
R7440 T11067 T11068 amod multiorgan,inflammation
R7441 T11068 T11066 dobj inflammation,develop
R7442 T11069 T11068 cc and,inflammation
R7443 T11070 T11068 conj cachexia,inflammation
R7444 T11071 T11070 cc and,cachexia
R7445 T11072 T11066 conj die,develop
R7446 T11073 T11072 prep within,die
R7447 T11074 T11075 nummod 2,weeks
R7448 T11075 T11073 pobj weeks,within
R7449 T11076 T11075 prep of,weeks
R745 T935 T936 amod pannus,tissue
R7450 T11077 T11076 pobj birth,of
R7451 T11078 T11072 punct ",",die
R7452 T11079 T11072 advcl illustrating,die
R7453 T11080 T11083 det the,function
R7454 T11081 T11083 amod potent,function
R7455 T11082 T11083 amod anti-inflammatory,function
R7456 T11083 T11079 dobj function,illustrating
R7457 T11084 T11083 prep of,function
R7458 T11085 T11086 det this,molecule
R7459 T11086 T11084 pobj molecule,of
R746 T936 T934 pobj tissue,of
R7460 T11087 T11089 nmod [,]
R7461 T11088 T11089 nummod 46,]
R7462 T11089 T11083 appos ],function
R7463 T11090 T11066 punct .,develop
R7464 T11091 T11092 amod A20-deficient,cells
R7465 T11092 T11093 nsubj cells,are
R7466 T11093 T11093 ROOT are,are
R7467 T11094 T11093 advmod also,are
R7468 T11095 T11096 advmod more,susceptible
R7469 T11096 T11093 acomp susceptible,are
R747 T937 T936 punct ",",tissue
R7470 T11097 T11096 prep to,susceptible
R7471 T11098 T11099 amod TNF-mediated,apoptosis
R7472 T11099 T11097 pobj apoptosis,to
R7473 T11100 T11093 punct ",",are
R7474 T11101 T11093 advcl confirming,are
R7475 T11102 T11103 poss its,role
R7476 T11103 T11101 dobj role,confirming
R7477 T11104 T11103 prep as,role
R7478 T11105 T11107 det an,protein
R7479 T11106 T11107 amod antiapoptotic,protein
R748 T938 T939 nsubj which,invades
R7480 T11107 T11104 pobj protein,as
R7481 T11108 T11093 punct .,are
R7482 T11109 T11111 nsubj We,showed
R7483 T11110 T11111 advmod recently,showed
R7484 T11111 T11111 ROOT showed,showed
R7485 T11112 T11121 mark that,exhibit
R7486 T11113 T11121 nsubj mice,exhibit
R7487 T11114 T11115 advmod specifically,lacking
R7488 T11115 T11113 acl lacking,mice
R7489 T11116 T11115 dobj A20,lacking
R749 T939 T936 relcl invades,tissue
R7490 T11117 T11115 prep in,lacking
R7491 T11118 T11120 amod intestinal,cells
R7492 T11119 T11120 amod epithelial,cells
R7493 T11120 T11117 pobj cells,in
R7494 T11121 T11111 ccomp exhibit,showed
R7495 T11122 T11123 amod increased,susceptibility
R7496 T11123 T11121 dobj susceptibility,exhibit
R7497 T11124 T11121 prep to,exhibit
R7498 T11125 T11126 amod experimental,colitis
R7499 T11126 T11124 pobj colitis,to
R750 T940 T939 cc and,invades
R7500 T11127 T11126 amod due,colitis
R7501 T11128 T11127 pcomp to,due
R7502 T11129 T11130 det the,hypersensitivity
R7503 T11130 T11128 pobj hypersensitivity,to
R7504 T11131 T11130 prep of,hypersensitivity
R7505 T11132 T11135 poss their,cells
R7506 T11133 T11135 amod intestinal,cells
R7507 T11134 T11135 amod epithelial,cells
R7508 T11135 T11131 pobj cells,of
R7509 T11136 T11127 pcomp to,due
R751 T941 T939 conj degrades,invades
R7510 T11137 T11138 amod TNF-induced,apoptosis
R7511 T11138 T11136 pobj apoptosis,to
R7512 T11139 T11121 punct ",",exhibit
R7513 T11140 T11121 advcl confirming,exhibit
R7514 T11141 T11140 dobj A20,confirming
R7515 T11142 T11140 prep as,confirming
R7516 T11143 T11146 det a,protein
R7517 T11144 T11146 amod major,protein
R7518 T11145 T11146 amod antiapoptotic,protein
R7519 T11146 T11142 pobj protein,as
R752 T942 T943 amod articular,cartilage
R7520 T11147 T11146 prep in,protein
R7521 T11148 T11151 det the,[
R7522 T11149 T11150 amod intestinal,epithelium
R7523 T11150 T11151 compound epithelium,[
R7524 T11151 T11147 pobj [,in
R7525 T11152 T11153 nummod 47,]
R7526 T11153 T11151 appos ],[
R7527 T11154 T11111 punct .,showed
R7528 T11155 T11157 nummod Two,studies
R7529 T11156 T11157 amod independent,studies
R753 T943 T941 dobj cartilage,degrades
R7530 T11157 T11158 nsubj studies,showed
R7531 T11158 T11158 ROOT showed,showed
R7532 T11159 T11166 mark that,develop
R7533 T11160 T11166 nsubj mice,develop
R7534 T11161 T11160 acl lacking,mice
R7535 T11162 T11161 dobj A20,lacking
R7536 T11163 T11161 prep in,lacking
R7537 T11164 T11165 compound B,cells
R7538 T11165 T11163 pobj cells,in
R7539 T11166 T11158 ccomp develop,showed
R754 T944 T943 cc and,cartilage
R7540 T11167 T11166 dobj autoimmunity,develop
R7541 T11168 T11166 prep due,develop
R7542 T11169 T11168 pcomp to,due
R7543 T11170 T11172 amod hyperactive,responses
R7544 T11171 T11172 compound NF-κB,responses
R7545 T11172 T11169 pobj responses,to
R7546 T11173 T11172 prep in,responses
R7547 T11174 T11175 compound B,cells
R7548 T11175 T11173 pobj cells,in
R7549 T11176 T11175 acl leading,cells
R755 T945 T946 amod subchondral,bone
R7550 T11177 T11176 prep to,leading
R7551 T11178 T11180 amod unrestricted,survival
R7552 T11179 T11180 compound B-cell,survival
R7553 T11180 T11177 pobj survival,to
R7554 T11181 T11183 nmod [,]
R7555 T11182 T11183 nummod "48,49",]
R7556 T11183 T11168 pobj ],due
R7557 T11184 T11158 punct .,showed
R7558 T11185 T11186 nummod A20,expression
R7559 T11186 T11189 nsubjpass expression,observed
R756 T946 T943 conj bone,cartilage
R7560 T11187 T11189 aux has,observed
R7561 T11188 T11189 auxpass been,observed
R7562 T11189 T11189 ROOT observed,observed
R7563 T11190 T11189 prep in,observed
R7564 T11191 T11193 amod several,types
R7565 T11192 T11193 compound cell,types
R7566 T11193 T11190 pobj types,in
R7567 T11194 T11195 nsubj that,play
R7568 T11195 T11193 relcl play,types
R7569 T11196 T11197 amod important,roles
R757 T947 T930 punct .,leads
R7570 T11197 T11195 dobj roles,play
R7571 T11198 T11195 prep in,play
R7572 T11199 T11200 det the,pathophysiology
R7573 T11200 T11198 pobj pathophysiology,in
R7574 T11201 T11200 prep of,pathophysiology
R7575 T11202 T11201 pobj RA,of
R7576 T11203 T11195 punct ",",play
R7577 T11204 T11205 amod such,as
R7578 T11205 T11193 prep as,types
R7579 T11206 T11205 pobj fibroblasts,as
R758 T948 T949 det The,aetiology
R7580 T11207 T11206 punct ",",fibroblasts
R7581 T11208 T11206 conj synoviocytes,fibroblasts
R7582 T11209 T11208 cc and,synoviocytes
R7583 T11210 T11208 conj lymphocytes,synoviocytes
R7584 T11211 T11189 punct .,observed
R7585 T11212 T11216 advmod Interestingly,is
R7586 T11213 T11216 punct ",",is
R7587 T11214 T11215 compound A20,expression
R7588 T11215 T11216 nsubj expression,is
R7589 T11216 T11216 ROOT is,is
R759 T949 T952 nsubj aetiology,is
R7590 T11217 T11218 nsubjpass itself,regulated
R7591 T11218 T11216 ccomp regulated,is
R7592 T11219 T11218 agent by,regulated
R7593 T11220 T11221 compound NF-κB,[
R7594 T11221 T11223 nmod [,]
R7595 T11222 T11223 nummod 50,]
R7596 T11223 T11219 pobj ],by
R7597 T11224 T11216 punct ",",is
R7598 T11225 T11216 advcl implicating,is
R7599 T11226 T11225 dobj A20,implicating
R760 T950 T949 prep of,aetiology
R7600 T11227 T11225 prep in,implicating
R7601 T11228 T11231 det the,regulation
R7602 T11229 T11231 amod negative,regulation
R7603 T11230 T11231 compound feedback,regulation
R7604 T11231 T11227 pobj regulation,in
R7605 T11232 T11231 prep of,regulation
R7606 T11233 T11234 amod NF-κB,signalling
R7607 T11234 T11232 pobj signalling,of
R7608 T11235 T11216 punct .,is
R7609 T11236 T11245 advmod Recently,shown
R761 T951 T950 pobj RA,of
R7610 T11237 T11245 punct ",",shown
R7611 T11238 T11239 amod intra-articular,injection
R7612 T11239 T11245 nsubjpass injection,shown
R7613 T11240 T11239 prep of,injection
R7614 T11241 T11243 det an,adenovirus
R7615 T11242 T11243 amod A20-expressing,adenovirus
R7616 T11243 T11240 pobj adenovirus,of
R7617 T11244 T11245 auxpass was,shown
R7618 T11245 T11245 ROOT shown,shown
R7619 T11246 T11247 aux to,reduce
R762 T952 T955 auxpass is,understood
R7620 T11247 T11245 xcomp reduce,shown
R7621 T11248 T11249 det the,severity
R7622 T11249 T11247 dobj severity,reduce
R7623 T11250 T11249 prep of,severity
R7624 T11251 T11252 amod synovial,inflammation
R7625 T11252 T11250 pobj inflammation,of
R7626 T11253 T11252 cc and,inflammation
R7627 T11254 T11255 amod joint,destruction
R7628 T11255 T11252 conj destruction,inflammation
R7629 T11256 T11247 prep in,reduce
R763 T953 T955 advmod still,understood
R7630 T11257 T11259 det a,model
R7631 T11258 T11259 compound mouse,model
R7632 T11259 T11256 pobj model,in
R7633 T11260 T11259 prep of,model
R7634 T11261 T11262 amod collagen-induced,arthritis
R7635 T11262 T11260 pobj arthritis,of
R7636 T11263 T11247 punct ",",reduce
R7637 T11264 T11265 advmod even,in
R7638 T11265 T11247 prep in,reduce
R7639 T11266 T11267 amod untreated,joints
R764 T954 T955 neg not,understood
R7640 T11267 T11265 pobj joints,in
R7641 T11268 T11247 punct ",",reduce
R7642 T11269 T11247 prep in,reduce
R7643 T11270 T11275 preconj both,setting
R7644 T11271 T11275 det a,setting
R7645 T11272 T11275 nmod prophylactic,setting
R7646 T11273 T11272 cc and,prophylactic
R7647 T11274 T11275 amod therapeutic,setting
R7648 T11275 T11269 pobj setting,in
R7649 T11276 T11245 punct .,shown
R765 T955 T955 ROOT understood,understood
R7650 T11277 T11278 nummod A20,expression
R7651 T11278 T11283 nsubjpass expression,associated
R7652 T11279 T11278 prep in,expression
R7653 T11280 T11281 amod synovial,tissue
R7654 T11281 T11279 pobj tissue,in
R7655 T11282 T11283 auxpass was,associated
R7656 T11283 T11283 ROOT associated,associated
R7657 T11284 T11283 prep with,associated
R7658 T11285 T11284 pobj inhibition,with
R7659 T11286 T11285 prep of,inhibition
R766 T956 T955 punct ",",understood
R7660 T11287 T11288 amod NF-κB,activity
R7661 T11288 T11286 pobj activity,of
R7662 T11289 T11283 cc and,associated
R7663 T11290 T11291 amod decreased,levels
R7664 T11291 T11283 conj levels,associated
R7665 T11292 T11291 prep of,levels
R7666 T11293 T11292 pobj TNF,of
R7667 T11294 T11293 punct ",",TNF
R7668 T11295 T11293 conj IL-1β,TNF
R7669 T11296 T11295 punct ",",IL-1β
R767 T957 T955 cc but,understood
R7670 T11297 T11295 conj IL-6,IL-1β
R7671 T11298 T11297 punct ",",IL-6
R7672 T11299 T11300 amod soluble,RANKL
R7673 T11300 T11297 conj RANKL,IL-6
R7674 T11301 T11300 punct ",",RANKL
R7675 T11302 T11304 amod monocyte,protein
R7676 T11303 T11304 compound chemo-attractant,protein
R7677 T11304 T11300 appos protein,RANKL
R7678 T11305 T11304 nummod 1,protein
R7679 T11306 T11300 punct ",",RANKL
R768 T958 T961 nsubjpass it,accepted
R7680 T11307 T11300 cc and,RANKL
R7681 T11308 T11300 conj IL-17,RANKL
R7682 T11309 T11283 punct ",",associated
R7683 T11310 T11283 advcl suggesting,associated
R7684 T11311 T11313 mark that,induces
R7685 T11312 T11313 nsubj A20,induces
R7686 T11313 T11310 ccomp induces,suggesting
R7687 T11314 T11316 det a,effect
R7688 T11315 T11316 amod protective,effect
R7689 T11316 T11313 dobj effect,induces
R769 T959 T961 auxpass is,accepted
R7690 T11317 T11316 prep in,effect
R7691 T11318 T11320 amod collagen-induced,mice
R7692 T11319 T11320 compound arthritis,mice
R7693 T11320 T11317 pobj mice,in
R7694 T11321 T11313 prep through,induces
R7695 T11322 T11321 pobj suppression,through
R7696 T11323 T11322 prep of,suppression
R7697 T11324 T11325 amod NF-κB,activation
R7698 T11325 T11323 pobj activation,of
R7699 T11326 T11325 cc and,activation
R770 T960 T961 advmod well,accepted
R7700 T11327 T11331 punct NF,expression
R7701 T11328 T11329 punct -,κB-dependent
R7702 T11329 T11331 amod κB-dependent,expression
R7703 T11330 T11331 compound gene,expression
R7704 T11331 T11313 npadvmod expression,induces
R7705 T11332 T11331 appos [,expression
R7706 T11333 T11334 nummod 51,]
R7707 T11334 T11331 appos ],expression
R7708 T11335 T11283 punct .,associated
R7709 T11336 T11341 mark Because,known
R771 T961 T955 conj accepted,understood
R7710 T11337 T11341 nsubjpass TNF,known
R7711 T11338 T11337 cc and,TNF
R7712 T11339 T11337 conj IL-1β,TNF
R7713 T11340 T11341 auxpass are,known
R7714 T11341 T11370 advcl known,explain
R7715 T11342 T11343 aux to,mediate
R7716 T11343 T11341 xcomp mediate,known
R7717 T11344 T11343 dobj synovitis,mediate
R7718 T11345 T11343 punct ",",mediate
R7719 T11346 T11347 compound pannus,formation
R772 T962 T968 mark that,plays
R7720 T11347 T11343 conj formation,mediate
R7721 T11348 T11347 punct ",",formation
R7722 T11349 T11347 cc and,formation
R7723 T11350 T11347 conj erosion,formation
R7724 T11351 T11350 prep of,erosion
R7725 T11352 T11351 pobj cartilage,of
R7726 T11353 T11352 cc and,cartilage
R7727 T11354 T11352 conj bone,cartilage
R7728 T11355 T11347 prep in,formation
R7729 T11356 T11355 pobj RA,in
R773 T963 T968 nsubj activation,plays
R7730 T11357 T11370 punct ",",explain
R7731 T11358 T11361 det the,levels
R7732 T11359 T11361 amod decreased,levels
R7733 T11360 T11361 compound serum,levels
R7734 T11361 T11370 nsubj levels,explain
R7735 T11362 T11361 prep of,levels
R7736 T11363 T11362 pobj TNF,of
R7737 T11364 T11363 cc and,TNF
R7738 T11365 T11363 conj IL-1β,TNF
R7739 T11366 T11361 prep in,levels
R774 T964 T963 prep of,activation
R7740 T11367 T11368 amod A20-transduced,mice
R7741 T11368 T11366 pobj mice,in
R7742 T11369 T11370 aux might,explain
R7743 T11370 T11370 ROOT explain,explain
R7744 T11371 T11373 det the,effects
R7745 T11372 T11373 amod beneficial,effects
R7746 T11373 T11370 dobj effects,explain
R7747 T11374 T11373 prep in,effects
R7748 T11375 T11378 det the,pathological
R7749 T11376 T11378 amod clinical,pathological
R775 T965 T967 amod NF-κB-dependent,expression
R7750 T11377 T11378 punct ",",pathological
R7751 T11378 T11374 pobj pathological,in
R7752 T11379 T11373 punct ",",effects
R7753 T11380 T11373 cc and,effects
R7754 T11381 T11382 amod radiological,findings
R7755 T11382 T11373 conj findings,effects
R7756 T11383 T11370 punct .,explain
R7757 T11384 T11385 det This,study
R7758 T11385 T11387 nsubj study,demonstrated
R7759 T11386 T11387 advmod also,demonstrated
R776 T966 T967 compound gene,expression
R7760 T11387 T11387 ROOT demonstrated,demonstrated
R7761 T11388 T11391 mark that,leads
R7762 T11389 T11390 nummod A20,overexpression
R7763 T11390 T11391 nsubj overexpression,leads
R7764 T11391 T11387 ccomp leads,demonstrated
R7765 T11392 T11391 prep to,leads
R7766 T11393 T11394 det a,decrease
R7767 T11394 T11392 pobj decrease,to
R7768 T11395 T11394 prep in,decrease
R7769 T11396 T11397 det the,number
R777 T967 T964 pobj expression,of
R7770 T11397 T11395 pobj number,in
R7771 T11398 T11397 prep of,number
R7772 T11399 T11400 amod activated,osteoclasts
R7773 T11400 T11398 pobj osteoclasts,of
R7774 T11401 T11400 prep in,osteoclasts
R7775 T11402 T11403 amod joint,tissue
R7776 T11403 T11401 pobj tissue,in
R7777 T11404 T11387 punct .,demonstrated
R7778 T11405 T11408 nsubj A20,minimise
R7779 T11406 T11408 aux might,minimise
R778 T968 T961 ccomp plays,accepted
R7780 T11407 T11408 advmod therefore,minimise
R7781 T11408 T11408 ROOT minimise,minimise
R7782 T11409 T11410 amod joint,destruction
R7783 T11410 T11408 dobj destruction,minimise
R7784 T11411 T11408 prep through,minimise
R7785 T11412 T11411 pcomp decreasing,through
R7786 T11413 T11415 det the,number
R7787 T11414 T11415 amod osteoclast,number
R7788 T11415 T11412 dobj number,decreasing
R7789 T11416 T11415 cc and,number
R779 T969 T971 det a,role
R7790 T11417 T11415 conj activity,number
R7791 T11418 T11408 punct .,minimise
R7792 T11419 T11421 nsubj It,be
R7793 T11420 T11421 aux will,be
R7794 T11421 T11421 ROOT be,be
R7795 T11422 T11421 acomp interesting,be
R7796 T11423 T11424 aux to,analyse
R7797 T11424 T11421 xcomp analyse,be
R7798 T11425 T11424 prep in,analyse
R7799 T11426 T11425 pobj future,in
R780 T970 T971 amod key,role
R7800 T11427 T11428 det the,susceptibility
R7801 T11428 T11424 dobj susceptibility,analyse
R7802 T11429 T11428 prep of,susceptibility
R7803 T11430 T11432 amod conditional,mice
R7804 T11431 T11432 compound knockout,mice
R7805 T11432 T11429 pobj mice,of
R7806 T11433 T11434 nsubj that,lack
R7807 T11434 T11432 relcl lack,mice
R7808 T11435 T11434 dobj A20,lack
R7809 T11436 T11435 prep in,A20
R781 T971 T968 dobj role,plays
R7810 T11437 T11439 amod specific,types
R7811 T11438 T11439 compound cell,types
R7812 T11439 T11436 pobj types,in
R7813 T11440 T11441 amod such,as
R7814 T11441 T11439 prep as,types
R7815 T11442 T11443 amod synovial,fibroblasts
R7816 T11443 T11441 pobj fibroblasts,as
R7817 T11444 T11443 punct ",",fibroblasts
R7818 T11445 T11443 conj macrophages,fibroblasts
R7819 T11446 T11445 punct ",",macrophages
R782 T972 T971 prep in,role
R7820 T11447 T11448 amod dendritic,cells
R7821 T11448 T11445 conj cells,macrophages
R7822 T11449 T11445 punct ",",macrophages
R7823 T11450 T11451 compound B,cells
R7824 T11451 T11445 conj cells,macrophages
R7825 T11452 T11451 cc or,cells
R7826 T11453 T11454 compound T,cells
R7827 T11454 T11451 conj cells,cells
R7828 T11455 T11421 punct .,be
R7829 T11456 T11467 advmod Importantly,associated
R783 T973 T974 det the,development
R7830 T11457 T11467 punct ",",associated
R7831 T11458 T11459 amod several,SNPs
R7832 T11459 T11467 nsubjpass SNPs,associated
R7833 T11460 T11459 prep in,SNPs
R7834 T11461 T11464 det the,locus
R7835 T11462 T11464 amod human,locus
R7836 T11463 T11464 compound A20,locus
R7837 T11464 T11460 pobj locus,in
R7838 T11465 T11467 aux have,associated
R7839 T11466 T11467 auxpass been,associated
R784 T974 T972 pobj development,in
R7840 T11467 T11467 ROOT associated,associated
R7841 T11468 T11467 prep with,associated
R7842 T11469 T11470 amod increased,susceptibility
R7843 T11470 T11468 pobj susceptibility,with
R7844 T11471 T11470 prep to,susceptibility
R7845 T11472 T11471 pobj development,to
R7846 T11473 T11472 prep of,development
R7847 T11474 T11475 amod autoimmune,pathologies
R7848 T11475 T11473 pobj pathologies,of
R7849 T11476 T11477 punct (,reviewed
R785 T975 T974 prep of,development
R7850 T11477 T11475 acl reviewed,pathologies
R7851 T11495 T11494 prep in,mutations
R7852 T11478 T11477 prep in,reviewed
R7853 T11496 T11498 det the,locus
R7854 T11479 T11478 pobj [,in
R7855 T11497 T11498 compound A20,locus
R7856 T11498 T11495 pobj locus,in
R7857 T11480 T11481 nummod 52,]
R7858 T11499 T11494 prep in,mutations
R7859 T11500 T11502 det the,chromosome
R786 T976 T975 pobj RA,of
R7860 T11481 T11479 appos ],[
R7861 T11501 T11502 amod 6q23,chromosome
R7862 T11502 T11499 pobj chromosome,in
R7863 T11503 T11502 cc and,chromosome
R7864 T11482 T11479 punct ),[
R7865 T11504 T11502 conj susceptibility,chromosome
R7866 T11505 T11504 prep to,susceptibility
R7867 T11506 T11507 compound RA,[
R7868 T11483 T11467 punct .,associated
R7869 T11507 T11505 pobj [,to
R787 T977 T974 cc and,development
R7870 T11508 T11509 nummod 52,]
R7871 T11509 T11507 appos ],[
R7872 T11510 T11489 punct .,revealed
R7873 T11484 T11487 amod Several,studies
R7874 T11511 T11517 mark Although,located
R7875 T11512 T11514 det the,variants
R7876 T11485 T11486 compound genome-wide,association
R7877 T11513 T11514 amod identified,variants
R7878 T11514 T11517 nsubjpass variants,located
R7879 T11515 T11517 auxpass are,located
R788 T978 T981 amod many,diseases
R7880 T11486 T11487 compound association,studies
R7881 T11516 T11517 neg not,located
R7882 T11517 T11524 advcl located,thought
R7883 T11518 T11517 prep in,located
R7884 T11487 T11489 nsubj studies,revealed
R7885 T11519 T11520 det a,gene
R7886 T11520 T11518 pobj gene,in
R7887 T11521 T11524 punct ",",thought
R7888 T11488 T11489 advmod also,revealed
R7889 T11522 T11524 nsubjpass they,thought
R789 T979 T981 amod other,diseases
R7890 T11523 T11524 auxpass are,thought
R7891 T11489 T11489 ROOT revealed,revealed
R7892 T11524 T11524 ROOT thought,thought
R7893 T11525 T11526 aux to,influence
R7894 T11526 T11524 xcomp influence,thought
R7895 T11527 T11526 dobj A20,influence
R7896 T11490 T11492 det a,association
R7897 T11528 T11526 prep as,influence
R7898 T11529 T11531 poss its,gene
R7899 T11491 T11492 amod clear,association
R790 T980 T981 amod autoimmune,diseases
R7900 T11530 T11531 amod nearest,gene
R7901 T11531 T11528 pobj gene,as
R7902 T11532 T11531 punct (,gene
R7903 T11533 T11531 appos ~,gene
R7904 T11492 T11489 dobj association,revealed
R7905 T11534 T11535 nummod 150,kb
R7906 T11535 T11533 appos kb,~
R7907 T11493 T11492 prep between,association
R7908 T11536 T11535 amod downstream,kb
R7909 T11537 T11536 prep of,downstream
R791 T981 T974 conj diseases,development
R7910 T11538 T11537 pobj A20,of
R7911 T11494 T11493 pobj mutations,between
R7912 T11539 T11535 punct ),kb
R7913 T11540 T11531 punct ",",gene
R7914 T11541 T11542 advmod probably,by
R7915 T11592 T11589 dobj activity,affect
R7916 T11542 T11526 prep by,influence
R7917 T11543 T11544 det the,presence
R7918 T11544 T11542 pobj presence,by
R7919 T11545 T11544 prep of,presence
R792 T982 T961 punct .,accepted
R7920 T11593 T11592 cc and,activity
R7921 T11546 T11549 amod potential,elements
R7922 T11547 T11549 amod regulatory,elements
R7923 T11548 T11549 compound DNA,elements
R7924 T11594 T11596 advmod how,cause
R7925 T11549 T11545 pobj elements,of
R7926 T11550 T11549 prep in,elements
R7927 T11551 T11552 det this,region
R7928 T11595 T11596 nsubj they,cause
R7929 T11552 T11550 pobj region,in
R793 T983 T984 nsubj NF-κB,represents
R7930 T11553 T11524 punct .,thought
R7931 T11554 T11557 mark As,required
R7932 T11596 T11601 advcl cause,remain
R7933 T11555 T11557 nsubjpass A20,required
R7934 T11556 T11557 auxpass is,required
R7935 T11557 T11576 advcl required,reveal
R7936 T11558 T11557 prep for,required
R7937 T11597 T11596 dobj RA,cause
R7938 T11559 T11558 pobj termination,for
R7939 T11560 T11559 prep of,termination
R794 T984 T984 ROOT represents,represents
R7940 T11561 T11562 amod TNF-induced,signals
R7941 T11598 T11601 punct ",",remain
R7942 T11562 T11560 pobj signals,of
R7943 T11563 T11557 punct ",",required
R7944 T11564 T11557 cc and,required
R7945 T11565 T11566 nsubj TNF,is
R7946 T11566 T11557 conj is,required
R7947 T11567 T11570 det the,cytokine
R7948 T11599 T11601 advmod however,remain
R7949 T11568 T11570 amod primary,cytokine
R795 T985 T986 det a,family
R7950 T11569 T11570 amod inflammatory,cytokine
R7951 T11570 T11566 attr cytokine,is
R7952 T11571 T11570 prep in,cytokine
R7953 T11600 T11601 punct ",",remain
R7954 T11572 T11571 pobj RA,in
R7955 T11573 T11576 punct ",",reveal
R7956 T11574 T11575 det these,findings
R7957 T11575 T11576 nsubj findings,reveal
R7958 T11601 T11601 ROOT remain,remain
R7959 T11576 T11576 ROOT reveal,reveal
R796 T986 T984 dobj family,represents
R7960 T11577 T11576 dobj A20,reveal
R7961 T11602 T11601 acomp unclear,remain
R7962 T11578 T11576 prep as,reveal
R7963 T11579 T11582 det a,locus
R7964 T11580 T11581 compound candidate,susceptibility
R7965 T11603 T11601 punct .,remain
R7966 T11581 T11582 compound susceptibility,locus
R7967 T11582 T11578 pobj locus,as
R7968 T11583 T11582 prep for,locus
R7969 T11604 T11610 advmod Recently,evaluated
R797 T987 T986 prep of,family
R7970 T11584 T11583 pobj RA,for
R7971 T11585 T11576 punct .,reveal
R7972 T11586 T11589 advmod How,affect
R7973 T11587 T11588 det these,variants
R7974 T11605 T11610 punct ",",evaluated
R7975 T11588 T11589 nsubj variants,affect
R7976 T11589 T11601 advcl affect,remain
R7977 T11590 T11592 amod normal,activity
R7978 T11606 T11610 nsubj Elsby,evaluated
R7979 T11591 T11592 amod A20,activity
R798 T988 T989 advmod structurally,related
R7980 T11607 T11606 cc and,Elsby
R7981 T11608 T11606 conj colleagues,Elsby
R7982 T11609 T11610 advmod functionally,evaluated
R7983 T11610 T11610 ROOT evaluated,evaluated
R7984 T11611 T11610 prep in,evaluated
R7985 T11612 T11611 pobj vitro,in
R7986 T11613 T11615 det the,ability
R7987 T11614 T11615 amod regulatory,ability
R7988 T11615 T11610 dobj ability,evaluated
R7989 T11616 T11615 prep of,ability
R799 T989 T987 pcomp related,of
R7990 T11617 T11619 amod RA-associated,variants
R7991 T11618 T11619 compound SNP,variants
R7992 T11619 T11616 pobj variants,of
R7993 T11620 T11615 prep on,ability
R7994 T11621 T11623 compound A20,activity
R7995 T11622 T11623 compound promoter,activity
R7996 T11623 T11620 pobj activity,on
R7997 T11624 T11610 punct ",",evaluated
R7998 T11625 T11610 cc and,evaluated
R7999 T11626 T11627 aux could,show
R800 T990 T984 cc and,represents
R8000 T11627 T11610 conj show,evaluated
R8001 T11628 T11630 amod repressed,transcription
R8002 T11629 T11630 compound A20,transcription
R8003 T11630 T11627 dobj transcription,show
R8004 T11631 T11630 prep for,transcription
R8005 T11632 T11631 pobj some,for
R8006 T11633 T11632 prep of,some
R8007 T11634 T11635 det the,SNPs
R8008 T11635 T11633 pobj SNPs,of
R8009 T11636 T11627 conj investigated,show
R801 T991 T992 advmod evolutionarily,conserved
R8010 T11637 T11639 nmod [,]
R8011 T11638 T11639 nummod 53,]
R8012 T11639 T11636 dobj ],investigated
R8013 T11640 T11610 punct .,evaluated
R8014 T11641 T11643 nsubj It,be
R8015 T11642 T11643 aux will,be
R8016 T11643 T11643 ROOT be,be
R8017 T11644 T11643 prep of,be
R8018 T11645 T11644 pobj interest,of
R8019 T11646 T11647 aux to,identify
R802 T992 T993 amod conserved,proteins
R8020 T11647 T11643 advcl identify,be
R8021 T11648 T11651 det the,variants
R8022 T11649 T11651 amod actual,variants
R8023 T11650 T11651 amod causal,variants
R8024 T11651 T11647 dobj variants,identify
R8026 T11652 T11647 cc and,identify
R8027 T11653 T11654 aux to,elucidate
R8029 T11654 T11647 conj elucidate,identify
R803 T993 T984 conj proteins,represents
R8031 T11655 T11657 det the,consequences
R8033 T11656 T11657 amod functional,consequences
R8034 T11657 T11654 dobj consequences,elucidate
R8035 T11658 T11657 prep of,consequences
R8037 T11659 T11660 det these,variants
R8039 T11660 T11658 pobj variants,of
R804 T994 T993 punct (,proteins
R8041 T11661 T11643 punct .,be
R8043 T11662 T11682 prep In,be
R8044 T11663 T11664 det this,context
R8046 T11664 T11662 pobj context,In
R8048 T11665 T11682 punct ",",be
R805 T995 T1010 nmod p100,)
R8052 T11666 T11667 nmod knockin,mice
R8055 T11667 T11682 nsubj mice,be
R806 T996 T995 cc or,p100
R8063 T11668 T11667 prep for,mice
R8067 T11669 T11672 det the,SNPs
R807 T997 T995 conj NF-κB2,p100
R8070 T11670 T11672 amod corresponding,SNPs
R8072 T11671 T11672 compound A20,SNPs
R8075 T11672 T11668 pobj SNPs,for
R8077 T11673 T11672 punct ",",SNPs
R808 T998 T997 punct ",",NF-κB2
R8080 T11674 T11672 acl combined,SNPs
R8081 T11675 T11674 prep with,combined
R8083 T11676 T11677 compound mouse,models
R8086 T11677 T11675 pobj models,with
R8087 T11678 T11677 prep for,models
R8088 T11679 T11678 pobj RA,for
R8089 T11680 T11682 punct ",",be
R809 T999 T997 conj p105,NF-κB2
R8090 T11681 T11682 aux will,be
R8091 T11682 T11682 ROOT be,be
R8092 T11683 T11684 advmod very,valuable
R8094 T11684 T11685 amod valuable,tools
R8098 T11685 T11682 attr tools,be
R8099 T11686 T11682 punct .,be
R810 T1000 T999 cc or,p105
R811 T1001 T999 conj NF-κB1,p105
R812 T1002 T1001 punct ",",NF-κB1
R813 T1003 T1001 conj p65,NF-κB1
R814 T1004 T1003 cc or,p65
R815 T1005 T1003 conj RelA,p65
R816 T1006 T1005 punct ",",RelA
R817 T1007 T1005 conj RelB,RelA
R818 T1008 T1007 punct ",",RelB
R819 T1009 T1007 conj c-Rel,RelB
R820 T1010 T993 punct ),proteins
R821 T1011 T1012 nsubj that,function
R822 T1012 T993 relcl function,proteins
R823 T1013 T1012 prep as,function
R824 T1014 T1013 pobj homodimers,as
R825 T1015 T1014 cc or,homodimers
R826 T1016 T1014 conj heterodimers,homodimers
R827 T1017 T1019 nmod [,]
R828 T1018 T1019 nummod 1,]
R829 T1019 T993 conj ],proteins
R830 T1020 T1019 punct ",",]
R831 T1021 T984 cc and,represents
R832 T1022 T1023 mark that,regulate
R833 T1023 T984 conj regulate,represents
R834 T1024 T1025 det the,expression
R835 T1025 T1023 dobj expression,regulate
R836 T1026 T1025 prep of,expression
R837 T1027 T1029 det a,number
R838 T1028 T1029 amod large,number
R839 T1029 T1026 pobj number,of
R840 T1030 T1029 prep of,number
R841 T1031 T1030 pobj genes,of
R842 T1032 T1031 punct -,genes
R843 T1033 T1034 amod such,as
R844 T1034 T1031 prep as,genes
R845 T1035 T1034 pobj TNF,as
R846 T1036 T1035 punct ",",TNF
R847 T1037 T1035 conj IL-1,TNF
R848 T1038 T1037 punct ",",IL-1
R849 T1039 T1037 conj IL-6,IL-1
R850 T1040 T1039 punct ",",IL-6
R851 T1041 T1039 conj cyclo-oxygenase-2,IL-6
R852 T1042 T1041 punct ",",cyclo-oxygenase-2
R853 T1043 T1041 conj chemokines,cyclo-oxygenase-2
R854 T1044 T1043 punct ",",chemokines
R855 T1045 T1048 amod inducible,synthase
R856 T1046 T1047 amod nitric,oxide
R857 T1047 T1048 compound oxide,synthase
R858 T1048 T1043 conj synthase,chemokines
R859 T1049 T1048 punct ",",synthase
R860 T1050 T1048 cc and,synthase
R861 T1051 T1052 compound matrix,metalloproteinases
R862 T1052 T1048 conj metalloproteinases,synthase
R863 T1053 T1056 punct -,involved
R864 T1054 T1056 nsubjpass that,involved
R865 T1055 T1056 auxpass are,involved
R866 T1056 T1025 relcl involved,expression
R867 T1057 T1056 prep in,involved
R868 T1058 T1057 pobj RA,in
R869 T1059 T984 punct .,represents
R870 T1060 T1066 prep In,are
R871 T1061 T1060 pobj addition,In
R872 T1062 T1066 punct ",",are
R873 T1063 T1066 nsubj TNF,are
R874 T1064 T1063 cc and,TNF
R875 T1065 T1063 conj IL-1,TNF
R876 T1066 T1066 ROOT are,are
R8765 T13214 T13215 amod A20-binding,inhibitors
R8766 T13215 T13235 nsubjpass inhibitors,identified
R8767 T13216 T13215 prep of,inhibitors
R8768 T13217 T13218 compound NF-κB,ABIN-1
R8769 T13218 T13216 pobj ABIN-1,of
R877 T1067 T1066 nsubj themselves,are
R8770 T13219 T13218 punct ",",ABIN-1
R8771 T13220 T13218 conj ABIN-2,ABIN-1
R8772 T13221 T13220 cc and,ABIN-2
R8773 T13222 T13220 conj ABIN-3,ABIN-2
R8774 T13223 T13225 punct (,known
R8775 T13224 T13225 advmod also,known
R8776 T13225 T13215 acl known,inhibitors
R8777 T13226 T13225 prep as,known
R8778 T13227 T13226 pobj TNIP-1,as
R8779 T13228 T13227 punct ",",TNIP-1
R878 T1068 T1069 advmod very,potent
R8780 T13229 T13227 appos TNIP-2,TNIP-1
R8781 T13230 T13225 punct ",",known
R8782 T13231 T13225 cc and,known
R8783 T13232 T13215 appos TNIP-3,inhibitors
R8784 T13233 T13215 punct ),inhibitors
R8785 T13234 T13235 auxpass were,identified
R8786 T13235 T13235 ROOT identified,identified
R8787 T13236 T13235 prep as,identified
R8788 T13237 T13238 advmod ubiquitously,expressed
R8789 T13238 T13239 amod expressed,A20
R879 T1069 T1070 amod potent,activators
R8790 T13239 T13240 nsubj A20,interacting
R8791 T13240 T13236 pcomp interacting,as
R8792 T13241 T13240 dobj proteins,interacting
R8793 T13242 T13235 cc and,identified
R8794 T13243 T13244 auxpass were,shown
R8795 T13244 T13235 conj shown,identified
R8796 T13245 T13246 aux to,inhibit
R8797 T13246 T13244 xcomp inhibit,shown
R8798 T13247 T13248 amod NF-κB,activation
R8799 T13248 T13246 dobj activation,inhibit
R880 T1070 T1066 attr activators,are
R8800 T13249 T13248 prep by,activation
R8801 T13250 T13249 pobj TNF,by
R8802 T13251 T13250 cc and,TNF
R8803 T13252 T13255 amod several,stimuli
R8804 T13253 T13255 amod other,stimuli
R8805 T13254 T13255 amod inflammatory,stimuli
R8806 T13255 T13250 conj stimuli,TNF
R8807 T13256 T13255 prep upon,stimuli
R8808 T13257 T13256 pobj overexpression,upon
R8809 T13258 T13235 punct .,identified
R881 T1071 T1070 prep of,activators
R8810 T13259 T13261 mark Because,contain
R8811 T13260 T13261 nsubj ABINs,contain
R8812 T13261 T13270 advcl contain,proposed
R8813 T13262 T13265 det a,motif
R8814 T13263 T13265 amod specific,motif
R8815 T13264 T13265 amod ubiquitin-binding,motif
R8816 T13265 T13261 dobj motif,contain
R8817 T13266 T13270 punct ",",proposed
R8818 T13267 T13270 nsubjpass they,proposed
R8819 T13268 T13270 aux have,proposed
R882 T1072 T1071 pobj NF-κB,of
R8820 T13269 T13270 auxpass been,proposed
R8821 T13270 T13270 ROOT proposed,proposed
R8822 T13271 T13272 aux to,target
R8823 T13272 T13270 xcomp target,proposed
R8824 T13273 T13272 dobj A20,target
R8825 T13274 T13272 prep to,target
R8826 T13275 T13276 amod polyubiquitinated,substrates
R8827 T13276 T13274 pobj substrates,to
R8828 T13277 T13279 compound [,]
R8829 T13278 T13279 compound "43,44",]
R883 T1073 T1072 punct (,NF-κB
R8830 T13279 T13276 appos ],substrates
R8831 T13280 T13270 punct .,proposed
R8832 T13281 T13288 amod Similar,expression
R8833 T13282 T13281 prep to,Similar
R8834 T13283 T13282 pobj A20,to
R8835 T13284 T13283 punct ",",A20
R8836 T13285 T13283 conj ABIN-1,A20
R8837 T13286 T13285 cc and,ABIN-1
R8838 T13287 T13288 compound ABIN-3,expression
R8839 T13288 T13289 nsubj expression,is
R884 T1074 T1072 acl reviewed,NF-κB
R8840 T13289 T13289 ROOT is,is
R8841 T13290 T13291 advmod NF-κB,dependent
R8842 T13291 T13289 acomp dependent,is
R8843 T13292 T13289 punct ",",is
R8844 T13293 T13289 advcl implicating,is
R8845 T13294 T13296 det a,role
R8846 T13295 T13296 amod potential,role
R8847 T13296 T13293 dobj role,implicating
R8848 T13297 T13296 prep for,role
R8849 T13298 T13300 det the,complex
R885 T1075 T1074 prep in,reviewed
R8850 T13299 T13300 compound A20/ABIN,complex
R8851 T13300 T13297 pobj complex,for
R8852 T13301 T13300 prep in,complex
R8853 T13302 T13305 det the,regulation
R8854 T13303 T13305 amod negative,regulation
R8855 T13304 T13305 compound feedback,regulation
R8856 T13305 T13301 pobj regulation,in
R8857 T13306 T13305 prep of,regulation
R8858 T13307 T13308 amod NF-κB,activation
R8859 T13308 T13306 pobj activation,of
R886 T1076 T1075 pobj [,in
R8860 T13309 T13310 punct (,reviewed
R8861 T13310 T13296 acl reviewed,role
R8862 T13311 T13310 prep in,reviewed
R8863 T13312 T13311 pobj [,in
R8864 T13313 T13314 nummod 54,]
R8865 T13314 T13312 appos ],[
R8866 T13315 T13312 punct ),[
R8867 T13316 T13289 punct .,is
R8868 T13317 T13324 advmod Unexpectedly,exhibit
R8869 T13318 T13324 punct ",",exhibit
R887 T1077 T1078 nummod "2,3",]
R8870 T13319 T13320 preconj both,ABIN-1-deficient
R8871 T13320 T13324 amod ABIN-1-deficient,exhibit
R8872 T13321 T13320 cc and,ABIN-1-deficient
R8873 T13322 T13320 conj ABIN-2-deficient,ABIN-1-deficient
R8874 T13323 T13324 nsubj mice,exhibit
R8875 T13324 T13324 ROOT exhibit,exhibit
R8876 T13325 T13326 advmod only,slightly
R8877 T13326 T13327 advmod slightly,increased
R8878 T13327 T13331 amod increased,responses
R8879 T13328 T13327 cc or,increased
R888 T1078 T1076 appos ],[
R8880 T13329 T13331 amod normal,responses
R8881 T13330 T13331 compound NF-κB,responses
R8882 T13331 T13324 dobj responses,exhibit
R8883 T13332 T13331 punct ",",responses
R8884 T13333 T13331 advmod respectively,responses
R8885 T13334 T13331 punct ",",responses
R8886 T13335 T13336 advmod possibly,reflecting
R8887 T13336 T13324 advcl reflecting,exhibit
R8888 T13337 T13340 amod redundant,activities
R8889 T13338 T13340 compound NF-κB,activities
R889 T1079 T1076 punct ),[
R8890 T13339 T13340 compound inhibitory,activities
R8891 T13340 T13336 dobj activities,reflecting
R8892 T13341 T13340 prep of,activities
R8893 T13342 T13346 amod multiple,]
R8894 T13343 T13344 compound ABINs,[
R8895 T13344 T13346 compound [,]
R8896 T13345 T13346 compound "55,56",]
R8897 T13346 T13341 pobj ],of
R8898 T13347 T13324 punct .,exhibit
R8899 T13348 T13349 compound Functional,ABIN-3
R890 T1080 T1066 punct .,are
R8900 T13349 T13351 nsubjpass ABIN-3,expressed
R8901 T13350 T13351 auxpass is,expressed
R8902 T13351 T13351 ROOT expressed,expressed
R8903 T13352 T13351 prep in,expressed
R8904 T13353 T13352 pobj humans,in
R8905 T13354 T13351 punct ",",expressed
R8906 T13355 T13351 cc but,expressed
R8907 T13356 T13358 nsubj mice,express
R8908 T13357 T13358 advmod only,express
R8909 T13358 T13351 conj express,expressed
R891 T1081 T1082 amod NF-κB,activation
R8910 T13359 T13363 det a,form
R8911 T13360 T13363 amod truncated,form
R8912 T13361 T13360 cc and,truncated
R8913 T13362 T13360 conj inactive,truncated
R8914 T13363 T13358 dobj form,express
R8915 T13364 T13363 acl lacking,form
R8916 T13365 T13368 det the,domain
R8917 T13366 T13368 amod crucial,domain
R8918 T13367 T13368 compound ubiquitin-binding,domain
R8919 T13368 T13364 dobj domain,lacking
R892 T1082 T1085 nsubjpass activation,detected
R8920 T13369 T13371 nmod [,]
R8921 T13370 T13371 nummod 57,]
R8922 T13371 T13368 appos ],domain
R8923 T13372 T13358 punct .,express
R8924 T13373 T13380 prep As,inhibits
R8925 T13374 T13373 prep for,As
R8926 T13375 T13374 pobj A20,for
R8927 T13376 T13380 punct ",",inhibits
R8928 T13377 T13380 nsubj ABIN-1,inhibits
R8929 T13378 T13380 advmod also,inhibits
R893 T1083 T1085 aux can,detected
R8930 T13379 T13380 advmod strongly,inhibits
R8931 T13380 T13380 ROOT inhibits,inhibits
R8932 T13381 T13382 amod TNF-induced,apoptosis
R8933 T13382 T13383 compound apoptosis,[
R8934 T13383 T13380 dobj [,inhibits
R8935 T13384 T13385 nummod 58,]
R8936 T13385 T13390 nmod ],mice
R8937 T13386 T13385 punct ",",]
R8938 T13387 T13385 cc and,]
R8939 T13388 T13385 conj ABIN-1,]
R894 T1084 T1085 auxpass be,detected
R8940 T13389 T13390 amod deficient,mice
R8941 T13390 T13391 nsubj mice,die
R8942 T13391 T13380 conj die,inhibits
R8943 T13392 T13393 advmod embryonically,due
R8944 T13393 T13391 prep due,die
R8945 T13394 T13398 nmod to,apoptosis
R8946 T13395 T13398 amod TNF-dependent,apoptosis
R8947 T13396 T13397 amod foetal,liver
R8948 T13397 T13398 compound liver,apoptosis
R8949 T13398 T13393 xcomp apoptosis,due
R895 T1085 T1104 ccomp detected,demonstrate
R8950 T13399 T13401 nmod [,]
R8951 T13400 T13401 nummod 56,]
R8952 T13401 T13398 appos ],apoptosis
R8953 T13402 T13391 punct .,die
R8954 T13403 T13410 advcl Using,identified
R8955 T13404 T13406 nmod oligonucleotide,analysis
R8956 T13405 T13406 compound microarray,analysis
R8957 T13406 T13403 dobj analysis,Using
R8958 T13407 T13410 punct ",",identified
R8959 T13408 T13410 nsubjpass ABIN-1,identified
R896 T1086 T1085 prep in,detected
R8960 T13409 T13410 auxpass was,identified
R8961 T13410 T13410 ROOT identified,identified
R8962 T13411 T13410 prep among,identified
R8963 T13412 T13413 amod TNF-induced,genes
R8964 T13413 T13411 pobj genes,among
R8965 T13414 T13410 prep in,identified
R8966 T13415 T13416 amod human,synoviocytes
R8967 T13416 T13414 pobj synoviocytes,in
R8968 T13417 T13410 punct ",",identified
R8969 T13418 T13410 cc and,identified
R897 T1087 T1089 amod cultured,fibroblasts
R8970 T13419 T13420 amod high,levels
R8971 T13420 T13425 nsubjpass levels,detected
R8972 T13421 T13420 prep of,levels
R8973 T13422 T13423 compound ABIN-1,mRNA
R8974 T13423 T13421 pobj mRNA,of
R8975 T13424 T13425 auxpass were,detected
R8976 T13425 T13410 conj detected,identified
R8977 T13426 T13425 prep in,detected
R8978 T13427 T13429 compound RA,biopsies
R8979 T13428 T13429 compound tissue,biopsies
R898 T1088 T1089 amod synovial,fibroblasts
R8980 T13429 T13426 pobj biopsies,in
R8981 T13430 T13425 punct ",",detected
R8982 T13431 T13425 advcl indicating,detected
R8983 T13432 T13434 det a,role
R8984 T13433 T13434 amod potential,role
R8985 T13434 T13431 dobj role,indicating
R8986 T13435 T13434 prep for,role
R8987 T13436 T13435 pobj ABIN-1,for
R8988 T13437 T13431 punct ",",indicating
R8989 T13438 T13439 advmod together,with
R899 T1089 T1086 pobj fibroblasts,in
R8990 T13439 T13425 prep with,detected
R8991 T13440 T13439 pobj A20,with
R8992 T13441 T13425 punct ",",detected
R8993 T13442 T13425 prep in,detected
R8994 T13443 T13446 det the,regulation
R8995 T13444 T13446 amod negative,regulation
R8996 T13445 T13446 compound feedback,regulation
R8997 T13446 T13442 pobj regulation,in
R8998 T13447 T13446 prep of,regulation
R8999 T13448 T13449 compound NF-κB,signalling
R900 T1090 T1089 cc and,fibroblasts
R9000 T13449 T13447 pobj signalling,of
R9001 T13450 T13449 cc and,signalling
R9002 T13451 T13452 det the,pathogenesis
R9003 T13452 T13449 conj pathogenesis,signalling
R9004 T13453 T13452 prep of,pathogenesis
R9005 T13454 T13455 compound RA,[
R9006 T13455 T13453 pobj [,of
R9007 T13456 T13457 nummod 59,]
R9008 T13457 T13452 appos ],pathogenesis
R9009 T13458 T13425 punct .,detected
R901 T1091 T1092 amod synovial,tissue
R9010 T13459 T13480 prep In,shown
R9011 T13460 T13462 det a,study
R9012 T13461 T13462 amod recent,study
R9013 T13462 T13459 pobj study,In
R9014 T13463 T13480 punct ",",shown
R9015 T13464 T13480 nsubjpass inhibition,shown
R9016 T13465 T13464 prep of,inhibition
R9017 T13466 T13467 compound TLR,responses
R9018 T13467 T13465 pobj responses,of
R9019 T13468 T13467 prep by,responses
R902 T1092 T1089 conj tissue,fibroblasts
R9020 T13469 T13472 amod immunoreceptor,motif
R9021 T13470 T13472 amod tyrosine-based,motif
R9022 T13471 T13472 compound activation,motif
R9023 T13472 T13468 pobj motif,by
R9024 T13473 T13474 punct (,ITAM
R9025 T13474 T13472 appos ITAM,motif
R9026 T13475 T13474 punct ),ITAM
R9027 T13476 T13472 punct -,motif
R9028 T13477 T13478 amod coupled,receptors
R9029 T13478 T13480 nsubjpass receptors,shown
R903 T1093 T1092 prep from,tissue
R9030 T13479 T13480 auxpass was,shown
R9031 T13480 T13480 ROOT shown,shown
R9032 T13481 T13482 aux to,depend
R9033 T13482 T13480 xcomp depend,shown
R9034 T13483 T13482 prep on,depend
R9035 T13484 T13485 det the,expression
R9036 T13485 T13483 pobj expression,on
R9037 T13486 T13485 prep of,expression
R9038 T13487 T13490 det the,proteins
R9039 T13488 T13490 amod NF-κB,proteins
R904 T1094 T1095 compound RA,patients
R9040 T13489 T13490 compound inhibitory,proteins
R9041 T13490 T13486 pobj proteins,of
R9042 T13491 T13485 appos ABIN-3,expression
R9043 T13492 T13491 cc and,ABIN-3
R9044 T13493 T13491 conj A20,ABIN-3
R9045 T13494 T13480 punct .,shown
R9046 T13495 T13505 advmod Moreover,suppressed
R9047 T13496 T13505 punct ",",suppressed
R9048 T13497 T13499 det this,effect
R9049 T13498 T13499 amod protective,effect
R905 T1095 T1093 pobj patients,from
R9050 T13499 T13505 nsubjpass effect,suppressed
R9051 T13500 T13499 prep of,effect
R9052 T13501 T13502 det the,ITAM
R9053 T13502 T13500 pobj ITAM,of
R9054 T13503 T13505 auxpass was,suppressed
R9055 T13504 T13505 advmod strongly,suppressed
R9056 T13505 T13505 ROOT suppressed,suppressed
R9057 T13506 T13505 prep in,suppressed
R9058 T13507 T13508 amod inflammatory,arthritis
R9059 T13508 T13506 pobj arthritis,in
R906 T1096 T1092 punct ",",tissue
R9060 T13509 T13510 amod synovial,macrophages
R9061 T13510 T13511 compound macrophages,[
R9062 T13511 T13505 dobj [,suppressed
R9063 T13512 T13513 nummod 60,]
R9064 T13513 T13511 appos ],[
R9065 T13514 T13505 punct .,suppressed
R9066 T13515 T13521 advmod Interestingly,associated
R9067 T13516 T13521 punct ",",associated
R9068 T13517 T13518 amod ABIN-1,polymorphisms
R9069 T13518 T13521 nsubjpass polymorphisms,associated
R907 T1097 T1092 cc and,tissue
R9070 T13519 T13521 aux have,associated
R9071 T13520 T13521 auxpass been,associated
R9072 T13521 T13521 ROOT associated,associated
R9073 T13522 T13521 prep with,associated
R9074 T13523 T13522 pobj psoriasis,with
R9075 T13524 T13523 cc and,psoriasis
R9076 T13525 T13526 amod systemic,lupus
R9077 T13526 T13523 conj lupus,psoriasis
R9078 T13527 T13521 conj erythematosus,associated
R9079 T13528 T13527 prep in,erythematosus
R908 T1098 T1099 compound animal,models
R9080 T13529 T13528 pobj humans,in
R9081 T13530 T13532 compound [,]
R9082 T13531 T13532 compound "61,62",]
R9083 T13532 T13521 nsubjpass ],associated
R9084 T13533 T13521 punct .,associated
R9085 T13534 T13536 det A,degree
R9086 T13535 T13536 amod high,degree
R9087 T13536 T13549 nsubjpass degree,expected
R9088 T13537 T13536 prep of,degree
R9089 T13538 T13537 pobj overlap,of
R909 T1099 T1104 nsubj models,demonstrate
R9090 T13539 T13538 prep between,overlap
R9091 T13540 T13542 amod systemic,erythematosus
R9092 T13541 T13542 compound lupus,erythematosus
R9093 T13542 T13539 pobj erythematosus,between
R9094 T13543 T13542 cc and,erythematosus
R9095 T13544 T13545 compound RA,susceptibility
R9096 T13545 T13546 compound susceptibility,loci
R9097 T13546 T13542 conj loci,erythematosus
R9098 T13547 T13549 aux might,expected
R9099 T13548 T13549 auxpass be,expected
R910 T1100 T1099 prep of,models
R9100 T13549 T13549 ROOT expected,expected
R9101 T13550 T13554 mark as,show
R9102 T13551 T13553 det the,diseases
R9103 T13552 T13553 nummod two,diseases
R9104 T13553 T13554 nsubj diseases,show
R9105 T13554 T13549 advcl show,expected
R9106 T13555 T13557 det some,overlap
R9107 T13556 T13557 amod clinical,overlap
R9108 T13557 T13554 dobj overlap,show
R9109 T13558 T13557 prep in,overlap
R911 T1101 T1102 amod inflammatory,arthritis
R9110 T13559 T13560 amod joint,involvement
R9111 T13560 T13558 pobj involvement,in
R9112 T13561 T13557 punct ",",overlap
R9113 T13562 T13563 compound autoantibody,production
R9114 T13563 T13557 conj production,overlap
R9115 T13564 T13563 punct ",",production
R9116 T13565 T13566 amod systemic,features
R9117 T13566 T13563 conj features,production
R9118 T13567 T13566 cc and,features
R9119 T13568 T13566 conj response,features
R912 T1102 T1100 pobj arthritis,of
R9120 T13569 T13568 prep to,response
R9121 T13570 T13569 pobj treatments,to
R9122 T13571 T13572 amod such,as
R9123 T13572 T13570 prep as,treatments
R9124 T13573 T13574 compound B-cell,depletion
R9125 T13574 T13572 pobj depletion,as
R9126 T13575 T13574 punct (,depletion
R9127 T13576 T13574 appos rituximab,depletion
R9128 T13577 T13574 punct ),depletion
R9129 T13578 T13549 punct .,expected
R913 T1103 T1104 advmod also,demonstrate
R9130 T13579 T13582 nsubj It,be
R9131 T13580 T13582 aux will,be
R9132 T13581 T13582 advmod therefore,be
R9133 T13582 T13582 ROOT be,be
R9134 T13583 T13582 acomp interesting,be
R9135 T13584 T13585 aux to,investigate
R9136 T13585 T13582 xcomp investigate,be
R9137 T13586 T13601 mark whether,associated
R9138 T13587 T13601 nsubjpass SNPs,associated
R9139 T13588 T13591 nsubjpass that,reported
R914 T1104 T1104 ROOT demonstrate,demonstrate
R9140 T13589 T13591 aux have,reported
R9141 T13590 T13591 auxpass been,reported
R9142 T13591 T13587 relcl reported,SNPs
R9143 T13592 T13594 aux to,associated
R9144 T13593 T13594 auxpass be,associated
R9145 T13594 T13591 xcomp associated,reported
R9146 T13595 T13594 prep with,associated
R9147 T13596 T13598 amod systemic,erythematosus
R9148 T13597 T13598 compound lupus,erythematosus
R9149 T13598 T13595 pobj erythematosus,with
R915 T1105 T1107 det the,role
R9150 T13599 T13601 auxpass are,associated
R9151 T13600 T13601 advmod also,associated
R9152 T13601 T13585 ccomp associated,investigate
R9153 T13602 T13601 prep with,associated
R9154 T13603 T13602 pobj RA,with
R9155 T13604 T13582 punct .,be
R916 T1106 T1107 amod active,role
R917 T1107 T1104 dobj role,demonstrate
R918 T1108 T1107 prep of,role
R919 T1109 T1108 pobj NF-κB,of
R920 T1110 T1107 prep in,role
R921 T1111 T1112 det the,development
R922 T1112 T1110 pobj development,in
R923 T1113 T1112 cc and,development
R924 T1114 T1112 conj progression,development
R925 T1115 T1112 prep of,development
R926 T1116 T1115 pobj RA,of
R927 T1117 T1107 punct (,role
R928 T1118 T1107 acl reviewed,role
R929 T1119 T1118 prep in,reviewed
R930 T1120 T1119 pobj [,in
R931 T1121 T1122 nummod 4,]
R932 T1122 T1120 appos ],[
R933 T1123 T1120 punct ),[
R934 T1124 T1104 punct .,demonstrate
R935 T1125 T1127 det The,course
R936 T1126 T1127 compound time,course
R937 T1127 T1131 nsubj course,appears
R938 T1128 T1127 prep of,course
R939 T1129 T1130 amod NF-κB,activation
R940 T1130 T1128 pobj activation,of
R941 T1131 T1131 ROOT appears,appears
R942 T1132 T1133 aux to,precede
R943 T1133 T1131 xcomp precede,appears
R944 T1134 T1135 det the,onset
R945 T1135 T1133 dobj onset,precede
R946 T1136 T1135 prep of,onset
R947 T1137 T1136 pobj disease,of
R948 T1138 T1135 punct ",",onset
R949 T1139 T1135 cc and,onset
R950 T1140 T1135 conj blockade,onset
R951 T1141 T1135 prep of,onset
R952 T1142 T1141 pobj NF-κB,of
R953 T1143 T1133 prep by,precede
R954 T1144 T1145 amod different,means
R955 T1145 T1143 pobj means,by
R956 T1146 T1131 conj decreases,appears
R957 T1147 T1148 compound disease,severity
R958 T1148 T1146 dobj severity,decreases
R959 T1149 T1151 compound [,]
R960 T1150 T1151 compound "5,6",]
R961 T1151 T1151 ROOT ],]
R962 T1152 T1131 punct .,appears
R963 T1153 T1163 advmod Next,is
R964 T1154 T1153 prep to,Next
R965 T1155 T1156 poss its,role
R966 T1156 T1154 pobj role,to
R967 T1157 T1156 prep in,role
R968 T1158 T1160 amod proinflammatory,expression
R969 T1159 T1160 compound gene,expression
R9695 T14673 T14675 compound Cylindromatosis,Cylindromatosis
R9696 T14674 T14675 compound protein,Cylindromatosis
R9697 T14675 T14682 nsubjpass Cylindromatosis,identified
R9698 T14676 T14677 punct (,CYLD
R9699 T14677 T14675 appos CYLD,Cylindromatosis
R970 T1160 T1157 pobj expression,in
R9700 T14678 T14677 punct ),CYLD
R9701 T14679 T14682 nsubjpass protein,identified
R9702 T14680 T14682 auxpass was,identified
R9703 T14681 T14682 advmod originally,identified
R9704 T14682 T14682 ROOT identified,identified
R9705 T14683 T14682 prep as,identified
R9706 T14684 T14686 det a,suppressor
R9707 T14685 T14686 compound tumour,suppressor
R9708 T14686 T14683 pobj suppressor,as
R9709 T14687 T14686 acl involved,suppressor
R971 T1161 T1163 punct ",",is
R9710 T14688 T14687 prep in,involved
R9711 T14689 T14690 amod familial,cylindromatosis
R9712 T14690 T14691 compound cylindromatosis,[
R9713 T14691 T14688 pobj [,in
R9714 T14692 T14693 nummod 63,]
R9715 T14693 T14691 appos ],[
R9716 T14694 T14682 punct .,identified
R9717 T14695 T14698 nsubjpass CYLD,involved
R9718 T14696 T14698 auxpass is,involved
R9719 T14697 T14698 advmod also,involved
R972 T1162 T1163 nsubj NF-κB,is
R9720 T14698 T14721 ccomp involved,reviewed
R9721 T14699 T14721 punct ",",reviewed
R9722 T14700 T14721 advmod however,reviewed
R9723 T14701 T14721 punct ",",reviewed
R9724 T14702 T14721 prep in,reviewed
R9725 T14703 T14705 amod diverse,processes
R9726 T14704 T14705 amod physiological,processes
R9727 T14705 T14702 pobj processes,in
R9728 T14706 T14705 acl ranging,processes
R9729 T14707 T14706 prep from,ranging
R973 T1163 T1163 ROOT is,is
R9730 T14708 T14707 pobj immunity,from
R9731 T14709 T14708 cc and,immunity
R9732 T14710 T14708 conj inflammation,immunity
R9733 T14711 T14721 prep to,reviewed
R9734 T14712 T14713 compound cell,cycle
R9735 T14713 T14714 compound cycle,progression
R9736 T14714 T14711 pobj progression,to
R9737 T14715 T14714 punct ",",progression
R9738 T14716 T14714 conj spermatogenesis,progression
R9739 T14717 T14716 punct ",",spermatogenesis
R974 T1164 T1163 advmod also,is
R9740 T14718 T14716 cc and,spermatogenesis
R9741 T14719 T14716 conj osteoclastogenesis,spermatogenesis
R9742 T14720 T14721 punct (,reviewed
R9743 T14721 T14721 ROOT reviewed,reviewed
R9744 T14722 T14721 prep in,reviewed
R9745 T14723 T14722 pobj [,in
R9746 T14724 T14725 nummod 64,]
R9747 T14725 T14723 appos ],[
R9748 T14726 T14723 punct ),[
R9749 T14727 T14721 punct .,reviewed
R975 T1165 T1163 acomp essential,is
R9750 T14728 T14729 nsubj CYLD,is
R9751 T14729 T14729 ROOT is,is
R9752 T14730 T14732 det a,enzyme
R9753 T14731 T14732 amod deubiquitinating,enzyme
R9754 T14732 T14729 attr enzyme,is
R9755 T14733 T14735 nsubj that,regulates
R9756 T14734 T14735 advmod negatively,regulates
R9757 T14735 T14732 relcl regulates,enzyme
R9758 T14736 T14737 amod NF-κB,signalling
R9759 T14737 T14735 xcomp signalling,regulates
R976 T1166 T1165 prep for,essential
R9760 T14738 T14737 acl initiated,signalling
R9761 T14739 T14738 agent by,initiated
R9762 T14740 T14739 pobj TNFR,by
R9763 T14741 T14740 punct ",",TNFR
R9764 T14742 T14740 conj RANK,TNFR
R9765 T14743 T14742 cc and,RANK
R9766 T14744 T14742 conj T-cell,RANK
R9767 T14745 T14746 compound receptor,stimulation
R9768 T14746 T14740 appos stimulation,TNFR
R9769 T14747 T14748 punct (,reviewed
R977 T1167 T1166 pobj osteoclastogenesis,for
R9770 T14748 T14737 acl reviewed,signalling
R9771 T14749 T14748 prep in,reviewed
R9772 T14750 T14749 pobj [,in
R9773 T14751 T14752 nummod 64,]
R9774 T14752 T14750 appos ],[
R9775 T14753 T14750 punct ),[
R9776 T14754 T14755 punct (,Figure
R9777 T14755 T14748 appos Figure,reviewed
R9778 T14756 T14755 nummod 1,Figure
R9779 T14757 T14755 punct ),Figure
R978 T1168 T1166 punct ",",for
R9780 T14758 T14755 punct ",",Figure
R9781 T14759 T14755 prep by,Figure
R9782 T14760 T14764 amod deubiquitina-ting,proteins
R9783 T14761 T14764 amod several,proteins
R9784 T14762 T14763 npadvmod NF-κB,signalling
R9785 T14763 T14764 amod signalling,proteins
R9786 T14764 T14759 pobj proteins,by
R9787 T14765 T14764 prep including,proteins
R9788 T14766 T14765 pobj NEMO,including
R9789 T14767 T14766 punct ",",NEMO
R979 T1169 T1170 advmod mainly,by
R9790 T14768 T14766 conj TRAF2,NEMO
R9791 T14769 T14768 punct ",",TRAF2
R9792 T14770 T14768 conj TRAF6,TRAF2
R9793 T14771 T14770 punct ",",TRAF6
R9794 T14772 T14770 conj TRAF7,TRAF6
R9795 T14773 T14772 punct ",",TRAF7
R9796 T14774 T14772 conj RIP1,TRAF7
R9797 T14775 T14774 cc and,RIP1
R9798 T14776 T14774 conj TAK1,RIP1
R9799 T14777 T14755 punct .,Figure
R980 T1170 T1163 prep by,is
R9800 T14778 T14783 nsubjpass Many,targeted
R9801 T14779 T14778 prep of,Many
R9802 T14780 T14779 pobj these,of
R9803 T14781 T14783 auxpass are,targeted
R9804 T14782 T14783 advmod also,targeted
R9805 T14783 T14783 ROOT targeted,targeted
R9806 T14784 T14783 agent by,targeted
R9807 T14785 T14784 pobj A20,by
R9808 T14786 T14783 cc and,targeted
R9809 T14787 T14788 nsubj it,is
R981 T1171 T1170 pcomp mediating,by
R9810 T14788 T14783 conj is,targeted
R9811 T14789 T14788 advmod still,is
R9812 T14790 T14788 neg not,is
R9813 T14791 T14788 acomp clear,is
R9814 T14792 T14795 advmod why,needs
R9815 T14793 T14794 det the,cell
R9816 T14794 T14795 nsubj cell,needs
R9817 T14795 T14788 ccomp needs,is
R9818 T14796 T14802 nsubj A20,control
R9819 T14797 T14799 advmod as,as
R982 T1172 T1173 det the,effects
R9820 T14798 T14799 advmod well,as
R9821 T14799 T14796 cc as,A20
R9822 T14800 T14796 conj CYLD,A20
R9823 T14801 T14802 aux to,control
R9824 T14802 T14795 ccomp control,needs
R9825 T14803 T14804 amod NF-κB,activation
R9826 T14804 T14802 dobj activation,control
R9827 T14805 T14788 punct .,is
R9828 T14806 T14810 mark As,expressed
R9829 T14807 T14810 nsubjpass A20,expressed
R983 T1173 T1171 dobj effects,mediating
R9830 T14808 T14810 auxpass is,expressed
R9831 T14809 T14810 advmod only,expressed
R9832 T14810 T14821 advcl expressed,suggested
R9833 T14811 T14810 prep in,expressed
R9834 T14812 T14814 amod many,types
R9835 T14813 T14814 compound cell,types
R9836 T14814 T14811 pobj types,in
R9837 T14815 T14810 prep upon,expressed
R9838 T14816 T14815 pobj stimulation,upon
R9839 T14817 T14821 punct ",",suggested
R984 T1174 T1173 prep of,effects
R9840 T14818 T14821 nsubjpass it,suggested
R9841 T14819 T14821 aux has,suggested
R9842 T14820 T14821 auxpass been,suggested
R9843 T14821 T14821 ROOT suggested,suggested
R9844 T14822 T14826 mark that,regulates
R9845 T14823 T14824 det this,protein
R9846 T14824 T14826 nsubj protein,regulates
R9847 T14825 T14826 advmod mainly,regulates
R9848 T14826 T14821 ccomp regulates,suggested
R9849 T14827 T14828 amod later,phases
R985 T1175 T1176 compound receptor,activator
R9850 T14828 T14826 dobj phases,regulates
R9851 T14829 T14828 prep of,phases
R9852 T14830 T14831 amod NF-κB,signalling
R9853 T14831 T14829 pobj signalling,of
R9854 T14832 T14826 punct ",",regulates
R9855 T14833 T14836 mark whereas,regulate
R9856 T14834 T14836 nsubj CYLD,regulate
R9857 T14835 T14836 aux would,regulate
R9858 T14836 T14826 advcl regulate,regulates
R9859 T14837 T14836 dobj constitutive,regulate
R986 T1176 T1174 pobj activator,of
R9860 T14838 T14837 cc and,constitutive
R9861 T14839 T14840 amod early,signalling
R9862 T14840 T14837 conj signalling,constitutive
R9863 T14841 T14821 punct .,suggested
R9864 T14842 T14850 prep In,be
R9865 T14843 T14842 pobj addition,In
R9866 T14844 T14850 punct ",",be
R9867 T14845 T14847 poss their,activity
R9868 T14846 T14847 amod relative,activity
R9869 T14847 T14850 nsubj activity,be
R987 T1177 T1176 prep of,activator
R9870 T14848 T14850 aux might,be
R9871 T14849 T14850 advmod also,be
R9872 T14850 T14850 ROOT be,be
R9873 T14851 T14852 npadvmod cell-type,dependent
R9874 T14852 T14855 amod dependent,]
R9875 T14853 T14855 nmod [,]
R9876 T14854 T14855 nummod 64,]
R9877 T14855 T14850 attr ],be
R9878 T14856 T14850 punct .,be
R9879 T14857 T14862 advmod Interestingly,shown
R988 T1178 T1179 amod NF-κB,ligand
R9880 T14858 T14862 punct ",",shown
R9881 T14859 T14862 nsubjpass CYLD,shown
R9882 T14860 T14862 aux has,shown
R9883 T14861 T14862 auxpass been,shown
R9884 T14862 T14862 ROOT shown,shown
R9885 T14863 T14865 aux to,regulate
R9886 T14864 T14865 advmod negatively,regulate
R9887 T14865 T14862 xcomp regulate,shown
R9888 T14866 T14867 compound RANK,signalling
R9889 T14867 T14865 dobj signalling,regulate
R989 T1179 T1177 pobj ligand,of
R9890 T14868 T14867 cc and,signalling
R9891 T14869 T14867 conj osteoclastogenesis,signalling
R9892 T14870 T14867 prep in,signalling
R9893 T14871 T14870 pobj mice,in
R9894 T14872 T14874 nmod [,]
R9895 T14873 T14874 nummod 65,]
R9896 T14874 T14867 appos ],signalling
R9897 T14875 T14862 punct .,shown
R9898 T14876 T14883 nsubj Mice,have
R9899 T14877 T14876 prep with,Mice
R990 T1180 T1181 punct (,RANKL
R9900 T14878 T14880 det a,deficiency
R9901 T14879 T14880 amod genetic,deficiency
R9902 T14880 T14877 pobj deficiency,with
R9903 T14881 T14880 prep of,deficiency
R9904 T14882 T14881 pobj CYLD,of
R9905 T14883 T14883 ROOT have,have
R9906 T14884 T14886 amod aberrant,differentiation
R9907 T14885 T14886 compound osteoclast,differentiation
R9908 T14886 T14883 dobj differentiation,have
R9909 T14887 T14883 cc and,have
R991 T1222 T1221 punct ",",signalling
R9910 T14888 T14883 conj develop,have
R9911 T14889 T14890 amod severe,osteoporosis
R9912 T14890 T14888 dobj osteoporosis,develop
R9913 T14891 T14883 punct .,have
R9914 T14892 T14897 dep Osteoclast,are
R9915 T14893 T14897 nsubj precursors,are
R9916 T14894 T14893 prep of,precursors
R9917 T14895 T14896 det these,mice
R9918 T14896 T14894 pobj mice,of
R9919 T14897 T14897 ROOT are,are
R992 T1181 T1179 appos RANKL,ligand
R9920 T14898 T14897 acomp hyper-responsive,are
R9921 T14899 T14898 prep to,hyper-responsive
R9922 T14900 T14901 amod RANKL-induced,differentiation
R9923 T14901 T14899 pobj differentiation,to
R9924 T14902 T14897 cc and,are
R9925 T14903 T14897 conj produce,are
R9926 T14904 T14907 amod more,osteoclasts
R9927 T14905 T14904 cc and,more
R9928 T14906 T14904 conj larger,more
R9929 T14907 T14903 dobj osteoclasts,produce
R993 T1223 T1221 prep including,signalling
R9930 T14908 T14897 punct .,are
R9931 T14909 T14910 compound CYLD,expression
R9932 T14910 T14913 nsubjpass expression,upregulated
R9933 T14911 T14913 auxpass is,upregulated
R9934 T14912 T14913 advmod markedly,upregulated
R9935 T14913 T14913 ROOT upregulated,upregulated
R9936 T14914 T14913 prep under,upregulated
R9937 T14915 T14914 pobj conditions,under
R9938 T14916 T14915 prep of,conditions
R9939 T14917 T14918 compound RANKL-induced,osteoclastogenesis
R994 T1224 T1223 pobj CD40,including
R9940 T14918 T14916 pobj osteoclastogenesis,of
R9941 T14919 T14913 cc and,upregulated
R9942 T14920 T14921 auxpass is,recruited
R9943 T14921 T14913 conj recruited,upregulated
R9944 T14922 T14921 prep to,recruited
R9945 T14923 T14924 amod ubiquitinated,TRAF6
R9946 T14924 T14922 pobj TRAF6,to
R9947 T14925 T14921 prep via,recruited
R9948 T14926 T14929 det the,protein
R9949 T14927 T14929 amod ubiquitin-binding,protein
R995 T1182 T1163 punct ),is
R9950 T14928 T14929 compound adaptor,protein
R9951 T14929 T14925 pobj protein,via
R9952 T14930 T14921 conj p62,recruited
R9953 T14931 T14933 punct (,known
R9954 T14932 T14933 advmod also,known
R9955 T14933 T14930 acl known,p62
R9956 T14934 T14933 prep as,known
R9957 T14935 T14934 pobj sequestosome,as
R9958 T14936 T14935 nummod 1,sequestosome
R9959 T14937 T14930 punct ),p62
R996 T1183 T1163 punct .,is
R9960 T14938 T14940 nmod [,]
R9961 T14939 T14940 nummod 65,]
R9962 T14940 T14940 ROOT ],]
R9963 T14941 T14940 punct ",",]
R9964 T14942 T14940 acl followed,]
R9965 T14943 T14942 agent by,followed
R9966 T14944 T14946 det the,deubiquitination
R9967 T14945 T14946 amod CYLD-mediated,deubiquitination
R9968 T14946 T14943 pobj deubiquitination,by
R9969 T14947 T14946 prep of,deubiquitination
R997 T1225 T1224 punct ",",CD40
R9970 T14948 T14947 pobj TRAF6,of
R9971 T14949 T14913 punct .,upregulated
R9972 T14950 T14955 prep In,is
R9973 T14951 T14952 det this,context
R9974 T14952 T14950 pobj context,In
R9975 T14953 T14955 punct ",",is
R9976 T14954 T14955 nsubj it,is
R9977 T14955 T14955 ROOT is,is
R9978 T14956 T14955 acomp worth,is
R9979 T14957 T14956 xcomp mentioning,worth
R998 T1184 T1190 nsubj Defects,are
R9980 T14958 T14968 mark that,display
R9981 T14959 T14960 amod transgenic,mice
R9982 T14960 T14968 nsubj mice,display
R9983 T14961 T14960 acl expressing,mice
R9984 T14962 T14964 det a,form
R9985 T14963 T14964 amod mutated,form
R9986 T14964 T14961 dobj form,expressing
R9987 T14965 T14964 prep of,form
R9988 T14966 T14965 pobj p62,of
R9989 T14967 T14968 advmod also,display
R999 T1226 T1224 appos TRAF1,CD40
R9990 T14968 T14955 ccomp display,is
R9991 T14969 T14970 amod abnormal,osteoclastogenesis
R9992 T14970 T14968 dobj osteoclastogenesis,display
R9993 T14971 T14968 cc and,display
R9994 T14972 T14968 conj develop,display
R9995 T14973 T14975 amod progressive,loss
R9996 T14974 T14975 compound bone,loss
R9997 T14975 T14972 dobj loss,develop
R9998 T14976 T14978 nmod [,]
R9999 T14977 T14978 nummod 66,]