PMC:2817507 / 1381-18287 JSON TXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T1284	16-29	NNP	denotes	Intracerebral
T1285	30-40	NN	denotes	hemorrhage
T1286	41-42	-LRB-	denotes	(
T1287	42-45	NNP	denotes	ICH
T1288	45-46	-RRB-	denotes	)
T1289	47-57	VBZ	denotes	represents
T1290	58-60	CD	denotes	10
T1291	60-61	NN	denotes	%
T1292	62-64	CD	denotes	15
T1293	64-65	NN	denotes	%
T1294	66-68	IN	denotes	of
T1295	69-72	DT	denotes	all
T1296	73-80	NNS	denotes	strokes
T1297	81-84	CC	denotes	and
T1298	85-91	VBZ	denotes	occurs
T1299	92-96	IN	denotes	with
T1300	97-107	VBG	denotes	increasing
T1301	108-117	NN	denotes	frequency
T1302	118-120	IN	denotes	as
T1303	121-122	DT	denotes	a
T1304	123-135	NN	denotes	complication
T1305	136-138	IN	denotes	of
T1306	139-142	DT	denotes	the
T1307	143-155	JJ	denotes	thrombolytic
T1308	156-165	NN	denotes	treatment
T1309	166-168	IN	denotes	of
T1310	169-177	JJ	denotes	ischemic
T1311	178-184	NN	denotes	stroke
T1312	184-185	,	denotes	,
T1313	186-191	WDT	denotes	which
T1314	192-194	VBZ	denotes	is
T1315	195-205	VBN	denotes	associated
T1316	206-210	IN	denotes	with
T1317	211-215	JJ	denotes	high
T1318	216-225	NN	denotes	mortality
T1319	226-229	CC	denotes	and
T1320	230-236	JJ	denotes	severe
T1321	237-247	NN	denotes	disability
T1322	248-250	IN	denotes	in
T1323	251-260	NNS	denotes	survivors
T1324	261-262	VBP	denotes	[
T1325	262-263	CD	denotes	1
T1326	263-264	,	denotes	,
T1327	265-266	CD	denotes	2
T1328	266-267	NNP	denotes	]
T1329	267-268	.	denotes	.
T1330	269-274	JJ	denotes	Local
T1331	275-280	NN	denotes	brain
T1332	281-287	NN	denotes	tissue
T1333	288-299	NN	denotes	deformation
T1334	300-307	VBZ	denotes	induces
T1335	308-315	JJ	denotes	primary
T1336	316-321	NN	denotes	brain
T1337	322-328	NN	denotes	damage
T1338	329-334	IN	denotes	after
T1339	335-338	NNP	denotes	ICH
T1340	338-339	:	denotes	;
T1341	340-344	JJR	denotes	more
T1342	345-356	RB	denotes	importantly
T1343	356-357	,	denotes	,
T1344	358-361	DT	denotes	the
T1345	362-376	NN	denotes	excitotoxicity
T1346	377-380	CC	denotes	and
T1347	381-393	JJ	denotes	inflammatory
T1348	394-403	NNS	denotes	responses
T1349	404-406	IN	denotes	in
T1350	407-410	DT	denotes	the
T1351	411-416	NN	denotes	brain
T1352	417-423	NN	denotes	tissue
T1353	424-431	VBN	denotes	induced
T1354	432-434	IN	denotes	by
T1355	435-438	NNP	denotes	ICH
T1356	439-445	NN	denotes	result
T1357	446-448	IN	denotes	in
T1358	449-456	JJ	denotes	further
T1359	457-462	NN	denotes	brain
T1360	463-469	NN	denotes	damage
T1361	470-479	VBG	denotes	following
T1362	480-483	NNP	denotes	ICH
T1363	484-485	NNP	denotes	[
T1364	485-486	CD	denotes	3
T1365	486-487	NNP	denotes	]
T1366	487-488	.	denotes	.
T1367	489-493	DT	denotes	Both
T1368	494-500	NN	denotes	innate
T1369	501-504	CC	denotes	and
T1370	505-513	JJ	denotes	adaptive
T1371	514-540	JJ	denotes	immunological/inflammatory
T1372	541-551	NNS	denotes	mechanisms
T1373	552-556	VBP	denotes	have
T1374	557-561	VBN	denotes	been
T1375	562-569	RB	denotes	clearly
T1376	570-575	VBN	denotes	shown
T1377	576-578	TO	denotes	to
T1378	579-590	VB	denotes	participate
T1379	591-593	IN	denotes	in
T1380	594-597	DT	denotes	the
T1381	598-609	NN	denotes	progression
T1382	610-612	IN	denotes	of
T1383	613-618	NN	denotes	brain
T1384	619-625	NN	denotes	injury
T1385	626-631	IN	denotes	after
T1386	632-640	JJ	denotes	ischemic
T1387	641-647	NN	denotes	stroke
T1388	647-648	.	denotes	.
T1389	649-661	RB	denotes	Nevertheless
T1390	661-662	,	denotes	,
T1391	663-666	WRB	denotes	how
T1392	667-670	DT	denotes	the
T1393	671-683	JJ	denotes	inflammatory
T1394	684-693	NNS	denotes	responses
T1395	694-696	IN	denotes	in
T1396	697-700	NNP	denotes	ICH
T1397	701-704	VBP	denotes	are
T1398	705-714	VBN	denotes	triggered
T1399	715-718	CC	denotes	and
T1400	719-728	VBN	denotes	regulated
T1401	729-736	VBZ	denotes	remains
T1402	737-739	TO	denotes	to
T1403	740-742	VB	denotes	be
T1404	743-753	VBN	denotes	elucidated
T1405	753-754	.	denotes	.
T1406	755-759	NNS	denotes	TLRs
T1407	760-763	VBP	denotes	are
T1408	764-765	DT	denotes	a
T1409	766-772	NN	denotes	family
T1410	773-775	IN	denotes	of
T1411	776-789	NN	denotes	transmembrane
T1412	790-798	NNS	denotes	proteins
T1413	799-802	CC	denotes	and
T1414	803-806	NN	denotes	act
T1415	807-809	IN	denotes	as
T1416	810-816	NN	denotes	signal
T1417	817-829	NN	denotes	transduction
T1418	830-839	NNS	denotes	molecules
T1419	840-841	VBP	denotes	[
T1420	841-842	CD	denotes	4
T1421	842-843	NNP	denotes	]
T1422	843-844	.	denotes	.
T1423	845-855	NNP	denotes	Activation
T1424	856-858	IN	denotes	of
T1425	859-863	NNPS	denotes	TLRs
T1426	864-872	VBZ	denotes	recruits
T1427	873-883	JJ	denotes	downstream
T1428	884-893	VBG	denotes	signaling
T1429	894-902	NNS	denotes	proteins
T1430	903-906	CC	denotes	and
T1431	907-914	NNS	denotes	results
T1432	915-917	IN	denotes	in
T1433	918-931	NN	denotes	transcription
T1434	932-934	IN	denotes	of
T1435	935-940	NNS	denotes	genes
T1436	941-949	VBG	denotes	encoding
T1437	950-973	JJ	denotes	inflammation-associated
T1438	974-983	NNS	denotes	molecules
T1439	984-987	CC	denotes	and
T1440	988-997	NNS	denotes	cytokines
T1441	998-999	VBP	denotes	[
T1442	999-1000	CD	denotes	5
T1443	1000-1001	,	denotes	,
T1444	1002-1003	CD	denotes	6
T1445	1003-1004	NN	denotes	]
T1446	1004-1005	.	denotes	.
T1447	1006-1009	IN	denotes	For
T1448	1010-1017	NN	denotes	example
T1449	1017-1018	,	denotes	,
T1450	1019-1027	VBN	denotes	combined
T1451	1028-1032	IN	denotes	with
T1452	1033-1041	JJ	denotes	specific
T1453	1042-1048	NN	denotes	ligand
T1454	1048-1049	,	denotes	,
T1455	1050-1053	DT	denotes	the
T1456	1054-1064	NN	denotes	activation
T1457	1065-1067	IN	denotes	of
T1458	1068-1072	CD	denotes	TLR4
T1459	1073-1080	VBZ	denotes	induces
T1460	1081-1084	DT	denotes	the
T1461	1085-1100	NN	denotes	phosphorylation
T1462	1101-1103	IN	denotes	of
T1463	1104-1113	NN	denotes	inhibitor
T1464	1114-1116	IN	denotes	of
T1465	1117-1124	NNP	denotes	kappa-B
T1466	1125-1126	-LRB-	denotes	(
T1467	1126-1129	NNP	denotes	IκB
T1468	1129-1130	-RRB-	denotes	)
T1469	1131-1134	CC	denotes	and
T1470	1135-1146	VBZ	denotes	dissociates
T1471	1147-1150	NNP	denotes	IκB
T1472	1151-1155	IN	denotes	from
T1473	1156-1166	NNP	denotes	NF-kappa-B
T1474	1167-1168	-LRB-	denotes	(
T1475	1168-1172	NNP	denotes	NFκB
T1476	1172-1173	-RRB-	denotes	)
T1477	1173-1174	.	denotes	.
T1478	1175-1179	RB	denotes	Then
T1479	1179-1180	,	denotes	,
T1480	1181-1185	NNP	denotes	NFκB
T1481	1186-1199	VBZ	denotes	trans-locates
T1482	1200-1204	IN	denotes	into
T1483	1205-1208	DT	denotes	the
T1484	1209-1216	NN	denotes	nucleus
T1485	1217-1220	CC	denotes	and
T1486	1221-1230	NNS	denotes	activates
T1487	1231-1234	CC	denotes	and
T1488	1235-1244	VBZ	denotes	regulates
T1489	1245-1248	DT	denotes	the
T1490	1249-1262	NN	denotes	transcription
T1491	1263-1265	IN	denotes	of
T1492	1266-1271	NNS	denotes	genes
T1493	1272-1279	VBN	denotes	related
T1494	1280-1282	TO	denotes	to
T1495	1283-1295	JJ	denotes	inflammatory
T1496	1296-1305	NNS	denotes	responses
T1497	1306-1307	VBP	denotes	[
T1498	1307-1308	CD	denotes	5
T1499	1308-1309	,	denotes	,
T1500	1310-1311	CD	denotes	6
T1501	1311-1312	NN	denotes	]
T1502	1312-1313	.	denotes	.
T1503	1314-1318	NNS	denotes	TLRs
T1504	1319-1323	VBP	denotes	play
T1505	1324-1325	DT	denotes	a
T1506	1326-1334	JJ	denotes	critical
T1507	1335-1339	NN	denotes	role
T1508	1340-1342	IN	denotes	in
T1509	1343-1346	DT	denotes	the
T1510	1347-1356	NN	denotes	induction
T1511	1357-1359	IN	denotes	of
T1512	1360-1386	JJ	denotes	immunological/inflammatory
T1513	1387-1396	NNS	denotes	responses
T1514	1397-1400	CC	denotes	and
T1515	1401-1404	VBP	denotes	are
T1516	1405-1415	VBN	denotes	implicated
T1517	1416-1418	IN	denotes	in
T1518	1419-1426	JJ	denotes	several
T1519	1427-1430	NNP	denotes	CNS
T1520	1431-1439	NNS	denotes	diseases
T1521	1439-1440	,	denotes	,
T1522	1441-1445	JJ	denotes	such
T1523	1446-1448	IN	denotes	as
T1524	1449-1459	JJ	denotes	infectious
T1525	1460-1467	NN	denotes	disease
T1526	1467-1468	,	denotes	,
T1527	1469-1479	JJ	denotes	autoimmune
T1528	1480-1487	NN	denotes	disease
T1529	1487-1488	,	denotes	,
T1530	1489-1492	CC	denotes	and
T1531	1493-1501	JJ	denotes	ischemic
T1532	1502-1507	NN	denotes	brain
T1533	1508-1514	NN	denotes	injury
T1534	1515-1516	NN	denotes	[
T1535	1516-1517	CD	denotes	7
T1536	1517-1518	,	denotes	,
T1537	1519-1520	CD	denotes	8
T1538	1520-1521	NN	denotes	]
T1539	1521-1522	.	denotes	.
T1540	1523-1535	VBG	denotes	Accumulating
T1541	1536-1545	NNS	denotes	evidences
T1542	1546-1557	VBP	denotes	demonstrate
T1543	1558-1562	IN	denotes	that
T1544	1563-1567	CD	denotes	TLR4
T1545	1567-1568	,	denotes	,
T1546	1569-1572	DT	denotes	the
T1547	1573-1578	JJ	denotes	first
T1548	1579-1588	JJ	denotes	mammalian
T1549	1589-1592	NNP	denotes	TLR
T1550	1593-1603	VBD	denotes	recognized
T1551	1603-1604	,	denotes	,
T1552	1605-1616	VBZ	denotes	contributes
T1553	1617-1619	TO	denotes	to
T1554	1620-1623	DT	denotes	the
T1555	1624-1632	JJ	denotes	neuronal
T1556	1633-1638	NN	denotes	death
T1557	1638-1639	,	denotes	,
T1558	1640-1645	NN	denotes	blood
T1559	1646-1651	NN	denotes	brain
T1560	1652-1659	NN	denotes	barrier
T1561	1660-1666	NN	denotes	damage
T1562	1666-1667	,	denotes	,
T1563	1668-1673	NN	denotes	brain
T1564	1674-1679	NN	denotes	edema
T1565	1679-1680	,	denotes	,
T1566	1681-1684	CC	denotes	and
T1567	1685-1697	JJ	denotes	inflammatory
T1568	1698-1707	NNS	denotes	responses
T1569	1708-1710	IN	denotes	in
T1570	1711-1714	DT	denotes	the
T1571	1715-1720	NN	denotes	brain
T1572	1721-1727	NN	denotes	injury
T1573	1728-1735	VBN	denotes	induced
T1574	1736-1738	IN	denotes	by
T1575	1739-1747	NN	denotes	ischemia
T1576	1748-1749	NN	denotes	[
T1577	1749-1750	CD	denotes	8
T1578	1750-1751	,	denotes	,
T1579	1752-1753	CD	denotes	9
T1580	1753-1754	NN	denotes	]
T1581	1754-1755	.	denotes	.
T1582	1756-1763	RB	denotes	However
T1583	1763-1764	,	denotes	,
T1584	1765-1771	JJ	denotes	little
T1585	1772-1774	VBZ	denotes	is
T1586	1775-1780	VBN	denotes	known
T1587	1781-1786	IN	denotes	about
T1588	1787-1791	CD	denotes	TLR4
T1589	1792-1794	IN	denotes	in
T1590	1795-1798	DT	denotes	the
T1591	1799-1804	NN	denotes	brain
T1592	1805-1810	IN	denotes	after
T1593	1811-1814	NNP	denotes	ICH
T1594	1814-1815	.	denotes	.
T1595	1816-1818	IN	denotes	In
T1596	1819-1822	DT	denotes	the
T1597	1823-1830	JJ	denotes	present
T1598	1831-1836	NN	denotes	study
T1599	1836-1837	,	denotes	,
T1600	1838-1840	PRP	denotes	we
T1601	1841-1849	VBD	denotes	detected
T1602	1850-1853	DT	denotes	the
T1603	1854-1867	NN	denotes	transcription
T1604	1868-1870	IN	denotes	of
T1605	1871-1875	CD	denotes	TLR4
T1606	1876-1880	NN	denotes	gene
T1607	1881-1884	CC	denotes	and
T1608	1885-1888	DT	denotes	the
T1609	1889-1899	NN	denotes	activation
T1610	1900-1902	IN	denotes	of
T1611	1903-1916	JJ	denotes	TLR4-mediated
T1612	1917-1926	VBG	denotes	signaling
T1613	1927-1929	IN	denotes	in
T1614	1930-1933	DT	denotes	the
T1615	1934-1937	NN	denotes	rat
T1616	1938-1944	NNS	denotes	brains
T1617	1945-1954	VBN	denotes	subjected
T1618	1955-1957	TO	denotes	to
T1619	1958-1970	JJ	denotes	experimental
T1620	1971-1974	NNP	denotes	ICH
T1621	1974-1975	.	denotes	.
T1622	1976-1979	PRP$	denotes	Our
T1623	1980-1984	NNS	denotes	data
T1624	1985-1992	RB	denotes	firstly
T1625	1993-2001	VBD	denotes	provided
T1626	2002-2005	DT	denotes	the
T1627	2006-2015	NN	denotes	knowledge
T1628	2016-2021	IN	denotes	about
T1629	2022-2025	DT	denotes	the
T1630	2026-2038	NN	denotes	distribution
T1631	2039-2041	IN	denotes	of
T1632	2042-2046	CD	denotes	TLR4
T1633	2047-2050	CC	denotes	and
T1634	2051-2054	DT	denotes	the
T1635	2055-2063	JJ	denotes	temporal
T1636	2064-2071	NN	denotes	profile
T1637	2072-2074	IN	denotes	of
T1638	2075-2078	DT	denotes	the
T1639	2079-2089	NN	denotes	activation
T1640	2090-2092	IN	denotes	of
T1641	2093-2106	JJ	denotes	TLR4-mediated
T1642	2107-2116	VBG	denotes	signaling
T1643	2117-2119	IN	denotes	in
T1644	2120-2123	NN	denotes	rat
T1645	2124-2129	NN	denotes	brain
T1646	2130-2136	NN	denotes	tissue
T1647	2137-2142	IN	denotes	after
T1648	2143-2146	NNP	denotes	ICH
T1649	2146-2147	.	denotes	.
T1989	2161-2164	CD	denotes	2.1
T1990	2164-2165	.	denotes	.
T1991	2166-2173	NNS	denotes	Animals
T1992	2174-2180	CD	denotes	Ninety
T1993	2181-2187	NNP	denotes	Wister
T1994	2188-2192	NNS	denotes	rats
T1995	2193-2194	-LRB-	denotes	(
T1996	2194-2198	NN	denotes	male
T1997	2198-2199	,	denotes	,
T1998	2200-2204	NN	denotes	body
T1999	2205-2211	NN	denotes	weight
T2000	2211-2212	:	denotes	:
T2001	2213-2216	CD	denotes	250
T2002	2217-2218	NN	denotes	g
T2003	2219-2221	TO	denotes	to
T2004	2222-2225	CD	denotes	300
T2005	2226-2227	NN	denotes	g
T2006	2227-2228	-RRB-	denotes	)
T2007	2229-2233	VBD	denotes	were
T2008	2234-2242	VBN	denotes	provided
T2009	2243-2245	IN	denotes	by
T2010	2246-2258	JJ	denotes	Experimental
T2011	2259-2265	NNP	denotes	Animal
T2012	2266-2272	NNP	denotes	Center
T2013	2272-2273	,	denotes	,
T2014	2274-2279	NNP	denotes	China
T2015	2280-2287	NNP	denotes	Medical
T2016	2288-2298	NNP	denotes	University
T2017	2298-2299	.	denotes	.
T2018	2300-2303	DT	denotes	The
T2019	2304-2308	NNS	denotes	rats
T2020	2309-2313	VBD	denotes	were
T2021	2314-2322	VBN	denotes	assigned
T2022	2323-2331	RB	denotes	randomly
T2023	2332-2334	TO	denotes	to
T2024	2335-2340	CD	denotes	three
T2025	2341-2347	NNS	denotes	groups
T2026	2347-2348	:	denotes	:
T2027	2349-2355	JJ	denotes	normal
T2028	2356-2361	NN	denotes	group
T2029	2362-2363	-LRB-	denotes	(
T2030	2363-2364	NNP	denotes	N
T2031	2364-2365	,	denotes	,
T2032	2366-2367	JJ	denotes	n
T2033	2368-2369	SYM	denotes	=
T2034	2370-2372	CD	denotes	10
T2035	2372-2373	,	denotes	,
T2036	2374-2381	IN	denotes	without
T2037	2382-2385	DT	denotes	any
T2038	2386-2395	NN	denotes	treatment
T2039	2395-2396	-RRB-	denotes	)
T2040	2396-2397	,	denotes	,
T2041	2398-2404	JJ	denotes	normal
T2042	2405-2411	NN	denotes	saline
T2043	2412-2419	NN	denotes	control
T2044	2420-2421	-LRB-	denotes	(
T2045	2421-2422	NNP	denotes	S
T2046	2422-2423	,	denotes	,
T2047	2424-2425	JJ	denotes	n
T2048	2426-2427	SYM	denotes	=
T2049	2428-2430	CD	denotes	40
T2050	2430-2431	,	denotes	,
T2051	2432-2446	JJ	denotes	intra-cerebral
T2052	2447-2456	NN	denotes	injection
T2053	2457-2459	IN	denotes	of
T2054	2460-2466	JJ	denotes	normal
T2055	2467-2473	NN	denotes	saline
T2056	2474-2476	IN	denotes	as
T2057	2477-2484	NN	denotes	control
T2058	2484-2485	-RRB-	denotes	)
T2059	2486-2489	CC	denotes	and
T2060	2490-2504	JJ	denotes	intra-cerebral
T2061	2505-2515	NN	denotes	hemorrhage
T2062	2516-2521	NN	denotes	group
T2063	2522-2523	-LRB-	denotes	(
T2064	2523-2526	NNP	denotes	ICH
T2065	2526-2527	,	denotes	,
T2066	2528-2529	JJ	denotes	n
T2067	2530-2531	SYM	denotes	=
T2068	2532-2534	CD	denotes	40
T2069	2534-2535	-RRB-	denotes	)
T2070	2535-2536	.	denotes	.
T2071	2537-2540	DT	denotes	The
T2072	2541-2553	JJ	denotes	experimental
T2073	2554-2562	NN	denotes	protocol
T2074	2563-2567	VBN	denotes	used
T2075	2568-2571	IN	denotes	for
T2076	2572-2579	NNS	denotes	animals
T2077	2580-2583	VBD	denotes	was
T2078	2584-2592	VBN	denotes	approved
T2079	2593-2595	IN	denotes	by
T2080	2596-2599	DT	denotes	the
T2081	2600-2606	NNP	denotes	Animal
T2082	2607-2611	NNP	denotes	Care
T2083	2612-2615	CC	denotes	and
T2084	2616-2619	NNP	denotes	Use
T2085	2620-2629	NNP	denotes	Committee
T2086	2629-2630	,	denotes	,
T2087	2631-2636	NNP	denotes	China
T2088	2637-2644	NNP	denotes	Medical
T2089	2645-2655	NNP	denotes	University
T2090	2655-2656	.	denotes	.
T2091	2657-2660	DT	denotes	The
T2092	2661-2665	NNS	denotes	rats
T2093	2666-2670	VBD	denotes	were
T2094	2671-2680	VBN	denotes	subjected
T2095	2681-2683	TO	denotes	to
T2096	2684-2698	JJ	denotes	intra-cerebral
T2097	2699-2708	NN	denotes	injection
T2098	2709-2711	IN	denotes	of
T2099	2712-2718	JJ	denotes	normal
T2100	2719-2725	NN	denotes	saline
T2101	2726-2728	CC	denotes	or
T2102	2729-2739	JJ	denotes	autologous
T2103	2740-2745	JJ	denotes	whole
T2104	2746-2751	NN	denotes	blood
T2105	2752-2755	CC	denotes	and
T2106	2756-2760	VBD	denotes	were
T2107	2761-2771	VBN	denotes	sacrificed
T2108	2772-2774	IN	denotes	on
T2109	2775-2776	CD	denotes	6
T2110	2777-2782	NNS	denotes	hours
T2111	2782-2783	,	denotes	,
T2112	2784-2785	CD	denotes	1
T2113	2786-2789	NN	denotes	day
T2114	2789-2790	,	denotes	,
T2115	2791-2792	CD	denotes	3
T2116	2793-2797	NNS	denotes	days
T2117	2798-2801	CC	denotes	and
T2118	2802-2803	CD	denotes	7
T2119	2804-2808	NNS	denotes	days
T2120	2809-2814	IN	denotes	after
T2121	2815-2818	DT	denotes	the
T2122	2819-2828	NN	denotes	injection
T2123	2828-2829	,	denotes	,
T2124	2830-2842	RB	denotes	respectively
T2125	2842-2843	.	denotes	.
T2126	2844-2848	CD	denotes	Five
T2127	2849-2853	NNS	denotes	rats
T2128	2854-2856	IN	denotes	in
T2129	2857-2861	DT	denotes	each
T2130	2862-2867	NN	denotes	group
T2131	2868-2870	IN	denotes	at
T2132	2871-2875	DT	denotes	each
T2133	2876-2880	NN	denotes	time
T2134	2881-2886	NN	denotes	point
T2135	2887-2891	VBD	denotes	were
T2136	2892-2902	VBN	denotes	sacrificed
T2137	2903-2905	IN	denotes	by
T2138	2906-2920	RB	denotes	transcardially
T2139	2921-2930	NN	denotes	perfusion
T2140	2931-2933	IN	denotes	of
T2141	2934-2940	JJ	denotes	normal
T2142	2941-2947	NN	denotes	saline
T2143	2948-2956	VBN	denotes	followed
T2144	2957-2959	IN	denotes	by
T2145	2960-2961	CD	denotes	4
T2146	2961-2962	NN	denotes	%
T2147	2963-2971	VBD	denotes	buffered
T2148	2972-2976	NNP	denotes	Para
T2149	2977-2989	NN	denotes	formaldehyde
T2150	2990-2991	-LRB-	denotes	(
T2151	2991-2993	NNP	denotes	pH
T2152	2994-2995	SYM	denotes	=
T2153	2996-2999	CD	denotes	7.4
T2154	2999-3000	-RRB-	denotes	)
T2155	3000-3001	.	denotes	.
T2156	3002-3005	DT	denotes	The
T2157	3006-3012	NNS	denotes	brains
T2158	3013-3017	VBD	denotes	were
T2159	3018-3025	VBN	denotes	removed
T2160	3025-3026	,	denotes	,
T2161	3027-3036	VBN	denotes	postfixed
T2162	3036-3037	,	denotes	,
T2163	3038-3046	VBN	denotes	embedded
T2164	3047-3049	IN	denotes	in
T2165	3050-3058	NN	denotes	paraffin
T2166	3058-3059	,	denotes	,
T2167	3060-3063	CC	denotes	and
T2168	3064-3067	VBD	denotes	cut
T2169	3068-3072	IN	denotes	into
T2170	3073-3081	NNS	denotes	sections
T2171	3082-3083	-LRB-	denotes	(
T2172	3083-3084	CD	denotes	7
T2173	3085-3087	NN	denotes	μm
T2174	3087-3088	-RRB-	denotes	)
T2175	3089-3091	IN	denotes	as
T2176	3092-3101	VBN	denotes	described
T2177	3102-3112	RB	denotes	previously
T2178	3113-3114	JJ	denotes	[
T2179	3114-3115	CD	denotes	8
T2180	3115-3116	NN	denotes	]
T2181	3116-3117	.	denotes	.
T2182	3118-3122	CD	denotes	Five
T2183	3123-3127	NNS	denotes	rats
T2184	3128-3130	IN	denotes	in
T2185	3131-3135	DT	denotes	each
T2186	3136-3141	NN	denotes	group
T2187	3142-3144	IN	denotes	at
T2188	3145-3149	DT	denotes	each
T2189	3150-3154	NN	denotes	time
T2190	3155-3160	NN	denotes	point
T2191	3161-3165	VBD	denotes	were
T2192	3166-3176	VBN	denotes	sacrificed
T2193	3177-3179	IN	denotes	by
T2194	3180-3184	IN	denotes	over
T2195	3185-3189	NN	denotes	dose
T2196	3190-3199	NN	denotes	injection
T2197	3200-3202	IN	denotes	of
T2198	3203-3211	NNP	denotes	Ketamine
T2199	3211-3212	.	denotes	.
T2200	3213-3216	DT	denotes	The
T2201	3217-3223	NNS	denotes	brains
T2202	3224-3228	VBD	denotes	were
T2203	3229-3236	VBN	denotes	removed
T2204	3237-3240	CC	denotes	and
T2205	3241-3247	VBN	denotes	stored
T2206	3248-3250	IN	denotes	at
T2207	3251-3256	CC	denotes	minus
T2208	3257-3259	CD	denotes	80
T2209	3259-3260	CD	denotes	°
T2210	3260-3261	NNP	denotes	C
T2211	3262-3265	IN	denotes	for
T2212	3266-3272	NNP	denotes	RT-PCR
T2213	3273-3276	CC	denotes	and
T2214	3277-3284	NNP	denotes	Western
T2215	3285-3290	NNP	denotes	Blots
T2216	3290-3291	.	denotes	.
T2449	3293-3296	CD	denotes	2.2
T2450	3296-3297	.	denotes	.
T2451	3298-3307	NNP	denotes	Induction
T2452	3308-3310	IN	denotes	of
T2453	3311-3324	NNP	denotes	Intracerebral
T2454	3325-3335	NNP	denotes	Hemorrhage
T2455	3336-3341	IN	denotes	Since
T2456	3342-3346	JJS	denotes	most
T2457	3347-3360	JJ	denotes	intracerebral
T2458	3361-3372	NNS	denotes	hemorrhages
T2459	3373-3378	VBP	denotes	occur
T2460	3379-3381	IN	denotes	in
T2461	3382-3385	DT	denotes	the
T2462	3386-3391	JJ	denotes	basal
T2463	3392-3399	NN	denotes	ganglia
T2464	3400-3410	RB	denotes	clinically
T2465	3410-3411	,	denotes	,
T2466	3412-3414	IN	denotes	in
T2467	3415-3418	DT	denotes	the
T2468	3419-3426	JJ	denotes	present
T2469	3427-3432	NN	denotes	study
T2470	3432-3433	,	denotes	,
T2471	3434-3437	NN	denotes	rat
T2472	3438-3443	NN	denotes	model
T2473	3444-3446	IN	denotes	of
T2474	3447-3450	NNP	denotes	ICH
T2475	3451-3454	VBD	denotes	was
T2476	3455-3462	VBN	denotes	induced
T2477	3463-3465	IN	denotes	in
T2478	3466-3470	JJ	denotes	left
T2479	3471-3476	JJ	denotes	basal
T2480	3477-3484	NNS	denotes	ganglia
T2481	3484-3485	.	denotes	.
T2482	3486-3490	NNS	denotes	Rats
T2483	3491-3495	VBD	denotes	were
T2484	3496-3508	JJ	denotes	anesthetized
T2485	3509-3513	IN	denotes	with
T2486	3514-3530	JJ	denotes	intra-peritoneal
T2487	3531-3537	NN	denotes	sodium
T2488	3538-3551	JJ	denotes	pentobarbital
T2489	3552-3553	-LRB-	denotes	(
T2490	3553-3555	CD	denotes	60
T2491	3556-3561	NN	denotes	mg/kg
T2492	3561-3562	-RRB-	denotes	)
T2493	3562-3563	.	denotes	.
T2494	3564-3567	DT	denotes	The
T2495	3568-3572	NN	denotes	body
T2496	3573-3574	-LRB-	denotes	(
T2497	3574-3580	JJ	denotes	rectal
T2498	3580-3581	-RRB-	denotes	)
T2499	3582-3593	NN	denotes	temperature
T2500	3594-3597	VBD	denotes	was
T2501	3598-3608	VBN	denotes	maintained
T2502	3609-3611	IN	denotes	at
T2503	3612-3614	CD	denotes	37
T2504	3614-3615	CD	denotes	°
T2505	3615-3616	NNP	denotes	C
T2506	3617-3623	IN	denotes	during
T2507	3624-3627	DT	denotes	the
T2508	3628-3635	NN	denotes	surgery
T2509	3636-3641	VBG	denotes	using
T2510	3642-3643	DT	denotes	a
T2511	3644-3663	JJ	denotes	feedback-controlled
T2512	3664-3671	NN	denotes	heating
T2513	3672-3678	NN	denotes	system
T2514	3678-3679	.	denotes	.
T2515	3680-3683	DT	denotes	The
T2516	3684-3688	NNS	denotes	rats
T2517	3689-3693	VBD	denotes	were
T2518	3694-3704	VBN	denotes	positioned
T2519	3705-3707	IN	denotes	in
T2520	3708-3709	DT	denotes	a
T2521	3710-3722	JJ	denotes	stereotactic
T2522	3723-3728	NN	denotes	frame
T2523	3728-3729	,	denotes	,
T2524	3730-3733	CC	denotes	and
T2525	3734-3737	DT	denotes	the
T2526	3738-3743	NN	denotes	scalp
T2527	3744-3747	VBD	denotes	was
T2528	3748-3755	VBN	denotes	incised
T2529	3756-3761	IN	denotes	along
T2530	3762-3765	DT	denotes	the
T2531	3766-3773	NN	denotes	midline
T2532	3773-3774	.	denotes	.
T2533	3775-3780	VBG	denotes	Using
T2534	3781-3782	DT	denotes	a
T2535	3783-3790	JJ	denotes	sterile
T2536	3791-3800	NN	denotes	technique
T2537	3800-3801	,	denotes	,
T2538	3802-3803	DT	denotes	a
T2539	3804-3805	CD	denotes	1
T2540	3806-3808	NN	denotes	mm
T2541	3809-3813	NN	denotes	burr
T2542	3814-3818	NN	denotes	hole
T2543	3819-3822	VBD	denotes	was
T2544	3823-3829	VBN	denotes	opened
T2545	3830-3832	IN	denotes	in
T2546	3833-3836	DT	denotes	the
T2547	3837-3842	NN	denotes	skull
T2548	3843-3845	IN	denotes	on
T2549	3846-3849	DT	denotes	the
T2550	3850-3854	VBN	denotes	left
T2551	3855-3862	JJ	denotes	coronal
T2552	3863-3869	NN	denotes	suture
T2553	3870-3871	CD	denotes	3
T2554	3872-3874	NN	denotes	mm
T2555	3875-3882	NN	denotes	lateral
T2556	3883-3885	TO	denotes	to
T2557	3886-3889	DT	denotes	the
T2558	3890-3897	NN	denotes	midline
T2559	3897-3898	.	denotes	.
T2560	3899-3900	DT	denotes	A
T2561	3901-3906	JJ	denotes	blunt
T2562	3907-3915	JJ	denotes	26-gauge
T2563	3916-3922	NN	denotes	needle
T2564	3923-3926	VBD	denotes	was
T2565	3927-3935	VBN	denotes	inserted
T2566	3936-3940	IN	denotes	into
T2567	3941-3944	DT	denotes	the
T2568	3945-3949	JJ	denotes	left
T2569	3950-3955	JJ	denotes	basal
T2570	3956-3963	NN	denotes	ganglia
T2571	3964-3969	IN	denotes	under
T2572	3970-3982	JJ	denotes	stereotactic
T2573	3983-3991	NN	denotes	guidance
T2574	3992-3993	-LRB-	denotes	(
T2575	3993-4004	VBZ	denotes	coordinates
T2576	4004-4005	:	denotes	:
T2577	4006-4009	CD	denotes	0.2
T2578	4010-4012	NN	denotes	mm
T2579	4013-4021	NN	denotes	anterior
T2580	4021-4022	,	denotes	,
T2581	4023-4026	CD	denotes	6.0
T2582	4027-4029	NN	denotes	mm
T2583	4030-4037	NN	denotes	ventral
T2584	4037-4038	,	denotes	,
T2585	4039-4042	CC	denotes	and
T2586	4043-4046	CD	denotes	3.0
T2587	4047-4049	NN	denotes	mm
T2588	4050-4057	NN	denotes	lateral
T2589	4058-4060	TO	denotes	to
T2590	4061-4064	DT	denotes	the
T2591	4065-4072	NN	denotes	midline
T2592	4072-4073	-RRB-	denotes	)
T2593	4073-4074	.	denotes	.
T2594	4075-4079	RB	denotes	Then
T2595	4079-4080	,	denotes	,
T2596	4081-4082	DT	denotes	a
T2597	4083-4085	CD	denotes	75
T2598	4086-4088	NN	denotes	μL
T2599	4089-4091	IN	denotes	of
T2600	4092-4102	JJ	denotes	autologous
T2601	4103-4108	JJ	denotes	whole
T2602	4109-4114	NN	denotes	blood
T2603	4115-4118	VBD	denotes	was
T2604	4119-4126	VBN	denotes	infused
T2605	4127-4129	IN	denotes	at
T2606	4130-4131	DT	denotes	a
T2607	4132-4136	NN	denotes	rate
T2608	4137-4139	IN	denotes	of
T2609	4140-4142	CD	denotes	20
T2610	4143-4145	NNP	denotes	μL
T2611	4145-4146	NNP	denotes	/
T2612	4146-4149	NN	denotes	min
T2613	4150-4154	IN	denotes	with
T2614	4155-4158	DT	denotes	the
T2615	4159-4162	NN	denotes	use
T2616	4163-4165	IN	denotes	of
T2617	4166-4167	DT	denotes	a
T2618	4168-4181	NN	denotes	microinfusion
T2619	4182-4186	NN	denotes	pump
T2620	4186-4187	.	denotes	.
T2621	4188-4193	IN	denotes	After
T2622	4194-4197	DT	denotes	the
T2623	4198-4208	NN	denotes	completion
T2624	4209-4211	IN	denotes	of
T2625	4212-4215	DT	denotes	the
T2626	4216-4224	NN	denotes	infusion
T2627	4224-4225	,	denotes	,
T2628	4226-4229	DT	denotes	the
T2629	4230-4236	NN	denotes	needle
T2630	4237-4240	VBD	denotes	was
T2631	4241-4250	VBN	denotes	withdrawn
T2632	4251-4258	RB	denotes	quickly
T2633	4258-4259	,	denotes	,
T2634	4260-4273	VBP	denotes	cyanoacrylate
T2635	4274-4278	NN	denotes	glue
T2636	4279-4282	VBD	denotes	was
T2637	4283-4289	VBN	denotes	placed
T2638	4290-4296	IN	denotes	around
T2639	4297-4300	DT	denotes	the
T2640	4301-4305	NN	denotes	burr
T2641	4306-4310	NN	denotes	hole
T2642	4310-4311	,	denotes	,
T2643	4312-4315	CC	denotes	and
T2644	4316-4319	DT	denotes	the
T2645	4320-4324	NN	denotes	skin
T2646	4325-4333	NN	denotes	incision
T2647	4334-4337	VBD	denotes	was
T2648	4338-4344	VBN	denotes	closed
T2649	4345-4349	IN	denotes	with
T2650	4350-4357	NNS	denotes	sutures
T2651	4357-4358	.	denotes	.
T2652	4359-4362	IN	denotes	For
T2653	4363-4366	DT	denotes	the
T2654	4367-4373	JJ	denotes	normal
T2655	4374-4380	NN	denotes	saline
T2656	4381-4388	NN	denotes	control
T2657	4389-4393	NNS	denotes	rats
T2658	4393-4394	,	denotes	,
T2659	4395-4399	RB	denotes	only
T2660	4400-4402	CD	denotes	75
T2661	4403-4405	NN	denotes	μL
T2662	4406-4412	JJ	denotes	normal
T2663	4413-4419	NN	denotes	saline
T2664	4420-4423	VBD	denotes	was
T2665	4424-4432	VBN	denotes	injected
T2666	4432-4433	.	denotes	.
T3069	4435-4438	CD	denotes	2.3
T3070	4438-4439	.	denotes	.
T3071	4440-4449	NNP	denotes	Detection
T3072	4450-4452	IN	denotes	of
T3073	4453-4457	NNP	denotes	TLR4
T3074	4458-4462	NNP	denotes	mRNA
T3075	4463-4465	IN	denotes	by
T3076	4466-4469	DT	denotes	the
T3077	4470-4476	NNP	denotes	Method
T3078	4477-4479	IN	denotes	of
T3079	4480-4486	NNP	denotes	RT-PCR
T3080	4487-4494	NNP	denotes	Briefly
T3081	4494-4495	,	denotes	,
T3082	4496-4501	JJ	denotes	total
T3083	4502-4505	NNP	denotes	RNA
T3084	4506-4513	NNS	denotes	samples
T3085	4514-4518	VBD	denotes	were
T3086	4519-4527	VBN	denotes	isolated
T3087	4528-4532	IN	denotes	from
T3088	4533-4548	JJ	denotes	peri-hemorrhage
T3089	4549-4556	NNS	denotes	regions
T3090	4557-4559	IN	denotes	in
T3091	4560-4564	JJ	denotes	left
T3092	4565-4570	JJ	denotes	basal
T3093	4571-4578	NN	denotes	ganglia
T3094	4579-4584	VBG	denotes	using
T3095	4585-4591	RB	denotes	Simply
T3096	4592-4593	NNP	denotes	P
T3097	4594-4599	NNP	denotes	Total
T3098	4600-4603	NNP	denotes	RNA
T3099	4604-4613	NN	denotes	isolation
T3100	4614-4617	NN	denotes	Kit
T3101	4618-4619	-LRB-	denotes	(
T3102	4619-4626	NNP	denotes	BioFlux
T3103	4626-4627	,	denotes	,
T3104	4628-4630	NNP	denotes	HZ
T3105	4630-4631	,	denotes	,
T3106	4632-4637	NNP	denotes	China
T3107	4637-4638	-RRB-	denotes	)
T3108	4639-4648	VBG	denotes	according
T3109	4649-4651	TO	denotes	to
T3110	4652-4655	DT	denotes	the
T3111	4656-4668	NN	denotes	manufacturer
T3112	4668-4670	POS	denotes	's
T3113	4671-4683	NNS	denotes	instructions
T3114	4683-4684	.	denotes	.
T3115	4685-4688	DT	denotes	The
T3116	4689-4697	NN	denotes	quantity
T3117	4698-4700	IN	denotes	of
T3118	4701-4706	JJ	denotes	total
T3119	4707-4710	NNP	denotes	RNA
T3120	4711-4714	VBD	denotes	was
T3121	4715-4725	VBN	denotes	determined
T3122	4726-4728	IN	denotes	on
T3123	4729-4730	DT	denotes	a
T3124	4731-4739	NNP	denotes	Nanodrop
T3125	4740-4741	-LRB-	denotes	(
T3126	4741-4748	NNP	denotes	ND-1000
T3127	4749-4766	NNP	denotes	Spectrophotometer
T3128	4766-4767	-RRB-	denotes	)
T3129	4768-4770	IN	denotes	by
T3130	4771-4780	VBG	denotes	measuring
T3131	4781-4788	JJ	denotes	optical
T3132	4789-4796	NN	denotes	density
T3133	4797-4799	IN	denotes	at
T3134	4800-4804	CD	denotes	A260
T3135	4805-4808	CC	denotes	and
T3136	4809-4813	CD	denotes	A280
T3137	4814-4816	NN	denotes	nm
T3138	4817-4827	NN	denotes	wavelength
T3139	4827-4828	.	denotes	.
T3140	4829-4833	RB	denotes	Then
T3141	4833-4834	,	denotes	,
T3142	4835-4838	DT	denotes	the
T3143	4839-4853	NNS	denotes	concentrations
T3144	4854-4856	IN	denotes	of
T3145	4857-4861	NNP	denotes	mRNA
T3146	4862-4866	VBD	denotes	were
T3147	4867-4875	VBN	denotes	adjusted
T3148	4876-4878	TO	denotes	to
T3149	4879-4882	CD	denotes	1.0
T3150	4883-4887	NNP	denotes	g/mL
T3151	4887-4888	.	denotes	.
T3152	4889-4892	NNP	denotes	RNA
T3153	4893-4896	VBD	denotes	was
T3154	4897-4916	VBN	denotes	reverse-transcribed
T3155	4917-4921	IN	denotes	into
T3156	4922-4926	NNP	denotes	cDNA
T3157	4927-4929	IN	denotes	in
T3158	4930-4932	CD	denotes	20
T3159	4933-4935	NN	denotes	μL
T3160	4936-4944	NN	denotes	reaction
T3161	4945-4951	NN	denotes	system
T3162	4952-4957	VBG	denotes	using
T3163	4958-4969	NNP	denotes	Superscript
T3164	4970-4982	NNP	denotes	First-Strand
T3165	4983-4992	NNP	denotes	Synthesis
T3166	4993-4996	NNP	denotes	Kit
T3167	4997-5000	IN	denotes	for
T3168	5001-5007	NNP	denotes	RT-PCR
T3169	5008-5009	-LRB-	denotes	(
T3170	5009-5016	JJ	denotes	promega
T3171	5017-5020	NNP	denotes	Inc
T3172	5020-5021	-RRB-	denotes	)
T3173	5022-5027	IN	denotes	under
T3174	5028-5038	NNS	denotes	conditions
T3175	5039-5048	VBN	denotes	described
T3176	5049-5051	IN	denotes	by
T3177	5052-5055	DT	denotes	the
T3178	5056-5064	NN	denotes	supplier
T3179	5064-5065	.	denotes	.
T3180	5066-5069	CD	denotes	One
T3181	5070-5080	NN	denotes	microliter
T3182	5081-5083	IN	denotes	of
T3183	5084-5088	NNP	denotes	cDNA
T3184	5089-5092	VBD	denotes	was
T3185	5093-5097	VBN	denotes	used
T3186	5098-5100	TO	denotes	to
T3187	5101-5108	VB	denotes	amplify
T3188	5109-5112	DT	denotes	the
T3189	5113-5117	CD	denotes	TLR4
T3190	5118-5122	NN	denotes	gene
T3191	5123-5131	NN	denotes	fragment
T3192	5132-5136	IN	denotes	with
T3193	5137-5138	CD	denotes	1
T3194	5138-5139	CD	denotes	×
T3195	5140-5143	NNP	denotes	PCR
T3196	5144-5150	NN	denotes	buffer
T3197	5150-5151	,	denotes	,
T3198	5152-5155	CD	denotes	1.5
T3199	5156-5158	NNP	denotes	mM
T3200	5159-5164	NNP	denotes	MgCl2
T3201	5164-5165	,	denotes	,
T3202	5166-5169	CD	denotes	200
T3203	5170-5172	NN	denotes	μM
T3204	5173-5175	IN	denotes	of
T3205	5176-5180	DT	denotes	each
T3206	5181-5185	NNP	denotes	dNTP
T3207	5185-5186	,	denotes	,
T3208	5187-5190	CD	denotes	200
T3209	5191-5193	NN	denotes	μM
T3210	5194-5196	IN	denotes	of
T3211	5197-5204	NNS	denotes	primers
T3212	5204-5205	,	denotes	,
T3213	5206-5209	CC	denotes	and
T3214	5210-5212	CD	denotes	2u
T3215	5213-5216	NNP	denotes	Taq
T3216	5217-5220	NNP	denotes	DNA
T3217	5221-5231	NN	denotes	polymerase
T3218	5231-5232	.	denotes	.
T3219	5233-5236	DT	denotes	The
T3220	5237-5242	NN	denotes	house
T3221	5243-5247	VB	denotes	keep
T3222	5248-5252	NN	denotes	gene
T3223	5253-5254	-LRB-	denotes	(
T3224	5254-5261	NN	denotes	β-actin
T3225	5261-5262	-RRB-	denotes	)
T3226	5263-5266	VBD	denotes	was
T3227	5267-5271	VBN	denotes	used
T3228	5272-5274	IN	denotes	as
T3229	5275-5277	DT	denotes	an
T3230	5278-5286	JJ	denotes	internal
T3231	5287-5294	NN	denotes	control
T3232	5294-5295	.	denotes	.
T3233	5296-5299	DT	denotes	The
T3234	5300-5303	NNP	denotes	PCR
T3235	5304-5310	NN	denotes	primer
T3236	5311-5320	NNS	denotes	sequences
T3237	5321-5325	VBD	denotes	were
T3238	5326-5334	VBN	denotes	designed
T3239	5335-5344	VBG	denotes	according
T3240	5345-5347	TO	denotes	to
T3241	5348-5351	DT	denotes	the
T3242	5352-5356	CD	denotes	TLR4
T3243	5357-5360	CC	denotes	and
T3244	5361-5368	JJ	denotes	β-actin
T3245	5369-5373	NN	denotes	gene
T3246	5374-5383	NNS	denotes	sequences
T3247	5384-5392	VBD	denotes	reported
T3248	5393-5395	IN	denotes	in
T3249	5396-5403	NNP	denotes	GenBank
T3250	5403-5404	.	denotes	.
T3251	5405-5409	CD	denotes	TLR4
T3252	5410-5411	-LRB-	denotes	(
T3253	5411-5414	CD	denotes	145
T3254	5415-5417	NN	denotes	bp
T3255	5417-5418	-RRB-	denotes	)
T3256	5418-5419	:	denotes	:
T3257	5420-5427	RB	denotes	forward
T3258	5427-5428	:	denotes	:
T3259	5429-5430	CD	denotes	5
T3260	5430-5431	SYM	denotes	′
T3261	5431-5432	:	denotes	-
T3262	5432-5454	NN	denotes	AGCTTTGGTCAGTTGGCTCT-3
T3263	5454-5455	NN	denotes	′
T3264	5455-5456	:	denotes	;
T3265	5457-5464	NN	denotes	reverse
T3266	5464-5465	:	denotes	:
T3267	5466-5467	CD	denotes	5
T3268	5467-5468	SYM	denotes	′
T3269	5468-5469	:	denotes	-
T3270	5469-5491	NN	denotes	CAGGATGACACCATTGAAGC-3
T3271	5491-5492	NN	denotes	′
T3272	5492-5493	:	denotes	;
T3273	5494-5501	NN	denotes	β-actin
T3274	5502-5503	-LRB-	denotes	(
T3275	5503-5506	CD	denotes	701
T3276	5507-5509	NN	denotes	bp
T3277	5509-5510	-RRB-	denotes	)
T3278	5510-5511	:	denotes	:
T3279	5512-5519	RB	denotes	forward
T3280	5519-5520	:	denotes	:
T3281	5521-5522	CD	denotes	5
T3282	5522-5523	SYM	denotes	′
T3283	5523-5524	:	denotes	-
T3284	5524-5545	NN	denotes	GCCAACCGTGAAAAAGATG-3
T3285	5545-5546	NN	denotes	′
T3286	5546-5547	:	denotes	;
T3287	5548-5555	NN	denotes	reverse
T3288	5555-5556	:	denotes	:
T3289	5557-5558	CD	denotes	5
T3290	5558-5559	SYM	denotes	′
T3291	5559-5560	:	denotes	-
T3292	5560-5581	NN	denotes	CCAGGATAGAGCCACCAAT-3
T3293	5581-5582	NN	denotes	′
T3294	5582-5583	.	denotes	.
T3295	5584-5592	NN	denotes	Reaction
T3296	5593-5599	NNS	denotes	cycles
T3297	5600-5604	VBD	denotes	were
T3298	5605-5614	VBN	denotes	performed
T3299	5615-5617	IN	denotes	at
T3300	5618-5621	DT	denotes	the
T3301	5622-5631	JJ	denotes	following
T3302	5632-5641	NN	denotes	condition
T3303	5641-5642	:	denotes	:
T3304	5643-5645	CD	denotes	94
T3305	5645-5646	NN	denotes	°
T3306	5646-5647	NNP	denotes	C
T3307	5648-5649	CD	denotes	2
T3308	5650-5653	NN	denotes	min
T3309	5653-5654	,	denotes	,
T3310	5655-5657	CD	denotes	94
T3311	5657-5658	NN	denotes	°
T3312	5658-5659	NNP	denotes	C
T3313	5660-5662	CD	denotes	40
T3314	5663-5664	PRP	denotes	s
T3315	5664-5665	,	denotes	,
T3316	5666-5668	CD	denotes	55
T3317	5668-5669	NN	denotes	°
T3318	5669-5670	NNP	denotes	C
T3319	5671-5673	CD	denotes	40
T3320	5674-5675	PRP	denotes	s
T3321	5675-5676	,	denotes	,
T3322	5677-5680	CC	denotes	and
T3323	5681-5683	CD	denotes	72
T3324	5683-5684	NN	denotes	°
T3325	5684-5685	NNP	denotes	C
T3326	5686-5688	CD	denotes	60
T3327	5689-5690	PRP	denotes	s
T3328	5690-5691	.	denotes	.
T3329	5692-5695	DT	denotes	The
T3330	5696-5704	NN	denotes	reaction
T3331	5705-5708	VBD	denotes	was
T3332	5709-5716	VBN	denotes	stopped
T3333	5717-5722	RB	denotes	after
T3334	5723-5725	CD	denotes	31
T3335	5726-5732	NNS	denotes	cycles
T3336	5732-5733	.	denotes	.
T3337	5734-5737	NNP	denotes	PCR
T3338	5738-5746	NNS	denotes	products
T3339	5747-5751	VBD	denotes	were
T3340	5752-5767	VBN	denotes	electrophoresed
T3341	5768-5775	IN	denotes	through
T3342	5776-5783	JJ	denotes	agarose
T3343	5784-5787	NN	denotes	gel
T3344	5787-5788	.	denotes	.
T3345	5789-5794	NN	denotes	Image
T3346	5795-5806	NNP	denotes	Acquisition
T3347	5807-5810	CC	denotes	and
T3348	5811-5819	NNP	denotes	Analysis
T3349	5820-5828	NN	denotes	software
T3350	5829-5833	VBD	denotes	were
T3351	5834-5838	VBN	denotes	used
T3352	5839-5841	TO	denotes	to
T3353	5842-5851	VB	denotes	determine
T3354	5852-5856	NN	denotes	band
T3355	5857-5866	NNS	denotes	densities
T3356	5866-5867	.	denotes	.
T3357	5868-5871	DT	denotes	The
T3358	5872-5881	NN	denotes	abundance
T3359	5882-5884	IN	denotes	of
T3360	5885-5889	CD	denotes	TLR4
T3361	5890-5894	NNP	denotes	mRNA
T3362	5895-5898	VBD	denotes	was
T3363	5899-5908	VBN	denotes	expressed
T3364	5909-5911	IN	denotes	as
T3365	5912-5915	DT	denotes	the
T3366	5916-5921	NN	denotes	ratio
T3367	5922-5924	IN	denotes	of
T3368	5925-5929	CD	denotes	TLR4
T3369	5930-5934	NNP	denotes	mRNA
T3370	5935-5937	TO	denotes	to
T3371	5938-5945	VB	denotes	β-actin
T3372	5946-5950	NNP	denotes	mRNA
T3373	5950-5951	.	denotes	.
T3606	5953-5956	CD	denotes	2.4
T3607	5956-5957	.	denotes	.
T3608	5958-5978	NNP	denotes	Immunohistochemistry
T3609	5979-5980	-LRB-	denotes	(
T3610	5980-5983	NNP	denotes	IHC
T3611	5983-5984	-RRB-	denotes	)
T3612	5985-5988	DT	denotes	The
T3613	5989-5992	NNP	denotes	IHC
T3614	5993-6001	VBG	denotes	staining
T3615	6002-6005	IN	denotes	for
T3616	6006-6010	CD	denotes	TLR4
T3617	6011-6014	VBD	denotes	was
T3618	6015-6024	VBN	denotes	performed
T3619	6025-6027	IN	denotes	as
T3620	6028-6037	VBN	denotes	described
T3621	6038-6048	RB	denotes	previously
T3622	6049-6050	JJ	denotes	[
T3623	6050-6051	CD	denotes	8
T3624	6051-6052	NN	denotes	]
T3625	6052-6053	.	denotes	.
T3626	6054-6057	DT	denotes	The
T3627	6058-6065	JJ	denotes	primary
T3628	6066-6074	NN	denotes	antibody
T3629	6075-6083	VBN	denotes	employed
T3630	6084-6087	VBD	denotes	was
T3631	6088-6094	NN	denotes	rabbit
T3632	6095-6104	NN	denotes	anti-TLR4
T3633	6105-6106	-LRB-	denotes	(
T3634	6106-6111	JJ	denotes	WuHan
T3635	6111-6112	,	denotes	,
T3636	6113-6119	NNP	denotes	BA1717
T3637	6119-6120	-RRB-	denotes	)
T3638	6120-6121	.	denotes	.
T3639	6122-6125	DT	denotes	The
T3640	6126-6138	JJ	denotes	biotinylated
T3641	6139-6148	JJ	denotes	secondary
T3642	6149-6157	NN	denotes	antibody
T3643	6158-6161	CC	denotes	and
T3644	6162-6195	JJ	denotes	antibody-biotin-avidin-peroxidase
T3645	6196-6205	NNS	denotes	complexes
T3646	6206-6207	-LRB-	denotes	(
T3647	6207-6210	NNP	denotes	ABC
T3648	6211-6218	NN	denotes	reagent
T3649	6218-6219	,	denotes	,
T3650	6220-6227	NN	denotes	SC-2018
T3651	6227-6228	-RRB-	denotes	)
T3652	6229-6233	VBD	denotes	were
T3653	6234-6242	VBN	denotes	obtained
T3654	6243-6247	IN	denotes	from
T3655	6248-6253	NNP	denotes	Santa
T3656	6254-6258	NNP	denotes	Cruz
T3657	6259-6272	NNP	denotes	Biotechnology
T3658	6273-6277	NNP	denotes	Inc.
T3659	6278-6279	-LRB-	denotes	(
T3660	6279-6284	NNP	denotes	Santa
T3661	6285-6289	NNP	denotes	Cruz
T3662	6289-6290	,	denotes	,
T3663	6291-6293	NNP	denotes	CA
T3664	6293-6294	-RRB-	denotes	)
T3665	6294-6295	.	denotes	.
T3666	6296-6302	NNS	denotes	Slides
T3667	6303-6312	VBN	denotes	processed
T3668	6313-6320	IN	denotes	without
T3669	6321-6328	JJ	denotes	primary
T3670	6329-6339	NNS	denotes	antibodies
T3671	6340-6346	VBD	denotes	served
T3672	6347-6349	IN	denotes	as
T3673	6350-6358	JJ	denotes	negative
T3674	6359-6367	NNS	denotes	controls
T3675	6367-6368	.	denotes	.
T3848	6370-6373	CD	denotes	2.5
T3849	6373-6374	.	denotes	.
T3850	6375-6382	JJ	denotes	Western
T3851	6383-6388	NNP	denotes	Blots
T3852	6389-6397	NNP	denotes	Cellular
T3853	6398-6406	NNS	denotes	proteins
T3854	6407-6411	VBD	denotes	were
T3855	6412-6420	VBN	denotes	prepared
T3856	6421-6425	IN	denotes	from
T3857	6426-6429	NNP	denotes	ICH
T3858	6430-6438	JJ	denotes	cerebral
T3859	6439-6450	NNS	denotes	hemispheres
T3860	6450-6451	,	denotes	,
T3861	6452-6467	VBN	denotes	electrophoresed
T3862	6468-6472	IN	denotes	with
T3863	6473-6491	JJ	denotes	SDS-polyacrylamide
T3864	6492-6495	NN	denotes	gel
T3865	6496-6499	CC	denotes	and
T3866	6500-6511	VBN	denotes	transferred
T3867	6512-6516	IN	denotes	onto
T3868	6517-6523	NNP	denotes	Hybond
T3869	6524-6527	NNP	denotes	ECL
T3870	6528-6537	NNS	denotes	membranes
T3871	6538-6539	-LRB-	denotes	(
T3872	6539-6547	NNP	denotes	Amersham
T3873	6548-6557	NNP	denotes	Pharmacia
T3874	6557-6558	,	denotes	,
T3875	6559-6569	NNP	denotes	Piscataway
T3876	6569-6570	,	denotes	,
T3877	6571-6573	NNP	denotes	NJ
T3878	6573-6574	-RRB-	denotes	)
T3879	6574-6575	.	denotes	.
T3880	6576-6579	DT	denotes	The
T3881	6580-6583	NNP	denotes	ECL
T3882	6584-6593	NNS	denotes	membranes
T3883	6594-6598	VBD	denotes	were
T3884	6599-6608	VBN	denotes	incubated
T3885	6609-6613	IN	denotes	with
T3886	6614-6617	DT	denotes	the
T3887	6618-6629	JJ	denotes	appropriate
T3888	6630-6637	JJ	denotes	primary
T3889	6638-6646	NN	denotes	antibody
T3890	6647-6648	-LRB-	denotes	(
T3891	6648-6653	JJ	denotes	WuHan
T3892	6653-6654	,	denotes	,
T3893	6655-6661	NNP	denotes	BA1717
T3894	6661-6662	-RRB-	denotes	)
T3895	6663-6671	VBN	denotes	followed
T3896	6672-6674	IN	denotes	by
T3897	6675-6685	NN	denotes	incubation
T3898	6686-6690	IN	denotes	with
T3899	6691-6712	JJ	denotes	peroxidase-conjugated
T3900	6713-6722	JJ	denotes	secondary
T3901	6723-6733	NNS	denotes	antibodies
T3902	6734-6735	-LRB-	denotes	(
T3903	6735-6741	NNP	denotes	Golden
T3904	6742-6748	NNP	denotes	Bridge
T3905	6748-6749	,	denotes	,
T3906	6750-6757	NNP	denotes	PV-6001
T3907	6757-6758	-RRB-	denotes	)
T3908	6758-6759	.	denotes	.
T3909	6760-6763	DT	denotes	The
T3910	6764-6771	NNS	denotes	signals
T3911	6772-6776	VBD	denotes	were
T3912	6777-6785	VBN	denotes	detected
T3913	6786-6790	IN	denotes	with
T3914	6791-6794	DT	denotes	the
T3915	6795-6798	NNP	denotes	ECL
T3916	6799-6805	NN	denotes	system
T3917	6806-6807	-LRB-	denotes	(
T3918	6807-6815	NNP	denotes	Amersham
T3919	6816-6825	NNP	denotes	Pharmacia
T3920	6825-6826	-RRB-	denotes	)
T3921	6826-6827	.	denotes	.
T3922	6828-6831	DT	denotes	The
T3923	6832-6836	JJ	denotes	same
T3924	6837-6846	NNS	denotes	membranes
T3925	6847-6851	VBD	denotes	were
T3926	6852-6858	VBN	denotes	probed
T3927	6859-6863	IN	denotes	with
T3928	6864-6874	JJ	denotes	anti-GAPDH
T3929	6875-6876	-LRB-	denotes	(
T3930	6876-6902	JJ	denotes	glyceraldehyde-3-phosphate
T3931	6903-6916	NN	denotes	dehydrogenase
T3932	6916-6917	,	denotes	,
T3933	6918-6927	NNP	denotes	Biodesign
T3934	6927-6928	,	denotes	,
T3935	6929-6933	NNP	denotes	Saco
T3936	6933-6934	,	denotes	,
T3937	6935-6940	NNP	denotes	Maine
T3938	6940-6941	-RRB-	denotes	)
T3939	6942-6947	IN	denotes	after
T3940	6948-6953	VBG	denotes	being
T3941	6954-6960	VBN	denotes	washed
T3942	6961-6965	IN	denotes	with
T3943	6966-6975	VBG	denotes	stripping
T3944	6976-6982	NN	denotes	buffer
T3945	6982-6983	.	denotes	.
T3946	6984-6987	DT	denotes	The
T3947	6988-6995	NNS	denotes	signals
T3948	6996-7000	VBD	denotes	were
T3949	7001-7011	VBN	denotes	quantified
T3950	7012-7014	IN	denotes	by
T3951	7015-7023	VBG	denotes	scanning
T3952	7024-7036	NN	denotes	densitometry
T3953	7037-7040	CC	denotes	and
T3954	7041-7058	JJ	denotes	computer-assisted
T3955	7059-7064	NN	denotes	image
T3956	7065-7073	NN	denotes	analysis
T3957	7073-7074	.	denotes	.
T4181	7076-7079	CD	denotes	2.6
T4182	7079-7080	.	denotes	.
T4183	7081-7096	NNP	denotes	Electrophoretic
T4184	7097-7105	NNP	denotes	Mobility
T4185	7106-7111	NNP	denotes	Shift
T4186	7112-7117	NNP	denotes	Assay
T4187	7118-7119	-LRB-	denotes	(
T4188	7119-7123	NNP	denotes	EMSA
T4189	7123-7124	-RRB-	denotes	)
T4190	7125-7132	NNP	denotes	Nuclear
T4191	7133-7141	NNS	denotes	proteins
T4192	7142-7146	VBD	denotes	were
T4193	7147-7155	VBN	denotes	isolated
T4194	7156-7160	IN	denotes	from
T4195	7161-7166	NN	denotes	brain
T4196	7167-7173	NN	denotes	tissue
T4197	7173-7174	.	denotes	.
T4198	7175-7182	RB	denotes	Briefly
T4199	7182-7183	,	denotes	,
T4200	7184-7189	IN	denotes	after
T4201	7190-7197	NN	denotes	removal
T4202	7198-7200	IN	denotes	of
T4203	7201-7212	JJ	denotes	supernatant
T4204	7213-7214	-LRB-	denotes	(
T4205	7214-7225	JJ	denotes	cytoplasmic
T4206	7226-7233	VB	denotes	extract
T4207	7233-7234	-RRB-	denotes	)
T4208	7234-7235	,	denotes	,
T4209	7236-7239	DT	denotes	the
T4210	7240-7247	NNS	denotes	pellets
T4211	7248-7252	VBD	denotes	were
T4212	7253-7264	VBN	denotes	resuspended
T4213	7265-7267	IN	denotes	in
T4214	7268-7275	JJ	denotes	nuclear
T4215	7276-7286	NN	denotes	extraction
T4216	7287-7294	NN	denotes	reagent
T4217	7294-7295	.	denotes	.
T4218	7296-7299	DT	denotes	The
T4219	7300-7305	NNS	denotes	tubes
T4220	7306-7316	VBG	denotes	containing
T4221	7317-7324	NNS	denotes	pellets
T4222	7325-7329	VBD	denotes	were
T4223	7330-7333	VBN	denotes	put
T4224	7334-7336	IN	denotes	on
T4225	7337-7343	NN	denotes	vortex
T4226	7344-7347	IN	denotes	for
T4227	7348-7350	CD	denotes	15
T4228	7351-7358	NNS	denotes	seconds
T4229	7359-7364	DT	denotes	every
T4230	7365-7367	CD	denotes	10
T4231	7368-7375	NNS	denotes	minutes
T4232	7375-7376	,	denotes	,
T4233	7377-7380	IN	denotes	for
T4234	7381-7382	DT	denotes	a
T4235	7383-7388	NN	denotes	total
T4236	7389-7391	IN	denotes	of
T4237	7392-7394	CD	denotes	40
T4238	7395-7402	NNS	denotes	minutes
T4239	7402-7403	.	denotes	.
T4240	7404-7407	DT	denotes	The
T4241	7408-7413	NNS	denotes	tubes
T4242	7414-7418	VBD	denotes	were
T4243	7419-7430	VBN	denotes	centrifuged
T4244	7431-7433	IN	denotes	at
T4245	7434-7441	JJ	denotes	maximum
T4246	7442-7447	NN	denotes	speed
T4247	7448-7449	-LRB-	denotes	(
T4248	7449-7450	FW	denotes	~
T4249	7450-7456	CD	denotes	16,000
T4250	7457-7458	CD	denotes	×
T4251	7459-7460	NN	denotes	g
T4252	7460-7461	-RRB-	denotes	)
T4253	7462-7464	IN	denotes	in
T4254	7465-7466	DT	denotes	a
T4255	7467-7472	NN	denotes	micro
T4256	7473-7483	NN	denotes	centrifuge
T4257	7484-7487	IN	denotes	for
T4258	7488-7490	CD	denotes	10
T4259	7491-7498	NNS	denotes	minutes
T4260	7498-7499	.	denotes	.
T4261	7500-7503	DT	denotes	The
T4262	7504-7516	NNS	denotes	supernatants
T4263	7517-7518	-LRB-	denotes	(
T4264	7518-7525	JJ	denotes	nuclear
T4265	7526-7533	VB	denotes	extract
T4266	7533-7534	-RRB-	denotes	)
T4267	7535-7539	VBD	denotes	were
T4268	7540-7551	VBN	denotes	transferred
T4269	7552-7554	TO	denotes	to
T4270	7555-7556	DT	denotes	a
T4271	7557-7562	JJ	denotes	clean
T4272	7563-7573	JJ	denotes	prechilled
T4273	7574-7578	NN	denotes	tube
T4274	7579-7582	CC	denotes	and
T4275	7583-7589	VBD	denotes	stored
T4276	7590-7592	IN	denotes	at
T4277	7593-7594	CD	denotes	−
T4278	7594-7596	CD	denotes	80
T4279	7596-7597	CD	denotes	°
T4280	7597-7598	NNP	denotes	C
T4281	7599-7604	IN	denotes	until
T4282	7605-7608	NN	denotes	use
T4283	7608-7609	.	denotes	.
T4284	7610-7614	NNP	denotes	EMSA
T4285	7615-7618	VBD	denotes	was
T4286	7619-7628	VBN	denotes	performed
T4287	7629-7631	IN	denotes	as
T4288	7632-7641	VBN	denotes	described
T4289	7642-7652	RB	denotes	previously
T4290	7653-7654	JJ	denotes	[
T4291	7654-7655	CD	denotes	8
T4292	7655-7656	NN	denotes	]
T4293	7656-7657	.	denotes	.
T4294	7658-7662	NNP	denotes	NFκB
T4295	7663-7670	JJ	denotes	binding
T4296	7671-7679	NN	denotes	activity
T4297	7680-7683	VBD	denotes	was
T4298	7684-7692	VBN	denotes	examined
T4299	7693-7695	IN	denotes	in
T4300	7696-7697	DT	denotes	a
T4301	7698-7700	CD	denotes	15
T4302	7701-7703	NN	denotes	μL
T4303	7704-7711	JJ	denotes	binding
T4304	7712-7720	NN	denotes	reaction
T4305	7721-7728	NN	denotes	mixture
T4306	7729-7739	VBG	denotes	containing
T4307	7740-7742	CD	denotes	15
T4308	7743-7745	NN	denotes	μg
T4309	7746-7748	IN	denotes	of
T4310	7749-7756	JJ	denotes	nuclear
T4311	7757-7765	NNS	denotes	proteins
T4312	7766-7769	CC	denotes	and
T4313	7770-7772	CD	denotes	35
T4314	7773-7777	NN	denotes	fmol
T4315	7778-7779	NNP	denotes	[
T4316	7779-7784	NNP	denotes	γ-32P
T4317	7784-7785	NNP	denotes	]
T4318	7786-7793	VBD	denotes	labeled
T4319	7794-7809	JJ	denotes	double-stranded
T4320	7810-7814	NNP	denotes	NFκB
T4321	7815-7824	NN	denotes	consensus
T4322	7825-7840	NN	denotes	oligonucleotide
T4323	7840-7841	.	denotes	.
T4324	7842-7843	DT	denotes	A
T4325	7844-7849	JJ	denotes	super
T4326	7850-7855	NN	denotes	shift
T4327	7856-7861	NN	denotes	assay
T4328	7862-7867	VBG	denotes	using
T4329	7868-7878	NNS	denotes	antibodies
T4330	7879-7881	TO	denotes	to
T4331	7882-7885	NNP	denotes	P65
T4332	7886-7889	CC	denotes	and
T4333	7890-7893	NNP	denotes	P50
T4334	7894-7897	VBD	denotes	was
T4335	7898-7907	VBN	denotes	performed
T4336	7908-7910	TO	denotes	to
T4337	7911-7918	VB	denotes	confirm
T4338	7919-7923	NNP	denotes	NFκB
T4339	7924-7931	JJ	denotes	binding
T4340	7932-7943	NN	denotes	specificity
T4341	7944-7946	IN	denotes	as
T4342	7947-7957	RB	denotes	previously
T4343	7958-7967	VBN	denotes	described
T4344	7967-7968	.	denotes	.
T4426	7970-7973	CD	denotes	2.7
T4427	7973-7974	.	denotes	.
T4428	7975-7986	NNP	denotes	Statistical
T4429	7987-7995	NNP	denotes	Analysis
T4430	7996-7999	NNP	denotes	All
T4431	8000-8004	NNS	denotes	data
T4432	8005-8009	VBD	denotes	were
T4433	8010-8019	VBN	denotes	presented
T4434	8020-8022	IN	denotes	as
T4435	8023-8027	JJ	denotes	mean
T4436	8028-8029	NN	denotes	±
T4437	8030-8033	NNP	denotes	SEM
T4438	8033-8034	.	denotes	.
T4439	8035-8038	DT	denotes	The
T4440	8039-8051	NNS	denotes	measurements
T4441	8052-8056	VBD	denotes	were
T4442	8057-8065	VBN	denotes	analyzed
T4443	8066-8068	IN	denotes	by
T4444	8069-8076	JJ	denotes	one-way
T4445	8077-8085	NN	denotes	analysis
T4446	8086-8088	IN	denotes	of
T4447	8089-8097	NN	denotes	variance
T4448	8098-8099	-LRB-	denotes	(
T4449	8099-8104	NNP	denotes	ANOVA
T4450	8104-8105	-RRB-	denotes	)
T4451	8106-8108	CC	denotes	or
T4452	8109-8116	NN	denotes	Student
T4453	8116-8118	POS	denotes	's
T4454	8119-8125	JJS	denotes	t-test
T4455	8125-8126	.	denotes	.
T4456	8127-8130	DT	denotes	The
T4457	8131-8132	NNP	denotes	P
T4458	8133-8134	NN	denotes	<
T4459	8135-8138	CD	denotes	.05
T4460	8139-8144	NN	denotes	level
T4461	8145-8147	IN	denotes	of
T4462	8148-8159	NN	denotes	probability
T4463	8160-8163	VBD	denotes	was
T4464	8164-8168	VBN	denotes	used
T4465	8169-8171	IN	denotes	as
T4466	8172-8175	DT	denotes	the
T4467	8176-8184	NNS	denotes	criteria
T4468	8185-8187	IN	denotes	of
T4469	8188-8200	NN	denotes	significance
T4470	8200-8201	.	denotes	.
T4653	8215-8218	CD	denotes	3.1
T4654	8218-8219	.	denotes	.
T4655	8220-8224	CD	denotes	TLR4
T4656	8225-8229	NNP	denotes	mRNA
T4657	8230-8239	VBN	denotes	Increased
T4658	8240-8242	IN	denotes	in
T4659	8243-8248	NNP	denotes	Brain
T4660	8249-8255	NNP	denotes	Tissue
T4661	8256-8261	IN	denotes	after
T4662	8262-8265	NNP	denotes	ICH
T4663	8266-8270	CD	denotes	TLR4
T4664	8271-8275	NNP	denotes	mRNA
T4665	8276-8282	NNS	denotes	levels
T4666	8283-8287	VBD	denotes	were
T4667	8288-8296	VBN	denotes	detected
T4668	8297-8299	IN	denotes	by
T4669	8300-8306	NNP	denotes	Rt-PCR
T4670	8306-8307	.	denotes	.
T4671	8308-8311	DT	denotes	The
T4672	8312-8315	JJ	denotes	low
T4673	8316-8321	NN	denotes	level
T4674	8322-8324	IN	denotes	of
T4675	8325-8329	CD	denotes	TLR4
T4676	8330-8334	NNP	denotes	mRNA
T4677	8335-8338	VBD	denotes	was
T4678	8339-8347	VBN	denotes	observed
T4679	8348-8350	IN	denotes	in
T4680	8351-8357	JJ	denotes	normal
T4681	8358-8361	NN	denotes	rat
T4682	8362-8367	NN	denotes	brain
T4683	8368-8374	NN	denotes	tissue
T4684	8374-8375	.	denotes	.
T4685	8376-8378	IN	denotes	In
T4686	8379-8382	DT	denotes	the
T4687	8383-8389	NN	denotes	saline
T4688	8390-8397	NN	denotes	control
T4689	8398-8403	NN	denotes	group
T4690	8403-8404	,	denotes	,
T4691	8405-8408	DT	denotes	the
T4692	8409-8413	CD	denotes	TLR4
T4693	8414-8418	NNP	denotes	mRNA
T4694	8419-8427	RB	denotes	slightly
T4695	8428-8437	VBD	denotes	increased
T4696	8437-8438	,	denotes	,
T4697	8439-8442	CC	denotes	but
T4698	8443-8446	VBD	denotes	was
T4699	8447-8450	RB	denotes	not
T4700	8451-8464	RB	denotes	significantly
T4701	8465-8474	JJ	denotes	different
T4702	8475-8479	IN	denotes	from
T4703	8480-8486	JJ	denotes	normal
T4704	8487-8492	NN	denotes	group
T4705	8492-8493	.	denotes	.
T4706	8494-8501	RB	denotes	However
T4707	8501-8502	,	denotes	,
T4708	8503-8506	DT	denotes	the
T4709	8507-8511	NNP	denotes	TLR4
T4710	8512-8516	NNP	denotes	mRNA
T4711	8517-8522	IN	denotes	after
T4712	8523-8526	NNP	denotes	ICH
T4713	8527-8540	RB	denotes	significantly
T4714	8541-8550	VBD	denotes	increased
T4715	8551-8559	VBG	denotes	starting
T4716	8560-8564	IN	denotes	from
T4717	8565-8566	CD	denotes	6
T4718	8567-8572	NNS	denotes	hours
T4719	8573-8578	IN	denotes	after
T4720	8579-8582	NNP	denotes	ICH
T4721	8583-8584	-LRB-	denotes	(
T4722	8584-8585	NNP	denotes	P
T4723	8586-8587	CD	denotes	<
T4724	8588-8591	CD	denotes	.05
T4725	8591-8592	-RRB-	denotes	)
T4726	8592-8593	,	denotes	,
T4727	8594-8600	VBD	denotes	peaked
T4728	8601-8603	IN	denotes	on
T4729	8604-8607	DT	denotes	the
T4730	8608-8611	JJ	denotes	3rd
T4731	8612-8615	NN	denotes	day
T4732	8616-8621	IN	denotes	after
T4733	8622-8625	NNP	denotes	ICH
T4734	8625-8626	,	denotes	,
T4735	8627-8630	CC	denotes	and
T4736	8631-8635	RB	denotes	then
T4737	8636-8645	VBD	denotes	decreased
T4738	8646-8648	IN	denotes	on
T4739	8649-8652	DT	denotes	the
T4740	8653-8656	JJ	denotes	7th
T4741	8657-8660	NN	denotes	day
T4742	8661-8666	IN	denotes	after
T4743	8667-8670	NNP	denotes	ICH
T4744	8671-8672	-LRB-	denotes	(
T4745	8672-8673	NNP	denotes	P
T4746	8674-8675	CD	denotes	<
T4747	8676-8679	CD	denotes	.05
T4748	8679-8680	-RRB-	denotes	)
T4749	8680-8681	,	denotes	,
T4750	8682-8685	CC	denotes	but
T4751	8686-8691	RB	denotes	still
T4752	8692-8702	VBD	denotes	maintained
T4753	8703-8704	DT	denotes	a
T4754	8705-8711	JJR	denotes	higher
T4755	8712-8717	NN	denotes	level
T4756	8718-8726	VBN	denotes	compared
T4757	8727-8731	IN	denotes	with
T4758	8732-8738	NN	denotes	saline
T4759	8739-8746	NN	denotes	control
T4760	8747-8748	-LRB-	denotes	(
T4761	8748-8749	NNP	denotes	P
T4762	8750-8751	CD	denotes	<
T4763	8752-8755	CD	denotes	.05
T4764	8755-8756	,	denotes	,
T4765	8757-8763	NNP	denotes	Figure
T4766	8764-8765	CD	denotes	1
T4767	8765-8766	-RRB-	denotes	)
T4768	8766-8767	.	denotes	.
T5083	8769-8772	CD	denotes	3.2
T5084	8772-8773	.	denotes	.
T5085	8774-8784	NN	denotes	Expression
T5086	8785-8787	IN	denotes	of
T5087	8788-8792	CD	denotes	TLR4
T5088	8793-8800	NNP	denotes	Protein
T5089	8801-8810	VBN	denotes	Increased
T5090	8811-8813	IN	denotes	in
T5091	8814-8819	NNP	denotes	Brain
T5092	8820-8826	NNP	denotes	Tissue
T5093	8827-8832	IN	denotes	after
T5094	8833-8836	NNP	denotes	ICH
T5095	8837-8839	TO	denotes	To
T5096	8840-8851	VB	denotes	investigate
T5097	8852-8855	DT	denotes	the
T5098	8856-8865	VBN	denotes	increased
T5099	8866-8870	CD	denotes	TLR4
T5100	8871-8873	IN	denotes	at
T5101	8874-8877	DT	denotes	the
T5102	8878-8885	NN	denotes	protein
T5103	8886-8891	NN	denotes	level
T5104	8891-8892	,	denotes	,
T5105	8893-8896	DT	denotes	the
T5106	8897-8907	NN	denotes	expression
T5107	8908-8910	IN	denotes	of
T5108	8911-8915	CD	denotes	TLR4
T5109	8916-8923	NN	denotes	protein
T5110	8924-8927	VBD	denotes	was
T5111	8928-8936	VBN	denotes	measured
T5112	8937-8939	IN	denotes	in
T5113	8940-8945	NN	denotes	brain
T5114	8946-8952	NN	denotes	tissue
T5115	8953-8955	IN	denotes	by
T5116	8956-8959	DT	denotes	the
T5117	8960-8966	NN	denotes	method
T5118	8967-8969	IN	denotes	of
T5119	8970-8977	JJ	denotes	Western
T5120	8978-8983	NNS	denotes	Blots
T5121	8984-8989	VBG	denotes	using
T5122	8990-8998	JJ	denotes	specific
T5123	8999-9009	NNS	denotes	antibodies
T5124	9010-9013	IN	denotes	for
T5125	9014-9018	CD	denotes	TLR4
T5126	9018-9019	.	denotes	.
T5127	9020-9023	PRP$	denotes	Our
T5128	9024-9031	NNS	denotes	results
T5129	9032-9038	VBD	denotes	showed
T5130	9039-9043	IN	denotes	that
T5131	9044-9045	DT	denotes	a
T5132	9046-9049	JJ	denotes	low
T5133	9050-9055	NN	denotes	level
T5134	9056-9058	IN	denotes	of
T5135	9059-9063	CD	denotes	TLR4
T5136	9064-9071	NN	denotes	protein
T5137	9072-9075	VBD	denotes	was
T5138	9076-9086	JJ	denotes	detectable
T5139	9087-9089	IN	denotes	in
T5140	9090-9093	DT	denotes	the
T5141	9094-9100	NN	denotes	saline
T5142	9101-9108	NN	denotes	control
T5143	9109-9114	NN	denotes	group
T5144	9114-9115	.	denotes	.
T5145	9116-9119	DT	denotes	The
T5146	9120-9130	NN	denotes	expression
T5147	9131-9133	IN	denotes	of
T5148	9134-9138	CD	denotes	TLR4
T5149	9139-9152	RB	denotes	significantly
T5150	9153-9162	VBD	denotes	increased
T5151	9163-9171	VBG	denotes	starting
T5152	9172-9176	IN	denotes	from
T5153	9177-9178	CD	denotes	6
T5154	9179-9184	NNS	denotes	hours
T5155	9185-9190	IN	denotes	after
T5156	9191-9194	NNP	denotes	ICH
T5157	9195-9196	-LRB-	denotes	(
T5158	9196-9197	NNP	denotes	P
T5159	9198-9199	CD	denotes	<
T5160	9200-9203	CD	denotes	.05
T5161	9203-9204	-RRB-	denotes	)
T5162	9204-9205	,	denotes	,
T5163	9206-9212	VBD	denotes	peaked
T5164	9213-9215	IN	denotes	on
T5165	9216-9219	DT	denotes	the
T5166	9220-9223	JJ	denotes	3rd
T5167	9224-9227	NN	denotes	day
T5168	9228-9233	IN	denotes	after
T5169	9234-9237	NNP	denotes	ICH
T5170	9237-9238	,	denotes	,
T5171	9239-9242	CC	denotes	and
T5172	9243-9247	RB	denotes	then
T5173	9248-9257	VBD	denotes	decreased
T5174	9258-9261	CC	denotes	but
T5175	9262-9267	RB	denotes	still
T5176	9268-9278	VBN	denotes	maintained
T5177	9279-9281	IN	denotes	at
T5178	9282-9283	DT	denotes	a
T5179	9284-9288	JJ	denotes	high
T5180	9289-9294	NN	denotes	level
T5181	9295-9297	IN	denotes	on
T5182	9298-9301	DT	denotes	the
T5183	9302-9305	JJ	denotes	7th
T5184	9306-9309	NN	denotes	day
T5185	9310-9315	IN	denotes	after
T5186	9316-9319	NNP	denotes	ICH
T5187	9320-9321	-LRB-	denotes	(
T5188	9321-9322	NNP	denotes	P
T5189	9323-9324	CD	denotes	<
T5190	9325-9328	CD	denotes	.05
T5191	9328-9329	,	denotes	,
T5192	9330-9336	NN	denotes	Figure
T5193	9337-9338	CD	denotes	2
T5194	9338-9339	-RRB-	denotes	)
T5195	9339-9340	.	denotes	.
T5196	9341-9345	DT	denotes	This
T5197	9346-9357	NN	denotes	observation
T5198	9358-9360	IN	denotes	of
T5199	9361-9365	CD	denotes	TLR4
T5200	9366-9373	NN	denotes	protein
T5201	9374-9377	VBD	denotes	was
T5202	9378-9388	JJ	denotes	consistent
T5203	9389-9393	IN	denotes	with
T5204	9394-9397	DT	denotes	the
T5205	9398-9406	JJ	denotes	temporal
T5206	9407-9414	NN	denotes	profile
T5207	9415-9417	IN	denotes	of
T5208	9418-9421	DT	denotes	the
T5209	9422-9426	CD	denotes	TLR4
T5210	9427-9431	NNP	denotes	mRNA
T5211	9432-9437	IN	denotes	after
T5212	9438-9441	NNP	denotes	ICH
T5213	9441-9442	.	denotes	.
T5462	9444-9447	CD	denotes	3.3
T5463	9447-9448	.	denotes	.
T5464	9449-9461	NN	denotes	Distribution
T5465	9462-9464	IN	denotes	of
T5466	9465-9469	CD	denotes	TLR4
T5467	9470-9472	IN	denotes	in
T5468	9473-9478	NNP	denotes	Brain
T5469	9479-9488	NNP	denotes	Subjected
T5470	9489-9491	TO	denotes	to
T5471	9492-9495	NNP	denotes	ICH
T5472	9496-9498	TO	denotes	To
T5473	9499-9506	VB	denotes	explore
T5474	9507-9510	DT	denotes	the
T5475	9511-9523	NN	denotes	distribution
T5476	9524-9526	IN	denotes	of
T5477	9527-9531	CD	denotes	TLR4
T5478	9532-9539	NN	denotes	protein
T5479	9539-9540	,	denotes	,
T5480	9541-9544	DT	denotes	the
T5481	9545-9549	NNP	denotes	TLR4
T5482	9550-9553	VBD	denotes	was
T5483	9554-9562	VBN	denotes	detected
T5484	9563-9565	IN	denotes	by
T5485	9566-9586	NN	denotes	immunohistochemistry
T5486	9587-9588	-LRB-	denotes	(
T5487	9588-9591	NNP	denotes	IHC
T5488	9591-9592	-RRB-	denotes	)
T5489	9592-9593	.	denotes	.
T5490	9594-9601	NNS	denotes	Results
T5491	9602-9608	VBD	denotes	showed
T5492	9609-9613	IN	denotes	that
T5493	9614-9618	CD	denotes	TLR4
T5494	9619-9635	NN	denotes	immunoreactivity
T5495	9636-9639	VBD	denotes	was
T5496	9640-9643	RB	denotes	not
T5497	9644-9654	JJ	denotes	detectable
T5498	9655-9657	IN	denotes	in
T5499	9658-9663	NN	denotes	brain
T5500	9664-9670	NN	denotes	tissue
T5501	9671-9675	IN	denotes	from
T5502	9676-9682	JJ	denotes	normal
T5503	9683-9686	CC	denotes	and
T5504	9687-9691	JJ	denotes	sham
T5505	9692-9699	NN	denotes	control
T5506	9699-9700	.	denotes	.
T5507	9701-9708	RB	denotes	However
T5508	9708-9709	,	denotes	,
T5509	9710-9726	NN	denotes	immunoreactivity
T5510	9727-9730	IN	denotes	for
T5511	9731-9735	CD	denotes	TLR4
T5512	9736-9739	VBD	denotes	was
T5513	9740-9752	RB	denotes	consistently
T5514	9753-9765	VBN	denotes	demonstrated
T5515	9766-9768	IN	denotes	in
T5516	9769-9784	JJ	denotes	peri-hemorrhage
T5517	9785-9790	NNS	denotes	areas
T5518	9790-9791	,	denotes	,
T5519	9792-9795	DT	denotes	the
T5520	9796-9807	NN	denotes	hippocampus
T5521	9807-9808	,	denotes	,
T5522	9809-9815	NN	denotes	cortex
T5523	9815-9816	,	denotes	,
T5524	9817-9825	JJ	denotes	thalamic
T5525	9826-9832	NNS	denotes	nuclei
T5526	9832-9833	,	denotes	,
T5527	9834-9837	CC	denotes	and
T5528	9838-9842	DT	denotes	some
T5529	9843-9848	JJ	denotes	white
T5530	9849-9855	NN	denotes	matter
T5531	9856-9862	NNS	denotes	tracts
T5532	9863-9864	-LRB-	denotes	(
T5533	9864-9870	NN	denotes	Figure
T5534	9871-9872	CD	denotes	3
T5535	9872-9873	-RRB-	denotes	)
T5536	9873-9874	.	denotes	.
T5807	9876-9879	CD	denotes	3.4
T5808	9879-9880	.	denotes	.
T5809	9881-9891	NNP	denotes	Activation
T5810	9892-9894	IN	denotes	of
T5811	9895-9908	NNP	denotes	TLR4-Mediated
T5812	9909-9919	NNP	denotes	NF-Kappa-B
T5813	9920-9929	NNP	denotes	Signaling
T5814	9930-9940	NNP	denotes	Activation
T5815	9941-9943	IN	denotes	of
T5816	9944-9948	CD	denotes	TLR4
T5817	9949-9956	VBZ	denotes	induces
T5818	9957-9960	DT	denotes	the
T5819	9961-9976	NN	denotes	phosphorylation
T5820	9977-9979	IN	denotes	of
T5821	9980-9989	NN	denotes	inhibitor
T5822	9990-9992	IN	denotes	of
T5823	9993-10000	NNP	denotes	kappa-B
T5824	10001-10002	-LRB-	denotes	(
T5825	10002-10005	NNP	denotes	IκB
T5826	10005-10006	-RRB-	denotes	)
T5827	10006-10007	,	denotes	,
T5828	10008-10013	WDT	denotes	which
T5829	10014-10025	VBZ	denotes	dissociates
T5830	10026-10029	NNP	denotes	IκB
T5831	10030-10034	IN	denotes	with
T5832	10035-10045	NNP	denotes	NF-kappa-B
T5833	10046-10047	-LRB-	denotes	(
T5834	10047-10051	NNP	denotes	NFκB
T5835	10051-10052	-RRB-	denotes	)
T5836	10052-10053	.	denotes	.
T5837	10054-10058	RB	denotes	Then
T5838	10058-10059	,	denotes	,
T5839	10060-10064	NNP	denotes	NFκB
T5840	10065-10077	VBZ	denotes	translocates
T5841	10078-10082	IN	denotes	into
T5842	10083-10086	DT	denotes	the
T5843	10087-10094	NN	denotes	nucleus
T5844	10095-10098	CC	denotes	and
T5845	10099-10108	NNS	denotes	activates
T5846	10109-10112	CC	denotes	and
T5847	10113-10122	VBZ	denotes	regulates
T5848	10123-10126	DT	denotes	the
T5849	10127-10140	NN	denotes	transcription
T5850	10141-10143	IN	denotes	of
T5851	10144-10149	NNS	denotes	genes
T5852	10150-10157	VBN	denotes	related
T5853	10158-10160	TO	denotes	to
T5854	10161-10173	JJ	denotes	inflammatory
T5855	10174-10183	NNS	denotes	responses
T5856	10183-10184	.	denotes	.
T5857	10185-10187	TO	denotes	To
T5858	10188-10195	VB	denotes	detectd
T5859	10196-10199	DT	denotes	the
T5860	10200-10210	NN	denotes	activation
T5861	10211-10213	IN	denotes	of
T5862	10214-10227	JJ	denotes	TLR4-mediated
T5863	10228-10232	NNP	denotes	NFκB
T5864	10233-10242	VBG	denotes	signaling
T5865	10242-10243	,	denotes	,
T5866	10244-10247	DT	denotes	the
T5867	10248-10263	NN	denotes	phosphorylation
T5868	10264-10266	IN	denotes	of
T5869	10267-10276	NN	denotes	inhibitor
T5870	10277-10279	IN	denotes	of
T5871	10280-10287	NNP	denotes	kappa-B
T5872	10288-10289	-LRB-	denotes	(
T5873	10289-10294	NNP	denotes	p-IκB
T5874	10294-10295	-RRB-	denotes	)
T5875	10296-10299	CC	denotes	and
T5876	10300-10308	NN	denotes	activity
T5877	10309-10311	IN	denotes	of
T5878	10312-10316	NNP	denotes	NFκB
T5879	10317-10321	VBD	denotes	were
T5880	10322-10330	VBN	denotes	measured
T5881	10331-10333	IN	denotes	by
T5882	10334-10341	NNS	denotes	methods
T5883	10342-10344	IN	denotes	of
T5884	10345-10352	JJ	denotes	Western
T5885	10353-10358	NNS	denotes	Blots
T5886	10359-10362	CC	denotes	and
T5887	10363-10367	NNP	denotes	EMSA
T5888	10367-10368	.	denotes	.
T5889	10369-10376	NNS	denotes	Results
T5890	10377-10383	VBD	denotes	showed
T5891	10384-10388	IN	denotes	that
T5892	10389-10392	DT	denotes	the
T5893	10393-10398	NN	denotes	p-IκB
T5894	10399-10408	VBD	denotes	increased
T5895	10409-10411	IN	denotes	at
T5896	10412-10413	CD	denotes	6
T5897	10414-10419	NNS	denotes	hours
T5898	10420-10425	IN	denotes	after
T5899	10426-10429	NNP	denotes	ICH
T5900	10430-10431	-LRB-	denotes	(
T5901	10431-10432	NNP	denotes	P
T5902	10433-10434	CD	denotes	<
T5903	10435-10438	CD	denotes	.05
T5904	10438-10439	-RRB-	denotes	)
T5905	10439-10440	,	denotes	,
T5906	10441-10447	VBD	denotes	peaked
T5907	10448-10450	IN	denotes	on
T5908	10451-10452	CD	denotes	3
T5909	10453-10457	NNS	denotes	days
T5910	10458-10463	IN	denotes	after
T5911	10464-10467	NNP	denotes	ICH
T5912	10467-10468	,	denotes	,
T5913	10469-10472	CC	denotes	and
T5914	10473-10483	VBD	denotes	maintained
T5915	10484-10485	DT	denotes	a
T5916	10486-10490	JJ	denotes	high
T5917	10491-10496	NN	denotes	level
T5918	10497-10499	IN	denotes	on
T5919	10500-10501	CD	denotes	7
T5920	10502-10506	NNS	denotes	days
T5921	10507-10512	IN	denotes	after
T5922	10513-10516	NNP	denotes	ICH
T5923	10517-10518	-LRB-	denotes	(
T5924	10518-10519	NNP	denotes	P
T5925	10520-10521	CD	denotes	<
T5926	10522-10525	CD	denotes	.05
T5927	10525-10526	,	denotes	,
T5928	10527-10533	NN	denotes	Figure
T5929	10534-10535	CD	denotes	5
T5930	10535-10536	-RRB-	denotes	)
T5931	10536-10537	.	denotes	.
T5932	10538-10540	IN	denotes	As
T5933	10541-10549	VBN	denotes	expected
T5934	10549-10550	,	denotes	,
T5935	10551-10554	DT	denotes	the
T5936	10555-10563	NN	denotes	activity
T5937	10564-10566	IN	denotes	of
T5938	10567-10571	NNP	denotes	NFκB
T5939	10572-10575	VBD	denotes	was
T5940	10576-10580	RB	denotes	also
T5941	10581-10590	VBN	denotes	increased
T5942	10591-10593	IN	denotes	in
T5943	10594-10597	DT	denotes	the
T5944	10598-10602	JJ	denotes	same
T5945	10603-10609	NN	denotes	manner
T5946	10610-10612	IN	denotes	as
T5947	10613-10617	DT	denotes	that
T5948	10618-10620	IN	denotes	of
T5949	10621-10624	DT	denotes	the
T5950	10625-10630	NN	denotes	p-IκB
T5951	10631-10632	-LRB-	denotes	(
T5952	10632-10638	NN	denotes	Figure
T5953	10639-10640	CD	denotes	4
T5954	10640-10641	-RRB-	denotes	)
T5955	10641-10642	.	denotes	.
T7577	10658-10672	JJ	denotes	Intra-cerebral
T7578	10673-10683	NN	denotes	hemorrhage
T7579	10684-10685	-LRB-	denotes	(
T7580	10685-10688	NNP	denotes	ICH
T7581	10688-10689	-RRB-	denotes	)
T7582	10690-10700	VBZ	denotes	represents
T7583	10701-10703	CD	denotes	10
T7584	10704-10706	CD	denotes	15
T7585	10706-10707	NN	denotes	%
T7586	10708-10710	IN	denotes	of
T7587	10711-10714	DT	denotes	all
T7588	10715-10722	NNS	denotes	strokes
T7589	10722-10723	,	denotes	,
T7590	10724-10727	CC	denotes	and
T7591	10728-10734	VBZ	denotes	occurs
T7592	10735-10739	IN	denotes	with
T7593	10740-10750	VBG	denotes	increasing
T7594	10751-10760	NN	denotes	frequency
T7595	10761-10763	IN	denotes	as
T7596	10764-10765	DT	denotes	a
T7597	10766-10778	NN	denotes	complication
T7598	10779-10781	IN	denotes	of
T7599	10782-10785	DT	denotes	the
T7600	10786-10798	JJ	denotes	thrombolytic
T7601	10799-10808	NN	denotes	treatment
T7602	10809-10811	IN	denotes	of
T7603	10812-10820	JJ	denotes	ischemic
T7604	10821-10827	NN	denotes	stroke
T7605	10828-10829	NNP	denotes	[
T7606	10829-10830	CD	denotes	1
T7607	10830-10831	NNP	denotes	]
T7608	10831-10832	.	denotes	.
T7609	10833-10836	DT	denotes	The
T7610	10837-10846	NN	denotes	mortality
T7611	10847-10849	IN	denotes	of
T7612	10850-10853	NNP	denotes	ICH
T7613	10854-10856	VBZ	denotes	is
T7614	10857-10863	JJR	denotes	higher
T7615	10864-10868	IN	denotes	than
T7616	10869-10873	DT	denotes	that
T7617	10874-10876	IN	denotes	of
T7618	10877-10885	JJ	denotes	ischemic
T7619	10886-10892	NN	denotes	stroke
T7620	10892-10893	.	denotes	.
T7621	10894-10898	RB	denotes	Only
T7622	10899-10901	CD	denotes	31
T7623	10901-10902	NN	denotes	%
T7624	10903-10906	VBP	denotes	are
T7625	10907-10919	RB	denotes	functionally
T7626	10920-10931	JJ	denotes	independent
T7627	10932-10934	IN	denotes	at
T7628	10935-10936	CD	denotes	3
T7629	10937-10943	NNS	denotes	months
T7630	10943-10944	.	denotes	.
T7631	10945-10949	RB	denotes	Only
T7632	10950-10952	CD	denotes	38
T7633	10952-10953	NN	denotes	%
T7634	10954-10956	IN	denotes	of
T7635	10957-10960	DT	denotes	the
T7636	10961-10969	NNS	denotes	patients
T7637	10970-10977	VBP	denotes	survive
T7638	10978-10981	DT	denotes	the
T7639	10982-10985	CD	denotes	1st
T7640	10986-10990	NN	denotes	year
T7641	10991-10992	NNP	denotes	[
T7642	10992-10994	CD	denotes	10
T7643	10994-10995	NNP	denotes	]
T7644	10995-10996	.	denotes	.
T7645	10997-11010	RB	denotes	Unfortunately
T7646	11010-11011	,	denotes	,
T7647	11012-11015	DT	denotes	the
T7648	11016-11022	NN	denotes	method
T7649	11023-11026	IN	denotes	for
T7650	11027-11036	NN	denotes	treatment
T7651	11037-11039	IN	denotes	of
T7652	11040-11044	DT	denotes	this
T7653	11045-11052	NN	denotes	disease
T7654	11053-11056	CC	denotes	and
T7655	11057-11067	NN	denotes	protection
T7656	11068-11070	IN	denotes	of
T7657	11071-11074	DT	denotes	the
T7658	11075-11080	NN	denotes	brain
T7659	11081-11087	NN	denotes	tissue
T7660	11088-11093	IN	denotes	after
T7661	11094-11097	NNP	denotes	ICH
T7662	11098-11101	VBP	denotes	are
T7663	11102-11105	RB	denotes	not
T7664	11106-11115	JJ	denotes	effective
T7665	11115-11116	.	denotes	.
T7666	11117-11121	NNP	denotes	Mass
T7667	11122-11128	NN	denotes	effect
T7668	11128-11129	,	denotes	,
T7669	11130-11138	NN	denotes	ischemia
T7670	11138-11139	,	denotes	,
T7671	11140-11143	CC	denotes	and
T7672	11144-11152	NN	denotes	toxicity
T7673	11153-11155	IN	denotes	of
T7674	11156-11161	NN	denotes	blood
T7675	11162-11172	NNS	denotes	components
T7676	11173-11178	IN	denotes	after
T7677	11179-11182	NNP	denotes	ICH
T7678	11183-11189	VB	denotes	induce
T7679	11190-11195	NN	denotes	brain
T7680	11196-11202	NN	denotes	tissue
T7681	11203-11209	NN	denotes	damage
T7682	11209-11210	.	denotes	.
T7683	11211-11213	IN	denotes	In
T7684	11214-11222	NN	denotes	addition
T7685	11222-11223	,	denotes	,
T7686	11224-11229	EX	denotes	there
T7687	11230-11232	VBZ	denotes	is
T7688	11233-11243	VBG	denotes	increasing
T7689	11244-11252	NN	denotes	evidence
T7690	11253-11257	IN	denotes	that
T7691	11258-11270	JJ	denotes	inflammatory
T7692	11271-11280	NNS	denotes	processes
T7693	11281-11284	VBP	denotes	are
T7694	11285-11293	VBN	denotes	involved
T7695	11294-11296	IN	denotes	in
T7696	11297-11312	JJ	denotes	cerebrovascular
T7697	11313-11319	NNS	denotes	events
T7698	11319-11320	.	denotes	.
T7699	11321-11326	IN	denotes	After
T7700	11327-11330	NNP	denotes	ICH
T7701	11330-11331	,	denotes	,
T7702	11332-11344	JJ	denotes	inflammatory
T7703	11345-11354	NNS	denotes	mediators
T7704	11355-11359	IN	denotes	from
T7705	11360-11363	DT	denotes	the
T7706	11364-11369	NN	denotes	blood
T7707	11370-11375	MD	denotes	might
T7708	11376-11381	VB	denotes	enter
T7709	11382-11384	TO	denotes	to
T7710	11385-11388	DT	denotes	the
T7711	11389-11394	NN	denotes	brain
T7712	11395-11398	CC	denotes	and
T7713	11399-11405	VB	denotes	induce
T7714	11406-11408	DT	denotes	an
T7715	11409-11421	JJ	denotes	inflammatory
T7716	11422-11430	NN	denotes	reaction
T7717	11431-11434	CC	denotes	and
T7718	11435-11438	DT	denotes	the
T7719	11439-11444	NN	denotes	brain
T7720	11445-11450	NNS	denotes	cells
T7721	11451-11457	PRP	denotes	itself
T7722	11458-11461	VBP	denotes	are
T7723	11462-11466	RB	denotes	also
T7724	11467-11474	JJ	denotes	capable
T7725	11475-11477	IN	denotes	of
T7726	11478-11487	VBG	denotes	producing
T7727	11488-11492	JJ	denotes	many
T7728	11493-11495	IN	denotes	of
T7729	11496-11501	DT	denotes	these
T7730	11502-11508	NNS	denotes	agents
T7731	11509-11510	NNP	denotes	[
T7732	11510-11512	CD	denotes	11
T7733	11512-11513	NNP	denotes	]
T7734	11513-11514	.	denotes	.
T7735	11515-11518	DT	denotes	The
T7736	11519-11531	JJ	denotes	inflammatory
T7737	11532-11541	NNS	denotes	responses
T7738	11542-11545	VBP	denotes	are
T7739	11546-11557	JJ	denotes	responsible
T7740	11558-11561	IN	denotes	for
T7741	11562-11565	DT	denotes	the
T7742	11566-11569	NNP	denotes	ICH
T7743	11570-11577	VBD	denotes	induced
T7744	11578-11583	NN	denotes	brain
T7745	11584-11590	NN	denotes	injury
T7746	11590-11591	,	denotes	,
T7747	11592-11597	WDT	denotes	which
T7748	11598-11603	MD	denotes	could
T7749	11604-11611	VB	denotes	provide
T7750	11612-11615	JJ	denotes	new
T7751	11616-11627	JJ	denotes	therapeutic
T7752	11628-11635	NNS	denotes	targets
T7753	11636-11639	IN	denotes	for
T7754	11640-11643	NNP	denotes	ICH
T7755	11643-11644	.	denotes	.
T7756	11645-11652	JJ	denotes	Various
T7757	11653-11665	NNS	denotes	constituents
T7758	11666-11668	IN	denotes	of
T7759	11669-11672	DT	denotes	the
T7760	11673-11685	JJ	denotes	inflammatory
T7761	11686-11694	NN	denotes	response
T7762	11694-11695	,	denotes	,
T7763	11696-11705	VBG	denotes	including
T7764	11706-11714	NN	denotes	adhesion
T7765	11715-11724	NNS	denotes	molecules
T7766	11724-11725	,	denotes	,
T7767	11726-11735	NNS	denotes	cytokines
T7768	11735-11736	,	denotes	,
T7769	11737-11747	NNS	denotes	leukocytes
T7770	11747-11748	,	denotes	,
T7771	11749-11764	NNS	denotes	immunoglobulins
T7772	11764-11765	,	denotes	,
T7773	11766-11769	CC	denotes	and
T7774	11770-11780	VBP	denotes	complement
T7775	11780-11781	,	denotes	,
T7776	11782-11785	MD	denotes	may
T7777	11786-11788	VB	denotes	be
T7778	11789-11798	JJ	denotes	important
T7779	11799-11801	IN	denotes	in
T7780	11802-11805	DT	denotes	the
T7781	11806-11818	NN	denotes	pathogenesis
T7782	11819-11821	IN	denotes	of
T7783	11822-11825	NNP	denotes	ICH
T7784	11825-11826	.	denotes	.
T7785	11827-11834	RB	denotes	However
T7786	11834-11835	,	denotes	,
T7787	11836-11839	WRB	denotes	how
T7788	11840-11843	DT	denotes	the
T7789	11844-11856	JJ	denotes	inflammatory
T7790	11857-11866	NNS	denotes	responses
T7791	11867-11869	VBZ	denotes	is
T7792	11870-11879	VBN	denotes	activated
T7793	11880-11883	CC	denotes	and
T7794	11884-11893	VBN	denotes	regulated
T7795	11894-11896	IN	denotes	in
T7796	11897-11900	DT	denotes	the
T7797	11901-11906	NN	denotes	brain
T7798	11907-11913	NN	denotes	tissue
T7799	11914-11919	IN	denotes	after
T7800	11920-11923	NNP	denotes	ICH
T7801	11924-11926	VBZ	denotes	is
T7802	11927-11934	JJ	denotes	unclear
T7803	11934-11935	.	denotes	.
T7804	11936-11949	NNP	denotes	Transcription
T7805	11950-11956	NN	denotes	factor
T7806	11957-11964	JJ	denotes	nuclear
T7807	11965-11979	NNP	denotes	factor-kappa-B
T7808	11980-11981	-LRB-	denotes	(
T7809	11981-11985	NNP	denotes	NFκB
T7810	11985-11986	-RRB-	denotes	)
T7811	11987-11989	VBZ	denotes	is
T7812	11990-11992	DT	denotes	an
T7813	11993-12002	JJ	denotes	important
T7814	12003-12010	JJ	denotes	nuclear
T7815	12011-12024	NN	denotes	transcription
T7816	12025-12031	NN	denotes	factor
T7817	12031-12032	,	denotes	,
T7818	12033-12038	WDT	denotes	which
T7819	12039-12048	VBZ	denotes	initiates
T7820	12049-12062	NN	denotes	transcription
T7821	12063-12065	IN	denotes	of
T7822	12066-12071	NNS	denotes	genes
T7823	12072-12082	VBN	denotes	associated
T7824	12083-12087	IN	denotes	with
T7825	12088-12094	JJ	denotes	immune
T7826	12095-12104	NNS	denotes	responses
T7827	12105-12108	CC	denotes	and
T7828	12109-12121	NN	denotes	inflammation
T7829	12122-12123	NNP	denotes	[
T7830	12123-12125	CD	denotes	12
T7831	12125-12126	,	denotes	,
T7832	12127-12129	CD	denotes	13
T7833	12129-12130	NN	denotes	]
T7834	12131-12134	CC	denotes	and
T7835	12135-12139	RB	denotes	also
T7836	12140-12145	VBZ	denotes	plays
T7837	12146-12147	DT	denotes	a
T7838	12148-12151	JJ	denotes	key
T7839	12152-12156	NN	denotes	role
T7840	12157-12159	IN	denotes	in
T7841	12160-12170	VBG	denotes	regulating
T7842	12171-12183	NN	denotes	inflammation
T7843	12184-12186	IN	denotes	in
T7844	12187-12192	NN	denotes	brain
T7845	12193-12204	NNS	denotes	pathologies
T7846	12204-12205	.	denotes	.
T7847	12206-12208	PRP	denotes	It
T7848	12209-12212	VBZ	denotes	has
T7849	12213-12217	VBN	denotes	been
T7850	12218-12226	VBN	denotes	reported
T7851	12227-12231	IN	denotes	that
T7852	12232-12236	NNP	denotes	NFκB
T7853	12237-12246	VBD	denotes	increased
T7854	12247-12249	IN	denotes	in
T7855	12250-12253	DT	denotes	the
T7856	12254-12260	NN	denotes	region
T7857	12261-12263	IN	denotes	of
T7858	12264-12276	NN	denotes	perihematoma
T7859	12277-12282	IN	denotes	after
T7860	12283-12286	NNP	denotes	ICH
T7861	12287-12288	NNP	denotes	[
T7862	12288-12290	CD	denotes	14
T7863	12290-12291	NNP	denotes	]
T7864	12291-12292	.	denotes	.
T7865	12293-12297	NNP	denotes	NFκB
T7866	12298-12308	NN	denotes	activation
T7867	12309-12315	VBZ	denotes	occurs
T7868	12316-12322	IN	denotes	within
T7869	12323-12330	NNS	denotes	minutes
T7870	12331-12334	CC	denotes	and
T7871	12335-12343	VBZ	denotes	persists
T7872	12344-12347	IN	denotes	for
T7873	12348-12350	IN	denotes	at
T7874	12351-12356	JJS	denotes	least
T7875	12357-12358	DT	denotes	a
T7876	12359-12363	NN	denotes	week
T7877	12364-12366	IN	denotes	in
T7878	12367-12375	NN	denotes	response
T7879	12376-12378	TO	denotes	to
T7880	12379-12382	NNP	denotes	ICH
T7881	12382-12383	,	denotes	,
T7882	12384-12389	WDT	denotes	which
T7883	12390-12392	VBZ	denotes	is
T7884	12393-12403	VBN	denotes	associated
T7885	12404-12408	IN	denotes	with
T7886	12409-12412	DT	denotes	the
T7887	12413-12423	NN	denotes	expression
T7888	12424-12426	IN	denotes	of
T7889	12427-12435	VBN	denotes	selected
T7890	12436-12442	NN	denotes	target
T7891	12443-12448	NNS	denotes	genes
T7892	12449-12450	NNP	denotes	[
T7893	12450-12452	CD	denotes	15
T7894	12452-12453	NNP	denotes	]
T7895	12453-12454	.	denotes	.
T7896	12455-12465	NNP	denotes	Activation
T7897	12466-12468	IN	denotes	of
T7898	12469-12473	NNP	denotes	NFκB
T7899	12474-12483	VBZ	denotes	initiates
T7900	12484-12496	JJ	denotes	inflammatory
T7901	12497-12506	NNS	denotes	responses
T7902	12507-12510	CC	denotes	and
T7903	12511-12522	VBZ	denotes	contributes
T7904	12523-12525	TO	denotes	to
T7905	12526-12529	DT	denotes	the
T7906	12530-12542	NN	denotes	pathobiology
T7907	12543-12545	IN	denotes	of
T7908	12546-12558	JJ	denotes	perilesional
T7909	12559-12563	NN	denotes	cell
T7910	12564-12569	NN	denotes	death
T7911	12570-12575	IN	denotes	after
T7912	12576-12579	NNP	denotes	ICH
T7913	12580-12581	NNP	denotes	[
T7914	12581-12583	CD	denotes	16
T7915	12583-12584	NNP	denotes	]
T7916	12584-12585	.	denotes	.
T7917	12586-12596	NNP	denotes	Inhibition
T7918	12597-12599	IN	denotes	of
T7919	12600-12604	NNP	denotes	NFκB
T7920	12605-12613	NN	denotes	activity
T7921	12614-12617	VBZ	denotes	has
T7922	12618-12622	VBN	denotes	been
T7923	12623-12628	VBN	denotes	shown
T7924	12629-12631	TO	denotes	to
T7925	12632-12636	VB	denotes	have
T7926	12637-12638	DT	denotes	a
T7927	12639-12650	JJ	denotes	therapeutic
T7928	12651-12657	NN	denotes	effect
T7929	12658-12660	IN	denotes	on
T7930	12661-12673	JJ	denotes	experimental
T7931	12674-12677	NNP	denotes	ICH
T7932	12677-12678	,	denotes	,
T7933	12679-12683	JJ	denotes	such
T7934	12684-12686	IN	denotes	as
T7935	12687-12693	VB	denotes	reduce
T7936	12694-12706	NN	denotes	inflammation
T7937	12706-12707	,	denotes	,
T7938	12708-12718	JJ	denotes	behavioral
T7939	12719-12730	NN	denotes	dysfunction
T7940	12730-12731	,	denotes	,
T7941	12732-12735	CC	denotes	and
T7942	12736-12744	JJ	denotes	neuronal
T7943	12745-12751	NN	denotes	damage
T7944	12752-12760	VBN	denotes	produced
T7945	12761-12763	IN	denotes	by
T7946	12764-12767	NNP	denotes	ICH
T7947	12768-12769	NNP	denotes	[
T7948	12769-12771	CD	denotes	17
T7949	12771-12772	NNP	denotes	]
T7950	12772-12773	.	denotes	.
T7951	12774-12777	DT	denotes	The
T7952	12778-12787	NN	denotes	knowledge
T7953	12788-12793	IN	denotes	about
T7954	12794-12797	WRB	denotes	how
T7955	12798-12802	NNP	denotes	NFκB
T7956	12803-12805	VBZ	denotes	is
T7957	12806-12815	VBN	denotes	activated
T7958	12816-12818	IN	denotes	in
T7959	12819-12822	DT	denotes	the
T7960	12823-12828	NN	denotes	brain
T7961	12829-12838	VBN	denotes	subjected
T7962	12839-12841	TO	denotes	to
T7963	12842-12845	NNP	denotes	ICH
T7964	12846-12848	VBZ	denotes	is
T7965	12849-12857	JJ	denotes	critical
T7966	12858-12861	IN	denotes	for
T7967	12862-12869	VBG	denotes	seeking
T7968	12870-12871	DT	denotes	a
T7969	12872-12875	JJ	denotes	new
T7970	12876-12891	JJ	denotes	neuroprotective
T7971	12892-12898	NN	denotes	method
T7972	12899-12902	IN	denotes	for
T7973	12903-12906	NNP	denotes	ICH
T7974	12906-12907	.	denotes	.
T7975	12908-12917	JJ	denotes	Toll-like
T7976	12918-12927	NNS	denotes	receptors
T7977	12928-12929	-LRB-	denotes	(
T7978	12929-12933	NNS	denotes	TLRs
T7979	12933-12934	-RRB-	denotes	)
T7980	12935-12938	VBP	denotes	are
T7981	12939-12940	DT	denotes	a
T7982	12941-12947	NN	denotes	family
T7983	12948-12950	IN	denotes	of
T7984	12951-12957	NN	denotes	signal
T7985	12958-12970	NN	denotes	transduction
T7986	12971-12980	NNS	denotes	molecules
T7987	12981-12984	CC	denotes	and
T7988	12985-12989	VB	denotes	play
T7989	12990-12991	DT	denotes	a
T7990	12992-13000	JJ	denotes	critical
T7991	13001-13005	NN	denotes	role
T7992	13006-13008	IN	denotes	in
T7993	13009-13012	DT	denotes	the
T7994	13013-13022	NN	denotes	induction
T7995	13023-13025	IN	denotes	of
T7996	13026-13032	NN	denotes	innate
T7997	13033-13036	CC	denotes	and
T7998	13037-13045	JJ	denotes	adaptive
T7999	13046-13054	NN	denotes	immunity
T8000	13055-13056	NN	denotes	[
T8001	13056-13057	CD	denotes	4
T8002	13057-13058	NNP	denotes	]
T8003	13058-13059	.	denotes	.
T8004	13060-13072	JJ	denotes	TLR-mediated
T8005	13073-13082	VBG	denotes	signaling
T8006	13083-13091	NNS	denotes	pathways
T8007	13092-13098	RB	denotes	mainly
T8008	13099-13108	VBP	denotes	stimulate
T8009	13109-13112	DT	denotes	the
T8010	13113-13123	NN	denotes	activation
T8011	13124-13126	IN	denotes	of
T8012	13127-13131	NNP	denotes	NFκB
T8013	13132-13133	NNP	denotes	[
T8014	13133-13135	CD	denotes	12
T8015	13135-13136	,	denotes	,
T8016	13137-13139	CD	denotes	13
T8017	13139-13140	NN	denotes	]
T8018	13140-13141	.	denotes	.
T8019	13142-13146	CD	denotes	TLR4
T8020	13146-13147	,	denotes	,
T8021	13148-13151	DT	denotes	the
T8022	13152-13157	JJ	denotes	first
T8023	13158-13167	JJ	denotes	mammalian
T8024	13168-13171	NNP	denotes	TLR
T8025	13172-13182	VBD	denotes	recognized
T8026	13182-13183	,	denotes	,
T8027	13184-13187	VBZ	denotes	has
T8028	13188-13192	VBN	denotes	been
T8029	13193-13201	VBN	denotes	reported
T8030	13202-13204	TO	denotes	to
T8031	13205-13207	VB	denotes	be
T8032	13208-13216	VBN	denotes	involved
T8033	13217-13219	IN	denotes	in
T8034	13220-13227	JJ	denotes	several
T8035	13228-13235	JJ	denotes	central
T8036	13236-13243	JJ	denotes	nervous
T8037	13244-13245	-LRB-	denotes	(
T8038	13245-13248	NNP	denotes	CNS
T8039	13248-13249	-RRB-	denotes	)
T8040	13250-13256	NN	denotes	system
T8041	13257-13265	NNS	denotes	diseases
T8042	13265-13266	,	denotes	,
T8043	13267-13271	JJ	denotes	such
T8044	13272-13274	IN	denotes	as
T8045	13275-13287	JJ	denotes	inflammatory
T8046	13288-13290	CC	denotes	or
T8047	13291-13301	JJ	denotes	autoimmune
T8048	13302-13305	NNP	denotes	CNS
T8049	13306-13314	NNS	denotes	diseases
T8050	13315-13318	CC	denotes	and
T8051	13319-13327	JJ	denotes	cerebral
T8052	13328-13336	JJ	denotes	ischemic
T8053	13337-13343	NN	denotes	injury
T8054	13344-13345	NN	denotes	[
T8055	13345-13346	CD	denotes	7
T8056	13346-13347	,	denotes	,
T8057	13348-13349	CD	denotes	8
T8058	13349-13350	NN	denotes	]
T8059	13350-13351	.	denotes	.
T8060	13352-13360	IN	denotes	Although
T8061	13361-13369	JJ	denotes	previous
T8062	13370-13377	NNS	denotes	reports
T8063	13378-13387	VBD	denotes	indicated
T8064	13388-13392	IN	denotes	that
T8065	13393-13396	DT	denotes	the
T8066	13397-13407	NN	denotes	activation
T8067	13408-13410	IN	denotes	of
T8068	13411-13415	NNP	denotes	NFκB
T8069	13416-13419	VBD	denotes	was
T8070	13420-13430	VBN	denotes	attributed
T8071	13431-13433	TO	denotes	to
T8072	13434-13437	DT	denotes	the
T8073	13438-13447	JJ	denotes	oxidative
T8074	13448-13454	NN	denotes	stress
T8075	13455-13457	CC	denotes	or
T8076	13458-13467	NN	denotes	glutamate
T8077	13468-13476	NN	denotes	receptor
T8078	13477-13487	NN	denotes	activation
T8079	13488-13495	VBN	denotes	induced
T8080	13496-13498	IN	denotes	by
T8081	13499-13502	JJ	denotes	red
T8082	13503-13508	NN	denotes	blood
T8083	13509-13514	NNS	denotes	cells
T8084	13515-13521	CC	denotes	and/or
T8085	13522-13528	NN	denotes	plasma
T8086	13529-13541	NNS	denotes	constituents
T8087	13542-13543	NNP	denotes	[
T8088	13543-13545	CD	denotes	17
T8089	13545-13546	NNP	denotes	]
T8090	13546-13547	,	denotes	,
T8091	13548-13552	RB	denotes	very
T8092	13553-13556	JJ	denotes	few
T8093	13557-13564	NNS	denotes	studies
T8094	13565-13569	VBP	denotes	have
T8095	13570-13574	VBN	denotes	been
T8096	13575-13583	VBN	denotes	directed
T8097	13584-13586	TO	denotes	to
T8098	13587-13598	VB	denotes	investigate
T8099	13599-13602	DT	denotes	the
T8100	13603-13607	NN	denotes	role
T8101	13608-13611	CC	denotes	and
T8102	13612-13615	DT	denotes	the
T8103	13616-13628	NN	denotes	relationship
T8104	13629-13636	IN	denotes	between
T8105	13637-13650	JJ	denotes	TLR4-mediated
T8106	13651-13655	NNP	denotes	NFκB
T8107	13656-13665	VBG	denotes	signaling
T8108	13666-13669	CC	denotes	and
T8109	13670-13673	NNP	denotes	ICH
T8110	13673-13674	.	denotes	.
T8111	13675-13677	IN	denotes	In
T8112	13678-13681	DT	denotes	the
T8113	13682-13689	JJ	denotes	present
T8114	13690-13695	NN	denotes	study
T8115	13695-13696	,	denotes	,
T8116	13697-13699	PRP	denotes	we
T8117	13700-13711	VBD	denotes	established
T8118	13712-13715	DT	denotes	the
T8119	13716-13719	NN	denotes	rat
T8120	13720-13725	NN	denotes	model
T8121	13726-13728	IN	denotes	of
T8122	13729-13741	JJ	denotes	experimental
T8123	13742-13745	NNP	denotes	ICH
T8124	13746-13749	CC	denotes	and
T8125	13750-13758	VBD	denotes	detected
T8126	13759-13762	DT	denotes	the
T8127	13763-13767	CD	denotes	TLR4
T8128	13768-13772	NNP	denotes	mRNA
T8129	13773-13776	CC	denotes	and
T8130	13777-13784	NN	denotes	protein
T8131	13784-13785	.	denotes	.
T8132	13786-13789	PRP$	denotes	Our
T8133	13790-13794	NNS	denotes	data
T8134	13795-13801	VBD	denotes	showed
T8135	13802-13806	IN	denotes	that
T8136	13807-13820	NN	denotes	transcription
T8137	13821-13823	IN	denotes	of
T8138	13824-13828	CD	denotes	TLR4
T8139	13829-13831	RB	denotes	as
T8140	13832-13836	RB	denotes	well
T8141	13837-13839	IN	denotes	as
T8142	13840-13843	DT	denotes	the
T8143	13844-13854	NN	denotes	expression
T8144	13855-13857	IN	denotes	of
T8145	13858-13862	CD	denotes	TLR4
T8146	13863-13870	NN	denotes	protein
T8147	13871-13876	IN	denotes	after
T8148	13877-13880	NNP	denotes	ICH
T8149	13881-13894	RB	denotes	significantly
T8150	13895-13903	VBD	denotes	elevated
T8151	13904-13906	IN	denotes	in
T8152	13907-13912	NN	denotes	brain
T8153	13913-13919	NN	denotes	tissue
T8154	13919-13920	.	denotes	.
T8155	13921-13926	DT	denotes	These
T8156	13927-13934	NNS	denotes	changes
T8157	13935-13942	VBD	denotes	started
T8158	13943-13945	RB	denotes	as
T8159	13946-13951	JJ	denotes	early
T8160	13952-13954	IN	denotes	as
T8161	13955-13956	CD	denotes	6
T8162	13957-13962	NNS	denotes	hours
T8163	13963-13968	IN	denotes	after
T8164	13969-13972	DT	denotes	the
T8165	13973-13976	NNP	denotes	ICH
T8166	13977-13983	NN	denotes	insult
T8167	13984-13987	CC	denotes	and
T8168	13988-13998	VBD	denotes	maintained
T8169	13999-14001	IN	denotes	at
T8170	14002-14003	DT	denotes	a
T8171	14004-14008	JJ	denotes	high
T8172	14009-14014	NN	denotes	level
T8173	14015-14018	IN	denotes	for
T8174	14019-14020	CD	denotes	7
T8175	14021-14025	NNS	denotes	days
T8176	14026-14035	RB	denotes	afterward
T8177	14035-14036	.	denotes	.
T8178	14037-14040	DT	denotes	The
T8179	14041-14045	CD	denotes	TLR4
T8180	14046-14053	NN	denotes	protein
T8181	14053-14054	,	denotes	,
T8182	14055-14063	VBN	denotes	detected
T8183	14064-14066	IN	denotes	by
T8184	14067-14087	NN	denotes	immunohistochemistry
T8185	14087-14088	,	denotes	,
T8186	14089-14092	VBD	denotes	was
T8187	14093-14105	RB	denotes	consistently
T8188	14106-14117	VBN	denotes	distributed
T8189	14118-14120	IN	denotes	in
T8190	14121-14136	JJ	denotes	peri-hemorrhage
T8191	14137-14142	NNS	denotes	areas
T8192	14142-14143	,	denotes	,
T8193	14144-14147	DT	denotes	the
T8194	14148-14159	NN	denotes	hippocampus
T8195	14159-14160	,	denotes	,
T8196	14161-14167	NN	denotes	cortex
T8197	14167-14168	,	denotes	,
T8198	14169-14177	JJ	denotes	thalamic
T8199	14178-14184	NNS	denotes	nuclei
T8200	14184-14185	,	denotes	,
T8201	14186-14189	CC	denotes	and
T8202	14190-14194	DT	denotes	some
T8203	14195-14200	JJ	denotes	white
T8204	14201-14207	NN	denotes	matter
T8205	14208-14214	NNS	denotes	tracts
T8206	14214-14215	.	denotes	.
T8207	14216-14221	DT	denotes	These
T8208	14222-14226	NNS	denotes	data
T8209	14227-14236	VBD	denotes	indicated
T8210	14237-14241	IN	denotes	that
T8211	14242-14251	VBN	denotes	increased
T8212	14252-14262	NN	denotes	expression
T8213	14263-14265	IN	denotes	of
T8214	14266-14270	CD	denotes	TLR4
T8215	14271-14274	MD	denotes	may
T8216	14275-14277	VB	denotes	be
T8217	14278-14285	VBN	denotes	related
T8218	14286-14288	TO	denotes	to
T8219	14289-14292	DT	denotes	the
T8220	14293-14303	VBG	denotes	triggering
T8221	14304-14306	IN	denotes	of
T8222	14307-14310	DT	denotes	the
T8223	14311-14323	JJ	denotes	inflammatory
T8224	14324-14333	NNS	denotes	responses
T8225	14334-14336	IN	denotes	in
T8226	14337-14340	DT	denotes	the
T8227	14341-14346	NN	denotes	brain
T8228	14347-14353	NN	denotes	tissue
T8229	14354-14359	IN	denotes	after
T8230	14360-14363	NNP	denotes	ICH
T8231	14363-14364	.	denotes	.
T8232	14365-14371	JJ	denotes	Recent
T8233	14372-14379	NNS	denotes	studies
T8234	14380-14392	VBD	denotes	demonstrated
T8235	14393-14397	IN	denotes	that
T8236	14398-14401	NNP	denotes	ICH
T8237	14402-14411	VBZ	denotes	initiates
T8238	14412-14424	JJ	denotes	inflammatory
T8239	14425-14434	NNS	denotes	responses
T8240	14434-14435	,	denotes	,
T8241	14436-14441	WDT	denotes	which
T8242	14442-14445	VBP	denotes	are
T8243	14446-14456	VBN	denotes	associated
T8244	14457-14461	IN	denotes	with
T8245	14462-14471	JJ	denotes	secondary
T8246	14472-14478	NN	denotes	growth
T8247	14479-14481	IN	denotes	of
T8248	14482-14492	NN	denotes	hemorrhage
T8249	14493-14496	CC	denotes	and
T8250	14497-14501	NN	denotes	cell
T8251	14502-14507	NN	denotes	death
T8252	14508-14509	NNP	denotes	[
T8253	14509-14511	CD	denotes	18
T8254	14511-14512	NNP	denotes	]
T8255	14512-14513	.	denotes	.
T8256	14514-14516	PRP	denotes	It
T8257	14517-14519	VBZ	denotes	is
T8258	14520-14523	RB	denotes	now
T8259	14524-14532	VBN	denotes	believed
T8260	14533-14537	IN	denotes	that
T8261	14538-14556	JJ	denotes	TLR4-mediated-NFκB
T8262	14557-14564	NN	denotes	pathway
T8263	14565-14574	NNS	denotes	activates
T8264	14575-14578	CC	denotes	and
T8265	14579-14588	VBZ	denotes	regulates
T8266	14589-14602	JJ	denotes	immunological
T8267	14603-14606	CC	denotes	and
T8268	14607-14619	JJ	denotes	inflammatory
T8269	14620-14629	NNS	denotes	responses
T8270	14629-14630	.	denotes	.
T8271	14631-14633	TO	denotes	To
T8272	14634-14645	VB	denotes	investigate
T8273	14646-14649	DT	denotes	the
T8274	14650-14660	NNS	denotes	mechanisms
T8275	14661-14671	VBG	denotes	underlying
T8276	14672-14675	DT	denotes	the
T8277	14676-14685	VBN	denotes	increased
T8278	14686-14698	JJ	denotes	inflammatory
T8279	14699-14708	NNS	denotes	responses
T8280	14709-14711	IN	denotes	in
T8281	14712-14715	DT	denotes	the
T8282	14716-14721	NN	denotes	brain
T8283	14722-14727	IN	denotes	after
T8284	14728-14731	NNP	denotes	ICH
T8285	14731-14732	,	denotes	,
T8286	14733-14735	IN	denotes	in
T8287	14736-14739	DT	denotes	the
T8288	14740-14747	JJ	denotes	present
T8289	14748-14753	NN	denotes	study
T8290	14753-14754	,	denotes	,
T8291	14755-14757	PRP	denotes	we
T8292	14758-14767	VBD	denotes	evaluated
T8293	14768-14771	DT	denotes	the
T8294	14772-14782	NN	denotes	activation
T8295	14783-14785	IN	denotes	of
T8296	14786-14799	JJ	denotes	TLR4-mediated
T8297	14800-14804	NNP	denotes	NFκB
T8298	14805-14814	VBG	denotes	signaling
T8299	14815-14817	IN	denotes	by
T8300	14818-14827	VBG	denotes	detecting
T8301	14828-14831	DT	denotes	the
T8302	14832-14837	NN	denotes	p-IκB
T8303	14838-14841	CC	denotes	and
T8304	14842-14845	DT	denotes	the
T8305	14846-14854	NN	denotes	activity
T8306	14855-14857	IN	denotes	of
T8307	14858-14862	NNP	denotes	NFκB
T8308	14863-14865	IN	denotes	in
T8309	14866-14877	JJ	denotes	hemorrhagic
T8310	14878-14884	NNS	denotes	brains
T8311	14884-14885	.	denotes	.
T8312	14886-14890	NNP	denotes	NFκB
T8313	14891-14893	VBZ	denotes	is
T8314	14894-14896	DT	denotes	an
T8315	14897-14906	JJ	denotes	important
T8316	14907-14920	NN	denotes	transcription
T8317	14921-14927	NN	denotes	factor
T8318	14928-14938	JJ	denotes	downstream
T8319	14939-14941	IN	denotes	in
T8320	14942-14945	DT	denotes	the
T8321	14946-14959	JJ	denotes	TLR4-mediated
T8322	14960-14969	VBG	denotes	signaling
T8323	14970-14977	NN	denotes	pathway
T8324	14977-14978	.	denotes	.
T8325	14979-14989	NNP	denotes	Activation
T8326	14990-14992	IN	denotes	of
T8327	14993-14997	CD	denotes	TLR4
T8328	14998-15008	NNS	denotes	stimulates
T8329	15009-15013	NNP	denotes	IκBα
T8330	15014-15029	NN	denotes	phosphorylation
T8331	15030-15033	CC	denotes	and
T8332	15034-15045	NN	denotes	degradation
T8333	15045-15046	,	denotes	,
T8334	15047-15056	VBG	denotes	resulting
T8335	15057-15059	IN	denotes	in
T8336	15060-15067	JJ	denotes	nuclear
T8337	15068-15081	NN	denotes	translocation
T8338	15082-15084	IN	denotes	of
T8339	15085-15089	NNP	denotes	NFκB
T8340	15089-15090	,	denotes	,
T8341	15091-15096	WDT	denotes	which
T8342	15097-15106	VBZ	denotes	initiates
T8343	15107-15120	NN	denotes	transcription
T8344	15121-15123	IN	denotes	of
T8345	15124-15129	NNS	denotes	genes
T8346	15130-15140	VBN	denotes	associated
T8347	15141-15145	IN	denotes	with
T8348	15146-15152	JJ	denotes	innate
T8349	15153-15159	JJ	denotes	immune
T8350	15160-15169	NNS	denotes	responses
T8351	15170-15173	CC	denotes	and
T8352	15174-15186	NN	denotes	inflammation
T8353	15187-15188	NN	denotes	[
T8354	15188-15189	CD	denotes	5
T8355	15189-15190	,	denotes	,
T8356	15191-15192	CD	denotes	6
T8357	15192-15193	NN	denotes	]
T8358	15193-15194	.	denotes	.
T8359	15195-15197	PRP	denotes	We
T8360	15198-15206	VBD	denotes	observed
T8361	15207-15211	IN	denotes	that
T8362	15212-15215	DT	denotes	the
T8363	15216-15222	NNS	denotes	levels
T8364	15223-15225	IN	denotes	of
T8365	15226-15241	NN	denotes	phosphorylation
T8366	15242-15244	IN	denotes	of
T8367	15245-15248	NNP	denotes	IκB
T8368	15249-15252	CC	denotes	and
T8369	15253-15256	DT	denotes	the
T8370	15257-15265	NN	denotes	activity
T8371	15266-15268	IN	denotes	of
T8372	15269-15273	NNP	denotes	NFκB
T8373	15274-15278	VBD	denotes	were
T8374	15279-15292	RB	denotes	significantly
T8375	15293-15302	VBN	denotes	increased
T8376	15303-15305	IN	denotes	in
T8377	15306-15311	NN	denotes	brain
T8378	15312-15318	NN	denotes	tissue
T8379	15319-15324	IN	denotes	after
T8380	15325-15328	NNP	denotes	ICH
T8381	15328-15329	.	denotes	.
T8382	15330-15333	DT	denotes	The
T8383	15334-15342	JJ	denotes	temporal
T8384	15343-15350	NN	denotes	profile
T8385	15351-15353	IN	denotes	of
T8386	15354-15357	DT	denotes	the
T8387	15358-15368	NN	denotes	expression
T8388	15369-15371	IN	denotes	of
T8389	15372-15377	NN	denotes	p-IκB
T8390	15378-15381	CC	denotes	and
T8391	15382-15385	DT	denotes	the
T8392	15386-15396	NN	denotes	activation
T8393	15397-15399	IN	denotes	of
T8394	15400-15404	NNP	denotes	NFκB
T8395	15405-15408	VBD	denotes	was
T8396	15409-15416	JJ	denotes	similar
T8397	15417-15419	TO	denotes	to
T8398	15420-15424	DT	denotes	that
T8399	15425-15427	IN	denotes	of
T8400	15428-15431	DT	denotes	the
T8401	15432-15442	NN	denotes	expression
T8402	15443-15445	IN	denotes	of
T8403	15446-15450	CD	denotes	TLR4
T8404	15450-15451	.	denotes	.
T8405	15452-15455	PRP$	denotes	Our
T8406	15456-15460	NNS	denotes	data
T8407	15461-15468	VBP	denotes	suggest
T8408	15469-15473	IN	denotes	that
T8409	15474-15477	NNP	denotes	ICH
T8410	15478-15488	VBZ	denotes	stimulates
T8411	15489-15499	NN	denotes	activation
T8412	15500-15502	IN	denotes	of
T8413	15503-15506	DT	denotes	the
T8414	15507-15514	CD	denotes	TLR4/NF
T8415	15514-15516	NN	denotes	κB
T8416	15517-15526	VBG	denotes	signaling
T8417	15527-15534	NN	denotes	pathway
T8418	15534-15535	,	denotes	,
T8419	15536-15541	WDT	denotes	which
T8420	15542-15544	VBZ	denotes	is
T8421	15545-15555	JJ	denotes	consistent
T8422	15556-15560	IN	denotes	with
T8423	15561-15569	JJ	denotes	previous
T8424	15570-15577	NNS	denotes	reports
T8425	15578-15582	IN	denotes	that
T8426	15583-15593	NN	denotes	activation
T8427	15594-15596	IN	denotes	of
T8428	15597-15601	NNP	denotes	NFκB
T8429	15602-15604	VBZ	denotes	is
T8430	15605-15614	VBN	denotes	regulated
T8431	15615-15622	IN	denotes	through
T8432	15623-15626	DT	denotes	the
T8433	15627-15640	JJ	denotes	TLR4-mediated
T8434	15641-15650	VBG	denotes	signaling
T8435	15651-15658	NN	denotes	pathway
T8436	15658-15659	.	denotes	.
T8437	15660-15664	CD	denotes	TLR4
T8438	15665-15670	VBZ	denotes	plays
T8439	15671-15673	DT	denotes	an
T8440	15674-15683	JJ	denotes	important
T8441	15684-15688	NN	denotes	role
T8442	15689-15691	IN	denotes	in
T8443	15692-15695	DT	denotes	the
T8444	15696-15707	NN	denotes	recognition
T8445	15708-15710	IN	denotes	of
T8446	15711-15720	JJ	denotes	microbial
T8447	15721-15731	NNS	denotes	components
T8448	15732-15733	NNP	denotes	[
T8449	15733-15735	CD	denotes	19
T8450	15735-15736	,	denotes	,
T8451	15737-15739	CD	denotes	20
T8452	15739-15740	NN	denotes	]
T8453	15741-15744	CC	denotes	and
T8454	15745-15748	MD	denotes	can
T8455	15749-15753	RB	denotes	also
T8456	15754-15763	VB	denotes	recognize
T8457	15764-15774	JJ	denotes	endogenous
T8458	15775-15784	NNS	denotes	molecules
T8459	15785-15789	JJ	denotes	such
T8460	15790-15792	IN	denotes	as
T8461	15793-15796	DT	denotes	the
T8462	15797-15808	NN	denotes	degradation
T8463	15809-15817	NNS	denotes	products
T8464	15818-15820	IN	denotes	of
T8465	15821-15835	NNS	denotes	macromolecules
T8466	15835-15836	,	denotes	,
T8467	15837-15845	NNS	denotes	products
T8468	15846-15848	IN	denotes	of
T8469	15849-15860	JJ	denotes	proteolytic
T8470	15861-15869	NNS	denotes	cascades
T8471	15869-15870	,	denotes	,
T8472	15871-15884	JJ	denotes	intracellular
T8473	15885-15895	NNS	denotes	components
T8474	15896-15898	IN	denotes	of
T8475	15899-15907	VBN	denotes	ruptured
T8476	15908-15913	NNS	denotes	cells
T8477	15913-15914	,	denotes	,
T8478	15915-15918	CC	denotes	and
T8479	15919-15927	NNS	denotes	products
T8480	15928-15930	IN	denotes	of
T8481	15931-15936	NNS	denotes	genes
T8482	15937-15941	WDT	denotes	that
T8483	15942-15945	VBP	denotes	are
T8484	15946-15955	VBN	denotes	activated
T8485	15956-15958	IN	denotes	by
T8486	15959-15971	NN	denotes	inflammation
T8487	15971-15972	.	denotes	.
T8488	15973-15976	IN	denotes	For
T8489	15977-15985	NN	denotes	instance
T8490	15985-15986	,	denotes	,
T8491	15987-15992	NNP	denotes	HSP70
T8492	15992-15993	,	denotes	,
T8493	15994-15999	NNP	denotes	HSP32
T8494	15999-16000	,	denotes	,
T8495	16001-16006	NNP	denotes	HSP27
T8496	16006-16007	,	denotes	,
T8497	16008-16011	CC	denotes	and
T8498	16012-16019	VBZ	denotes	enzymes
T8499	16020-16028	VBN	denotes	involved
T8500	16029-16031	IN	denotes	in
T8501	16032-16041	JJ	denotes	oxidative
T8502	16042-16048	NN	denotes	stress
T8503	16049-16052	VBP	denotes	are
T8504	16053-16058	VBN	denotes	found
T8505	16059-16061	TO	denotes	to
T8506	16062-16064	VB	denotes	be
T8507	16065-16076	VBN	denotes	upregulated
T8508	16077-16079	IN	denotes	in
T8509	16080-16083	DT	denotes	the
T8510	16084-16089	NN	denotes	brain
T8511	16090-16095	IN	denotes	after
T8512	16096-16099	NNP	denotes	ICH
T8513	16099-16100	,	denotes	,
T8514	16101-16106	WDT	denotes	which
T8515	16107-16110	MD	denotes	may
T8516	16111-16113	VB	denotes	be
T8517	16114-16122	VBN	denotes	produced
T8518	16123-16125	IN	denotes	by
T8519	16126-16133	JJ	denotes	injured
T8520	16134-16142	JJ	denotes	neuronal
T8521	16143-16148	NNS	denotes	cells
T8522	16149-16151	CC	denotes	or
T8523	16152-16157	NN	denotes	blood
T8524	16158-16163	NNS	denotes	cells
T8525	16164-16165	NNP	denotes	[
T8526	16165-16167	CD	denotes	21
T8527	16167-16168	NNP	denotes	]
T8528	16168-16169	.	denotes	.
T8529	16170-16172	PRP	denotes	It
T8530	16173-16176	MD	denotes	may
T8531	16177-16179	VB	denotes	be
T8532	16180-16190	VBN	denotes	speculated
T8533	16191-16195	IN	denotes	that
T8534	16196-16201	DT	denotes	these
T8535	16202-16211	NNS	denotes	molecules
T8536	16212-16220	VBN	denotes	produced
T8537	16221-16223	IN	denotes	in
T8538	16224-16231	JJ	denotes	damaged
T8539	16232-16237	NN	denotes	brain
T8540	16238-16240	CC	denotes	or
T8541	16241-16245	VBD	denotes	came
T8542	16246-16250	IN	denotes	from
T8543	16251-16256	NN	denotes	blood
T8544	16257-16262	NNS	denotes	cells
T8545	16263-16266	CC	denotes	and
T8546	16267-16279	NNS	denotes	constituents
T8547	16280-16282	IN	denotes	of
T8548	16283-16289	NN	denotes	plasma
T8549	16290-16296	NN	denotes	server
T8550	16297-16299	IN	denotes	as
T8551	16300-16310	JJ	denotes	endogenous
T8552	16311-16315	CD	denotes	TLR4
T8553	16316-16323	NNS	denotes	ligands
T8554	16323-16324	,	denotes	,
T8555	16325-16333	VBP	denotes	activate
T8556	16334-16347	JJ	denotes	TLR4-mediated
T8557	16348-16352	NNP	denotes	NFκB
T8558	16353-16362	VBG	denotes	signaling
T8559	16362-16363	,	denotes	,
T8560	16364-16367	CC	denotes	and
T8561	16368-16376	VB	denotes	initiate
T8562	16377-16380	DT	denotes	the
T8563	16381-16393	JJ	denotes	inflammatory
T8564	16394-16403	NNS	denotes	responses
T8565	16404-16406	IN	denotes	in
T8566	16407-16410	NNP	denotes	IHC
T8567	16411-16416	NN	denotes	brain
T8568	16416-16417	.	denotes	.
T8569	16418-16425	RB	denotes	However
T8570	16425-16426	,	denotes	,
T8571	16427-16430	DT	denotes	the
T8572	16431-16439	JJ	denotes	specific
T8573	16440-16450	JJ	denotes	endogenous
T8574	16451-16458	NNS	denotes	ligands
T8575	16459-16462	IN	denotes	for
T8576	16463-16467	CD	denotes	TLR4
T8577	16468-16470	IN	denotes	in
T8578	16471-16482	JJ	denotes	hemorrhagic
T8579	16483-16488	NN	denotes	brain
T8580	16489-16493	VBP	denotes	have
T8581	16494-16497	RB	denotes	not
T8582	16498-16502	VBN	denotes	been
T8583	16503-16513	VBN	denotes	determined
T8584	16514-16517	CC	denotes	and
T8585	16518-16522	VBP	denotes	need
T8586	16523-16525	TO	denotes	to
T8587	16526-16528	VB	denotes	be
T8588	16529-16539	VBN	denotes	identified
T8589	16540-16547	IN	denotes	through
T8590	16548-16555	JJ	denotes	further
T8591	16556-16564	NN	denotes	research
T8592	16564-16565	.	denotes	.
T8593	16566-16568	IN	denotes	In
T8594	16569-16579	NN	denotes	conclusion
T8595	16579-16580	,	denotes	,
T8596	16581-16584	DT	denotes	the
T8597	16585-16592	JJ	denotes	present
T8598	16593-16598	NN	denotes	study
T8599	16599-16611	VBD	denotes	demonstrated
T8600	16612-16615	DT	denotes	the
T8601	16616-16624	JJ	denotes	temporal
T8602	16625-16632	NN	denotes	profile
T8603	16633-16635	IN	denotes	of
T8604	16636-16639	DT	denotes	the
T8605	16640-16650	NN	denotes	activation
T8606	16651-16653	IN	denotes	of
T8607	16654-16667	JJ	denotes	TLR4-mediated
T8608	16668-16672	NNP	denotes	NFκB
T8609	16673-16682	VBG	denotes	signaling
T8610	16683-16685	IN	denotes	in
T8611	16686-16691	NN	denotes	brain
T8612	16692-16698	NN	denotes	tissue
T8613	16699-16701	IN	denotes	in
T8614	16702-16703	DT	denotes	a
T8615	16704-16707	NN	denotes	rat
T8616	16708-16713	NN	denotes	model
T8617	16714-16716	IN	denotes	of
T8618	16717-16729	JJ	denotes	experimental
T8619	16730-16733	NNP	denotes	ICH
T8620	16733-16734	,	denotes	,
T8621	16735-16740	WDT	denotes	which
T8622	16741-16749	VBZ	denotes	suggests
T8623	16750-16754	IN	denotes	that
T8624	16755-16768	JJ	denotes	TLR4-mediated
T8625	16769-16773	NNP	denotes	NFκB
T8626	16774-16783	VBG	denotes	signaling
T8627	16784-16796	VBZ	denotes	participates
T8628	16797-16799	IN	denotes	in
T8629	16800-16803	DT	denotes	the
T8630	16804-16816	NN	denotes	pathogenesis
T8631	16817-16819	IN	denotes	of
T8632	16820-16823	NNP	denotes	ICH
T8633	16823-16824	,	denotes	,
T8634	16825-16830	WDT	denotes	which
T8635	16831-16834	MD	denotes	may
T8636	16835-16837	VB	denotes	be
T8637	16838-16839	DT	denotes	a
T8638	16840-16851	JJ	denotes	therapeutic
T8639	16852-16858	NN	denotes	target
T8640	16859-16862	IN	denotes	for
T8641	16863-16866	DT	denotes	the
T8642	16867-16877	NN	denotes	prevention
T8643	16878-16880	IN	denotes	of
T8644	16881-16892	JJ	denotes	ICH-induced
T8645	16893-16898	NN	denotes	brain
T8646	16899-16905	NN	denotes	damage
T8647	16905-16906	.	denotes	.
R1000	T1361	T1360	prep	following,damage
R1001	T1362	T1363	compound	ICH,[
R1002	T1363	T1365	nmod	[,]
R1003	T1364	T1365	nummod	3,]
R1004	T1365	T1361	pobj	],following
R1005	T1366	T1334	punct	.,induces
R1006	T1367	T1368	preconj	Both,innate
R1007	T1368	T1376	nsubjpass	innate,shown
R1008	T1369	T1368	cc	and,innate
R1009	T1370	T1372	amod	adaptive,mechanisms
R1010	T1371	T1372	amod	immunological/inflammatory,mechanisms
R1011	T1372	T1368	conj	mechanisms,innate
R1012	T1373	T1376	aux	have,shown
R1013	T1374	T1376	auxpass	been,shown
R1014	T1375	T1376	advmod	clearly,shown
R1015	T1376	T1376	ROOT	shown,shown
R1016	T1377	T1378	aux	to,participate
R1017	T1378	T1376	xcomp	participate,shown
R1018	T1379	T1378	prep	in,participate
R1019	T1380	T1381	det	the,progression
R1020	T1381	T1379	pobj	progression,in
R1021	T1382	T1381	prep	of,progression
R1022	T1383	T1384	compound	brain,injury
R1023	T1384	T1382	pobj	injury,of
R1024	T1385	T1378	prep	after,participate
R1025	T1386	T1387	amod	ischemic,stroke
R1026	T1387	T1385	pobj	stroke,after
R1027	T1388	T1376	punct	.,shown
R1028	T1389	T1398	advmod	Nevertheless,triggered
R1029	T1390	T1398	punct	",",triggered
R1030	T1391	T1398	advmod	how,triggered
R1031	T1392	T1394	det	the,responses
R1032	T1393	T1394	amod	inflammatory,responses
R1033	T1394	T1398	nsubjpass	responses,triggered
R1034	T1395	T1394	prep	in,responses
R1035	T1396	T1395	pobj	ICH,in
R1036	T1397	T1398	auxpass	are,triggered
R1037	T1398	T1398	ROOT	triggered,triggered
R1038	T1399	T1398	cc	and,triggered
R1039	T1400	T1398	conj	regulated,triggered
R1040	T1401	T1398	conj	remains,triggered
R1041	T1402	T1404	aux	to,elucidated
R1042	T1403	T1404	auxpass	be,elucidated
R1043	T1404	T1401	xcomp	elucidated,remains
R1044	T1405	T1398	punct	.,triggered
R1045	T1406	T1407	nsubj	TLRs,are
R1046	T1407	T1407	ROOT	are,are
R1047	T1408	T1409	det	a,family
R1048	T1409	T1407	attr	family,are
R1049	T1410	T1409	prep	of,family
R1050	T1411	T1412	compound	transmembrane,proteins
R1051	T1412	T1410	pobj	proteins,of
R1052	T1413	T1409	cc	and,family
R1053	T1414	T1409	conj	act,family
R1054	T1415	T1419	mark	as,[
R1055	T1416	T1418	compound	signal,molecules
R1056	T1417	T1418	compound	transduction,molecules
R1057	T1418	T1419	nsubj	molecules,[
R1058	T1419	T1407	advcl	[,are
R1059	T1420	T1421	nummod	4,]
R1060	T1421	T1419	dobj	],[
R1061	T1422	T1407	punct	.,are
R1062	T1423	T1426	nsubj	Activation,recruits
R1063	T1424	T1423	prep	of,Activation
R1064	T1425	T1424	pobj	TLRs,of
R1065	T1426	T1426	ROOT	recruits,recruits
R1066	T1427	T1429	amod	downstream,proteins
R1067	T1428	T1429	amod	signaling,proteins
R1068	T1429	T1426	dobj	proteins,recruits
R1069	T1430	T1429	cc	and,proteins
R1070	T1431	T1429	conj	results,proteins
R1071	T1432	T1431	prep	in,results
R1072	T1433	T1432	pobj	transcription,in
R1073	T1434	T1433	prep	of,transcription
R1074	T1435	T1434	pobj	genes,of
R1075	T1436	T1435	acl	encoding,genes
R1076	T1437	T1438	amod	inflammation-associated,molecules
R1077	T1438	T1436	dobj	molecules,encoding
R1078	T1439	T1438	cc	and,molecules
R1079	T1440	T1438	conj	cytokines,molecules
R1080	T1441	T1445	nmod	[,]
R1081	T1442	T1441	nummod	5,[
R1082	T1443	T1444	punct	",",6
R1083	T1444	T1445	nummod	6,]
R1084	T1445	T1426	npadvmod	],recruits
R1085	T1446	T1426	punct	.,recruits
R1086	T1447	T1459	prep	For,induces
R1087	T1448	T1447	pobj	example,For
R1088	T1449	T1459	punct	",",induces
R1089	T1450	T1459	advcl	combined,induces
R1090	T1451	T1450	prep	with,combined
R1091	T1452	T1453	amod	specific,ligand
R1092	T1453	T1451	pobj	ligand,with
R1093	T1454	T1453	punct	",",ligand
R1094	T1455	T1456	det	the,activation
R1095	T1456	T1459	nsubj	activation,induces
R1096	T1457	T1456	prep	of,activation
R1097	T1458	T1457	pobj	TLR4,of
R1098	T1459	T1459	ROOT	induces,induces
R1099	T1460	T1461	det	the,phosphorylation
R1100	T1461	T1459	dobj	phosphorylation,induces
R1101	T1462	T1461	prep	of,phosphorylation
R1102	T1463	T1462	pobj	inhibitor,of
R1103	T1464	T1463	prep	of,inhibitor
R1104	T1465	T1464	pobj	kappa-B,of
R1105	T1466	T1465	punct	(,kappa-B
R1106	T1467	T1465	appos	IκB,kappa-B
R1107	T1468	T1465	punct	),kappa-B
R1108	T1469	T1459	cc	and,induces
R1109	T1470	T1459	conj	dissociates,induces
R1110	T1471	T1470	dobj	IκB,dissociates
R1111	T1472	T1471	prep	from,IκB
R1112	T1473	T1472	pobj	NF-kappa-B,from
R1113	T1474	T1473	punct	(,NF-kappa-B
R1114	T1475	T1473	appos	NFκB,NF-kappa-B
R1115	T1476	T1473	punct	),NF-kappa-B
R1116	T1477	T1459	punct	.,induces
R1117	T1478	T1481	advmod	Then,trans-locates
R1118	T1479	T1481	punct	",",trans-locates
R1119	T1480	T1481	nsubj	NFκB,trans-locates
R1120	T1481	T1481	ROOT	trans-locates,trans-locates
R1121	T1482	T1481	prep	into,trans-locates
R1122	T1483	T1484	det	the,nucleus
R1123	T1484	T1482	pobj	nucleus,into
R1124	T1485	T1481	cc	and,trans-locates
R1125	T1486	T1481	conj	activates,trans-locates
R1126	T1487	T1486	cc	and,activates
R1127	T1488	T1486	conj	regulates,activates
R1128	T1489	T1490	det	the,transcription
R1129	T1490	T1488	dobj	transcription,regulates
R1130	T1491	T1490	prep	of,transcription
R1131	T1492	T1491	pobj	genes,of
R1132	T1493	T1492	acl	related,genes
R1133	T1494	T1493	prep	to,related
R1134	T1495	T1496	amod	inflammatory,responses
R1135	T1496	T1494	pobj	responses,to
R1136	T1497	T1496	amod	[,responses
R1137	T1498	T1501	nummod	5,]
R1138	T1499	T1500	punct	",",6
R1139	T1500	T1501	nummod	6,]
R1140	T1501	T1497	appos	],[
R1141	T1502	T1486	punct	.,activates
R1142	T1503	T1504	nsubj	TLRs,play
R1143	T1504	T1504	ROOT	play,play
R1144	T1505	T1507	det	a,role
R1145	T1506	T1507	amod	critical,role
R1146	T1507	T1504	dobj	role,play
R1147	T1508	T1504	prep	in,play
R1148	T1509	T1510	det	the,induction
R1149	T1510	T1508	pobj	induction,in
R1150	T1511	T1510	prep	of,induction
R1151	T1512	T1513	amod	immunological/inflammatory,responses
R1152	T1513	T1511	pobj	responses,of
R1153	T1514	T1504	cc	and,play
R1154	T1515	T1516	auxpass	are,implicated
R1155	T1516	T1504	conj	implicated,play
R1156	T1517	T1516	prep	in,implicated
R1157	T1518	T1520	amod	several,diseases
R1158	T1519	T1520	compound	CNS,diseases
R1159	T1520	T1517	pobj	diseases,in
R1160	T1521	T1520	punct	",",diseases
R1161	T1522	T1523	amod	such,as
R1162	T1523	T1520	prep	as,diseases
R1163	T1524	T1525	amod	infectious,disease
R1164	T1525	T1523	pobj	disease,as
R1165	T1526	T1525	punct	",",disease
R1166	T1527	T1528	amod	autoimmune,disease
R1167	T1528	T1525	conj	disease,disease
R1168	T1529	T1528	punct	",",disease
R1169	T1530	T1528	cc	and,disease
R1170	T1531	T1534	amod	ischemic,[
R1171	T1532	T1533	compound	brain,injury
R1172	T1533	T1534	compound	injury,[
R1173	T1534	T1528	conj	[,disease
R1174	T1535	T1534	nummod	7,[
R1175	T1536	T1534	punct	",",[
R1176	T1537	T1538	nummod	8,]
R1177	T1538	T1534	appos	],[
R1178	T1539	T1504	punct	.,play
R1179	T1540	T1541	amod	Accumulating,evidences
R1180	T1541	T1542	nsubj	evidences,demonstrate
R1181	T1542	T1542	ROOT	demonstrate,demonstrate
R1182	T1543	T1552	mark	that,contributes
R1183	T1544	T1552	nsubj	TLR4,contributes
R1184	T1545	T1544	punct	",",TLR4
R1185	T1546	T1550	det	the,recognized
R1186	T1547	T1550	amod	first,recognized
R1187	T1548	T1550	npadvmod	mammalian,recognized
R1188	T1549	T1550	nsubj	TLR,recognized
R1189	T1550	T1552	nsubj	recognized,contributes
R1190	T1551	T1552	punct	",",contributes
R1191	T1552	T1542	ccomp	contributes,demonstrate
R1192	T1553	T1552	prep	to,contributes
R1193	T1554	T1556	det	the,death
R1194	T1555	T1556	amod	neuronal,death
R1195	T1556	T1553	pobj	death,to
R1196	T1557	T1556	punct	",",death
R1197	T1558	T1559	compound	blood,brain
R1198	T1559	T1561	compound	brain,damage
R1199	T1560	T1561	compound	barrier,damage
R1200	T1561	T1556	appos	damage,death
R1201	T1562	T1561	punct	",",damage
R1202	T1563	T1564	compound	brain,edema
R1203	T1564	T1561	conj	edema,damage
R1204	T1565	T1564	punct	",",edema
R1205	T1566	T1564	cc	and,edema
R1206	T1567	T1568	amod	inflammatory,responses
R1207	T1568	T1564	conj	responses,edema
R1208	T1569	T1568	prep	in,responses
R1209	T1570	T1572	det	the,injury
R1210	T1571	T1572	compound	brain,injury
R1211	T1572	T1569	pobj	injury,in
R1212	T1573	T1572	acl	induced,injury
R1213	T1574	T1573	agent	by,induced
R1214	T1575	T1576	compound	ischemia,[
R1215	T1576	T1580	nmod	[,]
R1216	T1577	T1576	nummod	8,[
R1217	T1578	T1580	punct	",",]
R1218	T1579	T1580	nummod	9,]
R1219	T1580	T1561	appos	],damage
R1220	T1581	T1542	punct	.,demonstrate
R1221	T1582	T1586	advmod	However,known
R1222	T1583	T1586	punct	",",known
R1223	T1584	T1586	advmod	little,known
R1224	T1585	T1586	auxpass	is,known
R1225	T1586	T1586	ROOT	known,known
R1226	T1587	T1586	prep	about,known
R1227	T1588	T1587	pobj	TLR4,about
R1228	T1589	T1588	prep	in,TLR4
R1229	T1590	T1591	det	the,brain
R1230	T1591	T1589	pobj	brain,in
R1231	T1592	T1586	prep	after,known
R1232	T1593	T1592	pobj	ICH,after
R1233	T1594	T1586	punct	.,known
R1234	T1595	T1601	prep	In,detected
R1235	T1596	T1598	det	the,study
R1236	T1597	T1598	amod	present,study
R1237	T1598	T1595	pobj	study,In
R1238	T1599	T1601	punct	",",detected
R1239	T1600	T1601	nsubj	we,detected
R1240	T1601	T1601	ROOT	detected,detected
R1241	T1602	T1603	det	the,transcription
R1242	T1603	T1601	dobj	transcription,detected
R1243	T1604	T1603	prep	of,transcription
R1244	T1605	T1606	nummod	TLR4,gene
R1245	T1606	T1604	pobj	gene,of
R1246	T1607	T1603	cc	and,transcription
R1247	T1608	T1609	det	the,activation
R1248	T1609	T1603	conj	activation,transcription
R1249	T1610	T1609	prep	of,activation
R1250	T1611	T1612	amod	TLR4-mediated,signaling
R1251	T1612	T1610	pobj	signaling,of
R1252	T1613	T1609	prep	in,activation
R1253	T1614	T1616	det	the,brains
R1254	T1615	T1616	compound	rat,brains
R1255	T1616	T1613	pobj	brains,in
R1256	T1617	T1603	acl	subjected,transcription
R1257	T1618	T1617	prep	to,subjected
R1258	T1619	T1620	amod	experimental,ICH
R1259	T1620	T1618	pobj	ICH,to
R1260	T1621	T1601	punct	.,detected
R1261	T1622	T1623	poss	Our,data
R1262	T1623	T1625	nsubj	data,provided
R1263	T1624	T1625	advmod	firstly,provided
R1264	T1625	T1625	ROOT	provided,provided
R1265	T1626	T1627	det	the,knowledge
R1266	T1627	T1625	dobj	knowledge,provided
R1267	T1628	T1627	prep	about,knowledge
R1268	T1629	T1630	det	the,distribution
R1269	T1630	T1628	pobj	distribution,about
R1270	T1631	T1630	prep	of,distribution
R1271	T1632	T1631	pobj	TLR4,of
R1272	T1633	T1630	cc	and,distribution
R1273	T1634	T1636	det	the,profile
R1274	T1635	T1636	amod	temporal,profile
R1275	T1636	T1630	conj	profile,distribution
R1276	T1637	T1636	prep	of,profile
R1277	T1638	T1639	det	the,activation
R1278	T1639	T1637	pobj	activation,of
R1279	T1640	T1639	prep	of,activation
R1280	T1641	T1642	amod	TLR4-mediated,signaling
R1281	T1642	T1640	pobj	signaling,of
R1282	T1643	T1639	prep	in,activation
R1283	T1644	T1646	compound	rat,tissue
R1284	T1645	T1646	compound	brain,tissue
R1285	T1646	T1643	pobj	tissue,in
R1286	T1647	T1630	prep	after,distribution
R1287	T1648	T1647	pobj	ICH,after
R1288	T1649	T1625	punct	.,provided
R1534	T1989	T1989	ROOT	2.1,2.1
R1535	T1990	T1989	punct	.,2.1
R1536	T1991	T2008	nsubjpass	Animals,provided
R1537	T1992	T1994	nummod	Ninety,rats
R1538	T1993	T1994	compound	Wister,rats
R1539	T1994	T2008	nsubjpass	rats,provided
R1540	T1995	T1994	punct	(,rats
R1541	T1996	T1999	amod	male,weight
R1542	T1997	T1999	punct	",",weight
R1543	T1998	T1999	compound	body,weight
R1544	T1999	T1994	appos	weight,rats
R1545	T2000	T1999	punct	:,weight
R1546	T2001	T2002	meta	250,g
R1547	T2002	T1999	appos	g,weight
R1548	T2003	T2002	prep	to,g
R1549	T2004	T2005	nummod	300,g
R1550	T2005	T2003	pobj	g,to
R1551	T2006	T1999	punct	),weight
R1552	T2007	T2008	auxpass	were,provided
R1553	T2008	T2008	ROOT	provided,provided
R1554	T2009	T2008	agent	by,provided
R1555	T2010	T2012	compound	Experimental,Center
R1556	T2011	T2012	compound	Animal,Center
R1557	T2012	T2009	pobj	Center,by
R1558	T2013	T2012	punct	",",Center
R1559	T2014	T2016	compound	China,University
R1560	T2015	T2016	compound	Medical,University
R1561	T2016	T2012	conj	University,Center
R1562	T2017	T2008	punct	.,provided
R1563	T2018	T2019	det	The,rats
R1564	T2019	T2021	nsubjpass	rats,assigned
R1565	T2020	T2021	auxpass	were,assigned
R1566	T2021	T2021	ROOT	assigned,assigned
R1567	T2022	T2021	advmod	randomly,assigned
R1568	T2023	T2021	prep	to,assigned
R1569	T2024	T2025	nummod	three,groups
R1570	T2025	T2023	pobj	groups,to
R1571	T2026	T2025	punct	:,groups
R1572	T2027	T2028	amod	normal,group
R1573	T2028	T2025	appos	group,groups
R1574	T2029	T2030	punct	(,N
R1575	T2030	T2028	appos	N,group
R1576	T2031	T2028	punct	",",group
R1577	T2032	T2052	dep	n,injection
R1578	T2033	T2034	punct	=,10
R1579	T2034	T2032	prep	10,n
R1580	T2035	T2032	punct	",",n
R1581	T2036	T2032	prep	without,n
R1582	T2037	T2038	det	any,treatment
R1583	T2038	T2036	pobj	treatment,without
R1584	T2039	T2032	punct	),n
R1585	T2040	T2032	punct	",",n
R1586	T2041	T2043	amod	normal,control
R1587	T2042	T2043	amod	saline,control
R1588	T2043	T2032	dobj	control,n
R1589	T2044	T2045	punct	(,S
R1590	T2045	T2052	dep	S,injection
R1591	T2046	T2052	punct	",",injection
R1592	T2047	T2052	nmod	n,injection
R1593	T2048	T2049	punct	=,40
R1594	T2049	T2047	prep	40,n
R1595	T2050	T2052	punct	",",injection
R1596	T2051	T2052	amod	intra-cerebral,injection
R1597	T2052	T2064	nmod	injection,ICH
R1598	T2053	T2052	prep	of,injection
R1599	T2054	T2055	amod	normal,saline
R1600	T2055	T2053	pobj	saline,of
R1601	T2056	T2052	prep	as,injection
R1602	T2057	T2056	pobj	control,as
R1603	T2058	T2052	punct	),injection
R1604	T2059	T2052	cc	and,injection
R1605	T2060	T2062	amod	intra-cerebral,group
R1606	T2061	T2062	compound	hemorrhage,group
R1607	T2062	T2052	conj	group,injection
R1608	T2063	T2064	punct	(,ICH
R1609	T2064	T2028	appos	ICH,group
R1610	T2065	T2064	punct	",",ICH
R1611	T2066	T2064	conj	n,ICH
R1612	T2067	T2068	punct	=,40
R1613	T2068	T2066	prep	40,n
R1614	T2069	T2066	punct	),n
R1615	T2070	T2021	punct	.,assigned
R1616	T2071	T2073	det	The,protocol
R1617	T2072	T2073	amod	experimental,protocol
R1618	T2073	T2078	nsubjpass	protocol,approved
R1619	T2074	T2073	acl	used,protocol
R1620	T2075	T2074	prep	for,used
R1621	T2076	T2075	pobj	animals,for
R1622	T2077	T2078	auxpass	was,approved
R1623	T2078	T2078	ROOT	approved,approved
R1624	T2079	T2078	agent	by,approved
R1625	T2080	T2085	det	the,Committee
R1626	T2081	T2082	compound	Animal,Care
R1627	T2082	T2085	nmod	Care,Committee
R1628	T2083	T2082	cc	and,Care
R1629	T2084	T2085	compound	Use,Committee
R1630	T2085	T2079	pobj	Committee,by
R1631	T2086	T2085	punct	",",Committee
R1632	T2087	T2089	compound	China,University
R1633	T2088	T2089	compound	Medical,University
R1634	T2089	T2085	conj	University,Committee
R1635	T2090	T2078	punct	.,approved
R1636	T2091	T2092	det	The,rats
R1637	T2092	T2094	nsubjpass	rats,subjected
R1638	T2093	T2094	auxpass	were,subjected
R1639	T2094	T2094	ROOT	subjected,subjected
R1640	T2095	T2094	prep	to,subjected
R1641	T2096	T2097	amod	intra-cerebral,injection
R1642	T2097	T2095	pobj	injection,to
R1643	T2098	T2097	prep	of,injection
R1644	T2099	T2100	amod	normal,saline
R1645	T2100	T2104	nmod	saline,blood
R1646	T2101	T2100	cc	or,saline
R1647	T2102	T2100	conj	autologous,saline
R1648	T2103	T2104	amod	whole,blood
R1649	T2104	T2098	pobj	blood,of
R1650	T2105	T2094	cc	and,subjected
R1651	T2106	T2107	auxpass	were,sacrificed
R1652	T2107	T2094	conj	sacrificed,subjected
R1653	T2108	T2107	prep	on,sacrificed
R1654	T2109	T2110	nummod	6,hours
R1655	T2110	T2108	pobj	hours,on
R1656	T2111	T2110	punct	",",hours
R1657	T2112	T2113	nummod	1,day
R1658	T2113	T2110	npadvmod	day,hours
R1659	T2114	T2110	punct	",",hours
R1660	T2115	T2116	nummod	3,days
R1661	T2116	T2110	appos	days,hours
R1662	T2117	T2116	cc	and,days
R1663	T2118	T2119	nummod	7,days
R1664	T2119	T2116	conj	days,days
R1665	T2120	T2119	prep	after,days
R1666	T2121	T2122	det	the,injection
R1667	T2122	T2120	pobj	injection,after
R1668	T2123	T2119	punct	",",days
R1669	T2124	T2116	advmod	respectively,days
R1670	T2125	T2094	punct	.,subjected
R1671	T2126	T2127	nummod	Five,rats
R1672	T2127	T2136	nsubjpass	rats,sacrificed
R1673	T2128	T2127	prep	in,rats
R1674	T2129	T2130	det	each,group
R1675	T2130	T2128	pobj	group,in
R1676	T2131	T2127	prep	at,rats
R1677	T2132	T2133	det	each,time
R1678	T2133	T2131	pobj	time,at
R1679	T2134	T2136	nsubjpass	point,sacrificed
R1680	T2135	T2136	auxpass	were,sacrificed
R1681	T2136	T2136	ROOT	sacrificed,sacrificed
R1682	T2137	T2136	agent	by,sacrificed
R1683	T2138	T2139	amod	transcardially,perfusion
R1684	T2139	T2137	pobj	perfusion,by
R1685	T2140	T2139	prep	of,perfusion
R1686	T2141	T2142	amod	normal,saline
R1687	T2142	T2140	pobj	saline,of
R1688	T2143	T2136	advcl	followed,sacrificed
R1689	T2144	T2143	agent	by,followed
R1690	T2145	T2146	nummod	4,%
R1691	T2146	T2144	pobj	%,by
R1692	T2147	T2136	conj	buffered,sacrificed
R1693	T2148	T2149	compound	Para,formaldehyde
R1694	T2149	T2147	dobj	formaldehyde,buffered
R1695	T2150	T2153	punct	(,7.4
R1696	T2151	T2153	quantmod	pH,7.4
R1697	T2152	T2153	punct	=,7.4
R1698	T2153	T2149	appos	7.4,formaldehyde
R1699	T2154	T2149	punct	),formaldehyde
R1700	T2155	T2136	punct	.,sacrificed
R1701	T2156	T2157	det	The,brains
R1702	T2157	T2159	nsubjpass	brains,removed
R1703	T2158	T2159	auxpass	were,removed
R1704	T2159	T2159	ROOT	removed,removed
R1705	T2160	T2159	punct	",",removed
R1706	T2161	T2159	conj	postfixed,removed
R1707	T2162	T2161	punct	",",postfixed
R1708	T2163	T2161	amod	embedded,postfixed
R1709	T2164	T2163	prep	in,embedded
R1710	T2165	T2164	pobj	paraffin,in
R1711	T2166	T2161	punct	",",postfixed
R1712	T2167	T2161	cc	and,postfixed
R1713	T2168	T2161	conj	cut,postfixed
R1714	T2169	T2168	prep	into,cut
R1715	T2170	T2169	pobj	sections,into
R1716	T2171	T2170	punct	(,sections
R1717	T2172	T2173	nummod	7,μm
R1718	T2173	T2170	appos	μm,sections
R1719	T2174	T2170	punct	),sections
R1720	T2175	T2176	mark	as,described
R1721	T2176	T2161	advcl	described,postfixed
R1722	T2177	T2178	advmod	previously,[
R1723	T2178	T2180	amod	[,]
R1724	T2179	T2180	nummod	8,]
R1725	T2180	T2176	dobj	],described
R1726	T2181	T2159	punct	.,removed
R1727	T2182	T2183	nummod	Five,rats
R1728	T2183	T2192	nsubjpass	rats,sacrificed
R1729	T2184	T2183	prep	in,rats
R1730	T2185	T2186	det	each,group
R1731	T2186	T2184	pobj	group,in
R1732	T2187	T2183	prep	at,rats
R1733	T2188	T2189	det	each,time
R1734	T2189	T2190	compound	time,point
R1735	T2190	T2187	pobj	point,at
R1736	T2191	T2192	auxpass	were,sacrificed
R1737	T2192	T2192	ROOT	sacrificed,sacrificed
R1738	T2193	T2192	agent	by,sacrificed
R1739	T2194	T2192	prep	over,sacrificed
R1740	T2195	T2196	compound	dose,injection
R1741	T2196	T2194	pobj	injection,over
R1742	T2197	T2196	prep	of,injection
R1743	T2198	T2197	pobj	Ketamine,of
R1744	T2199	T2192	punct	.,sacrificed
R1745	T2200	T2201	det	The,brains
R1746	T2201	T2203	nsubjpass	brains,removed
R1747	T2202	T2203	auxpass	were,removed
R1748	T2203	T2203	ROOT	removed,removed
R1749	T2204	T2203	cc	and,removed
R1750	T2205	T2203	conj	stored,removed
R1751	T2206	T2205	prep	at,stored
R1752	T2207	T2210	det	minus,C
R1753	T2208	T2209	nummod	80,°
R1754	T2209	T2210	nummod	°,C
R1755	T2210	T2205	npadvmod	C,stored
R1756	T2211	T2210	prep	for,C
R1757	T2212	T2211	pobj	RT-PCR,for
R1758	T2213	T2212	cc	and,RT-PCR
R1759	T2214	T2215	compound	Western,Blots
R1760	T2215	T2212	conj	Blots,RT-PCR
R1761	T2216	T2203	punct	.,removed
R1960	T2449	T2449	ROOT	2.2,2.2
R1961	T2450	T2449	punct	.,2.2
R1962	T2451	T2476	npadvmod	Induction,induced
R1963	T2452	T2451	prep	of,Induction
R1964	T2453	T2454	compound	Intracerebral,Hemorrhage
R1965	T2454	T2452	pobj	Hemorrhage,of
R1966	T2455	T2459	mark	Since,occur
R1967	T2456	T2458	amod	most,hemorrhages
R1968	T2457	T2458	amod	intracerebral,hemorrhages
R1969	T2458	T2459	nsubj	hemorrhages,occur
R1970	T2459	T2476	advcl	occur,induced
R1971	T2460	T2459	prep	in,occur
R1972	T2461	T2463	det	the,ganglia
R1973	T2462	T2463	amod	basal,ganglia
R1974	T2463	T2460	pobj	ganglia,in
R1975	T2464	T2459	advmod	clinically,occur
R1976	T2465	T2476	punct	",",induced
R1977	T2466	T2476	prep	in,induced
R1978	T2467	T2469	det	the,study
R1979	T2468	T2469	amod	present,study
R1980	T2469	T2466	pobj	study,in
R1981	T2470	T2469	punct	",",study
R1982	T2471	T2472	compound	rat,model
R1983	T2472	T2469	appos	model,study
R1984	T2473	T2472	prep	of,model
R1985	T2474	T2473	pobj	ICH,of
R1986	T2475	T2476	auxpass	was,induced
R1987	T2476	T2476	ROOT	induced,induced
R1988	T2477	T2476	prep	in,induced
R1989	T2478	T2480	amod	left,ganglia
R1990	T2479	T2480	amod	basal,ganglia
R1991	T2480	T2477	pobj	ganglia,in
R1992	T2481	T2476	punct	.,induced
R1993	T2482	T2483	nsubj	Rats,were
R1994	T2483	T2483	ROOT	were,were
R1995	T2484	T2483	acomp	anesthetized,were
R1996	T2485	T2484	prep	with,anesthetized
R1997	T2486	T2487	amod	intra-peritoneal,sodium
R1998	T2487	T2485	pobj	sodium,with
R1999	T2488	T2487	amod	pentobarbital,sodium
R2000	T2489	T2491	punct	(,mg/kg
R2001	T2490	T2491	nummod	60,mg/kg
R2002	T2491	T2488	appos	mg/kg,pentobarbital
R2003	T2492	T2491	punct	),mg/kg
R2004	T2493	T2483	punct	.,were
R2005	T2494	T2495	det	The,body
R2006	T2495	T2501	nsubjpass	body,maintained
R2007	T2496	T2495	punct	(,body
R2008	T2497	T2495	appos	rectal,body
R2009	T2498	T2495	punct	),body
R2010	T2499	T2501	nsubjpass	temperature,maintained
R2011	T2500	T2501	auxpass	was,maintained
R2012	T2501	T2501	ROOT	maintained,maintained
R2013	T2502	T2501	prep	at,maintained
R2014	T2503	T2504	nummod	37,°
R2015	T2504	T2505	nummod	°,C
R2016	T2505	T2502	pobj	C,at
R2017	T2506	T2501	prep	during,maintained
R2018	T2507	T2508	det	the,surgery
R2019	T2508	T2506	pobj	surgery,during
R2020	T2509	T2501	advcl	using,maintained
R2021	T2510	T2513	det	a,system
R2022	T2511	T2513	amod	feedback-controlled,system
R2023	T2512	T2513	compound	heating,system
R2024	T2513	T2509	dobj	system,using
R2025	T2514	T2501	punct	.,maintained
R2026	T2515	T2516	det	The,rats
R2027	T2516	T2518	nsubjpass	rats,positioned
R2028	T2517	T2518	auxpass	were,positioned
R2029	T2518	T2518	ROOT	positioned,positioned
R2030	T2519	T2518	prep	in,positioned
R2031	T2520	T2522	det	a,frame
R2032	T2521	T2522	compound	stereotactic,frame
R2033	T2522	T2519	pobj	frame,in
R2034	T2523	T2518	punct	",",positioned
R2035	T2524	T2518	cc	and,positioned
R2036	T2525	T2526	det	the,scalp
R2037	T2526	T2528	nsubjpass	scalp,incised
R2038	T2527	T2528	auxpass	was,incised
R2039	T2528	T2518	conj	incised,positioned
R2040	T2529	T2528	prep	along,incised
R2041	T2530	T2531	det	the,midline
R2042	T2531	T2529	pobj	midline,along
R2043	T2532	T2528	punct	.,incised
R2044	T2533	T2544	advcl	Using,opened
R2045	T2534	T2536	det	a,technique
R2046	T2535	T2536	amod	sterile,technique
R2047	T2536	T2533	dobj	technique,Using
R2048	T2537	T2544	punct	",",opened
R2049	T2538	T2542	det	a,hole
R2050	T2539	T2540	nummod	1,mm
R2051	T2540	T2542	compound	mm,hole
R2052	T2541	T2542	compound	burr,hole
R2053	T2542	T2544	nsubjpass	hole,opened
R2054	T2543	T2544	auxpass	was,opened
R2055	T2544	T2544	ROOT	opened,opened
R2056	T2545	T2544	prep	in,opened
R2057	T2546	T2547	det	the,skull
R2058	T2547	T2545	pobj	skull,in
R2059	T2548	T2544	prep	on,opened
R2060	T2549	T2552	det	the,suture
R2061	T2550	T2552	amod	left,suture
R2062	T2551	T2552	amod	coronal,suture
R2063	T2552	T2548	pobj	suture,on
R2064	T2553	T2554	nummod	3,mm
R2065	T2554	T2544	npadvmod	mm,opened
R2066	T2555	T2554	amod	lateral,mm
R2067	T2556	T2544	prep	to,opened
R2068	T2557	T2558	det	the,midline
R2069	T2558	T2556	pobj	midline,to
R2070	T2559	T2544	punct	.,opened
R2071	T2560	T2563	det	A,needle
R2072	T2561	T2563	amod	blunt,needle
R2073	T2562	T2563	amod	26-gauge,needle
R2074	T2563	T2565	nsubjpass	needle,inserted
R2075	T2564	T2565	auxpass	was,inserted
R2076	T2565	T2565	ROOT	inserted,inserted
R2077	T2566	T2565	prep	into,inserted
R2078	T2567	T2570	det	the,ganglia
R2079	T2568	T2570	amod	left,ganglia
R2080	T2569	T2570	amod	basal,ganglia
R2081	T2570	T2566	pobj	ganglia,into
R2082	T2571	T2570	prep	under,ganglia
R2083	T2572	T2573	amod	stereotactic,guidance
R2084	T2573	T2571	pobj	guidance,under
R2085	T2574	T2575	punct	(,coordinates
R2086	T2575	T2565	parataxis	coordinates,inserted
R2087	T2576	T2575	punct	:,coordinates
R2088	T2577	T2578	nummod	0.2,mm
R2089	T2578	T2579	compound	mm,anterior
R2090	T2579	T2575	dobj	anterior,coordinates
R2091	T2580	T2579	punct	",",anterior
R2092	T2581	T2582	nummod	6.0,mm
R2093	T2582	T2583	compound	mm,ventral
R2094	T2583	T2579	conj	ventral,anterior
R2095	T2584	T2583	punct	",",ventral
R2096	T2585	T2583	cc	and,ventral
R2097	T2586	T2587	nummod	3.0,mm
R2098	T2587	T2583	conj	mm,ventral
R2099	T2588	T2587	amod	lateral,mm
R2100	T2589	T2575	prep	to,coordinates
R2101	T2590	T2591	det	the,midline
R2102	T2591	T2589	pobj	midline,to
R2103	T2592	T2575	punct	),coordinates
R2104	T2593	T2565	punct	.,inserted
R2105	T2594	T2604	advmod	Then,infused
R2106	T2595	T2604	punct	",",infused
R2107	T2596	T2598	det	a,μL
R2108	T2597	T2598	nummod	75,μL
R2109	T2598	T2604	nsubjpass	μL,infused
R2110	T2599	T2598	prep	of,μL
R2111	T2600	T2602	amod	autologous,blood
R2112	T2601	T2602	amod	whole,blood
R2113	T2602	T2599	pobj	blood,of
R2114	T2603	T2604	auxpass	was,infused
R2115	T2604	T2604	ROOT	infused,infused
R2116	T2605	T2604	prep	at,infused
R2117	T2606	T2607	det	a,rate
R2118	T2607	T2605	pobj	rate,at
R2119	T2608	T2607	prep	of,rate
R2120	T2609	T2612	nummod	20,min
R2121	T2610	T2612	compound	μL,min
R2122	T2611	T2612	compound	/,min
R2123	T2612	T2608	pobj	min,of
R2124	T2613	T2604	prep	with,infused
R2125	T2614	T2615	det	the,use
R2126	T2615	T2613	pobj	use,with
R2127	T2616	T2615	prep	of,use
R2128	T2617	T2619	det	a,pump
R2129	T2618	T2619	amod	microinfusion,pump
R2130	T2619	T2616	pobj	pump,of
R2131	T2620	T2604	punct	.,infused
R2132	T2621	T2631	prep	After,withdrawn
R2133	T2622	T2623	det	the,completion
R2134	T2623	T2621	pobj	completion,After
R2135	T2624	T2623	prep	of,completion
R2136	T2625	T2626	det	the,infusion
R2137	T2626	T2624	pobj	infusion,of
R2138	T2627	T2631	punct	",",withdrawn
R2139	T2628	T2629	det	the,needle
R2140	T2629	T2631	nsubjpass	needle,withdrawn
R2141	T2630	T2631	auxpass	was,withdrawn
R2142	T2631	T2631	ROOT	withdrawn,withdrawn
R2143	T2632	T2631	advmod	quickly,withdrawn
R2144	T2633	T2631	punct	",",withdrawn
R2145	T2634	T2635	compound	cyanoacrylate,glue
R2146	T2635	T2637	nsubjpass	glue,placed
R2147	T2636	T2637	auxpass	was,placed
R2148	T2637	T2631	conj	placed,withdrawn
R2149	T2638	T2637	prep	around,placed
R2150	T2639	T2641	det	the,hole
R2151	T2640	T2641	compound	burr,hole
R2152	T2641	T2638	pobj	hole,around
R2153	T2642	T2637	punct	",",placed
R2154	T2643	T2637	cc	and,placed
R2155	T2644	T2646	det	the,incision
R2156	T2645	T2646	compound	skin,incision
R2157	T2646	T2647	nsubj	incision,was
R2158	T2647	T2637	conj	was,placed
R2159	T2648	T2647	acomp	closed,was
R2160	T2649	T2648	prep	with,closed
R2161	T2650	T2649	pobj	sutures,with
R2162	T2651	T2647	punct	.,was
R2163	T2652	T2665	prep	For,injected
R2164	T2653	T2657	det	the,rats
R2165	T2654	T2657	amod	normal,rats
R2166	T2655	T2656	amod	saline,control
R2167	T2656	T2657	compound	control,rats
R2168	T2657	T2652	pobj	rats,For
R2169	T2658	T2665	punct	",",injected
R2170	T2659	T2660	advmod	only,75
R2171	T2660	T2663	nummod	75,saline
R2172	T2661	T2663	nmod	μL,saline
R2173	T2662	T2663	amod	normal,saline
R2174	T2663	T2665	nsubjpass	saline,injected
R2175	T2664	T2665	auxpass	was,injected
R2176	T2665	T2665	ROOT	injected,injected
R2177	T2666	T2665	punct	.,injected
R2436	T3069	T3069	ROOT	2.3,2.3
R2437	T3070	T3069	punct	.,2.3
R2438	T3071	T3086	advcl	Detection,isolated
R2439	T3072	T3071	prep	of,Detection
R2440	T3073	T3074	compound	TLR4,mRNA
R2441	T3074	T3072	pobj	mRNA,of
R2442	T3075	T3071	prep	by,Detection
R2443	T3076	T3077	det	the,Method
R2444	T3077	T3075	pobj	Method,by
R2445	T3078	T3077	prep	of,Method
R2446	T3079	T3080	compound	RT-PCR,Briefly
R2447	T3080	T3078	pobj	Briefly,of
R2448	T3081	T3086	punct	",",isolated
R2449	T3082	T3084	amod	total,samples
R2450	T3083	T3084	compound	RNA,samples
R2451	T3084	T3086	nsubjpass	samples,isolated
R2452	T3085	T3086	auxpass	were,isolated
R2453	T3086	T3086	ROOT	isolated,isolated
R2454	T3087	T3086	prep	from,isolated
R2455	T3088	T3089	amod	peri-hemorrhage,regions
R2456	T3089	T3087	pobj	regions,from
R2457	T3090	T3087	prep	in,from
R2458	T3091	T3093	amod	left,ganglia
R2459	T3092	T3093	amod	basal,ganglia
R2460	T3093	T3090	pobj	ganglia,in
R2461	T3094	T3086	advcl	using,isolated
R2462	T3095	T3100	advmod	Simply,Kit
R2463	T3096	T3100	nmod	P,Kit
R2464	T3097	T3100	compound	Total,Kit
R2465	T3098	T3099	compound	RNA,isolation
R2466	T3099	T3100	compound	isolation,Kit
R2467	T3100	T3094	dobj	Kit,using
R2468	T3101	T3102	punct	(,BioFlux
R2469	T3102	T3100	appos	BioFlux,Kit
R2470	T3103	T3102	punct	",",BioFlux
R2471	T3104	T3102	conj	HZ,BioFlux
R2472	T3105	T3104	punct	",",HZ
R2473	T3106	T3104	npadvmod	China,HZ
R2474	T3107	T3104	punct	),HZ
R2475	T3108	T3086	prep	according,isolated
R2476	T3109	T3108	prep	to,according
R2477	T3110	T3111	det	the,manufacturer
R2478	T3111	T3113	poss	manufacturer,instructions
R2479	T3112	T3111	case	's,manufacturer
R2480	T3113	T3109	pobj	instructions,to
R2481	T3114	T3086	punct	.,isolated
R2482	T3115	T3116	det	The,quantity
R2483	T3116	T3121	nsubjpass	quantity,determined
R2484	T3117	T3116	prep	of,quantity
R2485	T3118	T3119	amod	total,RNA
R2486	T3119	T3117	pobj	RNA,of
R2487	T3120	T3121	auxpass	was,determined
R2488	T3121	T3121	ROOT	determined,determined
R2489	T3122	T3121	prep	on,determined
R2490	T3123	T3124	det	a,Nanodrop
R2491	T3124	T3122	pobj	Nanodrop,on
R2492	T3125	T3124	punct	(,Nanodrop
R2493	T3126	T3127	compound	ND-1000,Spectrophotometer
R2494	T3127	T3124	appos	Spectrophotometer,Nanodrop
R2495	T3128	T3124	punct	),Nanodrop
R2496	T3129	T3121	prep	by,determined
R2497	T3130	T3129	pcomp	measuring,by
R2498	T3131	T3132	amod	optical,density
R2499	T3132	T3130	dobj	density,measuring
R2500	T3133	T3130	prep	at,measuring
R2501	T3134	T3133	pobj	A260,at
R2502	T3135	T3134	cc	and,A260
R2503	T3136	T3134	conj	A280,A260
R2504	T3137	T3138	compound	nm,wavelength
R2505	T3138	T3130	npadvmod	wavelength,measuring
R2506	T3139	T3121	punct	.,determined
R2507	T3140	T3147	advmod	Then,adjusted
R2508	T3141	T3147	punct	",",adjusted
R2509	T3142	T3143	det	the,concentrations
R2510	T3143	T3147	nsubjpass	concentrations,adjusted
R2511	T3144	T3143	prep	of,concentrations
R2512	T3145	T3144	pobj	mRNA,of
R2513	T3146	T3147	auxpass	were,adjusted
R2514	T3147	T3147	ROOT	adjusted,adjusted
R2515	T3148	T3147	prep	to,adjusted
R2516	T3149	T3150	nummod	1.0,g/mL
R2517	T3150	T3148	pobj	g/mL,to
R2518	T3151	T3147	punct	.,adjusted
R2519	T3152	T3154	nsubjpass	RNA,reverse-transcribed
R2520	T3153	T3154	auxpass	was,reverse-transcribed
R2521	T3154	T3154	ROOT	reverse-transcribed,reverse-transcribed
R2522	T3155	T3154	prep	into,reverse-transcribed
R2523	T3156	T3155	pobj	cDNA,into
R2524	T3157	T3154	prep	in,reverse-transcribed
R2525	T3158	T3161	nummod	20,system
R2526	T3159	T3161	compound	μL,system
R2527	T3160	T3161	compound	reaction,system
R2528	T3161	T3157	pobj	system,in
R2529	T3162	T3154	advcl	using,reverse-transcribed
R2530	T3163	T3166	compound	Superscript,Kit
R2531	T3164	T3166	compound	First-Strand,Kit
R2532	T3165	T3166	compound	Synthesis,Kit
R2533	T3166	T3162	dobj	Kit,using
R2534	T3167	T3162	prep	for,using
R2535	T3168	T3167	pobj	RT-PCR,for
R2536	T3169	T3171	punct	(,Inc
R2537	T3170	T3171	compound	promega,Inc
R2538	T3171	T3168	appos	Inc,RT-PCR
R2539	T3172	T3168	punct	),RT-PCR
R2540	T3173	T3162	prep	under,using
R2541	T3174	T3173	pobj	conditions,under
R2542	T3175	T3174	acl	described,conditions
R2543	T3176	T3175	agent	by,described
R2544	T3177	T3178	det	the,supplier
R2545	T3178	T3176	pobj	supplier,by
R2546	T3179	T3154	punct	.,reverse-transcribed
R2547	T3180	T3181	nummod	One,microliter
R2548	T3181	T3185	nsubjpass	microliter,used
R2549	T3182	T3181	prep	of,microliter
R2550	T3183	T3182	pobj	cDNA,of
R2551	T3184	T3185	auxpass	was,used
R2552	T3185	T3185	ROOT	used,used
R2553	T3186	T3187	aux	to,amplify
R2554	T3187	T3185	xcomp	amplify,used
R2555	T3188	T3191	det	the,fragment
R2556	T3189	T3191	nummod	TLR4,fragment
R2557	T3190	T3191	compound	gene,fragment
R2558	T3191	T3187	dobj	fragment,amplify
R2559	T3192	T3187	prep	with,amplify
R2560	T3193	T3196	nummod	1,buffer
R2561	T3194	T3196	nummod	×,buffer
R2562	T3195	T3196	compound	PCR,buffer
R2563	T3196	T3192	pobj	buffer,with
R2564	T3197	T3196	punct	",",buffer
R2565	T3198	T3200	nummod	1.5,MgCl2
R2566	T3199	T3200	compound	mM,MgCl2
R2567	T3200	T3196	appos	MgCl2,buffer
R2568	T3201	T3200	punct	",",MgCl2
R2569	T3202	T3203	nummod	200,μM
R2570	T3203	T3200	appos	μM,MgCl2
R2571	T3204	T3203	prep	of,μM
R2572	T3205	T3206	det	each,dNTP
R2573	T3206	T3204	pobj	dNTP,of
R2574	T3207	T3203	punct	",",μM
R2575	T3208	T3209	nummod	200,μM
R2576	T3209	T3203	conj	μM,μM
R2577	T3210	T3209	prep	of,μM
R2578	T3211	T3210	pobj	primers,of
R2579	T3212	T3209	punct	",",μM
R2580	T3213	T3209	cc	and,μM
R2581	T3214	T3217	nummod	2u,polymerase
R2582	T3215	T3217	compound	Taq,polymerase
R2583	T3216	T3217	compound	DNA,polymerase
R2584	T3217	T3209	conj	polymerase,μM
R2585	T3218	T3185	punct	.,used
R2586	T3219	T3220	det	The,house
R2587	T3220	T3222	compound	house,gene
R2588	T3221	T3222	compound	keep,gene
R2589	T3222	T3227	nsubjpass	gene,used
R2590	T3223	T3222	punct	(,gene
R2591	T3224	T3222	appos	β-actin,gene
R2592	T3225	T3222	punct	),gene
R2593	T3226	T3227	auxpass	was,used
R2594	T3227	T3227	ROOT	used,used
R2595	T3228	T3227	prep	as,used
R2596	T3229	T3231	det	an,control
R2597	T3230	T3231	amod	internal,control
R2598	T3231	T3228	pobj	control,as
R2599	T3232	T3227	punct	.,used
R2600	T3233	T3236	det	The,sequences
R2601	T3234	T3235	compound	PCR,primer
R2602	T3235	T3236	compound	primer,sequences
R2603	T3236	T3238	nsubjpass	sequences,designed
R2604	T3237	T3238	auxpass	were,designed
R2605	T3238	T3238	ROOT	designed,designed
R2606	T3239	T3238	prep	according,designed
R2607	T3240	T3239	prep	to,according
R2608	T3241	T3246	det	the,sequences
R2609	T3242	T3246	nummod	TLR4,sequences
R2610	T3243	T3242	cc	and,TLR4
R2611	T3244	T3242	conj	β-actin,TLR4
R2612	T3245	T3246	compound	gene,sequences
R2613	T3246	T3240	pobj	sequences,to
R2614	T3247	T3246	acl	reported,sequences
R2615	T3248	T3247	prep	in,reported
R2616	T3249	T3248	pobj	GenBank,in
R2617	T3250	T3238	punct	.,designed
R2618	T3251	T3251	ROOT	TLR4,TLR4
R2619	T3252	T3254	punct	(,bp
R2620	T3253	T3254	nummod	145,bp
R2621	T3254	T3251	appos	bp,TLR4
R2622	T3255	T3254	punct	),bp
R2623	T3256	T3254	punct	:,bp
R2624	T3257	T3263	advmod	forward,′
R2625	T3258	T3259	punct	:,5
R2626	T3259	T3263	nummod	5,′
R2627	T3260	T3259	punct	′,5
R2628	T3261	T3262	punct	-,AGCTTTGGTCAGTTGGCTCT-3
R2629	T3262	T3263	compound	AGCTTTGGTCAGTTGGCTCT-3,′
R2630	T3263	T3254	appos	′,bp
R2631	T3264	T3254	punct	;,bp
R2632	T3265	T3287	ccomp	reverse,reverse
R2633	T3266	T3265	punct	:,reverse
R2634	T3267	T3271	nummod	5,′
R2635	T3268	T3270	punct	′,CAGGATGACACCATTGAAGC-3
R2636	T3269	T3270	punct	-,CAGGATGACACCATTGAAGC-3
R2637	T3270	T3271	compound	CAGGATGACACCATTGAAGC-3,′
R2638	T3271	T3265	appos	′,reverse
R2639	T3272	T3287	punct	;,reverse
R2640	T3273	T3287	ccomp	β-actin,reverse
R2641	T3274	T3276	punct	(,bp
R2642	T3275	T3276	nummod	701,bp
R2643	T3276	T3273	appos	bp,β-actin
R2644	T3277	T3273	punct	),β-actin
R2645	T3278	T3273	punct	:,β-actin
R2646	T3279	T3273	advmod	forward,β-actin
R2647	T3280	T3273	punct	:,β-actin
R2648	T3281	T3284	meta	5,GCCAACCGTGAAAAAGATG-3
R2649	T3282	T3281	punct	′,5
R2650	T3283	T3284	punct	-,GCCAACCGTGAAAAAGATG-3
R2651	T3284	T3285	compound	GCCAACCGTGAAAAAGATG-3,′
R2652	T3285	T3273	appos	′,β-actin
R2653	T3286	T3287	punct	;,reverse
R2654	T3287	T3251	appos	reverse,TLR4
R2655	T3288	T3287	punct	:,reverse
R2656	T3289	T3292	nummod	5,CCAGGATAGAGCCACCAAT-3
R2657	T3290	T3292	punct	′,CCAGGATAGAGCCACCAAT-3
R2658	T3291	T3292	punct	-,CCAGGATAGAGCCACCAAT-3
R2659	T3292	T3293	compound	CCAGGATAGAGCCACCAAT-3,′
R2660	T3293	T3287	appos	′,reverse
R2661	T3294	T3287	punct	.,reverse
R2662	T3295	T3296	compound	Reaction,cycles
R2663	T3296	T3298	nsubjpass	cycles,performed
R2664	T3297	T3298	auxpass	were,performed
R2665	T3298	T3298	ROOT	performed,performed
R2666	T3299	T3298	prep	at,performed
R2667	T3300	T3302	det	the,condition
R2668	T3301	T3302	amod	following,condition
R2669	T3302	T3299	pobj	condition,at
R2670	T3303	T3298	punct	:,performed
R2671	T3304	T3314	nummod	94,s
R2672	T3305	T3306	compound	°,C
R2673	T3306	T3312	nmod	C,C
R2674	T3307	T3306	nummod	2,C
R2675	T3308	T3312	nmod	min,C
R2676	T3309	T3308	punct	",",min
R2677	T3310	T3311	nummod	94,°
R2678	T3311	T3312	compound	°,C
R2679	T3312	T3314	nmod	C,s
R2680	T3313	T3312	nummod	40,C
R2681	T3314	T3298	dep	s,performed
R2682	T3315	T3314	punct	",",s
R2683	T3316	T3327	nummod	55,s
R2684	T3317	T3318	compound	°,C
R2685	T3318	T3327	nmod	C,s
R2686	T3319	T3318	nummod	40,C
R2687	T3320	T3318	prep	s,C
R2688	T3321	T3318	punct	",",C
R2689	T3322	T3318	cc	and,C
R2690	T3323	T3318	conj	72,C
R2691	T3324	T3325	compound	°,C
R2692	T3325	T3327	nmod	C,s
R2693	T3326	T3325	nummod	60,C
R2694	T3327	T3314	appos	s,s
R2695	T3328	T3298	punct	.,performed
R2696	T3329	T3330	det	The,reaction
R2697	T3330	T3332	nsubjpass	reaction,stopped
R2698	T3331	T3332	auxpass	was,stopped
R2699	T3332	T3332	ROOT	stopped,stopped
R2700	T3333	T3332	prep	after,stopped
R2701	T3334	T3335	nummod	31,cycles
R2702	T3335	T3333	pobj	cycles,after
R2703	T3336	T3332	punct	.,stopped
R2704	T3337	T3338	compound	PCR,products
R2705	T3338	T3340	nsubjpass	products,electrophoresed
R2706	T3339	T3340	auxpass	were,electrophoresed
R2707	T3340	T3340	ROOT	electrophoresed,electrophoresed
R2708	T3341	T3340	prep	through,electrophoresed
R2709	T3342	T3343	amod	agarose,gel
R2710	T3343	T3341	pobj	gel,through
R2711	T3344	T3340	punct	.,electrophoresed
R2712	T3345	T3346	compound	Image,Acquisition
R2713	T3346	T3351	nsubjpass	Acquisition,used
R2714	T3347	T3346	cc	and,Acquisition
R2715	T3348	T3346	conj	Analysis,Acquisition
R2716	T3349	T3346	conj	software,Acquisition
R2717	T3350	T3351	auxpass	were,used
R2718	T3351	T3351	ROOT	used,used
R2719	T3352	T3353	aux	to,determine
R2720	T3353	T3351	xcomp	determine,used
R2721	T3354	T3355	compound	band,densities
R2722	T3355	T3353	dobj	densities,determine
R2723	T3356	T3351	punct	.,used
R2724	T3357	T3358	det	The,abundance
R2725	T3358	T3363	nsubjpass	abundance,expressed
R2726	T3359	T3358	prep	of,abundance
R2727	T3360	T3361	nummod	TLR4,mRNA
R2728	T3361	T3359	pobj	mRNA,of
R2729	T3362	T3363	auxpass	was,expressed
R2730	T3363	T3363	ROOT	expressed,expressed
R2731	T3364	T3363	prep	as,expressed
R2732	T3365	T3366	det	the,ratio
R2733	T3366	T3364	pobj	ratio,as
R2734	T3367	T3366	prep	of,ratio
R2735	T3368	T3369	nummod	TLR4,mRNA
R2736	T3369	T3367	pobj	mRNA,of
R2737	T3370	T3371	aux	to,β-actin
R2738	T3371	T3366	relcl	β-actin,ratio
R2739	T3372	T3371	dobj	mRNA,β-actin
R2740	T3373	T3363	punct	.,expressed
R2815	T3606	T3606	ROOT	2.4,2.4
R2816	T3607	T3606	punct	.,2.4
R2817	T3608	T3608	ROOT	Immunohistochemistry,Immunohistochemistry
R2818	T3609	T3610	punct	(,IHC
R2819	T3610	T3608	appos	IHC,Immunohistochemistry
R2820	T3611	T3608	punct	),Immunohistochemistry
R2821	T3612	T3613	det	The,IHC
R2822	T3613	T3618	nsubjpass	IHC,performed
R2823	T3614	T3613	acl	staining,IHC
R2824	T3615	T3614	prep	for,staining
R2825	T3616	T3615	pobj	TLR4,for
R2826	T3617	T3618	auxpass	was,performed
R2827	T3618	T3618	ROOT	performed,performed
R2828	T3619	T3620	mark	as,described
R2829	T3620	T3618	advcl	described,performed
R2830	T3621	T3622	advmod	previously,[
R2831	T3622	T3624	amod	[,]
R2832	T3623	T3624	nummod	8,]
R2833	T3624	T3620	dobj	],described
R2834	T3625	T3618	punct	.,performed
R2835	T3626	T3628	det	The,antibody
R2836	T3627	T3628	amod	primary,antibody
R2837	T3628	T3630	nsubj	antibody,was
R2838	T3629	T3628	acl	employed,antibody
R2839	T3630	T3630	ROOT	was,was
R2840	T3631	T3632	compound	rabbit,anti-TLR4
R2841	T3632	T3630	attr	anti-TLR4,was
R2842	T3633	T3636	punct	(,BA1717
R2843	T3634	T3636	amod	WuHan,BA1717
R2844	T3635	T3636	punct	",",BA1717
R2845	T3636	T3632	appos	BA1717,anti-TLR4
R2846	T3637	T3636	punct	),BA1717
R2847	T3638	T3630	punct	.,was
R2848	T3639	T3642	det	The,antibody
R2849	T3640	T3642	amod	biotinylated,antibody
R2850	T3641	T3642	amod	secondary,antibody
R2851	T3642	T3653	nsubjpass	antibody,obtained
R2852	T3643	T3642	cc	and,antibody
R2853	T3644	T3645	amod	antibody-biotin-avidin-peroxidase,complexes
R2854	T3645	T3642	conj	complexes,antibody
R2855	T3646	T3648	punct	(,reagent
R2856	T3647	T3648	compound	ABC,reagent
R2857	T3648	T3645	appos	reagent,complexes
R2858	T3649	T3648	punct	",",reagent
R2859	T3650	T3648	appos	SC-2018,reagent
R2860	T3651	T3648	punct	),reagent
R2861	T3652	T3653	auxpass	were,obtained
R2862	T3653	T3653	ROOT	obtained,obtained
R2863	T3654	T3653	prep	from,obtained
R2864	T3655	T3658	compound	Santa,Inc.
R2865	T3656	T3658	compound	Cruz,Inc.
R2866	T3657	T3658	compound	Biotechnology,Inc.
R2867	T3658	T3654	pobj	Inc.,from
R2868	T3659	T3658	punct	(,Inc.
R2869	T3660	T3661	compound	Santa,Cruz
R2870	T3661	T3658	npadvmod	Cruz,Inc.
R2871	T3662	T3661	punct	",",Cruz
R2872	T3663	T3661	appos	CA,Cruz
R2873	T3664	T3658	punct	),Inc.
R2874	T3665	T3653	punct	.,obtained
R2875	T3666	T3667	nsubj	Slides,processed
R2876	T3667	T3671	csubj	processed,served
R2877	T3668	T3667	prep	without,processed
R2878	T3669	T3670	amod	primary,antibodies
R2879	T3670	T3668	pobj	antibodies,without
R2880	T3671	T3671	ROOT	served,served
R2881	T3672	T3671	prep	as,served
R2882	T3673	T3674	amod	negative,controls
R2883	T3674	T3672	pobj	controls,as
R2884	T3675	T3671	punct	.,served
R2994	T3848	T3848	ROOT	2.5,2.5
R2995	T3849	T3848	punct	.,2.5
R2996	T3850	T3853	amod	Western,proteins
R2997	T3851	T3853	compound	Blots,proteins
R2998	T3852	T3853	compound	Cellular,proteins
R2999	T3853	T3855	nsubjpass	proteins,prepared
R3000	T3854	T3855	auxpass	were,prepared
R3001	T3855	T3855	ROOT	prepared,prepared
R3002	T3856	T3855	prep	from,prepared
R3003	T3857	T3859	amod	ICH,hemispheres
R3004	T3858	T3859	amod	cerebral,hemispheres
R3005	T3859	T3856	pobj	hemispheres,from
R3006	T3860	T3859	punct	",",hemispheres
R3007	T3861	T3859	acl	electrophoresed,hemispheres
R3008	T3862	T3861	prep	with,electrophoresed
R3009	T3863	T3864	amod	SDS-polyacrylamide,gel
R3010	T3864	T3862	pobj	gel,with
R3011	T3865	T3861	cc	and,electrophoresed
R3012	T3866	T3861	conj	transferred,electrophoresed
R3013	T3867	T3866	prep	onto,transferred
R3014	T3868	T3869	compound	Hybond,ECL
R3015	T3869	T3870	compound	ECL,membranes
R3016	T3870	T3867	pobj	membranes,onto
R3017	T3871	T3873	punct	(,Pharmacia
R3018	T3872	T3873	compound	Amersham,Pharmacia
R3019	T3873	T3870	appos	Pharmacia,membranes
R3020	T3874	T3873	punct	",",Pharmacia
R3021	T3875	T3873	conj	Piscataway,Pharmacia
R3022	T3876	T3875	punct	",",Piscataway
R3023	T3877	T3875	conj	NJ,Piscataway
R3024	T3878	T3870	punct	),membranes
R3025	T3879	T3855	punct	.,prepared
R3026	T3880	T3882	det	The,membranes
R3027	T3881	T3882	compound	ECL,membranes
R3028	T3882	T3884	nsubjpass	membranes,incubated
R3029	T3883	T3884	auxpass	were,incubated
R3030	T3884	T3884	ROOT	incubated,incubated
R3031	T3885	T3884	prep	with,incubated
R3032	T3886	T3889	det	the,antibody
R3033	T3887	T3889	amod	appropriate,antibody
R3034	T3888	T3889	amod	primary,antibody
R3035	T3889	T3885	pobj	antibody,with
R3036	T3890	T3889	punct	(,antibody
R3037	T3891	T3889	appos	WuHan,antibody
R3038	T3892	T3889	punct	",",antibody
R3039	T3893	T3889	appos	BA1717,antibody
R3040	T3894	T3884	punct	),incubated
R3041	T3895	T3884	advcl	followed,incubated
R3042	T3896	T3895	agent	by,followed
R3043	T3897	T3896	pobj	incubation,by
R3044	T3898	T3895	prep	with,followed
R3045	T3899	T3901	amod	peroxidase-conjugated,antibodies
R3046	T3900	T3901	amod	secondary,antibodies
R3047	T3901	T3898	pobj	antibodies,with
R3048	T3902	T3901	punct	(,antibodies
R3049	T3903	T3904	compound	Golden,Bridge
R3050	T3904	T3901	appos	Bridge,antibodies
R3051	T3905	T3904	punct	",",Bridge
R3052	T3906	T3904	appos	PV-6001,Bridge
R3053	T3907	T3904	punct	),Bridge
R3054	T3908	T3884	punct	.,incubated
R3055	T3909	T3910	det	The,signals
R3056	T3910	T3912	nsubjpass	signals,detected
R3057	T3911	T3912	auxpass	were,detected
R3058	T3912	T3912	ROOT	detected,detected
R3059	T3913	T3912	prep	with,detected
R3060	T3914	T3916	det	the,system
R3061	T3915	T3916	compound	ECL,system
R3062	T3916	T3913	pobj	system,with
R3063	T3917	T3916	punct	(,system
R3064	T3918	T3919	compound	Amersham,Pharmacia
R3065	T3919	T3916	appos	Pharmacia,system
R3066	T3920	T3916	punct	),system
R3067	T3921	T3912	punct	.,detected
R3068	T3922	T3924	det	The,membranes
R3069	T3923	T3924	amod	same,membranes
R3070	T3924	T3926	nsubjpass	membranes,probed
R3071	T3925	T3926	auxpass	were,probed
R3072	T3926	T3926	ROOT	probed,probed
R3073	T3927	T3926	prep	with,probed
R3074	T3928	T3927	pobj	anti-GAPDH,with
R3075	T3929	T3928	punct	(,anti-GAPDH
R3076	T3930	T3931	amod	glyceraldehyde-3-phosphate,dehydrogenase
R3077	T3931	T3928	appos	dehydrogenase,anti-GAPDH
R3078	T3932	T3931	punct	",",dehydrogenase
R3079	T3933	T3931	conj	Biodesign,dehydrogenase
R3080	T3934	T3933	punct	",",Biodesign
R3081	T3935	T3933	appos	Saco,Biodesign
R3082	T3936	T3935	punct	",",Saco
R3083	T3937	T3935	npadvmod	Maine,Saco
R3084	T3938	T3935	punct	),Saco
R3085	T3939	T3926	prep	after,probed
R3086	T3940	T3941	auxpass	being,washed
R3087	T3941	T3939	pcomp	washed,after
R3088	T3942	T3941	prep	with,washed
R3089	T3943	T3942	pcomp	stripping,with
R3090	T3944	T3943	dobj	buffer,stripping
R3091	T3945	T3926	punct	.,probed
R3092	T3946	T3947	det	The,signals
R3093	T3947	T3949	nsubjpass	signals,quantified
R3094	T3948	T3949	auxpass	were,quantified
R3095	T3949	T3949	ROOT	quantified,quantified
R3096	T3950	T3949	prep	by,quantified
R3097	T3951	T3950	pcomp	scanning,by
R3098	T3952	T3951	dobj	densitometry,scanning
R3099	T3953	T3952	cc	and,densitometry
R3100	T3954	T3956	amod	computer-assisted,analysis
R3101	T3955	T3956	compound	image,analysis
R3102	T3956	T3952	conj	analysis,densitometry
R3103	T3957	T3949	punct	.,quantified
R3255	T4181	T4181	ROOT	2.6,2.6
R3256	T4182	T4181	punct	.,2.6
R3257	T4183	T4186	compound	Electrophoretic,Assay
R3258	T4184	T4185	compound	Mobility,Shift
R3259	T4185	T4186	compound	Shift,Assay
R3260	T4186	T4193	nsubjpass	Assay,isolated
R3261	T4187	T4188	punct	(,EMSA
R3262	T4188	T4186	appos	EMSA,Assay
R3263	T4189	T4188	punct	),EMSA
R3264	T4190	T4191	compound	Nuclear,proteins
R3265	T4191	T4192	nsubj	proteins,were
R3266	T4192	T4193	auxpass	were,isolated
R3267	T4193	T4193	ROOT	isolated,isolated
R3268	T4194	T4193	prep	from,isolated
R3269	T4195	T4196	compound	brain,tissue
R3270	T4196	T4194	pobj	tissue,from
R3271	T4197	T4193	punct	.,isolated
R3272	T4198	T4206	advmod	Briefly,extract
R3273	T4199	T4206	punct	",",extract
R3274	T4200	T4206	prep	after,extract
R3275	T4201	T4200	pobj	removal,after
R3276	T4202	T4201	prep	of,removal
R3277	T4203	T4202	pobj	supernatant,of
R3278	T4204	T4206	punct	(,extract
R3279	T4205	T4206	nsubj	cytoplasmic,extract
R3280	T4206	T4206	ROOT	extract,extract
R3281	T4207	T4206	punct	),extract
R3282	T4208	T4212	punct	",",resuspended
R3283	T4209	T4210	det	the,pellets
R3284	T4210	T4212	nsubjpass	pellets,resuspended
R3285	T4211	T4212	auxpass	were,resuspended
R3286	T4212	T4212	ROOT	resuspended,resuspended
R3287	T4213	T4212	prep	in,resuspended
R3288	T4214	T4215	amod	nuclear,extraction
R3289	T4215	T4213	pobj	extraction,in
R3290	T4216	T4212	conj	reagent,resuspended
R3291	T4217	T4212	punct	.,resuspended
R3292	T4218	T4219	det	The,tubes
R3293	T4219	T4223	nsubjpass	tubes,put
R3294	T4220	T4219	acl	containing,tubes
R3295	T4221	T4220	dobj	pellets,containing
R3296	T4222	T4223	auxpass	were,put
R3297	T4223	T4223	ROOT	put,put
R3298	T4224	T4223	prep	on,put
R3299	T4225	T4224	pobj	vortex,on
R3300	T4226	T4223	prep	for,put
R3301	T4227	T4228	nummod	15,seconds
R3302	T4228	T4226	pobj	seconds,for
R3303	T4229	T4231	det	every,minutes
R3304	T4230	T4231	nummod	10,minutes
R3305	T4231	T4223	npadvmod	minutes,put
R3306	T4232	T4231	punct	",",minutes
R3307	T4233	T4231	prep	for,minutes
R3308	T4234	T4235	det	a,total
R3309	T4235	T4233	pobj	total,for
R3310	T4236	T4235	prep	of,total
R3311	T4237	T4238	nummod	40,minutes
R3312	T4238	T4236	pobj	minutes,of
R3313	T4239	T4223	punct	.,put
R3314	T4240	T4241	det	The,tubes
R3315	T4241	T4243	nsubjpass	tubes,centrifuged
R3316	T4242	T4243	auxpass	were,centrifuged
R3317	T4243	T4243	ROOT	centrifuged,centrifuged
R3318	T4244	T4243	prep	at,centrifuged
R3319	T4245	T4246	amod	maximum,speed
R3320	T4246	T4244	pobj	speed,at
R3321	T4247	T4251	punct	(,g
R3322	T4248	T4251	nmod	~,g
R3323	T4249	T4251	dep	"16,000",g
R3324	T4250	T4251	nummod	×,g
R3325	T4251	T4246	appos	g,speed
R3326	T4252	T4251	punct	),g
R3327	T4253	T4243	prep	in,centrifuged
R3328	T4254	T4256	det	a,centrifuge
R3329	T4255	T4256	amod	micro,centrifuge
R3330	T4256	T4253	pobj	centrifuge,in
R3331	T4257	T4243	prep	for,centrifuged
R3332	T4258	T4259	nummod	10,minutes
R3333	T4259	T4257	pobj	minutes,for
R3334	T4260	T4243	punct	.,centrifuged
R3335	T4261	T4262	det	The,supernatants
R3336	T4262	T4268	nsubjpass	supernatants,transferred
R3337	T4263	T4262	punct	(,supernatants
R3338	T4264	T4265	amod	nuclear,extract
R3339	T4265	T4262	appos	extract,supernatants
R3340	T4266	T4262	punct	),supernatants
R3341	T4267	T4268	auxpass	were,transferred
R3342	T4268	T4268	ROOT	transferred,transferred
R3343	T4269	T4268	prep	to,transferred
R3344	T4270	T4273	det	a,tube
R3345	T4271	T4273	amod	clean,tube
R3346	T4272	T4273	amod	prechilled,tube
R3347	T4273	T4269	pobj	tube,to
R3348	T4274	T4268	cc	and,transferred
R3349	T4275	T4268	conj	stored,transferred
R3350	T4276	T4275	prep	at,stored
R3351	T4277	T4279	nummod	−,°
R3352	T4278	T4279	nummod	80,°
R3353	T4279	T4276	pobj	°,at
R3354	T4280	T4275	npadvmod	C,stored
R3355	T4281	T4275	prep	until,stored
R3356	T4282	T4281	pobj	use,until
R3357	T4283	T4268	punct	.,transferred
R3358	T4284	T4286	nsubjpass	EMSA,performed
R3359	T4285	T4286	auxpass	was,performed
R3360	T4286	T4286	ROOT	performed,performed
R3361	T4287	T4288	mark	as,described
R3362	T4288	T4286	advcl	described,performed
R3363	T4289	T4290	advmod	previously,[
R3364	T4290	T4292	amod	[,]
R3365	T4291	T4292	nummod	8,]
R3366	T4292	T4288	dobj	],described
R3367	T4293	T4286	punct	.,performed
R3368	T4294	T4296	amod	NFκB,activity
R3369	T4295	T4296	amod	binding,activity
R3370	T4296	T4298	nsubjpass	activity,examined
R3371	T4297	T4298	auxpass	was,examined
R3372	T4298	T4298	ROOT	examined,examined
R3373	T4299	T4298	prep	in,examined
R3374	T4300	T4305	det	a,mixture
R3375	T4301	T4302	nummod	15,μL
R3376	T4302	T4305	compound	μL,mixture
R3377	T4303	T4304	amod	binding,reaction
R3378	T4304	T4305	compound	reaction,mixture
R3379	T4305	T4299	pobj	mixture,in
R3380	T4306	T4305	acl	containing,mixture
R3381	T4307	T4308	nummod	15,μg
R3382	T4308	T4317	nmod	μg,]
R3383	T4309	T4308	prep	of,μg
R3384	T4310	T4311	amod	nuclear,proteins
R3385	T4311	T4309	pobj	proteins,of
R3386	T4312	T4311	cc	and,proteins
R3387	T4313	T4314	nummod	35,fmol
R3388	T4314	T4317	compound	fmol,]
R3389	T4315	T4317	compound	[,]
R3390	T4316	T4317	compound	γ-32P,]
R3391	T4317	T4306	dobj	],containing
R3392	T4318	T4298	conj	labeled,examined
R3393	T4319	T4322	amod	double-stranded,oligonucleotide
R3394	T4320	T4321	compound	NFκB,consensus
R3395	T4321	T4322	compound	consensus,oligonucleotide
R3396	T4322	T4318	oprd	oligonucleotide,labeled
R3397	T4323	T4298	punct	.,examined
R3398	T4324	T4327	det	A,assay
R3399	T4325	T4326	amod	super,shift
R3400	T4326	T4327	compound	shift,assay
R3401	T4327	T4335	nsubjpass	assay,performed
R3402	T4328	T4327	acl	using,assay
R3403	T4329	T4328	dobj	antibodies,using
R3404	T4330	T4328	prep	to,using
R3405	T4331	T4330	pobj	P65,to
R3406	T4332	T4331	cc	and,P65
R3407	T4333	T4331	conj	P50,P65
R3408	T4334	T4335	auxpass	was,performed
R3409	T4335	T4335	ROOT	performed,performed
R3410	T4336	T4337	aux	to,confirm
R3411	T4337	T4335	xcomp	confirm,performed
R3412	T4338	T4340	nmod	NFκB,specificity
R3413	T4339	T4340	amod	binding,specificity
R3414	T4340	T4337	dobj	specificity,confirm
R3415	T4341	T4343	mark	as,described
R3416	T4342	T4343	advmod	previously,described
R3417	T4343	T4340	advcl	described,specificity
R3418	T4344	T4335	punct	.,performed
R3459	T4426	T4426	ROOT	2.7,2.7
R3460	T4427	T4426	punct	.,2.7
R3461	T4428	T4429	compound	Statistical,Analysis
R3462	T4429	T4430	compound	Analysis,All
R3463	T4430	T4431	compound	All,data
R3464	T4431	T4433	nsubjpass	data,presented
R3465	T4432	T4433	auxpass	were,presented
R3466	T4433	T4433	ROOT	presented,presented
R3467	T4434	T4433	prep	as,presented
R3468	T4435	T4437	amod	mean,SEM
R3469	T4436	T4437	compound	±,SEM
R3470	T4437	T4434	pobj	SEM,as
R3471	T4438	T4433	punct	.,presented
R3472	T4439	T4440	det	The,measurements
R3473	T4440	T4442	nsubjpass	measurements,analyzed
R3474	T4441	T4442	auxpass	were,analyzed
R3475	T4442	T4442	ROOT	analyzed,analyzed
R3476	T4443	T4442	agent	by,analyzed
R3477	T4444	T4445	amod	one-way,analysis
R3478	T4445	T4443	pobj	analysis,by
R3479	T4446	T4445	prep	of,analysis
R3480	T4447	T4446	pobj	variance,of
R3481	T4448	T4449	punct	(,ANOVA
R3482	T4449	T4447	appos	ANOVA,variance
R3483	T4450	T4449	punct	),ANOVA
R3484	T4451	T4447	cc	or,variance
R3485	T4452	T4454	poss	Student,t-test
R3486	T4453	T4452	case	's,Student
R3487	T4454	T4442	npadvmod	t-test,analyzed
R3488	T4455	T4442	punct	.,analyzed
R3489	T4456	T4460	det	The,level
R3490	T4457	T4460	nmod	P,level
R3491	T4458	T4460	nmod	<,level
R3492	T4459	T4458	nummod	.05,<
R3493	T4460	T4464	nsubjpass	level,used
R3494	T4461	T4460	prep	of,level
R3495	T4462	T4461	pobj	probability,of
R3496	T4463	T4464	auxpass	was,used
R3497	T4464	T4464	ROOT	used,used
R3498	T4465	T4464	prep	as,used
R3499	T4466	T4467	det	the,criteria
R3500	T4467	T4465	pobj	criteria,as
R3501	T4468	T4467	prep	of,criteria
R3502	T4469	T4468	pobj	significance,of
R3503	T4470	T4464	punct	.,used
R3625	T4653	T4653	ROOT	3.1,3.1
R3626	T4654	T4653	punct	.,3.1
R3627	T4655	T4656	nummod	TLR4,mRNA
R3628	T4656	T4657	nsubj	mRNA,Increased
R3629	T4657	T4657	ROOT	Increased,Increased
R3630	T4658	T4657	prep	in,Increased
R3631	T4659	T4660	compound	Brain,Tissue
R3632	T4660	T4658	pobj	Tissue,in
R3633	T4661	T4667	mark	after,detected
R3634	T4662	T4665	nmod	ICH,levels
R3635	T4663	T4665	nummod	TLR4,levels
R3636	T4664	T4665	compound	mRNA,levels
R3637	T4665	T4667	nsubjpass	levels,detected
R3638	T4666	T4667	auxpass	were,detected
R3639	T4667	T4657	advcl	detected,Increased
R3640	T4668	T4667	agent	by,detected
R3641	T4669	T4668	pobj	Rt-PCR,by
R3642	T4670	T4657	punct	.,Increased
R3643	T4671	T4673	det	The,level
R3644	T4672	T4673	amod	low,level
R3645	T4673	T4678	nsubjpass	level,observed
R3646	T4674	T4673	prep	of,level
R3647	T4675	T4676	nummod	TLR4,mRNA
R3648	T4676	T4674	pobj	mRNA,of
R3649	T4677	T4678	auxpass	was,observed
R3650	T4678	T4678	ROOT	observed,observed
R3651	T4679	T4678	prep	in,observed
R3652	T4680	T4683	amod	normal,tissue
R3653	T4681	T4683	compound	rat,tissue
R3654	T4682	T4683	compound	brain,tissue
R3655	T4683	T4679	pobj	tissue,in
R3656	T4684	T4678	punct	.,observed
R3657	T4685	T4695	prep	In,increased
R3658	T4686	T4689	det	the,group
R3659	T4687	T4689	amod	saline,group
R3660	T4688	T4689	compound	control,group
R3661	T4689	T4685	pobj	group,In
R3662	T4690	T4695	punct	",",increased
R3663	T4691	T4695	det	the,increased
R3664	T4692	T4695	nummod	TLR4,increased
R3665	T4693	T4695	nsubj	mRNA,increased
R3666	T4694	T4695	advmod	slightly,increased
R3667	T4695	T4695	ROOT	increased,increased
R3668	T4696	T4695	punct	",",increased
R3669	T4697	T4695	cc	but,increased
R3670	T4698	T4695	conj	was,increased
R3671	T4699	T4698	neg	not,was
R3672	T4700	T4701	advmod	significantly,different
R3673	T4701	T4698	acomp	different,was
R3674	T4702	T4701	prep	from,different
R3675	T4703	T4704	amod	normal,group
R3676	T4704	T4702	pobj	group,from
R3677	T4705	T4695	punct	.,increased
R3678	T4706	T4727	advmod	However,peaked
R3679	T4707	T4727	punct	",",peaked
R3680	T4708	T4710	det	the,mRNA
R3681	T4709	T4710	compound	TLR4,mRNA
R3682	T4710	T4727	nsubj	mRNA,peaked
R3683	T4711	T4714	mark	after,increased
R3684	T4712	T4714	nsubj	ICH,increased
R3685	T4713	T4714	advmod	significantly,increased
R3686	T4714	T4727	advcl	increased,peaked
R3687	T4715	T4727	advcl	starting,peaked
R3688	T4716	T4715	prep	from,starting
R3689	T4717	T4718	nummod	6,hours
R3690	T4718	T4716	pobj	hours,from
R3691	T4719	T4727	mark	after,peaked
R3692	T4720	T4727	nsubj	ICH,peaked
R3693	T4721	T4720	punct	(,ICH
R3694	T4722	T4725	nmod	P,)
R3695	T4723	T4724	nummod	<,.05
R3696	T4724	T4722	appos	.05,P
R3697	T4725	T4720	punct	),ICH
R3698	T4726	T4727	punct	",",peaked
R3699	T4727	T4727	ROOT	peaked,peaked
R3700	T4728	T4727	prep	on,peaked
R3701	T4729	T4731	det	the,day
R3702	T4730	T4731	amod	3rd,day
R3703	T4731	T4728	pobj	day,on
R3704	T4732	T4731	prep	after,day
R3705	T4733	T4732	pobj	ICH,after
R3706	T4734	T4727	punct	",",peaked
R3707	T4735	T4727	cc	and,peaked
R3708	T4736	T4737	advmod	then,decreased
R3709	T4737	T4727	conj	decreased,peaked
R3710	T4738	T4737	prep	on,decreased
R3711	T4739	T4741	det	the,day
R3712	T4740	T4741	amod	7th,day
R3713	T4741	T4738	pobj	day,on
R3714	T4742	T4741	prep	after,day
R3715	T4743	T4742	pobj	ICH,after
R3716	T4744	T4743	punct	(,ICH
R3717	T4745	T4743	appos	P,ICH
R3718	T4746	T4745	nummod	<,P
R3719	T4747	T4745	appos	.05,P
R3720	T4748	T4745	punct	),P
R3721	T4749	T4743	punct	",",ICH
R3722	T4750	T4737	cc	but,decreased
R3723	T4751	T4752	advmod	still,maintained
R3724	T4752	T4737	conj	maintained,decreased
R3725	T4753	T4755	det	a,level
R3726	T4754	T4755	amod	higher,level
R3727	T4755	T4752	dobj	level,maintained
R3728	T4756	T4755	prep	compared,level
R3729	T4757	T4756	prep	with,compared
R3730	T4758	T4759	compound	saline,control
R3731	T4759	T4757	pobj	control,with
R3732	T4760	T4759	punct	(,control
R3733	T4761	T4765	nmod	P,Figure
R3734	T4762	T4761	nummod	<,P
R3735	T4763	T4761	nummod	.05,P
R3736	T4764	T4765	punct	",",Figure
R3737	T4765	T4759	appos	Figure,control
R3738	T4766	T4765	nummod	1,Figure
R3739	T4767	T4759	punct	),control
R3740	T4768	T4727	punct	.,peaked
R3930	T5083	T5083	ROOT	3.2,3.2
R3931	T5084	T5083	punct	.,3.2
R3932	T5085	T5089	nsubj	Expression,Increased
R3933	T5086	T5085	prep	of,Expression
R3934	T5087	T5088	nummod	TLR4,Protein
R3935	T5088	T5086	pobj	Protein,of
R3936	T5089	T5089	ROOT	Increased,Increased
R3937	T5090	T5089	prep	in,Increased
R3938	T5091	T5092	compound	Brain,Tissue
R3939	T5092	T5090	pobj	Tissue,in
R3940	T5093	T5096	mark	after,investigate
R3941	T5094	T5096	nsubj	ICH,investigate
R3942	T5095	T5096	aux	To,investigate
R3943	T5096	T5089	advcl	investigate,Increased
R3944	T5097	T5099	det	the,TLR4
R3945	T5098	T5099	amod	increased,TLR4
R3946	T5099	T5096	dobj	TLR4,investigate
R3947	T5100	T5096	prep	at,investigate
R3948	T5101	T5103	det	the,level
R3949	T5102	T5103	compound	protein,level
R3950	T5103	T5100	pobj	level,at
R3951	T5104	T5096	punct	",",investigate
R3952	T5105	T5106	det	the,expression
R3953	T5106	T5096	dobj	expression,investigate
R3954	T5107	T5106	prep	of,expression
R3955	T5108	T5109	nummod	TLR4,protein
R3956	T5109	T5107	pobj	protein,of
R3957	T5110	T5111	auxpass	was,measured
R3958	T5111	T5096	conj	measured,investigate
R3959	T5112	T5111	prep	in,measured
R3960	T5113	T5114	compound	brain,tissue
R3961	T5114	T5112	pobj	tissue,in
R3962	T5115	T5111	agent	by,measured
R3963	T5116	T5117	det	the,method
R3964	T5117	T5115	pobj	method,by
R3965	T5118	T5117	prep	of,method
R3966	T5119	T5120	amod	Western,Blots
R3967	T5120	T5118	pobj	Blots,of
R3968	T5121	T5111	advcl	using,measured
R3969	T5122	T5123	amod	specific,antibodies
R3970	T5123	T5121	dobj	antibodies,using
R3971	T5124	T5121	prep	for,using
R3972	T5125	T5124	pobj	TLR4,for
R3973	T5126	T5089	punct	.,Increased
R3974	T5127	T5128	poss	Our,results
R3975	T5128	T5129	nsubj	results,showed
R3976	T5129	T5129	ROOT	showed,showed
R3977	T5130	T5137	mark	that,was
R3978	T5131	T5133	det	a,level
R3979	T5132	T5133	amod	low,level
R3980	T5133	T5137	nsubj	level,was
R3981	T5134	T5133	prep	of,level
R3982	T5135	T5136	nummod	TLR4,protein
R3983	T5136	T5134	pobj	protein,of
R3984	T5137	T5129	ccomp	was,showed
R3985	T5138	T5137	acomp	detectable,was
R3986	T5139	T5138	prep	in,detectable
R3987	T5140	T5143	det	the,group
R3988	T5141	T5142	compound	saline,control
R3989	T5142	T5143	compound	control,group
R3990	T5143	T5139	pobj	group,in
R3991	T5144	T5129	punct	.,showed
R3992	T5145	T5146	det	The,expression
R3993	T5146	T5150	nsubj	expression,increased
R3994	T5147	T5146	prep	of,expression
R3995	T5148	T5147	pobj	TLR4,of
R3996	T5149	T5150	advmod	significantly,increased
R3997	T5150	T5150	ROOT	increased,increased
R3998	T5151	T5150	xcomp	starting,increased
R3999	T5152	T5151	prep	from,starting
R4000	T5153	T5154	nummod	6,hours
R4001	T5154	T5152	pobj	hours,from
R4002	T5155	T5163	mark	after,peaked
R4003	T5156	T5163	nsubj	ICH,peaked
R4004	T5157	T5156	punct	(,ICH
R4005	T5158	T5161	nmod	P,)
R4006	T5159	T5158	nummod	<,P
R4007	T5160	T5158	nummod	.05,P
R4008	T5161	T5156	punct	),ICH
R4009	T5162	T5163	punct	",",peaked
R4010	T5163	T5151	advcl	peaked,starting
R4011	T5164	T5163	prep	on,peaked
R4012	T5165	T5167	det	the,day
R4013	T5166	T5167	amod	3rd,day
R4014	T5167	T5164	pobj	day,on
R4015	T5168	T5167	prep	after,day
R4016	T5169	T5168	pobj	ICH,after
R4017	T5170	T5163	punct	",",peaked
R4018	T5171	T5150	cc	and,increased
R4019	T5172	T5173	advmod	then,decreased
R4020	T5173	T5150	conj	decreased,increased
R4021	T5174	T5173	cc	but,decreased
R4022	T5175	T5176	advmod	still,maintained
R4023	T5176	T5173	conj	maintained,decreased
R4024	T5177	T5176	prep	at,maintained
R4025	T5178	T5180	det	a,level
R4026	T5179	T5180	amod	high,level
R4027	T5180	T5177	pobj	level,at
R4028	T5181	T5180	prep	on,level
R4029	T5182	T5184	det	the,day
R4030	T5183	T5184	amod	7th,day
R4031	T5184	T5181	pobj	day,on
R4032	T5185	T5184	prep	after,day
R4033	T5186	T5194	nmod	ICH,)
R4034	T5187	T5188	punct	(,P
R4035	T5188	T5194	nmod	P,)
R4036	T5189	T5188	nummod	<,P
R4037	T5190	T5188	nummod	.05,P
R4038	T5191	T5192	punct	",",Figure
R4039	T5192	T5194	nmod	Figure,)
R4040	T5193	T5192	nummod	2,Figure
R4041	T5194	T5180	punct	),level
R4042	T5195	T5150	punct	.,increased
R4043	T5196	T5197	det	This,observation
R4044	T5197	T5201	nsubj	observation,was
R4045	T5198	T5197	prep	of,observation
R4046	T5199	T5200	nummod	TLR4,protein
R4047	T5200	T5198	pobj	protein,of
R4048	T5201	T5201	ROOT	was,was
R4049	T5202	T5201	acomp	consistent,was
R4050	T5203	T5202	prep	with,consistent
R4051	T5204	T5206	det	the,profile
R4052	T5205	T5206	amod	temporal,profile
R4053	T5206	T5203	pobj	profile,with
R4054	T5207	T5206	prep	of,profile
R4055	T5208	T5210	det	the,mRNA
R4056	T5209	T5210	nummod	TLR4,mRNA
R4057	T5210	T5207	pobj	mRNA,of
R4058	T5211	T5201	prep	after,was
R4059	T5212	T5211	pobj	ICH,after
R4060	T5213	T5201	punct	.,was
R4179	T5462	T5462	ROOT	3.3,3.3
R4180	T5463	T5462	punct	.,3.3
R4181	T5464	T5483	advcl	Distribution,detected
R4182	T5465	T5464	prep	of,Distribution
R4183	T5466	T5465	pobj	TLR4,of
R4184	T5467	T5464	prep	in,Distribution
R4185	T5468	T5469	compound	Brain,Subjected
R4186	T5469	T5467	pobj	Subjected,in
R4187	T5470	T5464	prep	to,Distribution
R4188	T5471	T5470	pobj	ICH,to
R4189	T5472	T5473	aux	To,explore
R4190	T5473	T5464	advcl	explore,Distribution
R4191	T5474	T5475	det	the,distribution
R4192	T5475	T5473	dobj	distribution,explore
R4193	T5476	T5475	prep	of,distribution
R4194	T5477	T5478	nummod	TLR4,protein
R4195	T5478	T5476	pobj	protein,of
R4196	T5479	T5483	punct	",",detected
R4197	T5480	T5481	det	the,TLR4
R4198	T5481	T5483	nsubjpass	TLR4,detected
R4199	T5482	T5483	auxpass	was,detected
R4200	T5483	T5483	ROOT	detected,detected
R4201	T5484	T5483	agent	by,detected
R4202	T5485	T5484	pobj	immunohistochemistry,by
R4203	T5486	T5487	punct	(,IHC
R4204	T5487	T5485	appos	IHC,immunohistochemistry
R4205	T5488	T5487	punct	),IHC
R4206	T5489	T5483	punct	.,detected
R4207	T5490	T5491	nsubj	Results,showed
R4208	T5491	T5491	ROOT	showed,showed
R4209	T5492	T5495	mark	that,was
R4210	T5493	T5494	nummod	TLR4,immunoreactivity
R4211	T5494	T5495	nsubj	immunoreactivity,was
R4212	T5495	T5491	ccomp	was,showed
R4213	T5496	T5495	neg	not,was
R4214	T5497	T5495	acomp	detectable,was
R4215	T5498	T5497	prep	in,detectable
R4216	T5499	T5500	compound	brain,tissue
R4217	T5500	T5498	pobj	tissue,in
R4218	T5501	T5500	prep	from,tissue
R4219	T5502	T5505	amod	normal,control
R4220	T5503	T5502	cc	and,normal
R4221	T5504	T5502	conj	sham,normal
R4222	T5505	T5501	pobj	control,from
R4223	T5506	T5491	punct	.,showed
R4224	T5507	T5514	advmod	However,demonstrated
R4225	T5508	T5514	punct	",",demonstrated
R4226	T5509	T5514	nsubjpass	immunoreactivity,demonstrated
R4227	T5510	T5509	prep	for,immunoreactivity
R4228	T5511	T5510	pobj	TLR4,for
R4229	T5512	T5514	auxpass	was,demonstrated
R4230	T5513	T5514	advmod	consistently,demonstrated
R4231	T5514	T5514	ROOT	demonstrated,demonstrated
R4232	T5515	T5514	prep	in,demonstrated
R4233	T5516	T5517	amod	peri-hemorrhage,areas
R4234	T5517	T5515	pobj	areas,in
R4235	T5518	T5514	punct	",",demonstrated
R4236	T5519	T5520	det	the,hippocampus
R4237	T5520	T5514	dobj	hippocampus,demonstrated
R4238	T5521	T5520	punct	",",hippocampus
R4239	T5522	T5520	conj	cortex,hippocampus
R4240	T5523	T5522	punct	",",cortex
R4241	T5524	T5525	amod	thalamic,nuclei
R4242	T5525	T5522	conj	nuclei,cortex
R4243	T5526	T5525	punct	",",nuclei
R4244	T5527	T5525	cc	and,nuclei
R4245	T5528	T5531	det	some,tracts
R4246	T5529	T5530	amod	white,matter
R4247	T5530	T5531	compound	matter,tracts
R4248	T5531	T5525	conj	tracts,nuclei
R4249	T5532	T5533	punct	(,Figure
R4250	T5533	T5531	parataxis	Figure,tracts
R4251	T5534	T5533	nummod	3,Figure
R4252	T5535	T5533	punct	),Figure
R4253	T5536	T5514	punct	.,demonstrated
R4422	T5807	T5807	ROOT	3.4,3.4
R4423	T5808	T5807	punct	.,3.4
R4424	T5809	T5817	nsubj	Activation,induces
R4425	T5810	T5809	prep	of,Activation
R4426	T5811	T5812	compound	TLR4-Mediated,NF-Kappa-B
R4427	T5812	T5810	pobj	NF-Kappa-B,of
R4428	T5813	T5814	compound	Signaling,Activation
R4429	T5814	T5809	conj	Activation,Activation
R4430	T5815	T5814	prep	of,Activation
R4431	T5816	T5815	pobj	TLR4,of
R4432	T5817	T5817	ROOT	induces,induces
R4433	T5818	T5819	det	the,phosphorylation
R4434	T5819	T5817	dobj	phosphorylation,induces
R4435	T5820	T5819	prep	of,phosphorylation
R4436	T5821	T5820	pobj	inhibitor,of
R4437	T5822	T5821	prep	of,inhibitor
R4438	T5823	T5822	pobj	kappa-B,of
R4439	T5824	T5823	punct	(,kappa-B
R4440	T5825	T5823	appos	IκB,kappa-B
R4441	T5826	T5823	punct	),kappa-B
R4442	T5827	T5823	punct	",",kappa-B
R4443	T5828	T5829	nsubj	which,dissociates
R4444	T5829	T5823	relcl	dissociates,kappa-B
R4445	T5830	T5829	dobj	IκB,dissociates
R4446	T5831	T5829	prep	with,dissociates
R4447	T5832	T5831	pobj	NF-kappa-B,with
R4448	T5833	T5832	punct	(,NF-kappa-B
R4449	T5834	T5832	appos	NFκB,NF-kappa-B
R4450	T5835	T5832	punct	),NF-kappa-B
R4451	T5836	T5817	punct	.,induces
R4452	T5837	T5840	advmod	Then,translocates
R4453	T5838	T5840	punct	",",translocates
R4454	T5839	T5840	nsubj	NFκB,translocates
R4455	T5840	T5840	ROOT	translocates,translocates
R4456	T5841	T5840	prep	into,translocates
R4457	T5842	T5843	det	the,nucleus
R4458	T5843	T5841	pobj	nucleus,into
R4459	T5844	T5840	cc	and,translocates
R4460	T5845	T5840	conj	activates,translocates
R4461	T5846	T5845	cc	and,activates
R4462	T5847	T5845	conj	regulates,activates
R4463	T5848	T5849	det	the,transcription
R4464	T5849	T5847	dobj	transcription,regulates
R4465	T5850	T5849	prep	of,transcription
R4466	T5851	T5850	pobj	genes,of
R4467	T5852	T5851	acl	related,genes
R4468	T5853	T5852	prep	to,related
R4469	T5854	T5855	amod	inflammatory,responses
R4470	T5855	T5853	pobj	responses,to
R4471	T5856	T5840	punct	.,translocates
R4472	T5857	T5858	aux	To,detectd
R4473	T5858	T5880	advcl	detectd,measured
R4474	T5859	T5860	det	the,activation
R4475	T5860	T5858	dobj	activation,detectd
R4476	T5861	T5860	prep	of,activation
R4477	T5862	T5863	compound	TLR4-mediated,NFκB
R4478	T5863	T5861	pobj	NFκB,of
R4479	T5864	T5860	acl	signaling,activation
R4480	T5865	T5880	punct	",",measured
R4481	T5866	T5867	det	the,phosphorylation
R4482	T5867	T5880	nsubjpass	phosphorylation,measured
R4483	T5868	T5867	prep	of,phosphorylation
R4484	T5869	T5868	pobj	inhibitor,of
R4485	T5870	T5869	prep	of,inhibitor
R4486	T5871	T5870	pobj	kappa-B,of
R4487	T5872	T5871	punct	(,kappa-B
R4488	T5873	T5871	appos	p-IκB,kappa-B
R4489	T5874	T5871	punct	),kappa-B
R4490	T5875	T5869	cc	and,inhibitor
R4491	T5876	T5869	conj	activity,inhibitor
R4492	T5877	T5869	prep	of,inhibitor
R4493	T5878	T5877	pobj	NFκB,of
R4494	T5879	T5880	auxpass	were,measured
R4495	T5880	T5880	ROOT	measured,measured
R4496	T5881	T5880	agent	by,measured
R4497	T5882	T5881	pobj	methods,by
R4498	T5883	T5882	prep	of,methods
R4499	T5884	T5885	amod	Western,Blots
R4500	T5885	T5883	pobj	Blots,of
R4501	T5886	T5885	cc	and,Blots
R4502	T5887	T5885	conj	EMSA,Blots
R4503	T5888	T5880	punct	.,measured
R4504	T5889	T5890	nsubj	Results,showed
R4505	T5890	T5890	ROOT	showed,showed
R4506	T5891	T5894	mark	that,increased
R4507	T5892	T5893	det	the,p-IκB
R4508	T5893	T5894	nsubj	p-IκB,increased
R4509	T5894	T5890	ccomp	increased,showed
R4510	T5895	T5894	prep	at,increased
R4511	T5896	T5897	nummod	6,hours
R4512	T5897	T5895	pobj	hours,at
R4513	T5898	T5906	mark	after,peaked
R4514	T5899	T5906	nsubj	ICH,peaked
R4515	T5900	T5899	punct	(,ICH
R4516	T5901	T5904	nmod	P,)
R4517	T5902	T5903	nummod	<,.05
R4518	T5903	T5901	appos	.05,P
R4519	T5904	T5899	punct	),ICH
R4520	T5905	T5906	punct	",",peaked
R4521	T5906	T5894	advcl	peaked,increased
R4522	T5907	T5906	prep	on,peaked
R4523	T5908	T5909	nummod	3,days
R4524	T5909	T5907	pobj	days,on
R4525	T5910	T5906	prep	after,peaked
R4526	T5911	T5910	pobj	ICH,after
R4527	T5912	T5906	punct	",",peaked
R4528	T5913	T5906	cc	and,peaked
R4529	T5914	T5906	conj	maintained,peaked
R4530	T5915	T5917	det	a,level
R4531	T5916	T5917	amod	high,level
R4532	T5917	T5914	dobj	level,maintained
R4533	T5918	T5914	prep	on,maintained
R4534	T5919	T5920	nummod	7,days
R4535	T5920	T5918	pobj	days,on
R4536	T5921	T5914	prep	after,maintained
R4537	T5922	T5924	nmod	ICH,P
R4538	T5923	T5922	punct	(,ICH
R4539	T5924	T5921	pobj	P,after
R4540	T5925	T5926	nummod	<,.05
R4541	T5926	T5924	prep	.05,P
R4542	T5927	T5928	punct	",",Figure
R4543	T5928	T5924	appos	Figure,P
R4544	T5929	T5928	nummod	5,Figure
R4545	T5930	T5928	punct	),Figure
R4546	T5931	T5890	punct	.,showed
R4547	T5932	T5933	mark	As,expected
R4548	T5933	T5941	advcl	expected,increased
R4549	T5934	T5941	punct	",",increased
R4550	T5935	T5936	det	the,activity
R4551	T5936	T5941	nsubjpass	activity,increased
R4552	T5937	T5936	prep	of,activity
R4553	T5938	T5937	pobj	NFκB,of
R4554	T5939	T5941	auxpass	was,increased
R4555	T5940	T5941	advmod	also,increased
R4556	T5941	T5941	ROOT	increased,increased
R4557	T5942	T5941	prep	in,increased
R4558	T5943	T5945	det	the,manner
R4559	T5944	T5945	amod	same,manner
R4560	T5945	T5942	pobj	manner,in
R4561	T5946	T5945	prep	as,manner
R4562	T5947	T5946	pobj	that,as
R4563	T5948	T5947	prep	of,that
R4564	T5949	T5950	det	the,p-IκB
R4565	T5950	T5948	pobj	p-IκB,of
R4566	T5951	T5952	punct	(,Figure
R4567	T5952	T5947	appos	Figure,that
R4568	T5953	T5952	nummod	4,Figure
R4569	T5954	T5952	punct	),Figure
R4570	T5955	T5941	punct	.,increased
R5777	T7577	T7578	amod	Intra-cerebral,hemorrhage
R5778	T7578	T7582	nsubj	hemorrhage,represents
R5779	T7579	T7580	punct	(,ICH
R5780	T7580	T7578	appos	ICH,hemorrhage
R5781	T7581	T7578	punct	),hemorrhage
R5782	T7582	T7582	ROOT	represents,represents
R5783	T7583	T7582	dobj	10,represents
R5784	T7584	T7585	nummod	15,%
R5785	T7585	T7583	appos	%,10
R5786	T7586	T7585	prep	of,%
R5787	T7587	T7588	det	all,strokes
R5788	T7588	T7586	pobj	strokes,of
R5789	T7589	T7582	punct	",",represents
R5790	T7590	T7582	cc	and,represents
R5791	T7591	T7582	conj	occurs,represents
R5792	T7592	T7591	prep	with,occurs
R5793	T7593	T7594	amod	increasing,frequency
R5794	T7594	T7592	pobj	frequency,with
R5795	T7595	T7594	prep	as,frequency
R5796	T7596	T7597	det	a,complication
R5797	T7597	T7595	pobj	complication,as
R5798	T7598	T7597	prep	of,complication
R5799	T7599	T7601	det	the,treatment
R5800	T7600	T7601	compound	thrombolytic,treatment
R5801	T7601	T7598	pobj	treatment,of
R5802	T7602	T7601	prep	of,treatment
R5803	T7603	T7604	amod	ischemic,stroke
R5804	T7604	T7602	pobj	stroke,of
R5805	T7605	T7607	nmod	[,]
R5806	T7606	T7607	nummod	1,]
R5807	T7607	T7597	appos	],complication
R5808	T7608	T7582	punct	.,represents
R5809	T7609	T7610	det	The,mortality
R5810	T7610	T7613	nsubj	mortality,is
R5811	T7611	T7610	prep	of,mortality
R5812	T7612	T7611	pobj	ICH,of
R5813	T7613	T7613	ROOT	is,is
R5814	T7614	T7613	acomp	higher,is
R5815	T7615	T7614	prep	than,higher
R5816	T7616	T7615	pobj	that,than
R5817	T7617	T7616	prep	of,that
R5818	T7618	T7619	amod	ischemic,stroke
R5819	T7619	T7617	pobj	stroke,of
R5820	T7620	T7613	punct	.,is
R5821	T7621	T7622	advmod	Only,31
R5822	T7622	T7623	nummod	31,%
R5823	T7623	T7624	nsubj	%,are
R5824	T7624	T7624	ROOT	are,are
R5825	T7625	T7626	advmod	functionally,independent
R5826	T7626	T7624	acomp	independent,are
R5827	T7627	T7624	prep	at,are
R5828	T7628	T7629	nummod	3,months
R5829	T7629	T7627	pobj	months,at
R5830	T7630	T7624	punct	.,are
R5831	T7631	T7632	advmod	Only,38
R5832	T7632	T7633	nummod	38,%
R5833	T7633	T7637	nsubj	%,survive
R5834	T7634	T7633	prep	of,%
R5835	T7635	T7636	det	the,patients
R5836	T7636	T7634	pobj	patients,of
R5837	T7637	T7637	ROOT	survive,survive
R5838	T7638	T7640	det	the,year
R5839	T7639	T7640	amod	1st,year
R5840	T7640	T7637	dobj	year,survive
R5841	T7641	T7643	nmod	[,]
R5842	T7642	T7643	nummod	10,]
R5843	T7643	T7640	appos	],year
R5844	T7644	T7637	punct	.,survive
R5845	T7645	T7662	advmod	Unfortunately,are
R5846	T7646	T7662	punct	",",are
R5847	T7647	T7648	det	the,method
R5848	T7648	T7662	nsubj	method,are
R5849	T7649	T7648	prep	for,method
R5850	T7650	T7649	pobj	treatment,for
R5851	T7651	T7650	prep	of,treatment
R5852	T7652	T7653	det	this,disease
R5853	T7653	T7651	pobj	disease,of
R5854	T7654	T7653	cc	and,disease
R5855	T7655	T7653	conj	protection,disease
R5856	T7656	T7655	prep	of,protection
R5857	T7657	T7659	det	the,tissue
R5858	T7658	T7659	compound	brain,tissue
R5859	T7659	T7656	pobj	tissue,of
R5860	T7660	T7648	prep	after,method
R5861	T7661	T7660	pobj	ICH,after
R5862	T7662	T7662	ROOT	are,are
R5863	T7663	T7662	neg	not,are
R5864	T7664	T7662	acomp	effective,are
R5865	T7665	T7662	punct	.,are
R5866	T7666	T7667	compound	Mass,effect
R5867	T7667	T7667	ROOT	effect,effect
R5868	T7668	T7669	punct	",",ischemia
R5869	T7669	T7667	conj	ischemia,effect
R5870	T7670	T7669	punct	",",ischemia
R5871	T7671	T7669	cc	and,ischemia
R5872	T7672	T7669	conj	toxicity,ischemia
R5873	T7673	T7672	prep	of,toxicity
R5874	T7674	T7675	compound	blood,components
R5875	T7675	T7673	pobj	components,of
R5876	T7676	T7678	mark	after,induce
R5877	T7677	T7678	nsubj	ICH,induce
R5878	T7678	T7667	advcl	induce,effect
R5879	T7679	T7681	compound	brain,damage
R5880	T7680	T7681	compound	tissue,damage
R5881	T7681	T7678	dobj	damage,induce
R5882	T7682	T7667	punct	.,effect
R5883	T7683	T7688	prep	In,increasing
R5884	T7684	T7683	pobj	addition,In
R5885	T7685	T7688	punct	",",increasing
R5886	T7686	T7687	expl	there,is
R5887	T7687	T7688	aux	is,increasing
R5888	T7688	T7688	ROOT	increasing,increasing
R5889	T7689	T7688	dobj	evidence,increasing
R5890	T7690	T7694	mark	that,involved
R5891	T7691	T7692	amod	inflammatory,processes
R5892	T7692	T7694	nsubjpass	processes,involved
R5893	T7693	T7694	auxpass	are,involved
R5894	T7694	T7689	acl	involved,evidence
R5895	T7695	T7694	prep	in,involved
R5896	T7696	T7697	amod	cerebrovascular,events
R5897	T7697	T7695	pobj	events,in
R5898	T7698	T7688	punct	.,increasing
R5899	T7699	T7708	prep	After,enter
R5900	T7700	T7699	pobj	ICH,After
R5901	T7701	T7708	punct	",",enter
R5902	T7702	T7703	amod	inflammatory,mediators
R5903	T7703	T7708	nsubj	mediators,enter
R5904	T7704	T7703	prep	from,mediators
R5905	T7705	T7706	det	the,blood
R5906	T7706	T7704	pobj	blood,from
R5907	T7707	T7708	aux	might,enter
R5908	T7708	T7708	ROOT	enter,enter
R5909	T7709	T7708	prep	to,enter
R5910	T7710	T7711	det	the,brain
R5911	T7711	T7709	pobj	brain,to
R5912	T7712	T7708	cc	and,enter
R5913	T7713	T7708	conj	induce,enter
R5914	T7714	T7716	det	an,reaction
R5915	T7715	T7716	amod	inflammatory,reaction
R5916	T7716	T7713	dobj	reaction,induce
R5917	T7717	T7716	cc	and,reaction
R5918	T7718	T7720	det	the,cells
R5919	T7719	T7720	compound	brain,cells
R5920	T7720	T7716	conj	cells,reaction
R5921	T7721	T7720	appos	itself,cells
R5922	T7722	T7708	conj	are,enter
R5923	T7723	T7722	advmod	also,are
R5924	T7724	T7722	acomp	capable,are
R5925	T7725	T7724	prep	of,capable
R5926	T7726	T7725	pcomp	producing,of
R5927	T7727	T7726	dobj	many,producing
R5928	T7728	T7727	prep	of,many
R5929	T7729	T7730	det	these,agents
R5930	T7730	T7728	pobj	agents,of
R5931	T7731	T7733	nmod	[,]
R5932	T7732	T7733	nummod	11,]
R5933	T7733	T7726	dobj	],producing
R5934	T7734	T7722	punct	.,are
R5935	T7735	T7737	det	The,responses
R5936	T7736	T7737	amod	inflammatory,responses
R5937	T7737	T7738	nsubj	responses,are
R5938	T7807	T7811	nsubj	factor-kappa-B,is
R5939	T7738	T7738	ROOT	are,are
R5940	T7808	T7807	punct	(,factor-kappa-B
R5941	T7739	T7738	acomp	responsible,are
R5942	T7809	T7807	appos	NFκB,factor-kappa-B
R5943	T7810	T7807	punct	),factor-kappa-B
R5944	T7740	T7739	prep	for,responsible
R5945	T7811	T7836	ccomp	is,plays
R5946	T7812	T7816	det	an,factor
R5947	T7813	T7816	amod	important,factor
R5948	T7741	T7742	det	the,ICH
R5949	T7814	T7815	amod	nuclear,transcription
R5950	T7815	T7816	compound	transcription,factor
R5951	T7816	T7811	attr	factor,is
R5952	T7742	T7743	nsubj	ICH,induced
R5953	T7817	T7816	punct	",",factor
R5954	T7818	T7819	nsubj	which,initiates
R5955	T7743	T7738	advcl	induced,are
R5956	T7819	T7816	relcl	initiates,factor
R5957	T7820	T7819	dobj	transcription,initiates
R5958	T7821	T7820	prep	of,transcription
R5959	T7822	T7821	pobj	genes,of
R5960	T7744	T7745	compound	brain,injury
R5961	T7823	T7822	acl	associated,genes
R5962	T7745	T7743	dobj	injury,induced
R5963	T7824	T7823	prep	with,associated
R5964	T7746	T7745	punct	",",injury
R5965	T7825	T7826	amod	immune,responses
R5966	T7826	T7824	pobj	responses,with
R5967	T7747	T7749	nsubj	which,provide
R5968	T7827	T7826	cc	and,responses
R5969	T7828	T7826	conj	inflammation,responses
R5970	T7829	T7833	nmod	[,]
R5971	T7830	T7832	dep	12,13
R5972	T7831	T7832	punct	",",13
R5973	T7832	T7833	nummod	13,]
R5974	T7748	T7749	aux	could,provide
R5975	T7833	T7836	nsubj	],plays
R5976	T7834	T7833	cc	and,]
R5977	T7749	T7745	relcl	provide,injury
R5978	T7835	T7836	advmod	also,plays
R5979	T7836	T7836	ROOT	plays,plays
R5980	T7837	T7839	det	a,role
R5981	T7838	T7839	amod	key,role
R5982	T7750	T7752	amod	new,targets
R5983	T7839	T7836	dobj	role,plays
R5984	T7840	T7839	prep	in,role
R5985	T7841	T7840	pcomp	regulating,in
R5986	T7751	T7752	amod	therapeutic,targets
R5987	T7842	T7841	dobj	inflammation,regulating
R5988	T7843	T7842	prep	in,inflammation
R5989	T7752	T7749	dobj	targets,provide
R5990	T7844	T7845	compound	brain,pathologies
R5991	T7845	T7843	pobj	pathologies,in
R5992	T7846	T7836	punct	.,plays
R5993	T7847	T7850	nsubjpass	It,reported
R5994	T7753	T7752	prep	for,targets
R5995	T7848	T7850	aux	has,reported
R5996	T7849	T7850	auxpass	been,reported
R5997	T7850	T7850	ROOT	reported,reported
R5998	T7754	T7753	pobj	ICH,for
R5999	T7851	T7853	mark	that,increased
R6000	T7852	T7853	nsubj	NFκB,increased
R6001	T7853	T7850	ccomp	increased,reported
R6002	T7755	T7738	punct	.,are
R6003	T7854	T7853	prep	in,increased
R6004	T7855	T7856	det	the,region
R6005	T7856	T7854	pobj	region,in
R6006	T7756	T7757	amod	Various,constituents
R6007	T7857	T7856	prep	of,region
R6008	T7858	T7857	pobj	perihematoma,of
R6009	T7859	T7853	prep	after,increased
R6010	T7757	T7777	nsubj	constituents,be
R6011	T7860	T7861	compound	ICH,[
R6012	T7861	T7859	pobj	[,after
R6013	T7862	T7863	nummod	14,]
R6014	T7758	T7757	prep	of,constituents
R6015	T7863	T7861	appos	],[
R6016	T7864	T7850	punct	.,reported
R6017	T7865	T7866	compound	NFκB,activation
R6018	T7866	T7867	nsubj	activation,occurs
R6019	T7867	T7867	ROOT	occurs,occurs
R6020	T7868	T7867	prep	within,occurs
R6021	T7869	T7868	pobj	minutes,within
R6022	T7759	T7761	det	the,response
R6023	T7870	T7867	cc	and,occurs
R6024	T7871	T7867	conj	persists,occurs
R6025	T7872	T7871	prep	for,persists
R6026	T7873	T7874	advmod	at,least
R6027	T7760	T7761	amod	inflammatory,response
R6028	T7874	T7875	advmod	least,a
R6029	T7875	T7876	nummod	a,week
R6030	T7761	T7758	pobj	response,of
R6031	T7876	T7872	pobj	week,for
R6032	T7877	T7871	prep	in,persists
R6033	T7878	T7877	pobj	response,in
R6034	T7762	T7757	punct	",",constituents
R6035	T7879	T7878	prep	to,response
R6036	T7880	T7879	pobj	ICH,to
R6037	T7881	T7880	punct	",",ICH
R6038	T7882	T7884	nsubjpass	which,associated
R6039	T7763	T7757	prep	including,constituents
R6040	T7883	T7884	auxpass	is,associated
R6041	T7884	T7880	relcl	associated,ICH
R6042	T7885	T7884	prep	with,associated
R6043	T7764	T7765	compound	adhesion,molecules
R6044	T7886	T7887	det	the,expression
R6045	T7887	T7885	pobj	expression,with
R6046	T7888	T7887	prep	of,expression
R6047	T7765	T7763	pobj	molecules,including
R6048	T7889	T7891	amod	selected,genes
R6049	T7890	T7891	compound	target,genes
R6050	T7891	T7888	pobj	genes,of
R6051	T7766	T7765	punct	",",molecules
R6052	T7892	T7894	nmod	[,]
R6053	T7893	T7894	nummod	15,]
R6054	T7894	T7887	appos	],expression
R6055	T7767	T7765	conj	cytokines,molecules
R6056	T7895	T7867	punct	.,occurs
R6057	T7896	T7899	nsubj	Activation,initiates
R6058	T7897	T7896	prep	of,Activation
R6059	T7768	T7767	punct	",",cytokines
R6060	T7898	T7897	pobj	NFκB,of
R6061	T7899	T7899	ROOT	initiates,initiates
R6062	T7900	T7901	amod	inflammatory,responses
R6063	T7769	T7767	conj	leukocytes,cytokines
R6064	T7901	T7899	dobj	responses,initiates
R6065	T7770	T7769	punct	",",leukocytes
R6066	T7902	T7899	cc	and,initiates
R6067	T7903	T7899	conj	contributes,initiates
R6068	T7771	T7769	conj	immunoglobulins,leukocytes
R6069	T7772	T7771	punct	",",immunoglobulins
R6070	T7904	T7903	prep	to,contributes
R6071	T7773	T7771	cc	and,immunoglobulins
R6072	T7905	T7906	det	the,pathobiology
R6073	T7906	T7904	pobj	pathobiology,to
R6074	T7907	T7906	prep	of,pathobiology
R6075	T7774	T7771	conj	complement,immunoglobulins
R6076	T7908	T7910	amod	perilesional,death
R6077	T7909	T7910	compound	cell,death
R6078	T7775	T7774	punct	",",complement
R6079	T7910	T7907	pobj	death,of
R6080	T7911	T7903	prep	after,contributes
R6081	T7776	T7777	aux	may,be
R6082	T7912	T7915	nmod	ICH,]
R6083	T7913	T7915	nmod	[,]
R6084	T7914	T7915	nummod	16,]
R6085	T7777	T7777	ROOT	be,be
R6086	T7915	T7911	pobj	],after
R6087	T7916	T7899	punct	.,initiates
R6088	T7917	T7923	nsubjpass	Inhibition,shown
R6089	T7778	T7777	acomp	important,be
R6090	T7918	T7917	prep	of,Inhibition
R6091	T7919	T7920	compound	NFκB,activity
R6092	T7920	T7918	pobj	activity,of
R6093	T7779	T7777	prep	in,be
R6094	T7921	T7923	aux	has,shown
R6095	T7922	T7923	auxpass	been,shown
R6096	T7923	T7923	ROOT	shown,shown
R6097	T7780	T7781	det	the,pathogenesis
R6098	T7924	T7925	aux	to,have
R6099	T7925	T7923	xcomp	have,shown
R6100	T7926	T7928	det	a,effect
R6101	T7781	T7779	pobj	pathogenesis,in
R6102	T7927	T7928	amod	therapeutic,effect
R6103	T7928	T7925	dobj	effect,have
R6104	T7929	T7928	prep	on,effect
R6105	T7782	T7781	prep	of,pathogenesis
R6106	T7930	T7931	amod	experimental,ICH
R6107	T7931	T7929	pobj	ICH,on
R6108	T7932	T7928	punct	",",effect
R6109	T7783	T7782	pobj	ICH,of
R6110	T7933	T7934	amod	such,as
R6111	T7934	T7928	prep	as,effect
R6112	T7935	T7934	pobj	reduce,as
R6113	T7784	T7777	punct	.,be
R6114	T7936	T7935	dobj	inflammation,reduce
R6115	T7937	T7936	punct	",",inflammation
R6116	T7938	T7939	amod	behavioral,dysfunction
R6117	T7785	T7792	advmod	However,activated
R6118	T7939	T7936	conj	dysfunction,inflammation
R6119	T7940	T7939	punct	",",dysfunction
R6120	T7941	T7939	cc	and,dysfunction
R6121	T7942	T7943	amod	neuronal,damage
R6122	T7943	T7939	conj	damage,dysfunction
R6123	T7944	T7943	acl	produced,damage
R6124	T7786	T7792	punct	",",activated
R6125	T7945	T7944	agent	by,produced
R6126	T7946	T7947	compound	ICH,[
R6127	T7947	T7945	pobj	[,by
R6128	T7787	T7792	advmod	how,activated
R6129	T7948	T7949	nummod	17,]
R6130	T7949	T7947	appos	],[
R6131	T7950	T7923	punct	.,shown
R6132	T7788	T7790	det	the,responses
R6133	T7951	T7952	det	The,knowledge
R6134	T7952	T7961	nsubj	knowledge,subjected
R6135	T7953	T7952	prep	about,knowledge
R6136	T7789	T7790	amod	inflammatory,responses
R6137	T7954	T7957	advmod	how,activated
R6138	T7955	T7957	nsubjpass	NFκB,activated
R6139	T7956	T7957	auxpass	is,activated
R6140	T7957	T7953	pcomp	activated,about
R6141	T7790	T7792	nsubjpass	responses,activated
R6142	T7958	T7957	prep	in,activated
R6143	T7959	T7960	det	the,brain
R6144	T7960	T7958	pobj	brain,in
R6145	T7791	T7792	auxpass	is,activated
R6146	T7792	T7792	ROOT	activated,activated
R6147	T7793	T7792	cc	and,activated
R6148	T7794	T7792	conj	regulated,activated
R6149	T7795	T7794	prep	in,regulated
R6150	T7961	T7964	csubj	subjected,is
R6151	T7962	T7961	prep	to,subjected
R6152	T7963	T7962	pobj	ICH,to
R6153	T7796	T7798	det	the,tissue
R6154	T7964	T7964	ROOT	is,is
R6155	T7965	T7964	acomp	critical,is
R6156	T7797	T7798	compound	brain,tissue
R6157	T7966	T7965	prep	for,critical
R6158	T7967	T7966	pcomp	seeking,for
R6159	T7968	T7971	det	a,method
R6160	T7969	T7971	amod	new,method
R6161	T7798	T7795	pobj	tissue,in
R6162	T7970	T7971	amod	neuroprotective,method
R6163	T7971	T7967	dobj	method,seeking
R6164	T7972	T7971	prep	for,method
R6165	T7799	T7801	mark	after,is
R6166	T7973	T7972	pobj	ICH,for
R6167	T7974	T7964	punct	.,is
R6168	T7975	T7976	amod	Toll-like,receptors
R6169	T7800	T7801	nsubj	ICH,is
R6170	T7976	T7980	nsubj	receptors,are
R6171	T7977	T7976	punct	(,receptors
R6172	T7978	T7976	appos	TLRs,receptors
R6173	T7979	T7976	punct	),receptors
R6174	T7980	T7980	ROOT	are,are
R6175	T7801	T7794	advcl	is,regulated
R6176	T7802	T7801	acomp	unclear,is
R6177	T7981	T7982	det	a,family
R6178	T7982	T7980	attr	family,are
R6179	T7803	T7792	punct	.,activated
R6180	T7983	T7982	prep	of,family
R6181	T7984	T7986	nmod	signal,molecules
R6182	T7985	T7986	compound	transduction,molecules
R6183	T7804	T7805	amod	Transcription,factor
R6184	T7986	T7983	pobj	molecules,of
R6185	T7987	T7982	cc	and,family
R6186	T7988	T7980	conj	play,are
R6187	T7805	T7811	nsubj	factor,is
R6188	T7989	T7991	det	a,role
R6189	T7806	T7807	amod	nuclear,factor-kappa-B
R6190	T7990	T7991	amod	critical,role
R6191	T7991	T7988	dobj	role,play
R6192	T7992	T7988	prep	in,play
R6193	T7993	T7994	det	the,induction
R6194	T8058	T8049	conj	],diseases
R6195	T7994	T7992	pobj	induction,in
R6196	T7995	T7994	prep	of,induction
R6197	T7996	T7999	amod	innate,immunity
R6198	T7997	T7996	cc	and,innate
R6199	T8059	T8029	punct	.,reported
R6200	T7998	T7996	conj	adaptive,innate
R6201	T7999	T8000	compound	immunity,[
R6202	T8000	T7995	pobj	[,of
R6203	T8001	T8000	nummod	4,[
R6204	T8002	T7994	appos	],induction
R6205	T8003	T7980	punct	.,are
R6206	T8060	T8063	mark	Although,indicated
R6207	T8004	T8004	ROOT	TLR-mediated,TLR-mediated
R6208	T8005	T8004	advcl	signaling,TLR-mediated
R6209	T8006	T8008	nsubj	pathways,stimulate
R6210	T8061	T8062	amod	previous,reports
R6211	T8007	T8008	advmod	mainly,stimulate
R6212	T8008	T8005	ccomp	stimulate,signaling
R6213	T8009	T8010	det	the,activation
R6214	T8062	T8063	nsubj	reports,indicated
R6215	T8010	T8008	dobj	activation,stimulate
R6216	T8011	T8010	prep	of,activation
R6217	T8012	T8013	compound	NFκB,[
R6218	T8063	T8096	advcl	indicated,directed
R6219	T8013	T8011	pobj	[,of
R6220	T8014	T8016	quantmod	12,13
R6221	T8015	T8016	punct	",",13
R6222	T8016	T8017	nummod	13,]
R6223	T8017	T8013	appos	],[
R6224	T8018	T8005	punct	.,signaling
R6225	T8064	T8070	mark	that,attributed
R6226	T8019	T8025	npadvmod	TLR4,recognized
R6227	T8020	T8019	punct	",",TLR4
R6228	T8065	T8066	det	the,activation
R6229	T8066	T8070	nsubjpass	activation,attributed
R6230	T8021	T8024	det	the,TLR
R6231	T8022	T8024	amod	first,TLR
R6232	T8067	T8066	prep	of,activation
R6233	T8023	T8024	amod	mammalian,TLR
R6234	T8024	T8025	nsubj	TLR,recognized
R6235	T8025	T8029	csubjpass	recognized,reported
R6236	T8068	T8067	pobj	NFκB,of
R6237	T8026	T8025	punct	",",recognized
R6238	T8027	T8029	aux	has,reported
R6239	T8028	T8029	auxpass	been,reported
R6240	T8029	T8029	ROOT	reported,reported
R6241	T8030	T8032	aux	to,involved
R6242	T8069	T8070	auxpass	was,attributed
R6243	T8031	T8032	auxpass	be,involved
R6244	T8032	T8029	xcomp	involved,reported
R6245	T8033	T8032	prep	in,involved
R6246	T8070	T8063	ccomp	attributed,indicated
R6247	T8034	T8036	amod	several,nervous
R6248	T8035	T8036	amod	central,nervous
R6249	T8036	T8033	pobj	nervous,in
R6250	T8071	T8070	prep	to,attributed
R6251	T8037	T8036	punct	(,nervous
R6252	T8038	T8040	nmod	CNS,system
R6253	T8039	T8040	punct	),system
R6254	T8040	T8041	compound	system,diseases
R6255	T8072	T8074	det	the,stress
R6256	T8041	T8036	appos	diseases,nervous
R6257	T8042	T8041	punct	",",diseases
R6258	T8043	T8044	amod	such,as
R6259	T8073	T8074	amod	oxidative,stress
R6260	T8044	T8041	prep	as,diseases
R6261	T8045	T8049	amod	inflammatory,diseases
R6262	T8046	T8045	cc	or,inflammatory
R6263	T8047	T8045	conj	autoimmune,inflammatory
R6264	T8074	T8071	pobj	stress,to
R6265	T8048	T8045	conj	CNS,inflammatory
R6266	T8049	T8044	pobj	diseases,as
R6267	T8075	T8074	cc	or,stress
R6268	T8050	T8049	cc	and,diseases
R6269	T8051	T8058	amod	cerebral,]
R6270	T8052	T8058	dep	ischemic,]
R6271	T8053	T8054	compound	injury,[
R6272	T8054	T8052	appos	[,ischemic
R6273	T8055	T8054	nummod	7,[
R6274	T8056	T8058	punct	",",]
R6275	T8076	T8078	compound	glutamate,activation
R6276	T8057	T8058	nummod	8,]
R6277	T8077	T8078	compound	receptor,activation
R6278	T8078	T8074	conj	activation,stress
R6279	T8079	T8078	acl	induced,activation
R6280	T8080	T8079	agent	by,induced
R6281	T8155	T8156	det	These,changes
R6282	T8156	T8157	nsubj	changes,started
R6283	T8081	T8083	amod	red,cells
R6284	T8157	T8157	ROOT	started,started
R6285	T8158	T8159	advmod	as,early
R6286	T8159	T8157	advmod	early,started
R6287	T8082	T8083	compound	blood,cells
R6288	T8160	T8159	prep	as,early
R6289	T8161	T8162	nummod	6,hours
R6290	T8083	T8080	pobj	cells,by
R6291	T8162	T8163	npadvmod	hours,after
R6292	T8163	T8160	prep	after,as
R6293	T8164	T8166	det	the,insult
R6294	T8084	T8083	cc	and/or,cells
R6295	T8165	T8166	compound	ICH,insult
R6296	T8166	T8163	pobj	insult,after
R6297	T8167	T8157	cc	and,started
R6298	T8085	T8086	compound	plasma,constituents
R6299	T8168	T8157	conj	maintained,started
R6300	T8169	T8168	prep	at,maintained
R6301	T8170	T8172	det	a,level
R6302	T8171	T8172	amod	high,level
R6303	T8086	T8083	conj	constituents,cells
R6304	T8172	T8169	pobj	level,at
R6305	T8173	T8168	prep	for,maintained
R6306	T8087	T8089	nmod	[,]
R6307	T8174	T8175	nummod	7,days
R6308	T8175	T8173	pobj	days,for
R6309	T8176	T8168	advmod	afterward,maintained
R6310	T8088	T8089	nummod	17,]
R6311	T8177	T8157	punct	.,started
R6312	T8178	T8180	det	The,protein
R6313	T8179	T8180	nummod	TLR4,protein
R6314	T8089	T8083	appos	],cells
R6315	T8180	T8188	nsubjpass	protein,distributed
R6316	T8181	T8180	punct	",",protein
R6317	T8182	T8180	acl	detected,protein
R6318	T8090	T8096	punct	",",directed
R6319	T8183	T8182	agent	by,detected
R6320	T8184	T8183	pobj	immunohistochemistry,by
R6321	T8185	T8180	punct	",",protein
R6322	T8186	T8188	auxpass	was,distributed
R6323	T8187	T8188	advmod	consistently,distributed
R6324	T8188	T8188	ROOT	distributed,distributed
R6325	T8091	T8092	advmod	very,few
R6326	T8189	T8188	prep	in,distributed
R6327	T8190	T8191	amod	peri-hemorrhage,areas
R6328	T8191	T8189	pobj	areas,in
R6329	T8092	T8093	amod	few,studies
R6330	T8192	T8188	punct	",",distributed
R6331	T8193	T8194	det	the,hippocampus
R6332	T8093	T8096	nsubjpass	studies,directed
R6333	T8194	T8188	dep	hippocampus,distributed
R6334	T8195	T8194	punct	",",hippocampus
R6335	T8196	T8194	conj	cortex,hippocampus
R6336	T8197	T8196	punct	",",cortex
R6337	T8094	T8096	aux	have,directed
R6338	T8198	T8199	amod	thalamic,nuclei
R6339	T8199	T8196	conj	nuclei,cortex
R6340	T8200	T8199	punct	",",nuclei
R6341	T8095	T8096	auxpass	been,directed
R6342	T8201	T8199	cc	and,nuclei
R6343	T8202	T8205	det	some,tracts
R6344	T8096	T8096	ROOT	directed,directed
R6345	T8203	T8205	amod	white,tracts
R6346	T8204	T8205	compound	matter,tracts
R6347	T8205	T8199	conj	tracts,nuclei
R6348	T8097	T8098	aux	to,investigate
R6349	T8206	T8188	punct	.,distributed
R6350	T8207	T8208	det	These,data
R6351	T8208	T8209	nsubj	data,indicated
R6352	T8098	T8096	xcomp	investigate,directed
R6353	T8209	T8209	ROOT	indicated,indicated
R6354	T8210	T8217	mark	that,related
R6355	T8211	T8212	amod	increased,expression
R6356	T8212	T8217	nsubjpass	expression,related
R6357	T8099	T8100	det	the,role
R6358	T8213	T8212	prep	of,expression
R6359	T8214	T8213	pobj	TLR4,of
R6360	T8215	T8217	aux	may,related
R6361	T8100	T8098	dobj	role,investigate
R6362	T8216	T8217	auxpass	be,related
R6363	T8217	T8209	ccomp	related,indicated
R6364	T8101	T8100	cc	and,role
R6365	T8218	T8217	prep	to,related
R6366	T8102	T8103	det	the,relationship
R6367	T8219	T8220	det	the,triggering
R6368	T8220	T8218	pobj	triggering,to
R6369	T8221	T8220	prep	of,triggering
R6370	T8222	T8224	det	the,responses
R6371	T8223	T8224	amod	inflammatory,responses
R6372	T8224	T8221	pobj	responses,of
R6373	T8225	T8224	prep	in,responses
R6374	T8103	T8100	conj	relationship,role
R6375	T8226	T8228	det	the,tissue
R6376	T8227	T8228	compound	brain,tissue
R6377	T8104	T8103	prep	between,relationship
R6378	T8228	T8225	pobj	tissue,in
R6379	T8229	T8217	prep	after,related
R6380	T8230	T8229	pobj	ICH,after
R6381	T8105	T8106	compound	TLR4-mediated,NFκB
R6382	T8231	T8209	punct	.,indicated
R6383	T8232	T8233	amod	Recent,studies
R6384	T8233	T8234	nsubj	studies,demonstrated
R6385	T8106	T8104	pobj	NFκB,between
R6386	T8234	T8234	ROOT	demonstrated,demonstrated
R6387	T8235	T8237	mark	that,initiates
R6388	T8236	T8237	nsubj	ICH,initiates
R6389	T8237	T8234	ccomp	initiates,demonstrated
R6390	T8107	T8104	pobj	signaling,between
R6391	T8238	T8239	amod	inflammatory,responses
R6392	T8239	T8237	dobj	responses,initiates
R6393	T8240	T8239	punct	",",responses
R6394	T8108	T8107	cc	and,signaling
R6395	T8241	T8243	nsubjpass	which,associated
R6396	T8242	T8243	auxpass	are,associated
R6397	T8243	T8239	relcl	associated,responses
R6398	T8109	T8107	conj	ICH,signaling
R6399	T8244	T8243	prep	with,associated
R6400	T8245	T8246	amod	secondary,growth
R6401	T8246	T8244	pobj	growth,with
R6402	T8110	T8096	punct	.,directed
R6403	T8247	T8246	prep	of,growth
R6404	T8248	T8247	pobj	hemorrhage,of
R6405	T8111	T8117	prep	In,established
R6406	T8249	T8248	cc	and,hemorrhage
R6407	T8250	T8251	compound	cell,death
R6408	T8251	T8248	conj	death,hemorrhage
R6409	T8112	T8114	det	the,study
R6410	T8113	T8114	amod	present,study
R6411	T8114	T8111	pobj	study,In
R6412	T8252	T8254	nmod	[,]
R6413	T8253	T8254	nummod	18,]
R6414	T8115	T8117	punct	",",established
R6415	T8254	T8246	appos	],growth
R6416	T8255	T8234	punct	.,demonstrated
R6417	T8116	T8117	nsubj	we,established
R6418	T8256	T8259	nsubjpass	It,believed
R6419	T8257	T8259	auxpass	is,believed
R6420	T8258	T8259	advmod	now,believed
R6421	T8117	T8117	ROOT	established,established
R6422	T8259	T8259	ROOT	believed,believed
R6423	T8260	T8263	mark	that,activates
R6424	T8261	T8262	amod	TLR4-mediated-NFκB,pathway
R6425	T8262	T8263	nsubj	pathway,activates
R6426	T8263	T8259	ccomp	activates,believed
R6427	T8264	T8263	cc	and,activates
R6428	T8265	T8263	conj	regulates,activates
R6429	T8118	T8120	det	the,model
R6430	T8266	T8269	amod	immunological,responses
R6431	T8267	T8266	cc	and,immunological
R6432	T8268	T8266	conj	inflammatory,immunological
R6433	T8269	T8265	dobj	responses,regulates
R6434	T8119	T8120	compound	rat,model
R6435	T8270	T8259	punct	.,believed
R6436	T8271	T8272	aux	To,investigate
R6437	T8120	T8117	dobj	model,established
R6438	T8272	T8292	advcl	investigate,evaluated
R6439	T8273	T8274	det	the,mechanisms
R6440	T8274	T8272	dobj	mechanisms,investigate
R6441	T8275	T8274	acl	underlying,mechanisms
R6442	T8121	T8120	prep	of,model
R6443	T8276	T8279	det	the,responses
R6444	T8122	T8123	amod	experimental,ICH
R6445	T8277	T8279	amod	increased,responses
R6446	T8278	T8279	amod	inflammatory,responses
R6447	T8279	T8275	dobj	responses,underlying
R6448	T8280	T8279	prep	in,responses
R6449	T8281	T8282	det	the,brain
R6450	T8123	T8121	pobj	ICH,of
R6451	T8282	T8280	pobj	brain,in
R6452	T8283	T8292	mark	after,evaluated
R6453	T8284	T8292	nsubj	ICH,evaluated
R6454	T8124	T8117	cc	and,established
R6455	T8285	T8292	punct	",",evaluated
R6456	T8286	T8292	prep	in,evaluated
R6457	T8287	T8289	det	the,study
R6458	T8125	T8117	conj	detected,established
R6459	T8288	T8289	amod	present,study
R6460	T8289	T8286	pobj	study,in
R6461	T8290	T8292	punct	",",evaluated
R6462	T8126	T8128	det	the,mRNA
R6463	T8291	T8292	nsubj	we,evaluated
R6464	T8292	T8292	ROOT	evaluated,evaluated
R6465	T8293	T8294	det	the,activation
R6466	T8294	T8292	dobj	activation,evaluated
R6467	T8127	T8128	nummod	TLR4,mRNA
R6468	T8295	T8294	prep	of,activation
R6469	T8296	T8297	compound	TLR4-mediated,NFκB
R6470	T8128	T8125	dobj	mRNA,detected
R6471	T8129	T8128	cc	and,mRNA
R6472	T8297	T8295	pobj	NFκB,of
R6473	T8298	T8294	acl	signaling,activation
R6474	T8299	T8292	prep	by,evaluated
R6475	T8300	T8299	pcomp	detecting,by
R6476	T8301	T8302	det	the,p-IκB
R6477	T8302	T8300	dobj	p-IκB,detecting
R6478	T8130	T8128	conj	protein,mRNA
R6479	T8303	T8302	cc	and,p-IκB
R6480	T8304	T8305	det	the,activity
R6481	T8305	T8302	conj	activity,p-IκB
R6482	T8131	T8117	punct	.,established
R6483	T8306	T8305	prep	of,activity
R6484	T8307	T8306	pobj	NFκB,of
R6485	T8132	T8133	poss	Our,data
R6486	T8308	T8305	prep	in,activity
R6487	T8309	T8310	amod	hemorrhagic,brains
R6488	T8310	T8308	pobj	brains,in
R6489	T8133	T8134	nsubj	data,showed
R6490	T8311	T8292	punct	.,evaluated
R6491	T8312	T8313	nsubj	NFκB,is
R6492	T8134	T8134	ROOT	showed,showed
R6493	T8313	T8313	ROOT	is,is
R6494	T8314	T8317	det	an,factor
R6495	T8315	T8317	amod	important,factor
R6496	T8135	T8136	det	that,transcription
R6497	T8316	T8317	compound	transcription,factor
R6498	T8317	T8313	attr	factor,is
R6499	T8136	T8134	dobj	transcription,showed
R6500	T8318	T8317	amod	downstream,factor
R6501	T8319	T8318	prep	in,downstream
R6502	T8320	T8323	det	the,pathway
R6503	T8321	T8323	amod	TLR4-mediated,pathway
R6504	T8137	T8136	prep	of,transcription
R6505	T8322	T8323	amod	signaling,pathway
R6506	T8323	T8319	pobj	pathway,in
R6507	T8138	T8137	pobj	TLR4,of
R6508	T8324	T8313	punct	.,is
R6509	T8325	T8328	nsubj	Activation,stimulates
R6510	T8326	T8325	prep	of,Activation
R6511	T8139	T8141	advmod	as,as
R6512	T8327	T8328	nummod	TLR4,stimulates
R6513	T8328	T8328	ROOT	stimulates,stimulates
R6514	T8329	T8330	compound	IκBα,phosphorylation
R6515	T8330	T8328	dobj	phosphorylation,stimulates
R6516	T8140	T8141	advmod	well,as
R6517	T8331	T8330	cc	and,phosphorylation
R6518	T8332	T8330	conj	degradation,phosphorylation
R6519	T8333	T8330	punct	",",phosphorylation
R6520	T8141	T8136	cc	as,transcription
R6521	T8334	T8328	advcl	resulting,stimulates
R6522	T8335	T8334	prep	in,resulting
R6523	T8336	T8337	amod	nuclear,translocation
R6524	T8337	T8335	pobj	translocation,in
R6525	T8338	T8337	prep	of,translocation
R6526	T8339	T8338	pobj	NFκB,of
R6527	T8340	T8339	punct	",",NFκB
R6528	T8142	T8143	det	the,expression
R6529	T8341	T8342	nsubj	which,initiates
R6530	T8342	T8339	relcl	initiates,NFκB
R6531	T8343	T8342	dobj	transcription,initiates
R6532	T8143	T8136	conj	expression,transcription
R6533	T8344	T8343	prep	of,transcription
R6534	T8345	T8344	pobj	genes,of
R6535	T8346	T8345	acl	associated,genes
R6536	T8144	T8143	prep	of,expression
R6537	T8347	T8346	prep	with,associated
R6538	T8348	T8350	amod	innate,responses
R6539	T8145	T8146	nummod	TLR4,protein
R6540	T8146	T8144	pobj	protein,of
R6541	T8147	T8150	mark	after,elevated
R6542	T8148	T8150	nsubj	ICH,elevated
R6543	T8349	T8350	amod	immune,responses
R6544	T8350	T8347	pobj	responses,with
R6545	T8149	T8150	advmod	significantly,elevated
R6546	T8351	T8350	cc	and,responses
R6547	T8352	T8353	compound	inflammation,[
R6548	T8353	T8350	conj	[,responses
R6549	T8150	T8136	acl	elevated,transcription
R6550	T8354	T8353	nummod	5,[
R6551	T8355	T8356	punct	",",6
R6552	T8151	T8150	prep	in,elevated
R6553	T8356	T8357	nummod	6,]
R6554	T8357	T8353	appos	],[
R6555	T8358	T8328	punct	.,stimulates
R6556	T8152	T8153	compound	brain,tissue
R6557	T8359	T8360	nsubj	We,observed
R6558	T8360	T8360	ROOT	observed,observed
R6559	T8361	T8375	mark	that,increased
R6560	T8362	T8363	det	the,levels
R6561	T8153	T8151	pobj	tissue,in
R6562	T8363	T8375	nsubjpass	levels,increased
R6563	T8364	T8363	prep	of,levels
R6564	T8365	T8364	pobj	phosphorylation,of
R6565	T8154	T8134	punct	.,showed
R6566	T8366	T8365	prep	of,phosphorylation
R6567	T8367	T8366	pobj	IκB,of
R6568	T8368	T8365	cc	and,phosphorylation
R6569	T8446	T8447	amod	microbial,components
R6570	T8369	T8370	det	the,activity
R6571	T8370	T8365	conj	activity,phosphorylation
R6572	T8371	T8370	prep	of,activity
R6573	T8372	T8371	pobj	NFκB,of
R6574	T8373	T8375	auxpass	were,increased
R6575	T8374	T8375	advmod	significantly,increased
R6576	T8375	T8360	ccomp	increased,observed
R6577	T8447	T8445	pobj	components,of
R6578	T8448	T8456	nsubj	[,recognize
R6579	T8376	T8375	prep	in,increased
R6580	T8377	T8378	compound	brain,tissue
R6581	T8378	T8376	pobj	tissue,in
R6582	T8449	T8448	nummod	19,[
R6583	T8379	T8375	prep	after,increased
R6584	T8380	T8379	pobj	ICH,after
R6585	T8381	T8360	punct	.,observed
R6586	T8450	T8448	punct	",",[
R6587	T8382	T8384	det	The,profile
R6588	T8383	T8384	amod	temporal,profile
R6589	T8451	T8452	nummod	20,]
R6590	T8384	T8395	nsubj	profile,was
R6591	T8385	T8384	prep	of,profile
R6592	T8386	T8387	det	the,expression
R6593	T8452	T8448	appos	],[
R6594	T8453	T8452	cc	and,]
R6595	T8454	T8456	aux	can,recognize
R6596	T8387	T8385	pobj	expression,of
R6597	T8455	T8456	advmod	also,recognize
R6598	T8388	T8387	prep	of,expression
R6599	T8389	T8388	pobj	p-IκB,of
R6600	T8390	T8387	cc	and,expression
R6601	T8391	T8392	det	the,activation
R6602	T8392	T8395	nsubj	activation,was
R6603	T8456	T8456	ROOT	recognize,recognize
R6604	T8393	T8392	prep	of,activation
R6605	T8394	T8393	pobj	NFκB,of
R6606	T8395	T8395	ROOT	was,was
R6607	T8396	T8395	acomp	similar,was
R6608	T8457	T8458	amod	endogenous,molecules
R6609	T8397	T8396	prep	to,similar
R6610	T8398	T8397	pobj	that,to
R6611	T8399	T8398	prep	of,that
R6612	T8458	T8456	dobj	molecules,recognize
R6613	T8400	T8401	det	the,expression
R6614	T8401	T8399	pobj	expression,of
R6615	T8402	T8401	prep	of,expression
R6616	T8459	T8460	amod	such,as
R6617	T8403	T8402	pobj	TLR4,of
R6618	T8404	T8395	punct	.,was
R6619	T8405	T8406	poss	Our,data
R6620	T8460	T8458	prep	as,molecules
R6621	T8406	T8407	nsubj	data,suggest
R6622	T8407	T8407	ROOT	suggest,suggest
R6623	T8408	T8410	mark	that,stimulates
R6624	T8409	T8410	nsubj	ICH,stimulates
R6625	T8410	T8407	ccomp	stimulates,suggest
R6626	T8411	T8410	dobj	activation,stimulates
R6627	T8412	T8411	prep	of,activation
R6628	T8461	T8463	det	the,products
R6629	T8413	T8417	det	the,pathway
R6630	T8414	T8415	nummod	TLR4/NF,κB
R6631	T8415	T8417	nmod	κB,pathway
R6632	T8462	T8463	compound	degradation,products
R6633	T8416	T8417	amod	signaling,pathway
R6634	T8417	T8412	pobj	pathway,of
R6635	T8418	T8417	punct	",",pathway
R6636	T8419	T8420	nsubj	which,is
R6637	T8463	T8460	pobj	products,as
R6638	T8420	T8417	relcl	is,pathway
R6639	T8421	T8420	acomp	consistent,is
R6640	T8422	T8421	prep	with,consistent
R6641	T8464	T8463	prep	of,products
R6642	T8423	T8424	amod	previous,reports
R6643	T8424	T8422	pobj	reports,with
R6644	T8425	T8430	mark	that,regulated
R6645	T8426	T8430	nsubjpass	activation,regulated
R6646	T8465	T8464	pobj	macromolecules,of
R6647	T8427	T8426	prep	of,activation
R6648	T8428	T8427	pobj	NFκB,of
R6649	T8429	T8430	auxpass	is,regulated
R6650	T8466	T8463	punct	",",products
R6651	T8430	T8424	acl	regulated,reports
R6652	T8431	T8430	prep	through,regulated
R6653	T8432	T8435	det	the,pathway
R6654	T8467	T8463	conj	products,products
R6655	T8433	T8435	amod	TLR4-mediated,pathway
R6656	T8434	T8435	amod	signaling,pathway
R6657	T8435	T8431	pobj	pathway,through
R6658	T8468	T8463	prep	of,products
R6659	T8436	T8407	punct	.,suggest
R6660	T8437	T8438	nsubj	TLR4,plays
R6661	T8469	T8470	amod	proteolytic,cascades
R6662	T8438	T8438	ROOT	plays,plays
R6663	T8439	T8441	det	an,role
R6664	T8440	T8441	amod	important,role
R6665	T8441	T8438	dobj	role,plays
R6666	T8470	T8468	pobj	cascades,of
R6667	T8442	T8441	prep	in,role
R6668	T8443	T8444	det	the,recognition
R6669	T8444	T8442	pobj	recognition,in
R6670	T8471	T8470	punct	",",cascades
R6671	T8445	T8444	prep	of,recognition
R6672	T8472	T8473	amod	intracellular,components
R6673	T8473	T8463	conj	components,products
R6674	T8474	T8473	prep	of,components
R6675	T8543	T8544	compound	blood,cells
R6676	T8475	T8476	amod	ruptured,cells
R6677	T8544	T8542	pobj	cells,from
R6678	T8545	T8544	cc	and,cells
R6679	T8476	T8474	pobj	cells,of
R6680	T8546	T8544	conj	constituents,cells
R6681	T8547	T8544	prep	of,cells
R6682	T8548	T8549	compound	plasma,server
R6683	T8477	T8473	punct	",",components
R6684	T8549	T8547	pobj	server,of
R6685	T8550	T8541	prep	as,came
R6686	T8551	T8553	amod	endogenous,ligands
R6687	T8478	T8473	cc	and,components
R6688	T8552	T8553	nummod	TLR4,ligands
R6689	T8553	T8550	pobj	ligands,as
R6690	T8554	T8541	punct	",",came
R6691	T8479	T8473	conj	products,components
R6692	T8555	T8532	conj	activate,speculated
R6693	T8556	T8557	compound	TLR4-mediated,NFκB
R6694	T8557	T8558	nsubj	NFκB,signaling
R6695	T8480	T8479	prep	of,products
R6696	T8558	T8555	ccomp	signaling,activate
R6697	T8559	T8558	punct	",",signaling
R6698	T8481	T8480	pobj	genes,of
R6699	T8560	T8555	cc	and,activate
R6700	T8561	T8555	conj	initiate,activate
R6701	T8562	T8564	det	the,responses
R6702	T8482	T8484	nsubjpass	that,activated
R6703	T8563	T8564	amod	inflammatory,responses
R6704	T8564	T8561	dobj	responses,initiate
R6705	T8565	T8564	prep	in,responses
R6706	T8483	T8484	auxpass	are,activated
R6707	T8566	T8567	compound	IHC,brain
R6708	T8567	T8565	pobj	brain,in
R6709	T8568	T8532	punct	.,speculated
R6710	T8484	T8463	relcl	activated,products
R6711	T8569	T8583	advmod	However,determined
R6712	T8570	T8583	punct	",",determined
R6713	T8485	T8484	agent	by,activated
R6714	T8571	T8574	det	the,ligands
R6715	T8572	T8574	amod	specific,ligands
R6716	T8573	T8574	compound	endogenous,ligands
R6717	T8574	T8583	nsubjpass	ligands,determined
R6718	T8486	T8485	pobj	inflammation,by
R6719	T8575	T8574	prep	for,ligands
R6720	T8576	T8575	pobj	TLR4,for
R6721	T8577	T8576	prep	in,TLR4
R6722	T8487	T8456	punct	.,recognize
R6723	T8488	T8498	prep	For,enzymes
R6724	T8489	T8488	pobj	instance,For
R6725	T8578	T8579	amod	hemorrhagic,brain
R6726	T8579	T8577	pobj	brain,in
R6727	T8580	T8583	aux	have,determined
R6728	T8581	T8583	neg	not,determined
R6729	T8582	T8583	auxpass	been,determined
R6730	T8490	T8498	punct	",",enzymes
R6731	T8583	T8583	ROOT	determined,determined
R6732	T8584	T8583	cc	and,determined
R6733	T8585	T8583	conj	need,determined
R6734	T8491	T8498	nsubj	HSP70,enzymes
R6735	T8586	T8588	aux	to,identified
R6736	T8587	T8588	auxpass	be,identified
R6737	T8588	T8585	xcomp	identified,need
R6738	T8492	T8491	punct	",",HSP70
R6739	T8589	T8588	prep	through,identified
R6740	T8590	T8591	amod	further,research
R6741	T8591	T8589	pobj	research,through
R6742	T8592	T8583	punct	.,determined
R6743	T8493	T8491	conj	HSP32,HSP70
R6744	T8593	T8599	prep	In,demonstrated
R6745	T8594	T8593	pobj	conclusion,In
R6746	T8595	T8599	punct	",",demonstrated
R6747	T8494	T8493	punct	",",HSP32
R6748	T8596	T8598	det	the,study
R6749	T8597	T8598	amod	present,study
R6750	T8495	T8493	conj	HSP27,HSP32
R6751	T8598	T8599	nsubj	study,demonstrated
R6752	T8599	T8599	ROOT	demonstrated,demonstrated
R6753	T8600	T8602	det	the,profile
R6754	T8601	T8602	amod	temporal,profile
R6755	T8496	T8495	punct	",",HSP27
R6756	T8602	T8599	dobj	profile,demonstrated
R6757	T8603	T8602	prep	of,profile
R6758	T8604	T8605	det	the,activation
R6759	T8497	T8495	cc	and,HSP27
R6760	T8605	T8603	pobj	activation,of
R6761	T8606	T8605	prep	of,activation
R6762	T8498	T8498	ROOT	enzymes,enzymes
R6763	T8607	T8608	compound	TLR4-mediated,NFκB
R6764	T8608	T8606	pobj	NFκB,of
R6765	T8609	T8602	acl	signaling,profile
R6766	T8610	T8609	prep	in,signaling
R6767	T8499	T8498	acl	involved,enzymes
R6768	T8611	T8612	compound	brain,tissue
R6769	T8612	T8610	pobj	tissue,in
R6770	T8500	T8499	prep	in,involved
R6771	T8501	T8502	amod	oxidative,stress
R6772	T8613	T8612	prep	in,tissue
R6773	T8502	T8500	pobj	stress,in
R6774	T8614	T8616	det	a,model
R6775	T8615	T8616	compound	rat,model
R6776	T8616	T8613	pobj	model,in
R6777	T8617	T8616	prep	of,model
R6778	T8618	T8619	amod	experimental,ICH
R6779	T8619	T8617	pobj	ICH,of
R6780	T8503	T8504	auxpass	are,found
R6781	T8620	T8619	punct	",",ICH
R6782	T8621	T8622	nsubj	which,suggests
R6783	T8504	T8498	conj	found,enzymes
R6784	T8622	T8602	relcl	suggests,profile
R6785	T8623	T8627	mark	that,participates
R6786	T8624	T8625	compound	TLR4-mediated,NFκB
R6787	T8625	T8627	nsubj	NFκB,participates
R6788	T8505	T8507	aux	to,upregulated
R6789	T8626	T8625	acl	signaling,NFκB
R6790	T8627	T8622	ccomp	participates,suggests
R6791	T8506	T8507	auxpass	be,upregulated
R6792	T8628	T8627	prep	in,participates
R6793	T8629	T8630	det	the,pathogenesis
R6794	T8630	T8628	pobj	pathogenesis,in
R6795	T8631	T8630	prep	of,pathogenesis
R6796	T8507	T8504	xcomp	upregulated,found
R6797	T8632	T8631	pobj	ICH,of
R6798	T8633	T8632	punct	",",ICH
R6799	T8634	T8636	nsubj	which,be
R6800	T8508	T8507	prep	in,upregulated
R6801	T8635	T8636	aux	may,be
R6802	T8636	T8630	relcl	be,pathogenesis
R6803	T8637	T8639	det	a,target
R6804	T8509	T8510	det	the,brain
R6805	T8638	T8639	amod	therapeutic,target
R6806	T8639	T8636	attr	target,be
R6807	T8510	T8508	pobj	brain,in
R6808	T8511	T8507	prep	after,upregulated
R6809	T8640	T8639	prep	for,target
R6810	T8512	T8511	pobj	ICH,after
R6811	T8641	T8642	det	the,prevention
R6812	T8642	T8640	pobj	prevention,for
R6813	T8643	T8642	prep	of,prevention
R6814	T8513	T8512	punct	",",ICH
R6815	T8644	T8646	amod	ICH-induced,damage
R6816	T8645	T8646	compound	brain,damage
R6817	T8646	T8643	pobj	damage,of
R6818	T8514	T8517	nsubjpass	which,produced
R6819	T8647	T8599	punct	.,demonstrated
R6820	T8515	T8517	aux	may,produced
R6821	T8516	T8517	auxpass	be,produced
R6822	T8517	T8512	relcl	produced,ICH
R6823	T8518	T8517	agent	by,produced
R6824	T8519	T8521	amod	injured,cells
R6825	T8520	T8521	amod	neuronal,cells
R6826	T8521	T8518	pobj	cells,by
R6827	T8522	T8521	cc	or,cells
R6828	T8523	T8524	compound	blood,cells
R6829	T8524	T8521	conj	cells,cells
R6830	T8525	T8527	nmod	[,]
R6831	T8526	T8527	nummod	21,]
R6832	T8527	T8521	appos	],cells
R6833	T8528	T8498	punct	.,enzymes
R6834	T8529	T8532	nsubjpass	It,speculated
R6835	T8530	T8532	aux	may,speculated
R6836	T8531	T8532	auxpass	be,speculated
R6837	T8532	T8532	ROOT	speculated,speculated
R6838	T8533	T8541	mark	that,came
R6839	T8534	T8535	det	these,molecules
R6840	T8535	T8541	nsubj	molecules,came
R6841	T8536	T8535	acl	produced,molecules
R6842	T8537	T8536	prep	in,produced
R6843	T8538	T8539	amod	damaged,brain
R6844	T8539	T8537	pobj	brain,in
R6845	T8540	T8536	cc	or,produced
R6848	T8541	T8532	ccomp	came,speculated
R6850	T8542	T8541	prep	from,came
R923	T1284	T1285	compound	Intracerebral,hemorrhage
R924	T1285	T1289	nsubj	hemorrhage,represents
R925	T1286	T1287	punct	(,ICH
R926	T1287	T1285	appos	ICH,hemorrhage
R927	T1288	T1285	punct	),hemorrhage
R928	T1289	T1289	ROOT	represents,represents
R929	T1290	T1291	nummod	10,%
R930	T1291	T1289	dobj	%,represents
R931	T1292	T1293	nummod	15,%
R932	T1293	T1289	npadvmod	%,represents
R933	T1294	T1293	prep	of,%
R934	T1295	T1296	det	all,strokes
R935	T1296	T1294	pobj	strokes,of
R936	T1297	T1289	cc	and,represents
R937	T1298	T1289	conj	occurs,represents
R938	T1299	T1298	prep	with,occurs
R939	T1300	T1301	amod	increasing,frequency
R940	T1301	T1299	pobj	frequency,with
R941	T1302	T1301	prep	as,frequency
R942	T1303	T1304	det	a,complication
R943	T1304	T1302	pobj	complication,as
R944	T1305	T1304	prep	of,complication
R945	T1306	T1308	det	the,treatment
R946	T1307	T1308	compound	thrombolytic,treatment
R947	T1308	T1305	pobj	treatment,of
R948	T1309	T1308	prep	of,treatment
R949	T1310	T1311	amod	ischemic,stroke
R950	T1311	T1309	pobj	stroke,of
R951	T1312	T1308	punct	",",treatment
R952	T1313	T1315	nsubjpass	which,associated
R953	T1314	T1315	auxpass	is,associated
R954	T1315	T1308	relcl	associated,treatment
R955	T1316	T1315	prep	with,associated
R956	T1317	T1318	amod	high,mortality
R957	T1318	T1316	pobj	mortality,with
R958	T1319	T1318	cc	and,mortality
R959	T1320	T1321	amod	severe,disability
R960	T1321	T1318	conj	disability,mortality
R961	T1322	T1318	prep	in,mortality
R962	T1323	T1322	pobj	survivors,in
R963	T1324	T1328	nmod	[,]
R964	T1325	T1324	nummod	1,[
R965	T1326	T1324	punct	",",[
R966	T1327	T1328	nummod	2,]
R967	T1328	T1298	npadvmod	],occurs
R968	T1329	T1289	punct	.,represents
R969	T1330	T1333	amod	Local,deformation
R970	T1331	T1332	compound	brain,tissue
R971	T1332	T1333	compound	tissue,deformation
R972	T1333	T1334	nsubj	deformation,induces
R973	T1334	T1334	ROOT	induces,induces
R974	T1335	T1337	amod	primary,damage
R975	T1336	T1337	compound	brain,damage
R976	T1337	T1334	dobj	damage,induces
R977	T1338	T1337	prep	after,damage
R978	T1339	T1338	pobj	ICH,after
R979	T1340	T1345	punct	;,excitotoxicity
R980	T1341	T1342	advmod	more,importantly
R981	T1342	T1345	advmod	importantly,excitotoxicity
R982	T1343	T1345	punct	",",excitotoxicity
R983	T1344	T1345	det	the,excitotoxicity
R984	T1345	T1334	dep	excitotoxicity,induces
R985	T1346	T1345	cc	and,excitotoxicity
R986	T1347	T1348	amod	inflammatory,responses
R987	T1348	T1345	conj	responses,excitotoxicity
R988	T1349	T1348	prep	in,responses
R989	T1350	T1352	det	the,tissue
R990	T1351	T1352	compound	brain,tissue
R991	T1352	T1349	pobj	tissue,in
R992	T1353	T1352	acl	induced,tissue
R993	T1354	T1353	agent	by,induced
R994	T1355	T1356	compound	ICH,result
R995	T1356	T1354	pobj	result,by
R996	T1357	T1353	prep	in,induced
R997	T1358	T1360	amod	further,damage
R998	T1359	T1360	compound	brain,damage
R999	T1360	T1357	pobj	damage,in

PMC:2817507 / 1381-18287 JSONTXT 26 Projects

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PMC:2817507 / 1381-18287 JSON TXT 26 Projects