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PMC:1942070 / 4530-13151 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2731 17-21 NN denotes Loss
T2732 22-24 IN denotes of
T2733 25-30 NNP denotes HSP27
T2734 31-46 NN denotes phosphorylation
T2735 47-49 IN denotes in
T2736 50-54 NNP denotes DT40
T2737 55-56 NNP denotes B
T2738 57-62 NNS denotes cells
T2739 63-70 VBG denotes lacking
T2740 71-81 NN denotes expression
T2741 82-84 IN denotes of
T2742 85-88 NNP denotes PKD
T2743 89-95 NN denotes family
T2744 96-103 VBZ denotes kinases
T2745 104-108 NNP denotes DT40
T2746 109-110 NNP denotes B
T2747 111-116 NNS denotes cells
T2748 117-124 VBP denotes express
T2749 125-128 CD denotes two
T2750 129-132 NNP denotes PKD
T2751 133-141 NNS denotes isoforms
T2752 141-142 , denotes ,
T2753 143-147 NNP denotes PKD1
T2754 148-151 CC denotes and
T2755 152-156 NNP denotes PKD3
T2756 156-157 , denotes ,
T2757 158-161 CC denotes and
T2758 162-164 IN denotes as
T2759 165-175 RB denotes previously
T2760 176-185 VBN denotes described
T2761 186-188 PRP denotes we
T2762 189-193 VBP denotes have
T2763 194-202 RB denotes recently
T2764 203-212 VBN denotes generated
T2765 213-217 NNP denotes DT40
T2766 218-219 NNP denotes B
T2767 220-224 NN denotes cell
T2768 225-230 NNS denotes lines
T2769 231-235 WDT denotes that
T2770 236-240 VBP denotes lack
T2771 241-251 NN denotes expression
T2772 252-254 IN denotes of
T2773 255-261 DT denotes either
T2774 262-266 CD denotes PKD1
T2775 267-269 CC denotes or
T2776 270-274 CD denotes PKD3
T2777 275-277 CC denotes or
T2778 278-282 DT denotes both
T2779 283-290 NNS denotes enzymes
T2780 291-292 VBP denotes [
T2781 292-293 CD denotes 1
T2782 293-294 NNP denotes ]
T2783 294-295 . denotes .
T2784 296-298 IN denotes In
T2785 299-309 VBG denotes generating
T2786 310-313 DT denotes the
T2787 314-320 JJ denotes double
T2788 321-329 NN denotes knockout
T2789 330-334 NN denotes cell
T2790 335-340 NNS denotes lines
T2791 341-343 PRP denotes we
T2792 344-352 VBD denotes targeted
T2793 353-356 DT denotes the
T2794 357-361 NNP denotes PKD1
T2795 362-366 NN denotes loci
T2796 367-369 IN denotes in
T2797 370-371 DT denotes a
T2798 372-376 NNP denotes PKD3
T2799 376-377 NNP denotes −
T2800 377-378 VBD denotes /
T2801 378-379 CD denotes −
T2802 380-384 NN denotes cell
T2803 385-389 NN denotes line
T2804 390-394 WDT denotes that
T2805 395-404 VBD denotes expressed
T2806 405-406 DT denotes a
T2807 407-416 NN denotes Flag-PKD3
T2808 417-426 NN denotes transgene
T2809 427-432 IN denotes under
T2810 433-436 DT denotes the
T2811 437-444 NN denotes control
T2812 445-447 IN denotes of
T2813 448-449 DT denotes a
T2814 450-471 JJ denotes doxycycline-inducible
T2815 472-480 NN denotes promoter
T2816 480-481 . denotes .
T2817 482-487 RB denotes Hence
T2818 487-488 , denotes ,
T2819 489-491 IN denotes in
T2820 492-495 DT denotes the
T2821 496-504 NN denotes presence
T2822 505-507 IN denotes of
T2823 508-519 NN denotes doxycycline
T2824 519-520 , denotes ,
T2825 521-530 NN denotes Flag-PKD3
T2826 531-541 NN denotes expression
T2827 542-544 IN denotes in
T2828 545-551 CD denotes PKD1/3
T2829 552-558 JJ denotes double
T2830 559-567 NN denotes knockout
T2831 568-573 NNS denotes cells
T2832 574-576 VBZ denotes is
T2833 577-587 JJ denotes comparable
T2834 588-590 TO denotes to
T2835 591-601 JJ denotes endogenous
T2836 602-606 JJ denotes PKD3
T2837 607-614 NN denotes present
T2838 615-617 IN denotes in
T2839 618-627 JJ denotes wild-type
T2840 628-632 NNP denotes DT40
T2841 633-638 NNS denotes cells
T2842 639-642 CC denotes and
T2843 643-650 NN denotes removal
T2844 651-653 IN denotes of
T2845 654-665 NN denotes doxycycline
T2846 666-670 IN denotes from
T2847 671-674 DT denotes the
T2848 675-682 NN denotes culture
T2849 683-688 NNS denotes media
T2850 689-692 IN denotes for
T2851 693-694 CD denotes 5
T2852 695-699 NNS denotes days
T2853 700-707 NNS denotes results
T2854 708-710 IN denotes in
T2855 711-712 DT denotes a
T2856 713-723 RB denotes completely
T2857 724-728 JJ denotes null
T2858 729-732 NNP denotes PKD
T2859 733-742 NN denotes phenotype
T2860 743-744 -LRB- denotes (
T2861 744-748 NNP denotes Fig.
T2862 749-751 NNP denotes 1A
T2863 751-752 -RRB- denotes )
T2864 752-753 . denotes .
T2865 754-764 RB denotes Previously
T2866 764-765 , denotes ,
T2867 766-768 PRP denotes we
T2868 769-773 VBP denotes have
T2869 774-786 VBN denotes demonstrated
T2870 787-791 IN denotes that
T2871 792-807 NN denotes phosphorylation
T2872 808-811 CC denotes and
T2873 812-819 JJ denotes nuclear
T2874 820-829 NN denotes exclusion
T2875 830-832 IN denotes of
T2876 833-838 NN denotes class
T2877 839-841 NNP denotes II
T2878 842-849 NN denotes histone
T2879 850-862 NNS denotes deacetylases
T2880 863-864 -LRB- denotes (
T2881 864-869 NNS denotes HDACs
T2882 869-870 -RRB- denotes )
T2883 871-877 IN denotes during
T2884 878-881 NNP denotes BCR
T2885 882-892 NN denotes engagement
T2886 893-895 VBZ denotes is
T2887 896-905 JJ denotes defective
T2888 906-908 IN denotes in
T2889 909-915 CD denotes PKD1/3
T2890 915-916 CD denotes −
T2891 916-917 NN denotes /
T2892 917-918 NN denotes −
T2893 919-920 NNP denotes B
T2894 921-926 NNS denotes cells
T2895 927-930 CC denotes and
T2896 931-934 MD denotes can
T2897 935-943 VBD denotes restored
T2898 944-948 IN denotes upon
T2899 949-962 NN denotes re-expression
T2900 963-965 IN denotes of
T2901 966-967 DT denotes a
T2902 968-974 JJ denotes single
T2903 975-978 NNP denotes PKD
T2904 979-986 NN denotes isoform
T2905 987-988 NNP denotes [
T2906 988-989 CD denotes 1
T2907 989-990 NNP denotes ]
T2908 990-991 . denotes .
T2909 992-995 DT denotes The
T2910 996-1001 JJ denotes small
T2911 1002-1006 NN denotes heat
T2912 1007-1012 NN denotes shock
T2913 1013-1020 NN denotes protein
T2914 1021-1026 NNP denotes HSP27
T2915 1027-1030 VBZ denotes has
T2916 1031-1039 RB denotes recently
T2917 1040-1044 VBN denotes been
T2918 1045-1053 VBN denotes proposed
T2919 1054-1056 IN denotes as
T2920 1057-1058 DT denotes a
T2921 1059-1063 NNP denotes PKD1
T2922 1064-1073 VB denotes substrate
T2923 1074-1075 NNP denotes [
T2924 1075-1077 CD denotes 24
T2925 1077-1078 NNP denotes ]
T2926 1079-1082 CC denotes and
T2927 1083-1085 PRP denotes we
T2928 1086-1097 RB denotes accordingly
T2929 1098-1106 VBD denotes assessed
T2930 1107-1114 IN denotes whether
T2931 1115-1123 NNP denotes PKD-null
T2932 1124-1128 NNP denotes DT40
T2933 1129-1134 NNS denotes cells
T2934 1135-1139 VBP denotes have
T2935 1140-1149 JJ denotes defective
T2936 1150-1165 NN denotes phosphorylation
T2937 1166-1168 IN denotes of
T2938 1169-1174 NNP denotes HSP27
T2939 1175-1177 IN denotes on
T2940 1178-1184 NN denotes serine
T2941 1185-1187 CD denotes 82
T2942 1187-1188 , denotes ,
T2943 1189-1192 DT denotes the
T2944 1193-1201 VBN denotes proposed
T2945 1202-1206 NNP denotes PKD1
T2946 1207-1216 VB denotes substrate
T2947 1217-1225 NN denotes sequence
T2948 1225-1226 . denotes .
T2949 1227-1229 PRP denotes We
T2950 1230-1239 RB denotes initially
T2951 1240-1252 VBD denotes investigated
T2952 1253-1256 DT denotes the
T2953 1257-1267 NN denotes regulation
T2954 1268-1270 IN denotes of
T2955 1271-1276 NNP denotes HSP27
T2956 1277-1292 NN denotes phosphorylation
T2957 1293-1295 IN denotes in
T2958 1296-1302 JJ denotes single
T2959 1303-1311 NN denotes knockout
T2960 1312-1316 NNP denotes DT40
T2961 1317-1318 NNP denotes B
T2962 1319-1324 NNS denotes cells
T2963 1325-1332 VBG denotes lacking
T2964 1333-1339 CC denotes either
T2965 1340-1344 CD denotes PKD1
T2966 1345-1347 CC denotes or
T2967 1348-1352 CD denotes PKD3
T2968 1352-1353 . denotes .
T2969 1354-1356 IN denotes As
T2970 1357-1362 VBN denotes shown
T2971 1363-1365 IN denotes in
T2972 1366-1370 NNP denotes Fig.
T2973 1371-1373 NNP denotes 1B
T2974 1373-1374 , denotes ,
T2975 1375-1385 NN denotes activation
T2976 1386-1388 IN denotes of
T2977 1389-1392 DT denotes the
T2978 1393-1396 NNP denotes BCR
T2979 1397-1399 CC denotes or
T2980 1400-1409 NN denotes treatment
T2981 1410-1414 IN denotes with
T2982 1415-1418 DT denotes the
T2983 1419-1430 JJ denotes DAG-mimetic
T2984 1431-1435 NNP denotes PdBu
T2985 1436-1445 VBD denotes increased
T2986 1446-1449 DT denotes the
T2987 1450-1456 NNS denotes levels
T2988 1457-1459 IN denotes of
T2989 1460-1465 NNP denotes HSP27
T2990 1466-1481 NN denotes phosphorylation
T2991 1482-1484 IN denotes at
T2992 1485-1488 CD denotes S82
T2993 1489-1491 IN denotes in
T2994 1492-1501 JJ denotes wild-type
T2995 1502-1506 NNP denotes DT40
T2996 1507-1508 NNP denotes B
T2997 1509-1514 NNS denotes cells
T2998 1514-1515 . denotes .
T2999 1516-1519 NNP denotes BCR
T3000 1520-1523 CC denotes and
T3001 1524-1531 JJ denotes phorbol
T3002 1532-1537 NN denotes ester
T3003 1538-1545 NNS denotes signals
T3004 1546-1550 VBD denotes were
T3005 1551-1555 RB denotes also
T3006 1556-1560 JJ denotes able
T3007 1561-1563 TO denotes to
T3008 1564-1572 VB denotes increase
T3009 1573-1578 NNP denotes HSP27
T3010 1579-1594 NN denotes phosphorylation
T3011 1595-1597 IN denotes in
T3012 1598-1602 CD denotes PKD1
T3013 1603-1605 CC denotes or
T3014 1606-1610 CD denotes PKD3
T3015 1611-1617 JJ denotes single
T3016 1618-1626 NN denotes knockout
T3017 1627-1631 NNP denotes DT40
T3018 1632-1633 NNP denotes B
T3019 1634-1639 NNS denotes cells
T3020 1640-1641 -LRB- denotes (
T3021 1641-1645 NNP denotes Fig.
T3022 1646-1648 NNP denotes 1B
T3023 1648-1649 -RRB- denotes )
T3024 1649-1650 . denotes .
T3025 1651-1658 RB denotes However
T3026 1658-1659 , denotes ,
T3027 1660-1663 NNP denotes BCR
T3028 1663-1664 : denotes -
T3029 1665-1668 CC denotes and
T3030 1669-1676 VB denotes phorbol
T3031 1677-1690 JJ denotes ester-induced
T3032 1691-1706 NN denotes phosphorylation
T3033 1707-1709 IN denotes of
T3034 1710-1715 NNP denotes HSP27
T3035 1716-1718 IN denotes on
T3036 1719-1722 NNP denotes S82
T3037 1723-1726 VBD denotes was
T3038 1727-1736 VBN denotes abolished
T3039 1737-1739 IN denotes in
T3040 1740-1741 NNP denotes B
T3041 1742-1747 NNS denotes cells
T3042 1748-1752 WDT denotes that
T3043 1753-1759 VBD denotes lacked
T3044 1760-1764 DT denotes both
T3045 1765-1769 NNP denotes PKD1
T3046 1770-1773 CC denotes and
T3047 1774-1778 NNP denotes PKD3
T3048 1779-1780 -LRB- denotes (
T3049 1780-1784 NNP denotes Fig.
T3050 1785-1787 NNP denotes 1C
T3051 1787-1788 -RRB- denotes )
T3052 1788-1789 . denotes .
T3053 1790-1803 RB denotes Significantly
T3054 1803-1804 , denotes ,
T3055 1805-1824 JJ denotes doxycycline-induced
T3056 1825-1835 NN denotes expression
T3057 1836-1838 IN denotes of
T3058 1839-1842 DT denotes the
T3059 1843-1852 NN denotes Flag-PKD3
T3060 1853-1862 NN denotes transgene
T3061 1863-1865 IN denotes in
T3062 1866-1869 DT denotes the
T3063 1870-1876 JJ denotes double
T3064 1877-1885 NN denotes knockout
T3065 1886-1891 NNS denotes cells
T3066 1892-1895 VBD denotes was
T3067 1896-1906 JJ denotes sufficient
T3068 1907-1909 TO denotes to
T3069 1910-1917 VB denotes restore
T3070 1918-1924 JJ denotes normal
T3071 1925-1935 NN denotes regulation
T3072 1936-1938 IN denotes of
T3073 1939-1944 NNP denotes HSP27
T3074 1945-1960 NN denotes phosphorylation
T3075 1961-1962 -LRB- denotes (
T3076 1962-1966 NNP denotes Fig.
T3077 1967-1969 NNP denotes 1C
T3078 1969-1970 -RRB- denotes )
T3079 1970-1971 . denotes .
T3080 1972-1974 IN denotes In
T3081 1975-1983 NN denotes contrast
T3082 1983-1984 , denotes ,
T3083 1985-1995 NN denotes expression
T3084 1996-1998 IN denotes of
T3085 1999-2000 DT denotes a
T3086 2001-2017 JJ denotes kinase-deficient
T3087 2018-2022 NN denotes PKD3
T3088 2023-2029 JJ denotes mutant
T3089 2030-2037 NN denotes protein
T3090 2038-2040 IN denotes in
T3091 2041-2044 DT denotes the
T3092 2045-2051 JJ denotes double
T3093 2052-2060 NN denotes knockout
T3094 2061-2066 NNS denotes cells
T3095 2067-2070 VBD denotes was
T3096 2071-2074 RB denotes not
T3097 2075-2079 JJ denotes able
T3098 2080-2082 TO denotes to
T3099 2083-2090 VB denotes restore
T3100 2091-2094 NNP denotes BCR
T3101 2094-2095 : denotes -
T3102 2096-2098 CC denotes or
T3103 2099-2106 VB denotes phorbol
T3104 2107-2120 JJ denotes ester-induced
T3105 2121-2126 NNP denotes HSP27
T3106 2127-2142 NN denotes phosphorylation
T3107 2143-2144 -LRB- denotes (
T3108 2144-2148 NNP denotes Fig.
T3109 2149-2151 NNP denotes 1D
T3110 2151-2152 -RRB- denotes )
T3111 2152-2153 . denotes .
T3112 2154-2159 RB denotes Hence
T3113 2159-2160 , denotes ,
T3114 2161-2165 NNP denotes PKD3
T3115 2166-2168 RB denotes as
T3116 2169-2173 RB denotes well
T3117 2174-2176 IN denotes as
T3118 2177-2181 NNP denotes PKD1
T3119 2182-2185 MD denotes can
T3120 2186-2194 VB denotes regulate
T3121 2195-2200 NNP denotes HSP27
T3122 2201-2216 NN denotes phosphorylation
T3123 2217-2220 CC denotes and
T3124 2221-2223 IN denotes in
T3125 2224-2228 NNP denotes DT40
T3126 2229-2230 NNP denotes B
T3127 2231-2236 NNS denotes cells
T3128 2237-2241 PRP denotes they
T3129 2242-2245 VBP denotes are
T3130 2246-2258 RB denotes functionally
T3131 2259-2268 JJ denotes redundant
T3132 2269-2271 IN denotes as
T3133 2272-2277 NNP denotes HSP27
T3134 2278-2285 NNS denotes kinases
T3135 2285-2286 . denotes .
T4218 2293-2301 NNP denotes Cellular
T4219 2302-2315 NN denotes proliferation
T4220 2316-2319 CC denotes and
T4221 2320-2328 NN denotes survival
T4222 2329-2331 IN denotes in
T4223 2332-2336 NNP denotes DT40
T4224 2337-2338 NNP denotes B
T4225 2339-2344 NNS denotes cells
T4226 2345-2352 VBG denotes lacking
T4227 2353-2363 NN denotes expression
T4228 2364-2366 IN denotes of
T4229 2367-2370 NNP denotes PKD
T4230 2371-2377 NN denotes family
T4231 2378-2385 VBZ denotes kinases
T4232 2386-2389 NNP denotes PKD
T4233 2390-2397 NNS denotes enzymes
T4234 2398-2402 VBP denotes have
T4235 2403-2413 RB denotes previously
T4236 2414-2418 VBN denotes been
T4237 2419-2425 VBN denotes linked
T4238 2426-2428 TO denotes to
T4239 2429-2432 DT denotes the
T4240 2433-2443 NN denotes regulation
T4241 2444-2446 IN denotes of
T4242 2447-2451 NN denotes cell
T4243 2452-2465 NN denotes proliferation
T4244 2466-2469 CC denotes and
T4245 2470-2478 NN denotes survival
T4246 2479-2480 -LRB- denotes (
T4247 2480-2488 VBN denotes reviewed
T4248 2489-2491 IN denotes in
T4249 2492-2493 NNP denotes [
T4250 2493-2495 CD denotes 20
T4251 2495-2496 NNP denotes ]
T4252 2496-2497 -RRB- denotes )
T4253 2497-2498 . denotes .
T4254 2499-2501 TO denotes To
T4255 2502-2513 VB denotes investigate
T4256 2514-2517 DT denotes the
T4257 2518-2524 NN denotes effect
T4258 2525-2529 WDT denotes that
T4259 2530-2534 NN denotes loss
T4260 2535-2537 IN denotes of
T4261 2538-2541 NNP denotes PKD
T4262 2542-2549 NNS denotes kinases
T4263 2550-2553 VBD denotes had
T4264 2554-2556 IN denotes on
T4265 2557-2558 NNP denotes B
T4266 2559-2563 NN denotes cell
T4267 2564-2572 NN denotes survival
T4268 2573-2579 CC denotes and/or
T4269 2580-2593 NN denotes proliferation
T4270 2594-2596 PRP denotes we
T4271 2597-2605 VBD denotes cultured
T4272 2606-2615 JJ denotes wild-type
T4273 2616-2619 CC denotes and
T4274 2620-2628 JJ denotes PKD-null
T4275 2629-2634 NNS denotes cells
T4276 2635-2637 IN denotes in
T4277 2638-2641 DT denotes the
T4278 2642-2650 NN denotes presence
T4279 2651-2652 -LRB- denotes (
T4280 2652-2658 CD denotes PKD1/3
T4281 2658-2659 CD denotes −
T4282 2659-2660 NN denotes /
T4283 2660-2661 NN denotes −
T4284 2661-2662 : denotes :
T4285 2663-2672 NN denotes Flag-PKD3
T4286 2672-2673 NN denotes +
T4287 2673-2675 NN denotes ve
T4288 2675-2676 -RRB- denotes )
T4289 2677-2679 CC denotes or
T4290 2680-2687 NN denotes absence
T4291 2688-2689 -LRB- denotes (
T4292 2689-2695 CD denotes PKD1/3
T4293 2695-2696 CD denotes −
T4294 2696-2697 NN denotes /
T4295 2697-2698 NN denotes −
T4296 2698-2699 -RRB- denotes )
T4297 2700-2702 IN denotes of
T4298 2703-2714 NN denotes doxycycline
T4299 2715-2718 CC denotes and
T4300 2719-2728 VBD denotes monitored
T4301 2729-2740 JJ denotes exponential
T4302 2741-2747 NN denotes growth
T4303 2747-2748 . denotes .
T4304 2749-2751 IN denotes As
T4305 2752-2757 VBN denotes shown
T4306 2758-2760 IN denotes in
T4307 2761-2765 NNP denotes Fig.
T4308 2766-2768 NNP denotes 2A
T4309 2768-2769 , denotes ,
T4310 2770-2776 NNP denotes PKD1/3
T4311 2776-2777 VBD denotes −
T4312 2777-2778 CD denotes /
T4313 2778-2779 NN denotes −
T4314 2780-2785 NNS denotes cells
T4315 2786-2798 VBD denotes proliferated
T4316 2799-2812 RB denotes exponentially
T4317 2813-2816 CC denotes and
T4318 2817-2830 NN denotes re-expression
T4319 2831-2833 IN denotes of
T4320 2834-2843 NN denotes Flag-PKD3
T4321 2844-2846 IN denotes in
T4322 2847-2852 DT denotes these
T4323 2853-2858 NNS denotes cells
T4324 2859-2862 VBD denotes had
T4325 2863-2865 DT denotes no
T4326 2866-2872 NN denotes impact
T4327 2873-2875 IN denotes on
T4328 2876-2879 DT denotes the
T4329 2880-2884 NN denotes rate
T4330 2885-2887 IN denotes of
T4331 2888-2901 NN denotes proliferation
T4332 2901-2902 . denotes .
T4333 2903-2914 RB denotes Furthermore
T4334 2914-2915 , denotes ,
T4335 2916-2919 DT denotes the
T4336 2920-2929 NN denotes viability
T4337 2930-2932 IN denotes of
T4338 2933-2939 CD denotes PKD1/3
T4339 2939-2940 CD denotes −
T4340 2940-2941 NN denotes /
T4341 2941-2942 NN denotes −
T4342 2943-2944 NNP denotes B
T4343 2945-2950 NNS denotes cells
T4344 2951-2957 IN denotes during
T4345 2958-2965 JJ denotes routine
T4346 2966-2975 NN denotes culturing
T4347 2976-2979 VBD denotes was
T4348 2980-2983 RB denotes not
T4349 2984-2997 RB denotes significantly
T4350 2998-3007 JJ denotes different
T4351 3008-3012 IN denotes from
T4352 3013-3017 DT denotes that
T4353 3018-3020 IN denotes of
T4354 3021-3030 JJ denotes wild-type
T4355 3031-3032 NNP denotes B
T4356 3033-3038 NNS denotes cells
T4357 3039-3040 -LRB- denotes (
T4358 3040-3044 NNS denotes data
T4359 3045-3048 RB denotes not
T4360 3049-3054 VBN denotes shown
T4361 3054-3055 -RRB- denotes )
T4362 3055-3056 . denotes .
T4363 3057-3059 PRP denotes It
T4364 3060-3063 VBD denotes was
T4365 3064-3069 VBN denotes noted
T4366 3070-3074 IN denotes that
T4367 3075-3078 DT denotes the
T4368 3079-3089 NN denotes population
T4369 3090-3098 VBG denotes doubling
T4370 3099-3103 NN denotes time
T4371 3104-3106 IN denotes of
T4372 3107-3113 CD denotes PKD1/3
T4373 3113-3114 CD denotes −
T4374 3114-3115 NN denotes /
T4375 3115-3116 NN denotes −
T4376 3117-3122 NNS denotes cells
T4377 3123-3126 VBD denotes was
T4378 3127-3135 RB denotes slightly
T4379 3136-3142 JJR denotes slower
T4380 3143-3147 IN denotes than
T4381 3148-3152 DT denotes that
T4382 3153-3155 IN denotes of
T4383 3156-3160 JJ denotes wild
T4384 3161-3165 NN denotes type
T4385 3166-3170 CD denotes DT40
T4386 3171-3176 NNS denotes cells
T4387 3177-3178 -LRB- denotes (
T4388 3178-3182 CD denotes 12.7
T4389 3183-3184 CD denotes ±
T4390 3185-3188 CD denotes 2.8
T4391 3189-3190 NN denotes h
T4392 3191-3197 IN denotes versus
T4393 3198-3202 CD denotes 10.2
T4394 3203-3204 CD denotes ±
T4395 3205-3208 CD denotes 0.4
T4396 3209-3210 NN denotes h
T4397 3210-3211 -RRB- denotes )
T4398 3212-3215 CC denotes but
T4399 3216-3219 DT denotes the
T4400 3220-3227 NN denotes failure
T4401 3228-3230 IN denotes of
T4402 3231-3235 CD denotes PKD3
T4403 3236-3249 NN denotes re-expression
T4404 3250-3252 TO denotes to
T4405 3253-3259 VB denotes modify
T4406 3260-3263 DT denotes the
T4407 3264-3277 NN denotes proliferation
T4408 3278-3282 NN denotes rate
T4409 3283-3285 IN denotes of
T4410 3286-3292 CD denotes PKD1/3
T4411 3292-3293 CD denotes −
T4412 3293-3294 NN denotes /
T4413 3294-3295 NN denotes −
T4414 3296-3301 NNS denotes cells
T4415 3302-3310 VBZ denotes suggests
T4416 3311-3315 IN denotes that
T4417 3316-3321 DT denotes these
T4418 3322-3327 JJ denotes small
T4419 3328-3339 NNS denotes differences
T4420 3340-3344 VBD denotes were
T4421 3345-3349 RBS denotes most
T4422 3350-3356 JJ denotes likely
T4423 3357-3360 DT denotes the
T4424 3361-3367 NN denotes result
T4425 3368-3370 IN denotes of
T4426 3371-3377 JJ denotes clonal
T4427 3378-3387 NN denotes variation
T4428 3388-3391 CC denotes and
T4429 3392-3396 VBD denotes were
T4430 3397-3400 RB denotes not
T4431 3401-3407 VBN denotes caused
T4432 3408-3420 RB denotes specifically
T4433 3421-3423 IN denotes by
T4434 3424-3428 NN denotes loss
T4435 3429-3431 IN denotes of
T4436 3432-3435 NNP denotes PKD
T4437 3436-3443 VBZ denotes enzymes
T4438 3443-3444 . denotes .
T4439 3445-3449 RB denotes Thus
T4440 3449-3450 , denotes ,
T4441 3451-3454 NNP denotes PKD
T4442 3455-3461 NN denotes family
T4443 3462-3469 NNS denotes enzymes
T4444 3470-3473 VBP denotes are
T4445 3474-3477 RB denotes not
T4446 3478-3487 JJ denotes essential
T4447 3488-3491 IN denotes for
T4448 3492-3502 VBG denotes regulating
T4449 3503-3508 JJ denotes basal
T4450 3509-3517 NN denotes survival
T4451 3518-3521 CC denotes and
T4452 3522-3535 NN denotes proliferation
T4453 3536-3538 IN denotes of
T4454 3539-3543 NNP denotes DT40
T4455 3544-3545 NNP denotes B
T4456 3546-3551 NNS denotes cells
T4457 3551-3552 . denotes .
T4458 3553-3556 NNP denotes PKD
T4459 3557-3564 VBZ denotes enzymes
T4460 3564-3565 , denotes ,
T4461 3566-3578 RB denotes specifically
T4462 3579-3583 CD denotes PKD1
T4463 3584-3587 CC denotes and
T4464 3588-3592 NNP denotes PKD2
T4465 3592-3593 , denotes ,
T4466 3594-3598 VBP denotes have
T4467 3599-3609 RB denotes previously
T4468 3610-3614 VBN denotes been
T4469 3615-3621 VBN denotes linked
T4470 3622-3624 TO denotes to
T4471 3625-3626 DT denotes a
T4472 3627-3637 JJ denotes protective
T4473 3638-3642 NN denotes role
T4474 3643-3650 IN denotes against
T4475 3651-3660 JJ denotes oxidative
T4476 3661-3675 JJ denotes stress-induced
T4477 3676-3682 NN denotes injury
T4478 3683-3685 IN denotes in
T4479 3686-3689 NNP denotes 3T3
T4480 3690-3700 NN denotes fibroblast
T4481 3700-3701 , denotes ,
T4482 3702-3706 NNP denotes HeLa
T4483 3707-3710 CC denotes and
T4484 3711-3721 JJ denotes epithelial
T4485 3722-3726 NN denotes cell
T4486 3727-3732 NNS denotes lines
T4487 3733-3734 NNP denotes [
T4488 3734-3739 CD denotes 17,30
T4489 3740-3742 CD denotes 32
T4490 3742-3743 NN denotes ]
T4491 3743-3744 . denotes .
T4492 3745-3747 PRP denotes We
T4493 3748-3757 RB denotes therefore
T4494 3758-3767 VBD denotes addressed
T4495 3768-3771 DT denotes the
T4496 3772-3776 NN denotes role
T4497 3777-3779 IN denotes of
T4498 3780-3783 NNP denotes PKD
T4499 3784-3790 NN denotes family
T4500 3791-3798 NNS denotes kinases
T4501 3799-3801 IN denotes in
T4502 3802-3812 VBG denotes regulating
T4503 3813-3814 NNP denotes B
T4504 3815-3819 NN denotes cell
T4505 3820-3828 NN denotes survival
T4506 3829-3831 IN denotes in
T4507 3832-3840 NN denotes response
T4508 3841-3843 TO denotes to
T4509 3844-3853 JJ denotes oxidative
T4510 3854-3860 NN denotes stress
T4511 3861-3864 CC denotes and
T4512 3865-3870 JJ denotes other
T4513 3871-3877 NN denotes stress
T4514 3878-3885 NNS denotes stimuli
T4515 3885-3886 . denotes .
T4516 3887-3889 IN denotes As
T4517 3890-3895 VBN denotes shown
T4518 3896-3898 IN denotes in
T4519 3899-3903 NNP denotes Fig.
T4520 3904-3906 NNP denotes 2B
T4521 3906-3907 , denotes ,
T4522 3908-3912 NN denotes loss
T4523 3913-3915 IN denotes of
T4524 3916-3922 CD denotes PKD1/3
T4525 3923-3933 NN denotes expression
T4526 3934-3937 VBD denotes had
T4527 3938-3940 DT denotes no
T4528 3941-3952 JJ denotes significant
T4529 3953-3959 NN denotes impact
T4530 3960-3962 IN denotes on
T4531 3963-3966 DT denotes the
T4532 3967-3975 NN denotes survival
T4533 3976-3978 IN denotes of
T4534 3979-3983 NNP denotes DT40
T4535 3984-3985 NNP denotes B
T4536 3986-3991 NNS denotes cells
T4537 3992-3994 IN denotes in
T4538 3995-4003 NN denotes response
T4539 4004-4006 TO denotes to
T4540 4007-4020 JJ denotes mitochondrial
T4541 4021-4027 NN denotes stress
T4542 4028-4035 NNS denotes stimuli
T4543 4036-4037 -LRB- denotes (
T4544 4037-4041 CD denotes H2O2
T4545 4042-4044 CC denotes or
T4546 4045-4050 NN denotes serum
T4547 4051-4062 NN denotes deprivation
T4548 4062-4063 -RRB- denotes )
T4549 4063-4064 : denotes ;
T4550 4065-4068 NNP denotes DNA
T4551 4069-4077 VBG denotes damaging
T4552 4078-4084 NNS denotes agents
T4553 4085-4086 -LRB- denotes (
T4554 4086-4095 NN denotes etoposide
T4555 4096-4098 CC denotes or
T4556 4099-4110 NN denotes doxorubicin
T4557 4110-4111 -RRB- denotes )
T4558 4111-4112 : denotes ;
T4559 4113-4115 NNP denotes ER
T4560 4116-4123 NN denotes pathway
T4561 4124-4130 NN denotes stress
T4562 4131-4134 JJ denotes due
T4563 4135-4137 TO denotes to
T4564 4138-4145 NN denotes calcium
T4565 4146-4154 NN denotes overload
T4566 4155-4156 -LRB- denotes (
T4567 4156-4168 NN denotes thapsigargin
T4568 4168-4169 -RRB- denotes )
T4569 4170-4172 CC denotes or
T4570 4173-4182 VBG denotes following
T4571 4183-4192 JJ denotes prolonged
T4572 4193-4202 NN denotes treatment
T4573 4203-4207 IN denotes with
T4574 4208-4215 NN denotes phorbol
T4575 4216-4222 NNS denotes esters
T4576 4223-4225 CC denotes or
T4577 4226-4238 NNP denotes Trichostatin
T4578 4239-4240 NNP denotes A
T4579 4240-4241 , denotes ,
T4580 4242-4244 DT denotes an
T4581 4245-4254 NN denotes inhibitor
T4582 4255-4257 IN denotes of
T4583 4258-4263 NN denotes class
T4584 4264-4268 NNP denotes I/II
T4585 4269-4274 NNP denotes HDACs
T4586 4274-4275 . denotes .
T4587 4276-4280 RB denotes Thus
T4588 4280-4281 , denotes ,
T4589 4282-4285 NNP denotes PKD
T4590 4286-4293 NNS denotes kinases
T4591 4294-4296 VBP denotes do
T4592 4297-4300 RB denotes not
T4593 4301-4305 VB denotes play
T4594 4306-4308 DT denotes an
T4595 4309-4318 JJ denotes essential
T4596 4319-4323 NN denotes role
T4597 4324-4326 IN denotes in
T4598 4327-4337 VBG denotes regulating
T4599 4338-4339 NNP denotes B
T4600 4340-4344 NN denotes cell
T4601 4345-4353 NN denotes survival
T4602 4354-4356 IN denotes in
T4603 4357-4365 NN denotes response
T4604 4366-4368 TO denotes to
T4605 4369-4370 DT denotes a
T4606 4371-4376 NN denotes range
T4607 4377-4379 IN denotes of
T4608 4380-4389 JJ denotes different
T4609 4390-4396 NN denotes stress
T4610 4397-4404 NNS denotes stimuli
T4611 4404-4405 . denotes .
T5769 4412-4419 NN denotes Antigen
T5770 4420-4428 NN denotes receptor
T5771 4429-4438 VBN denotes regulated
T5772 4439-4449 JJ denotes signalling
T5773 4450-4458 NNS denotes pathways
T5774 4459-4461 IN denotes in
T5775 4462-4470 NNP denotes PKD-null
T5776 4471-4475 NNP denotes DT40
T5777 4476-4477 NNP denotes B
T5778 4478-4483 NNS denotes cells
T5779 4484-4486 TO denotes To
T5780 4487-4494 RBR denotes further
T5781 4495-4502 VB denotes explore
T5782 4503-4506 DT denotes the
T5783 4507-4519 NN denotes contribution
T5784 4520-4522 IN denotes of
T5785 4523-4526 NNP denotes PKD
T5786 4527-4534 VBZ denotes kinases
T5787 4535-4537 TO denotes to
T5788 4538-4542 NNP denotes DT40
T5789 4543-4544 NNP denotes B
T5790 4545-4549 NN denotes cell
T5791 4550-4557 NN denotes biology
T5792 4558-4560 PRP denotes we
T5793 4561-4573 VBD denotes investigated
T5794 4574-4581 IN denotes whether
T5795 4582-4590 JJ denotes specific
T5796 4591-4604 JJ denotes BCR-regulated
T5797 4605-4615 JJ denotes signalling
T5798 4616-4622 NNS denotes events
T5799 4623-4627 VBD denotes were
T5800 4628-4637 JJ denotes defective
T5801 4638-4640 IN denotes in
T5802 4641-4644 DT denotes the
T5803 4645-4653 NNP denotes PKD-null
T5804 4654-4655 NNP denotes B
T5805 4656-4661 NNS denotes cells
T5806 4661-4662 . denotes .
T5807 4663-4670 JJ denotes Initial
T5808 4671-4682 NNS denotes experiments
T5809 4683-4691 VBD denotes revealed
T5810 4692-4696 IN denotes that
T5811 4697-4704 NN denotes surface
T5812 4705-4715 NN denotes expression
T5813 4716-4718 IN denotes of
T5814 4719-4722 DT denotes the
T5815 4723-4726 NNP denotes BCR
T5816 4727-4730 VBD denotes was
T5817 4731-4738 VBN denotes reduced
T5818 4739-4741 IN denotes in
T5819 4742-4748 CD denotes PKD1/3
T5820 4748-4749 CD denotes −
T5821 4749-4750 NN denotes /
T5822 4750-4751 NN denotes −
T5823 4752-4753 -LRB- denotes (
T5824 4753-4756 CC denotes and
T5825 4757-4759 IN denotes in
T5826 4760-4766 CD denotes PKD1/3
T5827 4766-4767 CD denotes −
T5828 4767-4768 NN denotes /
T5829 4768-4769 NN denotes −
T5830 4769-4770 : denotes :
T5831 4770-4779 NN denotes Flag-PKD3
T5832 4779-4780 NN denotes +
T5833 4780-4782 NN denotes ve
T5834 4782-4783 -RRB- denotes )
T5835 4784-4789 NNS denotes cells
T5836 4790-4798 VBN denotes compared
T5837 4799-4801 TO denotes to
T5838 4802-4811 JJ denotes wild-type
T5839 4812-4816 NNP denotes DT40
T5840 4817-4818 NNP denotes B
T5841 4819-4824 NNS denotes cells
T5842 4825-4826 -LRB- denotes (
T5843 4826-4830 NNP denotes Fig.
T5844 4831-4833 NNP denotes 3A
T5845 4834-4837 CC denotes and
T5846 4838-4842 NNS denotes data
T5847 4843-4846 RB denotes not
T5848 4847-4852 VBN denotes shown
T5849 4852-4853 -RRB- denotes )
T5850 4853-4854 . denotes .
T5851 4855-4867 RB denotes Nevertheless
T5852 4867-4868 , denotes ,
T5853 4869-4885 JJ denotes BCR-crosslinking
T5854 4886-4888 IN denotes of
T5855 4889-4895 CD denotes PKD1/3
T5856 4895-4896 CD denotes −
T5857 4896-4897 NN denotes /
T5858 4897-4898 NN denotes −
T5859 4899-4904 NNS denotes cells
T5860 4905-4908 VBD denotes was
T5861 4909-4919 JJ denotes sufficient
T5862 4920-4922 TO denotes to
T5863 4923-4929 VB denotes induce
T5864 4930-4933 DT denotes the
T5865 4934-4944 NN denotes activation
T5866 4945-4947 IN denotes of
T5867 4948-4949 DT denotes a
T5868 4950-4956 NN denotes number
T5869 4957-4959 IN denotes of
T5870 4960-4970 VBG denotes signalling
T5871 4971-4979 NNS denotes cascades
T5872 4979-4980 , denotes ,
T5873 4981-4988 JJ denotes similar
T5874 4989-4991 TO denotes to
T5875 4992-4996 DT denotes that
T5876 4997-5005 VBN denotes observed
T5877 5006-5008 IN denotes in
T5878 5009-5018 JJ denotes wild-type
T5879 5019-5024 NNS denotes cells
T5880 5025-5026 -LRB- denotes (
T5881 5026-5030 NNP denotes Fig.
T5882 5031-5033 NNP denotes 3B
T5883 5033-5034 -RRB- denotes )
T5884 5034-5035 . denotes .
T5885 5036-5041 RB denotes Hence
T5886 5041-5042 , denotes ,
T5887 5043-5054 JJ denotes BCR-induced
T5888 5055-5065 NN denotes activation
T5889 5066-5068 IN denotes of
T5890 5069-5072 DT denotes the
T5891 5073-5076 NNP denotes Akt
T5892 5076-5077 , denotes ,
T5893 5078-5086 NNP denotes mTOR/p70
T5894 5087-5089 NNP denotes S6
T5895 5090-5096 NN denotes kinase
T5896 5097-5098 -LRB- denotes (
T5897 5098-5100 IN denotes as
T5898 5101-5106 VBN denotes shown
T5899 5107-5109 IN denotes by
T5900 5110-5112 CD denotes S6
T5901 5113-5122 JJ denotes ribosomal
T5902 5123-5130 NN denotes protein
T5903 5131-5146 NN denotes phosphorylation
T5904 5146-5147 -RRB- denotes )
T5905 5148-5151 CC denotes and
T5906 5152-5156 NNP denotes MAPK
T5907 5157-5167 VBG denotes signalling
T5908 5168-5176 NNS denotes pathways
T5909 5177-5180 VBD denotes was
T5910 5181-5188 RB denotes clearly
T5911 5189-5199 JJ denotes detectable
T5912 5200-5202 IN denotes in
T5913 5203-5214 NNP denotes PKD1/3-null
T5914 5215-5216 NNP denotes B
T5915 5217-5222 NNS denotes cells
T5916 5223-5224 -LRB- denotes (
T5917 5224-5228 NNP denotes Fig.
T5918 5229-5231 NNP denotes 3B
T5919 5231-5232 -RRB- denotes )
T5920 5232-5233 . denotes .
T5921 5234-5245 RB denotes Furthermore
T5922 5245-5246 , denotes ,
T5923 5247-5255 JJ denotes enhanced
T5924 5256-5264 NN denotes tyrosine
T5925 5265-5280 NN denotes phosphorylation
T5926 5281-5283 IN denotes of
T5927 5284-5292 JJ denotes multiple
T5928 5293-5301 JJ denotes cellular
T5929 5302-5310 NNS denotes proteins
T5930 5311-5313 RB denotes as
T5931 5314-5318 RB denotes well
T5932 5319-5321 IN denotes as
T5933 5322-5324 DT denotes an
T5934 5325-5333 NN denotes increase
T5935 5334-5336 IN denotes in
T5936 5337-5350 JJ denotes intracellular
T5937 5351-5358 NN denotes calcium
T5938 5359-5365 NNS denotes levels
T5939 5366-5369 VBD denotes was
T5940 5370-5374 RB denotes also
T5941 5375-5383 VBN denotes observed
T5942 5384-5393 VBG denotes following
T5943 5394-5397 NNP denotes BCR
T5944 5398-5409 NN denotes stimulation
T5945 5410-5412 IN denotes of
T5946 5413-5424 NNP denotes PKD1/3-null
T5947 5425-5426 NNP denotes B
T5948 5427-5432 NNS denotes cells
T5949 5433-5434 -LRB- denotes (
T5950 5434-5438 NNS denotes data
T5951 5439-5442 RB denotes not
T5952 5443-5448 VBN denotes shown
T5953 5448-5449 -RRB- denotes )
T5954 5449-5450 . denotes .
T5955 5451-5453 PRP denotes We
T5956 5454-5457 VBD denotes did
T5957 5458-5465 VB denotes observe
T5958 5466-5470 IN denotes that
T5959 5471-5474 DT denotes the
T5960 5475-5483 NN denotes strength
T5961 5484-5486 IN denotes of
T5962 5487-5490 NNP denotes BCR
T5963 5491-5492 -LRB- denotes (
T5964 5492-5495 CC denotes but
T5965 5496-5499 RB denotes not
T5966 5500-5507 VB denotes phorbol
T5967 5508-5513 NN denotes ester
T5968 5513-5514 -RRB- denotes )
T5969 5514-5515 : denotes -
T5970 5515-5522 VBD denotes induced
T5971 5523-5533 NN denotes regulation
T5972 5534-5536 IN denotes of
T5973 5537-5540 DT denotes the
T5974 5541-5550 JJ denotes Erk1-RSK1
T5975 5551-5561 NN denotes signalling
T5976 5562-5569 NN denotes pathway
T5977 5570-5573 VBD denotes was
T5978 5574-5581 VBN denotes reduced
T5979 5582-5584 IN denotes in
T5980 5585-5591 CD denotes PKD1/3
T5981 5591-5592 CD denotes −
T5982 5592-5593 NN denotes /
T5983 5593-5594 NN denotes −
T5984 5595-5596 NNP denotes B
T5985 5597-5602 NNS denotes cells
T5986 5603-5611 VBN denotes compared
T5987 5612-5614 TO denotes to
T5988 5615-5624 JJ denotes wild-type
T5989 5625-5626 NNP denotes B
T5990 5627-5632 NNS denotes cells
T5991 5633-5634 -LRB- denotes (
T5992 5634-5638 NNP denotes Fig.
T5993 5639-5641 NNP denotes 3B
T5994 5641-5642 -RRB- denotes )
T5995 5642-5643 . denotes .
T5996 5644-5647 CD denotes One
T5997 5648-5662 NN denotes interpretation
T5998 5663-5665 IN denotes of
T5999 5666-5670 DT denotes this
T6000 5671-5675 NN denotes data
T6001 5676-5678 VBZ denotes is
T6002 5679-5683 IN denotes that
T6003 5684-5687 NNP denotes PKD
T6004 5688-5695 VBZ denotes enzymes
T6005 5696-5699 MD denotes may
T6006 5700-5708 VB denotes modulate
T6007 5709-5712 NNP denotes Erk
T6008 5713-5723 NN denotes activation
T6009 5723-5724 . denotes .
T6010 5725-5731 RB denotes Indeed
T6011 5731-5732 , denotes ,
T6012 5733-5736 NNP denotes PKD
T6013 5737-5744 NNS denotes enzymes
T6014 5745-5749 VBP denotes have
T6015 5750-5760 RB denotes previously
T6016 5761-5765 VBN denotes been
T6017 5766-5772 VBN denotes linked
T6018 5773-5775 TO denotes to
T6019 5776-5779 DT denotes the
T6020 5780-5786 NN denotes growth
T6021 5787-5803 JJ denotes factor-regulated
T6022 5804-5807 NNP denotes Erk
T6023 5808-5818 NN denotes signalling
T6024 5819-5821 IN denotes in
T6025 5822-5832 NN denotes fibroblast
T6026 5833-5836 CC denotes and
T6027 5837-5848 JJ denotes endothelial
T6028 5849-5853 NN denotes cell
T6029 5854-5859 NNS denotes lines
T6030 5860-5861 NNP denotes [
T6031 5861-5863 CD denotes 33
T6032 5864-5866 CD denotes 35
T6033 5866-5867 NN denotes ]
T6034 5867-5868 . denotes .
T6035 5869-5876 RB denotes However
T6036 5876-5877 , denotes ,
T6037 5878-5889 JJ denotes BCR-induced
T6038 5890-5893 NNP denotes Erk
T6039 5894-5909 NN denotes phosphorylation
T6040 5910-5913 VBD denotes was
T6041 5914-5918 RB denotes also
T6042 5919-5926 VBN denotes reduced
T6043 5927-5929 IN denotes in
T6044 5930-5936 CD denotes PKD1/3
T6045 5936-5937 CD denotes −
T6046 5937-5938 NN denotes /
T6047 5938-5939 SYM denotes −
T6048 5939-5940 : denotes -
T6049 5940-5949 NN denotes Flag-PKD3
T6050 5949-5950 NN denotes +
T6051 5951-5952 NNP denotes B
T6052 5953-5958 NNS denotes cells
T6053 5959-5960 -LRB- denotes (
T6054 5960-5964 NNS denotes data
T6055 5965-5968 RB denotes not
T6056 5969-5974 VBN denotes shown
T6057 5974-5975 -RRB- denotes )
T6058 5976-5986 VBG denotes suggesting
T6059 5987-5991 IN denotes that
T6060 5992-5999 VBN denotes reduced
T6061 6000-6003 NNP denotes BCR
T6062 6004-6010 NNS denotes levels
T6063 6011-6013 IN denotes on
T6064 6014-6017 DT denotes the
T6065 6018-6025 NN denotes surface
T6066 6026-6028 IN denotes of
T6067 6029-6035 CD denotes PKD1/3
T6068 6035-6036 CD denotes −
T6069 6036-6037 NN denotes /
T6070 6037-6038 NN denotes −
T6071 6039-6040 -LRB- denotes (
T6072 6040-6043 CC denotes and
T6073 6044-6050 NNP denotes PKD1/3
T6074 6050-6051 VBD denotes −
T6075 6051-6052 CD denotes /
T6076 6052-6053 SYM denotes −
T6077 6053-6054 : denotes -
T6078 6054-6063 NN denotes Flag-PKD3
T6079 6063-6064 NN denotes +
T6080 6064-6065 -RRB- denotes )
T6081 6066-6067 NNP denotes B
T6082 6068-6073 NNS denotes cells
T6083 6074-6077 MD denotes may
T6084 6078-6084 PRP denotes itself
T6085 6085-6091 VB denotes impact
T6086 6092-6094 IN denotes on
T6087 6095-6098 DT denotes the
T6088 6099-6107 NN denotes strength
T6089 6108-6110 IN denotes of
T6090 6111-6121 NN denotes activation
T6091 6122-6124 IN denotes of
T6092 6125-6129 DT denotes this
T6093 6130-6138 JJ denotes specific
T6094 6139-6152 JJ denotes intracellular
T6095 6153-6163 NN denotes signalling
T6096 6164-6171 NN denotes pathway
T6097 6171-6172 . denotes .
T6098 6173-6175 TO denotes To
T6099 6176-6182 VB denotes search
T6100 6183-6186 IN denotes for
T6101 6187-6192 JJ denotes other
T6102 6193-6202 JJ denotes potential
T6103 6203-6206 NNP denotes PKD
T6104 6207-6214 NNS denotes targets
T6105 6215-6219 WDT denotes that
T6106 6220-6223 MD denotes may
T6107 6224-6228 VB denotes show
T6108 6229-6238 JJ denotes defective
T6109 6239-6249 NN denotes regulation
T6110 6250-6252 IN denotes in
T6111 6253-6259 NNP denotes PKD1/3
T6112 6259-6260 NNP denotes −
T6113 6260-6261 NNP denotes /
T6114 6261-6262 NNP denotes −
T6115 6263-6267 NNP denotes DT40
T6116 6268-6269 NNP denotes B
T6117 6270-6275 NNS denotes cells
T6118 6275-6276 , denotes ,
T6119 6277-6279 PRP denotes we
T6120 6280-6284 VBD denotes used
T6121 6285-6286 DT denotes a
T6122 6287-6290 NNP denotes PKD
T6123 6291-6300 VB denotes substrate
T6124 6301-6317 JJ denotes phospho-antibody
T6125 6318-6322 IN denotes that
T6126 6323-6333 VBZ denotes recognises
T6127 6334-6343 NN denotes consensus
T6128 6344-6359 NN denotes phosphorylation
T6129 6360-6369 NNS denotes sequences
T6130 6370-6378 VBN denotes targeted
T6131 6379-6381 IN denotes by
T6132 6382-6385 NNP denotes PKD
T6133 6386-6393 VBZ denotes enzymes
T6134 6394-6395 -LRB- denotes (
T6135 6395-6404 NNP denotes LxRxxpS/T
T6136 6404-6405 -RRB- denotes )
T6137 6406-6407 NNP denotes [
T6138 6407-6409 CD denotes 36
T6139 6409-6410 NNP denotes ]
T6140 6410-6411 . denotes .
T6141 6412-6414 IN denotes As
T6142 6415-6420 VBN denotes shown
T6143 6421-6423 IN denotes in
T6144 6424-6428 NNP denotes Fig.
T6145 6429-6431 NNP denotes 3C
T6146 6431-6432 , denotes ,
T6147 6433-6440 NN denotes phorbol
T6148 6441-6446 NN denotes ester
T6149 6446-6447 : denotes -
T6150 6448-6451 CC denotes and
T6151 6452-6463 JJ denotes BCR-induced
T6152 6464-6479 NN denotes phosphorylation
T6153 6480-6482 IN denotes of
T6154 6483-6491 JJ denotes cellular
T6155 6492-6502 NNS denotes substrates
T6156 6503-6511 VBN denotes detected
T6157 6512-6514 IN denotes by
T6158 6515-6519 DT denotes this
T6159 6520-6536 NN denotes phospho-antibody
T6160 6537-6540 VBD denotes was
T6161 6541-6548 JJ denotes similar
T6162 6549-6551 IN denotes in
T6163 6552-6561 JJ denotes wild-type
T6164 6562-6565 CC denotes and
T6165 6566-6572 JJ denotes PKD1/3
T6166 6572-6573 NN denotes −
T6167 6573-6574 NN denotes /
T6168 6574-6575 NN denotes −
T6169 6576-6581 NNS denotes cells
T6170 6582-6585 CC denotes and
T6171 6586-6588 VBZ denotes is
T6172 6589-6598 RB denotes therefore
T6173 6599-6610 JJ denotes independent
T6174 6611-6613 IN denotes of
T6175 6614-6617 NNP denotes PKD
T6176 6618-6625 VBZ denotes enzymes
T6177 6625-6626 . denotes .
T6178 6627-6634 RB denotes However
T6179 6634-6635 , denotes ,
T6180 6636-6648 NN denotes pretreatment
T6181 6649-6651 IN denotes of
T6182 6652-6656 DT denotes both
T6183 6657-6666 JJ denotes wild-type
T6184 6667-6670 CC denotes and
T6185 6671-6677 JJ denotes PKD1/3
T6186 6677-6678 NN denotes −
T6187 6678-6679 NN denotes /
T6188 6679-6680 NN denotes −
T6189 6681-6685 NNP denotes DT40
T6190 6686-6687 NNP denotes B
T6191 6688-6693 NNS denotes cells
T6192 6694-6698 IN denotes with
T6193 6699-6708 NNP denotes GF109203X
T6194 6708-6709 , denotes ,
T6195 6710-6711 DT denotes a
T6196 6712-6730 NN denotes bisindoylmaleimide
T6197 6731-6741 NN denotes derivative
T6198 6742-6746 WDT denotes that
T6199 6747-6755 VBZ denotes inhibits
T6200 6756-6760 NNS denotes PKCs
T6201 6761-6770 VBD denotes prevented
T6202 6771-6774 DT denotes the
T6203 6775-6784 NN denotes induction
T6204 6785-6787 IN denotes of
T6205 6788-6796 NNS denotes proteins
T6206 6797-6801 WDT denotes that
T6207 6802-6809 VBP denotes contain
T6208 6810-6824 VBN denotes phosphorylated
T6209 6825-6833 NNP denotes LxRxxS/T
T6210 6834-6840 NNS denotes motifs
T6211 6840-6841 . denotes .
T6212 6842-6846 RB denotes Thus
T6213 6847-6851 NN denotes loss
T6214 6852-6854 IN denotes of
T6215 6855-6861 NNP denotes PKD1/3
T6216 6862-6869 VBZ denotes enzymes
T6217 6870-6874 VBZ denotes does
T6218 6875-6878 RB denotes not
T6219 6879-6887 RB denotes globally
T6220 6888-6895 VB denotes disrupt
T6221 6896-6899 DT denotes the
T6222 6900-6915 NN denotes phosphorylation
T6223 6916-6918 IN denotes of
T6224 6919-6927 JJ denotes cellular
T6225 6928-6936 NNS denotes proteins
T6226 6937-6941 WDT denotes that
T6227 6942-6949 VBP denotes contain
T6228 6950-6959 NNP denotes LxRxxpS/T
T6229 6960-6966 NNS denotes motifs
T6230 6966-6967 . denotes .
T6231 6968-6972 DT denotes This
T6232 6973-6979 NN denotes result
T6233 6980-6982 VBZ denotes is
T6234 6983-6990 RB denotes perhaps
T6235 6991-6994 RB denotes not
T6236 6995-7005 JJ denotes surprising
T6237 7006-7008 IN denotes as
T6238 7009-7017 NNP denotes LxRxxS/T
T6239 7018-7024 NNS denotes motifs
T6240 7025-7029 RB denotes also
T6241 7030-7033 VBP denotes act
T6242 7034-7036 RB denotes as
T6243 7037-7041 JJ denotes good
T6244 7042-7052 NNS denotes substrates
T6245 7053-7056 IN denotes for
T6246 7057-7062 JJ denotes other
T6247 7063-7079 JJ denotes serine/threonine
T6248 7080-7087 NNS denotes kinases
T6249 7088-7092 JJ denotes such
T6250 7093-7095 IN denotes as
T6251 7096-7104 NNP denotes MAPKAPK2
T6252 7104-7105 . denotes .
T6253 7106-7113 RB denotes However
T6254 7114-7119 DT denotes these
T6255 7120-7131 NNS denotes experiments
T6256 7132-7134 VBP denotes do
T6257 7135-7142 VB denotes provide
T6258 7143-7150 JJ denotes further
T6259 7151-7159 NN denotes evidence
T6260 7160-7164 IN denotes that
T6261 7165-7180 JJ denotes phosphospecific
T6262 7181-7189 NN denotes antisera
T6263 7190-7193 VBP denotes are
T6264 7194-7197 RB denotes not
T6265 7198-7210 RB denotes sufficiently
T6266 7211-7220 JJ denotes selective
T6267 7221-7223 TO denotes to
T6268 7224-7226 VB denotes be
T6269 7227-7237 VBN denotes designated
T6270 7238-7244 NN denotes kinase
T6271 7245-7253 JJ denotes specific
T6272 7254-7263 JJ denotes substrate
T6273 7264-7272 NN denotes antisera
T6274 7272-7273 . denotes .
T6275 7274-7285 JJ denotes BCR-induced
T6276 7286-7296 JJ denotes signalling
T6277 7297-7305 NNS denotes pathways
T6278 7306-7315 VBP denotes culminate
T6279 7316-7318 IN denotes in
T6280 7319-7322 DT denotes the
T6281 7323-7333 NN denotes activation
T6282 7334-7336 IN denotes of
T6283 7337-7341 NN denotes gene
T6284 7342-7355 NN denotes transcription
T6285 7356-7362 NNS denotes events
T6286 7363-7367 WDT denotes that
T6287 7368-7375 VBP denotes control
T6288 7376-7377 NNP denotes B
T6289 7378-7382 NN denotes cell
T6290 7383-7391 NN denotes survival
T6291 7391-7392 , denotes ,
T6292 7393-7406 NN denotes proliferation
T6293 7407-7410 CC denotes and
T6294 7411-7419 NN denotes function
T6295 7419-7420 . denotes .
T6296 7421-7423 IN denotes In
T6297 7424-7428 DT denotes this
T6298 7429-7436 NN denotes context
T6299 7436-7437 , denotes ,
T6300 7438-7440 PRP denotes it
T6301 7441-7444 VBZ denotes has
T6302 7445-7449 VBN denotes been
T6303 7450-7458 VBN denotes proposed
T6304 7459-7463 IN denotes that
T6305 7464-7467 NNP denotes PKD
T6306 7468-7474 NN denotes family
T6307 7475-7482 NNS denotes members
T6308 7483-7490 NN denotes control
T6309 7491-7493 IN denotes of
T6310 7494-7498 NN denotes gene
T6311 7499-7512 NN denotes transcription
T6312 7513-7520 IN denotes through
T6313 7521-7531 NN denotes activation
T6314 7532-7534 IN denotes of
T6315 7535-7538 DT denotes the
T6316 7539-7543 NNP denotes NFκB
T6317 7544-7557 NN denotes transcription
T6318 7558-7564 NN denotes factor
T6319 7564-7565 . denotes .
T6320 7566-7570 RB denotes Thus
T6321 7570-7571 , denotes ,
T6322 7572-7584 JJ denotes PKD-mediated
T6323 7585-7595 NN denotes activation
T6324 7596-7598 IN denotes of
T6325 7599-7603 NNP denotes NFκB
T6326 7604-7610 VBZ denotes occurs
T6327 7611-7621 JJ denotes downstream
T6328 7622-7624 IN denotes of
T6329 7625-7626 DT denotes a
T6330 7627-7634 NN denotes variety
T6331 7635-7637 IN denotes of
T6332 7638-7647 JJ denotes different
T6333 7648-7655 NNS denotes signals
T6334 7655-7656 , denotes ,
T6335 7657-7666 VBG denotes including
T6336 7667-7681 JJ denotes mROS/oxidative
T6337 7682-7688 NN denotes stress
T6338 7688-7689 , denotes ,
T6339 7690-7706 JJ denotes lysophosphatidic
T6340 7707-7711 NN denotes acid
T6341 7712-7715 CC denotes and
T6342 7716-7719 DT denotes the
T6343 7720-7727 NNP denotes Bcr-Abl
T6344 7728-7736 NN denotes oncogene
T6345 7737-7738 NNP denotes [
T6346 7738-7752 CD denotes 17,21,23,30,37
T6347 7752-7753 NNP denotes ]
T6348 7753-7754 . denotes .
T6349 7755-7766 RB denotes Furthermore
T6350 7766-7767 , denotes ,
T6351 7768-7778 NN denotes expression
T6352 7779-7781 IN denotes of
T6353 7782-7784 DT denotes an
T6354 7785-7794 VBN denotes activated
T6355 7795-7799 NNP denotes PKD1
T6356 7800-7806 JJ denotes mutant
T6357 7807-7815 VBZ denotes enhances
T6358 7816-7829 JJ denotes HPK1-mediated
T6359 7830-7834 NNP denotes NFκB
T6360 7835-7845 NN denotes activation
T6361 7846-7847 NNP denotes [
T6362 7847-7849 CD denotes 38
T6363 7849-7850 NNP denotes ]
T6364 7850-7851 . denotes .
T6365 7852-7854 IN denotes In
T6366 7855-7856 NNP denotes B
T6367 7857-7862 NNS denotes cells
T6368 7862-7863 , denotes ,
T6369 7864-7868 NNP denotes NFκB
T6370 7869-7871 VBZ denotes is
T6371 7872-7877 VBN denotes known
T6372 7878-7880 TO denotes to
T6373 7881-7883 VB denotes be
T6374 7884-7893 VBN denotes regulated
T6375 7894-7897 IN denotes via
T6376 7898-7901 NNP denotes DAG
T6377 7902-7905 CC denotes and
T6378 7906-7910 NNP denotes PKCβ
T6379 7911-7912 NNP denotes [
T6380 7912-7917 CD denotes 39,40
T6381 7917-7918 NNP denotes ]
T6382 7919-7922 CC denotes but
T6383 7923-7930 IN denotes whether
T6384 7931-7935 NNS denotes PKDs
T6385 7936-7939 VBP denotes are
T6386 7940-7943 JJ denotes key
T6387 7944-7958 NNS denotes intermediaries
T6388 7959-7962 IN denotes for
T6389 7963-7967 NNP denotes NFκB
T6390 7968-7978 NN denotes regulation
T6391 7979-7982 VBZ denotes has
T6392 7983-7986 RB denotes not
T6393 7987-7991 VBN denotes been
T6394 7992-8000 VBN denotes explored
T6395 8000-8001 . denotes .
T6396 8002-8005 DT denotes The
T6397 8006-8010 NNS denotes data
T6398 8011-8012 -LRB- denotes (
T6399 8012-8016 NNP denotes Fig.
T6400 8017-8019 NNP denotes 4A
T6401 8019-8020 -RRB- denotes )
T6402 8021-8025 VBP denotes show
T6403 8026-8030 IN denotes that
T6404 8031-8035 NNP denotes NFκB
T6405 8036-8051 JJ denotes transcriptional
T6406 8052-8060 NN denotes activity
T6407 8061-8064 VBD denotes was
T6408 8065-8073 RB denotes strongly
T6409 8074-8081 VBN denotes induced
T6410 8082-8084 IN denotes in
T6411 8085-8089 DT denotes both
T6412 8090-8099 JJ denotes wild-type
T6413 8100-8103 CC denotes and
T6414 8104-8110 JJ denotes PKD1/3
T6415 8110-8111 NN denotes −
T6416 8111-8112 NN denotes /
T6417 8112-8113 NN denotes −
T6418 8114-8118 NNP denotes DT40
T6419 8119-8120 NNP denotes B
T6420 8121-8126 NNS denotes cells
T6421 8127-8129 IN denotes in
T6422 8130-8138 NN denotes response
T6423 8139-8141 TO denotes to
T6424 8142-8148 DT denotes either
T6425 8149-8156 NN denotes phorbol
T6426 8157-8162 NN denotes ester
T6427 8163-8165 CC denotes or
T6428 8166-8169 NNP denotes BCR
T6429 8170-8181 NN denotes stimulation
T6430 8181-8182 . denotes .
T6431 8183-8185 IN denotes In
T6432 8186-8194 NN denotes contrast
T6433 8194-8195 , denotes ,
T6434 8196-8199 NNP denotes BCR
T6435 8200-8203 CC denotes and
T6436 8204-8211 JJ denotes phorbol
T6437 8212-8225 JJ denotes ester-induced
T6438 8226-8230 NNP denotes NFκB
T6439 8231-8246 JJ denotes transcriptional
T6440 8247-8255 NN denotes activity
T6441 8256-8259 VBD denotes was
T6442 8260-8269 VBN denotes abolished
T6443 8270-8272 IN denotes in
T6444 8273-8277 NNP denotes PKCβ
T6445 8277-8278 NNP denotes −
T6446 8278-8279 NNP denotes /
T6447 8279-8280 NNP denotes −
T6448 8281-8285 NNP denotes DT40
T6449 8286-8287 NNP denotes B
T6450 8288-8293 NNS denotes cells
T6451 8294-8295 -LRB- denotes (
T6452 8295-8299 NNP denotes Fig.
T6453 8300-8302 NNP denotes 4A
T6454 8302-8303 -RRB- denotes )
T6455 8303-8304 , denotes ,
T6456 8305-8313 IN denotes although
T6457 8314-8320 JJ denotes strong
T6458 8321-8331 NN denotes activation
T6459 8332-8334 IN denotes of
T6460 8335-8338 NNP denotes PKD
T6461 8339-8346 NNS denotes kinases
T6462 8347-8348 -LRB- denotes (
T6463 8348-8350 IN denotes as
T6464 8351-8359 VBN denotes assessed
T6465 8360-8362 IN denotes by
T6466 8363-8382 NN denotes autophosphorylation
T6467 8383-8385 IN denotes of
T6468 8386-8390 NNP denotes PKD1
T6469 8391-8393 IN denotes at
T6470 8394-8398 NNP denotes S916
T6471 8398-8399 -RRB- denotes )
T6472 8400-8403 VBD denotes was
T6473 8404-8412 VBN denotes observed
T6474 8413-8415 IN denotes in
T6475 8416-8419 DT denotes the
T6476 8420-8424 NNP denotes PKCβ
T6477 8424-8425 NNP denotes −
T6478 8425-8426 VBD denotes /
T6479 8426-8427 CD denotes −
T6480 8428-8433 NNS denotes cells
T6481 8434-8435 -LRB- denotes (
T6482 8435-8439 NNP denotes Fig.
T6483 8440-8442 NNP denotes 4B
T6484 8442-8443 -RRB- denotes )
T6485 8443-8444 . denotes .
T6486 8445-8449 RB denotes Thus
T6487 8449-8450 , denotes ,
T6488 8451-8454 NNP denotes PKD
T6489 8455-8462 NNS denotes kinases
T6490 8463-8466 VBP denotes are
T6491 8467-8474 DT denotes neither
T6492 8475-8484 JJ denotes essential
T6493 8485-8488 CC denotes nor
T6494 8489-8499 JJ denotes sufficient
T6495 8500-8502 TO denotes to
T6496 8503-8510 VB denotes mediate
T6497 8511-8522 JJ denotes BCR-induced
T6498 8523-8527 NN denotes NFκB
T6499 8528-8538 NN denotes activation
T6500 8539-8541 IN denotes in
T6501 8542-8546 NNP denotes DT40
T6502 8547-8548 NNP denotes B
T6503 8549-8554 NNS denotes cells
T6504 8555-8558 CC denotes and
T6505 8559-8564 RB denotes hence
T6506 8565-8567 VBP denotes do
T6507 8568-8571 RB denotes not
T6508 8572-8583 VB denotes participate
T6509 8584-8586 IN denotes in
T6510 8587-8594 NNP denotes DAG/PKC
T6511 8595-8603 VBD denotes mediated
T6512 8604-8611 NN denotes control
T6513 8612-8614 IN denotes of
T6514 8615-8619 NNP denotes NFκB
T6515 8619-8620 . denotes .
R2280 T2731 T2744 nsubj Loss,kinases
R2281 T2732 T2731 prep of,Loss
R2282 T2733 T2734 compound HSP27,phosphorylation
R2283 T2734 T2732 pobj phosphorylation,of
R2284 T2735 T2731 prep in,Loss
R2285 T2736 T2737 compound DT40,B
R2286 T2737 T2738 compound B,cells
R2287 T2738 T2735 pobj cells,in
R2288 T2739 T2744 advcl lacking,kinases
R2289 T2740 T2739 dobj expression,lacking
R2290 T2741 T2740 prep of,expression
R2291 T2742 T2743 compound PKD,family
R2292 T2743 T2741 pobj family,of
R2293 T2744 T2744 ROOT kinases,kinases
R2294 T2745 T2746 compound DT40,B
R2295 T2746 T2747 compound B,cells
R2296 T2747 T2748 nsubj cells,express
R2297 T2748 T2744 ccomp express,kinases
R2298 T2749 T2751 nummod two,isoforms
R2299 T2750 T2751 compound PKD,isoforms
R2300 T2751 T2748 dobj isoforms,express
R2301 T2752 T2751 punct ",",isoforms
R2302 T2753 T2751 conj PKD1,isoforms
R2303 T2754 T2753 cc and,PKD1
R2304 T2755 T2753 conj PKD3,PKD1
R2305 T2756 T2755 punct ",",PKD3
R2306 T2757 T2748 cc and,express
R2307 T2758 T2760 mark as,described
R2308 T2759 T2760 advmod previously,described
R2309 T2760 T2764 advcl described,generated
R2310 T2761 T2764 nsubj we,generated
R2311 T2762 T2764 aux have,generated
R2312 T2763 T2764 advmod recently,generated
R2313 T2764 T2748 conj generated,express
R2314 T2765 T2768 compound DT40,lines
R2315 T2766 T2768 compound B,lines
R2316 T2767 T2768 compound cell,lines
R2317 T2768 T2764 dobj lines,generated
R2318 T2769 T2770 nsubj that,lack
R2319 T2770 T2768 relcl lack,lines
R2320 T2771 T2770 dobj expression,lack
R2321 T2772 T2771 prep of,expression
R2322 T2773 T2774 det either,PKD1
R2323 T2774 T2772 pobj PKD1,of
R2324 T2775 T2774 cc or,PKD1
R2325 T2776 T2774 conj PKD3,PKD1
R2326 T2777 T2776 cc or,PKD3
R2327 T2778 T2779 det both,enzymes
R2328 T2779 T2772 pobj enzymes,of
R2329 T2780 T2782 nmod [,]
R2330 T2781 T2782 nummod 1,]
R2331 T2782 T2764 npadvmod ],generated
R2332 T2783 T2744 punct .,kinases
R2333 T2784 T2800 prep In,/
R2334 T2785 T2784 pcomp generating,In
R2335 T2786 T2790 det the,lines
R2336 T2787 T2789 amod double,cell
R2337 T2788 T2789 compound knockout,cell
R2338 T2789 T2790 compound cell,lines
R2339 T2790 T2785 dobj lines,generating
R2340 T2791 T2792 nsubj we,targeted
R2341 T2792 T2790 relcl targeted,lines
R2342 T2793 T2795 det the,loci
R2343 T2794 T2795 compound PKD1,loci
R2344 T2795 T2792 dobj loci,targeted
R2345 T2796 T2792 prep in,targeted
R2346 T2797 T2799 det a,−
R2347 T2798 T2799 compound PKD3,−
R2348 T2799 T2796 pobj −,in
R2349 T2800 T2800 ROOT /,/
R2350 T2801 T2803 nummod −,line
R2351 T2802 T2803 compound cell,line
R2352 T2803 T2800 dobj line,/
R2353 T2804 T2805 nsubj that,expressed
R2354 T2805 T2803 relcl expressed,line
R2355 T2806 T2808 det a,transgene
R2356 T2807 T2808 amod Flag-PKD3,transgene
R2357 T2808 T2805 dobj transgene,expressed
R2358 T2809 T2808 prep under,transgene
R2359 T2810 T2811 det the,control
R2360 T2811 T2809 pobj control,under
R2361 T2812 T2811 prep of,control
R2362 T2813 T2815 det a,promoter
R2363 T2814 T2815 amod doxycycline-inducible,promoter
R2364 T2815 T2812 pobj promoter,of
R2365 T2816 T2800 punct .,/
R2366 T2817 T2832 advmod Hence,is
R2367 T2818 T2832 punct ",",is
R2368 T2819 T2826 nmod in,expression
R2369 T2820 T2821 det the,presence
R2370 T2821 T2819 pobj presence,in
R2371 T2822 T2821 prep of,presence
R2372 T2823 T2822 pobj doxycycline,of
R2373 T2824 T2821 punct ",",presence
R2374 T2825 T2826 compound Flag-PKD3,expression
R2375 T2826 T2832 nsubj expression,is
R2376 T2827 T2826 prep in,expression
R2377 T2828 T2831 nummod PKD1/3,cells
R2378 T2829 T2831 amod double,cells
R2379 T2830 T2831 compound knockout,cells
R2380 T2831 T2827 pobj cells,in
R2381 T2832 T2832 ROOT is,is
R2382 T2833 T2832 acomp comparable,is
R2383 T2834 T2833 prep to,comparable
R2384 T2835 T2837 amod endogenous,present
R2385 T2836 T2837 amod PKD3,present
R2386 T2837 T2834 pobj present,to
R2387 T2838 T2837 prep in,present
R2388 T2839 T2841 amod wild-type,cells
R2389 T2840 T2841 compound DT40,cells
R2390 T2841 T2838 pobj cells,in
R2391 T2842 T2837 cc and,present
R2392 T2843 T2837 conj removal,present
R2393 T2844 T2843 prep of,removal
R2394 T2845 T2844 pobj doxycycline,of
R2395 T2846 T2843 prep from,removal
R2396 T2847 T2849 det the,media
R2397 T2848 T2849 compound culture,media
R2398 T2849 T2846 pobj media,from
R2399 T2850 T2832 prep for,is
R2400 T2851 T2852 nummod 5,days
R2401 T2852 T2853 compound days,results
R2402 T2853 T2850 pobj results,for
R2403 T2854 T2853 prep in,results
R2404 T2855 T2859 det a,phenotype
R2405 T2856 T2857 advmod completely,null
R2406 T2857 T2859 amod null,phenotype
R2407 T2858 T2859 compound PKD,phenotype
R2408 T2859 T2854 pobj phenotype,in
R2409 T2860 T2862 punct (,1A
R2410 T2861 T2862 compound Fig.,1A
R2411 T2862 T2859 appos 1A,phenotype
R2412 T2863 T2862 punct ),1A
R2413 T2864 T2832 punct .,is
R2414 T2865 T2869 advmod Previously,demonstrated
R2415 T2866 T2869 punct ",",demonstrated
R2416 T2867 T2869 nsubj we,demonstrated
R2417 T2868 T2869 aux have,demonstrated
R2418 T2869 T2869 ROOT demonstrated,demonstrated
R2419 T2870 T2886 mark that,is
R2420 T2871 T2886 nsubj phosphorylation,is
R2421 T2872 T2871 cc and,phosphorylation
R2422 T2873 T2874 amod nuclear,exclusion
R2423 T2874 T2871 conj exclusion,phosphorylation
R2424 T2875 T2874 prep of,exclusion
R2425 T2876 T2879 nmod class,deacetylases
R2426 T2877 T2879 nmod II,deacetylases
R2427 T2878 T2879 compound histone,deacetylases
R2428 T2879 T2875 pobj deacetylases,of
R2429 T2880 T2879 punct (,deacetylases
R2430 T2881 T2879 appos HDACs,deacetylases
R2431 T2882 T2879 punct ),deacetylases
R2432 T2883 T2871 prep during,phosphorylation
R2433 T2884 T2885 compound BCR,engagement
R2434 T2885 T2883 pobj engagement,during
R2435 T2886 T2869 ccomp is,demonstrated
R2436 T2887 T2886 acomp defective,is
R2437 T2888 T2886 prep in,is
R2438 T2889 T2894 nummod PKD1/3,cells
R2439 T2890 T2894 nummod −,cells
R2440 T2891 T2894 nmod /,cells
R2441 T2892 T2894 compound −,cells
R2442 T2893 T2894 compound B,cells
R2443 T2894 T2888 pobj cells,in
R2444 T2895 T2886 cc and,is
R2445 T2896 T2897 aux can,restored
R2446 T2897 T2886 conj restored,is
R2447 T2898 T2897 prep upon,restored
R2448 T2899 T2898 pobj re-expression,upon
R2449 T2900 T2899 prep of,re-expression
R2450 T2901 T2904 det a,isoform
R2451 T2902 T2904 amod single,isoform
R2452 T2903 T2904 compound PKD,isoform
R2453 T2904 T2900 pobj isoform,of
R2454 T2905 T2907 nmod [,]
R2455 T2906 T2907 nummod 1,]
R2456 T2907 T2869 dobj ],demonstrated
R2457 T2908 T2869 punct .,demonstrated
R2458 T2909 T2913 det The,protein
R2459 T2910 T2913 amod small,protein
R2460 T2911 T2912 compound heat,shock
R2461 T2912 T2913 compound shock,protein
R2462 T2913 T2918 nsubj protein,proposed
R2463 T2914 T2913 appos HSP27,protein
R2464 T2915 T2918 aux has,proposed
R2465 T2916 T2918 advmod recently,proposed
R2466 T2917 T2918 auxpass been,proposed
R2467 T2918 T2918 ROOT proposed,proposed
R2468 T2919 T2918 prep as,proposed
R2469 T2920 T2922 det a,substrate
R2470 T2921 T2922 compound PKD1,substrate
R2471 T2922 T2919 pobj substrate,as
R2472 T2923 T2925 nmod [,]
R2473 T2924 T2925 nummod 24,]
R2474 T2925 T2922 dep ],substrate
R2475 T2926 T2922 cc and,substrate
R2476 T2927 T2929 nsubj we,assessed
R2477 T2928 T2929 advmod accordingly,assessed
R2478 T2929 T2922 conj assessed,substrate
R2479 T2930 T2934 mark whether,have
R2480 T2931 T2932 compound PKD-null,DT40
R2481 T2932 T2933 compound DT40,cells
R2482 T2933 T2934 nsubj cells,have
R2483 T2934 T2929 ccomp have,assessed
R2484 T2935 T2936 amod defective,phosphorylation
R2485 T2936 T2934 dobj phosphorylation,have
R2486 T2937 T2936 prep of,phosphorylation
R2487 T2938 T2937 pobj HSP27,of
R2488 T2939 T2936 prep on,phosphorylation
R2489 T2940 T2939 pobj serine,on
R2490 T2941 T2940 nummod 82,serine
R2491 T2942 T2936 punct ",",phosphorylation
R2492 T2943 T2947 det the,sequence
R2493 T2944 T2947 amod proposed,sequence
R2494 T2945 T2946 compound PKD1,substrate
R2495 T2946 T2947 compound substrate,sequence
R2496 T2947 T2936 appos sequence,phosphorylation
R2497 T2948 T2929 punct .,assessed
R2498 T2949 T2951 nsubj We,investigated
R2499 T2950 T2951 advmod initially,investigated
R2500 T2951 T2951 ROOT investigated,investigated
R2501 T2952 T2953 det the,regulation
R2502 T2953 T2951 dobj regulation,investigated
R2503 T2954 T2953 prep of,regulation
R2504 T2955 T2956 compound HSP27,phosphorylation
R2505 T2956 T2954 pobj phosphorylation,of
R2506 T2957 T2956 prep in,phosphorylation
R2507 T2958 T2959 amod single,knockout
R2508 T2959 T2962 compound knockout,cells
R2509 T2960 T2961 compound DT40,B
R2510 T2961 T2962 compound B,cells
R2511 T2962 T2957 pobj cells,in
R2512 T2963 T2951 advcl lacking,investigated
R2513 T2964 T2965 preconj either,PKD1
R2514 T2965 T2963 dobj PKD1,lacking
R2515 T2966 T2965 cc or,PKD1
R2516 T2967 T2965 conj PKD3,PKD1
R2517 T2968 T2951 punct .,investigated
R2518 T2969 T2970 mark As,shown
R2519 T2970 T2985 advcl shown,increased
R2520 T2971 T2970 prep in,shown
R2521 T2972 T2973 compound Fig.,1B
R2522 T2973 T2971 pobj 1B,in
R2523 T2974 T2973 punct ",",1B
R2524 T2975 T2973 appos activation,1B
R2525 T2976 T2975 prep of,activation
R2526 T2977 T2978 det the,BCR
R2527 T2978 T2976 pobj BCR,of
R2528 T2979 T2975 cc or,activation
R2529 T2980 T2975 conj treatment,activation
R2530 T2981 T2975 prep with,activation
R2531 T2982 T2984 det the,PdBu
R2532 T2983 T2984 compound DAG-mimetic,PdBu
R2533 T2984 T2981 pobj PdBu,with
R2534 T2985 T2985 ROOT increased,increased
R2535 T2986 T2987 det the,levels
R2536 T2987 T2985 dobj levels,increased
R2537 T2988 T2987 prep of,levels
R2538 T2989 T2990 compound HSP27,phosphorylation
R2539 T2990 T2988 pobj phosphorylation,of
R2540 T2991 T2987 prep at,levels
R2541 T2992 T2991 pobj S82,at
R2542 T2993 T2992 prep in,S82
R2543 T2994 T2997 amod wild-type,cells
R2544 T2995 T2996 compound DT40,B
R2545 T2996 T2997 compound B,cells
R2546 T2997 T2993 pobj cells,in
R2547 T2998 T2985 punct .,increased
R2548 T2999 T3004 nsubj BCR,were
R2549 T3000 T2999 cc and,BCR
R2550 T3001 T3003 amod phorbol,signals
R2551 T3002 T3003 compound ester,signals
R2552 T3003 T2999 conj signals,BCR
R2553 T3004 T3004 ROOT were,were
R2554 T3005 T3004 advmod also,were
R2555 T3006 T3004 acomp able,were
R2556 T3007 T3008 aux to,increase
R2557 T3008 T3006 xcomp increase,able
R2558 T3009 T3010 compound HSP27,phosphorylation
R2559 T3010 T3008 dobj phosphorylation,increase
R2560 T3011 T3008 prep in,increase
R2561 T3012 T3016 nummod PKD1,knockout
R2562 T3013 T3012 cc or,PKD1
R2563 T3014 T3012 conj PKD3,PKD1
R2564 T3015 T3016 amod single,knockout
R2565 T3016 T3019 compound knockout,cells
R2566 T3017 T3018 compound DT40,B
R2567 T3018 T3019 compound B,cells
R2568 T3019 T3011 pobj cells,in
R2569 T3020 T3004 punct (,were
R2570 T3021 T3022 compound Fig.,1B
R2571 T3022 T3004 npadvmod 1B,were
R2572 T3023 T3004 punct ),were
R2573 T3024 T3004 punct .,were
R2574 T3025 T3038 advmod However,abolished
R2575 T3026 T3038 punct ",",abolished
R2576 T3027 T3038 nsubjpass BCR,abolished
R2577 T3028 T3027 punct -,BCR
R2578 T3029 T3027 cc and,BCR
R2579 T3030 T3032 nmod phorbol,phosphorylation
R2580 T3031 T3032 amod ester-induced,phosphorylation
R2581 T3032 T3027 conj phosphorylation,BCR
R2582 T3033 T3032 prep of,phosphorylation
R2583 T3034 T3033 pobj HSP27,of
R2584 T3035 T3032 prep on,phosphorylation
R2585 T3036 T3035 pobj S82,on
R2586 T3037 T3038 auxpass was,abolished
R2587 T3038 T3038 ROOT abolished,abolished
R2588 T3039 T3038 prep in,abolished
R2589 T3040 T3041 compound B,cells
R2590 T3041 T3039 pobj cells,in
R2591 T3042 T3043 nsubj that,lacked
R2592 T3043 T3041 relcl lacked,cells
R2593 T3044 T3045 preconj both,PKD1
R2594 T3045 T3043 dobj PKD1,lacked
R2595 T3046 T3045 cc and,PKD1
R2596 T3047 T3045 conj PKD3,PKD1
R2597 T3048 T3047 punct (,PKD3
R2598 T3049 T3050 compound Fig.,1C
R2599 T3050 T3047 appos 1C,PKD3
R2600 T3051 T3047 punct ),PKD3
R2601 T3052 T3038 punct .,abolished
R2602 T3053 T3066 advmod Significantly,was
R2603 T3054 T3056 punct ",",expression
R2604 T3055 T3056 amod doxycycline-induced,expression
R2605 T3056 T3066 nsubj expression,was
R2606 T3057 T3056 prep of,expression
R2607 T3058 T3060 det the,transgene
R2608 T3059 T3060 compound Flag-PKD3,transgene
R2609 T3060 T3057 pobj transgene,of
R2610 T3061 T3060 prep in,transgene
R2611 T3062 T3065 det the,cells
R2612 T3063 T3065 amod double,cells
R2613 T3064 T3065 compound knockout,cells
R2614 T3065 T3061 pobj cells,in
R2615 T3066 T3066 ROOT was,was
R2616 T3067 T3066 acomp sufficient,was
R2617 T3068 T3069 aux to,restore
R2618 T3069 T3067 xcomp restore,sufficient
R2619 T3070 T3071 amod normal,regulation
R2620 T3071 T3069 dobj regulation,restore
R2621 T3072 T3071 prep of,regulation
R2622 T3073 T3074 compound HSP27,phosphorylation
R2623 T3074 T3072 pobj phosphorylation,of
R2624 T3075 T3077 punct (,1C
R2625 T3076 T3077 compound Fig.,1C
R2626 T3077 T3074 appos 1C,phosphorylation
R2627 T3078 T3077 punct ),1C
R2628 T3079 T3066 punct .,was
R2629 T3080 T3095 prep In,was
R2630 T3081 T3080 pobj contrast,In
R2631 T3082 T3095 punct ",",was
R2632 T3083 T3095 nsubj expression,was
R2633 T3084 T3083 prep of,expression
R2634 T3085 T3089 det a,protein
R2635 T3086 T3089 amod kinase-deficient,protein
R2636 T3087 T3089 amod PKD3,protein
R2637 T3088 T3089 amod mutant,protein
R2638 T3089 T3084 pobj protein,of
R2639 T3090 T3089 prep in,protein
R2640 T3091 T3094 det the,cells
R2641 T3092 T3094 amod double,cells
R2642 T3093 T3094 compound knockout,cells
R2643 T3094 T3090 pobj cells,in
R2644 T3095 T3095 ROOT was,was
R2645 T3096 T3095 neg not,was
R2646 T3097 T3095 acomp able,was
R2647 T3098 T3099 aux to,restore
R2648 T3099 T3097 xcomp restore,able
R2649 T3100 T3099 dobj BCR,restore
R2650 T3101 T3100 punct -,BCR
R2651 T3102 T3099 cc or,restore
R2652 T3103 T3099 conj phorbol,restore
R2653 T3104 T3106 amod ester-induced,phosphorylation
R2654 T3105 T3106 compound HSP27,phosphorylation
R2655 T3106 T3103 dobj phosphorylation,phorbol
R2656 T3107 T3106 punct (,phosphorylation
R2657 T3108 T3109 compound Fig.,1D
R2658 T3109 T3106 appos 1D,phosphorylation
R2659 T3110 T3106 punct ),phosphorylation
R2660 T3111 T3095 punct .,was
R2661 T3112 T3120 advmod Hence,regulate
R2662 T3113 T3120 punct ",",regulate
R2663 T3114 T3120 nsubj PKD3,regulate
R2664 T3115 T3117 advmod as,as
R2665 T3116 T3117 advmod well,as
R2666 T3117 T3114 cc as,PKD3
R2667 T3118 T3114 conj PKD1,PKD3
R2668 T3119 T3120 aux can,regulate
R2669 T3120 T3120 ROOT regulate,regulate
R2670 T3121 T3122 compound HSP27,phosphorylation
R2671 T3122 T3120 dobj phosphorylation,regulate
R2672 T3123 T3120 cc and,regulate
R2673 T3124 T3120 prep in,regulate
R2674 T3125 T3126 compound DT40,B
R2675 T3126 T3127 compound B,cells
R2676 T3127 T3124 pobj cells,in
R2677 T3128 T3129 nsubj they,are
R2678 T3129 T3120 conj are,regulate
R2679 T3130 T3131 advmod functionally,redundant
R2680 T3131 T3129 acomp redundant,are
R2681 T3132 T3131 prep as,redundant
R2682 T3133 T3134 compound HSP27,kinases
R2683 T3134 T3132 pobj kinases,as
R2684 T3135 T3129 punct .,are
R3417 T4218 T4219 compound Cellular,proliferation
R3418 T4219 T4231 nsubj proliferation,kinases
R3419 T4220 T4219 cc and,proliferation
R3420 T4221 T4219 conj survival,proliferation
R3421 T4222 T4219 prep in,proliferation
R3422 T4223 T4224 compound DT40,B
R3423 T4224 T4225 compound B,cells
R3424 T4225 T4222 pobj cells,in
R3425 T4226 T4231 advcl lacking,kinases
R3426 T4227 T4226 dobj expression,lacking
R3427 T4228 T4227 prep of,expression
R3428 T4229 T4230 compound PKD,family
R3429 T4230 T4228 pobj family,of
R3430 T4231 T4231 ROOT kinases,kinases
R3431 T4232 T4233 compound PKD,enzymes
R3432 T4233 T4237 nsubjpass enzymes,linked
R3433 T4234 T4237 aux have,linked
R3434 T4235 T4237 advmod previously,linked
R3435 T4236 T4237 auxpass been,linked
R3436 T4237 T4231 ccomp linked,kinases
R3437 T4238 T4237 prep to,linked
R3438 T4239 T4240 det the,regulation
R3439 T4240 T4238 pobj regulation,to
R3440 T4241 T4240 prep of,regulation
R3441 T4242 T4243 compound cell,proliferation
R3442 T4243 T4241 pobj proliferation,of
R3443 T4244 T4243 cc and,proliferation
R3444 T4245 T4243 conj survival,proliferation
R3445 T4246 T4243 punct (,proliferation
R3446 T4247 T4240 acl reviewed,regulation
R3447 T4248 T4247 prep in,reviewed
R3448 T4249 T4248 pobj [,in
R3449 T4250 T4251 nummod 20,]
R3450 T4251 T4249 appos ],[
R3451 T4252 T4249 punct ),[
R3452 T4253 T4231 punct .,kinases
R3453 T4254 T4255 aux To,investigate
R3454 T4255 T4271 advcl investigate,cultured
R3455 T4256 T4257 det the,effect
R3456 T4257 T4255 dobj effect,investigate
R3457 T4258 T4263 dobj that,had
R3458 T4259 T4263 nsubj loss,had
R3459 T4260 T4259 prep of,loss
R3460 T4261 T4262 compound PKD,kinases
R3461 T4262 T4260 pobj kinases,of
R3462 T4263 T4257 relcl had,effect
R3463 T4264 T4263 prep on,had
R3464 T4265 T4267 compound B,survival
R3465 T4266 T4267 compound cell,survival
R3466 T4267 T4264 pobj survival,on
R3467 T4268 T4263 cc and/or,had
R3468 T4269 T4271 dobj proliferation,cultured
R3469 T4270 T4271 nsubj we,cultured
R3470 T4271 T4271 ROOT cultured,cultured
R3471 T4272 T4275 amod wild-type,cells
R3472 T4273 T4272 cc and,wild-type
R3473 T4274 T4272 conj PKD-null,wild-type
R3474 T4275 T4271 dobj cells,cultured
R3475 T4276 T4271 prep in,cultured
R3476 T4277 T4278 det the,presence
R3477 T4278 T4276 pobj presence,in
R3478 T4279 T4278 punct (,presence
R3479 T4280 T4300 nsubj PKD1/3,monitored
R3480 T4281 T4283 nummod −,−
R3481 T4282 T4283 compound /,−
R3482 T4283 T4300 dep −,monitored
R3483 T4284 T4283 punct :,−
R3484 T4285 T4287 nmod Flag-PKD3,ve
R3485 T4286 T4287 compound +,ve
R3486 T4287 T4283 appos ve,−
R3487 T4288 T4287 punct ),ve
R3488 T4289 T4287 cc or,ve
R3489 T4290 T4287 conj absence,ve
R3490 T4291 T4290 punct (,absence
R3491 T4292 T4295 nummod PKD1/3,−
R3492 T4293 T4295 nummod −,−
R3493 T4294 T4295 compound /,−
R3494 T4295 T4290 appos −,absence
R3495 T4296 T4295 punct ),−
R3496 T4297 T4290 prep of,absence
R3497 T4298 T4297 pobj doxycycline,of
R3498 T4299 T4290 cc and,absence
R3499 T4300 T4271 advcl monitored,cultured
R3500 T4301 T4302 amod exponential,growth
R3501 T4302 T4300 dobj growth,monitored
R3502 T4303 T4271 punct .,cultured
R3503 T4304 T4305 mark As,shown
R3504 T4305 T4311 advcl shown,−
R3505 T4306 T4305 prep in,shown
R3506 T4307 T4308 compound Fig.,2A
R3507 T4308 T4306 pobj 2A,in
R3508 T4309 T4311 punct ",",−
R3509 T4310 T4311 nsubj PKD1/3,−
R3510 T4311 T4311 ROOT −,−
R3511 T4312 T4314 nummod /,cells
R3512 T4313 T4314 compound −,cells
R3513 T4314 T4315 nsubj cells,proliferated
R3514 T4315 T4311 ccomp proliferated,−
R3515 T4316 T4315 advmod exponentially,proliferated
R3516 T4317 T4315 cc and,proliferated
R3517 T4318 T4324 nsubj re-expression,had
R3518 T4319 T4318 prep of,re-expression
R3519 T4320 T4319 pobj Flag-PKD3,of
R3520 T4321 T4318 prep in,re-expression
R3521 T4322 T4323 det these,cells
R3522 T4323 T4321 pobj cells,in
R3523 T4324 T4315 conj had,proliferated
R3524 T4325 T4326 det no,impact
R3525 T4326 T4324 dobj impact,had
R3526 T4327 T4326 prep on,impact
R3527 T4328 T4329 det the,rate
R3528 T4329 T4327 pobj rate,on
R3529 T4330 T4329 prep of,rate
R3530 T4331 T4330 pobj proliferation,of
R3531 T4332 T4311 punct .,−
R3532 T4333 T4347 advmod Furthermore,was
R3533 T4334 T4347 punct ",",was
R3534 T4335 T4336 det the,viability
R3535 T4336 T4347 nsubj viability,was
R3536 T4337 T4336 prep of,viability
R3537 T4338 T4343 nummod PKD1/3,cells
R3538 T4339 T4343 nummod −,cells
R3539 T4340 T4343 compound /,cells
R3540 T4341 T4343 compound −,cells
R3541 T4342 T4343 compound B,cells
R3542 T4343 T4337 pobj cells,of
R3543 T4344 T4336 prep during,viability
R3544 T4345 T4346 amod routine,culturing
R3545 T4346 T4344 pobj culturing,during
R3546 T4347 T4347 ROOT was,was
R3547 T4348 T4347 neg not,was
R3548 T4349 T4350 advmod significantly,different
R3549 T4350 T4347 acomp different,was
R3550 T4351 T4350 prep from,different
R3551 T4352 T4351 pobj that,from
R3552 T4353 T4352 prep of,that
R3553 T4354 T4356 amod wild-type,cells
R3554 T4355 T4356 compound B,cells
R3555 T4356 T4353 pobj cells,of
R3556 T4357 T4360 punct (,shown
R3557 T4358 T4360 nsubjpass data,shown
R3558 T4359 T4360 neg not,shown
R3559 T4360 T4347 conj shown,was
R3560 T4361 T4360 punct ),shown
R3561 T4362 T4347 punct .,was
R3562 T4363 T4365 nsubjpass It,noted
R3563 T4364 T4365 auxpass was,noted
R3564 T4365 T4365 ROOT noted,noted
R3565 T4366 T4377 mark that,was
R3566 T4367 T4370 det the,time
R3567 T4368 T4369 compound population,doubling
R3568 T4369 T4370 amod doubling,time
R3569 T4370 T4377 nsubj time,was
R3570 T4371 T4370 prep of,time
R3571 T4372 T4376 nummod PKD1/3,cells
R3572 T4373 T4376 nummod −,cells
R3573 T4374 T4376 compound /,cells
R3574 T4375 T4376 compound −,cells
R3575 T4376 T4371 pobj cells,of
R3576 T4377 T4365 ccomp was,noted
R3577 T4378 T4379 advmod slightly,slower
R3578 T4379 T4377 acomp slower,was
R3579 T4380 T4379 prep than,slower
R3580 T4381 T4380 pobj that,than
R3581 T4382 T4381 prep of,that
R3582 T4383 T4384 amod wild,type
R3583 T4384 T4382 pobj type,of
R3584 T4385 T4386 nummod DT40,cells
R3585 T4386 T4384 appos cells,type
R3586 T4387 T4386 punct (,cells
R3587 T4388 T4391 nummod 12.7,h
R3588 T4389 T4391 nmod ±,h
R3589 T4390 T4391 nummod 2.8,h
R3590 T4391 T4386 appos h,cells
R3591 T4392 T4391 prep versus,h
R3592 T4393 T4396 nummod 10.2,h
R3593 T4394 T4396 nmod ±,h
R3594 T4395 T4396 nummod 0.4,h
R3595 T4396 T4392 pobj h,versus
R3596 T4397 T4386 punct ),cells
R3597 T4398 T4365 cc but,noted
R3598 T4399 T4400 det the,failure
R3599 T4400 T4415 nsubj failure,suggests
R3600 T4401 T4400 prep of,failure
R3601 T4402 T4403 nummod PKD3,re-expression
R3602 T4403 T4401 pobj re-expression,of
R3603 T4404 T4405 aux to,modify
R3604 T4405 T4400 acl modify,failure
R3605 T4406 T4408 det the,rate
R3606 T4407 T4408 compound proliferation,rate
R3607 T4408 T4405 dobj rate,modify
R3608 T4409 T4408 prep of,rate
R3609 T4410 T4414 nummod PKD1/3,cells
R3610 T4411 T4414 nummod −,cells
R3611 T4412 T4414 compound /,cells
R3612 T4413 T4414 compound −,cells
R3613 T4414 T4409 pobj cells,of
R3614 T4415 T4365 conj suggests,noted
R3615 T4416 T4420 mark that,were
R3616 T4417 T4419 det these,differences
R3617 T4418 T4419 amod small,differences
R3618 T4419 T4420 nsubj differences,were
R3619 T4420 T4415 ccomp were,suggests
R3620 T4421 T4422 advmod most,likely
R3621 T4422 T4420 acomp likely,were
R3622 T4423 T4424 det the,result
R3623 T4424 T4420 attr result,were
R3624 T4425 T4424 prep of,result
R3625 T4426 T4427 amod clonal,variation
R3626 T4427 T4425 pobj variation,of
R3627 T4428 T4420 cc and,were
R3628 T4429 T4431 auxpass were,caused
R3629 T4430 T4431 neg not,caused
R3630 T4431 T4420 conj caused,were
R3631 T4432 T4431 advmod specifically,caused
R3632 T4433 T4431 agent by,caused
R3633 T4434 T4433 pobj loss,by
R3634 T4435 T4434 prep of,loss
R3635 T4436 T4437 compound PKD,enzymes
R3636 T4437 T4435 pobj enzymes,of
R3637 T4438 T4415 punct .,suggests
R3638 T4439 T4444 advmod Thus,are
R3639 T4440 T4444 punct ",",are
R3640 T4441 T4443 compound PKD,enzymes
R3641 T4442 T4443 compound family,enzymes
R3642 T4443 T4444 nsubj enzymes,are
R3643 T4444 T4444 ROOT are,are
R3644 T4445 T4444 neg not,are
R3645 T4446 T4444 acomp essential,are
R3646 T4447 T4446 prep for,essential
R3647 T4448 T4447 pcomp regulating,for
R3648 T4449 T4450 amod basal,survival
R3649 T4450 T4448 dobj survival,regulating
R3650 T4451 T4450 cc and,survival
R3651 T4452 T4450 conj proliferation,survival
R3652 T4453 T4452 prep of,proliferation
R3653 T4454 T4455 compound DT40,B
R3654 T4455 T4456 compound B,cells
R3655 T4456 T4453 pobj cells,of
R3656 T4457 T4444 punct .,are
R3657 T4458 T4459 compound PKD,enzymes
R3658 T4459 T4469 nsubj enzymes,linked
R3659 T4460 T4459 punct ",",enzymes
R3660 T4461 T4462 advmod specifically,PKD1
R3661 T4462 T4459 appos PKD1,enzymes
R3662 T4463 T4462 cc and,PKD1
R3663 T4464 T4462 conj PKD2,PKD1
R3664 T4465 T4469 punct ",",linked
R3665 T4466 T4469 aux have,linked
R3666 T4467 T4469 advmod previously,linked
R3667 T4468 T4469 auxpass been,linked
R3668 T4469 T4469 ROOT linked,linked
R3669 T4470 T4469 prep to,linked
R3670 T4471 T4473 det a,role
R3671 T4472 T4473 amod protective,role
R3672 T4473 T4470 pobj role,to
R3673 T4474 T4473 prep against,role
R3674 T4475 T4477 amod oxidative,injury
R3675 T4476 T4477 amod stress-induced,injury
R3676 T4477 T4486 nmod injury,lines
R3677 T4478 T4477 prep in,injury
R3678 T4479 T4480 compound 3T3,fibroblast
R3679 T4480 T4478 pobj fibroblast,in
R3680 T4481 T4480 punct ",",fibroblast
R3681 T4482 T4480 conj HeLa,fibroblast
R3682 T4483 T4482 cc and,HeLa
R3683 T4484 T4486 amod epithelial,lines
R3684 T4485 T4486 compound cell,lines
R3685 T4486 T4474 pobj lines,against
R3686 T4487 T4488 compound [,"17,30"
R3687 T4488 T4486 appos "17,30",lines
R3688 T4489 T4490 nummod 32,]
R3689 T4490 T4486 appos ],lines
R3690 T4491 T4469 punct .,linked
R3691 T4492 T4494 nsubj We,addressed
R3692 T4493 T4494 advmod therefore,addressed
R3693 T4494 T4494 ROOT addressed,addressed
R3694 T4495 T4496 det the,role
R3695 T4496 T4494 dobj role,addressed
R3696 T4497 T4496 prep of,role
R3697 T4498 T4499 compound PKD,family
R3698 T4499 T4500 compound family,kinases
R3699 T4500 T4497 pobj kinases,of
R3700 T4501 T4496 prep in,role
R3701 T4502 T4501 pcomp regulating,in
R3702 T4503 T4504 compound B,cell
R3703 T4504 T4505 compound cell,survival
R3704 T4505 T4502 dobj survival,regulating
R3705 T4506 T4502 prep in,regulating
R3706 T4507 T4506 pobj response,in
R3707 T4508 T4507 prep to,response
R3708 T4509 T4510 amod oxidative,stress
R3709 T4510 T4508 pobj stress,to
R3710 T4511 T4510 cc and,stress
R3711 T4512 T4514 amod other,stimuli
R3712 T4513 T4514 compound stress,stimuli
R3713 T4514 T4510 conj stimuli,stress
R3714 T4515 T4494 punct .,addressed
R3715 T4516 T4517 mark As,shown
R3716 T4517 T4526 advcl shown,had
R3717 T4518 T4517 prep in,shown
R3718 T4519 T4520 compound Fig.,2B
R3719 T4520 T4518 pobj 2B,in
R3720 T4521 T4520 punct ",",2B
R3721 T4522 T4520 appos loss,2B
R3722 T4523 T4522 prep of,loss
R3723 T4524 T4525 nummod PKD1/3,expression
R3724 T4525 T4523 pobj expression,of
R3725 T4526 T4526 ROOT had,had
R3726 T4527 T4529 det no,impact
R3727 T4528 T4529 amod significant,impact
R3728 T4529 T4526 dobj impact,had
R3729 T4530 T4529 prep on,impact
R3730 T4531 T4532 det the,survival
R3731 T4532 T4530 pobj survival,on
R3732 T4533 T4532 prep of,survival
R3733 T4534 T4535 compound DT40,B
R3734 T4535 T4536 compound B,cells
R3735 T4536 T4533 pobj cells,of
R3736 T4537 T4526 prep in,had
R3737 T4538 T4537 pobj response,in
R3738 T4539 T4538 prep to,response
R3739 T4540 T4542 amod mitochondrial,stimuli
R3740 T4541 T4542 compound stress,stimuli
R3741 T4542 T4539 pobj stimuli,to
R3742 T4543 T4542 punct (,stimuli
R3743 T4544 T4542 appos H2O2,stimuli
R3744 T4545 T4544 cc or,H2O2
R3745 T4546 T4547 compound serum,deprivation
R3746 T4547 T4544 conj deprivation,H2O2
R3747 T4548 T4542 punct ),stimuli
R3748 T4549 T4542 punct ;,stimuli
R3749 T4550 T4552 amod DNA,agents
R3750 T4551 T4552 amod damaging,agents
R3751 T4552 T4542 conj agents,stimuli
R3752 T4553 T4552 punct (,agents
R3753 T4554 T4552 appos etoposide,agents
R3754 T4555 T4554 cc or,etoposide
R3755 T4556 T4554 conj doxorubicin,etoposide
R3756 T4557 T4552 punct ),agents
R3757 T4558 T4526 punct ;,had
R3758 T4559 T4561 compound ER,stress
R3759 T4560 T4561 compound pathway,stress
R3760 T4561 T4570 nsubj stress,following
R3761 T4562 T4561 amod due,stress
R3762 T4563 T4562 pcomp to,due
R3763 T4564 T4565 compound calcium,overload
R3764 T4565 T4562 pobj overload,due
R3765 T4566 T4567 punct (,thapsigargin
R3766 T4567 T4565 appos thapsigargin,overload
R3767 T4568 T4567 punct ),thapsigargin
R3768 T4569 T4565 cc or,overload
R3769 T4570 T4526 advcl following,had
R3770 T4571 T4572 amod prolonged,treatment
R3771 T4572 T4570 dobj treatment,following
R3772 T4573 T4572 prep with,treatment
R3773 T4574 T4575 compound phorbol,esters
R3774 T4575 T4573 pobj esters,with
R3775 T4576 T4575 cc or,esters
R3776 T4577 T4578 compound Trichostatin,A
R3777 T4578 T4575 conj A,esters
R3778 T4579 T4578 punct ",",A
R3779 T4580 T4581 det an,inhibitor
R3780 T4581 T4578 appos inhibitor,A
R3781 T4582 T4581 prep of,inhibitor
R3782 T4583 T4585 compound class,HDACs
R3783 T4584 T4585 compound I/II,HDACs
R3784 T4585 T4582 pobj HDACs,of
R3785 T4586 T4526 punct .,had
R3786 T4587 T4593 advmod Thus,play
R3787 T4588 T4593 punct ",",play
R3788 T4589 T4590 compound PKD,kinases
R3789 T4590 T4593 nsubj kinases,play
R3790 T4591 T4593 aux do,play
R3791 T4592 T4593 neg not,play
R3792 T4593 T4593 ROOT play,play
R3793 T4594 T4596 det an,role
R3794 T4595 T4596 amod essential,role
R3795 T4596 T4593 dobj role,play
R3796 T4597 T4593 prep in,play
R3797 T4598 T4597 pcomp regulating,in
R3798 T4599 T4600 compound B,cell
R3799 T4600 T4601 compound cell,survival
R3800 T4601 T4598 dobj survival,regulating
R3801 T4602 T4598 prep in,regulating
R3802 T4603 T4602 pobj response,in
R3803 T4604 T4603 prep to,response
R3804 T4605 T4606 det a,range
R3805 T4606 T4604 pobj range,to
R3806 T4607 T4606 prep of,range
R3807 T4608 T4610 amod different,stimuli
R3808 T4609 T4610 compound stress,stimuli
R3809 T4610 T4607 pobj stimuli,of
R3810 T4611 T4593 punct .,play
R4622 T5769 T5770 compound Antigen,receptor
R4623 T5770 T5773 amod receptor,pathways
R4624 T5771 T5773 amod regulated,pathways
R4625 T5772 T5773 amod signalling,pathways
R4626 T5773 T5781 nsubj pathways,explore
R4627 T5774 T5773 prep in,pathways
R4628 T5775 T5777 compound PKD-null,B
R4629 T5776 T5777 compound DT40,B
R4630 T5777 T5778 compound B,cells
R4631 T5778 T5774 pobj cells,in
R4632 T5779 T5781 aux To,explore
R4633 T5780 T5781 advmod further,explore
R4634 T5781 T5781 ROOT explore,explore
R4635 T5782 T5783 det the,contribution
R4636 T5783 T5781 dobj contribution,explore
R4637 T5784 T5783 prep of,contribution
R4638 T5785 T5786 compound PKD,kinases
R4639 T5786 T5784 pobj kinases,of
R4640 T5787 T5786 prep to,kinases
R4641 T5788 T5791 compound DT40,biology
R4642 T5789 T5791 compound B,biology
R4643 T5790 T5791 compound cell,biology
R4644 T5791 T5787 pobj biology,to
R4645 T5792 T5793 nsubj we,investigated
R4646 T5793 T5783 relcl investigated,contribution
R4647 T5794 T5799 mark whether,were
R4648 T5795 T5798 amod specific,events
R4649 T5796 T5798 amod BCR-regulated,events
R4650 T5797 T5798 amod signalling,events
R4651 T5798 T5799 nsubj events,were
R4652 T5799 T5793 ccomp were,investigated
R4653 T5800 T5799 acomp defective,were
R4654 T5801 T5800 prep in,defective
R4655 T5802 T5805 det the,cells
R4656 T5803 T5804 compound PKD-null,B
R4657 T5804 T5805 compound B,cells
R4658 T5805 T5801 pobj cells,in
R4659 T5806 T5781 punct .,explore
R4660 T5807 T5808 amod Initial,experiments
R4661 T5808 T5809 nsubj experiments,revealed
R4662 T5809 T5809 ROOT revealed,revealed
R4663 T5810 T5817 mark that,reduced
R4664 T5811 T5812 compound surface,expression
R4665 T5812 T5817 nsubjpass expression,reduced
R4666 T5813 T5812 prep of,expression
R4667 T5814 T5815 det the,BCR
R4668 T5815 T5813 pobj BCR,of
R4669 T5816 T5817 auxpass was,reduced
R4670 T5817 T5809 ccomp reduced,revealed
R4671 T5818 T5817 prep in,reduced
R4672 T5819 T5822 nummod PKD1/3,−
R4673 T5820 T5822 nummod −,−
R4674 T5821 T5822 compound /,−
R4675 T5822 T5818 pobj −,in
R4676 T5823 T5822 punct (,−
R4677 T5824 T5818 cc and,in
R4678 T5825 T5817 prep in,reduced
R4679 T5826 T5835 nummod PKD1/3,cells
R4680 T5827 T5829 nummod −,−
R4681 T5828 T5829 compound /,−
R4682 T5829 T5835 nummod −,cells
R4683 T5830 T5829 punct :,−
R4684 T5831 T5829 appos Flag-PKD3,−
R4685 T5832 T5833 advmod +,ve
R4686 T5833 T5829 appos ve,−
R4687 T5834 T5829 punct ),−
R4688 T5835 T5825 pobj cells,in
R4689 T5836 T5817 prep compared,reduced
R4690 T5837 T5836 prep to,compared
R4691 T5838 T5841 amod wild-type,cells
R4692 T5839 T5840 compound DT40,B
R4693 T5840 T5841 compound B,cells
R4694 T5841 T5837 pobj cells,to
R4695 T5842 T5841 punct (,cells
R4696 T5843 T5844 compound Fig.,3A
R4697 T5844 T5841 appos 3A,cells
R4698 T5845 T5844 cc and,3A
R4699 T5846 T5848 nsubj data,shown
R4700 T5847 T5848 neg not,shown
R4701 T5848 T5841 relcl shown,cells
R4702 T5849 T5817 punct ),reduced
R4703 T5850 T5809 punct .,revealed
R4704 T5851 T5860 advmod Nevertheless,was
R4705 T5852 T5860 punct ",",was
R4706 T5853 T5860 nsubj BCR-crosslinking,was
R4707 T5854 T5853 prep of,BCR-crosslinking
R4708 T5855 T5859 nummod PKD1/3,cells
R4709 T5856 T5859 nummod −,cells
R4710 T5857 T5859 nmod /,cells
R4711 T5858 T5859 amod −,cells
R4712 T5859 T5854 pobj cells,of
R4713 T5860 T5860 ROOT was,was
R4714 T5861 T5860 acomp sufficient,was
R4715 T5862 T5863 aux to,induce
R4716 T5863 T5861 xcomp induce,sufficient
R4717 T5864 T5865 det the,activation
R4718 T5865 T5863 dobj activation,induce
R4719 T5866 T5865 prep of,activation
R4720 T5867 T5868 det a,number
R4721 T5868 T5866 pobj number,of
R4722 T5869 T5868 prep of,number
R4723 T5870 T5869 pcomp signalling,of
R4724 T5871 T5870 dobj cascades,signalling
R4725 T5872 T5871 punct ",",cascades
R4726 T5873 T5871 amod similar,cascades
R4727 T5874 T5873 prep to,similar
R4728 T5875 T5876 nsubj that,observed
R4729 T5876 T5871 relcl observed,cascades
R4730 T5877 T5876 prep in,observed
R4731 T5878 T5879 amod wild-type,cells
R4732 T5879 T5877 pobj cells,in
R4733 T5880 T5871 punct (,cascades
R4734 T5881 T5882 compound Fig.,3B
R4735 T5882 T5871 appos 3B,cascades
R4736 T5883 T5871 punct ),cascades
R4737 T5884 T5860 punct .,was
R4738 T5885 T5888 advmod Hence,activation
R4739 T5886 T5888 punct ",",activation
R4740 T5887 T5888 amod BCR-induced,activation
R4741 T5888 T5909 nsubj activation,was
R4742 T5889 T5888 prep of,activation
R4743 T5890 T5891 det the,Akt
R4744 T5891 T5889 pobj Akt,of
R4745 T5892 T5891 punct ",",Akt
R4746 T5893 T5895 compound mTOR/p70,kinase
R4747 T5894 T5895 compound S6,kinase
R4748 T5895 T5891 appos kinase,Akt
R4749 T5896 T5898 punct (,shown
R4750 T5897 T5898 mark as,shown
R4751 T5898 T5888 advcl shown,activation
R4752 T5899 T5898 agent by,shown
R4753 T5900 T5908 nummod S6,pathways
R4754 T5901 T5902 amod ribosomal,protein
R4755 T5902 T5908 nmod protein,pathways
R4756 T5903 T5902 appos phosphorylation,protein
R4757 T5904 T5902 punct ),protein
R4758 T5905 T5902 cc and,protein
R4759 T5906 T5902 conj MAPK,protein
R4760 T5907 T5908 amod signalling,pathways
R4761 T5908 T5899 pobj pathways,by
R4762 T5909 T5909 ROOT was,was
R4763 T5910 T5909 advmod clearly,was
R4764 T5911 T5909 acomp detectable,was
R4765 T5912 T5911 prep in,detectable
R4766 T5913 T5914 compound PKD1/3-null,B
R4767 T5914 T5915 compound B,cells
R4768 T5915 T5912 pobj cells,in
R4769 T5916 T5918 punct (,3B
R4770 T5917 T5918 compound Fig.,3B
R4771 T5918 T5911 appos 3B,detectable
R4772 T5919 T5918 punct ),3B
R4773 T5920 T5909 punct .,was
R4774 T5921 T5941 advmod Furthermore,observed
R4775 T5922 T5941 punct ",",observed
R4776 T5923 T5925 amod enhanced,phosphorylation
R4777 T5924 T5925 compound tyrosine,phosphorylation
R4778 T5925 T5941 nsubjpass phosphorylation,observed
R4779 T5926 T5925 prep of,phosphorylation
R4780 T5927 T5929 amod multiple,proteins
R4781 T5928 T5929 amod cellular,proteins
R4782 T5929 T5926 pobj proteins,of
R4783 T5930 T5932 advmod as,as
R4784 T5931 T5932 advmod well,as
R4785 T5932 T5925 cc as,phosphorylation
R4786 T5933 T5934 det an,increase
R4787 T5934 T5925 conj increase,phosphorylation
R4788 T5935 T5934 prep in,increase
R4789 T5936 T5938 amod intracellular,levels
R4790 T5937 T5938 compound calcium,levels
R4791 T5938 T5935 pobj levels,in
R4792 T5939 T5941 auxpass was,observed
R4793 T5940 T5941 advmod also,observed
R4794 T5941 T5941 ROOT observed,observed
R4795 T5942 T5941 prep following,observed
R4796 T5943 T5944 compound BCR,stimulation
R4797 T5944 T5942 pobj stimulation,following
R4798 T5945 T5944 prep of,stimulation
R4799 T5946 T5948 nmod PKD1/3-null,cells
R4800 T5947 T5948 compound B,cells
R4801 T5948 T5945 pobj cells,of
R4802 T5949 T5950 punct (,data
R4803 T5950 T5948 appos data,cells
R4804 T5951 T5952 neg not,shown
R4805 T5952 T5950 acl shown,data
R4806 T5953 T5950 punct ),data
R4807 T5954 T5941 punct .,observed
R4808 T5955 T5957 nsubj We,observe
R4809 T5956 T5957 aux did,observe
R4810 T5957 T5957 ROOT observe,observe
R4811 T5958 T5970 mark that,induced
R4812 T5959 T5960 det the,strength
R4813 T5960 T5970 nsubj strength,induced
R4814 T5961 T5960 prep of,strength
R4815 T5962 T5961 pobj BCR,of
R4816 T5963 T5960 punct (,strength
R4817 T5964 T5960 cc but,strength
R4818 T5965 T5966 neg not,phorbol
R4819 T5966 T5967 advmod phorbol,ester
R4820 T5967 T5960 conj ester,strength
R4821 T5968 T5960 punct ),strength
R4822 T5969 T5970 punct -,induced
R4823 T5970 T5957 ccomp induced,observe
R4824 T5971 T5970 dobj regulation,induced
R4825 T5972 T5971 prep of,regulation
R4826 T5973 T5976 det the,pathway
R4827 T5974 T5976 amod Erk1-RSK1,pathway
R4828 T5975 T5976 compound signalling,pathway
R4829 T5976 T5972 pobj pathway,of
R4830 T5977 T5978 auxpass was,reduced
R4831 T5978 T5970 conj reduced,induced
R4832 T5979 T5978 prep in,reduced
R4833 T5980 T5985 nummod PKD1/3,cells
R4834 T5981 T5985 nummod −,cells
R4835 T5982 T5985 compound /,cells
R4836 T5983 T5985 compound −,cells
R4837 T5984 T5985 compound B,cells
R4838 T5985 T5979 pobj cells,in
R4839 T5986 T5978 prep compared,reduced
R4840 T5987 T5986 prep to,compared
R4841 T5988 T5990 amod wild-type,cells
R4842 T5989 T5990 compound B,cells
R4843 T5990 T5987 pobj cells,to
R4844 T5991 T5993 punct (,3B
R4845 T5992 T5993 compound Fig.,3B
R4846 T5993 T5990 appos 3B,cells
R4847 T5994 T5990 punct ),cells
R4848 T5995 T5957 punct .,observe
R4849 T5996 T5997 nummod One,interpretation
R4850 T5997 T6001 nsubj interpretation,is
R4851 T5998 T5997 prep of,interpretation
R4852 T5999 T6000 det this,data
R4853 T6000 T5998 pobj data,of
R4854 T6001 T6001 ROOT is,is
R4855 T6002 T6006 mark that,modulate
R4856 T6003 T6004 compound PKD,enzymes
R4857 T6004 T6006 nsubj enzymes,modulate
R4858 T6005 T6006 aux may,modulate
R4859 T6006 T6001 ccomp modulate,is
R4860 T6007 T6008 compound Erk,activation
R4861 T6008 T6006 dobj activation,modulate
R4862 T6009 T6001 punct .,is
R4863 T6010 T6017 advmod Indeed,linked
R4864 T6011 T6017 punct ",",linked
R4865 T6012 T6013 compound PKD,enzymes
R4866 T6013 T6017 nsubj enzymes,linked
R4867 T6014 T6017 aux have,linked
R4868 T6015 T6017 advmod previously,linked
R4869 T6016 T6017 auxpass been,linked
R4870 T6017 T6017 ROOT linked,linked
R4871 T6018 T6017 prep to,linked
R4872 T6019 T6020 det the,growth
R4873 T6020 T6018 pobj growth,to
R4874 T6021 T6023 amod factor-regulated,signalling
R4875 T6022 T6023 compound Erk,signalling
R4876 T6023 T6017 dobj signalling,linked
R4877 T6024 T6023 prep in,signalling
R4878 T6025 T6029 nmod fibroblast,lines
R4879 T6026 T6025 cc and,fibroblast
R4880 T6027 T6029 amod endothelial,lines
R4881 T6028 T6029 compound cell,lines
R4882 T6029 T6024 pobj lines,in
R4883 T6030 T6023 dobj [,signalling
R4884 T6031 T6030 nummod 33,[
R4885 T6032 T6033 nummod 35,]
R4886 T6033 T6030 appos ],[
R4887 T6034 T6017 punct .,linked
R4888 T6035 T6042 advmod However,reduced
R4889 T6036 T6042 punct ",",reduced
R4890 T6037 T6039 amod BCR-induced,phosphorylation
R4891 T6038 T6039 compound Erk,phosphorylation
R4892 T6039 T6042 nsubjpass phosphorylation,reduced
R4893 T6040 T6042 auxpass was,reduced
R4894 T6041 T6042 advmod also,reduced
R4895 T6042 T6042 ROOT reduced,reduced
R4896 T6043 T6042 prep in,reduced
R4897 T6044 T6052 nummod PKD1/3,cells
R4898 T6045 T6046 nummod −,/
R4899 T6046 T6052 compound /,cells
R4900 T6047 T6049 punct −,Flag-PKD3
R4901 T6048 T6049 punct -,Flag-PKD3
R4902 T6049 T6052 compound Flag-PKD3,cells
R4903 T6050 T6052 compound +,cells
R4904 T6051 T6052 compound B,cells
R4905 T6052 T6043 pobj cells,in
R4906 T6053 T6052 punct (,cells
R4907 T6054 T6054 ROOT data,data
R4908 T6055 T6056 neg not,shown
R4909 T6056 T6054 acl shown,data
R4910 T6057 T6054 punct ),data
R4911 T6058 T6042 advcl suggesting,reduced
R4912 T6059 T6074 mark that,−
R4913 T6060 T6062 amod reduced,levels
R4914 T6061 T6062 compound BCR,levels
R4915 T6062 T6074 nsubj levels,−
R4916 T6063 T6062 prep on,levels
R4917 T6064 T6065 det the,surface
R4918 T6065 T6063 pobj surface,on
R4919 T6066 T6065 prep of,surface
R4920 T6067 T6070 nummod PKD1/3,−
R4921 T6068 T6070 nummod −,−
R4922 T6069 T6070 compound /,−
R4923 T6070 T6066 pobj −,of
R4924 T6071 T6070 punct (,−
R4925 T6072 T6070 cc and,−
R4926 T6073 T6074 nsubj PKD1/3,−
R4927 T6074 T6058 ccomp −,suggesting
R4928 T6075 T6079 nummod /,+
R4929 T6076 T6078 punct −,Flag-PKD3
R4930 T6077 T6078 punct -,Flag-PKD3
R4931 T6078 T6079 compound Flag-PKD3,+
R4932 T6079 T6074 appos +,−
R4933 T6080 T6074 punct ),−
R4934 T6081 T6082 amod B,cells
R4935 T6082 T6085 nsubj cells,impact
R4936 T6083 T6085 aux may,impact
R4937 T6084 T6085 nsubj itself,impact
R4938 T6085 T6085 ROOT impact,impact
R4939 T6086 T6085 prep on,impact
R4940 T6087 T6088 det the,strength
R4941 T6088 T6086 pobj strength,on
R4942 T6089 T6088 prep of,strength
R4943 T6090 T6089 pobj activation,of
R4944 T6091 T6090 prep of,activation
R4945 T6092 T6096 det this,pathway
R4946 T6093 T6096 amod specific,pathway
R4947 T6094 T6096 amod intracellular,pathway
R4948 T6095 T6096 compound signalling,pathway
R4949 T6096 T6091 pobj pathway,of
R4950 T6097 T6085 punct .,impact
R4951 T6098 T6099 aux To,search
R4952 T6099 T6120 advcl search,used
R4953 T6100 T6099 prep for,search
R4954 T6101 T6104 amod other,targets
R4955 T6102 T6104 amod potential,targets
R4956 T6103 T6104 compound PKD,targets
R4957 T6104 T6100 pobj targets,for
R4958 T6105 T6107 nsubj that,show
R4959 T6106 T6107 aux may,show
R4960 T6107 T6104 relcl show,targets
R4961 T6108 T6109 amod defective,regulation
R4962 T6109 T6107 dobj regulation,show
R4963 T6110 T6109 prep in,regulation
R4964 T6111 T6116 compound PKD1/3,B
R4965 T6112 T6116 compound −,B
R4966 T6113 T6116 compound /,B
R4967 T6114 T6116 compound −,B
R4968 T6115 T6116 compound DT40,B
R4969 T6116 T6117 compound B,cells
R4970 T6117 T6110 pobj cells,in
R4971 T6118 T6120 punct ",",used
R4972 T6119 T6120 nsubj we,used
R4973 T6120 T6120 ROOT used,used
R4974 T6121 T6123 det a,substrate
R4975 T6122 T6123 compound PKD,substrate
R4976 T6123 T6120 dobj substrate,used
R4977 T6124 T6123 amod phospho-antibody,substrate
R4978 T6125 T6126 nsubj that,recognises
R4979 T6126 T6124 relcl recognises,phospho-antibody
R4980 T6127 T6129 compound consensus,sequences
R4981 T6128 T6129 compound phosphorylation,sequences
R4982 T6129 T6126 dobj sequences,recognises
R4983 T6130 T6129 acl targeted,sequences
R4984 T6131 T6130 agent by,targeted
R4985 T6132 T6133 compound PKD,enzymes
R4986 T6133 T6131 pobj enzymes,by
R4987 T6134 T6137 punct (,[
R4988 T6135 T6137 nmod LxRxxpS/T,[
R4989 T6136 T6137 punct ),[
R4990 T6137 T6133 appos [,enzymes
R4991 T6138 T6139 nummod 36,]
R4992 T6139 T6137 appos ],[
R4993 T6140 T6120 punct .,used
R4994 T6141 T6142 mark As,shown
R4995 T6142 T6160 advcl shown,was
R4996 T6143 T6142 prep in,shown
R4997 T6144 T6145 compound Fig.,3C
R4998 T6145 T6143 pobj 3C,in
R4999 T6146 T6145 punct ",",3C
R5000 T6147 T6160 nsubj phorbol,was
R5001 T6148 T6160 nsubj ester,was
R5002 T6149 T6148 punct -,ester
R5003 T6150 T6148 cc and,ester
R5004 T6151 T6152 amod BCR-induced,phosphorylation
R5005 T6152 T6148 conj phosphorylation,ester
R5006 T6153 T6152 prep of,phosphorylation
R5007 T6154 T6155 amod cellular,substrates
R5008 T6155 T6153 pobj substrates,of
R5009 T6156 T6155 acl detected,substrates
R5010 T6157 T6156 agent by,detected
R5011 T6158 T6159 det this,phospho-antibody
R5012 T6159 T6157 pobj phospho-antibody,by
R5013 T6160 T6160 ROOT was,was
R5014 T6161 T6160 acomp similar,was
R5015 T6162 T6161 prep in,similar
R5016 T6163 T6169 amod wild-type,cells
R5017 T6164 T6163 cc and,wild-type
R5018 T6165 T6163 conj PKD1/3,wild-type
R5019 T6166 T6169 compound −,cells
R5020 T6167 T6169 compound /,cells
R5021 T6168 T6169 compound −,cells
R5022 T6169 T6162 pobj cells,in
R5023 T6170 T6160 cc and,was
R5024 T6171 T6160 conj is,was
R5025 T6172 T6173 advmod therefore,independent
R5026 T6173 T6171 acomp independent,is
R5027 T6174 T6173 prep of,independent
R5028 T6175 T6176 compound PKD,enzymes
R5029 T6176 T6174 pobj enzymes,of
R5030 T6177 T6171 punct .,is
R5031 T6178 T6201 advmod However,prevented
R5032 T6179 T6201 punct ",",prevented
R5033 T6180 T6201 nsubj pretreatment,prevented
R5034 T6181 T6180 prep of,pretreatment
R5035 T6182 T6183 preconj both,wild-type
R5036 T6183 T6181 pobj wild-type,of
R5037 T6184 T6183 cc and,wild-type
R5038 T6185 T6183 conj PKD1/3,wild-type
R5039 T6186 T6188 compound −,−
R5040 T6187 T6188 compound /,−
R5041 T6188 T6191 compound −,cells
R5042 T6189 T6190 compound DT40,B
R5043 T6190 T6191 compound B,cells
R5044 T6191 T6183 appos cells,wild-type
R5045 T6192 T6180 prep with,pretreatment
R5046 T6193 T6192 pobj GF109203X,with
R5047 T6194 T6193 punct ",",GF109203X
R5048 T6195 T6197 det a,derivative
R5049 T6196 T6197 compound bisindoylmaleimide,derivative
R5050 T6197 T6193 appos derivative,GF109203X
R5051 T6198 T6199 nsubj that,inhibits
R5052 T6199 T6197 relcl inhibits,derivative
R5053 T6200 T6199 dobj PKCs,inhibits
R5054 T6201 T6201 ROOT prevented,prevented
R5055 T6202 T6203 det the,induction
R5056 T6203 T6201 dobj induction,prevented
R5057 T6204 T6203 prep of,induction
R5058 T6205 T6204 pobj proteins,of
R5059 T6206 T6207 nsubj that,contain
R5060 T6207 T6205 relcl contain,proteins
R5061 T6208 T6209 compound phosphorylated,LxRxxS/T
R5062 T6209 T6210 compound LxRxxS/T,motifs
R5063 T6210 T6207 dobj motifs,contain
R5064 T6211 T6201 punct .,prevented
R5065 T6212 T6216 advmod Thus,enzymes
R5066 T6213 T6216 nsubj loss,enzymes
R5067 T6214 T6213 prep of,loss
R5068 T6215 T6214 pobj PKD1/3,of
R5069 T6216 T6220 nsubj enzymes,disrupt
R5070 T6217 T6220 aux does,disrupt
R5071 T6218 T6220 neg not,disrupt
R5072 T6219 T6220 advmod globally,disrupt
R5073 T6220 T6220 ROOT disrupt,disrupt
R5074 T6221 T6222 det the,phosphorylation
R5075 T6222 T6220 dobj phosphorylation,disrupt
R5076 T6223 T6222 prep of,phosphorylation
R5077 T6224 T6225 amod cellular,proteins
R5078 T6225 T6223 pobj proteins,of
R5079 T6226 T6227 nsubj that,contain
R5080 T6227 T6225 relcl contain,proteins
R5081 T6228 T6229 compound LxRxxpS/T,motifs
R5082 T6229 T6227 dobj motifs,contain
R5083 T6230 T6220 punct .,disrupt
R5084 T6231 T6232 det This,result
R5085 T6232 T6233 nsubj result,is
R5086 T6233 T6233 ROOT is,is
R5087 T6234 T6236 advmod perhaps,surprising
R5088 T6235 T6236 neg not,surprising
R5089 T6236 T6233 acomp surprising,is
R5090 T6237 T6241 mark as,act
R5091 T6238 T6239 compound LxRxxS/T,motifs
R5092 T6239 T6241 nsubj motifs,act
R5093 T6240 T6241 advmod also,act
R5094 T6241 T6236 advcl act,surprising
R5095 T6242 T6241 prep as,act
R5096 T6243 T6244 amod good,substrates
R5097 T6244 T6242 pobj substrates,as
R5098 T6245 T6244 prep for,substrates
R5099 T6246 T6248 amod other,kinases
R5100 T6247 T6248 amod serine/threonine,kinases
R5101 T6248 T6245 pobj kinases,for
R5102 T6249 T6250 amod such,as
R5103 T6250 T6248 prep as,kinases
R5104 T6251 T6250 pobj MAPKAPK2,as
R5105 T6252 T6233 punct .,is
R5106 T6253 T6257 advmod However,provide
R5107 T6254 T6255 det these,experiments
R5108 T6255 T6257 nsubj experiments,provide
R5109 T6256 T6257 aux do,provide
R5110 T6257 T6257 ROOT provide,provide
R5111 T6258 T6259 amod further,evidence
R5112 T6259 T6257 dobj evidence,provide
R5113 T6260 T6263 mark that,are
R5114 T6261 T6262 amod phosphospecific,antisera
R5115 T6262 T6263 nsubj antisera,are
R5116 T6263 T6259 acl are,evidence
R5117 T6264 T6263 neg not,are
R5118 T6265 T6266 advmod sufficiently,selective
R5119 T6266 T6263 acomp selective,are
R5120 T6267 T6269 aux to,designated
R5121 T6268 T6269 auxpass be,designated
R5122 T6269 T6266 xcomp designated,selective
R5123 T6270 T6269 oprd kinase,designated
R5124 T6271 T6273 amod specific,antisera
R5125 T6272 T6273 compound substrate,antisera
R5126 T6273 T6270 appos antisera,kinase
R5127 T6274 T6257 punct .,provide
R5128 T6275 T6277 amod BCR-induced,pathways
R5129 T6276 T6277 amod signalling,pathways
R5130 T6277 T6278 nsubj pathways,culminate
R5131 T6278 T6278 ROOT culminate,culminate
R5132 T6279 T6278 prep in,culminate
R5133 T6280 T6281 det the,activation
R5134 T6281 T6279 pobj activation,in
R5135 T6282 T6281 prep of,activation
R5136 T6283 T6284 compound gene,transcription
R5137 T6284 T6285 compound transcription,events
R5138 T6285 T6282 pobj events,of
R5139 T6286 T6287 nsubj that,control
R5140 T6287 T6285 relcl control,events
R5141 T6288 T6290 compound B,survival
R5142 T6289 T6290 compound cell,survival
R5143 T6290 T6287 dobj survival,control
R5144 T6291 T6290 punct ",",survival
R5145 T6292 T6290 conj proliferation,survival
R5146 T6293 T6292 cc and,proliferation
R5147 T6294 T6292 conj function,proliferation
R5148 T6295 T6278 punct .,culminate
R5149 T6296 T6303 prep In,proposed
R5150 T6297 T6298 det this,context
R5151 T6298 T6296 pobj context,In
R5152 T6299 T6303 punct ",",proposed
R5153 T6300 T6303 nsubjpass it,proposed
R5154 T6301 T6303 aux has,proposed
R5155 T6302 T6303 auxpass been,proposed
R5156 T6303 T6303 ROOT proposed,proposed
R5157 T6304 T6303 dobj that,proposed
R5158 T6305 T6307 compound PKD,members
R5159 T6306 T6307 compound family,members
R5160 T6307 T6304 nsubj members,that
R5161 T6308 T6307 dobj control,members
R5162 T6309 T6308 prep of,control
R5163 T6310 T6311 compound gene,transcription
R5164 T6311 T6309 pobj transcription,of
R5165 T6312 T6307 prep through,members
R5166 T6313 T6312 pobj activation,through
R5167 T6314 T6313 prep of,activation
R5168 T6315 T6318 det the,factor
R5169 T6316 T6318 compound NFκB,factor
R5170 T6317 T6318 compound transcription,factor
R5171 T6318 T6314 pobj factor,of
R5172 T6319 T6303 punct .,proposed
R5173 T6320 T6326 advmod Thus,occurs
R5174 T6321 T6326 punct ",",occurs
R5175 T6322 T6323 amod PKD-mediated,activation
R5176 T6323 T6326 nsubj activation,occurs
R5177 T6324 T6323 prep of,activation
R5178 T6325 T6324 pobj NFκB,of
R5179 T6326 T6326 ROOT occurs,occurs
R5180 T6327 T6326 advmod downstream,occurs
R5181 T6328 T6327 prep of,downstream
R5182 T6329 T6330 det a,variety
R5183 T6330 T6328 pobj variety,of
R5184 T6331 T6330 prep of,variety
R5185 T6332 T6333 amod different,signals
R5186 T6333 T6331 pobj signals,of
R5187 T6334 T6333 punct ",",signals
R5188 T6335 T6333 prep including,signals
R5189 T6336 T6337 amod mROS/oxidative,stress
R5190 T6337 T6335 pobj stress,including
R5191 T6338 T6337 punct ",",stress
R5192 T6339 T6340 amod lysophosphatidic,acid
R5193 T6340 T6337 conj acid,stress
R5194 T6341 T6340 cc and,acid
R5195 T6342 T6344 det the,oncogene
R5196 T6343 T6344 compound Bcr-Abl,oncogene
R5197 T6344 T6340 conj oncogene,acid
R5198 T6345 T6347 compound [,]
R5199 T6346 T6347 compound "17,21,23,30,37",]
R5200 T6347 T6344 appos ],oncogene
R5201 T6348 T6326 punct .,occurs
R5202 T6349 T6357 advmod Furthermore,enhances
R5203 T6350 T6351 punct ",",expression
R5204 T6351 T6357 nsubj expression,enhances
R5205 T6352 T6351 prep of,expression
R5206 T6353 T6356 det an,mutant
R5207 T6354 T6356 amod activated,mutant
R5208 T6355 T6356 compound PKD1,mutant
R5209 T6356 T6352 pobj mutant,of
R5210 T6357 T6357 ROOT enhances,enhances
R5211 T6358 T6360 amod HPK1-mediated,activation
R5212 T6359 T6360 compound NFκB,activation
R5213 T6360 T6357 dobj activation,enhances
R5214 T6361 T6363 nmod [,]
R5215 T6362 T6363 nummod 38,]
R5216 T6363 T6357 npadvmod ],enhances
R5217 T6364 T6357 punct .,enhances
R5218 T6365 T6371 prep In,known
R5219 T6366 T6367 compound B,cells
R5220 T6367 T6365 pobj cells,In
R5221 T6368 T6371 punct ",",known
R5222 T6369 T6371 nsubjpass NFκB,known
R5223 T6370 T6371 auxpass is,known
R5224 T6371 T6371 ROOT known,known
R5225 T6372 T6374 aux to,regulated
R5226 T6373 T6374 auxpass be,regulated
R5227 T6374 T6371 xcomp regulated,known
R5228 T6375 T6374 prep via,regulated
R5229 T6376 T6375 pobj DAG,via
R5230 T6377 T6376 cc and,DAG
R5231 T6378 T6379 compound PKCβ,[
R5232 T6379 T6376 conj [,DAG
R5233 T6380 T6381 compound "39,40",]
R5234 T6381 T6376 conj ],DAG
R5235 T6382 T6371 cc but,known
R5236 T6383 T6385 mark whether,are
R5237 T6384 T6385 nsubj PKDs,are
R5238 T6385 T6371 conj are,known
R5239 T6386 T6387 amod key,intermediaries
R5240 T6387 T6385 attr intermediaries,are
R5241 T6388 T6385 prep for,are
R5242 T6389 T6390 compound NFκB,regulation
R5243 T6406 T6409 nsubjpass activity,induced
R5244 T6390 T6388 pobj regulation,for
R5245 T6407 T6409 auxpass was,induced
R5246 T6408 T6409 advmod strongly,induced
R5247 T6391 T6394 aux has,explored
R5248 T6409 T6402 ccomp induced,show
R5249 T6410 T6409 prep in,induced
R5250 T6392 T6394 neg not,explored
R5251 T6411 T6412 preconj both,wild-type
R5252 T6393 T6394 auxpass been,explored
R5253 T6412 T6417 nmod wild-type,−
R5254 T6394 T6385 conj explored,are
R5255 T6413 T6412 cc and,wild-type
R5256 T6414 T6412 conj PKD1/3,wild-type
R5257 T6415 T6417 compound −,−
R5258 T6395 T6371 punct .,known
R5259 T6416 T6417 compound /,−
R5260 T6417 T6420 compound −,cells
R5261 T6418 T6419 compound DT40,B
R5262 T6396 T6397 det The,data
R5263 T6419 T6420 compound B,cells
R5264 T6420 T6410 pobj cells,in
R5265 T6421 T6409 prep in,induced
R5266 T6397 T6402 nsubj data,show
R5267 T6422 T6421 pobj response,in
R5268 T6423 T6422 prep to,response
R5269 T6398 T6397 punct (,data
R5270 T6424 T6426 preconj either,ester
R5271 T6425 T6426 compound phorbol,ester
R5272 T6399 T6400 compound Fig.,4A
R5273 T6426 T6423 pobj ester,to
R5274 T6427 T6426 cc or,ester
R5275 T6428 T6429 compound BCR,stimulation
R5276 T6429 T6426 conj stimulation,ester
R5277 T6430 T6402 punct .,show
R5278 T6431 T6442 prep In,abolished
R5279 T6432 T6431 pobj contrast,In
R5280 T6400 T6397 appos 4A,data
R5281 T6433 T6442 punct ",",abolished
R5282 T6434 T6440 nmod BCR,activity
R5283 T6401 T6397 punct ),data
R5284 T6435 T6434 cc and,BCR
R5285 T6436 T6440 amod phorbol,activity
R5286 T6437 T6440 amod ester-induced,activity
R5287 T6438 T6440 nmod NFκB,activity
R5288 T6439 T6440 amod transcriptional,activity
R5289 T6402 T6402 ROOT show,show
R5290 T6440 T6442 nsubjpass activity,abolished
R5291 T6441 T6442 auxpass was,abolished
R5292 T6403 T6409 mark that,induced
R5293 T6442 T6442 ROOT abolished,abolished
R5294 T6443 T6442 prep in,abolished
R5295 T6444 T6449 compound PKCβ,B
R5296 T6404 T6406 nmod NFκB,activity
R5297 T6445 T6449 compound −,B
R5298 T6446 T6449 compound /,B
R5299 T6447 T6449 compound −,B
R5300 T6405 T6406 amod transcriptional,activity
R5301 T6448 T6449 compound DT40,B
R5302 T6449 T6450 compound B,cells
R5303 T6503 T6500 pobj cells,in
R5304 T6450 T6443 pobj cells,in
R5305 T6451 T6442 punct (,abolished
R5306 T6504 T6496 cc and,mediate
R5307 T6505 T6508 advmod hence,participate
R5308 T6452 T6453 compound Fig.,4A
R5309 T6506 T6508 aux do,participate
R5310 T6453 T6442 npadvmod 4A,abolished
R5311 T6454 T6442 punct ),abolished
R5312 T6455 T6442 punct ",",abolished
R5313 T6456 T6473 mark although,observed
R5314 T6507 T6508 neg not,participate
R5315 T6457 T6458 amod strong,activation
R5316 T6458 T6473 nsubjpass activation,observed
R5317 T6508 T6496 conj participate,mediate
R5318 T6459 T6458 prep of,activation
R5319 T6460 T6461 compound PKD,kinases
R5320 T6461 T6459 pobj kinases,of
R5321 T6509 T6508 prep in,participate
R5322 T6462 T6464 punct (,assessed
R5323 T6463 T6464 mark as,assessed
R5324 T6510 T6509 pobj DAG/PKC,in
R5325 T6464 T6473 advcl assessed,observed
R5326 T6465 T6464 agent by,assessed
R5327 T6466 T6465 pobj autophosphorylation,by
R5328 T6467 T6466 prep of,autophosphorylation
R5329 T6468 T6467 pobj PKD1,of
R5330 T6469 T6466 prep at,autophosphorylation
R5331 T6470 T6469 pobj S916,at
R5332 T6471 T6464 punct ),assessed
R5333 T6472 T6473 auxpass was,observed
R5334 T6511 T6490 conj mediated,are
R5335 T6473 T6442 advcl observed,abolished
R5336 T6474 T6473 prep in,observed
R5337 T6512 T6511 dobj control,mediated
R5338 T6475 T6477 det the,−
R5339 T6476 T6477 compound PKCβ,−
R5340 T6477 T6474 pobj −,in
R5341 T6478 T6442 conj /,abolished
R5342 T6513 T6512 prep of,control
R5343 T6479 T6480 nummod −,cells
R5344 T6480 T6478 dobj cells,/
R5345 T6481 T6483 punct (,4B
R5346 T6514 T6513 pobj NFκB,of
R5347 T6482 T6483 compound Fig.,4B
R5348 T6483 T6478 parataxis 4B,/
R5349 T6484 T6483 punct ),4B
R5350 T6515 T6490 punct .,are
R5351 T6485 T6442 punct .,abolished
R5353 T6486 T6490 advmod Thus,are
R5354 T6487 T6490 punct ",",are
R5355 T6488 T6489 compound PKD,kinases
R5356 T6489 T6490 nsubj kinases,are
R5357 T6490 T6490 ROOT are,are
R5358 T6491 T6492 advmod neither,essential
R5359 T6492 T6490 acomp essential,are
R5360 T6493 T6492 cc nor,essential
R5361 T6494 T6492 conj sufficient,essential
R5362 T6495 T6496 aux to,mediate
R5363 T6496 T6494 xcomp mediate,sufficient
R5364 T6497 T6499 amod BCR-induced,activation
R5365 T6498 T6499 compound NFκB,activation
R5366 T6499 T6496 dobj activation,mediate
R5367 T6500 T6499 prep in,activation
R5368 T6501 T6502 compound DT40,B
R5369 T6502 T6503 compound B,cells