Id |
Subject |
Object |
Predicate |
Lexical cue |
T10324 |
11-17 |
JJ |
denotes |
Recent |
T10325 |
18-25 |
NNS |
denotes |
studies |
T10326 |
26-30 |
VBP |
denotes |
have |
T10327 |
31-43 |
VBN |
denotes |
demonstrated |
T10328 |
44-46 |
DT |
denotes |
an |
T10329 |
47-56 |
JJ |
denotes |
important |
T10330 |
57-61 |
NN |
denotes |
role |
T10331 |
62-65 |
IN |
denotes |
for |
T10332 |
66-69 |
NN |
denotes |
BMP |
T10333 |
70-81 |
RB |
denotes |
superfamily |
T10334 |
82-89 |
NNS |
denotes |
members |
T10335 |
90-92 |
IN |
denotes |
in |
T10336 |
93-106 |
JJ |
denotes |
hematopoietic |
T10337 |
107-111 |
NN |
denotes |
stem |
T10338 |
112-117 |
NNS |
denotes |
cells |
T10339 |
117-118 |
, |
denotes |
, |
T10340 |
119-124 |
JJ |
denotes |
early |
T10341 |
125-135 |
NNS |
denotes |
thymocytes |
T10342 |
136-137 |
NNP |
denotes |
[ |
T10343 |
137-140 |
CD |
denotes |
6,7 |
T10344 |
140-141 |
NNP |
denotes |
] |
T10345 |
142-145 |
CC |
denotes |
and |
T10346 |
146-152 |
NNP |
denotes |
B-cell |
T10347 |
153-165 |
NNS |
denotes |
malignancies |
T10348 |
166-167 |
NNP |
denotes |
[ |
T10349 |
167-174 |
CD |
denotes |
8,11,12 |
T10350 |
174-175 |
NNP |
denotes |
] |
T10351 |
175-176 |
, |
denotes |
, |
T10352 |
177-180 |
CC |
denotes |
but |
T10353 |
181-182 |
DT |
denotes |
a |
T10354 |
183-187 |
NN |
denotes |
role |
T10355 |
188-191 |
IN |
denotes |
for |
T10356 |
192-196 |
NNS |
denotes |
BMPs |
T10357 |
197-199 |
IN |
denotes |
in |
T10358 |
200-206 |
JJ |
denotes |
normal |
T10359 |
207-212 |
JJ |
denotes |
human |
T10360 |
213-214 |
NNP |
denotes |
B |
T10361 |
215-220 |
NNS |
denotes |
cells |
T10362 |
221-224 |
VBZ |
denotes |
has |
T10363 |
225-235 |
RB |
denotes |
previously |
T10364 |
236-239 |
RB |
denotes |
not |
T10365 |
240-244 |
VBN |
denotes |
been |
T10366 |
245-253 |
VBN |
denotes |
reported |
T10367 |
253-254 |
. |
denotes |
. |
T10368 |
255-258 |
DT |
denotes |
The |
T10369 |
259-266 |
JJ |
denotes |
present |
T10370 |
267-272 |
NN |
denotes |
study |
T10371 |
273-285 |
VBD |
denotes |
demonstrated |
T10372 |
286-287 |
DT |
denotes |
a |
T10373 |
288-299 |
JJ |
denotes |
significant |
T10374 |
300-317 |
JJ |
denotes |
antiproliferative |
T10375 |
318-324 |
NN |
denotes |
effect |
T10376 |
325-327 |
IN |
denotes |
of |
T10377 |
328-333 |
NN |
denotes |
BMP-6 |
T10378 |
334-336 |
IN |
denotes |
in |
T10379 |
337-347 |
JJ |
denotes |
peripheral |
T10380 |
348-353 |
NN |
denotes |
blood |
T10381 |
354-358 |
NNP |
denotes |
CD19 |
T10382 |
358-359 |
NNP |
denotes |
+ |
T10383 |
360-361 |
NNP |
denotes |
B |
T10384 |
362-367 |
NNS |
denotes |
cells |
T10385 |
367-368 |
. |
denotes |
. |
T10386 |
369-381 |
RB |
denotes |
Additionally |
T10387 |
381-382 |
, |
denotes |
, |
T10388 |
383-388 |
NNP |
denotes |
BMP-6 |
T10389 |
389-396 |
VBD |
denotes |
induced |
T10390 |
397-401 |
NN |
denotes |
cell |
T10391 |
402-407 |
NN |
denotes |
death |
T10392 |
408-410 |
IN |
denotes |
in |
T10393 |
411-415 |
NNP |
denotes |
CD27 |
T10394 |
415-416 |
NNP |
denotes |
+ |
T10395 |
417-423 |
NN |
denotes |
memory |
T10396 |
424-425 |
NNP |
denotes |
B |
T10397 |
426-431 |
NNS |
denotes |
cells |
T10398 |
432-434 |
RB |
denotes |
as |
T10399 |
435-439 |
RB |
denotes |
well |
T10400 |
440-442 |
IN |
denotes |
as |
T10401 |
443-445 |
IN |
denotes |
in |
T10402 |
446-447 |
DT |
denotes |
a |
T10403 |
448-455 |
NNP |
denotes |
Burkitt |
T10404 |
456-464 |
NN |
denotes |
lymphoma |
T10405 |
465-469 |
NN |
denotes |
cell |
T10406 |
470-474 |
NN |
denotes |
line |
T10407 |
475-476 |
-LRB- |
denotes |
( |
T10408 |
476-481 |
NNP |
denotes |
Ramos |
T10409 |
481-482 |
-RRB- |
denotes |
) |
T10410 |
482-483 |
. |
denotes |
. |
T10411 |
484-495 |
RB |
denotes |
Importantly |
T10412 |
495-496 |
, |
denotes |
, |
T10413 |
497-502 |
NNP |
denotes |
BMP-6 |
T10414 |
503-510 |
VBD |
denotes |
induced |
T10415 |
511-512 |
DT |
denotes |
a |
T10416 |
513-518 |
JJ |
denotes |
rapid |
T10417 |
519-522 |
CC |
denotes |
and |
T10418 |
523-529 |
JJ |
denotes |
marked |
T10419 |
530-538 |
NN |
denotes |
increase |
T10420 |
539-541 |
IN |
denotes |
in |
T10421 |
542-548 |
NNP |
denotes |
Smad-1 |
T10422 |
548-549 |
CD |
denotes |
/ |
T10423 |
549-552 |
CD |
denotes |
5/8 |
T10424 |
553-568 |
NN |
denotes |
phosphorylation |
T10425 |
568-569 |
. |
denotes |
. |
T10426 |
570-581 |
RB |
denotes |
Furthermore |
T10427 |
581-582 |
, |
denotes |
, |
T10428 |
583-586 |
DT |
denotes |
the |
T10429 |
587-592 |
NNP |
denotes |
BMP-6 |
T10430 |
593-600 |
VBD |
denotes |
induced |
T10431 |
601-605 |
NNP |
denotes |
Smad |
T10432 |
606-621 |
NN |
denotes |
phosphorylation |
T10433 |
622-625 |
VBD |
denotes |
was |
T10434 |
626-634 |
VBN |
denotes |
followed |
T10435 |
635-637 |
IN |
denotes |
by |
T10436 |
638-639 |
DT |
denotes |
a |
T10437 |
640-649 |
JJ |
denotes |
selective |
T10438 |
650-662 |
NN |
denotes |
upregulation |
T10439 |
663-665 |
IN |
denotes |
of |
T10440 |
666-669 |
NNP |
denotes |
Id1 |
T10441 |
670-674 |
NNP |
denotes |
mRNA |
T10442 |
675-678 |
CC |
denotes |
and |
T10443 |
679-689 |
JJ |
denotes |
subsequent |
T10444 |
690-693 |
JJ |
denotes |
Id1 |
T10445 |
694-701 |
NN |
denotes |
protein |
T10446 |
701-702 |
. |
denotes |
. |
T10447 |
703-705 |
IN |
denotes |
In |
T10448 |
706-709 |
DT |
denotes |
the |
T10449 |
710-717 |
JJ |
denotes |
present |
T10450 |
718-723 |
NN |
denotes |
study |
T10451 |
723-724 |
, |
denotes |
, |
T10452 |
725-728 |
DT |
denotes |
the |
T10453 |
729-741 |
VBN |
denotes |
demonstrated |
T10454 |
742-759 |
JJ |
denotes |
antiproliferative |
T10455 |
760-766 |
NN |
denotes |
effect |
T10456 |
767-769 |
IN |
denotes |
of |
T10457 |
770-775 |
NN |
denotes |
BMP-6 |
T10458 |
776-778 |
IN |
denotes |
in |
T10459 |
779-787 |
JJ |
denotes |
anti-IgM |
T10460 |
788-795 |
VBN |
denotes |
treated |
T10461 |
796-797 |
NNP |
denotes |
B |
T10462 |
798-803 |
NNS |
denotes |
cells |
T10463 |
804-807 |
VBD |
denotes |
was |
T10464 |
808-819 |
JJ |
denotes |
significant |
T10465 |
820-823 |
CC |
denotes |
and |
T10466 |
824-838 |
JJ |
denotes |
dose-dependent |
T10467 |
838-839 |
. |
denotes |
. |
T10468 |
840-851 |
RB |
denotes |
Importantly |
T10469 |
851-852 |
, |
denotes |
, |
T10470 |
853-856 |
DT |
denotes |
the |
T10471 |
857-875 |
JJ |
denotes |
anti-proliferative |
T10472 |
876-882 |
NN |
denotes |
effect |
T10473 |
883-885 |
IN |
denotes |
of |
T10474 |
886-891 |
NN |
denotes |
BMP-6 |
T10475 |
892-897 |
MD |
denotes |
could |
T10476 |
898-900 |
VB |
denotes |
be |
T10477 |
901-911 |
RB |
denotes |
completely |
T10478 |
912-923 |
VBN |
denotes |
neutralized |
T10479 |
924-926 |
IN |
denotes |
by |
T10480 |
927-930 |
DT |
denotes |
the |
T10481 |
931-934 |
NN |
denotes |
use |
T10482 |
935-937 |
IN |
denotes |
of |
T10483 |
938-939 |
DT |
denotes |
a |
T10484 |
940-947 |
JJ |
denotes |
natural |
T10485 |
948-957 |
NN |
denotes |
inhibitor |
T10486 |
957-958 |
, |
denotes |
, |
T10487 |
959-965 |
NNP |
denotes |
Noggin |
T10488 |
965-966 |
. |
denotes |
. |
T10489 |
967-971 |
DT |
denotes |
This |
T10490 |
972-974 |
VBZ |
denotes |
is |
T10491 |
975-977 |
IN |
denotes |
in |
T10492 |
978-982 |
NN |
denotes |
line |
T10493 |
983-987 |
IN |
denotes |
with |
T10494 |
988-994 |
NNS |
denotes |
others |
T10495 |
994-995 |
, |
denotes |
, |
T10496 |
996-1003 |
VBG |
denotes |
showing |
T10497 |
1004-1008 |
IN |
denotes |
that |
T10498 |
1009-1015 |
NNP |
denotes |
Noggin |
T10499 |
1016-1019 |
MD |
denotes |
can |
T10500 |
1020-1028 |
VB |
denotes |
function |
T10501 |
1029-1031 |
IN |
denotes |
as |
T10502 |
1032-1033 |
DT |
denotes |
a |
T10503 |
1034-1039 |
NN |
denotes |
BMP-6 |
T10504 |
1040-1050 |
NN |
denotes |
antagonist |
T10505 |
1051-1052 |
NNP |
denotes |
[ |
T10506 |
1052-1057 |
CD |
denotes |
21,22 |
T10507 |
1057-1058 |
NNP |
denotes |
] |
T10508 |
1058-1059 |
. |
denotes |
. |
T10509 |
1060-1062 |
IN |
denotes |
In |
T10510 |
1063-1071 |
NN |
denotes |
addition |
T10511 |
1071-1072 |
, |
denotes |
, |
T10512 |
1073-1076 |
DT |
denotes |
the |
T10513 |
1077-1088 |
NN |
denotes |
combination |
T10514 |
1089-1091 |
IN |
denotes |
of |
T10515 |
1092-1099 |
JJ |
denotes |
soluble |
T10516 |
1100-1110 |
JJ |
denotes |
BMP-RIB-Fc |
T10517 |
1111-1114 |
CC |
denotes |
and |
T10518 |
1115-1125 |
JJ |
denotes |
BMP-RII-Fc |
T10519 |
1126-1132 |
NN |
denotes |
fusion |
T10520 |
1133-1141 |
NNS |
denotes |
proteins |
T10521 |
1142-1146 |
RB |
denotes |
also |
T10522 |
1147-1158 |
VBD |
denotes |
neutralized |
T10523 |
1159-1162 |
DT |
denotes |
the |
T10524 |
1163-1181 |
JJ |
denotes |
anti-proliferative |
T10525 |
1182-1188 |
NN |
denotes |
effect |
T10526 |
1189-1191 |
IN |
denotes |
of |
T10527 |
1192-1197 |
NN |
denotes |
BMP-6 |
T10528 |
1198-1200 |
IN |
denotes |
in |
T10529 |
1201-1206 |
JJ |
denotes |
human |
T10530 |
1207-1208 |
NNP |
denotes |
B |
T10531 |
1209-1214 |
NNS |
denotes |
cells |
T10532 |
1214-1215 |
. |
denotes |
. |
T10533 |
1216-1229 |
RB |
denotes |
Interestingly |
T10534 |
1229-1230 |
, |
denotes |
, |
T10535 |
1231-1233 |
IN |
denotes |
as |
T10536 |
1234-1237 |
IN |
denotes |
for |
T10537 |
1238-1243 |
JJ |
denotes |
other |
T10538 |
1244-1247 |
NNP |
denotes |
TGF |
T10539 |
1248-1254 |
NN |
denotes |
family |
T10540 |
1255-1262 |
NNS |
denotes |
members |
T10541 |
1262-1263 |
, |
denotes |
, |
T10542 |
1264-1276 |
JJ |
denotes |
bifunctional |
T10543 |
1277-1284 |
NNS |
denotes |
effects |
T10544 |
1285-1289 |
VBP |
denotes |
have |
T10545 |
1290-1294 |
RB |
denotes |
also |
T10546 |
1295-1299 |
VBN |
denotes |
been |
T10547 |
1300-1312 |
VBN |
denotes |
demonstrated |
T10548 |
1313-1316 |
IN |
denotes |
for |
T10549 |
1317-1321 |
NNS |
denotes |
BMPs |
T10550 |
1321-1322 |
. |
denotes |
. |
T10551 |
1323-1330 |
IN |
denotes |
Whereas |
T10552 |
1331-1338 |
JJ |
denotes |
several |
T10553 |
1339-1341 |
IN |
denotes |
of |
T10554 |
1342-1345 |
DT |
denotes |
the |
T10555 |
1346-1350 |
NNS |
denotes |
BMPs |
T10556 |
1351-1355 |
VBP |
denotes |
have |
T10557 |
1356-1360 |
VBN |
denotes |
been |
T10558 |
1361-1366 |
VBN |
denotes |
shown |
T10559 |
1367-1369 |
TO |
denotes |
to |
T10560 |
1370-1377 |
VB |
denotes |
promote |
T10561 |
1378-1391 |
NN |
denotes |
proliferation |
T10562 |
1392-1394 |
IN |
denotes |
in |
T10563 |
1395-1402 |
JJ |
denotes |
various |
T10564 |
1403-1407 |
NN |
denotes |
cell |
T10565 |
1408-1413 |
NNS |
denotes |
types |
T10566 |
1414-1423 |
VBG |
denotes |
including |
T10567 |
1424-1435 |
NNS |
denotes |
condrocytes |
T10568 |
1436-1437 |
NNP |
denotes |
[ |
T10569 |
1437-1439 |
CD |
denotes |
23 |
T10570 |
1439-1440 |
NNP |
denotes |
] |
T10571 |
1440-1441 |
, |
denotes |
, |
T10572 |
1442-1447 |
NN |
denotes |
liver |
T10573 |
1448-1449 |
NNP |
denotes |
[ |
T10574 |
1449-1451 |
CD |
denotes |
24 |
T10575 |
1451-1452 |
NNP |
denotes |
] |
T10576 |
1453-1456 |
CC |
denotes |
and |
T10577 |
1457-1466 |
NN |
denotes |
granulosa |
T10578 |
1467-1472 |
NNS |
denotes |
cells |
T10579 |
1473-1474 |
NNP |
denotes |
[ |
T10580 |
1474-1476 |
CD |
denotes |
25 |
T10581 |
1476-1477 |
NNP |
denotes |
] |
T10582 |
1477-1478 |
, |
denotes |
, |
T10583 |
1479-1496 |
JJ |
denotes |
antiproliferative |
T10584 |
1497-1504 |
NNS |
denotes |
effects |
T10585 |
1505-1508 |
CC |
denotes |
and |
T10586 |
1509-1518 |
NN |
denotes |
induction |
T10587 |
1519-1521 |
IN |
denotes |
of |
T10588 |
1522-1531 |
NN |
denotes |
apoptosis |
T10589 |
1532-1535 |
VBZ |
denotes |
has |
T10590 |
1536-1540 |
VBN |
denotes |
been |
T10591 |
1541-1549 |
VBN |
denotes |
reported |
T10592 |
1550-1553 |
IN |
denotes |
for |
T10593 |
1554-1555 |
NNP |
denotes |
B |
T10594 |
1556-1559 |
CC |
denotes |
and |
T10595 |
1560-1561 |
NNP |
denotes |
T |
T10596 |
1562-1569 |
NN |
denotes |
lineage |
T10597 |
1570-1575 |
NNS |
denotes |
cells |
T10598 |
1575-1576 |
. |
denotes |
. |
T10599 |
1577-1584 |
JJ |
denotes |
Similar |
T10600 |
1585-1592 |
NNS |
denotes |
effects |
T10601 |
1593-1595 |
IN |
denotes |
as |
T10602 |
1596-1608 |
VBN |
denotes |
demonstrated |
T10603 |
1609-1612 |
IN |
denotes |
for |
T10604 |
1613-1618 |
NN |
denotes |
BMP-6 |
T10605 |
1619-1621 |
IN |
denotes |
on |
T10606 |
1622-1627 |
JJ |
denotes |
human |
T10607 |
1628-1629 |
NNP |
denotes |
B |
T10608 |
1630-1635 |
NNS |
denotes |
cells |
T10609 |
1636-1638 |
IN |
denotes |
in |
T10610 |
1639-1642 |
DT |
denotes |
the |
T10611 |
1643-1650 |
JJ |
denotes |
present |
T10612 |
1651-1656 |
NN |
denotes |
study |
T10613 |
1656-1657 |
, |
denotes |
, |
T10614 |
1658-1662 |
VBD |
denotes |
were |
T10615 |
1663-1675 |
VBN |
denotes |
demonstrated |
T10616 |
1676-1679 |
IN |
denotes |
for |
T10617 |
1680-1685 |
NNP |
denotes |
BMP-2 |
T10618 |
1685-1686 |
, |
denotes |
, |
T10619 |
1687-1688 |
CD |
denotes |
4 |
T10620 |
1688-1689 |
, |
denotes |
, |
T10621 |
1690-1691 |
CD |
denotes |
6 |
T10622 |
1692-1695 |
CC |
denotes |
and |
T10623 |
1696-1698 |
CD |
denotes |
-7 |
T10624 |
1699-1701 |
IN |
denotes |
in |
T10625 |
1702-1707 |
JJ |
denotes |
human |
T10626 |
1708-1715 |
NN |
denotes |
myeloma |
T10627 |
1716-1721 |
NNS |
denotes |
cells |
T10628 |
1722-1723 |
NNP |
denotes |
[ |
T10629 |
1723-1727 |
CD |
denotes |
9-11 |
T10630 |
1727-1728 |
NNP |
denotes |
] |
T10631 |
1728-1729 |
. |
denotes |
. |
T10632 |
1730-1735 |
JJ |
denotes |
Other |
T10633 |
1736-1743 |
NNS |
denotes |
members |
T10634 |
1744-1746 |
IN |
denotes |
of |
T10635 |
1747-1750 |
DT |
denotes |
the |
T10636 |
1751-1761 |
NNP |
denotes |
BMP-family |
T10637 |
1762-1766 |
VBP |
denotes |
have |
T10638 |
1767-1771 |
RB |
denotes |
also |
T10639 |
1772-1776 |
VBN |
denotes |
been |
T10640 |
1777-1785 |
VBN |
denotes |
reported |
T10641 |
1786-1788 |
TO |
denotes |
to |
T10642 |
1789-1795 |
VB |
denotes |
induce |
T10643 |
1796-1805 |
NN |
denotes |
apoptosis |
T10644 |
1805-1806 |
, |
denotes |
, |
T10645 |
1807-1816 |
VBG |
denotes |
including |
T10646 |
1817-1819 |
IN |
denotes |
in |
T10647 |
1820-1825 |
NN |
denotes |
mouse |
T10648 |
1826-1827 |
NNP |
denotes |
B |
T10649 |
1828-1835 |
NN |
denotes |
lineage |
T10650 |
1836-1841 |
NNS |
denotes |
cells |
T10651 |
1842-1843 |
NNP |
denotes |
[ |
T10652 |
1843-1845 |
CD |
denotes |
26 |
T10653 |
1845-1846 |
NNP |
denotes |
] |
T10654 |
1846-1847 |
. |
denotes |
. |
T10655 |
1848-1860 |
RB |
denotes |
Additionally |
T10656 |
1860-1861 |
, |
denotes |
, |
T10657 |
1862-1867 |
JJ |
denotes |
BMP-4 |
T10658 |
1868-1876 |
NNS |
denotes |
inhibits |
T10659 |
1877-1886 |
VBP |
denotes |
thymocyte |
T10660 |
1887-1900 |
NN |
denotes |
proliferation |
T10661 |
1901-1902 |
NN |
denotes |
[ |
T10662 |
1902-1903 |
CD |
denotes |
6 |
T10663 |
1903-1904 |
NNP |
denotes |
] |
T10664 |
1904-1905 |
. |
denotes |
. |
T10665 |
1906-1911 |
VBN |
denotes |
Taken |
T10666 |
1912-1920 |
RB |
denotes |
together |
T10667 |
1920-1921 |
, |
denotes |
, |
T10668 |
1922-1927 |
DT |
denotes |
these |
T10669 |
1928-1932 |
NNS |
denotes |
data |
T10670 |
1933-1940 |
VBP |
denotes |
suggest |
T10671 |
1941-1945 |
IN |
denotes |
that |
T10672 |
1946-1949 |
DT |
denotes |
the |
T10673 |
1950-1954 |
NN |
denotes |
role |
T10674 |
1955-1957 |
IN |
denotes |
of |
T10675 |
1958-1962 |
NNS |
denotes |
BMPs |
T10676 |
1963-1965 |
IN |
denotes |
in |
T10677 |
1966-1969 |
DT |
denotes |
the |
T10678 |
1970-1980 |
NN |
denotes |
regulation |
T10679 |
1981-1983 |
IN |
denotes |
of |
T10680 |
1984-1997 |
NN |
denotes |
proliferation |
T10681 |
1998-2001 |
CC |
denotes |
and |
T10682 |
2002-2011 |
NN |
denotes |
apoptosis |
T10683 |
2012-2014 |
VBZ |
denotes |
is |
T10684 |
2015-2021 |
RB |
denotes |
highly |
T10685 |
2022-2026 |
NN |
denotes |
cell |
T10686 |
2027-2031 |
NN |
denotes |
type |
T10687 |
2032-2041 |
JJ |
denotes |
dependent |
T10688 |
2041-2042 |
. |
denotes |
. |
T10689 |
2043-2045 |
TO |
denotes |
To |
T10690 |
2046-2053 |
VB |
denotes |
examine |
T10691 |
2054-2057 |
WRB |
denotes |
how |
T10692 |
2058-2063 |
JJ |
denotes |
BMP-6 |
T10693 |
2064-2070 |
VBZ |
denotes |
exerts |
T10694 |
2071-2074 |
PRP$ |
denotes |
its |
T10695 |
2075-2085 |
JJ |
denotes |
functional |
T10696 |
2086-2093 |
NNS |
denotes |
effects |
T10697 |
2094-2096 |
IN |
denotes |
in |
T10698 |
2097-2098 |
NNP |
denotes |
B |
T10699 |
2099-2104 |
NNS |
denotes |
cells |
T10700 |
2104-2105 |
, |
denotes |
, |
T10701 |
2106-2108 |
PRP |
denotes |
we |
T10702 |
2109-2117 |
VBD |
denotes |
analysed |
T10703 |
2118-2121 |
NN |
denotes |
BMP |
T10704 |
2122-2130 |
NN |
denotes |
receptor |
T10705 |
2131-2141 |
NN |
denotes |
expression |
T10706 |
2142-2144 |
IN |
denotes |
by |
T10707 |
2145-2152 |
JJ |
denotes |
western |
T10708 |
2153-2157 |
NN |
denotes |
blot |
T10709 |
2158-2166 |
NN |
denotes |
analysis |
T10710 |
2166-2167 |
. |
denotes |
. |
T10711 |
2168-2173 |
NNP |
denotes |
Human |
T10712 |
2174-2184 |
JJ |
denotes |
peripheral |
T10713 |
2185-2186 |
NNP |
denotes |
B |
T10714 |
2187-2192 |
NNS |
denotes |
cells |
T10715 |
2193-2197 |
VBD |
denotes |
were |
T10716 |
2198-2203 |
VBN |
denotes |
found |
T10717 |
2204-2206 |
TO |
denotes |
to |
T10718 |
2207-2214 |
VB |
denotes |
express |
T10719 |
2215-2218 |
DT |
denotes |
the |
T10720 |
2219-2222 |
NN |
denotes |
BMP |
T10721 |
2223-2227 |
NN |
denotes |
type |
T10722 |
2228-2229 |
PRP |
denotes |
I |
T10723 |
2230-2239 |
NNS |
denotes |
receptors |
T10724 |
2240-2247 |
NNP |
denotes |
Act-RIA |
T10725 |
2248-2251 |
CC |
denotes |
and |
T10726 |
2252-2259 |
NNP |
denotes |
BMP-RIB |
T10727 |
2259-2260 |
, |
denotes |
, |
T10728 |
2261-2264 |
CC |
denotes |
and |
T10729 |
2265-2268 |
DT |
denotes |
the |
T10730 |
2269-2273 |
NN |
denotes |
type |
T10731 |
2274-2286 |
NNS |
denotes |
II-receptors |
T10732 |
2287-2294 |
NNP |
denotes |
BMP-RII |
T10733 |
2295-2298 |
CC |
denotes |
and |
T10734 |
2299-2307 |
NNP |
denotes |
Act-RIIb |
T10735 |
2307-2308 |
, |
denotes |
, |
T10736 |
2309-2314 |
WDT |
denotes |
which |
T10737 |
2315-2321 |
VBP |
denotes |
signal |
T10738 |
2322-2327 |
IN |
denotes |
after |
T10739 |
2328-2335 |
JJ |
denotes |
binding |
T10740 |
2336-2338 |
IN |
denotes |
of |
T10741 |
2339-2346 |
JJ |
denotes |
several |
T10742 |
2347-2351 |
NNS |
denotes |
BMPs |
T10743 |
2351-2352 |
, |
denotes |
, |
T10744 |
2353-2362 |
VBG |
denotes |
including |
T10745 |
2363-2368 |
NNP |
denotes |
BMP-6 |
T10746 |
2369-2370 |
NNP |
denotes |
[ |
T10747 |
2370-2375 |
CD |
denotes |
16,13 |
T10748 |
2375-2376 |
NNP |
denotes |
] |
T10749 |
2376-2377 |
. |
denotes |
. |
T10750 |
2378-2380 |
TO |
denotes |
To |
T10751 |
2381-2388 |
RBR |
denotes |
further |
T10752 |
2389-2396 |
VB |
denotes |
explore |
T10753 |
2397-2402 |
NNP |
denotes |
BMP-6 |
T10754 |
2403-2410 |
JJ |
denotes |
induced |
T10755 |
2411-2421 |
NN |
denotes |
signalling |
T10756 |
2421-2422 |
, |
denotes |
, |
T10757 |
2423-2433 |
NN |
denotes |
activation |
T10758 |
2434-2436 |
IN |
denotes |
of |
T10759 |
2437-2444 |
JJ |
denotes |
several |
T10760 |
2445-2453 |
NNS |
denotes |
pathways |
T10761 |
2454-2456 |
VBZ |
denotes |
is |
T10762 |
2457-2465 |
JJ |
denotes |
possible |
T10763 |
2465-2466 |
. |
denotes |
. |
T10764 |
2467-2470 |
DT |
denotes |
The |
T10765 |
2471-2476 |
JJ |
denotes |
major |
T10766 |
2477-2487 |
JJ |
denotes |
signalling |
T10767 |
2488-2495 |
NN |
denotes |
pathway |
T10768 |
2496-2501 |
VBN |
denotes |
known |
T10769 |
2502-2504 |
TO |
denotes |
to |
T10770 |
2505-2509 |
NN |
denotes |
date |
T10771 |
2509-2510 |
, |
denotes |
, |
T10772 |
2511-2513 |
VBZ |
denotes |
is |
T10773 |
2514-2524 |
NN |
denotes |
activation |
T10774 |
2525-2527 |
IN |
denotes |
of |
T10775 |
2528-2535 |
NNS |
denotes |
R-Smads |
T10776 |
2536-2537 |
NNP |
denotes |
[ |
T10777 |
2537-2542 |
CD |
denotes |
13,27 |
T10778 |
2542-2543 |
NNP |
denotes |
] |
T10779 |
2543-2544 |
. |
denotes |
. |
T10780 |
2545-2547 |
IN |
denotes |
In |
T10781 |
2548-2552 |
DT |
denotes |
that |
T10782 |
2553-2560 |
NN |
denotes |
respect |
T10783 |
2560-2561 |
, |
denotes |
, |
T10784 |
2562-2566 |
NNS |
denotes |
BMPs |
T10785 |
2567-2571 |
VBP |
denotes |
have |
T10786 |
2572-2576 |
VBN |
denotes |
been |
T10787 |
2577-2582 |
VBN |
denotes |
shown |
T10788 |
2583-2585 |
TO |
denotes |
to |
T10789 |
2586-2591 |
VB |
denotes |
exert |
T10790 |
2592-2609 |
JJ |
denotes |
antiproliferative |
T10791 |
2610-2617 |
NNS |
denotes |
effects |
T10792 |
2618-2620 |
IN |
denotes |
in |
T10793 |
2621-2622 |
NNP |
denotes |
B |
T10794 |
2623-2630 |
NN |
denotes |
lineage |
T10795 |
2631-2636 |
NNS |
denotes |
cells |
T10796 |
2637-2640 |
IN |
denotes |
via |
T10797 |
2641-2656 |
NN |
denotes |
phosphorylation |
T10798 |
2657-2659 |
IN |
denotes |
of |
T10799 |
2660-2666 |
JJ |
denotes |
R-Smad |
T10800 |
2667-2668 |
NNP |
denotes |
[ |
T10801 |
2668-2673 |
CD |
denotes |
11,28 |
T10802 |
2673-2674 |
NNP |
denotes |
] |
T10803 |
2674-2675 |
. |
denotes |
. |
T10804 |
2676-2687 |
RB |
denotes |
Furthermore |
T10805 |
2687-2688 |
, |
denotes |
, |
T10806 |
2689-2694 |
NN |
denotes |
BMP-2 |
T10807 |
2695-2698 |
VBZ |
denotes |
has |
T10808 |
2699-2703 |
VBN |
denotes |
been |
T10809 |
2704-2709 |
VBN |
denotes |
shown |
T10810 |
2710-2712 |
TO |
denotes |
to |
T10811 |
2713-2719 |
VB |
denotes |
induce |
T10812 |
2720-2730 |
NN |
denotes |
activation |
T10813 |
2731-2733 |
IN |
denotes |
of |
T10814 |
2734-2739 |
CD |
denotes |
STAT3 |
T10815 |
2740-2742 |
IN |
denotes |
in |
T10816 |
2743-2750 |
NN |
denotes |
myeloma |
T10817 |
2751-2756 |
NNS |
denotes |
cells |
T10818 |
2757-2758 |
VBP |
denotes |
[ |
T10819 |
2758-2759 |
CD |
denotes |
9 |
T10820 |
2759-2760 |
NNP |
denotes |
] |
T10821 |
2760-2761 |
. |
denotes |
. |
T10822 |
2762-2769 |
RB |
denotes |
However |
T10823 |
2769-2770 |
, |
denotes |
, |
T10824 |
2771-2786 |
NN |
denotes |
phosphorylation |
T10825 |
2787-2789 |
IN |
denotes |
of |
T10826 |
2790-2796 |
NN |
denotes |
R-Smad |
T10827 |
2797-2800 |
VBD |
denotes |
was |
T10828 |
2801-2804 |
RB |
denotes |
not |
T10829 |
2805-2817 |
VBN |
denotes |
investigated |
T10830 |
2818-2820 |
IN |
denotes |
in |
T10831 |
2821-2825 |
DT |
denotes |
that |
T10832 |
2826-2831 |
NN |
denotes |
study |
T10833 |
2831-2832 |
. |
denotes |
. |
T10834 |
2833-2838 |
NN |
denotes |
BMP-2 |
T10835 |
2839-2842 |
VBZ |
denotes |
has |
T10836 |
2843-2847 |
RB |
denotes |
also |
T10837 |
2848-2852 |
VBN |
denotes |
been |
T10838 |
2853-2858 |
VBN |
denotes |
shown |
T10839 |
2859-2861 |
TO |
denotes |
to |
T10840 |
2862-2868 |
VB |
denotes |
induce |
T10841 |
2869-2884 |
NN |
denotes |
phosphorylation |
T10842 |
2885-2887 |
IN |
denotes |
of |
T10843 |
2888-2891 |
CD |
denotes |
p38 |
T10844 |
2892-2893 |
NNP |
denotes |
[ |
T10845 |
2893-2895 |
CD |
denotes |
29 |
T10846 |
2895-2896 |
NNP |
denotes |
] |
T10847 |
2896-2897 |
. |
denotes |
. |
T10848 |
2898-2902 |
RB |
denotes |
Thus |
T10849 |
2902-2903 |
, |
denotes |
, |
T10850 |
2904-2919 |
NN |
denotes |
phosphorylation |
T10851 |
2920-2922 |
IN |
denotes |
of |
T10852 |
2923-2926 |
CD |
denotes |
p38 |
T10853 |
2926-2927 |
, |
denotes |
, |
T10854 |
2928-2933 |
CD |
denotes |
STAT3 |
T10855 |
2934-2937 |
CC |
denotes |
and |
T10856 |
2938-2947 |
CD |
denotes |
Smad1/5/8 |
T10857 |
2948-2957 |
VBP |
denotes |
represent |
T10858 |
2958-2967 |
JJ |
denotes |
important |
T10859 |
2968-2982 |
JJ |
denotes |
BMP-signalling |
T10860 |
2983-2991 |
NNS |
denotes |
pathways |
T10861 |
2992-2996 |
WDT |
denotes |
that |
T10862 |
2997-3005 |
VBD |
denotes |
mediated |
T10863 |
3006-3009 |
DT |
denotes |
the |
T10864 |
3010-3017 |
NNS |
denotes |
effects |
T10865 |
3018-3020 |
IN |
denotes |
of |
T10866 |
3021-3025 |
NNS |
denotes |
BMPs |
T10867 |
3026-3029 |
CC |
denotes |
and |
T10868 |
3030-3034 |
RB |
denotes |
even |
T10869 |
3035-3045 |
JJ |
denotes |
cross-talk |
T10870 |
3046-3053 |
IN |
denotes |
between |
T10871 |
3054-3059 |
DT |
denotes |
these |
T10872 |
3060-3068 |
NNS |
denotes |
pathways |
T10873 |
3069-3072 |
VBZ |
denotes |
has |
T10874 |
3073-3077 |
VBN |
denotes |
been |
T10875 |
3078-3086 |
VBN |
denotes |
reported |
T10876 |
3087-3088 |
NNP |
denotes |
[ |
T10877 |
3088-3093 |
CD |
denotes |
29,30 |
T10878 |
3093-3094 |
NNP |
denotes |
] |
T10879 |
3094-3095 |
. |
denotes |
. |
T10880 |
3096-3098 |
IN |
denotes |
In |
T10881 |
3099-3102 |
DT |
denotes |
the |
T10882 |
3103-3110 |
JJ |
denotes |
present |
T10883 |
3111-3116 |
NN |
denotes |
study |
T10884 |
3116-3117 |
, |
denotes |
, |
T10885 |
3118-3120 |
PRP |
denotes |
we |
T10886 |
3121-3125 |
VBD |
denotes |
were |
T10887 |
3126-3129 |
RB |
denotes |
not |
T10888 |
3130-3134 |
JJ |
denotes |
able |
T10889 |
3135-3137 |
TO |
denotes |
to |
T10890 |
3138-3144 |
VB |
denotes |
detect |
T10891 |
3145-3158 |
JJ |
denotes |
BMP-6-induced |
T10892 |
3159-3166 |
NNS |
denotes |
changes |
T10893 |
3167-3169 |
IN |
denotes |
in |
T10894 |
3170-3173 |
DT |
denotes |
the |
T10895 |
3174-3189 |
NN |
denotes |
phosphorylation |
T10896 |
3190-3196 |
NN |
denotes |
status |
T10897 |
3197-3199 |
IN |
denotes |
of |
T10898 |
3200-3205 |
CD |
denotes |
STAT3 |
T10899 |
3206-3208 |
CC |
denotes |
or |
T10900 |
3209-3212 |
CD |
denotes |
p38 |
T10901 |
3213-3215 |
IN |
denotes |
in |
T10902 |
3216-3221 |
JJ |
denotes |
human |
T10903 |
3222-3232 |
JJ |
denotes |
peripheral |
T10904 |
3233-3234 |
NNP |
denotes |
B |
T10905 |
3235-3240 |
NNS |
denotes |
cells |
T10906 |
3240-3241 |
. |
denotes |
. |
T10907 |
3242-3249 |
RB |
denotes |
Instead |
T10908 |
3249-3250 |
, |
denotes |
, |
T10909 |
3251-3252 |
DT |
denotes |
a |
T10910 |
3253-3258 |
JJ |
denotes |
rapid |
T10911 |
3259-3262 |
CC |
denotes |
and |
T10912 |
3263-3269 |
JJ |
denotes |
marked |
T10913 |
3270-3285 |
NN |
denotes |
phosphorylation |
T10914 |
3286-3288 |
IN |
denotes |
of |
T10915 |
3289-3298 |
NNP |
denotes |
Smad1/5/8 |
T10916 |
3299-3302 |
VBD |
denotes |
was |
T10917 |
3303-3311 |
VBN |
denotes |
revealed |
T10918 |
3311-3312 |
. |
denotes |
. |
T10919 |
3313-3315 |
IN |
denotes |
In |
T10920 |
3316-3317 |
DT |
denotes |
a |
T10921 |
3318-3326 |
JJ |
denotes |
parallel |
T10922 |
3327-3332 |
NN |
denotes |
study |
T10923 |
3332-3333 |
, |
denotes |
, |
T10924 |
3334-3336 |
PRP |
denotes |
we |
T10925 |
3337-3341 |
VBP |
denotes |
have |
T10926 |
3342-3347 |
VBN |
denotes |
found |
T10927 |
3348-3352 |
IN |
denotes |
that |
T10928 |
3353-3358 |
JJ |
denotes |
other |
T10929 |
3359-3363 |
NNS |
denotes |
BMPs |
T10930 |
3364-3368 |
RB |
denotes |
also |
T10931 |
3369-3376 |
VBD |
denotes |
induced |
T10932 |
3377-3392 |
NN |
denotes |
phosphorylation |
T10933 |
3393-3395 |
IN |
denotes |
of |
T10934 |
3396-3405 |
NNP |
denotes |
Smad1/5/8 |
T10935 |
3406-3408 |
IN |
denotes |
in |
T10936 |
3409-3419 |
JJ |
denotes |
peripheral |
T10937 |
3420-3421 |
NNP |
denotes |
B |
T10938 |
3422-3427 |
NNS |
denotes |
cells |
T10939 |
3428-3429 |
-LRB- |
denotes |
( |
T10940 |
3429-3433 |
NNS |
denotes |
data |
T10941 |
3434-3437 |
RB |
denotes |
not |
T10942 |
3438-3443 |
VBN |
denotes |
shown |
T10943 |
3443-3444 |
-RRB- |
denotes |
) |
T10944 |
3444-3445 |
. |
denotes |
. |
T10945 |
3446-3448 |
PRP |
denotes |
We |
T10946 |
3449-3452 |
VBP |
denotes |
are |
T10947 |
3453-3462 |
RB |
denotes |
currently |
T10948 |
3463-3471 |
VBG |
denotes |
pursuing |
T10949 |
3472-3482 |
NN |
denotes |
microarray |
T10950 |
3483-3490 |
NNS |
denotes |
studies |
T10951 |
3491-3493 |
TO |
denotes |
to |
T10952 |
3494-3502 |
VB |
denotes |
identify |
T10953 |
3503-3506 |
DT |
denotes |
the |
T10954 |
3507-3517 |
JJ |
denotes |
signalling |
T10955 |
3518-3526 |
NNS |
denotes |
pathways |
T10956 |
3527-3530 |
CC |
denotes |
and |
T10957 |
3531-3537 |
NN |
denotes |
target |
T10958 |
3538-3543 |
NNS |
denotes |
genes |
T10959 |
3544-3548 |
WDT |
denotes |
that |
T10960 |
3549-3552 |
VBP |
denotes |
are |
T10961 |
3553-3564 |
RB |
denotes |
differently |
T10962 |
3565-3574 |
VBN |
denotes |
regulated |
T10963 |
3575-3577 |
IN |
denotes |
by |
T10964 |
3578-3581 |
DT |
denotes |
the |
T10965 |
3582-3589 |
JJ |
denotes |
various |
T10966 |
3590-3594 |
NNS |
denotes |
BMPs |
T10967 |
3595-3597 |
IN |
denotes |
in |
T10968 |
3598-3603 |
JJ |
denotes |
human |
T10969 |
3604-3605 |
NNP |
denotes |
B |
T10970 |
3606-3611 |
NNS |
denotes |
cells |
T10971 |
3611-3612 |
. |
denotes |
. |
T10972 |
3613-3625 |
NNP |
denotes |
Upregulation |
T10973 |
3626-3628 |
IN |
denotes |
of |
T10974 |
3629-3632 |
NNP |
denotes |
Id1 |
T10975 |
3633-3636 |
IN |
denotes |
via |
T10976 |
3637-3646 |
NNP |
denotes |
Smad1/5/8 |
T10977 |
3647-3662 |
NN |
denotes |
phosphorylation |
T10978 |
3663-3665 |
VBZ |
denotes |
is |
T10979 |
3666-3667 |
DT |
denotes |
a |
T10980 |
3668-3673 |
JJ |
denotes |
known |
T10981 |
3674-3683 |
NN |
denotes |
mechanism |
T10982 |
3684-3687 |
IN |
denotes |
for |
T10983 |
3688-3693 |
NNP |
denotes |
BMP-6 |
T10984 |
3694-3704 |
VBG |
denotes |
signalling |
T10985 |
3705-3707 |
IN |
denotes |
in |
T10986 |
3708-3713 |
JJ |
denotes |
other |
T10987 |
3714-3718 |
NN |
denotes |
cell |
T10988 |
3719-3726 |
NNS |
denotes |
systems |
T10989 |
3727-3728 |
NNP |
denotes |
[ |
T10990 |
3728-3733 |
CD |
denotes |
31,32 |
T10991 |
3733-3734 |
NNP |
denotes |
] |
T10992 |
3735-3738 |
CC |
denotes |
and |
T10993 |
3739-3749 |
NN |
denotes |
regulation |
T10994 |
3750-3752 |
IN |
denotes |
of |
T10995 |
3753-3764 |
NNS |
denotes |
Id-proteins |
T10996 |
3765-3767 |
VBZ |
denotes |
is |
T10997 |
3768-3775 |
VBN |
denotes |
thought |
T10998 |
3776-3778 |
TO |
denotes |
to |
T10999 |
3779-3781 |
VB |
denotes |
be |
T11000 |
3782-3784 |
DT |
denotes |
an |
T11001 |
3785-3794 |
JJ |
denotes |
important |
T11002 |
3795-3804 |
NN |
denotes |
mechanism |
T11003 |
3805-3808 |
IN |
denotes |
for |
T11004 |
3809-3824 |
JJ |
denotes |
Smad-signalling |
T11005 |
3825-3826 |
NNP |
denotes |
[ |
T11006 |
3826-3828 |
CD |
denotes |
17 |
T11007 |
3828-3829 |
NNP |
denotes |
] |
T11008 |
3829-3830 |
. |
denotes |
. |
T11009 |
3831-3833 |
IN |
denotes |
In |
T11010 |
3834-3837 |
DT |
denotes |
the |
T11011 |
3838-3845 |
JJ |
denotes |
present |
T11012 |
3846-3851 |
NN |
denotes |
study |
T11013 |
3851-3852 |
, |
denotes |
, |
T11014 |
3853-3862 |
JJ |
denotes |
real-time |
T11015 |
3863-3869 |
NN |
denotes |
RT-PCR |
T11016 |
3870-3881 |
NNS |
denotes |
experiments |
T11017 |
3882-3890 |
VBD |
denotes |
revealed |
T11018 |
3891-3892 |
DT |
denotes |
a |
T11019 |
3893-3901 |
JJ |
denotes |
specific |
T11020 |
3902-3911 |
RB |
denotes |
four-fold |
T11021 |
3912-3924 |
NN |
denotes |
upregulation |
T11022 |
3925-3928 |
IN |
denotes |
for |
T11023 |
3929-3932 |
NNP |
denotes |
Id1 |
T11024 |
3933-3935 |
IN |
denotes |
in |
T11025 |
3936-3949 |
NNP |
denotes |
BMP-6-treated |
T11026 |
3950-3951 |
NNP |
denotes |
B |
T11027 |
3952-3957 |
NNS |
denotes |
cells |
T11028 |
3957-3958 |
, |
denotes |
, |
T11029 |
3959-3964 |
IN |
denotes |
while |
T11030 |
3965-3968 |
DT |
denotes |
the |
T11031 |
3969-3975 |
NN |
denotes |
amount |
T11032 |
3976-3978 |
IN |
denotes |
of |
T11033 |
3979-3982 |
NNP |
denotes |
Id2 |
T11034 |
3983-3986 |
JJ |
denotes |
Id4 |
T11035 |
3987-3995 |
VBD |
denotes |
remained |
T11036 |
3996-4005 |
JJ |
denotes |
unchanged |
T11037 |
4005-4006 |
. |
denotes |
. |
T11038 |
4007-4009 |
IN |
denotes |
In |
T11039 |
4010-4019 |
NN |
denotes |
agreement |
T11040 |
4020-4024 |
IN |
denotes |
with |
T11041 |
4025-4029 |
DT |
denotes |
this |
T11042 |
4029-4030 |
, |
denotes |
, |
T11043 |
4031-4038 |
JJ |
denotes |
western |
T11044 |
4039-4043 |
NN |
denotes |
blot |
T11045 |
4044-4052 |
NN |
denotes |
analysis |
T11046 |
4053-4065 |
VBD |
denotes |
demonstrated |
T11047 |
4066-4068 |
DT |
denotes |
an |
T11048 |
4069-4081 |
NN |
denotes |
upregulation |
T11049 |
4082-4084 |
IN |
denotes |
of |
T11050 |
4085-4088 |
JJ |
denotes |
Id1 |
T11051 |
4089-4096 |
NN |
denotes |
protein |
T11052 |
4096-4097 |
, |
denotes |
, |
T11053 |
4098-4103 |
IN |
denotes |
while |
T11054 |
4104-4107 |
DT |
denotes |
the |
T11055 |
4108-4114 |
NN |
denotes |
amount |
T11056 |
4115-4117 |
IN |
denotes |
of |
T11057 |
4118-4121 |
NNP |
denotes |
Id2 |
T11058 |
4122-4125 |
CC |
denotes |
and |
T11059 |
4126-4129 |
NNP |
denotes |
Id3 |
T11060 |
4130-4137 |
NN |
denotes |
protein |
T11061 |
4138-4144 |
NNS |
denotes |
levels |
T11062 |
4145-4153 |
VBD |
denotes |
remained |
T11063 |
4154-4163 |
JJ |
denotes |
unchanged |
T11064 |
4163-4164 |
. |
denotes |
. |
T11065 |
4165-4175 |
RB |
denotes |
Previously |
T11066 |
4175-4176 |
, |
denotes |
, |
T11067 |
4177-4180 |
NNP |
denotes |
Id1 |
T11068 |
4181-4184 |
VBZ |
denotes |
has |
T11069 |
4185-4189 |
VBN |
denotes |
been |
T11070 |
4190-4200 |
VBN |
denotes |
considered |
T11071 |
4201-4204 |
RB |
denotes |
not |
T11072 |
4205-4207 |
TO |
denotes |
to |
T11073 |
4208-4210 |
VB |
denotes |
be |
T11074 |
4211-4220 |
VBN |
denotes |
expressed |
T11075 |
4221-4223 |
IN |
denotes |
in |
T11076 |
4224-4229 |
JJ |
denotes |
later |
T11077 |
4230-4243 |
JJ |
denotes |
developmental |
T11078 |
4244-4250 |
NNS |
denotes |
stages |
T11079 |
4251-4255 |
IN |
denotes |
than |
T11080 |
4256-4261 |
JJ |
denotes |
pro-B |
T11081 |
4262-4267 |
NNS |
denotes |
cells |
T11082 |
4268-4269 |
NNP |
denotes |
[ |
T11083 |
4269-4274 |
CD |
denotes |
33,34 |
T11084 |
4274-4275 |
NNP |
denotes |
] |
T11085 |
4275-4276 |
, |
denotes |
, |
T11086 |
4277-4280 |
CC |
denotes |
and |
T11087 |
4281-4284 |
PRP$ |
denotes |
its |
T11088 |
4285-4297 |
JJ |
denotes |
constitutive |
T11089 |
4298-4308 |
NN |
denotes |
expression |
T11090 |
4309-4312 |
VBZ |
denotes |
has |
T11091 |
4313-4317 |
VBN |
denotes |
been |
T11092 |
4318-4326 |
VBN |
denotes |
reported |
T11093 |
4327-4329 |
TO |
denotes |
to |
T11094 |
4330-4336 |
VB |
denotes |
impair |
T11095 |
4337-4342 |
NN |
denotes |
mouse |
T11096 |
4343-4344 |
NNP |
denotes |
B |
T11097 |
4345-4349 |
NN |
denotes |
cell |
T11098 |
4350-4361 |
NN |
denotes |
development |
T11099 |
4362-4363 |
NNP |
denotes |
[ |
T11100 |
4363-4365 |
CD |
denotes |
35 |
T11101 |
4365-4366 |
NNP |
denotes |
] |
T11102 |
4366-4367 |
. |
denotes |
. |
T11103 |
4368-4377 |
RB |
denotes |
Therefore |
T11104 |
4377-4378 |
, |
denotes |
, |
T11105 |
4379-4382 |
PRP$ |
denotes |
our |
T11106 |
4383-4396 |
NN |
denotes |
demonstration |
T11107 |
4397-4399 |
IN |
denotes |
of |
T11108 |
4400-4403 |
DT |
denotes |
the |
T11109 |
4404-4418 |
JJ |
denotes |
time-dependent |
T11110 |
4419-4431 |
NN |
denotes |
upregulation |
T11111 |
4432-4434 |
IN |
denotes |
of |
T11112 |
4435-4438 |
NNP |
denotes |
Id1 |
T11113 |
4439-4443 |
NNP |
denotes |
mRNA |
T11114 |
4444-4447 |
CC |
denotes |
and |
T11115 |
4448-4455 |
NN |
denotes |
protein |
T11116 |
4456-4458 |
IN |
denotes |
in |
T11117 |
4459-4465 |
JJ |
denotes |
mature |
T11118 |
4466-4472 |
JJ |
denotes |
normal |
T11119 |
4473-4478 |
JJ |
denotes |
human |
T11120 |
4479-4480 |
NNP |
denotes |
B |
T11121 |
4481-4486 |
NNS |
denotes |
cells |
T11122 |
4487-4489 |
VBZ |
denotes |
is |
T11123 |
4490-4492 |
IN |
denotes |
of |
T11124 |
4493-4503 |
JJ |
denotes |
particular |
T11125 |
4504-4512 |
NN |
denotes |
interest |
T11126 |
4512-4513 |
. |
denotes |
. |
T11127 |
4514-4516 |
IN |
denotes |
In |
T11128 |
4517-4521 |
DT |
denotes |
that |
T11129 |
4522-4529 |
NN |
denotes |
respect |
T11130 |
4529-4530 |
, |
denotes |
, |
T11131 |
4531-4533 |
PRP |
denotes |
it |
T11132 |
4534-4536 |
VBZ |
denotes |
is |
T11133 |
4537-4547 |
JJ |
denotes |
noteworthy |
T11134 |
4548-4552 |
IN |
denotes |
that |
T11135 |
4553-4558 |
JJ |
denotes |
TGF-β |
T11136 |
4559-4569 |
NN |
denotes |
signalling |
T11137 |
4570-4572 |
IN |
denotes |
in |
T11138 |
4573-4578 |
JJ |
denotes |
early |
T11139 |
4579-4582 |
CC |
denotes |
and |
T11140 |
4583-4589 |
JJ |
denotes |
mature |
T11141 |
4590-4591 |
NNP |
denotes |
B |
T11142 |
4592-4597 |
NNS |
denotes |
cells |
T11143 |
4598-4605 |
VBZ |
denotes |
induces |
T11144 |
4606-4610 |
DT |
denotes |
both |
T11145 |
4611-4614 |
JJ |
denotes |
Id2 |
T11146 |
4615-4618 |
CC |
denotes |
and |
T11147 |
4619-4622 |
JJ |
denotes |
Id3 |
T11148 |
4623-4633 |
NN |
denotes |
expression |
T11149 |
4634-4635 |
NNP |
denotes |
[ |
T11150 |
4635-4640 |
CD |
denotes |
36,37 |
T11151 |
4640-4641 |
NNP |
denotes |
] |
T11152 |
4641-4642 |
, |
denotes |
, |
T11153 |
4643-4646 |
CC |
denotes |
but |
T11154 |
4647-4650 |
RB |
denotes |
not |
T11155 |
4651-4654 |
JJ |
denotes |
Id1 |
T11156 |
4655-4656 |
-LRB- |
denotes |
( |
T11157 |
4656-4660 |
NNS |
denotes |
data |
T11158 |
4661-4664 |
RB |
denotes |
not |
T11159 |
4665-4670 |
VBN |
denotes |
shown |
T11160 |
4670-4671 |
-RRB- |
denotes |
) |
T11161 |
4671-4672 |
. |
denotes |
. |
T11162 |
4673-4686 |
RB |
denotes |
Interestingly |
T11163 |
4686-4687 |
, |
denotes |
, |
T11164 |
4688-4693 |
DT |
denotes |
these |
T11165 |
4694-4701 |
NNS |
denotes |
results |
T11166 |
4702-4706 |
VBP |
denotes |
show |
T11167 |
4707-4711 |
IN |
denotes |
that |
T11168 |
4712-4719 |
JJ |
denotes |
various |
T11169 |
4720-4727 |
NNS |
denotes |
members |
T11170 |
4728-4730 |
IN |
denotes |
of |
T11171 |
4731-4734 |
DT |
denotes |
the |
T11172 |
4735-4740 |
NNP |
denotes |
TGF-β |
T11173 |
4741-4747 |
NN |
denotes |
family |
T11174 |
4748-4756 |
VB |
denotes |
regulate |
T11175 |
4757-4759 |
NN |
denotes |
Id |
T11176 |
4760-4768 |
NNS |
denotes |
proteins |
T11177 |
4769-4780 |
RB |
denotes |
differently |
T11178 |
4780-4781 |
. |
denotes |
. |
T11179 |
4782-4785 |
NNP |
denotes |
Id2 |
T11180 |
4786-4789 |
CC |
denotes |
and |
T11181 |
4790-4793 |
NNP |
denotes |
Id3 |
T11182 |
4794-4797 |
VBP |
denotes |
are |
T11183 |
4798-4808 |
VBN |
denotes |
considered |
T11184 |
4809-4811 |
TO |
denotes |
to |
T11185 |
4812-4814 |
VB |
denotes |
be |
T11186 |
4815-4818 |
DT |
denotes |
the |
T11187 |
4819-4821 |
NN |
denotes |
Id |
T11188 |
4822-4830 |
VBZ |
denotes |
proteins |
T11189 |
4831-4837 |
RB |
denotes |
mainly |
T11190 |
4838-4847 |
VBN |
denotes |
expressed |
T11191 |
4848-4850 |
IN |
denotes |
in |
T11192 |
4851-4857 |
JJ |
denotes |
mature |
T11193 |
4858-4859 |
NNP |
denotes |
B |
T11194 |
4860-4865 |
NNS |
denotes |
cells |
T11195 |
4866-4867 |
NNP |
denotes |
[ |
T11196 |
4867-4869 |
CD |
denotes |
38 |
T11197 |
4869-4870 |
NNP |
denotes |
] |
T11198 |
4870-4871 |
. |
denotes |
. |
T11199 |
4872-4875 |
DT |
denotes |
The |
T11200 |
4876-4883 |
JJ |
denotes |
present |
T11201 |
4884-4889 |
NN |
denotes |
study |
T11202 |
4890-4894 |
RB |
denotes |
also |
T11203 |
4895-4900 |
VBD |
denotes |
found |
T11204 |
4901-4904 |
NNP |
denotes |
Id2 |
T11205 |
4905-4908 |
CC |
denotes |
and |
T11206 |
4909-4912 |
NNP |
denotes |
Id3 |
T11207 |
4913-4920 |
NN |
denotes |
protein |
T11208 |
4921-4923 |
IN |
denotes |
in |
T11209 |
4924-4925 |
NNP |
denotes |
B |
T11210 |
4926-4931 |
NNS |
denotes |
cells |
T11211 |
4932-4934 |
TO |
denotes |
to |
T11212 |
4935-4937 |
VB |
denotes |
be |
T11213 |
4938-4942 |
RBR |
denotes |
more |
T11214 |
4943-4949 |
RB |
denotes |
highly |
T11215 |
4950-4959 |
VBN |
denotes |
expressed |
T11216 |
4960-4964 |
IN |
denotes |
than |
T11217 |
4965-4968 |
JJ |
denotes |
Id1 |
T11218 |
4969-4971 |
IN |
denotes |
in |
T11219 |
4972-4979 |
VBG |
denotes |
resting |
T11220 |
4980-4981 |
NNP |
denotes |
B |
T11221 |
4982-4987 |
NNS |
denotes |
cells |
T11222 |
4987-4988 |
. |
denotes |
. |
T11223 |
4989-4996 |
RB |
denotes |
However |
T11224 |
4996-4997 |
, |
denotes |
, |
T11225 |
4998-5003 |
NNP |
denotes |
BMP-6 |
T11226 |
5004-5007 |
VBD |
denotes |
did |
T11227 |
5008-5011 |
RB |
denotes |
not |
T11228 |
5012-5018 |
VB |
denotes |
induce |
T11229 |
5019-5030 |
JJ |
denotes |
significant |
T11230 |
5031-5038 |
NNS |
denotes |
changes |
T11231 |
5039-5041 |
IN |
denotes |
in |
T11232 |
5042-5045 |
DT |
denotes |
the |
T11233 |
5046-5053 |
NN |
denotes |
protein |
T11234 |
5054-5064 |
NN |
denotes |
expression |
T11235 |
5065-5067 |
IN |
denotes |
of |
T11236 |
5068-5071 |
NNP |
denotes |
Id2 |
T11237 |
5072-5075 |
CC |
denotes |
and |
T11238 |
5076-5079 |
NNP |
denotes |
Id3 |
T11239 |
5079-5080 |
. |
denotes |
. |
T11240 |
5081-5083 |
PRP |
denotes |
It |
T11241 |
5084-5086 |
VBZ |
denotes |
is |
T11242 |
5087-5095 |
VBN |
denotes |
believed |
T11243 |
5096-5100 |
IN |
denotes |
that |
T11244 |
5101-5103 |
NN |
denotes |
Id |
T11245 |
5104-5112 |
NNS |
denotes |
proteins |
T11246 |
5113-5118 |
VBP |
denotes |
block |
T11247 |
5119-5134 |
NN |
denotes |
differentiation |
T11248 |
5135-5138 |
CC |
denotes |
and |
T11249 |
5139-5146 |
VB |
denotes |
promote |
T11250 |
5147-5160 |
NN |
denotes |
proliferation |
T11251 |
5161-5163 |
IN |
denotes |
in |
T11252 |
5164-5171 |
JJ |
denotes |
various |
T11253 |
5172-5176 |
NN |
denotes |
cell |
T11254 |
5177-5182 |
NNS |
denotes |
types |
T11255 |
5183-5184 |
NNP |
denotes |
[ |
T11256 |
5184-5189 |
CD |
denotes |
39,33 |
T11257 |
5189-5190 |
NNP |
denotes |
] |
T11258 |
5190-5191 |
. |
denotes |
. |
T11259 |
5192-5194 |
NN |
denotes |
Id |
T11260 |
5195-5203 |
NNS |
denotes |
proteins |
T11261 |
5204-5207 |
VBP |
denotes |
act |
T11262 |
5208-5210 |
IN |
denotes |
as |
T11263 |
5211-5228 |
JJ |
denotes |
dominant-negative |
T11264 |
5229-5239 |
NNS |
denotes |
inhibitors |
T11265 |
5240-5242 |
IN |
denotes |
of |
T11266 |
5243-5253 |
NNS |
denotes |
E-proteins |
T11267 |
5254-5257 |
CC |
denotes |
and |
T11268 |
5258-5262 |
NNS |
denotes |
Pax5 |
T11269 |
5263-5271 |
NN |
denotes |
function |
T11270 |
5272-5274 |
IN |
denotes |
by |
T11271 |
5275-5282 |
VBG |
denotes |
forming |
T11272 |
5283-5289 |
NNS |
denotes |
dimers |
T11273 |
5290-5294 |
IN |
denotes |
with |
T11274 |
5295-5300 |
DT |
denotes |
these |
T11275 |
5301-5309 |
NNS |
denotes |
proteins |
T11276 |
5309-5310 |
, |
denotes |
, |
T11277 |
5311-5317 |
VBG |
denotes |
making |
T11278 |
5318-5322 |
PRP |
denotes |
them |
T11279 |
5323-5329 |
JJ |
denotes |
unable |
T11280 |
5330-5332 |
TO |
denotes |
to |
T11281 |
5333-5337 |
NN |
denotes |
bind |
T11282 |
5338-5341 |
NN |
denotes |
DNA |
T11283 |
5341-5342 |
. |
denotes |
. |
T11284 |
5343-5345 |
PRP |
denotes |
It |
T11285 |
5346-5349 |
VBZ |
denotes |
has |
T11286 |
5350-5354 |
VBN |
denotes |
been |
T11287 |
5355-5363 |
VBN |
denotes |
proposed |
T11288 |
5364-5368 |
IN |
denotes |
that |
T11289 |
5369-5372 |
DT |
denotes |
the |
T11290 |
5373-5380 |
NN |
denotes |
balance |
T11291 |
5381-5386 |
IN |
denotes |
among |
T11292 |
5387-5397 |
NNS |
denotes |
E-proteins |
T11293 |
5397-5398 |
, |
denotes |
, |
T11294 |
5399-5403 |
NNS |
denotes |
Pax5 |
T11295 |
5404-5407 |
CC |
denotes |
and |
T11296 |
5408-5410 |
NN |
denotes |
Id |
T11297 |
5411-5419 |
NNS |
denotes |
proteins |
T11298 |
5420-5425 |
MD |
denotes |
might |
T11299 |
5426-5430 |
VB |
denotes |
have |
T11300 |
5431-5433 |
DT |
denotes |
an |
T11301 |
5434-5443 |
JJ |
denotes |
important |
T11302 |
5444-5448 |
NN |
denotes |
role |
T11303 |
5449-5451 |
IN |
denotes |
in |
T11304 |
5452-5461 |
VBN |
denotes |
activated |
T11305 |
5462-5463 |
NNP |
denotes |
B |
T11306 |
5464-5469 |
NNS |
denotes |
cells |
T11307 |
5470-5471 |
NNP |
denotes |
[ |
T11308 |
5471-5473 |
CD |
denotes |
38 |
T11309 |
5473-5474 |
NNP |
denotes |
] |
T11310 |
5474-5475 |
. |
denotes |
. |
T11311 |
5476-5478 |
IN |
denotes |
In |
T11312 |
5479-5483 |
DT |
denotes |
that |
T11313 |
5484-5491 |
NN |
denotes |
respect |
T11314 |
5491-5492 |
, |
denotes |
, |
T11315 |
5493-5503 |
NNS |
denotes |
E-proteins |
T11316 |
5504-5508 |
VBP |
denotes |
have |
T11317 |
5509-5513 |
VBN |
denotes |
been |
T11318 |
5514-5524 |
VBN |
denotes |
implicated |
T11319 |
5525-5527 |
IN |
denotes |
in |
T11320 |
5528-5532 |
DT |
denotes |
both |
T11321 |
5533-5536 |
DT |
denotes |
the |
T11322 |
5537-5546 |
NN |
denotes |
promotion |
T11323 |
5547-5550 |
CC |
denotes |
and |
T11324 |
5551-5561 |
NN |
denotes |
inhibition |
T11325 |
5562-5564 |
IN |
denotes |
of |
T11326 |
5565-5569 |
NN |
denotes |
cell |
T11327 |
5570-5578 |
NN |
denotes |
survival |
T11328 |
5579-5582 |
CC |
denotes |
and |
T11329 |
5583-5589 |
NN |
denotes |
growth |
T11330 |
5590-5592 |
IN |
denotes |
at |
T11331 |
5593-5602 |
JJ |
denotes |
different |
T11332 |
5603-5609 |
NNS |
denotes |
points |
T11333 |
5610-5612 |
IN |
denotes |
in |
T11334 |
5613-5623 |
NN |
denotes |
lymphocyte |
T11335 |
5624-5635 |
NN |
denotes |
development |
T11336 |
5636-5637 |
NNP |
denotes |
[ |
T11337 |
5637-5639 |
CD |
denotes |
40 |
T11338 |
5639-5640 |
NNP |
denotes |
] |
T11339 |
5640-5641 |
. |
denotes |
. |
T11340 |
5642-5645 |
DT |
denotes |
The |
T11341 |
5646-5663 |
JJ |
denotes |
antiproliferative |
T11342 |
5664-5667 |
CC |
denotes |
and |
T11343 |
5668-5673 |
NN |
denotes |
death |
T11344 |
5674-5682 |
VBG |
denotes |
inducing |
T11345 |
5683-5689 |
NN |
denotes |
effect |
T11346 |
5690-5692 |
IN |
denotes |
of |
T11347 |
5693-5698 |
NN |
denotes |
BMP-6 |
T11348 |
5699-5701 |
IN |
denotes |
in |
T11349 |
5702-5703 |
NNP |
denotes |
B |
T11350 |
5704-5709 |
NNS |
denotes |
cells |
T11351 |
5710-5714 |
IN |
denotes |
with |
T11352 |
5715-5726 |
JJ |
denotes |
concomitant |
T11353 |
5727-5739 |
NN |
denotes |
upregulation |
T11354 |
5740-5742 |
IN |
denotes |
of |
T11355 |
5743-5746 |
JJ |
denotes |
Id1 |
T11356 |
5747-5754 |
NN |
denotes |
protein |
T11357 |
5755-5757 |
VBZ |
denotes |
is |
T11358 |
5758-5767 |
RB |
denotes |
therefore |
T11359 |
5768-5770 |
IN |
denotes |
in |
T11360 |
5771-5775 |
NN |
denotes |
line |
T11361 |
5776-5780 |
IN |
denotes |
with |
T11362 |
5781-5784 |
DT |
denotes |
the |
T11363 |
5785-5789 |
NN |
denotes |
view |
T11364 |
5790-5794 |
IN |
denotes |
that |
T11365 |
5795-5797 |
NN |
denotes |
Id |
T11366 |
5798-5806 |
NNS |
denotes |
proteins |
T11367 |
5807-5810 |
VBP |
denotes |
are |
T11368 |
5811-5819 |
VBN |
denotes |
required |
T11369 |
5820-5823 |
IN |
denotes |
for |
T11370 |
5824-5827 |
DT |
denotes |
the |
T11371 |
5828-5837 |
NN |
denotes |
induction |
T11372 |
5838-5840 |
IN |
denotes |
of |
T11373 |
5841-5847 |
NN |
denotes |
growth |
T11374 |
5848-5854 |
NN |
denotes |
arrest |
T11375 |
5855-5858 |
CC |
denotes |
and |
T11376 |
5859-5868 |
NN |
denotes |
apoptosis |
T11377 |
5869-5871 |
IN |
denotes |
in |
T11378 |
5872-5884 |
JJ |
denotes |
B-lymphocyte |
T11379 |
5885-5896 |
NNS |
denotes |
progenitors |
T11380 |
5897-5899 |
IN |
denotes |
by |
T11381 |
5900-5905 |
NNP |
denotes |
TGF-β |
T11382 |
5906-5907 |
NNP |
denotes |
[ |
T11383 |
5907-5909 |
CD |
denotes |
40 |
T11384 |
5909-5910 |
NNP |
denotes |
] |
T11385 |
5910-5911 |
. |
denotes |
. |
T11386 |
5912-5923 |
RB |
denotes |
Furthermore |
T11387 |
5923-5924 |
, |
denotes |
, |
T11388 |
5925-5927 |
NN |
denotes |
Id |
T11389 |
5928-5936 |
NNS |
denotes |
proteins |
T11390 |
5937-5940 |
VBP |
denotes |
are |
T11391 |
5941-5946 |
VBN |
denotes |
known |
T11392 |
5947-5949 |
IN |
denotes |
as |
T11393 |
5950-5959 |
JJ |
denotes |
important |
T11394 |
5960-5965 |
NNS |
denotes |
parts |
T11395 |
5966-5968 |
IN |
denotes |
of |
T11396 |
5969-5979 |
VBG |
denotes |
signalling |
T11397 |
5980-5988 |
NNS |
denotes |
pathways |
T11398 |
5989-5997 |
VBN |
denotes |
involved |
T11399 |
5998-6000 |
IN |
denotes |
in |
T11400 |
6001-6012 |
NN |
denotes |
development |
T11401 |
6012-6013 |
, |
denotes |
, |
T11402 |
6014-6018 |
NN |
denotes |
cell |
T11403 |
6019-6024 |
NN |
denotes |
cycle |
T11404 |
6025-6028 |
CC |
denotes |
and |
T11405 |
6029-6042 |
NN |
denotes |
tumorigenesis |
T11406 |
6043-6044 |
NNP |
denotes |
[ |
T11407 |
6044-6046 |
CD |
denotes |
32 |
T11408 |
6046-6047 |
NNP |
denotes |
] |
T11409 |
6047-6048 |
. |
denotes |
. |
T11410 |
6049-6051 |
PRP |
denotes |
It |
T11411 |
6052-6054 |
VBZ |
denotes |
is |
T11412 |
6055-6059 |
RB |
denotes |
well |
T11413 |
6060-6071 |
VBN |
denotes |
established |
T11414 |
6072-6076 |
IN |
denotes |
that |
T11415 |
6077-6084 |
JJ |
denotes |
various |
T11416 |
6085-6092 |
NNS |
denotes |
members |
T11417 |
6093-6095 |
IN |
denotes |
of |
T11418 |
6096-6099 |
DT |
denotes |
the |
T11419 |
6100-6102 |
NN |
denotes |
Id |
T11420 |
6103-6109 |
NN |
denotes |
family |
T11421 |
6110-6113 |
VBP |
denotes |
are |
T11422 |
6114-6127 |
VBN |
denotes |
overexpressed |
T11423 |
6128-6130 |
IN |
denotes |
in |
T11424 |
6131-6132 |
DT |
denotes |
a |
T11425 |
6133-6138 |
NN |
denotes |
range |
T11426 |
6139-6141 |
IN |
denotes |
of |
T11427 |
6142-6147 |
JJ |
denotes |
human |
T11428 |
6148-6155 |
NNS |
denotes |
tumours |
T11429 |
6156-6159 |
CC |
denotes |
and |
T11430 |
6160-6169 |
RB |
denotes |
generally |
T11431 |
6169-6170 |
, |
denotes |
, |
T11432 |
6171-6174 |
JJ |
denotes |
Id1 |
T11433 |
6175-6182 |
VBZ |
denotes |
appears |
T11434 |
6183-6185 |
TO |
denotes |
to |
T11435 |
6186-6188 |
VB |
denotes |
be |
T11436 |
6189-6192 |
DT |
denotes |
the |
T11437 |
6193-6199 |
NN |
denotes |
family |
T11438 |
6200-6206 |
NN |
denotes |
member |
T11439 |
6207-6211 |
RBS |
denotes |
most |
T11440 |
6212-6218 |
RB |
denotes |
widely |
T11441 |
6219-6232 |
VBN |
denotes |
overexpressed |
T11442 |
6233-6235 |
IN |
denotes |
in |
T11443 |
6236-6237 |
DT |
denotes |
a |
T11444 |
6238-6245 |
NN |
denotes |
variety |
T11445 |
6246-6248 |
IN |
denotes |
of |
T11446 |
6249-6254 |
JJ |
denotes |
human |
T11447 |
6255-6267 |
NNS |
denotes |
malignancies |
T11448 |
6268-6269 |
NNP |
denotes |
[ |
T11449 |
6269-6271 |
CD |
denotes |
41 |
T11450 |
6271-6272 |
NNP |
denotes |
] |
T11451 |
6272-6273 |
, |
denotes |
, |
T11452 |
6274-6283 |
VBG |
denotes |
including |
T11453 |
6284-6292 |
JJ |
denotes |
multiple |
T11454 |
6293-6300 |
NN |
denotes |
myeloma |
T11455 |
6301-6302 |
NNP |
denotes |
[ |
T11456 |
6302-6307 |
CD |
denotes |
42,32 |
T11457 |
6307-6308 |
NNP |
denotes |
] |
T11458 |
6308-6309 |
. |
denotes |
. |
T11459 |
6310-6322 |
RB |
denotes |
Additionally |
T11460 |
6322-6323 |
, |
denotes |
, |
T11461 |
6324-6327 |
PRP$ |
denotes |
our |
T11462 |
6328-6336 |
NNS |
denotes |
findings |
T11463 |
6337-6341 |
WDT |
denotes |
that |
T11464 |
6342-6347 |
NNP |
denotes |
BMP-6 |
T11465 |
6348-6357 |
VBZ |
denotes |
activates |
T11466 |
6358-6371 |
JJ |
denotes |
intracellular |
T11467 |
6372-6382 |
JJ |
denotes |
signalling |
T11468 |
6383-6391 |
NNS |
denotes |
pathways |
T11469 |
6392-6394 |
IN |
denotes |
in |
T11470 |
6395-6400 |
JJ |
denotes |
human |
T11471 |
6401-6402 |
NNP |
denotes |
B |
T11472 |
6403-6408 |
NNS |
denotes |
cells |
T11473 |
6409-6414 |
MD |
denotes |
might |
T11474 |
6415-6417 |
VB |
denotes |
be |
T11475 |
6418-6420 |
IN |
denotes |
of |
T11476 |
6421-6430 |
JJ |
denotes |
potential |
T11477 |
6431-6449 |
JJ |
denotes |
pathophysiological |
T11478 |
6450-6462 |
NN |
denotes |
significance |
T11479 |
6463-6465 |
IN |
denotes |
in |
T11480 |
6466-6474 |
NN |
denotes |
lymphoma |
T11481 |
6475-6478 |
CC |
denotes |
and |
T11482 |
6479-6491 |
NN |
denotes |
inflammation |
T11483 |
6491-6492 |
. |
denotes |
. |
T11484 |
6493-6497 |
NNP |
denotes |
High |
T11485 |
6498-6503 |
NNP |
denotes |
BMP-6 |
T11486 |
6504-6508 |
NNP |
denotes |
mRNA |
T11487 |
6509-6519 |
NN |
denotes |
expression |
T11488 |
6520-6522 |
IN |
denotes |
in |
T11489 |
6523-6528 |
NNP |
denotes |
DLBCL |
T11490 |
6529-6532 |
VBZ |
denotes |
has |
T11491 |
6533-6537 |
VBN |
denotes |
been |
T11492 |
6538-6543 |
VBN |
denotes |
shown |
T11493 |
6544-6546 |
TO |
denotes |
to |
T11494 |
6547-6556 |
VB |
denotes |
correlate |
T11495 |
6557-6559 |
TO |
denotes |
to |
T11496 |
6560-6572 |
JJ |
denotes |
unfavourable |
T11497 |
6573-6580 |
NN |
denotes |
outcome |
T11498 |
6581-6582 |
NNP |
denotes |
[ |
T11499 |
6582-6584 |
CD |
denotes |
12 |
T11500 |
6584-6585 |
NNP |
denotes |
] |
T11501 |
6585-6586 |
. |
denotes |
. |
T11502 |
6587-6589 |
IN |
denotes |
In |
T11503 |
6590-6594 |
DT |
denotes |
this |
T11504 |
6595-6602 |
NN |
denotes |
respect |
T11505 |
6602-6603 |
, |
denotes |
, |
T11506 |
6604-6606 |
PRP |
denotes |
it |
T11507 |
6607-6609 |
VBZ |
denotes |
is |
T11508 |
6610-6612 |
IN |
denotes |
of |
T11509 |
6613-6621 |
NN |
denotes |
interest |
T11510 |
6622-6626 |
IN |
denotes |
that |
T11511 |
6627-6635 |
JJ |
denotes |
targeted |
T11512 |
6636-6646 |
NN |
denotes |
expression |
T11513 |
6647-6649 |
IN |
denotes |
of |
T11514 |
6650-6653 |
NNP |
denotes |
Id1 |
T11515 |
6654-6656 |
TO |
denotes |
to |
T11516 |
6657-6670 |
NNS |
denotes |
B-lymphocytes |
T11517 |
6671-6679 |
VBD |
denotes |
resulted |
T11518 |
6680-6682 |
IN |
denotes |
in |
T11519 |
6683-6691 |
JJ |
denotes |
aberrant |
T11520 |
6692-6693 |
NNP |
denotes |
B |
T11521 |
6694-6698 |
NN |
denotes |
cell |
T11522 |
6699-6710 |
NN |
denotes |
development |
T11523 |
6710-6711 |
, |
denotes |
, |
T11524 |
6712-6719 |
JJ |
denotes |
massive |
T11525 |
6720-6729 |
NN |
denotes |
apoptosis |
T11526 |
6729-6730 |
, |
denotes |
, |
T11527 |
6731-6734 |
CC |
denotes |
and |
T11528 |
6735-6745 |
JJ |
denotes |
subsequent |
T11529 |
6746-6757 |
NN |
denotes |
development |
T11530 |
6758-6760 |
IN |
denotes |
of |
T11531 |
6761-6762 |
NNP |
denotes |
B |
T11532 |
6763-6767 |
NN |
denotes |
cell |
T11533 |
6768-6777 |
NNS |
denotes |
lymphomas |
T11534 |
6778-6779 |
NNP |
denotes |
[ |
T11535 |
6779-6781 |
CD |
denotes |
35 |
T11536 |
6781-6782 |
NNP |
denotes |
] |
T11537 |
6782-6783 |
. |
denotes |
. |
T11538 |
6784-6792 |
RB |
denotes |
Moreover |
T11539 |
6792-6793 |
, |
denotes |
, |
T11540 |
6794-6799 |
NNP |
denotes |
BMP-6 |
T11541 |
6800-6803 |
VBZ |
denotes |
has |
T11542 |
6804-6808 |
VBN |
denotes |
been |
T11543 |
6809-6818 |
VBN |
denotes |
suggested |
T11544 |
6819-6821 |
TO |
denotes |
to |
T11545 |
6822-6826 |
VB |
denotes |
play |
T11546 |
6827-6828 |
DT |
denotes |
a |
T11547 |
6829-6833 |
NN |
denotes |
role |
T11548 |
6834-6836 |
IN |
denotes |
in |
T11549 |
6837-6847 |
JJ |
denotes |
rheumatoid |
T11550 |
6848-6857 |
NNS |
denotes |
arthritis |
T11551 |
6858-6859 |
-LRB- |
denotes |
( |
T11552 |
6859-6861 |
NNP |
denotes |
RA |
T11553 |
6861-6862 |
-RRB- |
denotes |
) |
T11554 |
6863-6864 |
NNP |
denotes |
[ |
T11555 |
6864-6869 |
CD |
denotes |
43,44 |
T11556 |
6869-6870 |
NNP |
denotes |
] |
T11557 |
6871-6874 |
CC |
denotes |
and |
T11558 |
6875-6883 |
JJ |
denotes |
elevated |
T11559 |
6884-6890 |
NNS |
denotes |
levels |
T11560 |
6891-6893 |
IN |
denotes |
of |
T11561 |
6894-6897 |
NNP |
denotes |
Id1 |
T11562 |
6898-6901 |
CC |
denotes |
and |
T11563 |
6902-6905 |
NNP |
denotes |
Id3 |
T11564 |
6906-6910 |
VBP |
denotes |
have |
T11565 |
6911-6915 |
VBN |
denotes |
been |
T11566 |
6916-6921 |
VBN |
denotes |
found |
T11567 |
6922-6924 |
IN |
denotes |
in |
T11568 |
6925-6928 |
DT |
denotes |
the |
T11569 |
6929-6936 |
NN |
denotes |
synovia |
T11570 |
6937-6939 |
IN |
denotes |
of |
T11571 |
6940-6951 |
NNS |
denotes |
RA-patients |
T11572 |
6952-6953 |
NNP |
denotes |
[ |
T11573 |
6953-6955 |
CD |
denotes |
45 |
T11574 |
6955-6956 |
NNP |
denotes |
] |
T11575 |
6956-6957 |
. |
denotes |
. |
T11576 |
6958-6968 |
RB |
denotes |
Altogether |
T11577 |
6968-6969 |
, |
denotes |
, |
T11578 |
6970-6975 |
DT |
denotes |
these |
T11579 |
6976-6983 |
NNS |
denotes |
results |
T11580 |
6984-6989 |
NN |
denotes |
point |
T11581 |
6990-6992 |
TO |
denotes |
to |
T11582 |
6993-6995 |
DT |
denotes |
an |
T11583 |
6996-7005 |
JJ |
denotes |
important |
T11584 |
7006-7010 |
NN |
denotes |
role |
T11585 |
7011-7014 |
IN |
denotes |
for |
T11586 |
7015-7017 |
NN |
denotes |
Id |
T11587 |
7018-7026 |
NNS |
denotes |
proteins |
T11588 |
7027-7029 |
IN |
denotes |
in |
T11589 |
7030-7033 |
DT |
denotes |
the |
T11590 |
7034-7044 |
NN |
denotes |
regulation |
T11591 |
7045-7047 |
IN |
denotes |
of |
T11592 |
7048-7054 |
JJ |
denotes |
normal |
T11593 |
7055-7056 |
NNP |
denotes |
B |
T11594 |
7057-7061 |
NN |
denotes |
cell |
T11595 |
7062-7073 |
NN |
denotes |
homeostasis |
T11596 |
7074-7077 |
CC |
denotes |
and |
T11597 |
7078-7080 |
IN |
denotes |
in |
T11598 |
7081-7089 |
NNS |
denotes |
diseases |
T11599 |
7089-7090 |
, |
denotes |
, |
T11600 |
7091-7096 |
WRB |
denotes |
where |
T11601 |
7097-7098 |
NNP |
denotes |
B |
T11602 |
7099-7104 |
NNS |
denotes |
cells |
T11603 |
7105-7108 |
VBP |
denotes |
are |
T11604 |
7109-7117 |
VBN |
denotes |
involved |
T11605 |
7117-7118 |
. |
denotes |
. |
T11606 |
7119-7121 |
PRP |
denotes |
It |
T11607 |
7122-7126 |
MD |
denotes |
will |
T11608 |
7127-7136 |
RB |
denotes |
therefore |
T11609 |
7137-7139 |
VB |
denotes |
be |
T11610 |
7140-7149 |
JJ |
denotes |
important |
T11611 |
7150-7152 |
TO |
denotes |
to |
T11612 |
7153-7160 |
RBR |
denotes |
further |
T11613 |
7161-7170 |
VB |
denotes |
elucidate |
T11614 |
7171-7174 |
DT |
denotes |
the |
T11615 |
7175-7179 |
NN |
denotes |
role |
T11616 |
7180-7182 |
IN |
denotes |
of |
T11617 |
7183-7187 |
NN |
denotes |
Id-1 |
T11618 |
7188-7190 |
IN |
denotes |
in |
T11619 |
7191-7196 |
JJ |
denotes |
human |
T11620 |
7197-7198 |
NNP |
denotes |
B |
T11621 |
7199-7204 |
NNS |
denotes |
cells |
T11622 |
7205-7207 |
IN |
denotes |
by |
T11623 |
7208-7217 |
JJ |
denotes |
selective |
T11624 |
7218-7222 |
IN |
denotes |
over |
T11625 |
7223-7233 |
NN |
denotes |
expression |
T11626 |
7234-7236 |
CC |
denotes |
or |
T11627 |
7237-7247 |
NN |
denotes |
inhibition |
T11628 |
7248-7250 |
IN |
denotes |
of |
T11629 |
7251-7255 |
JJ |
denotes |
Id-1 |
T11630 |
7256-7260 |
NN |
denotes |
gene |
T11631 |
7261-7271 |
NN |
denotes |
expression |
T11632 |
7271-7272 |
. |
denotes |
. |
T11633 |
7273-7278 |
VBN |
denotes |
Given |
T11634 |
7279-7282 |
DT |
denotes |
the |
T11635 |
7283-7287 |
NN |
denotes |
role |
T11636 |
7288-7290 |
IN |
denotes |
of |
T11637 |
7291-7296 |
NNP |
denotes |
BMP-6 |
T11638 |
7297-7299 |
IN |
denotes |
in |
T11639 |
7300-7306 |
NNP |
denotes |
mature |
T11640 |
7307-7312 |
JJ |
denotes |
human |
T11641 |
7313-7314 |
NNP |
denotes |
B |
T11642 |
7315-7320 |
NNS |
denotes |
cells |
T11643 |
7321-7333 |
VBD |
denotes |
demonstrated |
T11644 |
7334-7338 |
RB |
denotes |
here |
T11645 |
7338-7339 |
, |
denotes |
, |
T11646 |
7340-7354 |
NN |
denotes |
identification |
T11647 |
7355-7357 |
IN |
denotes |
of |
T11648 |
7358-7363 |
NNP |
denotes |
BMP-6 |
T11649 |
7364-7373 |
VBG |
denotes |
producing |
T11650 |
7374-7379 |
NNS |
denotes |
cells |
T11651 |
7380-7382 |
IN |
denotes |
in |
T11652 |
7383-7387 |
NN |
denotes |
vivo |
T11653 |
7388-7392 |
IN |
denotes |
with |
T11654 |
7393-7404 |
NN |
denotes |
possibility |
T11655 |
7405-7407 |
IN |
denotes |
of |
T11656 |
7408-7419 |
NN |
denotes |
interaction |
T11657 |
7420-7424 |
IN |
denotes |
with |
T11658 |
7425-7430 |
NN |
denotes |
naïve |
T11659 |
7431-7434 |
CC |
denotes |
and |
T11660 |
7435-7441 |
NN |
denotes |
memory |
T11661 |
7442-7443 |
NNP |
denotes |
B |
T11662 |
7444-7449 |
NNS |
denotes |
cells |
T11663 |
7450-7455 |
MD |
denotes |
might |
T11664 |
7456-7466 |
VB |
denotes |
contribute |
T11665 |
7467-7469 |
TO |
denotes |
to |
T11666 |
7470-7473 |
DT |
denotes |
the |
T11667 |
7474-7487 |
NN |
denotes |
understanding |
T11668 |
7488-7490 |
IN |
denotes |
of |
T11669 |
7491-7497 |
JJ |
denotes |
mature |
T11670 |
7498-7499 |
NNP |
denotes |
B |
T11671 |
7500-7504 |
NN |
denotes |
cell |
T11672 |
7505-7512 |
NN |
denotes |
biology |
T11673 |
7512-7513 |
. |
denotes |
. |
T11674 |
7514-7518 |
NNP |
denotes |
High |
T11675 |
7519-7524 |
NNP |
denotes |
BMP-6 |
T11676 |
7525-7529 |
NNP |
denotes |
mRNA |
T11677 |
7530-7540 |
NN |
denotes |
expression |
T11678 |
7541-7543 |
IN |
denotes |
in |
T11679 |
7544-7549 |
NNP |
denotes |
DLBCL |
T11680 |
7550-7553 |
VBZ |
denotes |
has |
T11681 |
7554-7558 |
VBN |
denotes |
been |
T11682 |
7559-7567 |
VBN |
denotes |
detected |
T11683 |
7568-7570 |
IN |
denotes |
by |
T11684 |
7571-7575 |
NN |
denotes |
gene |
T11685 |
7576-7586 |
NN |
denotes |
expression |
T11686 |
7587-7596 |
VBG |
denotes |
profiling |
T11687 |
7597-7598 |
NNP |
denotes |
[ |
T11688 |
7598-7600 |
CD |
denotes |
12 |
T11689 |
7600-7601 |
NNP |
denotes |
] |
T11690 |
7601-7602 |
. |
denotes |
. |
T11691 |
7603-7614 |
RB |
denotes |
Furthermore |
T11692 |
7614-7615 |
, |
denotes |
, |
T11693 |
7616-7626 |
NN |
denotes |
production |
T11694 |
7627-7629 |
IN |
denotes |
of |
T11695 |
7630-7635 |
NNP |
denotes |
BMP-6 |
T11696 |
7636-7647 |
NNS |
denotes |
transcripts |
T11697 |
7648-7650 |
IN |
denotes |
in |
T11698 |
7651-7657 |
JJ |
denotes |
normal |
T11699 |
7658-7667 |
VBN |
denotes |
activated |
T11700 |
7668-7669 |
NNP |
denotes |
B |
T11701 |
7670-7675 |
NNS |
denotes |
cells |
T11702 |
7676-7679 |
VBD |
denotes |
was |
T11703 |
7680-7688 |
VBN |
denotes |
detected |
T11704 |
7689-7691 |
IN |
denotes |
in |
T11705 |
7692-7695 |
DT |
denotes |
the |
T11706 |
7696-7700 |
JJ |
denotes |
same |
T11707 |
7701-7706 |
NN |
denotes |
study |
T11708 |
7706-7707 |
. |
denotes |
. |
T11709 |
7708-7710 |
IN |
denotes |
Of |
T11710 |
7711-7715 |
NN |
denotes |
note |
T11711 |
7715-7716 |
, |
denotes |
, |
T11712 |
7717-7719 |
DT |
denotes |
an |
T11713 |
7720-7729 |
NN |
denotes |
autocrine |
T11714 |
7730-7735 |
NN |
denotes |
BMP-6 |
T11715 |
7736-7740 |
NN |
denotes |
loop |
T11716 |
7741-7744 |
VBZ |
denotes |
has |
T11717 |
7745-7749 |
VBN |
denotes |
been |
T11718 |
7750-7758 |
VBN |
denotes |
reported |
T11719 |
7759-7761 |
IN |
denotes |
by |
T11720 |
7762-7768 |
NNS |
denotes |
others |
T11721 |
7769-7771 |
IN |
denotes |
in |
T11722 |
7772-7784 |
NNS |
denotes |
chondrocytes |
T11723 |
7785-7788 |
CC |
denotes |
and |
T11724 |
7789-7791 |
IN |
denotes |
in |
T11725 |
7792-7795 |
DT |
denotes |
the |
T11726 |
7796-7803 |
NN |
denotes |
ovarium |
T11727 |
7804-7805 |
NNP |
denotes |
[ |
T11728 |
7805-7813 |
CD |
denotes |
46,19,18 |
T11729 |
7813-7814 |
NNP |
denotes |
] |
T11730 |
7814-7815 |
. |
denotes |
. |
T11731 |
7816-7825 |
RB |
denotes |
Therefore |
T11732 |
7825-7826 |
, |
denotes |
, |
T11733 |
7827-7829 |
PRP |
denotes |
we |
T11734 |
7830-7836 |
VBD |
denotes |
wanted |
T11735 |
7837-7839 |
TO |
denotes |
to |
T11736 |
7840-7847 |
VB |
denotes |
explore |
T11737 |
7848-7851 |
DT |
denotes |
the |
T11738 |
7852-7863 |
NN |
denotes |
possibility |
T11739 |
7864-7867 |
IN |
denotes |
for |
T11740 |
7868-7870 |
DT |
denotes |
an |
T11741 |
7871-7880 |
NN |
denotes |
autocrine |
T11742 |
7881-7886 |
NN |
denotes |
BMP-6 |
T11743 |
7887-7891 |
NN |
denotes |
loop |
T11744 |
7892-7894 |
IN |
denotes |
in |
T11745 |
7895-7900 |
JJ |
denotes |
human |
T11746 |
7901-7902 |
NNP |
denotes |
B |
T11747 |
7903-7908 |
NNS |
denotes |
cells |
T11748 |
7908-7909 |
. |
denotes |
. |
T11749 |
7910-7912 |
PRP |
denotes |
We |
T11750 |
7913-7921 |
VBD |
denotes |
analysed |
T11751 |
7922-7925 |
DT |
denotes |
the |
T11752 |
7926-7936 |
NN |
denotes |
expression |
T11753 |
7937-7942 |
NNP |
denotes |
BMP-6 |
T11754 |
7943-7947 |
NNP |
denotes |
mRNA |
T11755 |
7948-7950 |
IN |
denotes |
in |
T11756 |
7951-7961 |
JJ |
denotes |
peripheral |
T11757 |
7962-7967 |
NN |
denotes |
blood |
T11758 |
7968-7969 |
NNP |
denotes |
B |
T11759 |
7970-7975 |
NNS |
denotes |
cells |
T11760 |
7976-7978 |
IN |
denotes |
by |
T11761 |
7979-7988 |
JJ |
denotes |
real-time |
T11762 |
7989-7992 |
NNP |
denotes |
PCR |
T11763 |
7992-7993 |
, |
denotes |
, |
T11764 |
7994-7997 |
CC |
denotes |
and |
T11765 |
7998-8004 |
NN |
denotes |
report |
T11766 |
8005-8009 |
RB |
denotes |
here |
T11767 |
8010-8013 |
DT |
denotes |
the |
T11768 |
8014-8026 |
NN |
denotes |
upregulation |
T11769 |
8027-8029 |
IN |
denotes |
of |
T11770 |
8030-8040 |
JJ |
denotes |
endogenous |
T11771 |
8041-8046 |
NN |
denotes |
BMP-6 |
T11772 |
8047-8058 |
NNS |
denotes |
transcripts |
T11773 |
8059-8064 |
IN |
denotes |
after |
T11774 |
8065-8076 |
NN |
denotes |
stimulation |
T11775 |
8077-8081 |
IN |
denotes |
with |
T11776 |
8082-8085 |
NNP |
denotes |
FCS |
T11777 |
8085-8086 |
, |
denotes |
, |
T11778 |
8087-8092 |
JJ |
denotes |
human |
T11779 |
8093-8101 |
NNP |
denotes |
AB-serum |
T11780 |
8102-8105 |
CC |
denotes |
and |
T11781 |
8105-8106 |
, |
denotes |
, |
T11782 |
8107-8111 |
RBS |
denotes |
most |
T11783 |
8112-8123 |
RB |
denotes |
importantly |
T11784 |
8123-8124 |
, |
denotes |
, |
T11785 |
8125-8133 |
JJ |
denotes |
anti-IgM |
T11786 |
8133-8134 |
. |
denotes |
. |
T11787 |
8135-8142 |
RB |
denotes |
However |
T11788 |
8142-8143 |
, |
denotes |
, |
T11789 |
8144-8147 |
PRP$ |
denotes |
our |
T11790 |
8148-8156 |
NNS |
denotes |
attempts |
T11791 |
8157-8159 |
TO |
denotes |
to |
T11792 |
8160-8165 |
VB |
denotes |
study |
T11793 |
8166-8171 |
NNP |
denotes |
BMP-6 |
T11794 |
8172-8179 |
NN |
denotes |
protein |
T11795 |
8180-8186 |
NNS |
denotes |
levels |
T11796 |
8187-8191 |
VBD |
denotes |
were |
T11797 |
8192-8204 |
JJ |
denotes |
unsuccessful |
T11798 |
8205-8208 |
JJ |
denotes |
due |
T11799 |
8209-8211 |
TO |
denotes |
to |
T11800 |
8212-8220 |
NNS |
denotes |
problems |
T11801 |
8221-8225 |
IN |
denotes |
with |
T11802 |
8226-8236 |
JJ |
denotes |
unspecific |
T11803 |
8237-8244 |
JJ |
denotes |
binding |
T11804 |
8245-8247 |
IN |
denotes |
of |
T11805 |
8248-8251 |
DT |
denotes |
the |
T11806 |
8252-8262 |
JJ |
denotes |
anti-BMP-6 |
T11807 |
8263-8273 |
NNS |
denotes |
antibodies |
T11808 |
8274-8280 |
VBN |
denotes |
tested |
T11809 |
8280-8281 |
, |
denotes |
, |
T11810 |
8282-8285 |
CC |
denotes |
and |
T11811 |
8286-8290 |
NN |
denotes |
lack |
T11812 |
8291-8293 |
IN |
denotes |
of |
T11813 |
8294-8302 |
JJ |
denotes |
specific |
T11814 |
8303-8311 |
VBG |
denotes |
staining |
T11815 |
8312-8314 |
IN |
denotes |
in |
T11816 |
8315-8322 |
NN |
denotes |
control |
T11817 |
8323-8328 |
NNS |
denotes |
cells |
T11818 |
8329-8334 |
VBN |
denotes |
known |
T11819 |
8335-8337 |
TO |
denotes |
to |
T11820 |
8338-8345 |
VB |
denotes |
express |
T11821 |
8346-8351 |
NNP |
denotes |
BMP-6 |
T11822 |
8352-8356 |
NNP |
denotes |
mRNA |
T11823 |
8356-8357 |
. |
denotes |
. |
T11824 |
8358-8360 |
IN |
denotes |
In |
T11825 |
8361-8369 |
NN |
denotes |
contrast |
T11826 |
8369-8370 |
, |
denotes |
, |
T11827 |
8371-8374 |
DT |
denotes |
the |
T11828 |
8375-8386 |
JJ |
denotes |
recombinant |
T11829 |
8387-8394 |
NN |
denotes |
protein |
T11830 |
8395-8398 |
VBD |
denotes |
was |
T11831 |
8399-8406 |
RB |
denotes |
readily |
T11832 |
8407-8415 |
VBN |
denotes |
detected |
T11833 |
8415-8416 |
. |
denotes |
. |
T11834 |
8417-8419 |
IN |
denotes |
In |
T11835 |
8420-8424 |
DT |
denotes |
that |
T11836 |
8425-8432 |
NN |
denotes |
respect |
T11837 |
8432-8433 |
, |
denotes |
, |
T11838 |
8434-8437 |
JJ |
denotes |
few |
T11839 |
8438-8451 |
NNS |
denotes |
investigators |
T11840 |
8452-8456 |
VBP |
denotes |
have |
T11841 |
8457-8465 |
VBN |
denotes |
detected |
T11842 |
8466-8471 |
NNP |
denotes |
BMP-6 |
T11843 |
8472-8479 |
NN |
denotes |
protein |
T11844 |
8480-8482 |
IN |
denotes |
in |
T11845 |
8483-8489 |
NNS |
denotes |
humans |
T11846 |
8489-8490 |
, |
denotes |
, |
T11847 |
8491-8501 |
RB |
denotes |
especially |
T11848 |
8502-8504 |
IN |
denotes |
in |
T11849 |
8505-8519 |
JJ |
denotes |
non-pathogenic |
T11850 |
8520-8526 |
NN |
denotes |
tissue |
T11851 |
8526-8527 |
. |
denotes |
. |
T11852 |
8528-8531 |
DT |
denotes |
The |
T11853 |
8532-8543 |
NN |
denotes |
possibility |
T11854 |
8544-8546 |
IN |
denotes |
of |
T11855 |
8547-8552 |
NN |
denotes |
BMP-6 |
T11856 |
8553-8563 |
NN |
denotes |
production |
T11857 |
8564-8566 |
IN |
denotes |
in |
T11858 |
8567-8572 |
JJ |
denotes |
human |
T11859 |
8573-8580 |
NNPS |
denotes |
B-cells |
T11860 |
8581-8583 |
VBZ |
denotes |
is |
T11861 |
8584-8586 |
IN |
denotes |
in |
T11862 |
8587-8591 |
NN |
denotes |
line |
T11863 |
8592-8596 |
IN |
denotes |
with |
T11864 |
8597-8598 |
DT |
denotes |
a |
T11865 |
8599-8605 |
JJ |
denotes |
recent |
T11866 |
8606-8610 |
NN |
denotes |
work |
T11867 |
8611-8615 |
WDT |
denotes |
that |
T11868 |
8616-8624 |
VBD |
denotes |
reported |
T11869 |
8625-8628 |
DT |
denotes |
the |
T11870 |
8629-8639 |
NN |
denotes |
production |
T11871 |
8640-8642 |
IN |
denotes |
of |
T11872 |
8643-8648 |
NN |
denotes |
BMP-6 |
T11873 |
8649-8651 |
IN |
denotes |
in |
T11874 |
8652-8657 |
NN |
denotes |
mouse |
T11875 |
8658-8659 |
NNP |
denotes |
B |
T11876 |
8660-8665 |
NNS |
denotes |
cells |
T11877 |
8665-8666 |
, |
denotes |
, |
T11878 |
8667-8679 |
VBG |
denotes |
infiltrating |
T11879 |
8680-8683 |
DT |
denotes |
the |
T11880 |
8684-8688 |
NN |
denotes |
bone |
T11881 |
8689-8695 |
NN |
denotes |
marrow |
T11882 |
8696-8698 |
IN |
denotes |
of |
T11883 |
8699-8703 |
NNS |
denotes |
mice |
T11884 |
8704-8708 |
IN |
denotes |
with |
T11885 |
8709-8721 |
JJ |
denotes |
inflammatory |
T11886 |
8722-8731 |
NNS |
denotes |
arthritis |
T11887 |
8732-8733 |
NNP |
denotes |
[ |
T11888 |
8733-8735 |
CD |
denotes |
43 |
T11889 |
8735-8736 |
NNP |
denotes |
] |
T11890 |
8736-8737 |
. |
denotes |
. |
T11891 |
8738-8740 |
IN |
denotes |
In |
T11892 |
8741-8745 |
DT |
denotes |
this |
T11893 |
8746-8751 |
NN |
denotes |
study |
T11894 |
8751-8752 |
, |
denotes |
, |
T11895 |
8753-8754 |
DT |
denotes |
a |
T11896 |
8755-8759 |
NN |
denotes |
role |
T11897 |
8760-8763 |
IN |
denotes |
for |
T11898 |
8764-8768 |
NNS |
denotes |
BMPs |
T11899 |
8769-8771 |
IN |
denotes |
in |
T11900 |
8772-8775 |
DT |
denotes |
the |
T11901 |
8776-8789 |
JJ |
denotes |
inflammatoric |
T11902 |
8790-8797 |
NN |
denotes |
process |
T11903 |
8798-8800 |
IN |
denotes |
of |
T11904 |
8801-8810 |
NN |
denotes |
arthritis |
T11905 |
8811-8814 |
VBD |
denotes |
was |
T11906 |
8815-8824 |
VBN |
denotes |
suggested |
T11907 |
8824-8825 |
. |
denotes |
. |
T11908 |
8826-8829 |
DT |
denotes |
The |
T11909 |
8830-8842 |
NN |
denotes |
upregulation |
T11910 |
8843-8845 |
IN |
denotes |
of |
T11911 |
8846-8849 |
DT |
denotes |
the |
T11912 |
8850-8867 |
NNS |
denotes |
BMP-6-transcripts |
T11913 |
8868-8873 |
IN |
denotes |
after |
T11914 |
8874-8890 |
NNP |
denotes |
IgM-crosslinking |
T11915 |
8891-8893 |
VBZ |
denotes |
is |
T11916 |
8894-8896 |
IN |
denotes |
of |
T11917 |
8897-8913 |
JJ |
denotes |
pathophysiologic |
T11918 |
8914-8922 |
NN |
denotes |
interest |
T11919 |
8923-8924 |
NNP |
denotes |
[ |
T11920 |
8924-8926 |
CD |
denotes |
12 |
T11921 |
8926-8927 |
NNP |
denotes |
] |
T11922 |
8927-8928 |
. |
denotes |
. |
T11923 |
8929-8930 |
DT |
denotes |
A |
T11924 |
8931-8935 |
NN |
denotes |
loss |
T11925 |
8936-8938 |
IN |
denotes |
of |
T11926 |
8939-8959 |
NN |
denotes |
TGF-β-responsiveness |
T11927 |
8960-8963 |
VBZ |
denotes |
has |
T11928 |
8964-8968 |
VBN |
denotes |
been |
T11929 |
8969-8978 |
VBN |
denotes |
suggested |
T11930 |
8979-8981 |
TO |
denotes |
to |
T11931 |
8982-8984 |
VB |
denotes |
be |
T11932 |
8985-8986 |
DT |
denotes |
a |
T11933 |
8987-8995 |
JJ |
denotes |
critical |
T11934 |
8996-9008 |
NN |
denotes |
contribution |
T11935 |
9009-9011 |
TO |
denotes |
to |
T11936 |
9012-9021 |
JJ |
denotes |
malignant |
T11937 |
9022-9036 |
NN |
denotes |
transformation |
T11938 |
9037-9038 |
NNP |
denotes |
[ |
T11939 |
9038-9043 |
CD |
denotes |
47,48 |
T11940 |
9043-9044 |
NNP |
denotes |
] |
T11941 |
9045-9048 |
CC |
denotes |
and |
T11942 |
9049-9056 |
JJ |
denotes |
similar |
T11943 |
9057-9066 |
JJ |
denotes |
oncogenic |
T11944 |
9067-9077 |
NNS |
denotes |
mechanisms |
T11945 |
9078-9082 |
VBP |
denotes |
have |
T11946 |
9083-9087 |
VBN |
denotes |
been |
T11947 |
9088-9098 |
VBN |
denotes |
postulated |
T11948 |
9099-9102 |
IN |
denotes |
for |
T11949 |
9103-9107 |
NNS |
denotes |
BMPs |
T11950 |
9107-9108 |
. |
denotes |
. |
T11951 |
9109-9114 |
NNS |
denotes |
Lines |
T11952 |
9115-9117 |
IN |
denotes |
of |
T11953 |
9118-9126 |
NN |
denotes |
evidence |
T11954 |
9127-9134 |
VBP |
denotes |
suggest |
T11955 |
9135-9136 |
NNP |
denotes |
[ |
T11956 |
9136-9138 |
CD |
denotes |
49 |
T11957 |
9138-9139 |
NN |
denotes |
] |
T11958 |
9140-9144 |
WDT |
denotes |
that |
T11959 |
9145-9147 |
IN |
denotes |
at |
T11960 |
9148-9153 |
JJ |
denotes |
early |
T11961 |
9154-9160 |
NNS |
denotes |
stages |
T11962 |
9161-9163 |
IN |
denotes |
of |
T11963 |
9164-9178 |
NN |
denotes |
carcinogenesis |
T11964 |
9178-9179 |
, |
denotes |
, |
T11965 |
9180-9185 |
NNP |
denotes |
BMP-6 |
T11966 |
9186-9188 |
VBZ |
denotes |
is |
T11967 |
9189-9192 |
RB |
denotes |
not |
T11968 |
9193-9194 |
DT |
denotes |
a |
T11969 |
9195-9201 |
NN |
denotes |
tumour |
T11970 |
9202-9210 |
NN |
denotes |
promoter |
T11971 |
9210-9211 |
, |
denotes |
, |
T11972 |
9212-9215 |
CC |
denotes |
but |
T11973 |
9216-9226 |
VBZ |
denotes |
suppresses |
T11974 |
9227-9233 |
JJ |
denotes |
benign |
T11975 |
9234-9237 |
CC |
denotes |
and |
T11976 |
9238-9247 |
JJ |
denotes |
malignant |
T11977 |
9248-9254 |
NN |
denotes |
tumour |
T11978 |
9255-9264 |
NN |
denotes |
outgrowth |
T11979 |
9264-9265 |
. |
denotes |
. |
T11980 |
9266-9271 |
DT |
denotes |
These |
T11981 |
9272-9280 |
NNS |
denotes |
findings |
T11982 |
9281-9284 |
VBP |
denotes |
are |
T11983 |
9285-9287 |
IN |
denotes |
in |
T11984 |
9288-9292 |
JJ |
denotes |
good |
T11985 |
9293-9302 |
NN |
denotes |
agreement |
T11986 |
9303-9307 |
IN |
denotes |
with |
T11987 |
9308-9316 |
JJ |
denotes |
previous |
T11988 |
9317-9325 |
NNS |
denotes |
findings |
T11989 |
9326-9329 |
IN |
denotes |
for |
T11990 |
9330-9335 |
JJ |
denotes |
other |
T11991 |
9336-9341 |
NNP |
denotes |
TGF-β |
T11992 |
9342-9348 |
NN |
denotes |
family |
T11993 |
9349-9356 |
NNS |
denotes |
members |
T11994 |
9356-9357 |
, |
denotes |
, |
T11995 |
9358-9367 |
VBG |
denotes |
including |
T11996 |
9368-9374 |
NNP |
denotes |
TGF-β1 |
T11997 |
9375-9378 |
CC |
denotes |
and |
T11998 |
9379-9384 |
NNP |
denotes |
BMP-4 |
T11999 |
9385-9386 |
NNP |
denotes |
[ |
T12000 |
9386-9388 |
CD |
denotes |
50 |
T12001 |
9388-9389 |
NNP |
denotes |
] |
T12002 |
9389-9390 |
, |
denotes |
, |
T12003 |
9391-9401 |
VBG |
denotes |
indicating |
T12004 |
9402-9406 |
IN |
denotes |
that |
T12005 |
9407-9415 |
JJ |
denotes |
cellular |
T12006 |
9416-9423 |
NN |
denotes |
context |
T12007 |
9424-9426 |
IN |
denotes |
of |
T12008 |
9427-9430 |
DT |
denotes |
the |
T12009 |
9431-9434 |
NN |
denotes |
BMP |
T12010 |
9435-9441 |
NN |
denotes |
target |
T12011 |
9442-9446 |
NN |
denotes |
cell |
T12012 |
9447-9452 |
MD |
denotes |
might |
T12013 |
9453-9459 |
VB |
denotes |
define |
T12014 |
9460-9463 |
DT |
denotes |
the |
T12015 |
9464-9471 |
JJ |
denotes |
various |
T12016 |
9472-9480 |
JJ |
denotes |
observed |
T12017 |
9481-9488 |
NNS |
denotes |
effects |
T12018 |
9488-9489 |
. |
denotes |
. |
T12019 |
9490-9492 |
IN |
denotes |
In |
T12020 |
9493-9501 |
NN |
denotes |
contrast |
T12021 |
9502-9504 |
TO |
denotes |
to |
T12022 |
9505-9508 |
DT |
denotes |
the |
T12023 |
9509-9521 |
NN |
denotes |
upregulation |
T12024 |
9522-9524 |
IN |
denotes |
of |
T12025 |
9525-9530 |
NNP |
denotes |
BMP-6 |
T12026 |
9531-9541 |
NN |
denotes |
transcript |
T12027 |
9542-9544 |
IN |
denotes |
in |
T12028 |
9545-9546 |
NNP |
denotes |
B |
T12029 |
9547-9552 |
NNS |
denotes |
cells |
T12030 |
9552-9553 |
, |
denotes |
, |
T12031 |
9554-9556 |
PRP |
denotes |
we |
T12032 |
9557-9561 |
VBD |
denotes |
were |
T12033 |
9562-9565 |
RB |
denotes |
not |
T12034 |
9566-9570 |
JJ |
denotes |
able |
T12035 |
9571-9573 |
TO |
denotes |
to |
T12036 |
9574-9580 |
VB |
denotes |
detect |
T12037 |
9581-9586 |
NNP |
denotes |
BMP-6 |
T12038 |
9587-9598 |
NNS |
denotes |
transcripts |
T12039 |
9599-9601 |
IN |
denotes |
in |
T12040 |
9602-9607 |
JJ |
denotes |
human |
T12041 |
9608-9618 |
JJ |
denotes |
peripheral |
T12042 |
9619-9624 |
NN |
denotes |
blood |
T12043 |
9625-9628 |
NNP |
denotes |
CD4 |
T12044 |
9628-9629 |
CD |
denotes |
+ |
T12045 |
9630-9632 |
CC |
denotes |
or |
T12046 |
9633-9636 |
CD |
denotes |
CD8 |
T12047 |
9636-9637 |
CD |
denotes |
+ |
T12048 |
9638-9639 |
NNP |
denotes |
T |
T12049 |
9640-9645 |
NNS |
denotes |
cells |
T12050 |
9646-9647 |
-LRB- |
denotes |
( |
T12051 |
9647-9654 |
VBG |
denotes |
resting |
T12052 |
9655-9657 |
CC |
denotes |
or |
T12053 |
9658-9668 |
VBN |
denotes |
stimulated |
T12054 |
9669-9673 |
IN |
denotes |
with |
T12055 |
9674-9682 |
JJ |
denotes |
anti-CD3 |
T12056 |
9683-9686 |
CC |
denotes |
and |
T12057 |
9687-9696 |
JJ |
denotes |
anti-CD28 |
T12058 |
9696-9697 |
: |
denotes |
; |
T12059 |
9698-9702 |
NNS |
denotes |
data |
T12060 |
9703-9706 |
RB |
denotes |
not |
T12061 |
9707-9712 |
VBN |
denotes |
shown |
T12062 |
9712-9713 |
-RRB- |
denotes |
) |
T12063 |
9713-9714 |
, |
denotes |
, |
T12064 |
9715-9725 |
JJ |
denotes |
consistent |
T12065 |
9726-9730 |
IN |
denotes |
with |
T12066 |
9731-9734 |
DT |
denotes |
the |
T12067 |
9735-9743 |
NNS |
denotes |
findings |
T12068 |
9744-9746 |
IN |
denotes |
in |
T12069 |
9747-9748 |
NNP |
denotes |
T |
T12070 |
9749-9753 |
NN |
denotes |
cell |
T12071 |
9754-9759 |
NNS |
denotes |
lines |
T12072 |
9760-9761 |
NNP |
denotes |
[ |
T12073 |
9761-9763 |
CD |
denotes |
20 |
T12074 |
9763-9764 |
NNP |
denotes |
] |
T12075 |
9765-9768 |
CC |
denotes |
and |
T12076 |
9769-9770 |
NNP |
denotes |
T |
T12077 |
9771-9776 |
NNS |
denotes |
cells |
T12078 |
9777-9779 |
IN |
denotes |
in |
T12079 |
9780-9784 |
NNS |
denotes |
mice |
T12080 |
9785-9786 |
NNP |
denotes |
[ |
T12081 |
9786-9788 |
CD |
denotes |
43 |
T12082 |
9788-9789 |
NNP |
denotes |
] |
T12083 |
9789-9790 |
. |
denotes |
. |
T12084 |
9791-9796 |
JJ |
denotes |
Other |
T12085 |
9797-9806 |
JJ |
denotes |
potential |
T12086 |
9807-9812 |
NN |
denotes |
BMP-6 |
T12087 |
9813-9820 |
NNS |
denotes |
sources |
T12088 |
9821-9824 |
IN |
denotes |
for |
T12089 |
9825-9831 |
JJ |
denotes |
mature |
T12090 |
9832-9833 |
NNP |
denotes |
B |
T12091 |
9834-9839 |
NNS |
denotes |
cells |
T12092 |
9840-9842 |
IN |
denotes |
in |
T12093 |
9843-9847 |
NN |
denotes |
vivo |
T12094 |
9848-9853 |
MD |
denotes |
might |
T12095 |
9854-9856 |
VB |
denotes |
be |
T12096 |
9857-9862 |
JJ |
denotes |
other |
T12097 |
9863-9868 |
NNS |
denotes |
cells |
T12098 |
9869-9871 |
IN |
denotes |
of |
T12099 |
9872-9875 |
DT |
denotes |
the |
T12100 |
9876-9882 |
JJ |
denotes |
immune |
T12101 |
9883-9889 |
NN |
denotes |
system |
T12102 |
9890-9892 |
CC |
denotes |
or |
T12103 |
9893-9899 |
NN |
denotes |
tissue |
T12104 |
9900-9904 |
IN |
denotes |
with |
T12105 |
9905-9912 |
NN |
denotes |
contact |
T12106 |
9913-9915 |
TO |
denotes |
to |
T12107 |
9916-9919 |
DT |
denotes |
the |
T12108 |
9920-9933 |
JJ |
denotes |
hematopoietic |
T12109 |
9934-9940 |
NN |
denotes |
system |
T12110 |
9940-9941 |
. |
denotes |
. |
T12111 |
9942-9945 |
CD |
denotes |
One |
T12112 |
9946-9950 |
RB |
denotes |
well |
T12113 |
9951-9961 |
VBN |
denotes |
recognized |
T12114 |
9962-9968 |
NN |
denotes |
source |
T12115 |
9969-9972 |
IN |
denotes |
for |
T12116 |
9973-9978 |
NN |
denotes |
BMP-6 |
T12117 |
9979-9989 |
NN |
denotes |
production |
T12118 |
9990-9992 |
VBZ |
denotes |
is |
T12119 |
9993-9996 |
DT |
denotes |
the |
T12120 |
9997-10002 |
JJ |
denotes |
human |
T12121 |
10003-10007 |
NN |
denotes |
bone |
T12122 |
10008-10011 |
CC |
denotes |
and |
T12123 |
10012-10016 |
NN |
denotes |
bone |
T12124 |
10017-10023 |
NN |
denotes |
marrow |
T12125 |
10024-10030 |
NN |
denotes |
stroma |
T12126 |
10031-10032 |
NNP |
denotes |
[ |
T12127 |
10032-10036 |
CD |
denotes |
51,8 |
T12128 |
10036-10037 |
NNP |
denotes |
] |
T12129 |
10037-10038 |
. |
denotes |
. |
T12130 |
10039-10050 |
RB |
denotes |
Furthermore |
T12131 |
10050-10051 |
, |
denotes |
, |
T12132 |
10052-10054 |
PRP |
denotes |
it |
T12133 |
10055-10057 |
VBZ |
denotes |
is |
T12134 |
10058-10068 |
JJ |
denotes |
noteworthy |
T12135 |
10069-10073 |
IN |
denotes |
that |
T12136 |
10074-10079 |
JJ |
denotes |
human |
T12137 |
10080-10089 |
JJ |
denotes |
umbilical |
T12138 |
10090-10094 |
NN |
denotes |
vein |
T12139 |
10095-10106 |
JJ |
denotes |
endothelial |
T12140 |
10107-10112 |
NNS |
denotes |
cells |
T12141 |
10113-10114 |
-LRB- |
denotes |
( |
T12142 |
10114-10119 |
NNP |
denotes |
HUVEC |
T12143 |
10119-10120 |
-RRB- |
denotes |
) |
T12144 |
10121-10127 |
RB |
denotes |
highly |
T12145 |
10128-10135 |
JJ |
denotes |
express |
T12146 |
10136-10141 |
NNP |
denotes |
BMP-6 |
T12147 |
10142-10146 |
NNP |
denotes |
mRNA |
T12148 |
10147-10148 |
NNP |
denotes |
[ |
T12149 |
10148-10150 |
CD |
denotes |
52 |
T12150 |
10150-10151 |
NNP |
denotes |
] |
T12151 |
10151-10152 |
, |
denotes |
, |
T12152 |
10153-10156 |
CC |
denotes |
and |
T12153 |
10157-10165 |
JJ |
denotes |
vascular |
T12154 |
10166-10177 |
NN |
denotes |
endothelium |
T12155 |
10178-10181 |
VBZ |
denotes |
has |
T12156 |
10182-10186 |
VBN |
denotes |
been |
T12157 |
10187-10195 |
VBN |
denotes |
reported |
T12158 |
10196-10198 |
TO |
denotes |
to |
T12159 |
10199-10206 |
VB |
denotes |
produce |
T12160 |
10207-10212 |
NNP |
denotes |
BMP-6 |
T12161 |
10213-10214 |
NNP |
denotes |
[ |
T12162 |
10214-10216 |
CD |
denotes |
53 |
T12163 |
10216-10217 |
NNP |
denotes |
] |
T12164 |
10217-10218 |
. |
denotes |
. |
T12165 |
10219-10224 |
DT |
denotes |
These |
T12166 |
10225-10232 |
NNS |
denotes |
studies |
T12167 |
10233-10238 |
MD |
denotes |
might |
T12168 |
10239-10244 |
VB |
denotes |
imply |
T12169 |
10245-10246 |
DT |
denotes |
a |
T12170 |
10247-10251 |
NN |
denotes |
role |
T12171 |
10252-10255 |
IN |
denotes |
for |
T12172 |
10256-10261 |
NNP |
denotes |
BMP-6 |
T12173 |
10262-10264 |
IN |
denotes |
in |
T12174 |
10265-10281 |
JJ |
denotes |
transendothelial |
T12175 |
10282-10291 |
NN |
denotes |
migration |
T12176 |
10292-10294 |
IN |
denotes |
of |
T12177 |
10295-10296 |
NNP |
denotes |
B |
T12178 |
10297-10302 |
NNS |
denotes |
cells |
T12179 |
10302-10303 |
. |
denotes |
. |
T12180 |
10304-10309 |
CD |
denotes |
BMP-6 |
T12181 |
10310-10314 |
NNP |
denotes |
mRNA |
T12182 |
10315-10318 |
VBZ |
denotes |
has |
T12183 |
10319-10323 |
VBN |
denotes |
been |
T12184 |
10324-10336 |
VBN |
denotes |
demonstrated |
T12185 |
10337-10339 |
IN |
denotes |
in |
T12186 |
10340-10346 |
NN |
denotes |
murine |
T12187 |
10347-10357 |
NN |
denotes |
macrophage |
T12188 |
10358-10362 |
NN |
denotes |
cell |
T12189 |
10363-10368 |
NNS |
denotes |
lines |
T12190 |
10368-10369 |
, |
denotes |
, |
T12191 |
10370-10373 |
CC |
denotes |
but |
T12192 |
10374-10377 |
RB |
denotes |
not |
T12193 |
10378-10380 |
IN |
denotes |
in |
T12194 |
10381-10387 |
NNS |
denotes |
humans |
T12195 |
10388-10389 |
NNP |
denotes |
[ |
T12196 |
10389-10391 |
CD |
denotes |
54 |
T12197 |
10391-10392 |
NNP |
denotes |
] |
T12198 |
10392-10393 |
. |
denotes |
. |
T12199 |
10394-10396 |
IN |
denotes |
In |
T12200 |
10397-10407 |
NN |
denotes |
accordance |
T12201 |
10408-10412 |
IN |
denotes |
with |
T12202 |
10413-10418 |
DT |
denotes |
these |
T12203 |
10419-10427 |
NNS |
denotes |
findings |
T12204 |
10427-10428 |
, |
denotes |
, |
T12205 |
10429-10434 |
JJ |
denotes |
other |
T12206 |
10435-10440 |
JJ |
denotes |
human |
T12207 |
10441-10445 |
NN |
denotes |
cell |
T12208 |
10446-10451 |
NNS |
denotes |
lines |
T12209 |
10452-10454 |
IN |
denotes |
of |
T12210 |
10455-10465 |
NN |
denotes |
neutrophil |
T12211 |
10466-10469 |
CC |
denotes |
and |
T12212 |
10470-10479 |
JJ |
denotes |
monocytic |
T12213 |
10480-10486 |
NN |
denotes |
origin |
T12214 |
10487-10491 |
VBP |
denotes |
have |
T12215 |
10492-10496 |
VBN |
denotes |
been |
T12216 |
10497-10506 |
VBN |
denotes |
described |
T12217 |
10507-10509 |
TO |
denotes |
to |
T12218 |
10510-10512 |
VB |
denotes |
be |
T12219 |
10513-10521 |
JJ |
denotes |
negative |
T12220 |
10522-10525 |
IN |
denotes |
for |
T12221 |
10526-10529 |
DT |
denotes |
the |
T12222 |
10530-10535 |
NNP |
denotes |
BMP-6 |
T12223 |
10536-10546 |
NN |
denotes |
transcript |
T12224 |
10547-10548 |
NNP |
denotes |
[ |
T12225 |
10548-10550 |
CD |
denotes |
20 |
T12226 |
10550-10551 |
NNP |
denotes |
] |
T12227 |
10551-10552 |
. |
denotes |
. |
T12228 |
10553-10555 |
TO |
denotes |
To |
T12229 |
10556-10559 |
PRP$ |
denotes |
our |
T12230 |
10560-10569 |
NN |
denotes |
knowledge |
T12231 |
10569-10570 |
, |
denotes |
, |
T12232 |
10571-10576 |
EX |
denotes |
there |
T12233 |
10577-10579 |
VBZ |
denotes |
is |
T12234 |
10580-10589 |
RB |
denotes |
currently |
T12235 |
10590-10592 |
DT |
denotes |
no |
T12236 |
10593-10599 |
NN |
denotes |
report |
T12237 |
10600-10605 |
IN |
denotes |
about |
T12238 |
10606-10611 |
NN |
denotes |
BMP-6 |
T12239 |
10612-10622 |
NN |
denotes |
production |
T12240 |
10623-10625 |
IN |
denotes |
of |
T12241 |
10626-10631 |
JJ |
denotes |
human |
T12242 |
10632-10641 |
JJ |
denotes |
dendritic |
T12243 |
10642-10647 |
NNS |
denotes |
cells |
T12244 |
10647-10648 |
. |
denotes |
. |
R7899 |
T10336 |
T10338 |
amod |
hematopoietic,cells |
R7900 |
T10324 |
T10325 |
amod |
Recent,studies |
R7901 |
T10325 |
T10327 |
nsubj |
studies,demonstrated |
R7902 |
T10326 |
T10327 |
aux |
have,demonstrated |
R7903 |
T10327 |
T10366 |
ccomp |
demonstrated,reported |
R7904 |
T10328 |
T10330 |
det |
an,role |
R7905 |
T10329 |
T10330 |
amod |
important,role |
R7906 |
T10330 |
T10327 |
dobj |
role,demonstrated |
R7907 |
T10331 |
T10330 |
prep |
for,role |
R7908 |
T10332 |
T10334 |
compound |
BMP,members |
R7909 |
T10333 |
T10334 |
compound |
superfamily,members |
R7910 |
T10334 |
T10331 |
pobj |
members,for |
R7911 |
T10335 |
T10330 |
prep |
in,role |
R7912 |
T10337 |
T10338 |
compound |
stem,cells |
R7913 |
T10338 |
T10335 |
pobj |
cells,in |
R7914 |
T10383 |
T10384 |
compound |
B,cells |
R7915 |
T10339 |
T10330 |
punct |
",",role |
R7916 |
T10384 |
T10378 |
pobj |
cells,in |
R7917 |
T10385 |
T10371 |
punct |
.,demonstrated |
R7918 |
T10386 |
T10389 |
advmod |
Additionally,induced |
R7919 |
T10340 |
T10341 |
amod |
early,thymocytes |
R7920 |
T10387 |
T10389 |
punct |
",",induced |
R7921 |
T10388 |
T10389 |
nsubj |
BMP-6,induced |
R7922 |
T10389 |
T10389 |
ROOT |
induced,induced |
R7923 |
T10341 |
T10344 |
nmod |
thymocytes,] |
R7924 |
T10390 |
T10391 |
compound |
cell,death |
R7925 |
T10391 |
T10389 |
dobj |
death,induced |
R7926 |
T10392 |
T10389 |
prep |
in,induced |
R7927 |
T10342 |
T10344 |
nmod |
[,] |
R7928 |
T10393 |
T10396 |
compound |
CD27,B |
R7929 |
T10394 |
T10396 |
compound |
+,B |
R7930 |
T10395 |
T10396 |
compound |
memory,B |
R7931 |
T10343 |
T10344 |
nummod |
"6,7",] |
R7932 |
T10396 |
T10397 |
compound |
B,cells |
R7933 |
T10397 |
T10392 |
pobj |
cells,in |
R7934 |
T10398 |
T10400 |
advmod |
as,as |
R7935 |
T10344 |
T10347 |
nmod |
],malignancies |
R7936 |
T10399 |
T10400 |
advmod |
well,as |
R7937 |
T10400 |
T10392 |
cc |
as,in |
R7938 |
T10401 |
T10392 |
conj |
in,in |
R7939 |
T10345 |
T10344 |
cc |
and,] |
R7940 |
T10402 |
T10406 |
det |
a,line |
R7941 |
T10403 |
T10406 |
compound |
Burkitt,line |
R7942 |
T10404 |
T10405 |
compound |
lymphoma,cell |
R7943 |
T10346 |
T10344 |
conj |
B-cell,] |
R7944 |
T10405 |
T10406 |
compound |
cell,line |
R7945 |
T10406 |
T10401 |
pobj |
line,in |
R7946 |
T10347 |
T10366 |
nsubj |
malignancies,reported |
R7947 |
T10407 |
T10406 |
punct |
(,line |
R7948 |
T10408 |
T10406 |
appos |
Ramos,line |
R7949 |
T10409 |
T10406 |
punct |
),line |
R7950 |
T10348 |
T10350 |
compound |
[,] |
R7951 |
T10410 |
T10389 |
punct |
.,induced |
R7952 |
T10411 |
T10414 |
advmod |
Importantly,induced |
R7953 |
T10349 |
T10350 |
compound |
"8,11,12",] |
R7954 |
T10412 |
T10414 |
punct |
",",induced |
R7955 |
T10413 |
T10414 |
nsubj |
BMP-6,induced |
R7956 |
T10414 |
T10414 |
ROOT |
induced,induced |
R7957 |
T10415 |
T10419 |
det |
a,increase |
R7958 |
T10416 |
T10419 |
amod |
rapid,increase |
R7959 |
T10417 |
T10416 |
cc |
and,rapid |
R7960 |
T10418 |
T10416 |
conj |
marked,rapid |
R7961 |
T10350 |
T10347 |
dobj |
],malignancies |
R7962 |
T10419 |
T10414 |
dobj |
increase,induced |
R7963 |
T10420 |
T10419 |
prep |
in,increase |
R7964 |
T10421 |
T10424 |
quantmod |
Smad-1,phosphorylation |
R7965 |
T10351 |
T10347 |
punct |
",",malignancies |
R7966 |
T10422 |
T10423 |
compound |
/,5/8 |
R7967 |
T10423 |
T10424 |
nummod |
5/8,phosphorylation |
R7968 |
T10352 |
T10347 |
cc |
but,malignancies |
R7969 |
T10353 |
T10354 |
det |
a,role |
R7970 |
T10424 |
T10420 |
pobj |
phosphorylation,in |
R7971 |
T10354 |
T10347 |
conj |
role,malignancies |
R7972 |
T10425 |
T10414 |
punct |
.,induced |
R7973 |
T10426 |
T10430 |
advmod |
Furthermore,induced |
R7974 |
T10427 |
T10430 |
punct |
",",induced |
R7975 |
T10355 |
T10354 |
prep |
for,role |
R7976 |
T10428 |
T10429 |
det |
the,BMP-6 |
R7977 |
T10429 |
T10430 |
nsubj |
BMP-6,induced |
R7978 |
T10356 |
T10355 |
pobj |
BMPs,for |
R7979 |
T10430 |
T10430 |
ROOT |
induced,induced |
R7980 |
T10431 |
T10432 |
compound |
Smad,phosphorylation |
R7981 |
T10432 |
T10434 |
nsubjpass |
phosphorylation,followed |
R7982 |
T10357 |
T10356 |
prep |
in,BMPs |
R7983 |
T10433 |
T10434 |
auxpass |
was,followed |
R7984 |
T10434 |
T10430 |
advcl |
followed,induced |
R7985 |
T10435 |
T10434 |
agent |
by,followed |
R7986 |
T10358 |
T10361 |
amod |
normal,cells |
R7987 |
T10436 |
T10438 |
det |
a,upregulation |
R7988 |
T10437 |
T10438 |
amod |
selective,upregulation |
R7989 |
T10438 |
T10435 |
pobj |
upregulation,by |
R7990 |
T10359 |
T10361 |
amod |
human,cells |
R7991 |
T10439 |
T10438 |
prep |
of,upregulation |
R7992 |
T10440 |
T10441 |
compound |
Id1,mRNA |
R7993 |
T10441 |
T10439 |
pobj |
mRNA,of |
R7994 |
T10442 |
T10441 |
cc |
and,mRNA |
R7995 |
T10360 |
T10361 |
compound |
B,cells |
R7996 |
T10361 |
T10357 |
pobj |
cells,in |
R7997 |
T10443 |
T10445 |
amod |
subsequent,protein |
R7998 |
T10444 |
T10445 |
amod |
Id1,protein |
R7999 |
T10362 |
T10366 |
aux |
has,reported |
R8000 |
T10445 |
T10438 |
conj |
protein,upregulation |
R8001 |
T10446 |
T10434 |
punct |
.,followed |
R8002 |
T10363 |
T10366 |
advmod |
previously,reported |
R8003 |
T10447 |
T10463 |
prep |
In,was |
R8004 |
T10448 |
T10450 |
det |
the,study |
R8005 |
T10449 |
T10450 |
amod |
present,study |
R8006 |
T10364 |
T10366 |
neg |
not,reported |
R8007 |
T10450 |
T10447 |
pobj |
study,In |
R8008 |
T10451 |
T10463 |
punct |
",",was |
R8009 |
T10452 |
T10455 |
det |
the,effect |
R8010 |
T10453 |
T10455 |
amod |
demonstrated,effect |
R8011 |
T10454 |
T10455 |
amod |
antiproliferative,effect |
R8012 |
T10455 |
T10463 |
nsubj |
effect,was |
R8013 |
T10365 |
T10366 |
auxpass |
been,reported |
R8014 |
T10456 |
T10455 |
prep |
of,effect |
R8015 |
T10457 |
T10456 |
pobj |
BMP-6,of |
R8016 |
T10458 |
T10457 |
prep |
in,BMP-6 |
R8017 |
T10366 |
T10366 |
ROOT |
reported,reported |
R8018 |
T10459 |
T10462 |
amod |
anti-IgM,cells |
R8019 |
T10460 |
T10462 |
amod |
treated,cells |
R8020 |
T10367 |
T10366 |
punct |
.,reported |
R8021 |
T10461 |
T10462 |
compound |
B,cells |
R8022 |
T10462 |
T10458 |
pobj |
cells,in |
R8023 |
T10463 |
T10463 |
ROOT |
was,was |
R8024 |
T10464 |
T10463 |
acomp |
significant,was |
R8025 |
T10368 |
T10370 |
det |
The,study |
R8026 |
T10465 |
T10464 |
cc |
and,significant |
R8027 |
T10466 |
T10464 |
conj |
dose-dependent,significant |
R8028 |
T10467 |
T10463 |
punct |
.,was |
R8029 |
T10468 |
T10478 |
advmod |
Importantly,neutralized |
R8030 |
T10369 |
T10370 |
amod |
present,study |
R8031 |
T10469 |
T10478 |
punct |
",",neutralized |
R8032 |
T10470 |
T10472 |
det |
the,effect |
R8033 |
T10471 |
T10472 |
amod |
anti-proliferative,effect |
R8034 |
T10370 |
T10371 |
nsubj |
study,demonstrated |
R8035 |
T10472 |
T10478 |
nsubjpass |
effect,neutralized |
R8036 |
T10473 |
T10472 |
prep |
of,effect |
R8037 |
T10371 |
T10371 |
ROOT |
demonstrated,demonstrated |
R8038 |
T10474 |
T10473 |
pobj |
BMP-6,of |
R8039 |
T10475 |
T10478 |
aux |
could,neutralized |
R8040 |
T10476 |
T10478 |
auxpass |
be,neutralized |
R8041 |
T10372 |
T10375 |
det |
a,effect |
R8042 |
T10477 |
T10478 |
advmod |
completely,neutralized |
R8043 |
T10478 |
T10478 |
ROOT |
neutralized,neutralized |
R8044 |
T10373 |
T10375 |
amod |
significant,effect |
R8045 |
T10374 |
T10375 |
amod |
antiproliferative,effect |
R8046 |
T10375 |
T10371 |
dobj |
effect,demonstrated |
R8047 |
T10479 |
T10478 |
agent |
by,neutralized |
R8048 |
T10376 |
T10375 |
prep |
of,effect |
R8049 |
T10480 |
T10481 |
det |
the,use |
R8050 |
T10481 |
T10479 |
pobj |
use,by |
R8051 |
T10377 |
T10376 |
pobj |
BMP-6,of |
R8052 |
T10482 |
T10481 |
prep |
of,use |
R8053 |
T10483 |
T10485 |
det |
a,inhibitor |
R8054 |
T10484 |
T10485 |
amod |
natural,inhibitor |
R8055 |
T10378 |
T10377 |
prep |
in,BMP-6 |
R8056 |
T10485 |
T10482 |
pobj |
inhibitor,of |
R8057 |
T10486 |
T10481 |
punct |
",",use |
R8058 |
T10379 |
T10380 |
amod |
peripheral,blood |
R8059 |
T10487 |
T10481 |
appos |
Noggin,use |
R8060 |
T10488 |
T10478 |
punct |
.,neutralized |
R8061 |
T10489 |
T10490 |
nsubj |
This,is |
R8062 |
T10490 |
T10490 |
ROOT |
is,is |
R8063 |
T10491 |
T10490 |
prep |
in,is |
R8064 |
T10380 |
T10384 |
compound |
blood,cells |
R8065 |
T10492 |
T10491 |
pobj |
line,in |
R8066 |
T10493 |
T10492 |
prep |
with,line |
R8067 |
T10494 |
T10493 |
pobj |
others,with |
R8068 |
T10495 |
T10490 |
punct |
",",is |
R8069 |
T10381 |
T10383 |
compound |
CD19,B |
R8070 |
T10496 |
T10490 |
advcl |
showing,is |
R8071 |
T10497 |
T10500 |
mark |
that,function |
R8072 |
T10382 |
T10383 |
compound |
+,B |
R8073 |
T10498 |
T10500 |
nsubj |
Noggin,function |
R8074 |
T10499 |
T10500 |
aux |
can,function |
R8075 |
T10500 |
T10496 |
ccomp |
function,showing |
R8076 |
T10541 |
T10547 |
punct |
",",demonstrated |
R8077 |
T10501 |
T10500 |
prep |
as,function |
R8078 |
T10502 |
T10504 |
det |
a,antagonist |
R8079 |
T10542 |
T10543 |
amod |
bifunctional,effects |
R8080 |
T10543 |
T10547 |
nsubj |
effects,demonstrated |
R8081 |
T10503 |
T10504 |
compound |
BMP-6,antagonist |
R8082 |
T10504 |
T10501 |
pobj |
antagonist,as |
R8083 |
T10505 |
T10507 |
compound |
[,] |
R8084 |
T10544 |
T10547 |
aux |
have,demonstrated |
R8085 |
T10506 |
T10507 |
compound |
"21,22",] |
R8086 |
T10507 |
T10504 |
appos |
],antagonist |
R8087 |
T10545 |
T10547 |
advmod |
also,demonstrated |
R8088 |
T10508 |
T10490 |
punct |
.,is |
R8089 |
T10509 |
T10522 |
prep |
In,neutralized |
R8090 |
T10546 |
T10547 |
auxpass |
been,demonstrated |
R8091 |
T10510 |
T10509 |
pobj |
addition,In |
R8092 |
T10511 |
T10522 |
punct |
",",neutralized |
R8093 |
T10512 |
T10513 |
det |
the,combination |
R8094 |
T10547 |
T10547 |
ROOT |
demonstrated,demonstrated |
R8095 |
T10513 |
T10522 |
nsubj |
combination,neutralized |
R8096 |
T10514 |
T10513 |
prep |
of,combination |
R8097 |
T10548 |
T10547 |
prep |
for,demonstrated |
R8098 |
T10515 |
T10520 |
amod |
soluble,proteins |
R8099 |
T10516 |
T10519 |
nmod |
BMP-RIB-Fc,fusion |
R8100 |
T10517 |
T10516 |
cc |
and,BMP-RIB-Fc |
R8101 |
T10549 |
T10548 |
pobj |
BMPs,for |
R8102 |
T10518 |
T10516 |
conj |
BMP-RII-Fc,BMP-RIB-Fc |
R8103 |
T10519 |
T10520 |
compound |
fusion,proteins |
R8104 |
T10520 |
T10514 |
pobj |
proteins,of |
R8105 |
T10550 |
T10547 |
punct |
.,demonstrated |
R8106 |
T10521 |
T10522 |
advmod |
also,neutralized |
R8107 |
T10522 |
T10522 |
ROOT |
neutralized,neutralized |
R8108 |
T10523 |
T10525 |
det |
the,effect |
R8109 |
T10551 |
T10558 |
mark |
Whereas,shown |
R8110 |
T10524 |
T10525 |
amod |
anti-proliferative,effect |
R8111 |
T10525 |
T10522 |
dobj |
effect,neutralized |
R8112 |
T10526 |
T10525 |
prep |
of,effect |
R8113 |
T10527 |
T10526 |
pobj |
BMP-6,of |
R8114 |
T10528 |
T10522 |
prep |
in,neutralized |
R8115 |
T10552 |
T10558 |
nsubjpass |
several,shown |
R8116 |
T10529 |
T10531 |
amod |
human,cells |
R8117 |
T10530 |
T10531 |
compound |
B,cells |
R8118 |
T10553 |
T10552 |
prep |
of,several |
R8119 |
T10554 |
T10555 |
det |
the,BMPs |
R8120 |
T10531 |
T10528 |
pobj |
cells,in |
R8121 |
T10555 |
T10553 |
pobj |
BMPs,of |
R8122 |
T10532 |
T10522 |
punct |
.,neutralized |
R8123 |
T10533 |
T10547 |
advmod |
Interestingly,demonstrated |
R8124 |
T10556 |
T10558 |
aux |
have,shown |
R8125 |
T10534 |
T10547 |
punct |
",",demonstrated |
R8126 |
T10535 |
T10547 |
prep |
as,demonstrated |
R8127 |
T10536 |
T10535 |
prep |
for,as |
R8128 |
T10537 |
T10540 |
amod |
other,members |
R8129 |
T10557 |
T10558 |
auxpass |
been,shown |
R8130 |
T10538 |
T10540 |
compound |
TGF,members |
R8131 |
T10539 |
T10540 |
compound |
family,members |
R8132 |
T10540 |
T10536 |
pobj |
members,for |
R8133 |
T10558 |
T10591 |
advcl |
shown,reported |
R8134 |
T10559 |
T10560 |
aux |
to,promote |
R8135 |
T10560 |
T10558 |
xcomp |
promote,shown |
R8136 |
T10575 |
T10578 |
nmod |
],cells |
R8137 |
T10576 |
T10575 |
cc |
and,] |
R8138 |
T10561 |
T10560 |
dobj |
proliferation,promote |
R8139 |
T10577 |
T10575 |
conj |
granulosa,] |
R8140 |
T10578 |
T10591 |
nsubjpass |
cells,reported |
R8141 |
T10562 |
T10560 |
prep |
in,promote |
R8142 |
T10579 |
T10581 |
nmod |
[,] |
R8143 |
T10580 |
T10581 |
nummod |
25,] |
R8144 |
T10563 |
T10565 |
amod |
various,types |
R8145 |
T10581 |
T10578 |
dobj |
],cells |
R8146 |
T10564 |
T10565 |
compound |
cell,types |
R8147 |
T10565 |
T10562 |
pobj |
types,in |
R8148 |
T10582 |
T10581 |
punct |
",",] |
R8149 |
T10583 |
T10584 |
amod |
antiproliferative,effects |
R8150 |
T10566 |
T10565 |
prep |
including,types |
R8151 |
T10584 |
T10581 |
conj |
effects,] |
R8152 |
T10585 |
T10584 |
cc |
and,effects |
R8153 |
T10567 |
T10568 |
nmod |
condrocytes,[ |
R8154 |
T10586 |
T10584 |
conj |
induction,effects |
R8155 |
T10587 |
T10586 |
prep |
of,induction |
R8156 |
T10588 |
T10587 |
pobj |
apoptosis,of |
R8157 |
T10568 |
T10570 |
nmod |
[,] |
R8158 |
T10589 |
T10591 |
aux |
has,reported |
R8159 |
T10590 |
T10591 |
auxpass |
been,reported |
R8160 |
T10591 |
T10591 |
ROOT |
reported,reported |
R8161 |
T10592 |
T10591 |
prep |
for,reported |
R8162 |
T10593 |
T10597 |
nmod |
B,cells |
R8163 |
T10569 |
T10570 |
nummod |
23,] |
R8164 |
T10594 |
T10593 |
cc |
and,B |
R8165 |
T10595 |
T10593 |
conj |
T,B |
R8166 |
T10596 |
T10597 |
compound |
lineage,cells |
R8167 |
T10570 |
T10566 |
pobj |
],including |
R8168 |
T10597 |
T10592 |
pobj |
cells,for |
R8169 |
T10598 |
T10591 |
punct |
.,reported |
R8170 |
T10571 |
T10570 |
punct |
",",] |
R8171 |
T10599 |
T10600 |
amod |
Similar,effects |
R8172 |
T10600 |
T10615 |
nsubjpass |
effects,demonstrated |
R8173 |
T10601 |
T10602 |
mark |
as,demonstrated |
R8174 |
T10572 |
T10578 |
nsubj |
liver,cells |
R8175 |
T10602 |
T10600 |
advcl |
demonstrated,effects |
R8176 |
T10573 |
T10575 |
nmod |
[,] |
R8177 |
T10603 |
T10602 |
prep |
for,demonstrated |
R8178 |
T10574 |
T10575 |
nummod |
24,] |
R8179 |
T10604 |
T10603 |
pobj |
BMP-6,for |
R8180 |
T10605 |
T10604 |
prep |
on,BMP-6 |
R8181 |
T10639 |
T10640 |
auxpass |
been,reported |
R8182 |
T10606 |
T10608 |
amod |
human,cells |
R8183 |
T10607 |
T10608 |
compound |
B,cells |
R8184 |
T10608 |
T10605 |
pobj |
cells,on |
R8185 |
T10609 |
T10602 |
prep |
in,demonstrated |
R8186 |
T10610 |
T10612 |
det |
the,study |
R8187 |
T10611 |
T10612 |
amod |
present,study |
R8188 |
T10640 |
T10640 |
ROOT |
reported,reported |
R8189 |
T10612 |
T10609 |
pobj |
study,in |
R8190 |
T10613 |
T10615 |
punct |
",",demonstrated |
R8191 |
T10614 |
T10615 |
auxpass |
were,demonstrated |
R8192 |
T10641 |
T10642 |
aux |
to,induce |
R8193 |
T10615 |
T10615 |
ROOT |
demonstrated,demonstrated |
R8194 |
T10616 |
T10615 |
prep |
for,demonstrated |
R8195 |
T10617 |
T10616 |
pobj |
BMP-2,for |
R8196 |
T10642 |
T10640 |
xcomp |
induce,reported |
R8197 |
T10618 |
T10617 |
punct |
",",BMP-2 |
R8198 |
T10619 |
T10617 |
appos |
4,BMP-2 |
R8199 |
T10643 |
T10642 |
dobj |
apoptosis,induce |
R8200 |
T10620 |
T10617 |
punct |
",",BMP-2 |
R8201 |
T10621 |
T10617 |
conj |
6,BMP-2 |
R8202 |
T10622 |
T10621 |
cc |
and,6 |
R8203 |
T10644 |
T10643 |
punct |
",",apoptosis |
R8204 |
T10623 |
T10621 |
conj |
-7,6 |
R8205 |
T10624 |
T10623 |
prep |
in,-7 |
R8206 |
T10625 |
T10627 |
amod |
human,cells |
R8207 |
T10645 |
T10643 |
prep |
including,apoptosis |
R8208 |
T10626 |
T10627 |
compound |
myeloma,cells |
R8209 |
T10627 |
T10624 |
pobj |
cells,in |
R8210 |
T10646 |
T10645 |
prep |
in,including |
R8211 |
T10628 |
T10630 |
compound |
[,] |
R8212 |
T10629 |
T10630 |
compound |
9-11,] |
R8213 |
T10630 |
T10617 |
appos |
],BMP-2 |
R8214 |
T10631 |
T10615 |
punct |
.,demonstrated |
R8215 |
T10632 |
T10633 |
amod |
Other,members |
R8216 |
T10633 |
T10640 |
nsubj |
members,reported |
R8217 |
T10647 |
T10649 |
compound |
mouse,lineage |
R8218 |
T10634 |
T10633 |
prep |
of,members |
R8219 |
T10635 |
T10636 |
det |
the,BMP-family |
R8220 |
T10636 |
T10634 |
pobj |
BMP-family,of |
R8221 |
T10648 |
T10649 |
compound |
B,lineage |
R8222 |
T10637 |
T10640 |
aux |
have,reported |
R8223 |
T10638 |
T10640 |
advmod |
also,reported |
R8224 |
T10649 |
T10650 |
compound |
lineage,cells |
R8225 |
T10650 |
T10646 |
pobj |
cells,in |
R8226 |
T10651 |
T10653 |
nmod |
[,] |
R8227 |
T10652 |
T10653 |
nummod |
26,] |
R8228 |
T10653 |
T10645 |
pobj |
],including |
R8229 |
T10671 |
T10683 |
mark |
that,is |
R8230 |
T10672 |
T10673 |
det |
the,role |
R8231 |
T10654 |
T10640 |
punct |
.,reported |
R8232 |
T10673 |
T10683 |
nsubj |
role,is |
R8233 |
T10674 |
T10673 |
prep |
of,role |
R8234 |
T10655 |
T10658 |
advmod |
Additionally,inhibits |
R8235 |
T10675 |
T10674 |
pobj |
BMPs,of |
R8236 |
T10676 |
T10675 |
prep |
in,BMPs |
R8237 |
T10677 |
T10678 |
det |
the,regulation |
R8238 |
T10656 |
T10658 |
punct |
",",inhibits |
R8239 |
T10678 |
T10676 |
pobj |
regulation,in |
R8240 |
T10679 |
T10678 |
prep |
of,regulation |
R8241 |
T10680 |
T10679 |
pobj |
proliferation,of |
R8242 |
T10657 |
T10658 |
nsubj |
BMP-4,inhibits |
R8243 |
T10658 |
T10658 |
ROOT |
inhibits,inhibits |
R8244 |
T10659 |
T10661 |
nmod |
thymocyte,[ |
R8245 |
T10681 |
T10680 |
cc |
and,proliferation |
R8246 |
T10682 |
T10680 |
conj |
apoptosis,proliferation |
R8247 |
T10660 |
T10661 |
compound |
proliferation,[ |
R8248 |
T10683 |
T10670 |
ccomp |
is,suggest |
R8249 |
T10684 |
T10685 |
advmod |
highly,cell |
R8250 |
T10685 |
T10686 |
compound |
cell,type |
R8251 |
T10661 |
T10658 |
dobj |
[,inhibits |
R8252 |
T10686 |
T10687 |
npadvmod |
type,dependent |
R8253 |
T10687 |
T10683 |
acomp |
dependent,is |
R8254 |
T10688 |
T10670 |
punct |
.,suggest |
R8255 |
T10689 |
T10690 |
aux |
To,examine |
R8256 |
T10690 |
T10702 |
advcl |
examine,analysed |
R8257 |
T10662 |
T10663 |
nummod |
6,] |
R8258 |
T10691 |
T10693 |
advmod |
how,exerts |
R8259 |
T10692 |
T10693 |
nsubj |
BMP-6,exerts |
R8260 |
T10693 |
T10690 |
ccomp |
exerts,examine |
R8261 |
T10694 |
T10696 |
poss |
its,effects |
R8262 |
T10695 |
T10696 |
amod |
functional,effects |
R8263 |
T10663 |
T10661 |
appos |
],[ |
R8264 |
T10696 |
T10693 |
dobj |
effects,exerts |
R8265 |
T10697 |
T10696 |
prep |
in,effects |
R8266 |
T10698 |
T10699 |
compound |
B,cells |
R8267 |
T10664 |
T10658 |
punct |
.,inhibits |
R8268 |
T10699 |
T10697 |
pobj |
cells,in |
R8269 |
T10700 |
T10702 |
punct |
",",analysed |
R8270 |
T10701 |
T10702 |
nsubj |
we,analysed |
R8271 |
T10665 |
T10670 |
advcl |
Taken,suggest |
R8272 |
T10702 |
T10702 |
ROOT |
analysed,analysed |
R8273 |
T10703 |
T10705 |
compound |
BMP,expression |
R8274 |
T10666 |
T10665 |
advmod |
together,Taken |
R8275 |
T10704 |
T10705 |
compound |
receptor,expression |
R8276 |
T10705 |
T10702 |
dobj |
expression,analysed |
R8277 |
T10706 |
T10705 |
prep |
by,expression |
R8278 |
T10667 |
T10670 |
punct |
",",suggest |
R8279 |
T10707 |
T10709 |
amod |
western,analysis |
R8280 |
T10708 |
T10709 |
compound |
blot,analysis |
R8281 |
T10668 |
T10669 |
det |
these,data |
R8282 |
T10709 |
T10706 |
pobj |
analysis,by |
R8283 |
T10710 |
T10702 |
punct |
.,analysed |
R8284 |
T10711 |
T10714 |
amod |
Human,cells |
R8285 |
T10669 |
T10670 |
nsubj |
data,suggest |
R8286 |
T10712 |
T10714 |
amod |
peripheral,cells |
R8287 |
T10713 |
T10714 |
compound |
B,cells |
R8288 |
T10714 |
T10716 |
nsubjpass |
cells,found |
R8289 |
T10670 |
T10670 |
ROOT |
suggest,suggest |
R8290 |
T10715 |
T10716 |
auxpass |
were,found |
R8291 |
T10716 |
T10716 |
ROOT |
found,found |
R8292 |
T10717 |
T10718 |
aux |
to,express |
R8293 |
T10737 |
T10723 |
relcl |
signal,receptors |
R8294 |
T10718 |
T10716 |
advcl |
express,found |
R8295 |
T10719 |
T10721 |
det |
the,type |
R8296 |
T10720 |
T10721 |
compound |
BMP,type |
R8297 |
T10738 |
T10737 |
prep |
after,signal |
R8298 |
T10721 |
T10718 |
dobj |
type,express |
R8299 |
T10722 |
T10723 |
nsubj |
I,receptors |
R8300 |
T10723 |
T10721 |
relcl |
receptors,type |
R8301 |
T10739 |
T10738 |
pobj |
binding,after |
R8302 |
T10724 |
T10723 |
dobj |
Act-RIA,receptors |
R8303 |
T10725 |
T10724 |
cc |
and,Act-RIA |
R8304 |
T10740 |
T10739 |
prep |
of,binding |
R8305 |
T10726 |
T10724 |
conj |
BMP-RIB,Act-RIA |
R8306 |
T10727 |
T10726 |
punct |
",",BMP-RIB |
R8307 |
T10728 |
T10726 |
cc |
and,BMP-RIB |
R8308 |
T10729 |
T10730 |
det |
the,type |
R8309 |
T10741 |
T10742 |
amod |
several,BMPs |
R8310 |
T10730 |
T10726 |
conj |
type,BMP-RIB |
R8311 |
T10731 |
T10732 |
compound |
II-receptors,BMP-RII |
R8312 |
T10732 |
T10724 |
conj |
BMP-RII,Act-RIA |
R8313 |
T10733 |
T10732 |
cc |
and,BMP-RII |
R8314 |
T10734 |
T10732 |
conj |
Act-RIIb,BMP-RII |
R8315 |
T10735 |
T10724 |
punct |
",",Act-RIA |
R8316 |
T10736 |
T10737 |
nsubj |
which,signal |
R8317 |
T10742 |
T10740 |
pobj |
BMPs,of |
R8318 |
T10743 |
T10742 |
punct |
",",BMPs |
R8319 |
T10744 |
T10742 |
prep |
including,BMPs |
R8320 |
T10745 |
T10746 |
compound |
BMP-6,[ |
R8321 |
T10746 |
T10744 |
pobj |
[,including |
R8322 |
T10747 |
T10748 |
nummod |
"16,13",] |
R8323 |
T10748 |
T10746 |
appos |
],[ |
R8324 |
T10834 |
T10838 |
nsubjpass |
BMP-2,shown |
R8325 |
T10835 |
T10838 |
aux |
has,shown |
R8326 |
T10749 |
T10716 |
punct |
.,found |
R8327 |
T10836 |
T10838 |
advmod |
also,shown |
R8328 |
T10837 |
T10838 |
auxpass |
been,shown |
R8329 |
T10750 |
T10752 |
aux |
To,explore |
R8330 |
T10838 |
T10838 |
ROOT |
shown,shown |
R8331 |
T10839 |
T10840 |
aux |
to,induce |
R8332 |
T10840 |
T10838 |
xcomp |
induce,shown |
R8333 |
T10751 |
T10752 |
advmod |
further,explore |
R8334 |
T10841 |
T10840 |
dobj |
phosphorylation,induce |
R8335 |
T10842 |
T10841 |
prep |
of,phosphorylation |
R8336 |
T10752 |
T10761 |
advcl |
explore,is |
R8337 |
T10843 |
T10846 |
nummod |
p38,] |
R8338 |
T10844 |
T10846 |
nmod |
[,] |
R8339 |
T10845 |
T10846 |
nummod |
29,] |
R8340 |
T10846 |
T10842 |
pobj |
],of |
R8341 |
T10753 |
T10754 |
nsubj |
BMP-6,induced |
R8342 |
T10847 |
T10838 |
punct |
.,shown |
R8343 |
T10848 |
T10857 |
advmod |
Thus,represent |
R8344 |
T10754 |
T10761 |
advcl |
induced,is |
R8345 |
T10849 |
T10857 |
punct |
",",represent |
R8346 |
T10850 |
T10857 |
nsubj |
phosphorylation,represent |
R8347 |
T10851 |
T10850 |
prep |
of,phosphorylation |
R8348 |
T10755 |
T10754 |
prt |
signalling,induced |
R8349 |
T10852 |
T10851 |
pobj |
p38,of |
R8350 |
T10853 |
T10850 |
punct |
",",phosphorylation |
R8351 |
T10854 |
T10850 |
conj |
STAT3,phosphorylation |
R8352 |
T10756 |
T10755 |
punct |
",",signalling |
R8353 |
T10855 |
T10854 |
cc |
and,STAT3 |
R8354 |
T10856 |
T10854 |
conj |
Smad1/5/8,STAT3 |
R8355 |
T10757 |
T10761 |
nsubj |
activation,is |
R8356 |
T10857 |
T10857 |
ROOT |
represent,represent |
R8357 |
T10858 |
T10860 |
amod |
important,pathways |
R8358 |
T10859 |
T10860 |
amod |
BMP-signalling,pathways |
R8359 |
T10758 |
T10757 |
prep |
of,activation |
R8360 |
T10860 |
T10857 |
dobj |
pathways,represent |
R8361 |
T10861 |
T10862 |
nsubj |
that,mediated |
R8362 |
T10862 |
T10860 |
relcl |
mediated,pathways |
R8363 |
T10863 |
T10864 |
det |
the,effects |
R8364 |
T10864 |
T10862 |
dobj |
effects,mediated |
R8365 |
T10865 |
T10864 |
prep |
of,effects |
R8366 |
T10759 |
T10760 |
amod |
several,pathways |
R8367 |
T10866 |
T10865 |
pobj |
BMPs,of |
R8368 |
T10867 |
T10866 |
cc |
and,BMPs |
R8369 |
T10868 |
T10869 |
advmod |
even,cross-talk |
R8370 |
T10760 |
T10758 |
pobj |
pathways,of |
R8371 |
T10869 |
T10862 |
npadvmod |
cross-talk,mediated |
R8372 |
T10870 |
T10869 |
prep |
between,cross-talk |
R8373 |
T10871 |
T10872 |
det |
these,pathways |
R8374 |
T10761 |
T10761 |
ROOT |
is,is |
R8375 |
T10872 |
T10870 |
pobj |
pathways,between |
R8376 |
T10873 |
T10875 |
aux |
has,reported |
R8377 |
T10874 |
T10875 |
auxpass |
been,reported |
R8378 |
T10762 |
T10761 |
acomp |
possible,is |
R8379 |
T10875 |
T10857 |
conj |
reported,represent |
R8380 |
T10876 |
T10878 |
compound |
[,] |
R8381 |
T10763 |
T10761 |
punct |
.,is |
R8382 |
T10877 |
T10878 |
compound |
"29,30",] |
R8383 |
T10878 |
T10875 |
oprd |
],reported |
R8384 |
T10879 |
T10857 |
punct |
.,represent |
R8385 |
T10764 |
T10767 |
det |
The,pathway |
R8386 |
T10880 |
T10886 |
prep |
In,were |
R8387 |
T10881 |
T10883 |
det |
the,study |
R8388 |
T10882 |
T10883 |
amod |
present,study |
R8389 |
T10765 |
T10767 |
amod |
major,pathway |
R8390 |
T10883 |
T10880 |
pobj |
study,In |
R8391 |
T10884 |
T10886 |
punct |
",",were |
R8392 |
T10885 |
T10886 |
nsubj |
we,were |
R8393 |
T10766 |
T10767 |
amod |
signalling,pathway |
R8394 |
T10886 |
T10886 |
ROOT |
were,were |
R8395 |
T10887 |
T10886 |
neg |
not,were |
R8396 |
T10888 |
T10886 |
acomp |
able,were |
R8397 |
T10767 |
T10772 |
nsubj |
pathway,is |
R8398 |
T10889 |
T10890 |
aux |
to,detect |
R8399 |
T10890 |
T10888 |
xcomp |
detect,able |
R8400 |
T10891 |
T10892 |
amod |
BMP-6-induced,changes |
R8401 |
T10768 |
T10767 |
acl |
known,pathway |
R8402 |
T10892 |
T10890 |
dobj |
changes,detect |
R8403 |
T10893 |
T10890 |
prep |
in,detect |
R8404 |
T10894 |
T10896 |
det |
the,status |
R8405 |
T10895 |
T10896 |
compound |
phosphorylation,status |
R8406 |
T10769 |
T10768 |
prep |
to,known |
R8407 |
T10896 |
T10893 |
pobj |
status,in |
R8408 |
T10897 |
T10896 |
prep |
of,status |
R8409 |
T10770 |
T10769 |
pobj |
date,to |
R8410 |
T10898 |
T10897 |
pobj |
STAT3,of |
R8411 |
T10899 |
T10898 |
cc |
or,STAT3 |
R8412 |
T10771 |
T10767 |
punct |
",",pathway |
R8413 |
T10900 |
T10898 |
conj |
p38,STAT3 |
R8414 |
T10901 |
T10896 |
prep |
in,status |
R8415 |
T10902 |
T10905 |
amod |
human,cells |
R8416 |
T10772 |
T10772 |
ROOT |
is,is |
R8417 |
T10903 |
T10905 |
amod |
peripheral,cells |
R8418 |
T10904 |
T10905 |
compound |
B,cells |
R8419 |
T10773 |
T10772 |
attr |
activation,is |
R8420 |
T10905 |
T10901 |
pobj |
cells,in |
R8421 |
T10906 |
T10886 |
punct |
.,were |
R8422 |
T10907 |
T10917 |
advmod |
Instead,revealed |
R8423 |
T10774 |
T10773 |
prep |
of,activation |
R8424 |
T10908 |
T10917 |
punct |
",",revealed |
R8425 |
T10909 |
T10913 |
det |
a,phosphorylation |
R8426 |
T10775 |
T10774 |
pobj |
R-Smads,of |
R8427 |
T10910 |
T10913 |
amod |
rapid,phosphorylation |
R8428 |
T10911 |
T10910 |
cc |
and,rapid |
R8429 |
T10912 |
T10910 |
conj |
marked,rapid |
R8430 |
T10776 |
T10778 |
compound |
[,] |
R8431 |
T10913 |
T10917 |
nsubjpass |
phosphorylation,revealed |
R8432 |
T10914 |
T10913 |
prep |
of,phosphorylation |
R8433 |
T10915 |
T10914 |
pobj |
Smad1/5/8,of |
R8434 |
T10777 |
T10778 |
compound |
"13,27",] |
R8435 |
T10778 |
T10773 |
appos |
],activation |
R8436 |
T10916 |
T10917 |
auxpass |
was,revealed |
R8437 |
T10779 |
T10772 |
punct |
.,is |
R8438 |
T10917 |
T10917 |
ROOT |
revealed,revealed |
R8439 |
T10918 |
T10917 |
punct |
.,revealed |
R8440 |
T10780 |
T10787 |
prep |
In,shown |
R8441 |
T10919 |
T10926 |
prep |
In,found |
R8442 |
T10920 |
T10922 |
det |
a,study |
R8443 |
T10921 |
T10922 |
amod |
parallel,study |
R8444 |
T10781 |
T10782 |
det |
that,respect |
R8445 |
T10922 |
T10919 |
pobj |
study,In |
R8446 |
T10923 |
T10926 |
punct |
",",found |
R8447 |
T10782 |
T10780 |
pobj |
respect,In |
R8448 |
T10924 |
T10926 |
nsubj |
we,found |
R8449 |
T10925 |
T10926 |
aux |
have,found |
R8450 |
T10783 |
T10787 |
punct |
",",shown |
R8451 |
T10926 |
T10926 |
ROOT |
found,found |
R8452 |
T10927 |
T10931 |
mark |
that,induced |
R8453 |
T10784 |
T10787 |
nsubjpass |
BMPs,shown |
R8454 |
T10928 |
T10929 |
amod |
other,BMPs |
R8455 |
T10929 |
T10931 |
nsubj |
BMPs,induced |
R8456 |
T10785 |
T10787 |
aux |
have,shown |
R8457 |
T10930 |
T10931 |
advmod |
also,induced |
R8458 |
T10786 |
T10787 |
auxpass |
been,shown |
R8459 |
T10787 |
T10787 |
ROOT |
shown,shown |
R8460 |
T10788 |
T10789 |
aux |
to,exert |
R8461 |
T10931 |
T10926 |
ccomp |
induced,found |
R8462 |
T10932 |
T10931 |
dobj |
phosphorylation,induced |
R8463 |
T10933 |
T10932 |
prep |
of,phosphorylation |
R8464 |
T10934 |
T10933 |
pobj |
Smad1/5/8,of |
R8465 |
T10789 |
T10787 |
xcomp |
exert,shown |
R8466 |
T10935 |
T10932 |
prep |
in,phosphorylation |
R8467 |
T10936 |
T10938 |
amod |
peripheral,cells |
R8468 |
T10790 |
T10791 |
amod |
antiproliferative,effects |
R8469 |
T10937 |
T10938 |
compound |
B,cells |
R8470 |
T10938 |
T10935 |
pobj |
cells,in |
R8471 |
T10939 |
T10942 |
punct |
(,shown |
R8472 |
T10791 |
T10789 |
dobj |
effects,exert |
R8473 |
T10940 |
T10942 |
nsubjpass |
data,shown |
R8474 |
T10941 |
T10942 |
neg |
not,shown |
R8475 |
T10942 |
T10931 |
parataxis |
shown,induced |
R8476 |
T10792 |
T10791 |
prep |
in,effects |
R8477 |
T10943 |
T10942 |
punct |
),shown |
R8478 |
T10944 |
T10926 |
punct |
.,found |
R8479 |
T10793 |
T10794 |
compound |
B,lineage |
R8480 |
T10945 |
T10948 |
nsubj |
We,pursuing |
R8481 |
T10946 |
T10948 |
aux |
are,pursuing |
R8482 |
T10947 |
T10948 |
advmod |
currently,pursuing |
R8483 |
T10794 |
T10795 |
compound |
lineage,cells |
R8484 |
T10948 |
T10948 |
ROOT |
pursuing,pursuing |
R8485 |
T10949 |
T10950 |
compound |
microarray,studies |
R8486 |
T10795 |
T10792 |
pobj |
cells,in |
R8487 |
T10950 |
T10948 |
dobj |
studies,pursuing |
R8488 |
T10951 |
T10952 |
aux |
to,identify |
R8489 |
T10952 |
T10948 |
advcl |
identify,pursuing |
R8490 |
T10796 |
T10789 |
prep |
via,exert |
R8491 |
T10953 |
T10955 |
det |
the,pathways |
R8492 |
T10954 |
T10955 |
amod |
signalling,pathways |
R8493 |
T10955 |
T10952 |
dobj |
pathways,identify |
R8494 |
T10797 |
T10796 |
pobj |
phosphorylation,via |
R8495 |
T10956 |
T10955 |
cc |
and,pathways |
R8496 |
T10957 |
T10958 |
compound |
target,genes |
R8497 |
T10958 |
T10955 |
conj |
genes,pathways |
R8498 |
T10798 |
T10797 |
prep |
of,phosphorylation |
R8499 |
T10959 |
T10962 |
nsubjpass |
that,regulated |
R8500 |
T10960 |
T10962 |
auxpass |
are,regulated |
R8501 |
T10961 |
T10962 |
advmod |
differently,regulated |
R8502 |
T10962 |
T10955 |
relcl |
regulated,pathways |
R8503 |
T10799 |
T10802 |
amod |
R-Smad,] |
R8504 |
T10963 |
T10962 |
agent |
by,regulated |
R8505 |
T10964 |
T10966 |
det |
the,BMPs |
R8506 |
T10800 |
T10802 |
compound |
[,] |
R8507 |
T10965 |
T10966 |
amod |
various,BMPs |
R8508 |
T10966 |
T10963 |
pobj |
BMPs,by |
R8509 |
T10967 |
T10966 |
prep |
in,BMPs |
R8510 |
T10801 |
T10802 |
compound |
"11,28",] |
R8511 |
T10968 |
T10970 |
amod |
human,cells |
R8512 |
T10969 |
T10970 |
compound |
B,cells |
R8513 |
T10970 |
T10967 |
pobj |
cells,in |
R8514 |
T10971 |
T10948 |
punct |
.,pursuing |
R8515 |
T10972 |
T10978 |
nsubj |
Upregulation,is |
R8516 |
T10973 |
T10972 |
prep |
of,Upregulation |
R8517 |
T10802 |
T10798 |
pobj |
],of |
R8518 |
T10974 |
T10973 |
pobj |
Id1,of |
R8519 |
T10975 |
T10972 |
prep |
via,Upregulation |
R8520 |
T10976 |
T10977 |
compound |
Smad1/5/8,phosphorylation |
R8521 |
T10803 |
T10787 |
punct |
.,shown |
R8522 |
T10977 |
T10975 |
pobj |
phosphorylation,via |
R8523 |
T10978 |
T10978 |
ROOT |
is,is |
R8524 |
T10804 |
T10809 |
advmod |
Furthermore,shown |
R8525 |
T10805 |
T10809 |
punct |
",",shown |
R8526 |
T10979 |
T10981 |
det |
a,mechanism |
R8527 |
T10980 |
T10981 |
amod |
known,mechanism |
R8528 |
T10806 |
T10809 |
nsubjpass |
BMP-2,shown |
R8529 |
T10981 |
T10978 |
attr |
mechanism,is |
R8530 |
T10982 |
T10981 |
prep |
for,mechanism |
R8531 |
T10807 |
T10809 |
aux |
has,shown |
R8532 |
T10983 |
T10984 |
nsubj |
BMP-6,signalling |
R8533 |
T10984 |
T10982 |
pcomp |
signalling,for |
R8534 |
T10985 |
T10984 |
prep |
in,signalling |
R8535 |
T10808 |
T10809 |
auxpass |
been,shown |
R8536 |
T10986 |
T10988 |
amod |
other,systems |
R8537 |
T10987 |
T10988 |
compound |
cell,systems |
R8538 |
T10988 |
T10985 |
pobj |
systems,in |
R8539 |
T10809 |
T10809 |
ROOT |
shown,shown |
R8540 |
T10989 |
T10991 |
compound |
[,] |
R8541 |
T10990 |
T10991 |
compound |
"31,32",] |
R8542 |
T10991 |
T10984 |
dobj |
],signalling |
R8543 |
T10810 |
T10811 |
aux |
to,induce |
R8544 |
T10992 |
T10991 |
cc |
and,] |
R8545 |
T10993 |
T10991 |
conj |
regulation,] |
R8546 |
T10811 |
T10809 |
xcomp |
induce,shown |
R8547 |
T10812 |
T10811 |
dobj |
activation,induce |
R8548 |
T10813 |
T10812 |
prep |
of,activation |
R8549 |
T10994 |
T10993 |
prep |
of,regulation |
R8550 |
T10995 |
T10994 |
pobj |
Id-proteins,of |
R8551 |
T10814 |
T10813 |
pobj |
STAT3,of |
R8552 |
T10996 |
T10997 |
auxpass |
is,thought |
R8553 |
T10997 |
T10978 |
conj |
thought,is |
R8554 |
T10815 |
T10812 |
prep |
in,activation |
R8555 |
T10998 |
T10999 |
aux |
to,be |
R8556 |
T10999 |
T10997 |
xcomp |
be,thought |
R8557 |
T11000 |
T11002 |
det |
an,mechanism |
R8558 |
T10816 |
T10817 |
compound |
myeloma,cells |
R8559 |
T11001 |
T11002 |
amod |
important,mechanism |
R8560 |
T11002 |
T10999 |
attr |
mechanism,be |
R8561 |
T11003 |
T11002 |
prep |
for,mechanism |
R8562 |
T10817 |
T10815 |
pobj |
cells,in |
R8563 |
T11004 |
T11005 |
compound |
Smad-signalling,[ |
R8564 |
T11005 |
T11007 |
nmod |
[,] |
R8565 |
T11006 |
T11007 |
nummod |
17,] |
R8566 |
T11007 |
T11003 |
pobj |
],for |
R8567 |
T11008 |
T10978 |
punct |
.,is |
R8568 |
T11009 |
T11017 |
prep |
In,revealed |
R8569 |
T10818 |
T10820 |
nmod |
[,] |
R8570 |
T11010 |
T11012 |
det |
the,study |
R8571 |
T11011 |
T11012 |
amod |
present,study |
R8572 |
T11012 |
T11009 |
pobj |
study,In |
R8573 |
T10819 |
T10820 |
nummod |
9,] |
R8574 |
T11013 |
T11017 |
punct |
",",revealed |
R8575 |
T11014 |
T11016 |
amod |
real-time,experiments |
R8576 |
T10820 |
T10809 |
dobj |
],shown |
R8577 |
T11015 |
T11016 |
compound |
RT-PCR,experiments |
R8578 |
T11016 |
T11017 |
nsubj |
experiments,revealed |
R8579 |
T11017 |
T11017 |
ROOT |
revealed,revealed |
R8580 |
T10821 |
T10809 |
punct |
.,shown |
R8581 |
T11018 |
T11021 |
det |
a,upregulation |
R8582 |
T11019 |
T11021 |
amod |
specific,upregulation |
R8583 |
T11020 |
T11021 |
advmod |
four-fold,upregulation |
R8584 |
T10822 |
T10829 |
advmod |
However,investigated |
R8585 |
T11021 |
T11017 |
dobj |
upregulation,revealed |
R8586 |
T11022 |
T11021 |
prep |
for,upregulation |
R8587 |
T11023 |
T11022 |
pobj |
Id1,for |
R8588 |
T10823 |
T10829 |
punct |
",",investigated |
R8589 |
T11024 |
T11021 |
prep |
in,upregulation |
R8590 |
T11025 |
T11026 |
compound |
BMP-6-treated,B |
R8591 |
T11026 |
T11027 |
compound |
B,cells |
R8592 |
T10824 |
T10829 |
nsubjpass |
phosphorylation,investigated |
R8593 |
T11027 |
T11024 |
pobj |
cells,in |
R8594 |
T10825 |
T10824 |
prep |
of,phosphorylation |
R8595 |
T10826 |
T10825 |
pobj |
R-Smad,of |
R8596 |
T10827 |
T10829 |
auxpass |
was,investigated |
R8597 |
T11028 |
T11017 |
punct |
",",revealed |
R8598 |
T11029 |
T11035 |
mark |
while,remained |
R8599 |
T10828 |
T10829 |
neg |
not,investigated |
R8600 |
T11030 |
T11031 |
det |
the,amount |
R8601 |
T11031 |
T11035 |
nsubj |
amount,remained |
R8602 |
T10829 |
T10829 |
ROOT |
investigated,investigated |
R8603 |
T11032 |
T11031 |
prep |
of,amount |
R8604 |
T11033 |
T11032 |
pobj |
Id2,of |
R8605 |
T11034 |
T11035 |
nsubj |
Id4,remained |
R8606 |
T10830 |
T10829 |
prep |
in,investigated |
R8607 |
T11035 |
T11017 |
advcl |
remained,revealed |
R8608 |
T11036 |
T11035 |
acomp |
unchanged,remained |
R8609 |
T10831 |
T10832 |
det |
that,study |
R8610 |
T11037 |
T11017 |
punct |
.,revealed |
R8611 |
T11038 |
T11046 |
prep |
In,demonstrated |
R8612 |
T11039 |
T11038 |
pobj |
agreement,In |
R8613 |
T11040 |
T11039 |
prep |
with,agreement |
R8614 |
T11041 |
T11040 |
pobj |
this,with |
R8615 |
T11042 |
T11046 |
punct |
",",demonstrated |
R8616 |
T11043 |
T11045 |
amod |
western,analysis |
R8617 |
T11044 |
T11045 |
compound |
blot,analysis |
R8618 |
T10832 |
T10830 |
pobj |
study,in |
R8619 |
T11045 |
T11046 |
nsubj |
analysis,demonstrated |
R8620 |
T11046 |
T11046 |
ROOT |
demonstrated,demonstrated |
R8621 |
T11047 |
T11048 |
det |
an,upregulation |
R8622 |
T10833 |
T10829 |
punct |
.,investigated |
R8623 |
T11048 |
T11046 |
dobj |
upregulation,demonstrated |
R8624 |
T11049 |
T11048 |
prep |
of,upregulation |
R8625 |
T11050 |
T11051 |
amod |
Id1,protein |
R8626 |
T11051 |
T11049 |
pobj |
protein,of |
R8627 |
T11125 |
T11123 |
pobj |
interest,of |
R8628 |
T11052 |
T11046 |
punct |
",",demonstrated |
R8629 |
T11053 |
T11062 |
mark |
while,remained |
R8630 |
T11054 |
T11055 |
det |
the,amount |
R8631 |
T11055 |
T11062 |
nsubj |
amount,remained |
R8632 |
T11056 |
T11055 |
prep |
of,amount |
R8633 |
T11126 |
T11122 |
punct |
.,is |
R8634 |
T11057 |
T11056 |
pobj |
Id2,of |
R8635 |
T11127 |
T11132 |
prep |
In,is |
R8636 |
T11058 |
T11057 |
cc |
and,Id2 |
R8637 |
T11128 |
T11129 |
det |
that,respect |
R8638 |
T11059 |
T11057 |
conj |
Id3,Id2 |
R8639 |
T11060 |
T11061 |
compound |
protein,levels |
R8640 |
T11061 |
T11062 |
nsubj |
levels,remained |
R8641 |
T11129 |
T11127 |
pobj |
respect,In |
R8642 |
T11062 |
T11046 |
advcl |
remained,demonstrated |
R8643 |
T11063 |
T11062 |
acomp |
unchanged,remained |
R8644 |
T11130 |
T11132 |
punct |
",",is |
R8645 |
T11064 |
T11046 |
punct |
.,demonstrated |
R8646 |
T11065 |
T11070 |
advmod |
Previously,considered |
R8647 |
T11131 |
T11132 |
nsubj |
it,is |
R8648 |
T11066 |
T11070 |
punct |
",",considered |
R8649 |
T11067 |
T11070 |
nsubjpass |
Id1,considered |
R8650 |
T11068 |
T11070 |
aux |
has,considered |
R8651 |
T11132 |
T11132 |
ROOT |
is,is |
R8652 |
T11069 |
T11070 |
auxpass |
been,considered |
R8653 |
T11070 |
T11070 |
ROOT |
considered,considered |
R8654 |
T11133 |
T11132 |
acomp |
noteworthy,is |
R8655 |
T11071 |
T11074 |
neg |
not,expressed |
R8656 |
T11072 |
T11074 |
aux |
to,expressed |
R8657 |
T11134 |
T11143 |
mark |
that,induces |
R8658 |
T11135 |
T11136 |
amod |
TGF-β,signalling |
R8659 |
T11073 |
T11074 |
auxpass |
be,expressed |
R8660 |
T11074 |
T11070 |
xcomp |
expressed,considered |
R8661 |
T11075 |
T11074 |
prep |
in,expressed |
R8662 |
T11136 |
T11143 |
nsubj |
signalling,induces |
R8663 |
T11076 |
T11078 |
amod |
later,stages |
R8664 |
T11077 |
T11078 |
amod |
developmental,stages |
R8665 |
T11078 |
T11075 |
pobj |
stages,in |
R8666 |
T11079 |
T11074 |
prep |
than,expressed |
R8667 |
T11080 |
T11081 |
amod |
pro-B,cells |
R8668 |
T11081 |
T11079 |
pobj |
cells,than |
R8669 |
T11137 |
T11136 |
prep |
in,signalling |
R8670 |
T11082 |
T11084 |
compound |
[,] |
R8671 |
T11083 |
T11084 |
compound |
"33,34",] |
R8672 |
T11084 |
T11081 |
appos |
],cells |
R8673 |
T11138 |
T11142 |
amod |
early,cells |
R8674 |
T11085 |
T11084 |
punct |
",",] |
R8675 |
T11086 |
T11084 |
cc |
and,] |
R8676 |
T11139 |
T11138 |
cc |
and,early |
R8677 |
T11087 |
T11089 |
poss |
its,expression |
R8678 |
T11088 |
T11089 |
amod |
constitutive,expression |
R8679 |
T11089 |
T11092 |
nsubjpass |
expression,reported |
R8680 |
T11140 |
T11138 |
conj |
mature,early |
R8681 |
T11090 |
T11092 |
aux |
has,reported |
R8682 |
T11091 |
T11092 |
auxpass |
been,reported |
R8683 |
T11141 |
T11142 |
compound |
B,cells |
R8684 |
T11092 |
T11070 |
conj |
reported,considered |
R8685 |
T11093 |
T11094 |
aux |
to,impair |
R8686 |
T11094 |
T11092 |
xcomp |
impair,reported |
R8687 |
T11095 |
T11098 |
compound |
mouse,development |
R8688 |
T11142 |
T11137 |
pobj |
cells,in |
R8689 |
T11096 |
T11098 |
compound |
B,development |
R8690 |
T11097 |
T11098 |
compound |
cell,development |
R8691 |
T11098 |
T11094 |
dobj |
development,impair |
R8692 |
T11143 |
T11132 |
ccomp |
induces,is |
R8693 |
T11099 |
T11101 |
nmod |
[,] |
R8694 |
T11100 |
T11101 |
nummod |
35,] |
R8695 |
T11144 |
T11145 |
preconj |
both,Id2 |
R8696 |
T11101 |
T11098 |
appos |
],development |
R8697 |
T11102 |
T11092 |
punct |
.,reported |
R8698 |
T11103 |
T11122 |
advmod |
Therefore,is |
R8699 |
T11145 |
T11148 |
amod |
Id2,expression |
R8700 |
T11104 |
T11122 |
punct |
",",is |
R8701 |
T11105 |
T11106 |
poss |
our,demonstration |
R8702 |
T11146 |
T11145 |
cc |
and,Id2 |
R8703 |
T11106 |
T11122 |
nsubj |
demonstration,is |
R8704 |
T11107 |
T11106 |
prep |
of,demonstration |
R8705 |
T11108 |
T11110 |
det |
the,upregulation |
R8706 |
T11147 |
T11145 |
conj |
Id3,Id2 |
R8707 |
T11109 |
T11110 |
amod |
time-dependent,upregulation |
R8708 |
T11110 |
T11107 |
pobj |
upregulation,of |
R8709 |
T11111 |
T11110 |
prep |
of,upregulation |
R8710 |
T11112 |
T11113 |
compound |
Id1,mRNA |
R8711 |
T11148 |
T11151 |
compound |
expression,] |
R8712 |
T11149 |
T11151 |
compound |
[,] |
R8713 |
T11113 |
T11111 |
pobj |
mRNA,of |
R8714 |
T11150 |
T11151 |
compound |
"36,37",] |
R8715 |
T11114 |
T11110 |
cc |
and,upregulation |
R8716 |
T11115 |
T11110 |
conj |
protein,upregulation |
R8717 |
T11116 |
T11110 |
prep |
in,upregulation |
R8718 |
T11117 |
T11121 |
amod |
mature,cells |
R8719 |
T11118 |
T11121 |
amod |
normal,cells |
R8720 |
T11151 |
T11143 |
dobj |
],induces |
R8721 |
T11119 |
T11121 |
amod |
human,cells |
R8722 |
T11120 |
T11121 |
compound |
B,cells |
R8723 |
T11121 |
T11116 |
pobj |
cells,in |
R8724 |
T11122 |
T11122 |
ROOT |
is,is |
R8725 |
T11152 |
T11143 |
punct |
",",induces |
R8726 |
T11123 |
T11122 |
prep |
of,is |
R8727 |
T11124 |
T11125 |
amod |
particular,interest |
R8728 |
T11153 |
T11143 |
cc |
but,induces |
R8729 |
T11154 |
T11155 |
neg |
not,Id1 |
R8730 |
T11155 |
T11143 |
conj |
Id1,induces |
R8731 |
T11156 |
T11159 |
punct |
(,shown |
R8732 |
T11222 |
T11203 |
punct |
.,found |
R8733 |
T11157 |
T11159 |
nsubjpass |
data,shown |
R8734 |
T11223 |
T11228 |
advmod |
However,induce |
R8735 |
T11224 |
T11228 |
punct |
",",induce |
R8736 |
T11158 |
T11159 |
neg |
not,shown |
R8737 |
T11225 |
T11228 |
nsubj |
BMP-6,induce |
R8738 |
T11159 |
T11155 |
parataxis |
shown,Id1 |
R8739 |
T11226 |
T11228 |
aux |
did,induce |
R8740 |
T11227 |
T11228 |
neg |
not,induce |
R8741 |
T11228 |
T11228 |
ROOT |
induce,induce |
R8742 |
T11160 |
T11159 |
punct |
),shown |
R8743 |
T11229 |
T11230 |
amod |
significant,changes |
R8744 |
T11230 |
T11228 |
dobj |
changes,induce |
R8745 |
T11161 |
T11132 |
punct |
.,is |
R8746 |
T11231 |
T11230 |
prep |
in,changes |
R8747 |
T11232 |
T11234 |
det |
the,expression |
R8748 |
T11162 |
T11166 |
advmod |
Interestingly,show |
R8749 |
T11233 |
T11234 |
compound |
protein,expression |
R8750 |
T11234 |
T11231 |
pobj |
expression,in |
R8751 |
T11235 |
T11234 |
prep |
of,expression |
R8752 |
T11163 |
T11166 |
punct |
",",show |
R8753 |
T11236 |
T11235 |
pobj |
Id2,of |
R8754 |
T11237 |
T11236 |
cc |
and,Id2 |
R8755 |
T11238 |
T11236 |
conj |
Id3,Id2 |
R8756 |
T11164 |
T11165 |
det |
these,results |
R8757 |
T11239 |
T11228 |
punct |
.,induce |
R8758 |
T11240 |
T11242 |
nsubjpass |
It,believed |
R8759 |
T11241 |
T11242 |
auxpass |
is,believed |
R8760 |
T11165 |
T11166 |
nsubj |
results,show |
R8761 |
T11242 |
T11242 |
ROOT |
believed,believed |
R8762 |
T11243 |
T11246 |
mark |
that,block |
R8763 |
T11244 |
T11246 |
advmod |
Id,block |
R8764 |
T11166 |
T11166 |
ROOT |
show,show |
R8765 |
T11245 |
T11246 |
nsubj |
proteins,block |
R8766 |
T11246 |
T11242 |
ccomp |
block,believed |
R8767 |
T11247 |
T11246 |
dobj |
differentiation,block |
R8768 |
T11248 |
T11246 |
cc |
and,block |
R8769 |
T11249 |
T11246 |
conj |
promote,block |
R8770 |
T11250 |
T11249 |
dobj |
proliferation,promote |
R8771 |
T11167 |
T11174 |
mark |
that,regulate |
R8772 |
T11251 |
T11249 |
prep |
in,promote |
R8773 |
T11252 |
T11254 |
amod |
various,types |
R8774 |
T11168 |
T11169 |
amod |
various,members |
R8775 |
T11253 |
T11254 |
compound |
cell,types |
R8776 |
T11254 |
T11251 |
pobj |
types,in |
R8777 |
T11255 |
T11257 |
compound |
[,] |
R8778 |
T11169 |
T11174 |
nsubj |
members,regulate |
R8779 |
T11256 |
T11257 |
compound |
"39,33",] |
R8780 |
T11257 |
T11246 |
npadvmod |
],block |
R8781 |
T11258 |
T11242 |
punct |
.,believed |
R8782 |
T11170 |
T11169 |
prep |
of,members |
R8783 |
T11259 |
T11261 |
advmod |
Id,act |
R8784 |
T11260 |
T11261 |
nsubj |
proteins,act |
R8785 |
T11171 |
T11173 |
det |
the,family |
R8786 |
T11261 |
T11261 |
ROOT |
act,act |
R8787 |
T11262 |
T11261 |
prep |
as,act |
R8788 |
T11263 |
T11264 |
amod |
dominant-negative,inhibitors |
R8789 |
T11264 |
T11262 |
pobj |
inhibitors,as |
R8790 |
T11172 |
T11173 |
compound |
TGF-β,family |
R8791 |
T11265 |
T11264 |
prep |
of,inhibitors |
R8792 |
T11266 |
T11265 |
pobj |
E-proteins,of |
R8793 |
T11173 |
T11170 |
pobj |
family,of |
R8794 |
T11267 |
T11266 |
cc |
and,E-proteins |
R8795 |
T11268 |
T11266 |
conj |
Pax5,E-proteins |
R8796 |
T11269 |
T11261 |
conj |
function,act |
R8797 |
T11270 |
T11269 |
prep |
by,function |
R8798 |
T11174 |
T11166 |
ccomp |
regulate,show |
R8799 |
T11271 |
T11270 |
pcomp |
forming,by |
R8800 |
T11272 |
T11271 |
dobj |
dimers,forming |
R8801 |
T11175 |
T11176 |
compound |
Id,proteins |
R8802 |
T11273 |
T11271 |
prep |
with,forming |
R8803 |
T11274 |
T11275 |
det |
these,proteins |
R8804 |
T11176 |
T11174 |
dobj |
proteins,regulate |
R8805 |
T11275 |
T11273 |
pobj |
proteins,with |
R8806 |
T11276 |
T11271 |
punct |
",",forming |
R8807 |
T11277 |
T11271 |
advcl |
making,forming |
R8808 |
T11177 |
T11174 |
advmod |
differently,regulate |
R8809 |
T11278 |
T11279 |
nsubj |
them,unable |
R8810 |
T11279 |
T11277 |
ccomp |
unable,making |
R8811 |
T11178 |
T11166 |
punct |
.,show |
R8812 |
T11280 |
T11281 |
aux |
to,bind |
R8813 |
T11281 |
T11279 |
xcomp |
bind,unable |
R8814 |
T11282 |
T11281 |
dobj |
DNA,bind |
R8815 |
T11179 |
T11183 |
nsubjpass |
Id2,considered |
R8816 |
T11283 |
T11261 |
punct |
.,act |
R8817 |
T11284 |
T11287 |
nsubjpass |
It,proposed |
R8818 |
T11285 |
T11287 |
aux |
has,proposed |
R8819 |
T11286 |
T11287 |
auxpass |
been,proposed |
R8820 |
T11287 |
T11287 |
ROOT |
proposed,proposed |
R8821 |
T11288 |
T11299 |
mark |
that,have |
R8822 |
T11180 |
T11179 |
cc |
and,Id2 |
R8823 |
T11289 |
T11290 |
det |
the,balance |
R8824 |
T11290 |
T11299 |
nsubj |
balance,have |
R8825 |
T11291 |
T11290 |
prep |
among,balance |
R8826 |
T11181 |
T11179 |
conj |
Id3,Id2 |
R8827 |
T11292 |
T11291 |
pobj |
E-proteins,among |
R8828 |
T11293 |
T11292 |
punct |
",",E-proteins |
R8829 |
T11182 |
T11183 |
auxpass |
are,considered |
R8830 |
T11294 |
T11292 |
conj |
Pax5,E-proteins |
R8831 |
T11295 |
T11294 |
cc |
and,Pax5 |
R8832 |
T11183 |
T11183 |
ROOT |
considered,considered |
R8833 |
T11296 |
T11297 |
compound |
Id,proteins |
R8834 |
T11184 |
T11185 |
aux |
to,be |
R8835 |
T11297 |
T11294 |
conj |
proteins,Pax5 |
R8836 |
T11298 |
T11299 |
aux |
might,have |
R8837 |
T11185 |
T11183 |
xcomp |
be,considered |
R8838 |
T11299 |
T11287 |
ccomp |
have,proposed |
R8839 |
T11300 |
T11302 |
det |
an,role |
R8840 |
T11186 |
T11188 |
det |
the,proteins |
R8841 |
T11301 |
T11302 |
amod |
important,role |
R8842 |
T11302 |
T11299 |
dobj |
role,have |
R8843 |
T11303 |
T11302 |
prep |
in,role |
R8844 |
T11187 |
T11188 |
compound |
Id,proteins |
R8845 |
T11304 |
T11306 |
amod |
activated,cells |
R8846 |
T11305 |
T11306 |
compound |
B,cells |
R8847 |
T11188 |
T11185 |
attr |
proteins,be |
R8848 |
T11306 |
T11303 |
pobj |
cells,in |
R8849 |
T11307 |
T11309 |
nmod |
[,] |
R8850 |
T11189 |
T11190 |
advmod |
mainly,expressed |
R8851 |
T11190 |
T11188 |
acl |
expressed,proteins |
R8852 |
T11308 |
T11309 |
nummod |
38,] |
R8853 |
T11191 |
T11190 |
prep |
in,expressed |
R8854 |
T11309 |
T11306 |
appos |
],cells |
R8855 |
T11310 |
T11287 |
punct |
.,proposed |
R8856 |
T11311 |
T11318 |
prep |
In,implicated |
R8857 |
T11192 |
T11194 |
amod |
mature,cells |
R8858 |
T11312 |
T11313 |
det |
that,respect |
R8859 |
T11313 |
T11311 |
pobj |
respect,In |
R8860 |
T11193 |
T11194 |
compound |
B,cells |
R8861 |
T11314 |
T11318 |
punct |
",",implicated |
R8862 |
T11315 |
T11318 |
nsubjpass |
E-proteins,implicated |
R8863 |
T11316 |
T11318 |
aux |
have,implicated |
R8864 |
T11194 |
T11191 |
pobj |
cells,in |
R8865 |
T11317 |
T11318 |
auxpass |
been,implicated |
R8866 |
T11318 |
T11318 |
ROOT |
implicated,implicated |
R8867 |
T11195 |
T11197 |
nmod |
[,] |
R8868 |
T11196 |
T11197 |
nummod |
38,] |
R8869 |
T11319 |
T11318 |
prep |
in,implicated |
R8870 |
T11320 |
T11322 |
preconj |
both,promotion |
R8871 |
T11197 |
T11194 |
appos |
],cells |
R8872 |
T11321 |
T11322 |
det |
the,promotion |
R8873 |
T11322 |
T11319 |
pobj |
promotion,in |
R8874 |
T11323 |
T11322 |
cc |
and,promotion |
R8875 |
T11198 |
T11183 |
punct |
.,considered |
R8876 |
T11324 |
T11322 |
conj |
inhibition,promotion |
R8877 |
T11325 |
T11324 |
prep |
of,inhibition |
R8878 |
T11326 |
T11327 |
compound |
cell,survival |
R8879 |
T11199 |
T11201 |
det |
The,study |
R8880 |
T11327 |
T11325 |
pobj |
survival,of |
R8881 |
T11328 |
T11327 |
cc |
and,survival |
R8882 |
T11200 |
T11201 |
amod |
present,study |
R8883 |
T11329 |
T11327 |
conj |
growth,survival |
R8884 |
T11330 |
T11322 |
prep |
at,promotion |
R8885 |
T11331 |
T11332 |
amod |
different,points |
R8886 |
T11201 |
T11203 |
nsubj |
study,found |
R8887 |
T11332 |
T11330 |
pobj |
points,at |
R8888 |
T11333 |
T11322 |
prep |
in,promotion |
R8889 |
T11202 |
T11203 |
advmod |
also,found |
R8890 |
T11334 |
T11335 |
compound |
lymphocyte,development |
R8891 |
T11335 |
T11333 |
pobj |
development,in |
R8892 |
T11336 |
T11338 |
nmod |
[,] |
R8893 |
T11203 |
T11203 |
ROOT |
found,found |
R8894 |
T11337 |
T11338 |
nummod |
40,] |
R8895 |
T11338 |
T11322 |
appos |
],promotion |
R8896 |
T11339 |
T11318 |
punct |
.,implicated |
R8897 |
T11204 |
T11203 |
dobj |
Id2,found |
R8898 |
T11340 |
T11341 |
det |
The,antiproliferative |
R8899 |
T11341 |
T11344 |
nsubj |
antiproliferative,inducing |
R8900 |
T11205 |
T11204 |
cc |
and,Id2 |
R8901 |
T11342 |
T11341 |
cc |
and,antiproliferative |
R8902 |
T11343 |
T11344 |
npadvmod |
death,inducing |
R8903 |
T11344 |
T11357 |
csubj |
inducing,is |
R8904 |
T11206 |
T11207 |
compound |
Id3,protein |
R8905 |
T11345 |
T11344 |
dobj |
effect,inducing |
R8906 |
T11346 |
T11345 |
prep |
of,effect |
R8907 |
T11347 |
T11346 |
pobj |
BMP-6,of |
R8908 |
T11207 |
T11204 |
conj |
protein,Id2 |
R8909 |
T11348 |
T11344 |
prep |
in,inducing |
R8910 |
T11349 |
T11350 |
compound |
B,cells |
R8911 |
T11350 |
T11348 |
pobj |
cells,in |
R8912 |
T11208 |
T11203 |
prep |
in,found |
R8913 |
T11351 |
T11344 |
prep |
with,inducing |
R8914 |
T11352 |
T11353 |
amod |
concomitant,upregulation |
R8915 |
T11353 |
T11351 |
pobj |
upregulation,with |
R8916 |
T11354 |
T11353 |
prep |
of,upregulation |
R8917 |
T11355 |
T11356 |
amod |
Id1,protein |
R8918 |
T11209 |
T11210 |
compound |
B,cells |
R8919 |
T11356 |
T11354 |
pobj |
protein,of |
R8920 |
T11357 |
T11357 |
ROOT |
is,is |
R8921 |
T11358 |
T11359 |
advmod |
therefore,in |
R8922 |
T11210 |
T11208 |
pobj |
cells,in |
R8923 |
T11359 |
T11357 |
prep |
in,is |
R8924 |
T11360 |
T11359 |
pobj |
line,in |
R8925 |
T11211 |
T11212 |
aux |
to,be |
R8926 |
T11361 |
T11360 |
prep |
with,line |
R8927 |
T11362 |
T11363 |
det |
the,view |
R8928 |
T11363 |
T11361 |
pobj |
view,with |
R8929 |
T11212 |
T11203 |
advcl |
be,found |
R8930 |
T11364 |
T11368 |
mark |
that,required |
R8931 |
T11365 |
T11368 |
prep |
Id,required |
R8932 |
T11366 |
T11368 |
nsubjpass |
proteins,required |
R8933 |
T11213 |
T11215 |
advmod |
more,expressed |
R8934 |
T11367 |
T11368 |
auxpass |
are,required |
R8935 |
T11368 |
T11363 |
acl |
required,view |
R8936 |
T11369 |
T11368 |
prep |
for,required |
R8937 |
T11214 |
T11215 |
advmod |
highly,expressed |
R8938 |
T11370 |
T11371 |
det |
the,induction |
R8939 |
T11371 |
T11369 |
pobj |
induction,for |
R8940 |
T11372 |
T11371 |
prep |
of,induction |
R8941 |
T11215 |
T11212 |
acomp |
expressed,be |
R8942 |
T11373 |
T11374 |
compound |
growth,arrest |
R8943 |
T11374 |
T11372 |
pobj |
arrest,of |
R8944 |
T11216 |
T11215 |
prep |
than,expressed |
R8945 |
T11375 |
T11374 |
cc |
and,arrest |
R8946 |
T11376 |
T11374 |
conj |
apoptosis,arrest |
R8947 |
T11217 |
T11216 |
pobj |
Id1,than |
R8948 |
T11218 |
T11217 |
prep |
in,Id1 |
R8949 |
T11377 |
T11371 |
prep |
in,induction |
R8950 |
T11219 |
T11218 |
pcomp |
resting,in |
R8951 |
T11378 |
T11379 |
amod |
B-lymphocyte,progenitors |
R8952 |
T11379 |
T11377 |
pobj |
progenitors,in |
R8953 |
T11220 |
T11221 |
compound |
B,cells |
R8954 |
T11380 |
T11371 |
prep |
by,induction |
R8955 |
T11381 |
T11382 |
compound |
TGF-β,[ |
R8956 |
T11382 |
T11380 |
pobj |
[,by |
R8957 |
T11221 |
T11219 |
dobj |
cells,resting |
R8958 |
T11383 |
T11384 |
nummod |
40,] |
R8959 |
T11384 |
T11382 |
appos |
],[ |
R8960 |
T11385 |
T11357 |
punct |
.,is |
R8961 |
T11416 |
T11422 |
nsubjpass |
members,overexpressed |
R8962 |
T11386 |
T11391 |
advmod |
Furthermore,known |
R8963 |
T11417 |
T11416 |
prep |
of,members |
R8964 |
T11387 |
T11391 |
punct |
",",known |
R8965 |
T11388 |
T11391 |
advmod |
Id,known |
R8966 |
T11418 |
T11420 |
det |
the,family |
R8967 |
T11389 |
T11391 |
nsubjpass |
proteins,known |
R8968 |
T11390 |
T11391 |
auxpass |
are,known |
R8969 |
T11391 |
T11391 |
ROOT |
known,known |
R8970 |
T11392 |
T11391 |
prep |
as,known |
R8971 |
T11393 |
T11394 |
amod |
important,parts |
R8972 |
T11419 |
T11420 |
compound |
Id,family |
R8973 |
T11394 |
T11392 |
pobj |
parts,as |
R8974 |
T11395 |
T11394 |
prep |
of,parts |
R8975 |
T11396 |
T11395 |
pcomp |
signalling,of |
R8976 |
T11420 |
T11417 |
pobj |
family,of |
R8977 |
T11397 |
T11396 |
dobj |
pathways,signalling |
R8978 |
T11398 |
T11397 |
acl |
involved,pathways |
R8979 |
T11399 |
T11398 |
prep |
in,involved |
R8980 |
T11421 |
T11422 |
auxpass |
are,overexpressed |
R8981 |
T11400 |
T11399 |
pobj |
development,in |
R8982 |
T11401 |
T11400 |
punct |
",",development |
R8983 |
T11402 |
T11403 |
compound |
cell,cycle |
R8984 |
T11422 |
T11413 |
ccomp |
overexpressed,established |
R8985 |
T11403 |
T11400 |
conj |
cycle,development |
R8986 |
T11404 |
T11403 |
cc |
and,cycle |
R8987 |
T11405 |
T11406 |
compound |
tumorigenesis,[ |
R8988 |
T11423 |
T11422 |
prep |
in,overexpressed |
R8989 |
T11406 |
T11406 |
ROOT |
[,[ |
R8990 |
T11407 |
T11408 |
nummod |
32,] |
R8991 |
T11408 |
T11391 |
dobj |
],known |
R8992 |
T11424 |
T11425 |
det |
a,range |
R8993 |
T11409 |
T11391 |
punct |
.,known |
R8994 |
T11410 |
T11413 |
nsubjpass |
It,established |
R8995 |
T11425 |
T11423 |
pobj |
range,in |
R8996 |
T11411 |
T11413 |
auxpass |
is,established |
R8997 |
T11412 |
T11413 |
advmod |
well,established |
R8998 |
T11413 |
T11413 |
ROOT |
established,established |
R8999 |
T11426 |
T11425 |
prep |
of,range |
R9000 |
T11414 |
T11422 |
mark |
that,overexpressed |
R9001 |
T11415 |
T11416 |
amod |
various,members |
R9002 |
T11427 |
T11428 |
amod |
human,tumours |
R9003 |
T11428 |
T11426 |
pobj |
tumours,of |
R9004 |
T11429 |
T11428 |
cc |
and,tumours |
R9005 |
T11439 |
T11440 |
advmod |
most,widely |
R9006 |
T11430 |
T11433 |
advmod |
generally,appears |
R9007 |
T11440 |
T11441 |
advmod |
widely,overexpressed |
R9008 |
T11441 |
T11435 |
attr |
overexpressed,be |
R9009 |
T11442 |
T11441 |
prep |
in,overexpressed |
R9010 |
T11443 |
T11444 |
det |
a,variety |
R9011 |
T11431 |
T11433 |
punct |
",",appears |
R9012 |
T11444 |
T11442 |
pobj |
variety,in |
R9013 |
T11432 |
T11433 |
nsubj |
Id1,appears |
R9014 |
T11433 |
T11413 |
conj |
appears,established |
R9015 |
T11445 |
T11444 |
prep |
of,variety |
R9016 |
T11434 |
T11435 |
aux |
to,be |
R9017 |
T11446 |
T11447 |
amod |
human,malignancies |
R9018 |
T11447 |
T11445 |
pobj |
malignancies,of |
R9019 |
T11448 |
T11450 |
nmod |
[,] |
R9020 |
T11449 |
T11450 |
nummod |
41,] |
R9021 |
T11450 |
T11444 |
appos |
],variety |
R9022 |
T11435 |
T11433 |
xcomp |
be,appears |
R9023 |
T11451 |
T11444 |
punct |
",",variety |
R9024 |
T11452 |
T11444 |
prep |
including,variety |
R9025 |
T11453 |
T11455 |
amod |
multiple,[ |
R9026 |
T11436 |
T11438 |
det |
the,member |
R9027 |
T11454 |
T11455 |
compound |
myeloma,[ |
R9028 |
T11455 |
T11452 |
pobj |
[,including |
R9029 |
T11437 |
T11438 |
compound |
family,member |
R9030 |
T11438 |
T11441 |
nsubj |
member,overexpressed |
R9031 |
T11456 |
T11457 |
nummod |
"42,32",] |
R9032 |
T11514 |
T11513 |
pobj |
Id1,of |
R9033 |
T11457 |
T11455 |
acl |
],[ |
R9034 |
T11458 |
T11433 |
punct |
.,appears |
R9035 |
T11459 |
T11474 |
advmod |
Additionally,be |
R9036 |
T11460 |
T11474 |
punct |
",",be |
R9037 |
T11515 |
T11512 |
prep |
to,expression |
R9038 |
T11461 |
T11462 |
poss |
our,findings |
R9039 |
T11462 |
T11474 |
nsubj |
findings,be |
R9040 |
T11516 |
T11515 |
pobj |
B-lymphocytes,to |
R9041 |
T11463 |
T11465 |
dobj |
that,activates |
R9042 |
T11464 |
T11465 |
nsubj |
BMP-6,activates |
R9043 |
T11517 |
T11507 |
ccomp |
resulted,is |
R9044 |
T11465 |
T11462 |
relcl |
activates,findings |
R9045 |
T11466 |
T11468 |
amod |
intracellular,pathways |
R9046 |
T11467 |
T11468 |
amod |
signalling,pathways |
R9047 |
T11518 |
T11517 |
prep |
in,resulted |
R9048 |
T11468 |
T11465 |
dobj |
pathways,activates |
R9049 |
T11469 |
T11468 |
prep |
in,pathways |
R9050 |
T11470 |
T11472 |
amod |
human,cells |
R9051 |
T11519 |
T11522 |
amod |
aberrant,development |
R9052 |
T11471 |
T11472 |
compound |
B,cells |
R9053 |
T11472 |
T11469 |
pobj |
cells,in |
R9054 |
T11473 |
T11474 |
aux |
might,be |
R9055 |
T11520 |
T11521 |
compound |
B,cell |
R9056 |
T11474 |
T11474 |
ROOT |
be,be |
R9057 |
T11475 |
T11474 |
prep |
of,be |
R9058 |
T11476 |
T11478 |
amod |
potential,significance |
R9059 |
T11521 |
T11522 |
compound |
cell,development |
R9060 |
T11477 |
T11478 |
amod |
pathophysiological,significance |
R9061 |
T11478 |
T11475 |
pobj |
significance,of |
R9062 |
T11479 |
T11478 |
prep |
in,significance |
R9063 |
T11522 |
T11518 |
pobj |
development,in |
R9064 |
T11480 |
T11479 |
pobj |
lymphoma,in |
R9065 |
T11481 |
T11480 |
cc |
and,lymphoma |
R9066 |
T11523 |
T11522 |
punct |
",",development |
R9067 |
T11482 |
T11480 |
conj |
inflammation,lymphoma |
R9068 |
T11483 |
T11474 |
punct |
.,be |
R9069 |
T11484 |
T11486 |
compound |
High,mRNA |
R9070 |
T11485 |
T11486 |
compound |
BMP-6,mRNA |
R9071 |
T11486 |
T11487 |
compound |
mRNA,expression |
R9072 |
T11487 |
T11492 |
nsubjpass |
expression,shown |
R9073 |
T11524 |
T11525 |
amod |
massive,apoptosis |
R9074 |
T11488 |
T11487 |
prep |
in,expression |
R9075 |
T11489 |
T11488 |
pobj |
DLBCL,in |
R9076 |
T11490 |
T11492 |
aux |
has,shown |
R9077 |
T11491 |
T11492 |
auxpass |
been,shown |
R9078 |
T11525 |
T11522 |
conj |
apoptosis,development |
R9079 |
T11492 |
T11492 |
ROOT |
shown,shown |
R9080 |
T11493 |
T11494 |
aux |
to,correlate |
R9081 |
T11494 |
T11492 |
xcomp |
correlate,shown |
R9082 |
T11526 |
T11517 |
punct |
",",resulted |
R9083 |
T11495 |
T11494 |
prep |
to,correlate |
R9084 |
T11496 |
T11497 |
amod |
unfavourable,outcome |
R9085 |
T11497 |
T11495 |
pobj |
outcome,to |
R9086 |
T11527 |
T11517 |
cc |
and,resulted |
R9087 |
T11498 |
T11500 |
nmod |
[,] |
R9088 |
T11499 |
T11500 |
nummod |
12,] |
R9089 |
T11500 |
T11495 |
pobj |
],to |
R9090 |
T11528 |
T11529 |
amod |
subsequent,development |
R9091 |
T11501 |
T11492 |
punct |
.,shown |
R9092 |
T11502 |
T11507 |
prep |
In,is |
R9093 |
T11503 |
T11504 |
det |
this,respect |
R9094 |
T11529 |
T11536 |
nmod |
development,] |
R9095 |
T11504 |
T11502 |
pobj |
respect,In |
R9096 |
T11505 |
T11507 |
punct |
",",is |
R9097 |
T11506 |
T11507 |
nsubj |
it,is |
R9098 |
T11530 |
T11529 |
prep |
of,development |
R9099 |
T11507 |
T11507 |
ROOT |
is,is |
R9100 |
T11508 |
T11507 |
prep |
of,is |
R9101 |
T11509 |
T11508 |
pobj |
interest,of |
R9102 |
T11531 |
T11532 |
compound |
B,cell |
R9103 |
T11510 |
T11517 |
dobj |
that,resulted |
R9104 |
T11511 |
T11512 |
amod |
targeted,expression |
R9105 |
T11512 |
T11517 |
nsubj |
expression,resulted |
R9106 |
T11532 |
T11533 |
compound |
cell,lymphomas |
R9107 |
T11513 |
T11512 |
prep |
of,expression |
R9108 |
T11533 |
T11530 |
pobj |
lymphomas,of |
R9109 |
T11534 |
T11536 |
nmod |
[,] |
R9110 |
T11613 |
T11609 |
xcomp |
elucidate,be |
R9111 |
T11535 |
T11536 |
nummod |
35,] |
R9112 |
T11536 |
T11507 |
npadvmod |
],is |
R9113 |
T11614 |
T11615 |
det |
the,role |
R9114 |
T11537 |
T11507 |
punct |
.,is |
R9115 |
T11538 |
T11543 |
advmod |
Moreover,suggested |
R9116 |
T11539 |
T11543 |
punct |
",",suggested |
R9117 |
T11540 |
T11543 |
nsubjpass |
BMP-6,suggested |
R9118 |
T11541 |
T11543 |
aux |
has,suggested |
R9119 |
T11542 |
T11543 |
auxpass |
been,suggested |
R9120 |
T11615 |
T11613 |
dobj |
role,elucidate |
R9121 |
T11543 |
T11543 |
ROOT |
suggested,suggested |
R9122 |
T11616 |
T11615 |
prep |
of,role |
R9123 |
T11617 |
T11616 |
pobj |
Id-1,of |
R9124 |
T11618 |
T11617 |
prep |
in,Id-1 |
R9125 |
T11544 |
T11545 |
aux |
to,play |
R9126 |
T11619 |
T11621 |
amod |
human,cells |
R9127 |
T11545 |
T11543 |
xcomp |
play,suggested |
R9128 |
T11620 |
T11621 |
compound |
B,cells |
R9129 |
T11546 |
T11547 |
det |
a,role |
R9130 |
T11547 |
T11545 |
dobj |
role,play |
R9131 |
T11621 |
T11618 |
pobj |
cells,in |
R9132 |
T11548 |
T11547 |
prep |
in,role |
R9133 |
T11549 |
T11550 |
amod |
rheumatoid,arthritis |
R9134 |
T11550 |
T11548 |
pobj |
arthritis,in |
R9135 |
T11622 |
T11613 |
prep |
by,elucidate |
R9136 |
T11551 |
T11552 |
punct |
(,RA |
R9137 |
T11552 |
T11550 |
appos |
RA,arthritis |
R9138 |
T11623 |
T11622 |
pobj |
selective,by |
R9139 |
T11553 |
T11543 |
punct |
),suggested |
R9140 |
T11554 |
T11556 |
compound |
[,] |
R9141 |
T11555 |
T11556 |
compound |
"43,44",] |
R9142 |
T11556 |
T11566 |
nsubjpass |
],found |
R9143 |
T11624 |
T11623 |
prt |
over,selective |
R9144 |
T11557 |
T11556 |
cc |
and,] |
R9145 |
T11558 |
T11559 |
amod |
elevated,levels |
R9146 |
T11559 |
T11556 |
conj |
levels,] |
R9147 |
T11625 |
T11624 |
pobj |
expression,over |
R9148 |
T11560 |
T11559 |
prep |
of,levels |
R9149 |
T11561 |
T11560 |
pobj |
Id1,of |
R9150 |
T11562 |
T11561 |
cc |
and,Id1 |
R9151 |
T11626 |
T11625 |
cc |
or,expression |
R9152 |
T11563 |
T11561 |
conj |
Id3,Id1 |
R9153 |
T11564 |
T11566 |
aux |
have,found |
R9154 |
T11627 |
T11625 |
conj |
inhibition,expression |
R9155 |
T11565 |
T11566 |
auxpass |
been,found |
R9156 |
T11566 |
T11566 |
ROOT |
found,found |
R9157 |
T11567 |
T11566 |
prep |
in,found |
R9158 |
T11628 |
T11625 |
prep |
of,expression |
R9159 |
T11568 |
T11569 |
det |
the,synovia |
R9160 |
T11569 |
T11567 |
pobj |
synovia,in |
R9161 |
T11570 |
T11569 |
prep |
of,synovia |
R9162 |
T11629 |
T11631 |
amod |
Id-1,expression |
R9163 |
T11571 |
T11570 |
pobj |
RA-patients,of |
R9164 |
T11572 |
T11574 |
quantmod |
[,] |
R9165 |
T11573 |
T11574 |
nummod |
45,] |
R9166 |
T11630 |
T11631 |
compound |
gene,expression |
R9167 |
T11574 |
T11569 |
appos |
],synovia |
R9168 |
T11575 |
T11566 |
punct |
.,found |
R9169 |
T11576 |
T11580 |
advmod |
Altogether,point |
R9170 |
T11577 |
T11580 |
punct |
",",point |
R9171 |
T11578 |
T11579 |
det |
these,results |
R9172 |
T11579 |
T11580 |
nsubj |
results,point |
R9173 |
T11631 |
T11628 |
pobj |
expression,of |
R9174 |
T11580 |
T11580 |
ROOT |
point,point |
R9175 |
T11581 |
T11580 |
prep |
to,point |
R9176 |
T11582 |
T11584 |
det |
an,role |
R9177 |
T11583 |
T11584 |
amod |
important,role |
R9178 |
T11632 |
T11609 |
punct |
.,be |
R9179 |
T11584 |
T11581 |
pobj |
role,to |
R9180 |
T11585 |
T11584 |
prep |
for,role |
R9181 |
T11633 |
T11643 |
prep |
Given,demonstrated |
R9182 |
T11586 |
T11587 |
compound |
Id,proteins |
R9183 |
T11587 |
T11585 |
pobj |
proteins,for |
R9184 |
T11588 |
T11584 |
prep |
in,role |
R9185 |
T11589 |
T11590 |
det |
the,regulation |
R9186 |
T11634 |
T11635 |
det |
the,role |
R9187 |
T11590 |
T11588 |
pobj |
regulation,in |
R9188 |
T11591 |
T11590 |
prep |
of,regulation |
R9189 |
T11592 |
T11595 |
amod |
normal,homeostasis |
R9190 |
T11635 |
T11633 |
pobj |
role,Given |
R9191 |
T11593 |
T11594 |
compound |
B,cell |
R9192 |
T11594 |
T11595 |
compound |
cell,homeostasis |
R9193 |
T11595 |
T11591 |
pobj |
homeostasis,of |
R9194 |
T11596 |
T11588 |
cc |
and,in |
R9195 |
T11636 |
T11635 |
prep |
of,role |
R9196 |
T11597 |
T11588 |
conj |
in,in |
R9197 |
T11598 |
T11597 |
pobj |
diseases,in |
R9198 |
T11637 |
T11636 |
pobj |
BMP-6,of |
R9199 |
T11599 |
T11598 |
punct |
",",diseases |
R9200 |
T11600 |
T11604 |
advmod |
where,involved |
R9201 |
T11601 |
T11602 |
compound |
B,cells |
R9202 |
T11602 |
T11604 |
nsubjpass |
cells,involved |
R9203 |
T11638 |
T11635 |
prep |
in,role |
R9204 |
T11603 |
T11604 |
auxpass |
are,involved |
R9205 |
T11604 |
T11598 |
relcl |
involved,diseases |
R9206 |
T11605 |
T11580 |
punct |
.,point |
R9207 |
T11606 |
T11609 |
nsubj |
It,be |
R9208 |
T11607 |
T11609 |
aux |
will,be |
R9209 |
T11639 |
T11642 |
amod |
mature,cells |
R9210 |
T11608 |
T11609 |
advmod |
therefore,be |
R9211 |
T11640 |
T11642 |
amod |
human,cells |
R9212 |
T11609 |
T11609 |
ROOT |
be,be |
R9213 |
T11610 |
T11609 |
acomp |
important,be |
R9214 |
T11641 |
T11642 |
compound |
B,cells |
R9215 |
T11611 |
T11613 |
aux |
to,elucidate |
R9216 |
T11612 |
T11613 |
advmod |
further,elucidate |
R9217 |
T11642 |
T11638 |
pobj |
cells,in |
R9218 |
T11643 |
T11643 |
ROOT |
demonstrated,demonstrated |
R9219 |
T11644 |
T11643 |
advmod |
here,demonstrated |
R9220 |
T11645 |
T11643 |
punct |
",",demonstrated |
R9221 |
T11646 |
T11664 |
nsubj |
identification,contribute |
R9222 |
T11711 |
T11718 |
punct |
",",reported |
R9223 |
T11647 |
T11646 |
prep |
of,identification |
R9224 |
T11712 |
T11715 |
det |
an,loop |
R9225 |
T11713 |
T11715 |
amod |
autocrine,loop |
R9226 |
T11648 |
T11649 |
nsubj |
BMP-6,producing |
R9227 |
T11714 |
T11715 |
compound |
BMP-6,loop |
R9228 |
T11715 |
T11718 |
nsubjpass |
loop,reported |
R9229 |
T11649 |
T11647 |
pcomp |
producing,of |
R9230 |
T11716 |
T11718 |
aux |
has,reported |
R9231 |
T11717 |
T11718 |
auxpass |
been,reported |
R9232 |
T11718 |
T11718 |
ROOT |
reported,reported |
R9233 |
T11650 |
T11649 |
dobj |
cells,producing |
R9234 |
T11719 |
T11718 |
agent |
by,reported |
R9235 |
T11720 |
T11719 |
pobj |
others,by |
R9236 |
T11721 |
T11720 |
prep |
in,others |
R9237 |
T11651 |
T11649 |
prep |
in,producing |
R9238 |
T11722 |
T11721 |
pobj |
chondrocytes,in |
R9239 |
T11723 |
T11721 |
cc |
and,in |
R9240 |
T11652 |
T11651 |
pobj |
vivo,in |
R9241 |
T11724 |
T11721 |
conj |
in,in |
R9242 |
T11725 |
T11726 |
det |
the,ovarium |
R9243 |
T11726 |
T11724 |
pobj |
ovarium,in |
R9244 |
T11653 |
T11649 |
prep |
with,producing |
R9245 |
T11654 |
T11653 |
pobj |
possibility,with |
R9246 |
T11655 |
T11654 |
prep |
of,possibility |
R9247 |
T11727 |
T11729 |
compound |
[,] |
R9248 |
T11656 |
T11655 |
pobj |
interaction,of |
R9249 |
T11728 |
T11729 |
compound |
"46,19,18",] |
R9250 |
T11729 |
T11720 |
appos |
],others |
R9251 |
T11657 |
T11656 |
prep |
with,interaction |
R9252 |
T11730 |
T11718 |
punct |
.,reported |
R9253 |
T11731 |
T11734 |
advmod |
Therefore,wanted |
R9254 |
T11658 |
T11657 |
pobj |
naïve,with |
R9255 |
T11732 |
T11734 |
punct |
",",wanted |
R9256 |
T11733 |
T11734 |
nsubj |
we,wanted |
R9257 |
T11659 |
T11658 |
cc |
and,naïve |
R9258 |
T11734 |
T11734 |
ROOT |
wanted,wanted |
R9259 |
T11735 |
T11736 |
aux |
to,explore |
R9260 |
T11736 |
T11734 |
xcomp |
explore,wanted |
R9261 |
T11660 |
T11662 |
compound |
memory,cells |
R9262 |
T11737 |
T11738 |
det |
the,possibility |
R9263 |
T11738 |
T11736 |
dobj |
possibility,explore |
R9264 |
T11739 |
T11738 |
prep |
for,possibility |
R9265 |
T11661 |
T11662 |
compound |
B,cells |
R9266 |
T11740 |
T11743 |
det |
an,loop |
R9267 |
T11741 |
T11743 |
amod |
autocrine,loop |
R9268 |
T11742 |
T11743 |
compound |
BMP-6,loop |
R9269 |
T11743 |
T11739 |
pobj |
loop,for |
R9270 |
T11744 |
T11743 |
prep |
in,loop |
R9271 |
T11745 |
T11747 |
amod |
human,cells |
R9272 |
T11662 |
T11658 |
conj |
cells,naïve |
R9273 |
T11746 |
T11747 |
compound |
B,cells |
R9274 |
T11747 |
T11744 |
pobj |
cells,in |
R9275 |
T11748 |
T11734 |
punct |
.,wanted |
R9276 |
T11749 |
T11750 |
nsubj |
We,analysed |
R9277 |
T11663 |
T11664 |
aux |
might,contribute |
R9278 |
T11750 |
T11750 |
ROOT |
analysed,analysed |
R9279 |
T11751 |
T11752 |
det |
the,expression |
R9280 |
T11752 |
T11750 |
dobj |
expression,analysed |
R9281 |
T11664 |
T11643 |
ccomp |
contribute,demonstrated |
R9282 |
T11753 |
T11754 |
compound |
BMP-6,mRNA |
R9283 |
T11754 |
T11752 |
appos |
mRNA,expression |
R9284 |
T11755 |
T11750 |
prep |
in,analysed |
R9285 |
T11665 |
T11664 |
prep |
to,contribute |
R9286 |
T11756 |
T11759 |
amod |
peripheral,cells |
R9287 |
T11757 |
T11758 |
compound |
blood,B |
R9288 |
T11758 |
T11759 |
compound |
B,cells |
R9289 |
T11666 |
T11667 |
det |
the,understanding |
R9290 |
T11759 |
T11755 |
pobj |
cells,in |
R9291 |
T11760 |
T11750 |
prep |
by,analysed |
R9292 |
T11761 |
T11762 |
amod |
real-time,PCR |
R9293 |
T11762 |
T11760 |
pobj |
PCR,by |
R9294 |
T11667 |
T11665 |
pobj |
understanding,to |
R9295 |
T11763 |
T11750 |
punct |
",",analysed |
R9296 |
T11764 |
T11750 |
cc |
and,analysed |
R9297 |
T11668 |
T11667 |
prep |
of,understanding |
R9298 |
T11765 |
T11750 |
conj |
report,analysed |
R9299 |
T11669 |
T11672 |
amod |
mature,biology |
R9300 |
T11766 |
T11765 |
advmod |
here,report |
R9301 |
T11670 |
T11671 |
compound |
B,cell |
R9302 |
T11767 |
T11768 |
det |
the,upregulation |
R9303 |
T11768 |
T11765 |
dobj |
upregulation,report |
R9304 |
T11769 |
T11768 |
prep |
of,upregulation |
R9305 |
T11671 |
T11672 |
compound |
cell,biology |
R9306 |
T11770 |
T11772 |
amod |
endogenous,transcripts |
R9307 |
T11771 |
T11772 |
compound |
BMP-6,transcripts |
R9308 |
T11772 |
T11769 |
pobj |
transcripts,of |
R9309 |
T11672 |
T11668 |
pobj |
biology,of |
R9310 |
T11773 |
T11768 |
prep |
after,upregulation |
R9311 |
T11774 |
T11773 |
pobj |
stimulation,after |
R9312 |
T11775 |
T11768 |
prep |
with,upregulation |
R9313 |
T11673 |
T11643 |
punct |
.,demonstrated |
R9314 |
T11776 |
T11775 |
pobj |
FCS,with |
R9315 |
T11777 |
T11768 |
punct |
",",upregulation |
R9316 |
T11674 |
T11676 |
compound |
High,mRNA |
R9317 |
T11778 |
T11779 |
compound |
human,AB-serum |
R9318 |
T11779 |
T11768 |
conj |
AB-serum,upregulation |
R9319 |
T11780 |
T11779 |
cc |
and,AB-serum |
R9320 |
T11781 |
T11785 |
punct |
",",anti-IgM |
R9321 |
T11782 |
T11783 |
advmod |
most,importantly |
R9322 |
T11783 |
T11785 |
advmod |
importantly,anti-IgM |
R9323 |
T11675 |
T11676 |
compound |
BMP-6,mRNA |
R9324 |
T11784 |
T11785 |
punct |
",",anti-IgM |
R9325 |
T11785 |
T11779 |
conj |
anti-IgM,AB-serum |
R9326 |
T11786 |
T11785 |
punct |
.,anti-IgM |
R9327 |
T11676 |
T11677 |
compound |
mRNA,expression |
R9328 |
T11787 |
T11796 |
advmod |
However,were |
R9329 |
T11788 |
T11796 |
punct |
",",were |
R9330 |
T11789 |
T11790 |
poss |
our,attempts |
R9331 |
T11790 |
T11796 |
nsubj |
attempts,were |
R9332 |
T11677 |
T11682 |
nsubjpass |
expression,detected |
R9333 |
T11791 |
T11792 |
aux |
to,study |
R9334 |
T11792 |
T11790 |
acl |
study,attempts |
R9335 |
T11793 |
T11795 |
compound |
BMP-6,levels |
R9336 |
T11678 |
T11677 |
prep |
in,expression |
R9337 |
T11794 |
T11795 |
compound |
protein,levels |
R9338 |
T11795 |
T11792 |
dobj |
levels,study |
R9339 |
T11796 |
T11796 |
ROOT |
were,were |
R9340 |
T11679 |
T11678 |
pobj |
DLBCL,in |
R9341 |
T11797 |
T11796 |
acomp |
unsuccessful,were |
R9342 |
T11798 |
T11796 |
acomp |
due,were |
R9343 |
T11799 |
T11798 |
prep |
to,due |
R9344 |
T11680 |
T11682 |
aux |
has,detected |
R9345 |
T11800 |
T11799 |
pobj |
problems,to |
R9346 |
T11801 |
T11800 |
prep |
with,problems |
R9347 |
T11802 |
T11803 |
amod |
unspecific,binding |
R9348 |
T11803 |
T11801 |
pobj |
binding,with |
R9349 |
T11681 |
T11682 |
auxpass |
been,detected |
R9350 |
T11804 |
T11803 |
prep |
of,binding |
R9351 |
T11805 |
T11807 |
det |
the,antibodies |
R9352 |
T11806 |
T11807 |
amod |
anti-BMP-6,antibodies |
R9353 |
T11682 |
T11682 |
ROOT |
detected,detected |
R9354 |
T11807 |
T11804 |
pobj |
antibodies,of |
R9355 |
T11808 |
T11803 |
conj |
tested,binding |
R9356 |
T11809 |
T11808 |
punct |
",",tested |
R9357 |
T11683 |
T11682 |
agent |
by,detected |
R9358 |
T11684 |
T11685 |
compound |
gene,expression |
R9359 |
T11685 |
T11683 |
pobj |
expression,by |
R9360 |
T11810 |
T11808 |
cc |
and,tested |
R9361 |
T11811 |
T11801 |
pobj |
lack,with |
R9362 |
T11686 |
T11685 |
acl |
profiling,expression |
R9363 |
T11812 |
T11811 |
prep |
of,lack |
R9364 |
T11813 |
T11814 |
amod |
specific,staining |
R9365 |
T11687 |
T11689 |
nmod |
[,] |
R9366 |
T11814 |
T11812 |
pobj |
staining,of |
R9367 |
T11815 |
T11814 |
prep |
in,staining |
R9368 |
T11816 |
T11817 |
compound |
control,cells |
R9369 |
T11817 |
T11815 |
pobj |
cells,in |
R9370 |
T11818 |
T11817 |
acl |
known,cells |
R9371 |
T11688 |
T11689 |
nummod |
12,] |
R9372 |
T11819 |
T11820 |
aux |
to,express |
R9373 |
T11820 |
T11818 |
xcomp |
express,known |
R9374 |
T11821 |
T11822 |
compound |
BMP-6,mRNA |
R9375 |
T11689 |
T11686 |
dobj |
],profiling |
R9376 |
T11822 |
T11820 |
dobj |
mRNA,express |
R9377 |
T11823 |
T11796 |
punct |
.,were |
R9378 |
T11690 |
T11682 |
punct |
.,detected |
R9379 |
T11824 |
T11832 |
prep |
In,detected |
R9380 |
T11825 |
T11824 |
pobj |
contrast,In |
R9381 |
T11826 |
T11832 |
punct |
",",detected |
R9382 |
T11691 |
T11703 |
advmod |
Furthermore,detected |
R9383 |
T11827 |
T11829 |
det |
the,protein |
R9384 |
T11828 |
T11829 |
compound |
recombinant,protein |
R9385 |
T11692 |
T11703 |
punct |
",",detected |
R9386 |
T11829 |
T11832 |
nsubjpass |
protein,detected |
R9387 |
T11830 |
T11832 |
auxpass |
was,detected |
R9388 |
T11831 |
T11832 |
advmod |
readily,detected |
R9389 |
T11693 |
T11703 |
nsubjpass |
production,detected |
R9390 |
T11832 |
T11832 |
ROOT |
detected,detected |
R9391 |
T11833 |
T11832 |
punct |
.,detected |
R9392 |
T11834 |
T11841 |
prep |
In,detected |
R9393 |
T11694 |
T11693 |
prep |
of,production |
R9394 |
T11835 |
T11836 |
det |
that,respect |
R9395 |
T11836 |
T11834 |
pobj |
respect,In |
R9396 |
T11837 |
T11841 |
punct |
",",detected |
R9397 |
T11695 |
T11696 |
compound |
BMP-6,transcripts |
R9398 |
T11838 |
T11839 |
amod |
few,investigators |
R9399 |
T11839 |
T11841 |
nsubj |
investigators,detected |
R9400 |
T11840 |
T11841 |
aux |
have,detected |
R9401 |
T11696 |
T11694 |
pobj |
transcripts,of |
R9402 |
T11841 |
T11841 |
ROOT |
detected,detected |
R9403 |
T11842 |
T11843 |
compound |
BMP-6,protein |
R9404 |
T11843 |
T11841 |
dobj |
protein,detected |
R9405 |
T11697 |
T11693 |
prep |
in,production |
R9406 |
T11844 |
T11843 |
prep |
in,protein |
R9407 |
T11698 |
T11701 |
amod |
normal,cells |
R9408 |
T11699 |
T11701 |
amod |
activated,cells |
R9409 |
T11845 |
T11844 |
pobj |
humans,in |
R9410 |
T11846 |
T11844 |
punct |
",",in |
R9411 |
T11700 |
T11701 |
compound |
B,cells |
R9412 |
T11847 |
T11848 |
advmod |
especially,in |
R9413 |
T11848 |
T11844 |
conj |
in,in |
R9414 |
T11849 |
T11850 |
amod |
non-pathogenic,tissue |
R9415 |
T11701 |
T11697 |
pobj |
cells,in |
R9416 |
T11850 |
T11848 |
pobj |
tissue,in |
R9417 |
T11851 |
T11841 |
punct |
.,detected |
R9418 |
T11852 |
T11853 |
det |
The,possibility |
R9419 |
T11853 |
T11860 |
nsubj |
possibility,is |
R9420 |
T11854 |
T11853 |
prep |
of,possibility |
R9421 |
T11702 |
T11703 |
auxpass |
was,detected |
R9422 |
T11855 |
T11856 |
compound |
BMP-6,production |
R9423 |
T11856 |
T11854 |
pobj |
production,of |
R9424 |
T11703 |
T11703 |
ROOT |
detected,detected |
R9425 |
T11857 |
T11856 |
prep |
in,production |
R9426 |
T11858 |
T11859 |
amod |
human,B-cells |
R9427 |
T11859 |
T11857 |
pobj |
B-cells,in |
R9428 |
T11860 |
T11860 |
ROOT |
is,is |
R9429 |
T11704 |
T11703 |
prep |
in,detected |
R9430 |
T11861 |
T11860 |
prep |
in,is |
R9431 |
T11862 |
T11861 |
pobj |
line,in |
R9432 |
T11705 |
T11707 |
det |
the,study |
R9433 |
T11863 |
T11862 |
prep |
with,line |
R9434 |
T11864 |
T11866 |
det |
a,work |
R9435 |
T11865 |
T11866 |
amod |
recent,work |
R9436 |
T11866 |
T11863 |
pobj |
work,with |
R9437 |
T11706 |
T11707 |
amod |
same,study |
R9438 |
T11867 |
T11868 |
nsubj |
that,reported |
R9439 |
T11868 |
T11866 |
relcl |
reported,work |
R9440 |
T11707 |
T11704 |
pobj |
study,in |
R9441 |
T11869 |
T11870 |
det |
the,production |
R9442 |
T11870 |
T11868 |
dobj |
production,reported |
R9443 |
T11871 |
T11870 |
prep |
of,production |
R9444 |
T11872 |
T11871 |
pobj |
BMP-6,of |
R9445 |
T11708 |
T11703 |
punct |
.,detected |
R9446 |
T11873 |
T11870 |
prep |
in,production |
R9447 |
T11874 |
T11876 |
compound |
mouse,cells |
R9448 |
T11709 |
T11718 |
prep |
Of,reported |
R9449 |
T11875 |
T11876 |
compound |
B,cells |
R9450 |
T11876 |
T11873 |
pobj |
cells,in |
R9451 |
T11877 |
T11860 |
punct |
",",is |
R9452 |
T11878 |
T11860 |
advcl |
infiltrating,is |
R9453 |
T11710 |
T11709 |
pobj |
note,Of |
R9454 |
T11879 |
T11881 |
det |
the,marrow |
R9455 |
T11880 |
T11881 |
compound |
bone,marrow |
R9456 |
T11881 |
T11878 |
dobj |
marrow,infiltrating |
R9457 |
T11907 |
T11906 |
punct |
.,suggested |
R9458 |
T11882 |
T11881 |
prep |
of,marrow |
R9459 |
T11883 |
T11882 |
pobj |
mice,of |
R9460 |
T11884 |
T11881 |
prep |
with,marrow |
R9461 |
T11885 |
T11886 |
amod |
inflammatory,arthritis |
R9462 |
T11886 |
T11884 |
pobj |
arthritis,with |
R9463 |
T11908 |
T11909 |
det |
The,upregulation |
R9464 |
T11887 |
T11889 |
nmod |
[,] |
R9465 |
T11888 |
T11889 |
nummod |
43,] |
R9466 |
T11909 |
T11915 |
nsubj |
upregulation,is |
R9467 |
T11889 |
T11881 |
appos |
],marrow |
R9468 |
T11890 |
T11860 |
punct |
.,is |
R9469 |
T11891 |
T11906 |
prep |
In,suggested |
R9470 |
T11892 |
T11893 |
det |
this,study |
R9471 |
T11893 |
T11891 |
pobj |
study,In |
R9472 |
T11894 |
T11906 |
punct |
",",suggested |
R9473 |
T11910 |
T11909 |
prep |
of,upregulation |
R9474 |
T11895 |
T11896 |
det |
a,role |
R9475 |
T11896 |
T11906 |
nsubjpass |
role,suggested |
R9476 |
T11897 |
T11896 |
prep |
for,role |
R9477 |
T11911 |
T11912 |
det |
the,BMP-6-transcripts |
R9478 |
T11898 |
T11897 |
pobj |
BMPs,for |
R9479 |
T11899 |
T11898 |
prep |
in,BMPs |
R9480 |
T11900 |
T11902 |
det |
the,process |
R9481 |
T11912 |
T11910 |
pobj |
BMP-6-transcripts,of |
R9482 |
T11901 |
T11902 |
amod |
inflammatoric,process |
R9483 |
T11902 |
T11899 |
pobj |
process,in |
R9484 |
T11903 |
T11902 |
prep |
of,process |
R9485 |
T11913 |
T11909 |
prep |
after,upregulation |
R9486 |
T11904 |
T11903 |
pobj |
arthritis,of |
R9487 |
T11905 |
T11906 |
auxpass |
was,suggested |
R9488 |
T11906 |
T11906 |
ROOT |
suggested,suggested |
R9489 |
T11914 |
T11915 |
nsubj |
IgM-crosslinking,is |
R9490 |
T11915 |
T11915 |
ROOT |
is,is |
R9491 |
T11916 |
T11915 |
prep |
of,is |
R9492 |
T11917 |
T11918 |
amod |
pathophysiologic,interest |
R9493 |
T11918 |
T11916 |
pobj |
interest,of |
R9494 |
T12004 |
T12013 |
mark |
that,define |
R9495 |
T11919 |
T11921 |
nmod |
[,] |
R9496 |
T12005 |
T12006 |
amod |
cellular,context |
R9497 |
T12006 |
T12013 |
nsubj |
context,define |
R9498 |
T11920 |
T11921 |
nummod |
12,] |
R9499 |
T11921 |
T11915 |
attr |
],is |
R9500 |
T12007 |
T12006 |
prep |
of,context |
R9501 |
T11922 |
T11915 |
punct |
.,is |
R9502 |
T12008 |
T12011 |
det |
the,cell |
R9503 |
T12009 |
T12011 |
compound |
BMP,cell |
R9504 |
T11923 |
T11924 |
det |
A,loss |
R9505 |
T12010 |
T12011 |
compound |
target,cell |
R9506 |
T12011 |
T12007 |
pobj |
cell,of |
R9507 |
T12012 |
T12013 |
aux |
might,define |
R9508 |
T11924 |
T11929 |
nsubjpass |
loss,suggested |
R9509 |
T12013 |
T12003 |
ccomp |
define,indicating |
R9510 |
T12014 |
T12017 |
det |
the,effects |
R9511 |
T11925 |
T11924 |
prep |
of,loss |
R9512 |
T11926 |
T11925 |
pobj |
TGF-β-responsiveness,of |
R9513 |
T12015 |
T12017 |
amod |
various,effects |
R9514 |
T12016 |
T12017 |
amod |
observed,effects |
R9515 |
T12017 |
T12013 |
dobj |
effects,define |
R9516 |
T11927 |
T11929 |
aux |
has,suggested |
R9517 |
T12018 |
T11982 |
punct |
.,are |
R9518 |
T12019 |
T12032 |
prep |
In,were |
R9519 |
T12020 |
T12019 |
pobj |
contrast,In |
R9520 |
T12021 |
T12020 |
prep |
to,contrast |
R9521 |
T12022 |
T12023 |
det |
the,upregulation |
R9522 |
T11928 |
T11929 |
auxpass |
been,suggested |
R9523 |
T12023 |
T12021 |
pobj |
upregulation,to |
R9524 |
T12024 |
T12023 |
prep |
of,upregulation |
R9525 |
T12025 |
T12026 |
compound |
BMP-6,transcript |
R9526 |
T12026 |
T12024 |
pobj |
transcript,of |
R9527 |
T12027 |
T12023 |
prep |
in,upregulation |
R9528 |
T12028 |
T12029 |
compound |
B,cells |
R9529 |
T11929 |
T11929 |
ROOT |
suggested,suggested |
R9530 |
T12029 |
T12027 |
pobj |
cells,in |
R9531 |
T12030 |
T12032 |
punct |
",",were |
R9532 |
T12031 |
T12032 |
nsubj |
we,were |
R9533 |
T11930 |
T11931 |
aux |
to,be |
R9534 |
T12032 |
T12032 |
ROOT |
were,were |
R9535 |
T12033 |
T12032 |
neg |
not,were |
R9536 |
T12034 |
T12032 |
acomp |
able,were |
R9537 |
T11931 |
T11929 |
xcomp |
be,suggested |
R9538 |
T12035 |
T12036 |
aux |
to,detect |
R9539 |
T12036 |
T12034 |
xcomp |
detect,able |
R9540 |
T11932 |
T11934 |
det |
a,contribution |
R9541 |
T12037 |
T12038 |
compound |
BMP-6,transcripts |
R9542 |
T12038 |
T12036 |
dobj |
transcripts,detect |
R9543 |
T12039 |
T12036 |
prep |
in,detect |
R9544 |
T11933 |
T11934 |
amod |
critical,contribution |
R9545 |
T12040 |
T12042 |
amod |
human,blood |
R9546 |
T12041 |
T12042 |
amod |
peripheral,blood |
R9547 |
T12042 |
T12043 |
compound |
blood,CD4 |
R9548 |
T12043 |
T12039 |
pobj |
CD4,in |
R9549 |
T11934 |
T11931 |
attr |
contribution,be |
R9550 |
T12044 |
T12043 |
nummod |
+,CD4 |
R9551 |
T12045 |
T12043 |
cc |
or,CD4 |
R9552 |
T12046 |
T12049 |
nummod |
CD8,cells |
R9553 |
T11935 |
T11934 |
prep |
to,contribution |
R9554 |
T12047 |
T12049 |
nummod |
+,cells |
R9555 |
T12048 |
T12049 |
compound |
T,cells |
R9556 |
T12049 |
T12043 |
conj |
cells,CD4 |
R9557 |
T11936 |
T11937 |
amod |
malignant,transformation |
R9558 |
T12050 |
T12051 |
punct |
(,resting |
R9559 |
T12051 |
T12043 |
acl |
resting,CD4 |
R9560 |
T11937 |
T11935 |
pobj |
transformation,to |
R9561 |
T12052 |
T12051 |
cc |
or,resting |
R9562 |
T12053 |
T12051 |
conj |
stimulated,resting |
R9563 |
T12054 |
T12053 |
prep |
with,stimulated |
R9564 |
T11938 |
T11940 |
nmod |
[,] |
R9565 |
T12055 |
T12059 |
amod |
anti-CD3,data |
R9566 |
T12056 |
T12055 |
cc |
and,anti-CD3 |
R9567 |
T12057 |
T12055 |
conj |
anti-CD28,anti-CD3 |
R9568 |
T12058 |
T12059 |
punct |
;,data |
R9569 |
T12059 |
T12054 |
pobj |
data,with |
R9570 |
T12060 |
T12061 |
neg |
not,shown |
R9571 |
T11939 |
T11940 |
nummod |
"47,48",] |
R9572 |
T12061 |
T12059 |
acl |
shown,data |
R9573 |
T12062 |
T12059 |
punct |
),data |
R9574 |
T12063 |
T12059 |
punct |
",",data |
R9575 |
T12064 |
T12059 |
amod |
consistent,data |
R9576 |
T11940 |
T11944 |
nmod |
],mechanisms |
R9577 |
T12065 |
T12064 |
prep |
with,consistent |
R9578 |
T12066 |
T12067 |
det |
the,findings |
R9579 |
T12067 |
T12065 |
pobj |
findings,with |
R9580 |
T11941 |
T11940 |
cc |
and,] |
R9581 |
T12068 |
T12067 |
prep |
in,findings |
R9582 |
T12069 |
T12070 |
compound |
T,cell |
R9583 |
T12070 |
T12071 |
compound |
cell,lines |
R9584 |
T11942 |
T11944 |
amod |
similar,mechanisms |
R9585 |
T12071 |
T12068 |
pobj |
lines,in |
R9586 |
T12072 |
T12074 |
nmod |
[,] |
R9587 |
T11943 |
T11944 |
amod |
oncogenic,mechanisms |
R9588 |
T12073 |
T12074 |
nummod |
20,] |
R9589 |
T12074 |
T12077 |
nmod |
],cells |
R9590 |
T12075 |
T12074 |
cc |
and,] |
R9591 |
T11944 |
T11947 |
nsubjpass |
mechanisms,postulated |
R9592 |
T12076 |
T12074 |
conj |
T,] |
R9593 |
T12077 |
T12067 |
conj |
cells,findings |
R9594 |
T12078 |
T12067 |
prep |
in,findings |
R9595 |
T11945 |
T11947 |
aux |
have,postulated |
R9596 |
T12079 |
T12078 |
pobj |
mice,in |
R9597 |
T12080 |
T12082 |
nmod |
[,] |
R9598 |
T12081 |
T12082 |
nummod |
43,] |
R9599 |
T11946 |
T11947 |
auxpass |
been,postulated |
R9600 |
T11947 |
T11929 |
conj |
postulated,suggested |
R9601 |
T12082 |
T12067 |
appos |
],findings |
R9602 |
T12083 |
T12032 |
punct |
.,were |
R9603 |
T11948 |
T11947 |
prep |
for,postulated |
R9604 |
T12084 |
T12087 |
amod |
Other,sources |
R9605 |
T12085 |
T12087 |
amod |
potential,sources |
R9606 |
T11949 |
T11948 |
pobj |
BMPs,for |
R9607 |
T11950 |
T11947 |
punct |
.,postulated |
R9608 |
T11951 |
T11954 |
nsubj |
Lines,suggest |
R9609 |
T12086 |
T12087 |
compound |
BMP-6,sources |
R9610 |
T12087 |
T12095 |
nsubj |
sources,be |
R9611 |
T11952 |
T11951 |
prep |
of,Lines |
R9612 |
T12088 |
T12087 |
prep |
for,sources |
R9613 |
T12089 |
T12091 |
amod |
mature,cells |
R9614 |
T12090 |
T12091 |
compound |
B,cells |
R9615 |
T11953 |
T11952 |
pobj |
evidence,of |
R9616 |
T12091 |
T12088 |
pobj |
cells,for |
R9617 |
T12092 |
T12091 |
prep |
in,cells |
R9618 |
T12093 |
T12092 |
pobj |
vivo,in |
R9619 |
T12094 |
T12095 |
aux |
might,be |
R9620 |
T12095 |
T12095 |
ROOT |
be,be |
R9621 |
T11954 |
T11954 |
ROOT |
suggest,suggest |
R9622 |
T12096 |
T12097 |
amod |
other,cells |
R9623 |
T12097 |
T12095 |
attr |
cells,be |
R9624 |
T11955 |
T11957 |
nsubj |
[,] |
R9625 |
T12098 |
T12097 |
prep |
of,cells |
R9626 |
T12099 |
T12101 |
det |
the,system |
R9627 |
T11956 |
T11957 |
nummod |
49,] |
R9628 |
T12100 |
T12101 |
amod |
immune,system |
R9629 |
T12101 |
T12098 |
pobj |
system,of |
R9630 |
T11957 |
T11954 |
dobj |
],suggest |
R9631 |
T11958 |
T11966 |
mark |
that,is |
R9632 |
T12102 |
T12101 |
cc |
or,system |
R9633 |
T12103 |
T12101 |
conj |
tissue,system |
R9634 |
T12104 |
T12103 |
prep |
with,tissue |
R9635 |
T11959 |
T11966 |
prep |
at,is |
R9636 |
T12105 |
T12104 |
pobj |
contact,with |
R9637 |
T12106 |
T12105 |
prep |
to,contact |
R9638 |
T11960 |
T11961 |
amod |
early,stages |
R9639 |
T12107 |
T12109 |
det |
the,system |
R9640 |
T12108 |
T12109 |
amod |
hematopoietic,system |
R9641 |
T11961 |
T11959 |
pobj |
stages,at |
R9642 |
T12109 |
T12106 |
pobj |
system,to |
R9643 |
T12110 |
T12095 |
punct |
.,be |
R9644 |
T11962 |
T11961 |
prep |
of,stages |
R9645 |
T11963 |
T11962 |
pobj |
carcinogenesis,of |
R9646 |
T11964 |
T11966 |
punct |
",",is |
R9647 |
T11965 |
T11966 |
nsubj |
BMP-6,is |
R9648 |
T12111 |
T12114 |
nummod |
One,source |
R9649 |
T12112 |
T12113 |
advmod |
well,recognized |
R9650 |
T12113 |
T12114 |
amod |
recognized,source |
R9651 |
T11966 |
T11957 |
relcl |
is,] |
R9652 |
T12114 |
T12118 |
nsubj |
source,is |
R9653 |
T12115 |
T12114 |
prep |
for,source |
R9654 |
T11967 |
T11966 |
neg |
not,is |
R9655 |
T12116 |
T12117 |
compound |
BMP-6,production |
R9656 |
T12117 |
T12115 |
pobj |
production,for |
R9657 |
T12118 |
T12118 |
ROOT |
is,is |
R9658 |
T11968 |
T11970 |
det |
a,promoter |
R9659 |
T12119 |
T12121 |
det |
the,bone |
R9660 |
T12120 |
T12121 |
amod |
human,bone |
R9661 |
T11969 |
T11970 |
compound |
tumour,promoter |
R9662 |
T12121 |
T12118 |
attr |
bone,is |
R9663 |
T12122 |
T12121 |
cc |
and,bone |
R9664 |
T12123 |
T12124 |
compound |
bone,marrow |
R9665 |
T11970 |
T11966 |
attr |
promoter,is |
R9666 |
T12124 |
T12125 |
compound |
marrow,stroma |
R9667 |
T12125 |
T12121 |
conj |
stroma,bone |
R9668 |
T12126 |
T12128 |
compound |
[,] |
R9669 |
T12127 |
T12128 |
compound |
"51,8",] |
R9670 |
T12128 |
T12121 |
appos |
],bone |
R9671 |
T11971 |
T11954 |
punct |
",",suggest |
R9672 |
T12129 |
T12118 |
punct |
.,is |
R9673 |
T12130 |
T12133 |
advmod |
Furthermore,is |
R9674 |
T12131 |
T12133 |
punct |
",",is |
R9675 |
T12132 |
T12133 |
nsubj |
it,is |
R9676 |
T11972 |
T11954 |
cc |
but,suggest |
R9677 |
T12133 |
T12133 |
ROOT |
is,is |
R9678 |
T12134 |
T12133 |
acomp |
noteworthy,is |
R9679 |
T11973 |
T11954 |
conj |
suppresses,suggest |
R9680 |
T12135 |
T12145 |
mark |
that,express |
R9681 |
T12136 |
T12138 |
amod |
human,vein |
R9682 |
T12137 |
T12138 |
amod |
umbilical,vein |
R9683 |
T11974 |
T11978 |
amod |
benign,outgrowth |
R9684 |
T12138 |
T12140 |
nmod |
vein,cells |
R9685 |
T12139 |
T12140 |
amod |
endothelial,cells |
R9686 |
T12140 |
T12145 |
nsubj |
cells,express |
R9687 |
T11975 |
T11974 |
cc |
and,benign |
R9688 |
T12141 |
T12140 |
punct |
(,cells |
R9689 |
T12142 |
T12140 |
appos |
HUVEC,cells |
R9690 |
T12143 |
T12140 |
punct |
),cells |
R9691 |
T11976 |
T11974 |
conj |
malignant,benign |
R9692 |
T12144 |
T12145 |
advmod |
highly,express |
R9693 |
T12145 |
T12133 |
ccomp |
express,is |
R9694 |
T12146 |
T12148 |
compound |
BMP-6,[ |
R9695 |
T11977 |
T11978 |
compound |
tumour,outgrowth |
R9696 |
T12147 |
T12148 |
compound |
mRNA,[ |
R9697 |
T12148 |
T12145 |
dobj |
[,express |
R9698 |
T11978 |
T11973 |
dobj |
outgrowth,suppresses |
R9699 |
T12149 |
T12150 |
nummod |
52,] |
R9700 |
T12150 |
T12148 |
conj |
],[ |
R9701 |
T12151 |
T12150 |
punct |
",",] |
R9702 |
T12152 |
T12150 |
cc |
and,] |
R9703 |
T11979 |
T11954 |
punct |
.,suggest |
R9704 |
T12153 |
T12154 |
amod |
vascular,endothelium |
R9705 |
T12154 |
T12150 |
conj |
endothelium,] |
R9706 |
T12155 |
T12157 |
aux |
has,reported |
R9707 |
T11980 |
T11981 |
det |
These,findings |
R9708 |
T12156 |
T12157 |
auxpass |
been,reported |
R9709 |
T12157 |
T12145 |
conj |
reported,express |
R9710 |
T11981 |
T11982 |
nsubj |
findings,are |
R9711 |
T12158 |
T12159 |
aux |
to,produce |
R9712 |
T12159 |
T12157 |
xcomp |
produce,reported |
R9713 |
T12160 |
T12161 |
compound |
BMP-6,[ |
R9714 |
T11982 |
T11982 |
ROOT |
are,are |
R9715 |
T12161 |
T12159 |
dobj |
[,produce |
R9716 |
T12162 |
T12163 |
nummod |
53,] |
R9717 |
T11983 |
T11982 |
prep |
in,are |
R9718 |
T11984 |
T11985 |
amod |
good,agreement |
R9719 |
T12163 |
T12161 |
appos |
],[ |
R9720 |
T11985 |
T11983 |
pobj |
agreement,in |
R9721 |
T12164 |
T12133 |
punct |
.,is |
R9722 |
T11986 |
T11985 |
prep |
with,agreement |
R9723 |
T12165 |
T12166 |
det |
These,studies |
R9724 |
T12166 |
T12168 |
nsubj |
studies,imply |
R9725 |
T12167 |
T12168 |
aux |
might,imply |
R9726 |
T11987 |
T11988 |
amod |
previous,findings |
R9727 |
T12168 |
T12168 |
ROOT |
imply,imply |
R9728 |
T12169 |
T12170 |
det |
a,role |
R9729 |
T12170 |
T12168 |
dobj |
role,imply |
R9730 |
T11988 |
T11986 |
pobj |
findings,with |
R9731 |
T12171 |
T12170 |
prep |
for,role |
R9732 |
T12172 |
T12171 |
pobj |
BMP-6,for |
R9733 |
T11989 |
T11985 |
prep |
for,agreement |
R9734 |
T12173 |
T12170 |
prep |
in,role |
R9735 |
T12174 |
T12175 |
amod |
transendothelial,migration |
R9736 |
T12175 |
T12173 |
pobj |
migration,in |
R9737 |
T11990 |
T11993 |
amod |
other,members |
R9738 |
T12176 |
T12175 |
prep |
of,migration |
R9739 |
T12177 |
T12178 |
compound |
B,cells |
R9740 |
T12178 |
T12176 |
pobj |
cells,of |
R9741 |
T11991 |
T11993 |
compound |
TGF-β,members |
R9742 |
T12179 |
T12168 |
punct |
.,imply |
R9743 |
T12180 |
T12184 |
npadvmod |
BMP-6,demonstrated |
R9744 |
T11992 |
T11993 |
compound |
family,members |
R9745 |
T12181 |
T12184 |
nsubjpass |
mRNA,demonstrated |
R9746 |
T12182 |
T12184 |
aux |
has,demonstrated |
R9747 |
T12183 |
T12184 |
auxpass |
been,demonstrated |
R9748 |
T12184 |
T12184 |
ROOT |
demonstrated,demonstrated |
R9749 |
T11993 |
T11989 |
pobj |
members,for |
R9750 |
T12185 |
T12184 |
prep |
in,demonstrated |
R9751 |
T12186 |
T12189 |
compound |
murine,lines |
R9752 |
T11994 |
T11993 |
punct |
",",members |
R9753 |
T12187 |
T12189 |
compound |
macrophage,lines |
R9754 |
T12188 |
T12189 |
compound |
cell,lines |
R9755 |
T12189 |
T12185 |
pobj |
lines,in |
R9756 |
T11995 |
T11993 |
prep |
including,members |
R9757 |
T12190 |
T12184 |
punct |
",",demonstrated |
R9758 |
T12191 |
T12184 |
cc |
but,demonstrated |
R9759 |
T12192 |
T12193 |
neg |
not,in |
R9760 |
T11996 |
T11995 |
pobj |
TGF-β1,including |
R9761 |
T12193 |
T12184 |
conj |
in,demonstrated |
R9762 |
T12194 |
T12193 |
pobj |
humans,in |
R9763 |
T12195 |
T12197 |
nmod |
[,] |
R9764 |
T11997 |
T11996 |
cc |
and,TGF-β1 |
R9765 |
T12196 |
T12197 |
nummod |
54,] |
R9766 |
T12197 |
T12193 |
conj |
],in |
R9767 |
T12198 |
T12184 |
punct |
.,demonstrated |
R9768 |
T11998 |
T11999 |
compound |
BMP-4,[ |
R9769 |
T12199 |
T12216 |
prep |
In,described |
R9770 |
T11999 |
T11996 |
conj |
[,TGF-β1 |
R9771 |
T12200 |
T12199 |
pobj |
accordance,In |
R9772 |
T12201 |
T12200 |
prep |
with,accordance |
R9773 |
T12000 |
T12001 |
nummod |
50,] |
R9774 |
T12202 |
T12203 |
det |
these,findings |
R9775 |
T12203 |
T12201 |
pobj |
findings,with |
R9776 |
T12001 |
T11996 |
conj |
],TGF-β1 |
R9777 |
T12204 |
T12216 |
punct |
",",described |
R9778 |
T12205 |
T12208 |
amod |
other,lines |
R9779 |
T12206 |
T12208 |
amod |
human,lines |
R9780 |
T12002 |
T11982 |
punct |
",",are |
R9781 |
T12003 |
T11982 |
advcl |
indicating,are |
R9782 |
T12207 |
T12208 |
compound |
cell,lines |
R9783 |
T12208 |
T12216 |
nsubjpass |
lines,described |
R9784 |
T12209 |
T12208 |
prep |
of,lines |
R9786 |
T12210 |
T12209 |
pobj |
neutrophil,of |
R9787 |
T12211 |
T12210 |
cc |
and,neutrophil |
R9788 |
T12212 |
T12213 |
amod |
monocytic,origin |
R9789 |
T12213 |
T12210 |
conj |
origin,neutrophil |
R9790 |
T12214 |
T12216 |
aux |
have,described |
R9791 |
T12215 |
T12216 |
auxpass |
been,described |
R9792 |
T12216 |
T12216 |
ROOT |
described,described |
R9793 |
T12217 |
T12218 |
aux |
to,be |
R9794 |
T12218 |
T12216 |
xcomp |
be,described |
R9795 |
T12219 |
T12218 |
acomp |
negative,be |
R9796 |
T12220 |
T12218 |
prep |
for,be |
R9797 |
T12221 |
T12223 |
det |
the,transcript |
R9798 |
T12222 |
T12223 |
compound |
BMP-6,transcript |
R9799 |
T12223 |
T12220 |
pobj |
transcript,for |
R9800 |
T12224 |
T12226 |
quantmod |
[,] |
R9801 |
T12225 |
T12226 |
nummod |
20,] |
R9802 |
T12226 |
T12218 |
npadvmod |
],be |
R9803 |
T12227 |
T12216 |
punct |
.,described |
R9804 |
T12228 |
T12233 |
prep |
To,is |
R9805 |
T12229 |
T12230 |
poss |
our,knowledge |
R9806 |
T12230 |
T12228 |
pobj |
knowledge,To |
R9807 |
T12231 |
T12233 |
punct |
",",is |
R9808 |
T12232 |
T12233 |
expl |
there,is |
R9809 |
T12233 |
T12233 |
ROOT |
is,is |
R9810 |
T12234 |
T12233 |
advmod |
currently,is |
R9811 |
T12235 |
T12236 |
det |
no,report |
R9812 |
T12236 |
T12233 |
attr |
report,is |
R9813 |
T12237 |
T12236 |
prep |
about,report |
R9814 |
T12238 |
T12239 |
compound |
BMP-6,production |
R9815 |
T12239 |
T12237 |
pobj |
production,about |
R9816 |
T12240 |
T12239 |
prep |
of,production |
R9817 |
T12241 |
T12243 |
amod |
human,cells |
R9818 |
T12242 |
T12243 |
amod |
dendritic,cells |
R9819 |
T12243 |
T12240 |
pobj |
cells,of |
R9820 |
T12244 |
T12233 |
punct |
.,is |