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PMC:1064873 JSONTXT 34 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1547 0-10 NN denotes Resistance
T1548 11-13 TO denotes to
T1549 14-19 NNP denotes IL-10
T1550 20-30 NN denotes inhibition
T1551 31-33 IN denotes of
T1552 34-44 NN denotes interferon
T1553 45-50 NN denotes gamma
T1554 51-61 NN denotes production
T1555 62-65 CC denotes and
T1556 66-76 NN denotes expression
T1557 77-79 IN denotes of
T1558 80-90 NN denotes suppressor
T1559 91-93 IN denotes of
T1560 94-102 NN denotes cytokine
T1561 103-112 VBG denotes signaling
T1562 113-114 CD denotes 1
T1563 115-117 IN denotes in
T1564 118-121 CD denotes CD4
T1565 121-122 CD denotes +
T1566 123-124 NNP denotes T
T1567 125-130 NNS denotes cells
T1568 131-135 IN denotes from
T1569 136-144 NNS denotes patients
T1570 145-149 IN denotes with
T1571 150-160 JJ denotes rheumatoid
T1572 161-170 NNS denotes arthritis
T1573 181-186 NNP denotes IL-10
T1574 187-190 VBZ denotes has
T1575 191-195 VBN denotes been
T1576 196-201 VBN denotes shown
T1577 202-204 TO denotes to
T1578 205-210 VB denotes block
T1579 211-214 DT denotes the
T1580 215-231 JJ denotes antigen-specific
T1581 232-238 NN denotes T-cell
T1582 239-247 NN denotes cytokine
T1583 248-256 NN denotes response
T1584 257-259 IN denotes by
T1585 260-270 VBG denotes inhibiting
T1586 271-274 DT denotes the
T1587 275-279 NNP denotes CD28
T1588 280-289 VBG denotes signaling
T1589 290-297 NN denotes pathway
T1590 297-298 . denotes .
T1591 299-301 PRP denotes We
T1592 302-307 VBD denotes found
T1593 308-312 IN denotes that
T1594 313-323 JJ denotes peripheral
T1595 324-329 NN denotes blood
T1596 330-333 NNP denotes CD4
T1597 333-334 NNP denotes +
T1598 335-336 NNP denotes T
T1599 337-342 NNS denotes cells
T1600 343-347 IN denotes from
T1601 348-356 NNS denotes patients
T1602 357-361 IN denotes with
T1603 362-368 JJ denotes active
T1604 369-379 JJ denotes rheumatoid
T1605 380-389 NNS denotes arthritis
T1606 390-391 -LRB- denotes (
T1607 391-393 NNP denotes RA
T1608 393-394 -RRB- denotes )
T1609 395-399 VBD denotes were
T1610 400-404 JJ denotes able
T1611 405-407 TO denotes to
T1612 408-415 VB denotes produce
T1613 416-423 JJR denotes greater
T1614 424-431 NNS denotes amounts
T1615 432-434 IN denotes of
T1616 435-445 NN denotes interferon
T1617 446-451 NN denotes gamma
T1618 452-457 IN denotes after
T1619 458-461 NNP denotes CD3
T1620 462-465 CC denotes and
T1621 466-470 NNP denotes CD28
T1622 471-484 NN denotes costimulation
T1623 485-487 IN denotes in
T1624 488-491 DT denotes the
T1625 492-500 NN denotes presence
T1626 501-503 IN denotes of
T1627 504-505 CD denotes 1
T1628 506-511 NN denotes ng/ml
T1629 512-517 NN denotes IL-10
T1630 518-522 IN denotes than
T1631 523-527 VBD denotes were
T1632 528-534 JJ denotes normal
T1633 535-542 NN denotes control
T1634 543-546 NNP denotes CD4
T1635 546-547 NNP denotes +
T1636 548-549 NNP denotes T
T1637 550-555 NNS denotes cells
T1638 555-556 , denotes ,
T1639 557-565 IN denotes although
T1640 566-571 PRP$ denotes their
T1641 572-579 NN denotes surface
T1642 580-590 NN denotes expression
T1643 591-593 IN denotes of
T1644 594-597 DT denotes the
T1645 598-602 NN denotes type
T1646 603-604 CD denotes 1
T1647 605-610 NN denotes IL-10
T1648 611-619 NN denotes receptor
T1649 620-623 VBD denotes was
T1650 624-633 VBN denotes increased
T1651 633-634 . denotes .
T1652 635-638 DT denotes The
T1653 639-654 NN denotes phosphorylation
T1654 655-657 IN denotes of
T1655 658-664 NN denotes signal
T1656 665-675 NN denotes transducer
T1657 676-679 CC denotes and
T1658 680-689 NN denotes activator
T1659 690-692 IN denotes of
T1660 693-706 NN denotes transcription
T1661 707-708 CD denotes 3
T1662 709-712 VBD denotes was
T1663 713-722 VBN denotes sustained
T1664 723-725 IN denotes in
T1665 726-730 DT denotes both
T1666 731-736 NN denotes blood
T1667 737-740 CC denotes and
T1668 741-749 JJ denotes synovial
T1669 750-756 NN denotes tissue
T1670 757-760 NNP denotes CD4
T1671 760-761 NNP denotes +
T1672 762-763 NNP denotes T
T1673 764-769 NNS denotes cells
T1674 770-772 IN denotes of
T1675 773-775 NNP denotes RA
T1676 775-776 , denotes ,
T1677 777-780 CC denotes but
T1678 781-783 PRP denotes it
T1679 784-787 VBD denotes was
T1680 788-791 RB denotes not
T1681 792-801 VBN denotes augmented
T1682 802-804 IN denotes by
T1683 805-808 DT denotes the
T1684 809-817 NN denotes presence
T1685 818-820 IN denotes of
T1686 821-822 CD denotes 1
T1687 823-828 NN denotes ng/ml
T1688 829-834 NN denotes IL-10
T1689 834-835 . denotes .
T1690 836-840 NNP denotes Sera
T1691 841-845 IN denotes from
T1692 846-848 NNP denotes RA
T1693 849-857 NNS denotes patients
T1694 858-865 VBD denotes induced
T1695 866-872 NN denotes signal
T1696 873-883 NN denotes transducer
T1697 884-887 CC denotes and
T1698 888-897 NN denotes activator
T1699 898-900 IN denotes of
T1700 901-914 NN denotes transcription
T1701 915-916 CD denotes 3
T1702 917-932 NN denotes phosphorylation
T1703 933-935 IN denotes in
T1704 936-942 JJ denotes normal
T1705 943-946 NNP denotes CD4
T1706 946-947 CD denotes +
T1707 948-949 NNP denotes T
T1708 950-955 NNS denotes cells
T1709 955-956 , denotes ,
T1710 957-962 WDT denotes which
T1711 963-966 VBD denotes was
T1712 967-973 RB denotes mostly
T1713 974-983 VBN denotes abolished
T1714 984-986 IN denotes by
T1715 987-999 VBG denotes neutralizing
T1716 1000-1009 JJ denotes anti-IL-6
T1717 1010-1018 NN denotes antibody
T1718 1018-1019 . denotes .
T1719 1020-1033 NN denotes Preincubation
T1720 1034-1036 IN denotes of
T1721 1037-1043 JJ denotes normal
T1722 1044-1047 NNP denotes CD4
T1723 1047-1048 CD denotes +
T1724 1049-1050 NNP denotes T
T1725 1051-1056 NNS denotes cells
T1726 1057-1061 IN denotes with
T1727 1062-1066 NNP denotes IL-6
T1728 1067-1074 VBD denotes reduced
T1729 1075-1089 JJ denotes IL-10-mediated
T1730 1090-1100 NN denotes inhibition
T1731 1101-1103 IN denotes of
T1732 1104-1114 NN denotes interferon
T1733 1115-1120 NN denotes gamma
T1734 1121-1131 NN denotes production
T1735 1131-1132 . denotes .
T1736 1133-1138 NNP denotes Blood
T1737 1139-1142 NNP denotes CD4
T1738 1142-1143 VBD denotes +
T1739 1144-1145 NNP denotes T
T1740 1146-1151 NNS denotes cells
T1741 1152-1156 IN denotes from
T1742 1157-1159 NNP denotes RA
T1743 1160-1168 NNS denotes patients
T1744 1169-1178 VBD denotes contained
T1745 1179-1185 JJR denotes higher
T1746 1186-1192 NNS denotes levels
T1747 1193-1195 IN denotes of
T1748 1196-1206 NN denotes suppressor
T1749 1207-1209 IN denotes of
T1750 1210-1218 NN denotes cytokine
T1751 1219-1228 VBG denotes signaling
T1752 1229-1230 CD denotes 1
T1753 1231-1234 CC denotes but
T1754 1235-1240 JJR denotes lower
T1755 1241-1247 NNS denotes levels
T1756 1248-1250 IN denotes of
T1757 1251-1261 NN denotes suppressor
T1758 1262-1264 IN denotes of
T1759 1265-1273 NN denotes cytokine
T1760 1274-1283 VBG denotes signaling
T1761 1284-1285 CD denotes 3
T1762 1286-1290 NNP denotes mRNA
T1763 1291-1299 VBN denotes compared
T1764 1300-1304 IN denotes with
T1765 1305-1312 NN denotes control
T1766 1313-1316 NNP denotes CD4
T1767 1316-1317 NNP denotes +
T1768 1318-1319 NNP denotes T
T1769 1320-1325 NNS denotes cells
T1770 1325-1326 , denotes ,
T1771 1327-1329 IN denotes as
T1772 1330-1340 VBN denotes determined
T1773 1341-1343 IN denotes by
T1774 1344-1353 JJ denotes real-time
T1775 1354-1357 NNP denotes PCR
T1776 1357-1358 . denotes .
T1777 1359-1364 DT denotes These
T1778 1365-1372 NNS denotes results
T1779 1373-1381 VBP denotes indicate
T1780 1382-1386 IN denotes that
T1781 1387-1389 NNP denotes RA
T1782 1390-1393 NNP denotes CD4
T1783 1393-1394 VBD denotes +
T1784 1395-1396 NNP denotes T
T1785 1397-1402 NNS denotes cells
T1786 1403-1409 VBP denotes become
T1787 1410-1419 JJ denotes resistant
T1788 1420-1422 TO denotes to
T1789 1423-1426 DT denotes the
T1790 1427-1444 JJ denotes immunosuppressive
T1791 1445-1451 NN denotes effect
T1792 1452-1454 IN denotes of
T1793 1455-1460 NN denotes IL-10
T1794 1461-1467 IN denotes before
T1795 1468-1477 NN denotes migration
T1796 1478-1482 IN denotes into
T1797 1483-1491 JJ denotes synovial
T1798 1492-1498 NN denotes tissue
T1799 1498-1499 , denotes ,
T1800 1500-1503 CC denotes and
T1801 1504-1508 DT denotes this
T1802 1509-1517 VBN denotes impaired
T1803 1518-1523 NN denotes IL-10
T1804 1524-1533 VBG denotes signaling
T1805 1534-1537 MD denotes may
T1806 1538-1540 VB denotes be
T1807 1541-1551 VBN denotes associated
T1808 1552-1556 IN denotes with
T1809 1557-1566 VBN denotes sustained
T1810 1567-1573 NN denotes signal
T1811 1574-1584 NN denotes transducer
T1812 1585-1588 CC denotes and
T1813 1589-1598 NN denotes activator
T1814 1599-1601 IN denotes of
T1815 1602-1615 NN denotes transcription
T1816 1616-1617 CD denotes 3
T1817 1618-1628 NN denotes activation
T1818 1629-1632 CC denotes and
T1819 1633-1643 NN denotes suppressor
T1820 1644-1646 IN denotes of
T1821 1647-1655 NN denotes cytokine
T1822 1656-1665 VBG denotes signaling
T1823 1666-1667 CD denotes 1
T1824 1668-1677 NN denotes induction
T1825 1677-1678 . denotes .
T4915 1693-1698 NN denotes IL-10
T4916 1699-1701 VBZ denotes is
T4917 1702-1703 DT denotes a
T4918 1704-1707 JJ denotes key
T4919 1708-1716 NN denotes cytokine
T4920 1717-1719 IN denotes in
T4921 1720-1730 VBG denotes regulating
T4922 1731-1743 JJ denotes inflammatory
T4923 1744-1753 NNS denotes responses
T4924 1753-1754 , denotes ,
T4925 1755-1761 RB denotes mainly
T4926 1762-1764 IN denotes by
T4927 1765-1775 VBG denotes inhibiting
T4928 1776-1779 DT denotes the
T4929 1780-1790 NN denotes production
T4930 1791-1794 CC denotes and
T4931 1795-1803 NN denotes function
T4932 1804-1806 IN denotes of
T4933 1807-1822 JJ denotes proinflammatory
T4934 1823-1832 NNS denotes cytokines
T4935 1832-1833 . denotes .
T4936 1834-1839 JJ denotes IL-10
T4937 1840-1845 NNS denotes binds
T4938 1846-1848 TO denotes to
T4939 1849-1852 DT denotes the
T4940 1853-1858 NN denotes IL-10
T4941 1859-1867 NN denotes receptor
T4942 1868-1869 -LRB- denotes (
T4943 1869-1875 NN denotes IL-10R
T4944 1875-1876 -RRB- denotes )
T4945 1877-1884 NN denotes complex
T4946 1885-1889 WDT denotes that
T4947 1890-1892 VBZ denotes is
T4948 1893-1901 VBN denotes composed
T4949 1902-1904 IN denotes of
T4950 1905-1908 CD denotes two
T4951 1909-1917 NNS denotes subunits
T4952 1917-1918 , denotes ,
T4953 1919-1922 DT denotes the
T4954 1923-1930 JJ denotes primary
T4955 1931-1945 JJ denotes ligand-binding
T4956 1946-1955 NN denotes component
T4957 1956-1960 NN denotes type
T4958 1961-1962 CD denotes 1
T4959 1963-1969 NN denotes IL-10R
T4960 1970-1971 -LRB- denotes (
T4961 1971-1978 NN denotes IL-10R1
T4962 1978-1979 -RRB- denotes )
T4963 1980-1983 CC denotes and
T4964 1984-1987 DT denotes the
T4965 1988-1997 JJ denotes accessory
T4966 1998-2007 NN denotes component
T4967 2008-2012 NN denotes type
T4968 2013-2014 CD denotes 2
T4969 2015-2021 NNP denotes IL-10R
T4970 2022-2023 NNP denotes [
T4971 2023-2024 CD denotes 1
T4972 2024-2025 NNP denotes ]
T4973 2025-2026 . denotes .
T4974 2027-2030 DT denotes The
T4975 2031-2042 NN denotes interaction
T4976 2043-2045 IN denotes of
T4977 2046-2051 NNP denotes IL-10
T4978 2052-2055 CC denotes and
T4979 2056-2062 NNP denotes IL-10R
T4980 2063-2070 VBZ denotes engages
T4981 2071-2074 DT denotes the
T4982 2075-2080 NNP denotes Janus
T4983 2081-2087 NN denotes kinase
T4984 2088-2089 -LRB- denotes (
T4985 2089-2092 NNP denotes JAK
T4986 2092-2093 -RRB- denotes )
T4987 2094-2100 NN denotes family
T4988 2101-2109 NN denotes tyrosine
T4989 2110-2117 VBZ denotes kinases
T4990 2118-2122 NNP denotes Jak1
T4991 2123-2126 CC denotes and
T4992 2127-2131 NNP denotes Tyk2
T4993 2131-2132 , denotes ,
T4994 2133-2138 WDT denotes which
T4995 2139-2142 VBP denotes are
T4996 2143-2157 RB denotes constitutively
T4997 2158-2168 VBN denotes associated
T4998 2169-2173 IN denotes with
T4999 2174-2181 NNP denotes IL-10R1
T5000 2182-2185 CC denotes and
T5001 2186-2190 NN denotes type
T5002 2191-2192 CD denotes 2
T5003 2193-2199 NN denotes IL-10R
T5004 2199-2200 , denotes ,
T5005 2201-2213 RB denotes respectively
T5006 2214-2215 JJ denotes [
T5007 2215-2216 CD denotes 2
T5008 2216-2217 NN denotes ]
T5009 2217-2218 . denotes .
T5010 2219-2224 NN denotes IL-10
T5011 2225-2232 VBZ denotes induces
T5012 2233-2241 JJ denotes tyrosine
T5013 2242-2257 NN denotes phosphorylation
T5014 2258-2261 CC denotes and
T5015 2262-2272 NN denotes activation
T5016 2273-2275 IN denotes of
T5017 2276-2279 DT denotes the
T5018 2280-2286 NN denotes latent
T5019 2287-2302 JJ denotes transcriptional
T5020 2303-2310 NNS denotes factors
T5021 2311-2317 VBP denotes signal
T5022 2318-2328 NN denotes transducer
T5023 2329-2332 CC denotes and
T5024 2333-2342 NN denotes activator
T5025 2343-2345 IN denotes of
T5026 2346-2359 NN denotes transcription
T5027 2360-2361 -LRB- denotes (
T5028 2361-2365 NNP denotes STAT
T5029 2365-2366 -RRB- denotes )
T5030 2367-2368 CD denotes 3
T5031 2369-2372 CC denotes and
T5032 2373-2378 CD denotes STAT1
T5033 2379-2380 NN denotes [
T5034 2380-2381 CD denotes 3
T5035 2381-2382 NNP denotes ]
T5036 2382-2383 . denotes .
T5037 2384-2388 IN denotes Upon
T5038 2389-2404 NN denotes phosphorylation
T5039 2404-2405 , denotes ,
T5040 2406-2411 NNP denotes STAT1
T5041 2412-2415 CC denotes and
T5042 2416-2421 NNP denotes STAT3
T5043 2422-2430 NNS denotes proteins
T5044 2431-2435 VBP denotes form
T5045 2436-2446 NNS denotes homodimers
T5046 2447-2449 CC denotes or
T5047 2450-2462 NNS denotes heterodimers
T5048 2462-2463 , denotes ,
T5049 2464-2471 RB denotes rapidly
T5050 2472-2483 VBP denotes translocate
T5051 2484-2488 IN denotes into
T5052 2489-2492 DT denotes the
T5053 2493-2500 NN denotes nucleus
T5054 2500-2501 , denotes ,
T5055 2502-2505 CC denotes and
T5056 2506-2514 VB denotes modulate
T5057 2515-2519 NN denotes gene
T5058 2520-2533 NN denotes transcription
T5059 2533-2534 . denotes .
T5060 2535-2547 RB denotes Intriguingly
T5061 2547-2548 , denotes ,
T5062 2549-2554 NNP denotes STAT3
T5063 2555-2557 VBZ denotes is
T5064 2558-2571 JJ denotes indispensable
T5065 2572-2575 IN denotes for
T5066 2576-2580 DT denotes both
T5067 2581-2594 JJ denotes IL-10-derived
T5068 2595-2612 JJ denotes anti-inflammatory
T5069 2613-2616 CC denotes and
T5070 2617-2629 JJ denotes IL-6-derived
T5071 2630-2645 JJ denotes proinflammatory
T5072 2646-2655 NNS denotes responses
T5073 2656-2657 VBP denotes [
T5074 2657-2658 CD denotes 4
T5075 2658-2659 NNP denotes ]
T5076 2659-2660 . denotes .
T5077 2661-2668 NNS denotes Studies
T5078 2669-2671 IN denotes of
T5079 2672-2690 JJ denotes cell-type-specific
T5080 2691-2706 JJ denotes STAT3-deficient
T5081 2707-2711 NNS denotes mice
T5082 2712-2716 VBP denotes have
T5083 2717-2722 VBN denotes shown
T5084 2723-2727 IN denotes that
T5085 2728-2733 CD denotes STAT3
T5086 2734-2744 NN denotes activation
T5087 2745-2747 VBZ denotes is
T5088 2748-2757 JJ denotes essential
T5089 2758-2761 IN denotes for
T5090 2762-2776 JJ denotes IL-10-mediated
T5091 2777-2794 JJ denotes anti-inflammatory
T5092 2795-2804 NNS denotes reactions
T5093 2805-2807 IN denotes in
T5094 2808-2819 NNS denotes macrophages
T5095 2820-2823 CC denotes and
T5096 2824-2835 NNS denotes neutrophils
T5097 2836-2837 VBP denotes [
T5098 2837-2838 CD denotes 5
T5099 2838-2839 NNP denotes ]
T5100 2839-2840 , denotes ,
T5101 2841-2844 CC denotes but
T5102 2845-2847 VBZ denotes is
T5103 2848-2859 JJ denotes responsible
T5104 2860-2863 IN denotes for
T5105 2864-2877 JJ denotes IL-6-mediated
T5106 2878-2888 NN denotes prevention
T5107 2889-2891 IN denotes of
T5108 2892-2901 NN denotes apoptosis
T5109 2902-2904 IN denotes in
T5110 2905-2906 NNP denotes T
T5111 2907-2912 NNS denotes cells
T5112 2913-2914 NNP denotes [
T5113 2914-2915 CD denotes 6
T5114 2915-2916 NNP denotes ]
T5115 2916-2917 . denotes .
T5116 2918-2921 DT denotes The
T5117 2922-2932 NN denotes suppressor
T5118 2933-2935 IN denotes of
T5119 2936-2944 NN denotes cytokine
T5120 2945-2954 VBG denotes signaling
T5121 2955-2956 -LRB- denotes (
T5122 2956-2960 NNP denotes SOCS
T5123 2960-2961 -RRB- denotes )
T5124 2962-2970 NNS denotes proteins
T5125 2971-2975 VBP denotes have
T5126 2976-2980 VBN denotes been
T5127 2981-2991 VBN denotes identified
T5128 2992-2994 IN denotes as
T5129 2995-2996 DT denotes a
T5130 2997-3003 NN denotes family
T5131 3004-3006 IN denotes of
T5132 3007-3017 JJ denotes endogenous
T5133 3018-3021 NNP denotes JAK
T5134 3022-3028 NN denotes kinase
T5135 3029-3039 NNS denotes inhibitors
T5136 3040-3044 WDT denotes that
T5137 3045-3048 MD denotes can
T5138 3049-3052 VB denotes act
T5139 3053-3055 IN denotes in
T5140 3056-3063 JJ denotes classic
T5141 3064-3072 NN denotes feedback
T5142 3073-3083 NN denotes inhibition
T5143 3084-3089 NNS denotes loops
T5144 3089-3090 , denotes ,
T5145 3091-3094 CC denotes but
T5146 3095-3100 PRP$ denotes their
T5147 3101-3106 NNS denotes roles
T5148 3107-3109 IN denotes as
T5149 3110-3113 DT denotes the
T5150 3114-3123 NNS denotes mediators
T5151 3124-3126 IN denotes of
T5152 3127-3136 NN denotes crosstalk
T5153 3137-3147 NN denotes inhibition
T5154 3148-3150 IN denotes by
T5155 3151-3159 VBG denotes opposing
T5156 3160-3168 NN denotes cytokine
T5157 3169-3178 VBG denotes signaling
T5158 3179-3187 NNS denotes pathways
T5159 3188-3192 VBP denotes have
T5160 3193-3197 VBN denotes been
T5161 3198-3207 VBN denotes clarified
T5162 3208-3209 NNP denotes [
T5163 3209-3210 CD denotes 7
T5164 3210-3211 NNP denotes ]
T5165 3211-3212 . denotes .
T5166 3213-3219 JJ denotes Recent
T5167 3220-3227 NNS denotes studies
T5168 3228-3236 VBP denotes indicate
T5169 3237-3241 IN denotes that
T5170 3242-3247 CD denotes SOCS3
T5171 3248-3253 VBZ denotes plays
T5172 3254-3255 DT denotes a
T5173 3256-3259 JJ denotes key
T5174 3260-3264 NN denotes role
T5175 3265-3267 IN denotes in
T5176 3268-3278 VBG denotes regulating
T5177 3279-3282 DT denotes the
T5178 3283-3292 JJ denotes divergent
T5179 3293-3299 NN denotes action
T5180 3300-3302 IN denotes of
T5181 3303-3308 NNP denotes IL-10
T5182 3309-3312 CC denotes and
T5183 3313-3317 NNP denotes IL-6
T5184 3317-3318 , denotes ,
T5185 3319-3321 IN denotes by
T5186 3322-3334 RB denotes specifically
T5187 3335-3343 VBG denotes blocking
T5188 3344-3349 CD denotes STAT3
T5189 3350-3360 NN denotes activation
T5190 3361-3368 VBN denotes induced
T5191 3369-3371 IN denotes by
T5192 3372-3376 NN denotes IL-6
T5193 3377-3380 CC denotes but
T5194 3381-3384 RB denotes not
T5195 3385-3389 IN denotes that
T5196 3390-3397 VBN denotes induced
T5197 3398-3400 IN denotes by
T5198 3401-3406 NNP denotes IL-10
T5199 3407-3408 NNP denotes [
T5200 3408-3411 CD denotes 8,9
T5201 3411-3412 NNP denotes ]
T5202 3412-3413 . denotes .
T5203 3414-3417 DT denotes The
T5204 3418-3426 JJ denotes synovial
T5205 3427-3435 NN denotes membrane
T5206 3436-3438 IN denotes of
T5207 3439-3449 JJ denotes rheumatoid
T5208 3450-3459 NNS denotes arthritis
T5209 3460-3461 -LRB- denotes (
T5210 3461-3463 NNP denotes RA
T5211 3463-3464 -RRB- denotes )
T5212 3465-3467 VBZ denotes is
T5213 3468-3481 VBN denotes characterized
T5214 3482-3484 IN denotes by
T5215 3485-3487 DT denotes an
T5216 3488-3498 VB denotes infiltrate
T5217 3499-3501 IN denotes of
T5218 3502-3503 DT denotes a
T5219 3504-3511 NN denotes variety
T5220 3512-3514 IN denotes of
T5221 3515-3527 JJ denotes inflammatory
T5222 3528-3533 NNS denotes cells
T5223 3533-3534 , denotes ,
T5224 3535-3539 JJ denotes such
T5225 3540-3542 IN denotes as
T5226 3543-3554 NNS denotes lymphocytes
T5227 3554-3555 , denotes ,
T5228 3556-3567 NNS denotes macrophages
T5229 3567-3568 , denotes ,
T5230 3569-3572 CC denotes and
T5231 3573-3582 JJ denotes dendritic
T5232 3583-3588 NNS denotes cells
T5233 3588-3589 , denotes ,
T5234 3590-3598 RB denotes together
T5235 3599-3603 IN denotes with
T5236 3604-3617 NN denotes proliferation
T5237 3618-3620 IN denotes of
T5238 3621-3629 JJ denotes synovial
T5239 3630-3645 JJ denotes fibroblast-like
T5240 3646-3651 NNS denotes cells
T5241 3651-3652 . denotes .
T5242 3653-3661 JJ denotes Numerous
T5243 3662-3671 NNS denotes cytokines
T5244 3672-3675 VBP denotes are
T5245 3676-3688 VBN denotes overproduced
T5246 3689-3691 IN denotes in
T5247 3692-3695 DT denotes the
T5248 3696-3704 JJ denotes inflamed
T5249 3705-3710 NN denotes joint
T5250 3710-3711 , denotes ,
T5251 3712-3715 CC denotes and
T5252 3716-3727 NNS denotes macrophages
T5253 3728-3731 CC denotes and
T5254 3732-3740 JJ denotes synovial
T5255 3741-3752 NNS denotes fibroblasts
T5256 3753-3756 VBP denotes are
T5257 3757-3759 DT denotes an
T5258 3760-3769 JJ denotes important
T5259 3770-3776 NN denotes source
T5260 3777-3779 IN denotes of
T5261 3780-3795 JJ denotes proinflammatory
T5262 3796-3805 NNS denotes cytokines
T5263 3805-3806 . denotes .
T5264 3807-3812 NN denotes Tumor
T5265 3813-3821 NN denotes necrosis
T5266 3822-3828 NN denotes factor
T5267 3829-3834 NN denotes alpha
T5268 3835-3836 -LRB- denotes (
T5269 3836-3841 NNP denotes TNF-α
T5270 3841-3842 -RRB- denotes )
T5271 3843-3846 CC denotes and
T5272 3847-3851 NNP denotes IL-1
T5273 3851-3852 , denotes ,
T5274 3853-3856 CD denotes two
T5275 3857-3862 JJ denotes major
T5276 3863-3873 NN denotes macrophage
T5277 3874-3882 NNS denotes products
T5278 3882-3883 , denotes ,
T5279 3884-3887 VBP denotes are
T5280 3888-3895 JJ denotes crucial
T5281 3896-3898 IN denotes in
T5282 3899-3902 DT denotes the
T5283 3903-3910 NN denotes process
T5284 3911-3913 IN denotes of
T5285 3914-3921 JJ denotes chronic
T5286 3922-3934 NN denotes inflammation
T5287 3935-3938 CC denotes and
T5288 3939-3944 JJ denotes joint
T5289 3945-3956 NN denotes destruction
T5290 3956-3957 , denotes ,
T5291 3958-3961 CC denotes and
T5292 3962-3966 PRP denotes they
T5293 3967-3971 VBP denotes give
T5294 3972-3976 VB denotes rise
T5295 3977-3979 TO denotes to
T5296 3980-3988 VB denotes effector
T5297 3989-3999 NNS denotes components
T5298 3999-4000 , denotes ,
T5299 4001-4010 VBG denotes including
T5300 4011-4016 JJ denotes other
T5301 4017-4029 JJ denotes inflammatory
T5302 4030-4039 NNS denotes cytokines
T5303 4039-4040 , denotes ,
T5304 4041-4051 NNS denotes chemokines
T5305 4051-4052 , denotes ,
T5306 4053-4059 NN denotes growth
T5307 4060-4067 NNS denotes factors
T5308 4067-4068 , denotes ,
T5309 4069-4075 NN denotes matrix
T5310 4076-4085 NNS denotes proteases
T5311 4085-4086 , denotes ,
T5312 4087-4093 JJ denotes nitric
T5313 4094-4099 NN denotes oxide
T5314 4099-4100 , denotes ,
T5315 4101-4104 CC denotes and
T5316 4105-4113 JJ denotes reactive
T5317 4114-4120 NN denotes oxygen
T5318 4121-4128 NNS denotes species
T5319 4129-4130 NNP denotes [
T5320 4130-4132 CD denotes 10
T5321 4132-4133 NNP denotes ]
T5322 4133-4134 . denotes .
T5323 4135-4139 NN denotes IL-6
T5324 4140-4142 VBZ denotes is
T5325 4143-4144 DT denotes a
T5326 4145-4156 JJ denotes pleiotropic
T5327 4157-4165 NN denotes cytokine
T5328 4166-4174 VBD denotes produced
T5329 4175-4188 RB denotes substantially
T5330 4189-4191 IN denotes by
T5331 4192-4201 VBN denotes activated
T5332 4202-4213 NNS denotes fibroblasts
T5333 4213-4214 , denotes ,
T5334 4215-4218 CC denotes and
T5335 4219-4222 PRP$ denotes its
T5336 4223-4238 JJ denotes proinflammatory
T5337 4239-4246 NNS denotes actions
T5338 4247-4254 VBP denotes include
T5339 4255-4265 VBG denotes simulating
T5340 4266-4269 DT denotes the
T5341 4270-4281 JJ denotes acute-phase
T5342 4282-4290 NN denotes response
T5343 4290-4291 , denotes ,
T5344 4292-4298 NNP denotes B-cell
T5345 4299-4309 NN denotes maturation
T5346 4310-4314 IN denotes into
T5347 4315-4321 NN denotes plasma
T5348 4322-4327 NNS denotes cells
T5349 4327-4328 , denotes ,
T5350 4329-4335 NNP denotes T-cell
T5351 4336-4345 NNS denotes functions
T5352 4345-4346 , denotes ,
T5353 4347-4350 CC denotes and
T5354 4351-4364 JJ denotes hematopoietic
T5355 4365-4374 NN denotes precursor
T5356 4375-4379 NN denotes cell
T5357 4380-4395 NN denotes differentiation
T5358 4396-4397 NNP denotes [
T5359 4397-4399 CD denotes 11
T5360 4399-4400 NNP denotes ]
T5361 4400-4401 . denotes .
T5362 4402-4409 RB denotes However
T5363 4409-4410 , denotes ,
T5364 4411-4428 JJ denotes anti-inflammatory
T5365 4429-4438 NNS denotes cytokines
T5366 4439-4442 CC denotes and
T5367 4443-4451 NN denotes cytokine
T5368 4452-4462 NNS denotes inhibitors
T5369 4463-4466 VBP denotes are
T5370 4467-4471 RB denotes also
T5371 4472-4479 JJ denotes present
T5372 4480-4482 IN denotes in
T5373 4483-4488 JJ denotes large
T5374 4489-4499 NNS denotes quantities
T5375 4500-4502 IN denotes in
T5376 4503-4505 NNP denotes RA
T5377 4506-4512 NNS denotes joints
T5378 4512-4513 . denotes .
T5379 4514-4519 NN denotes IL-10
T5380 4519-4520 , denotes ,
T5381 4521-4529 VBN denotes produced
T5382 4530-4532 IN denotes by
T5383 4533-4544 NNS denotes macrophages
T5384 4545-4548 CC denotes and
T5385 4549-4555 RB denotes partly
T5386 4556-4558 IN denotes by
T5387 4559-4560 NNP denotes T
T5388 4561-4566 NNS denotes cells
T5389 4567-4569 IN denotes in
T5390 4570-4573 DT denotes the
T5391 4574-4582 JJ denotes synovial
T5392 4583-4589 NN denotes tissue
T5393 4590-4591 -LRB- denotes (
T5394 4591-4593 NNP denotes ST
T5395 4593-4594 -RRB- denotes )
T5396 4594-4595 , denotes ,
T5397 4596-4598 VBZ denotes is
T5398 4599-4603 RB denotes best
T5399 4604-4609 VBN denotes known
T5400 4610-4612 IN denotes as
T5401 4613-4614 DT denotes a
T5402 4615-4623 JJ denotes negative
T5403 4624-4633 NN denotes regulator
T5404 4634-4637 IN denotes for
T5405 4638-4648 NN denotes macrophage
T5406 4649-4652 CC denotes and
T5407 4653-4656 JJ denotes Th1
T5408 4657-4662 NNS denotes cells
T5409 4662-4663 , denotes ,
T5410 4664-4667 CC denotes but
T5411 4668-4671 DT denotes the
T5412 4672-4682 NN denotes expression
T5413 4683-4688 NN denotes level
T5414 4689-4691 VBZ denotes is
T5415 4692-4704 JJ denotes insufficient
T5416 4705-4707 TO denotes to
T5417 4708-4722 VB denotes counterbalance
T5418 4723-4726 DT denotes the
T5419 4727-4734 NN denotes cascade
T5420 4735-4737 IN denotes of
T5421 4738-4753 JJ denotes proinflammatory
T5422 4754-4760 NNS denotes events
T5423 4761-4762 NNP denotes [
T5424 4762-4764 CD denotes 12
T5425 4764-4765 NNP denotes ]
T5426 4765-4766 . denotes .
T5427 4767-4769 IN denotes In
T5428 4770-4778 NN denotes addition
T5429 4778-4779 , denotes ,
T5430 4780-4783 DT denotes the
T5431 4784-4801 JJ denotes anti-inflammatory
T5432 4802-4808 NN denotes action
T5433 4809-4811 IN denotes of
T5434 4812-4817 NN denotes IL-10
T5435 4818-4825 VBZ denotes appears
T5436 4826-4828 TO denotes to
T5437 4829-4831 VB denotes be
T5438 4832-4841 VBN denotes modulated
T5439 4842-4844 IN denotes at
T5440 4845-4848 DT denotes the
T5441 4849-4854 NN denotes level
T5442 4855-4857 IN denotes of
T5443 4858-4864 NN denotes signal
T5444 4865-4877 NN denotes transduction
T5445 4878-4884 IN denotes during
T5446 4885-4892 JJ denotes chronic
T5447 4893-4905 NN denotes inflammation
T5448 4905-4906 . denotes .
T5449 4907-4912 NN denotes IL-10
T5450 4913-4922 VBG denotes signaling
T5451 4923-4925 VBZ denotes is
T5452 4926-4934 VBN denotes impaired
T5453 4935-4937 IN denotes in
T5454 4938-4949 NNS denotes macrophages
T5455 4950-4954 IN denotes upon
T5456 4955-4962 JJ denotes chronic
T5457 4963-4971 NN denotes exposure
T5458 4972-4974 TO denotes to
T5459 4975-4990 JJ denotes proinflammatory
T5460 4991-5000 NNS denotes cytokines
T5461 5001-5005 JJ denotes such
T5462 5006-5008 IN denotes as
T5463 5009-5014 NNP denotes TNF-α
T5464 5015-5018 CC denotes and
T5465 5019-5023 NNP denotes IL-1
T5466 5024-5027 CC denotes and
T5467 5028-5034 JJ denotes immune
T5468 5035-5044 NNS denotes complexes
T5469 5045-5046 NNP denotes [
T5470 5046-5051 CD denotes 13,14
T5471 5051-5052 NNP denotes ]
T5472 5052-5053 . denotes .
T5473 5054-5058 NN denotes Cell
T5474 5059-5066 NN denotes surface
T5475 5067-5077 NN denotes expression
T5476 5078-5080 IN denotes of
T5477 5081-5088 NN denotes IL-10R1
T5478 5089-5091 VBZ denotes is
T5479 5092-5101 VBN denotes decreased
T5480 5102-5104 IN denotes in
T5481 5105-5113 JJ denotes synovial
T5482 5114-5119 NN denotes fluid
T5483 5120-5129 JJ denotes dendritic
T5484 5130-5135 NNS denotes cells
T5485 5136-5139 JJ denotes due
T5486 5140-5142 TO denotes to
T5487 5143-5146 DT denotes the
T5488 5147-5155 NN denotes presence
T5489 5156-5158 IN denotes of
T5490 5159-5164 NNP denotes TNF-α
T5491 5164-5165 , denotes ,
T5492 5166-5170 NNP denotes IL-1
T5493 5170-5171 , denotes ,
T5494 5172-5175 CC denotes and
T5495 5176-5187 NN denotes granulocyte
T5496 5188-5198 NN denotes macrophage
T5497 5199-5217 JJ denotes colony-stimulating
T5498 5218-5224 NN denotes factor
T5499 5225-5226 NNP denotes [
T5500 5226-5228 CD denotes 15
T5501 5228-5229 NNP denotes ]
T5502 5229-5230 . denotes .
T5503 5231-5234 CD denotes CD4
T5504 5234-5235 CD denotes +
T5505 5236-5237 NNP denotes T
T5506 5238-5243 NNS denotes cells
T5507 5244-5247 MD denotes may
T5508 5248-5250 VB denotes be
T5509 5251-5260 VBN denotes activated
T5510 5261-5263 IN denotes by
T5511 5264-5277 JJ denotes arthritogenic
T5512 5278-5286 NNS denotes antigens
T5513 5286-5287 , denotes ,
T5514 5288-5290 IN denotes in
T5515 5291-5302 NN denotes conjunction
T5516 5303-5307 IN denotes with
T5517 5308-5321 JJ denotes CD28-mediated
T5518 5322-5335 JJ denotes costimulatory
T5519 5336-5345 VBG denotes signaling
T5520 5345-5346 , denotes ,
T5521 5347-5349 IN denotes in
T5522 5350-5352 NNP denotes RA
T5523 5352-5353 . denotes .
T5524 5354-5357 DT denotes The
T5525 5358-5370 NN denotes significance
T5526 5371-5373 IN denotes of
T5527 5374-5378 DT denotes this
T5528 5379-5389 JJ denotes autoimmune
T5529 5390-5397 NN denotes process
T5530 5398-5401 VBZ denotes has
T5531 5402-5406 VBN denotes been
T5532 5407-5416 VBN denotes supported
T5533 5417-5419 IN denotes by
T5534 5420-5423 DT denotes the
T5535 5424-5431 NN denotes linkage
T5536 5432-5434 IN denotes of
T5537 5435-5438 DT denotes the
T5538 5439-5442 NNP denotes MHC
T5539 5443-5448 NN denotes class
T5540 5449-5451 NNP denotes II
T5541 5452-5460 VBZ denotes antigens
T5542 5461-5469 NNP denotes HLA-DRB1
T5543 5469-5470 SYM denotes *
T5544 5470-5474 CD denotes 0404
T5545 5475-5478 CC denotes and
T5546 5479-5487 NNP denotes HLA-DRB1
T5547 5487-5488 SYM denotes *
T5548 5488-5492 CD denotes 0401
T5549 5493-5497 IN denotes with
T5550 5498-5505 NN denotes disease
T5551 5506-5520 NN denotes susceptibility
T5552 5521-5524 CC denotes and
T5553 5525-5533 NN denotes severity
T5554 5534-5535 NNP denotes [
T5555 5535-5540 CD denotes 16,17
T5556 5540-5541 NNP denotes ]
T5557 5541-5542 , denotes ,
T5558 5543-5546 CC denotes and
T5559 5547-5549 IN denotes by
T5560 5550-5553 DT denotes the
T5561 5554-5564 JJ denotes high-level
T5562 5565-5575 NN denotes expression
T5563 5576-5578 IN denotes of
T5564 5579-5582 NNP denotes MHC
T5565 5583-5588 NN denotes class
T5566 5589-5591 NNP denotes II
T5567 5592-5601 NNS denotes molecules
T5568 5602-5605 CC denotes and
T5569 5606-5610 DT denotes both
T5570 5611-5615 CD denotes CD28
T5571 5616-5623 NNS denotes ligands
T5572 5623-5624 , denotes ,
T5573 5625-5629 NNP denotes CD80
T5574 5630-5633 CC denotes and
T5575 5634-5638 NNP denotes CD86
T5576 5638-5639 , denotes ,
T5577 5640-5642 IN denotes in
T5578 5643-5646 DT denotes the
T5579 5647-5655 JJ denotes inflamed
T5580 5656-5658 NNP denotes ST
T5581 5659-5660 NNP denotes [
T5582 5660-5665 CD denotes 18-20
T5583 5665-5666 NNP denotes ]
T5584 5666-5667 . denotes .
T5585 5668-5671 DT denotes The
T5586 5672-5682 VBG denotes continuing
T5587 5683-5692 NN denotes emergence
T5588 5693-5695 IN denotes of
T5589 5696-5705 VBN denotes activated
T5590 5706-5709 NNP denotes CD4
T5591 5709-5710 CD denotes +
T5592 5711-5712 NNP denotes T
T5593 5713-5718 NNS denotes cells
T5594 5718-5719 , denotes ,
T5595 5720-5724 RB denotes even
T5596 5725-5731 IN denotes though
T5597 5732-5735 JJ denotes few
T5598 5736-5738 IN denotes in
T5599 5739-5745 NN denotes number
T5600 5745-5746 , denotes ,
T5601 5747-5750 MD denotes may
T5602 5751-5753 VB denotes be
T5603 5754-5761 JJ denotes crucial
T5604 5762-5764 IN denotes in
T5605 5765-5775 VBG denotes sustaining
T5606 5776-5779 DT denotes the
T5607 5780-5790 NN denotes activation
T5608 5791-5793 IN denotes of
T5609 5794-5805 NNS denotes macrophages
T5610 5806-5809 CC denotes and
T5611 5810-5818 JJ denotes synovial
T5612 5819-5830 NNS denotes fibroblasts
T5613 5831-5838 IN denotes through
T5614 5839-5843 NN denotes cell
T5615 5844-5851 NN denotes surface
T5616 5852-5861 VBG denotes signaling
T5617 5862-5864 IN denotes by
T5618 5865-5870 NNS denotes means
T5619 5871-5873 IN denotes of
T5620 5874-5878 NN denotes cell
T5621 5879-5886 NN denotes surface
T5622 5887-5891 NNP denotes CD69
T5623 5892-5895 CC denotes and
T5624 5896-5900 NNP denotes CD11
T5625 5900-5901 , denotes ,
T5626 5902-5904 RB denotes as
T5627 5905-5909 RB denotes well
T5628 5910-5912 IN denotes as
T5629 5913-5916 DT denotes the
T5630 5917-5924 NN denotes release
T5631 5925-5927 IN denotes of
T5632 5928-5943 JJ denotes proinflammatory
T5633 5944-5947 JJ denotes Th1
T5634 5948-5957 NNS denotes cytokines
T5635 5958-5962 JJ denotes such
T5636 5963-5965 IN denotes as
T5637 5966-5976 NN denotes interferon
T5638 5977-5982 NN denotes gamma
T5639 5983-5984 -LRB- denotes (
T5640 5984-5987 NNP denotes IFN
T5641 5987-5988 -RRB- denotes )
T5642 5988-5989 : denotes -
T5643 5989-5990 NN denotes γ
T5644 5991-5994 CC denotes and
T5645 5995-6000 NNP denotes IL-17
T5646 6001-6002 NNP denotes [
T5647 6002-6007 CD denotes 21,22
T5648 6007-6008 NNP denotes ]
T5649 6008-6009 . denotes .
T5650 6010-6012 IN denotes In
T5651 6013-6021 NN denotes addition
T5652 6021-6022 , denotes ,
T5653 6023-6026 NNP denotes CD4
T5654 6026-6027 NNP denotes +
T5655 6028-6029 NNP denotes T
T5656 6030-6035 NNS denotes cells
T5657 6036-6041 MD denotes could
T5658 6042-6051 VB denotes stimulate
T5659 6052-6058 JJ denotes B-cell
T5660 6059-6069 NN denotes production
T5661 6070-6072 IN denotes of
T5662 6073-6087 NNS denotes autoantibodies
T5663 6088-6092 JJ denotes such
T5664 6093-6095 IN denotes as
T5665 6096-6106 JJ denotes rheumatoid
T5666 6107-6113 NN denotes factor
T5667 6114-6117 CC denotes and
T5668 6118-6137 JJ denotes osteoclast-mediated
T5669 6138-6142 NN denotes bone
T5670 6143-6154 NN denotes destruction
T5671 6154-6155 . denotes .
T5672 6156-6161 PRP$ denotes Their
T5673 6162-6172 JJ denotes obligatory
T5674 6173-6177 NN denotes role
T5675 6178-6180 IN denotes in
T5676 6181-6183 NNP denotes RA
T5677 6184-6193 NN denotes synovitis
T5678 6194-6197 VBD denotes was
T5679 6198-6206 RB denotes recently
T5680 6207-6213 VBN denotes proved
T5681 6214-6216 IN denotes by
T5682 6217-6227 JJ denotes successful
T5683 6228-6237 NN denotes treatment
T5684 6238-6240 IN denotes of
T5685 6241-6247 JJ denotes active
T5686 6248-6255 NN denotes disease
T5687 6256-6258 IN denotes by
T5688 6259-6268 JJ denotes selective
T5689 6269-6279 NN denotes inhibition
T5690 6280-6282 IN denotes of
T5691 6283-6289 NNP denotes T-cell
T5692 6290-6300 NN denotes activation
T5693 6301-6305 IN denotes with
T5694 6306-6312 NN denotes fusion
T5695 6313-6320 NN denotes protein
T5696 6321-6323 IN denotes of
T5697 6324-6333 JJ denotes cytotoxic
T5698 6334-6351 JJ denotes T-cell-associated
T5699 6352-6359 NN denotes antigen
T5700 6360-6361 CD denotes 4
T5701 6362-6363 -LRB- denotes (
T5702 6363-6368 NN denotes CD152
T5703 6368-6369 -RRB- denotes )
T5704 6369-6370 : denotes -
T5705 6370-6373 NNP denotes IgG
T5706 6373-6374 , denotes ,
T5707 6375-6380 WDT denotes which
T5708 6381-6384 MD denotes can
T5709 6385-6390 VB denotes block
T5710 6391-6394 DT denotes the
T5711 6395-6405 NN denotes engagement
T5712 6406-6408 IN denotes of
T5713 6409-6413 CD denotes CD28
T5714 6414-6416 IN denotes on
T5715 6417-6418 NNP denotes T
T5716 6419-6424 NNS denotes cells
T5717 6425-6427 IN denotes by
T5718 6428-6435 JJ denotes binding
T5719 6436-6438 TO denotes to
T5720 6439-6443 NNP denotes CD80
T5721 6444-6447 CC denotes and
T5722 6448-6452 NNP denotes CD86
T5723 6453-6457 IN denotes with
T5724 6458-6462 JJ denotes high
T5725 6463-6470 NN denotes avidity
T5726 6471-6472 NNP denotes [
T5727 6472-6474 CD denotes 23
T5728 6474-6475 NNP denotes ]
T5729 6475-6476 . denotes .
T5730 6477-6482 NN denotes IL-10
T5731 6483-6494 RB denotes efficiently
T5732 6495-6501 VBZ denotes blocks
T5733 6502-6505 DT denotes the
T5734 6506-6522 JJ denotes antigen-specific
T5735 6523-6529 NN denotes T-cell
T5736 6530-6538 NN denotes cytokine
T5737 6539-6547 NN denotes response
T5738 6548-6550 IN denotes by
T5739 6551-6561 VBG denotes inhibiting
T5740 6562-6565 DT denotes the
T5741 6566-6570 NNP denotes CD28
T5742 6571-6580 VBG denotes signaling
T5743 6581-6588 NN denotes pathway
T5744 6589-6590 NNP denotes [
T5745 6590-6592 CD denotes 24
T5746 6592-6593 NNP denotes ]
T5747 6593-6594 , denotes ,
T5748 6595-6597 RB denotes as
T5749 6598-6602 RB denotes well
T5750 6603-6605 IN denotes as
T5751 6606-6616 RB denotes indirectly
T5752 6617-6619 IN denotes by
T5753 6620-6634 VBG denotes downregulating
T5754 6635-6638 DT denotes the
T5755 6639-6647 NN denotes function
T5756 6648-6650 IN denotes of
T5757 6651-6669 JJ denotes antigen-presenting
T5758 6670-6675 NNS denotes cells
T5759 6675-6676 . denotes .
T5760 6677-6679 TO denotes To
T5761 6680-6689 VB denotes elucidate
T5762 6690-6693 DT denotes the
T5763 6694-6704 NN denotes resistance
T5764 6705-6707 IN denotes of
T5765 6708-6711 CD denotes CD4
T5766 6711-6712 CD denotes +
T5767 6713-6714 NNP denotes T
T5768 6715-6720 NNS denotes cells
T5769 6721-6723 TO denotes to
T5770 6724-6728 DT denotes this
T5771 6729-6735 JJ denotes direct
T5772 6736-6746 NN denotes inhibition
T5773 6747-6749 IN denotes in
T5774 6750-6752 NNP denotes RA
T5775 6752-6753 , denotes ,
T5776 6754-6756 PRP denotes we
T5777 6757-6769 VBD denotes investigated
T5778 6770-6773 DT denotes the
T5779 6774-6784 NN denotes production
T5780 6785-6787 IN denotes of
T5781 6788-6793 NNP denotes IFN-γ
T5782 6794-6799 IN denotes after
T5783 6800-6803 NNP denotes CD3
T5784 6804-6807 CC denotes and
T5785 6808-6812 NNP denotes CD28
T5786 6813-6826 NN denotes costimulation
T5787 6827-6829 IN denotes in
T5788 6830-6833 DT denotes the
T5789 6834-6842 NN denotes presence
T5790 6843-6845 IN denotes of
T5791 6846-6851 NNP denotes IL-10
T5792 6851-6852 , denotes ,
T5793 6853-6856 DT denotes the
T5794 6857-6866 NN denotes induction
T5795 6867-6869 IN denotes of
T5796 6870-6875 CD denotes STAT1
T5797 6876-6879 CC denotes and
T5798 6880-6885 CD denotes STAT3
T5799 6886-6901 NN denotes phosphorylation
T5800 6902-6904 IN denotes by
T5801 6905-6910 NNP denotes IL-10
T5802 6910-6911 , denotes ,
T5803 6912-6915 CC denotes and
T5804 6916-6919 DT denotes the
T5805 6920-6930 NN denotes expression
T5806 6931-6933 IN denotes of
T5807 6934-6939 CD denotes SOCS1
T5808 6940-6943 CC denotes and
T5809 6944-6949 CD denotes SOCS3
T5810 6950-6954 NNP denotes mRNA
T5811 6955-6957 IN denotes in
T5812 6958-6968 JJ denotes peripheral
T5813 6969-6974 NN denotes blood
T5814 6975-6976 -LRB- denotes (
T5815 6976-6978 NNP denotes PB
T5816 6978-6979 -RRB- denotes )
T5817 6980-6983 NNP denotes CD4
T5818 6983-6984 CD denotes +
T5819 6985-6986 NNP denotes T
T5820 6987-6992 NNS denotes cells
T5821 6993-6997 IN denotes from
T5822 6998-7000 NNP denotes RA
T5823 7001-7009 NNS denotes patients
T5824 7009-7010 . denotes .
T7081 7035-7043 NNS denotes Patients
T7082 7044-7047 CC denotes and
T7083 7048-7055 NNS denotes samples
T7084 7056-7059 DT denotes The
T7085 7060-7065 JJ denotes total
T7086 7066-7073 JJ denotes patient
T7087 7074-7084 NN denotes population
T7088 7085-7094 VBD denotes consisted
T7089 7095-7097 IN denotes of
T7090 7098-7100 CD denotes 32
T7091 7101-7109 NNS denotes patients
T7092 7110-7114 IN denotes with
T7093 7115-7117 NNP denotes RA
T7094 7118-7119 -LRB- denotes (
T7095 7119-7121 CD denotes 25
T7096 7122-7127 NNS denotes women
T7097 7128-7131 CC denotes and
T7098 7132-7137 CD denotes seven
T7099 7138-7141 NNS denotes men
T7100 7141-7142 : denotes ;
T7101 7143-7147 VB denotes mean
T7102 7148-7149 JJ denotes ±
T7103 7150-7158 JJ denotes standard
T7104 7159-7168 NN denotes deviation
T7105 7169-7172 NN denotes age
T7106 7172-7173 , denotes ,
T7107 7174-7178 CD denotes 52.8
T7108 7179-7180 NN denotes ±
T7109 7181-7185 CD denotes 12.4
T7110 7186-7191 NNS denotes years
T7111 7191-7192 -RRB- denotes )
T7112 7193-7202 VBN denotes diagnosed
T7113 7203-7212 VBG denotes according
T7114 7213-7215 TO denotes to
T7115 7216-7219 DT denotes the
T7116 7220-7227 VBN denotes revised
T7117 7228-7232 CD denotes 1987
T7118 7233-7241 NNS denotes criteria
T7119 7242-7244 IN denotes of
T7120 7245-7248 DT denotes the
T7121 7249-7257 JJ denotes American
T7122 7258-7265 NNP denotes College
T7123 7266-7268 IN denotes of
T7124 7269-7281 NNP denotes Rheumatology
T7125 7282-7283 -LRB- denotes (
T7126 7283-7291 RB denotes formally
T7127 7291-7292 , denotes ,
T7128 7293-7296 DT denotes the
T7129 7297-7305 JJ denotes American
T7130 7306-7316 NNP denotes Rheumatism
T7131 7317-7328 NNP denotes Association
T7132 7328-7329 -RRB- denotes )
T7133 7330-7331 NNP denotes [
T7134 7331-7333 CD denotes 25
T7135 7333-7334 NNP denotes ]
T7136 7334-7335 . denotes .
T7137 7336-7339 DT denotes All
T7138 7340-7348 NNS denotes patients
T7139 7349-7353 VBD denotes were
T7140 7354-7363 VBG denotes receiving
T7141 7364-7376 NN denotes prednisolone
T7142 7377-7378 -LRB- denotes (
T7143 7378-7379 CD denotes ≤
T7144 7380-7383 CD denotes 7.5
T7145 7384-7390 NN denotes mg/day
T7146 7390-7391 -RRB- denotes )
T7147 7392-7395 CC denotes and
T7148 7396-7413 JJ denotes disease-modifying
T7149 7414-7427 JJ denotes antirheumatic
T7150 7428-7433 NNS denotes drugs
T7151 7433-7434 . denotes .
T7152 7435-7443 JJ denotes Clinical
T7153 7444-7454 NNS denotes parameters
T7154 7455-7457 IN denotes in
T7155 7458-7461 DT denotes the
T7156 7462-7467 NN denotes study
T7157 7468-7476 NNS denotes patients
T7158 7477-7481 VBD denotes were
T7159 7482-7484 IN denotes as
T7160 7485-7492 VBZ denotes follows
T7161 7493-7494 -LRB- denotes (
T7162 7494-7498 VB denotes mean
T7163 7499-7500 JJ denotes ±
T7164 7501-7509 JJ denotes standard
T7165 7510-7519 NN denotes deviation
T7166 7519-7520 -RRB- denotes )
T7167 7520-7521 : denotes :
T7168 7522-7533 VB denotes erythrocyte
T7169 7534-7547 NN denotes sedimentation
T7170 7548-7552 NN denotes rate
T7171 7552-7553 , denotes ,
T7172 7554-7558 CD denotes 55.9
T7173 7559-7560 CD denotes ±
T7174 7561-7565 CD denotes 35.4
T7175 7566-7573 NN denotes mm/hour
T7176 7573-7574 : denotes ;
T7177 7575-7580 NN denotes serum
T7178 7581-7591 JJ denotes C-reactive
T7179 7592-7599 NN denotes protein
T7180 7600-7601 -LRB- denotes (
T7181 7601-7604 NNP denotes CRP
T7182 7604-7605 -RRB- denotes )
T7183 7606-7611 NN denotes level
T7184 7611-7612 , denotes ,
T7185 7613-7617 CD denotes 32.0
T7186 7618-7619 CD denotes ±
T7187 7620-7624 CD denotes 32.0
T7188 7625-7629 NN denotes mg/l
T7189 7629-7630 : denotes ;
T7190 7631-7634 CC denotes and
T7191 7635-7638 NNP denotes IgM
T7192 7639-7644 NN denotes class
T7193 7645-7655 JJ denotes rheumatoid
T7194 7656-7662 NN denotes factor
T7195 7663-7668 NN denotes titer
T7196 7668-7669 , denotes ,
T7197 7670-7673 CD denotes 142
T7198 7674-7675 NN denotes ±
T7199 7676-7679 CD denotes 158
T7200 7680-7684 NNP denotes U/ml
T7201 7684-7685 . denotes .
T7202 7686-7694 NNS denotes Patients
T7203 7695-7699 VBD denotes were
T7204 7700-7707 VBN denotes divided
T7205 7708-7712 IN denotes into
T7206 7713-7716 CD denotes two
T7207 7717-7723 NNS denotes groups
T7208 7723-7724 : denotes :
T7209 7725-7727 CD denotes 24
T7210 7728-7736 NNS denotes patients
T7211 7737-7741 IN denotes with
T7212 7742-7748 JJ denotes active
T7213 7749-7756 NN denotes disease
T7214 7756-7757 , denotes ,
T7215 7758-7761 WP denotes who
T7216 7762-7765 VBD denotes had
T7217 7766-7774 JJ denotes multiple
T7218 7775-7781 NN denotes tender
T7219 7782-7788 CC denotes and/or
T7220 7789-7796 JJ denotes swollen
T7221 7797-7803 NNS denotes joints
T7222 7804-7807 CC denotes and
T7223 7808-7816 JJ denotes elevated
T7224 7817-7822 NN denotes serum
T7225 7823-7826 NNP denotes CRP
T7226 7827-7832 NN denotes level
T7227 7833-7834 -LRB- denotes (
T7228 7834-7835 FW denotes ≥
T7229 7836-7838 CD denotes 10
T7230 7839-7843 NN denotes mg/l
T7231 7843-7844 -RRB- denotes )
T7232 7844-7845 : denotes ;
T7233 7846-7849 CC denotes and
T7234 7850-7855 CD denotes eight
T7235 7856-7864 NNS denotes patients
T7236 7865-7869 IN denotes with
T7237 7870-7878 JJ denotes inactive
T7238 7879-7886 NN denotes disease
T7239 7886-7887 , denotes ,
T7240 7888-7891 WP denotes who
T7241 7892-7901 VBD denotes satisfied
T7242 7902-7905 DT denotes the
T7243 7906-7914 JJ denotes American
T7244 7915-7922 NNP denotes College
T7245 7923-7925 IN denotes of
T7246 7926-7938 NNP denotes Rheumatology
T7247 7939-7950 JJ denotes preliminary
T7248 7951-7959 NNS denotes criteria
T7249 7960-7963 IN denotes for
T7250 7964-7972 JJ denotes clinical
T7251 7973-7982 NN denotes remission
T7252 7983-7984 NNP denotes [
T7253 7984-7986 CD denotes 26
T7254 7986-7987 NNP denotes ]
T7255 7987-7988 . denotes .
T7256 7989-7996 CD denotes Sixteen
T7257 7997-8004 JJ denotes healthy
T7258 8005-8015 NNS denotes volunteers
T7259 8016-8017 -LRB- denotes (
T7260 8017-8019 CD denotes 11
T7261 8020-8025 NNS denotes women
T7262 8026-8029 CC denotes and
T7263 8030-8034 CD denotes five
T7264 8035-8038 NNS denotes men
T7265 8038-8039 : denotes ;
T7266 8040-8043 NN denotes age
T7267 8043-8044 , denotes ,
T7268 8045-8049 CD denotes 45.8
T7269 8050-8051 NN denotes ±
T7270 8052-8056 CD denotes 11.2
T7271 8057-8062 NNS denotes years
T7272 8062-8063 -RRB- denotes )
T7273 8064-8070 VBD denotes served
T7274 8071-8073 IN denotes as
T7275 8074-8082 NNS denotes controls
T7276 8082-8083 . denotes .
T7277 8084-8086 NNP denotes ST
T7278 8087-8094 NNS denotes samples
T7279 8095-8099 VBD denotes were
T7280 8100-8108 VBN denotes obtained
T7281 8109-8113 IN denotes from
T7282 8114-8119 CD denotes three
T7283 8120-8122 NNP denotes RA
T7284 8123-8131 NNS denotes patients
T7285 8132-8142 VBG denotes undergoing
T7286 8143-8148 JJ denotes total
T7287 8149-8153 NN denotes knee
T7288 8154-8165 NN denotes replacement
T7289 8165-8166 . denotes .
T7290 8167-8170 DT denotes All
T7291 8171-8179 NNS denotes patients
T7292 8180-8184 VBD denotes gave
T7293 8185-8193 VBN denotes informed
T7294 8194-8201 NN denotes consent
T7295 8201-8202 . denotes .
T7707 8204-8213 NN denotes Isolation
T7708 8214-8216 IN denotes of
T7709 8217-8220 CD denotes CD4
T7710 8220-8221 CD denotes +
T7711 8222-8223 NNP denotes T
T7712 8224-8229 NNS denotes cells
T7713 8230-8240 JJ denotes Peripheral
T7714 8241-8246 NN denotes blood
T7715 8247-8258 NN denotes mononuclear
T7716 8259-8264 NNS denotes cells
T7717 8265-8266 -LRB- denotes (
T7718 8266-8270 NNP denotes PBMC
T7719 8270-8271 -RRB- denotes )
T7720 8272-8276 VBD denotes were
T7721 8277-8285 VBN denotes prepared
T7722 8286-8290 IN denotes from
T7723 8291-8302 VBN denotes heparinized
T7724 8303-8308 NN denotes blood
T7725 8309-8316 NNS denotes samples
T7726 8317-8319 IN denotes by
T7727 8320-8334 NN denotes centrifugation
T7728 8335-8339 IN denotes over
T7729 8340-8354 JJ denotes Ficoll-Hypaque
T7730 8355-8362 NN denotes density
T7731 8363-8372 NNS denotes gradients
T7732 8373-8374 -LRB- denotes (
T7733 8374-8383 NNP denotes Pharmacia
T7734 8383-8384 , denotes ,
T7735 8385-8392 NNP denotes Uppsala
T7736 8392-8393 , denotes ,
T7737 8394-8400 NNP denotes Sweden
T7738 8400-8401 -RRB- denotes )
T7739 8401-8402 . denotes .
T7740 8403-8406 CD denotes CD4
T7741 8406-8407 CD denotes +
T7742 8408-8409 NNP denotes T
T7743 8410-8415 NNS denotes cells
T7744 8416-8420 VBD denotes were
T7745 8421-8429 VBN denotes purified
T7746 8430-8434 IN denotes from
T7747 8435-8439 NNP denotes PBMC
T7748 8440-8442 IN denotes by
T7749 8443-8451 JJ denotes positive
T7750 8452-8461 NN denotes selection
T7751 8462-8467 VBG denotes using
T7752 8468-8476 JJ denotes anti-CD4
T7753 8477-8487 JJ denotes mAb-coated
T7754 8488-8496 JJ denotes magnetic
T7755 8497-8502 NNS denotes beads
T7756 8503-8504 -LRB- denotes (
T7757 8504-8512 NNP denotes Miltenyi
T7758 8513-8519 NNP denotes Biotec
T7759 8519-8520 , denotes ,
T7760 8521-8529 NNP denotes Gladbach
T7761 8529-8530 , denotes ,
T7762 8531-8538 NNP denotes Germany
T7763 8538-8539 -RRB- denotes )
T7764 8539-8540 , denotes ,
T7765 8541-8550 VBG denotes according
T7766 8551-8553 TO denotes to
T7767 8554-8557 DT denotes the
T7768 8558-8570 NN denotes manufacturer
T7769 8570-8572 POS denotes 's
T7770 8573-8585 NNS denotes instructions
T7771 8585-8586 . denotes .
T7772 8587-8590 CD denotes CD4
T7773 8590-8591 CD denotes +
T7774 8592-8593 NNP denotes T
T7775 8594-8599 NNS denotes cells
T7776 8600-8604 VBD denotes were
T7777 8605-8613 VBN denotes isolated
T7778 8614-8618 IN denotes from
T7779 8619-8621 NNP denotes ST
T7780 8622-8629 NNS denotes samples
T7781 8629-8630 , denotes ,
T7782 8631-8633 IN denotes as
T7783 8634-8644 RB denotes previously
T7784 8645-8654 VBN denotes described
T7785 8655-8656 NNP denotes [
T7786 8656-8658 CD denotes 27
T7787 8658-8659 NNP denotes ]
T7788 8659-8660 . denotes .
T7789 8661-8668 RB denotes Briefly
T7790 8668-8669 , denotes ,
T7791 8670-8675 JJ denotes fresh
T7792 8676-8678 NNP denotes ST
T7793 8679-8686 NNS denotes samples
T7794 8687-8691 VBD denotes were
T7795 8692-8702 VBN denotes fragmented
T7796 8703-8706 CC denotes and
T7797 8707-8715 VBN denotes digested
T7798 8716-8720 IN denotes with
T7799 8721-8732 NN denotes collagenase
T7800 8733-8736 CC denotes and
T7801 8737-8742 NNP denotes DNase
T7802 8743-8746 IN denotes for
T7803 8747-8748 CD denotes 1
T7804 8749-8753 NN denotes hour
T7805 8754-8756 IN denotes at
T7806 8757-8759 CD denotes 37
T7807 8759-8760 CD denotes °
T7808 8760-8761 NNP denotes C
T7809 8761-8762 . denotes .
T7810 8763-8768 IN denotes After
T7811 8769-8777 VBG denotes removing
T7812 8778-8784 NN denotes tissue
T7813 8785-8791 NN denotes debris
T7814 8791-8792 , denotes ,
T7815 8793-8795 NNP denotes ST
T7816 8796-8800 NN denotes cell
T7817 8801-8812 NNS denotes suspensions
T7818 8813-8815 IN denotes in
T7819 8816-8823 NN denotes culture
T7820 8824-8830 NN denotes medium
T7821 8831-8832 -LRB- denotes (
T7822 8832-8836 NNP denotes RPMI
T7823 8837-8841 CD denotes 1640
T7824 8842-8848 NN denotes medium
T7825 8848-8849 : denotes ;
T7826 8850-8854 NNP denotes Life
T7827 8855-8867 NNPS denotes Technologies
T7828 8867-8868 , denotes ,
T7829 8869-8881 NNP denotes Gaithersburg
T7830 8881-8882 , denotes ,
T7831 8883-8885 NNP denotes MD
T7832 8885-8886 , denotes ,
T7833 8887-8890 NNP denotes USA
T7834 8890-8891 -RRB- denotes )
T7835 8892-8904 VBN denotes supplemented
T7836 8905-8909 IN denotes with
T7837 8910-8912 CD denotes 25
T7838 8913-8915 NNP denotes mM
T7839 8916-8921 NNP denotes HEPES
T7840 8922-8923 -LRB- denotes (
T7841 8923-8924 CD denotes 2
T7842 8925-8927 NNP denotes mM
T7843 8928-8939 NNP denotes L-glutamine
T7844 8939-8940 , denotes ,
T7845 8941-8942 CD denotes 2
T7846 8942-8943 NN denotes %
T7847 8944-8956 JJ denotes nonessential
T7848 8957-8962 JJ denotes amino
T7849 8963-8968 NNS denotes acids
T7850 8968-8969 , denotes ,
T7851 8970-8973 CD denotes 100
T7852 8974-8979 NNP denotes IU/ml
T7853 8980-8990 NN denotes penicillin
T7854 8990-8991 , denotes ,
T7855 8992-8995 CC denotes and
T7856 8996-8999 CD denotes 100
T7857 9000-9005 JJ denotes mg/ml
T7858 9006-9018 NN denotes streptomycin
T7859 9018-9019 : denotes ;
T7860 9020-9024 NNP denotes Life
T7861 9025-9037 NNPS denotes Technologies
T7862 9037-9038 -RRB- denotes )
T7863 9039-9043 IN denotes with
T7864 9044-9046 CD denotes 10
T7865 9046-9047 NN denotes %
T7866 9048-9064 JJ denotes heat-inactivated
T7867 9065-9068 NNP denotes FCS
T7868 9069-9070 -LRB- denotes (
T7869 9070-9074 NNP denotes Life
T7870 9075-9087 NNPS denotes Technologies
T7871 9087-9088 -RRB- denotes )
T7872 9089-9093 VBD denotes were
T7873 9094-9103 VBN denotes incubated
T7874 9104-9106 IN denotes at
T7875 9107-9109 CD denotes 37
T7876 9109-9110 CD denotes °
T7877 9110-9111 NNP denotes C
T7878 9112-9114 IN denotes in
T7879 9115-9123 JJ denotes six-well
T7880 9124-9130 NNS denotes plates
T7881 9131-9132 -LRB- denotes (
T7882 9132-9138 NNP denotes Coster
T7883 9138-9139 , denotes ,
T7884 9140-9149 NNP denotes Cambridge
T7885 9149-9150 , denotes ,
T7886 9151-9153 NNP denotes MA
T7887 9153-9154 , denotes ,
T7888 9155-9158 NNP denotes USA
T7889 9158-9159 -RRB- denotes )
T7890 9160-9163 IN denotes for
T7891 9164-9166 CD denotes 45
T7892 9167-9170 NN denotes min
T7893 9170-9171 . denotes .
T7894 9172-9184 JJ denotes Non-adherent
T7895 9185-9190 NNS denotes cells
T7896 9191-9195 VBD denotes were
T7897 9196-9205 VBN denotes harvested
T7898 9206-9209 CC denotes and
T7899 9210-9213 NNP denotes CD4
T7900 9213-9214 CD denotes +
T7901 9215-9216 NNP denotes T
T7902 9217-9222 NNS denotes cells
T7903 9223-9227 VBD denotes were
T7904 9228-9236 VBN denotes purified
T7905 9237-9239 IN denotes by
T7906 9240-9248 JJ denotes positive
T7907 9249-9258 NN denotes selection
T7908 9259-9261 IN denotes as
T7909 9262-9269 RB denotes already
T7910 9270-9279 VBN denotes described
T7911 9279-9280 . denotes .
T8313 9282-9289 NNP denotes Culture
T8314 9290-9292 IN denotes of
T8315 9293-9296 NNP denotes CD4
T8316 9296-9297 NNP denotes +
T8317 9298-9299 NNP denotes T
T8318 9300-9305 NNS denotes cells
T8319 9306-9308 NNP denotes PB
T8320 9309-9312 NNP denotes CD4
T8321 9312-9313 NNP denotes +
T8322 9314-9320 NNP denotes T-cell
T8323 9321-9332 NNS denotes populations
T8324 9333-9337 VBD denotes were
T8325 9338-9349 VBN denotes resuspended
T8326 9350-9352 IN denotes at
T8327 9353-9354 DT denotes a
T8328 9355-9362 NN denotes density
T8329 9363-9365 IN denotes of
T8330 9366-9367 CD denotes 1
T8331 9368-9369 CD denotes ×
T8332 9370-9373 CD denotes 106
T8333 9374-9382 NN denotes cells/ml
T8334 9383-9385 IN denotes in
T8335 9386-9393 NN denotes culture
T8336 9394-9400 NN denotes medium
T8337 9401-9405 IN denotes with
T8338 9406-9408 CD denotes 10
T8339 9408-9409 NN denotes %
T8340 9410-9413 NNP denotes FCS
T8341 9413-9414 , denotes ,
T8342 9415-9418 CC denotes and
T8343 9419-9422 CD denotes 0.5
T8344 9423-9425 NN denotes ml
T8345 9426-9430 NN denotes cell
T8346 9431-9442 NNS denotes suspensions
T8347 9443-9447 VBD denotes were
T8348 9448-9457 VBN denotes dispensed
T8349 9458-9462 IN denotes into
T8350 9463-9466 DT denotes the
T8351 9467-9472 NNS denotes wells
T8352 9473-9475 IN denotes of
T8353 9476-9483 JJ denotes 24-well
T8354 9484-9494 NN denotes microtiter
T8355 9495-9501 NNS denotes plates
T8356 9502-9503 -LRB- denotes (
T8357 9503-9509 NNP denotes Coster
T8358 9509-9510 -RRB- denotes )
T8359 9511-9517 VBN denotes coated
T8360 9518-9522 IN denotes with
T8361 9523-9524 CD denotes 1
T8362 9525-9527 NN denotes μg
T8363 9527-9528 NN denotes /
T8364 9528-9530 NN denotes ml
T8365 9531-9539 JJ denotes anti-CD3
T8366 9540-9543 NNP denotes mAb
T8367 9544-9545 -LRB- denotes (
T8368 9545-9555 NNP denotes Immunotech
T8369 9555-9556 , denotes ,
T8370 9557-9566 NNP denotes Marseille
T8371 9566-9567 , denotes ,
T8372 9568-9574 NNP denotes France
T8373 9574-9575 -RRB- denotes )
T8374 9575-9576 . denotes .
T8375 9577-9580 DT denotes The
T8376 9581-9586 NNS denotes cells
T8377 9587-9591 VBD denotes were
T8378 9592-9601 VBN denotes incubated
T8379 9602-9606 IN denotes with
T8380 9607-9608 CD denotes 1
T8381 9609-9611 NN denotes μg
T8382 9611-9612 NN denotes /
T8383 9612-9614 NN denotes ml
T8384 9615-9624 JJ denotes anti-CD28
T8385 9625-9628 NNP denotes mAb
T8386 9629-9630 -LRB- denotes (
T8387 9630-9640 NNP denotes Immunotech
T8388 9640-9641 -RRB- denotes )
T8389 9642-9644 IN denotes in
T8390 9645-9648 DT denotes the
T8391 9649-9657 NN denotes presence
T8392 9658-9660 CC denotes or
T8393 9661-9668 NN denotes absence
T8394 9669-9671 IN denotes of
T8395 9672-9675 DT denotes the
T8396 9676-9685 VBN denotes indicated
T8397 9686-9700 NNS denotes concentrations
T8398 9701-9703 IN denotes of
T8399 9704-9709 NNP denotes IL-10
T8400 9710-9711 -LRB- denotes (
T8401 9711-9717 NNP denotes Becton
T8402 9718-9727 NNP denotes Dickinson
T8403 9727-9728 , denotes ,
T8404 9729-9732 NNP denotes San
T8405 9733-9737 NNP denotes Jose
T8406 9737-9738 , denotes ,
T8407 9739-9741 NNP denotes CA
T8408 9741-9742 , denotes ,
T8409 9743-9746 NNP denotes USA
T8410 9746-9747 -RRB- denotes )
T8411 9748-9750 IN denotes at
T8412 9751-9753 CD denotes 37
T8413 9753-9754 CD denotes °
T8414 9754-9755 NNP denotes C
T8415 9756-9758 IN denotes in
T8416 9759-9760 DT denotes a
T8417 9761-9771 JJ denotes humidified
T8418 9772-9782 NN denotes atmosphere
T8419 9783-9793 VBG denotes containing
T8420 9794-9795 CD denotes 5
T8421 9795-9796 NN denotes %
T8422 9797-9800 CD denotes CO2
T8423 9801-9802 NNP denotes [
T8424 9802-9804 CD denotes 28
T8425 9804-9805 NNP denotes ]
T8426 9805-9806 . denotes .
T8427 9807-9814 NNP denotes Culture
T8428 9815-9827 NNS denotes supernatants
T8429 9828-9832 VBD denotes were
T8430 9833-9842 VBN denotes collected
T8431 9843-9845 CD denotes 36
T8432 9846-9851 NNS denotes hours
T8433 9852-9857 RB denotes later
T8434 9858-9861 CC denotes and
T8435 9862-9871 JJ denotes cell-free
T8436 9872-9879 NNS denotes samples
T8437 9880-9884 VBD denotes were
T8438 9885-9891 VBN denotes stored
T8439 9892-9894 IN denotes at
T8440 9895-9898 CD denotes -30
T8441 9898-9899 CD denotes °
T8442 9899-9900 NNP denotes C
T8443 9901-9906 IN denotes until
T8444 9907-9915 JJ denotes cytokine
T8445 9916-9921 NN denotes assay
T8446 9921-9922 . denotes .
T8447 9923-9925 TO denotes To
T8448 9926-9933 VB denotes examine
T8449 9934-9937 DT denotes the
T8450 9938-9944 NN denotes effect
T8451 9945-9947 IN denotes of
T8452 9948-9952 NN denotes IL-6
T8453 9953-9955 IN denotes on
T8454 9956-9962 NN denotes T-cell
T8455 9963-9977 NN denotes responsiveness
T8456 9978-9980 TO denotes to
T8457 9981-9986 NNP denotes IL-10
T8458 9986-9987 , denotes ,
T8459 9988-9991 NNP denotes CD4
T8460 9991-9992 NNP denotes +
T8461 9993-9994 NNP denotes T
T8462 9995-10000 NNS denotes cells
T8463 10001-10005 IN denotes from
T8464 10006-10013 JJ denotes healthy
T8465 10014-10022 NNS denotes controls
T8466 10023-10027 VBD denotes were
T8467 10028-10037 VBN denotes incubated
T8468 10038-10040 IN denotes in
T8469 10041-10048 NN denotes culture
T8470 10049-10055 NN denotes medium
T8471 10056-10060 IN denotes with
T8472 10061-10063 CD denotes 10
T8473 10063-10064 NN denotes %
T8474 10065-10068 NNP denotes FCS
T8475 10069-10071 IN denotes in
T8476 10072-10075 DT denotes the
T8477 10076-10084 NN denotes presence
T8478 10085-10087 CC denotes or
T8479 10088-10095 NN denotes absence
T8480 10096-10098 IN denotes of
T8481 10099-10101 CD denotes 10
T8482 10102-10107 NN denotes ng/ml
T8483 10108-10112 NN denotes IL-6
T8484 10113-10114 -LRB- denotes (
T8485 10114-10120 NNP denotes Becton
T8486 10121-10130 NNP denotes Dickinson
T8487 10130-10131 -RRB- denotes )
T8488 10132-10135 IN denotes for
T8489 10136-10138 CD denotes 36
T8490 10139-10144 NNS denotes hours
T8491 10144-10145 . denotes .
T8492 10146-10151 NNS denotes Cells
T8493 10152-10156 VBD denotes were
T8494 10157-10161 RB denotes then
T8495 10162-10172 VBN denotes stimulated
T8496 10173-10176 IN denotes for
T8497 10177-10179 CD denotes 36
T8498 10180-10185 NNS denotes hours
T8499 10186-10190 IN denotes with
T8500 10191-10199 JJ denotes anti-CD3
T8501 10200-10203 NNP denotes mAb
T8502 10204-10207 CC denotes and
T8503 10208-10217 JJ denotes anti-CD28
T8504 10218-10221 NN denotes mAb
T8505 10222-10224 IN denotes in
T8506 10225-10228 DT denotes the
T8507 10229-10237 NN denotes presence
T8508 10238-10240 CC denotes or
T8509 10241-10248 NN denotes absence
T8510 10249-10251 IN denotes of
T8511 10252-10253 CD denotes 1
T8512 10254-10259 NN denotes ng/ml
T8513 10260-10265 NN denotes IL-10
T8514 10265-10266 . denotes .
T8515 10267-10274 NNP denotes Culture
T8516 10275-10287 NNS denotes supernatants
T8517 10288-10292 VBD denotes were
T8518 10293-10301 VBN denotes measured
T8519 10302-10305 IN denotes for
T8520 10306-10311 JJ denotes IFN-γ
T8521 10312-10326 NNS denotes concentrations
T8522 10326-10327 . denotes .
T8847 10329-10333 NN denotes Flow
T8848 10334-10344 JJ denotes cytometric
T8849 10345-10353 NN denotes analysis
T8850 10354-10357 IN denotes for
T8851 10358-10365 NNP denotes IL-10R1
T8852 10366-10376 NN denotes expression
T8853 10377-10378 DT denotes A
T8854 10379-10385 NN denotes sample
T8855 10386-10388 IN denotes of
T8856 10389-10390 CD denotes 5
T8857 10391-10392 CD denotes ×
T8858 10393-10396 CD denotes 105
T8859 10397-10402 NNS denotes cells
T8860 10403-10405 IN denotes of
T8861 10406-10410 NNP denotes PBMC
T8862 10411-10414 VBD denotes was
T8863 10415-10426 VBN denotes resuspended
T8864 10427-10429 IN denotes in
T8865 10430-10433 NNP denotes PBS
T8866 10434-10438 IN denotes with
T8867 10439-10440 CD denotes 1
T8868 10440-10441 NN denotes %
T8869 10442-10445 NNP denotes FCS
T8870 10445-10446 . denotes .
T8871 10447-10451 NNP denotes PBMC
T8872 10452-10456 VBD denotes were
T8873 10457-10466 VBN denotes incubated
T8874 10467-10471 IN denotes with
T8875 10472-10482 VBG denotes saturating
T8876 10483-10497 NNS denotes concentrations
T8877 10498-10500 IN denotes of
T8878 10501-10513 JJ denotes anti-IL-10R1
T8879 10514-10517 NNP denotes mAb
T8880 10518-10519 -LRB- denotes (
T8881 10519-10523 NNP denotes IgG1
T8882 10523-10524 : denotes ;
T8883 10525-10528 NNP denotes R&D
T8884 10529-10536 NNS denotes systems
T8885 10536-10537 , denotes ,
T8886 10538-10549 NNP denotes Minneapolis
T8887 10549-10550 , denotes ,
T8888 10551-10553 NNP denotes MN
T8889 10553-10554 , denotes ,
T8890 10555-10558 NNP denotes USA
T8891 10558-10559 -RRB- denotes )
T8892 10560-10562 CC denotes or
T8893 10563-10567 IN denotes with
T8894 10568-10583 JJ denotes isotype-matched
T8895 10584-10591 NN denotes control
T8896 10592-10595 NNP denotes mAb
T8897 10596-10597 -LRB- denotes (
T8898 10597-10607 NNP denotes Immunotech
T8899 10607-10608 -RRB- denotes )
T8900 10608-10609 , denotes ,
T8901 10610-10618 VBN denotes followed
T8902 10619-10621 IN denotes by
T8903 10622-10632 NN denotes incubation
T8904 10633-10637 IN denotes with
T8905 10638-10653 JJ denotes FITC-conjugated
T8906 10654-10658 NN denotes goat
T8907 10659-10669 JJ denotes anti-mouse
T8908 10670-10674 JJ denotes IgG1
T8909 10675-10685 NN denotes polyclonal
T8910 10686-10694 NN denotes antibody
T8911 10695-10696 -LRB- denotes (
T8912 10696-10701 NNP denotes Santa
T8913 10702-10706 NNP denotes Cruz
T8914 10707-10722 NNPS denotes Biotechnologies
T8915 10722-10723 , denotes ,
T8916 10724-10729 NNP denotes Santa
T8917 10730-10734 NNP denotes Cruz
T8918 10734-10735 , denotes ,
T8919 10736-10738 NNP denotes CA
T8920 10738-10739 , denotes ,
T8921 10740-10743 NNP denotes USA
T8922 10743-10744 -RRB- denotes )
T8923 10744-10745 . denotes .
T8924 10746-10751 NNS denotes Cells
T8925 10752-10756 VBD denotes were
T8926 10757-10761 RB denotes then
T8927 10762-10771 VBN denotes incubated
T8928 10772-10776 IN denotes with
T8929 10777-10801 JJ denotes phycoerythrin-conjugated
T8930 10802-10810 JJ denotes anti-CD4
T8931 10811-10814 NNP denotes mAb
T8932 10815-10816 -LRB- denotes (
T8933 10816-10822 NNP denotes Becton
T8934 10823-10832 NNP denotes Dickinson
T8935 10832-10833 -RRB- denotes )
T8936 10833-10834 . denotes .
T8937 10835-10840 NNS denotes Cells
T8938 10841-10845 VBD denotes were
T8939 10846-10852 VBN denotes washed
T8940 10853-10857 RB denotes well
T8941 10858-10862 IN denotes with
T8942 10863-10864 CD denotes 1
T8943 10864-10865 NN denotes %
T8944 10866-10873 NN denotes FCS/PBS
T8945 10874-10881 IN denotes between
T8946 10882-10893 NNS denotes incubations
T8947 10893-10894 . denotes .
T8948 10895-10903 NN denotes Analysis
T8949 10904-10907 VBD denotes was
T8950 10908-10917 VBN denotes performed
T8951 10918-10920 IN denotes on
T8952 10921-10922 DT denotes a
T8953 10923-10930 JJ denotes FACScan
T8954 10931-10935 NN denotes flow
T8955 10936-10945 NN denotes cytometer
T8956 10946-10947 -LRB- denotes (
T8957 10947-10953 NNP denotes Becton
T8958 10954-10963 NNP denotes Dickinson
T8959 10963-10964 -RRB- denotes )
T8960 10964-10965 . denotes .
T9185 10967-10978 NNP denotes Immunoassay
T9186 10979-10982 IN denotes for
T9187 10983-10988 NNP denotes IFN-γ
T9188 10989-10992 CC denotes and
T9189 10993-10997 NNP denotes IL-2
T9190 10998-11012 NNPS denotes Concentrations
T9191 11013-11015 IN denotes of
T9192 11016-11021 NNP denotes IFN-γ
T9193 11022-11025 CC denotes and
T9194 11026-11030 NNP denotes IL-2
T9195 11031-11033 IN denotes in
T9196 11034-11041 NN denotes culture
T9197 11042-11054 NNS denotes supernatants
T9198 11055-11057 IN denotes of
T9199 11058-11061 NNP denotes CD4
T9200 11061-11062 NNP denotes +
T9201 11063-11064 NNP denotes T
T9202 11065-11070 NNS denotes cells
T9203 11071-11075 VBD denotes were
T9204 11076-11084 VBN denotes measured
T9205 11085-11087 IN denotes in
T9206 11088-11097 VB denotes duplicate
T9207 11098-11100 IN denotes by
T9208 11101-11104 DT denotes the
T9209 11105-11117 JJ denotes quantitative
T9210 11118-11126 NN denotes sandwich
T9211 11127-11132 NNP denotes ELISA
T9212 11133-11138 VBG denotes using
T9213 11139-11156 JJ denotes cytokine-specific
T9214 11157-11164 NN denotes capture
T9215 11165-11169 IN denotes with
T9216 11170-11182 JJ denotes biotinylated
T9217 11183-11192 NN denotes detection
T9218 11193-11196 NNP denotes mAb
T9219 11197-11200 CC denotes and
T9220 11201-11212 JJ denotes recombinant
T9221 11213-11221 NN denotes cytokine
T9222 11222-11230 NNS denotes proteins
T9223 11231-11232 -LRB- denotes (
T9224 11232-11235 DT denotes all
T9225 11236-11240 IN denotes from
T9226 11241-11247 NNP denotes Becton
T9227 11248-11257 NNP denotes Dickinson
T9228 11257-11258 -RRB- denotes )
T9229 11258-11259 , denotes ,
T9230 11260-11269 VBG denotes according
T9231 11270-11272 TO denotes to
T9232 11273-11276 DT denotes the
T9233 11277-11289 NN denotes manufacturer
T9234 11289-11291 POS denotes 's
T9235 11292-11300 NN denotes protocol
T9236 11300-11301 . denotes .
T9237 11302-11305 DT denotes The
T9238 11306-11315 NN denotes detection
T9239 11316-11322 NNS denotes limits
T9240 11323-11326 IN denotes for
T9241 11327-11332 NNP denotes IFN-γ
T9242 11333-11336 CC denotes and
T9243 11337-11341 NNP denotes IL-2
T9244 11342-11346 VBD denotes were
T9245 11347-11349 CD denotes 15
T9246 11350-11355 NN denotes pg/ml
T9247 11355-11356 . denotes .
T10126 11358-11367 NN denotes Isolation
T10127 11368-11370 IN denotes of
T10128 11371-11375 NNP denotes mRNA
T10129 11376-11379 CC denotes and
T10130 11380-11389 JJ denotes real-time
T10131 11390-11393 NNP denotes PCR
T10132 11394-11399 NNP denotes Total
T10133 11400-11408 JJ denotes cellular
T10134 11409-11412 NNP denotes RNA
T10135 11413-11416 VBD denotes was
T10136 11417-11426 VBN denotes extracted
T10137 11427-11431 IN denotes from
T10138 11432-11434 NNP denotes PB
T10139 11435-11438 NNP denotes CD4
T10140 11438-11439 VBD denotes +
T10141 11440-11441 NNP denotes T
T10142 11442-11447 NNS denotes cells
T10143 11448-11453 VBG denotes using
T10144 11454-11456 DT denotes an
T10145 11457-11460 NNP denotes RNA
T10146 11461-11470 NN denotes isolation
T10147 11471-11474 NN denotes kit
T10148 11475-11476 -LRB- denotes (
T10149 11476-11482 NNP denotes RNeasy
T10150 11483-11487 NNP denotes Mini
T10151 11488-11491 NN denotes kit
T10152 11491-11492 : denotes ;
T10153 11493-11499 NNP denotes Qiagen
T10154 11499-11500 , denotes ,
T10155 11501-11509 NNP denotes Valencia
T10156 11509-11510 , denotes ,
T10157 11511-11513 NNP denotes CA
T10158 11513-11514 , denotes ,
T10159 11515-11518 NNP denotes USA
T10160 11518-11519 -RRB- denotes )
T10161 11519-11520 , denotes ,
T10162 11521-11530 VBG denotes according
T10163 11531-11533 TO denotes to
T10164 11534-11537 DT denotes the
T10165 11538-11550 NN denotes manufacturer
T10166 11550-11552 POS denotes 's
T10167 11553-11565 NNS denotes instructions
T10168 11565-11566 . denotes .
T10169 11567-11571 NNP denotes cDNA
T10170 11572-11575 VBD denotes was
T10171 11576-11587 VBN denotes synthesized
T10172 11588-11592 IN denotes from
T10173 11593-11598 JJ denotes total
T10174 11599-11602 NNP denotes RNA
T10175 11603-11607 IN denotes with
T10176 11608-11614 NNP denotes Molony
T10177 11615-11621 NN denotes murine
T10178 11622-11630 NN denotes leukemia
T10179 11631-11636 NN denotes virus
T10180 11637-11644 VB denotes reverse
T10181 11645-11658 NN denotes transcriptase
T10182 11659-11660 -LRB- denotes (
T10183 11660-11662 NNP denotes US
T10184 11663-11674 NNP denotes Biochemical
T10185 11674-11675 , denotes ,
T10186 11676-11685 NNP denotes Cleveland
T10187 11685-11686 , denotes ,
T10188 11687-11689 NNP denotes OH
T10189 11689-11690 , denotes ,
T10190 11691-11694 NNP denotes USA
T10191 11694-11695 -RRB- denotes )
T10192 11696-11699 CC denotes and
T10193 11700-11705 SYM denotes oligo
T10194 11705-11706 : denotes -
T10195 11706-11707 -LRB- denotes (
T10196 11707-11709 NN denotes dT
T10197 11709-11710 -RRB- denotes )
T10198 11710-11712 CD denotes 15
T10199 11713-11720 NNS denotes primers
T10200 11721-11722 -LRB- denotes (
T10201 11722-11729 NNP denotes Promega
T10202 11729-11730 , denotes ,
T10203 11731-11738 NNP denotes Madison
T10204 11738-11739 , denotes ,
T10205 11740-11742 NNP denotes WI
T10206 11742-11743 , denotes ,
T10207 11744-11747 NNP denotes USA
T10208 11747-11748 -RRB- denotes )
T10209 11748-11749 . denotes .
T10210 11750-11759 JJ denotes Real-time
T10211 11760-11763 NNP denotes PCR
T10212 11764-11767 VBD denotes was
T10213 11768-11777 VBN denotes performed
T10214 11778-11782 IN denotes with
T10215 11783-11786 DT denotes the
T10216 11787-11798 NNP denotes LightCycler
T10217 11799-11809 NNP denotes Instrument
T10218 11810-11811 -LRB- denotes (
T10219 11811-11816 NNP denotes Roche
T10220 11817-11828 NNPS denotes Diagnostics
T10221 11828-11829 , denotes ,
T10222 11830-11838 NNP denotes Penzberg
T10223 11838-11839 , denotes ,
T10224 11840-11847 NNP denotes Germany
T10225 11847-11848 -RRB- denotes )
T10226 11849-11851 IN denotes in
T10227 11852-11857 NN denotes glass
T10228 11858-11869 NNS denotes capillaries
T10229 11869-11870 . denotes .
T10230 11871-11874 DT denotes The
T10231 11875-11883 NN denotes reaction
T10232 11884-11887 NN denotes mix
T10233 11888-11898 VBG denotes containing
T10234 11899-11902 NNP denotes Taq
T10235 11903-11906 NNP denotes DNA
T10236 11907-11917 NN denotes polymerase
T10237 11918-11921 CC denotes and
T10238 11922-11925 NN denotes DNA
T10239 11926-11948 JJ denotes double-strand-specific
T10240 11949-11953 NNP denotes SYBR
T10241 11954-11959 NNP denotes Green
T10242 11960-11961 PRP denotes I
T10243 11962-11965 VBP denotes dye
T10244 11966-11967 -LRB- denotes (
T10245 11967-11978 NNP denotes Lightcycler
T10246 11979-11988 NNP denotes FastStart
T10247 11989-11992 NNP denotes DNA
T10248 11993-11999 NNP denotes Master
T10249 12000-12004 NNP denotes SYBR
T10250 12005-12010 NNP denotes Green
T10251 12011-12012 PRP denotes I
T10252 12012-12013 : denotes ;
T10253 12014-12019 NNP denotes Roche
T10254 12020-12031 NNPS denotes Diagnostics
T10255 12031-12032 -RRB- denotes )
T10256 12033-12036 CC denotes and
T10257 12037-12045 JJ denotes specific
T10258 12046-12053 NNS denotes primers
T10259 12054-12058 VBD denotes were
T10260 12059-12064 VBN denotes added
T10261 12065-12067 TO denotes to
T10262 12068-12072 NNP denotes cDNA
T10263 12073-12082 NNS denotes dilutions
T10264 12082-12083 . denotes .
T10265 12084-12087 DT denotes The
T10266 12088-12092 NNP denotes cDNA
T10267 12093-12100 NNS denotes samples
T10268 12101-12105 VBD denotes were
T10269 12106-12115 VBN denotes denatured
T10270 12116-12118 IN denotes at
T10271 12119-12121 CD denotes 95
T10272 12121-12122 CD denotes °
T10273 12123-12124 NNP denotes C
T10274 12125-12128 IN denotes for
T10275 12129-12131 CD denotes 10
T10276 12132-12135 NN denotes min
T10277 12135-12136 , denotes ,
T10278 12137-12140 CC denotes and
T10279 12141-12145 VBD denotes were
T10280 12146-12150 RB denotes then
T10281 12151-12160 VBN denotes amplified
T10282 12161-12164 IN denotes for
T10283 12165-12167 CD denotes 40
T10284 12168-12170 CD denotes 50
T10285 12171-12177 NNS denotes cycles
T10286 12177-12178 : denotes :
T10287 12179-12181 IN denotes at
T10288 12182-12184 CD denotes 95
T10289 12184-12185 CD denotes °
T10290 12186-12187 NNP denotes C
T10291 12188-12189 -LRB- denotes (
T10292 12189-12191 CD denotes 10
T10293 12192-12193 PRP denotes s
T10294 12193-12194 -RRB- denotes )
T10295 12194-12195 , denotes ,
T10296 12196-12198 IN denotes at
T10297 12199-12201 CD denotes 65
T10298 12201-12202 CD denotes °
T10299 12203-12204 NNP denotes C
T10300 12205-12206 -LRB- denotes (
T10301 12206-12208 CD denotes 15
T10302 12209-12210 PRP denotes s
T10303 12210-12211 -RRB- denotes )
T10304 12211-12212 , denotes ,
T10305 12213-12216 CC denotes and
T10306 12217-12219 CD denotes 72
T10307 12219-12220 NN denotes °
T10308 12221-12222 NNP denotes C
T10309 12223-12224 -LRB- denotes (
T10310 12224-12226 CD denotes 22
T10311 12227-12228 PRP denotes s
T10312 12228-12229 -RRB- denotes )
T10313 12230-12233 IN denotes for
T10314 12234-12241 NN denotes β-actin
T10315 12241-12242 : denotes ;
T10316 12243-12245 IN denotes at
T10317 12246-12248 CD denotes 95
T10318 12248-12249 CD denotes °
T10319 12250-12251 NNP denotes C
T10320 12252-12253 -LRB- denotes (
T10321 12253-12255 CD denotes 10
T10322 12256-12257 PRP denotes s
T10323 12257-12258 -RRB- denotes )
T10324 12258-12259 , denotes ,
T10325 12260-12262 IN denotes at
T10326 12263-12265 CD denotes 62
T10327 12265-12266 CD denotes °
T10328 12267-12268 NNP denotes C
T10329 12269-12270 -LRB- denotes (
T10330 12270-12272 CD denotes 15
T10331 12273-12274 PRP denotes s
T10332 12274-12275 -RRB- denotes )
T10333 12275-12276 , denotes ,
T10334 12277-12280 CC denotes and
T10335 12281-12283 IN denotes at
T10336 12284-12286 CD denotes 72
T10337 12286-12287 CD denotes °
T10338 12288-12289 NNP denotes C
T10339 12290-12291 -LRB- denotes (
T10340 12291-12293 CD denotes 10
T10341 12294-12295 PRP denotes s
T10342 12295-12296 -RRB- denotes )
T10343 12297-12300 IN denotes for
T10344 12301-12306 CD denotes SOCS1
T10345 12306-12307 : denotes ;
T10346 12308-12311 CC denotes and
T10347 12312-12314 IN denotes at
T10348 12315-12317 CD denotes 96
T10349 12317-12318 CD denotes °
T10350 12319-12320 NNP denotes C
T10351 12321-12322 -LRB- denotes (
T10352 12322-12324 CD denotes 10
T10353 12325-12326 PRP denotes s
T10354 12326-12327 -RRB- denotes )
T10355 12327-12328 , denotes ,
T10356 12329-12331 IN denotes at
T10357 12332-12334 CD denotes 68
T10358 12334-12335 CD denotes °
T10359 12336-12337 NNP denotes C
T10360 12338-12339 -LRB- denotes (
T10361 12339-12341 CD denotes 15
T10362 12342-12343 PRP denotes s
T10363 12343-12344 -RRB- denotes )
T10364 12344-12345 , denotes ,
T10365 12346-12349 CC denotes and
T10366 12350-12352 IN denotes at
T10367 12353-12355 CD denotes 72
T10368 12355-12356 CD denotes °
T10369 12357-12358 NNP denotes C
T10370 12359-12360 -LRB- denotes (
T10371 12360-12362 CD denotes 15
T10372 12363-12364 PRP denotes s
T10373 12364-12365 -RRB- denotes )
T10374 12366-12369 IN denotes for
T10375 12370-12375 NNP denotes SOCS3
T10376 12375-12376 . denotes .
T10377 12377-12390 NNP denotes Amplification
T10378 12391-12397 NNS denotes curves
T10379 12398-12400 IN denotes of
T10380 12401-12404 DT denotes the
T10381 12405-12417 NN denotes fluorescence
T10382 12418-12424 NNS denotes values
T10383 12425-12431 CC denotes versus
T10384 12432-12437 NN denotes cycle
T10385 12438-12444 NN denotes number
T10386 12445-12449 VBD denotes were
T10387 12450-12458 VBN denotes obtained
T10388 12458-12459 , denotes ,
T10389 12460-12463 CC denotes and
T10390 12464-12465 DT denotes a
T10391 12466-12473 NN denotes melting
T10392 12474-12479 NN denotes curve
T10393 12480-12488 NN denotes analysis
T10394 12489-12492 VBD denotes was
T10395 12493-12497 RB denotes then
T10396 12498-12507 VBN denotes performed
T10397 12507-12508 . denotes .
T10398 12509-12512 DT denotes The
T10399 12513-12519 NNS denotes levels
T10400 12520-12522 IN denotes of
T10401 12523-12528 CD denotes SOCS1
T10402 12529-12532 CC denotes and
T10403 12533-12538 CD denotes SOCS3
T10404 12539-12549 NN denotes expression
T10405 12550-12554 VBD denotes were
T10406 12555-12565 VBN denotes determined
T10407 12566-12568 IN denotes by
T10408 12569-12580 VBG denotes normalizing
T10409 12581-12589 JJ denotes relative
T10410 12590-12592 TO denotes to
T10411 12593-12600 VB denotes β-actin
T10412 12601-12611 NN denotes expression
T10413 12611-12612 . denotes .
T10414 12613-12616 DT denotes The
T10415 12617-12624 JJ denotes forward
T10416 12625-12628 CC denotes and
T10417 12629-12636 VB denotes reverse
T10418 12637-12644 NNS denotes primers
T10419 12645-12649 VBD denotes were
T10420 12650-12652 IN denotes as
T10421 12653-12660 VBZ denotes follows
T10422 12660-12661 : denotes :
T10423 12662-12665 IN denotes for
T10424 12666-12673 NN denotes β-actin
T10425 12673-12674 , denotes ,
T10426 12675-12676 CD denotes 5
T10427 12676-12677 '' denotes '
T10428 12677-12678 : denotes -
T10429 12678-12700 NN denotes GTGGGGCGCCCCAGGCACCA-3
T10430 12700-12701 '' denotes '
T10431 12702-12705 CC denotes and
T10432 12706-12707 CD denotes 5
T10433 12707-12708 '' denotes '
T10434 12708-12709 : denotes -
T10435 12709-12735 NN denotes CTCCTTAATGTCACGCACGATTTC-3
T10436 12735-12736 '' denotes '
T10437 12737-12738 : denotes ;
T10438 12739-12742 IN denotes for
T10439 12743-12748 NNP denotes SOCS1
T10440 12748-12749 , denotes ,
T10441 12750-12751 CD denotes 5
T10442 12751-12752 '' denotes '
T10443 12752-12753 : denotes -
T10444 12753-12775 NN denotes AGACCCCTTCTCACCTCTTG-3
T10445 12775-12776 '' denotes '
T10446 12777-12780 CC denotes and
T10447 12781-12782 CD denotes 5
T10448 12782-12783 '' denotes '
T10449 12783-12784 : denotes -
T10450 12784-12806 NN denotes GCACAGCAGAAAAATAAAGC-3
T10451 12806-12807 '' denotes '
T10452 12808-12809 : denotes ;
T10453 12810-12813 CC denotes and
T10454 12814-12817 IN denotes for
T10455 12818-12823 NNP denotes SOCS3
T10456 12823-12824 , denotes ,
T10457 12825-12826 CD denotes 5
T10458 12826-12827 '' denotes '
T10459 12827-12828 : denotes -
T10460 12828-12848 NN denotes CCCGCCGGCACCTTTCTG-3
T10461 12848-12849 '' denotes '
T10462 12850-12853 CC denotes and
T10463 12854-12855 CD denotes 5
T10464 12855-12856 '' denotes '
T10465 12856-12857 : denotes -
T10466 12857-12877 NN denotes AGGGGCCGGCTCAACACC-3
T10467 12877-12878 '' denotes '
T10468 12878-12879 . denotes .
T11423 12881-12888 JJ denotes Western
T11424 12889-12893 NN denotes blot
T11425 12894-12902 NN denotes analysis
T11426 12903-12906 NNP denotes CD4
T11427 12906-12907 NNP denotes +
T11428 12908-12909 NNP denotes T
T11429 12910-12915 NNS denotes cells
T11430 12916-12920 VBD denotes were
T11431 12921-12931 VBN denotes stimulated
T11432 12932-12935 IN denotes for
T11433 12936-12938 CD denotes 20
T11434 12939-12942 NN denotes min
T11435 12943-12945 IN denotes by
T11436 12946-12949 DT denotes the
T11437 12950-12959 VBN denotes indicated
T11438 12960-12974 NNS denotes concentrations
T11439 12975-12977 IN denotes of
T11440 12978-12983 NN denotes IL-10
T11441 12984-12987 CC denotes and
T11442 12988-12992 NN denotes IL-6
T11443 12993-12995 IN denotes at
T11444 12996-12997 DT denotes a
T11445 12998-13005 NN denotes density
T11446 13006-13008 IN denotes of
T11447 13009-13010 CD denotes 5
T11448 13011-13012 CD denotes ×
T11449 13013-13016 CD denotes 105
T11450 13017-13022 NNS denotes cells
T11451 13023-13025 IN denotes in
T11452 13026-13029 CD denotes 0.5
T11453 13030-13032 JJ denotes ml
T11454 13033-13040 NN denotes culture
T11455 13041-13047 NN denotes medium
T11456 13048-13052 IN denotes with
T11457 13053-13055 CD denotes 10
T11458 13055-13056 NN denotes %
T11459 13057-13060 NNP denotes FCS
T11460 13060-13061 . denotes .
T11461 13062-13064 TO denotes To
T11462 13065-13072 VB denotes examine
T11463 13073-13076 DT denotes the
T11464 13077-13083 NN denotes effect
T11465 13084-13086 IN denotes of
T11466 13087-13092 NN denotes serum
T11467 13093-13097 NN denotes IL-6
T11468 13098-13100 IN denotes on
T11469 13101-13105 NNP denotes STAT
T11470 13106-13121 NN denotes phosphorylation
T11471 13121-13122 , denotes ,
T11472 13123-13129 JJ denotes normal
T11473 13130-13133 NNP denotes CD4
T11474 13133-13134 CD denotes +
T11475 13135-13136 NNP denotes T
T11476 13137-13142 NNS denotes cells
T11477 13143-13147 VBD denotes were
T11478 13148-13158 VBN denotes stimulated
T11479 13159-13162 IN denotes for
T11480 13163-13165 CD denotes 20
T11481 13166-13169 NN denotes min
T11482 13170-13174 IN denotes with
T11483 13175-13177 CD denotes 30
T11484 13177-13178 NN denotes %
T11485 13179-13185 JJ denotes active
T11486 13186-13188 NNP denotes RA
T11487 13189-13194 NN denotes serum
T11488 13195-13197 IN denotes in
T11489 13198-13205 NN denotes culture
T11490 13206-13212 NN denotes medium
T11491 13213-13217 IN denotes with
T11492 13218-13220 CD denotes 40
T11493 13221-13223 NN denotes μg
T11494 13223-13224 NN denotes /
T11495 13224-13226 NN denotes ml
T11496 13227-13239 VBG denotes neutralizing
T11497 13240-13244 NN denotes goat
T11498 13245-13254 JJ denotes anti-IL-6
T11499 13255-13265 JJ denotes polyclonal
T11500 13266-13274 NN denotes antibody
T11501 13275-13276 -LRB- denotes (
T11502 13276-13279 NNP denotes IgG
T11503 13279-13280 : denotes ;
T11504 13281-13287 NNP denotes Techne
T11505 13287-13288 , denotes ,
T11506 13289-13298 NNP denotes Princeton
T11507 13298-13299 , denotes ,
T11508 13300-13302 NNP denotes NJ
T11509 13302-13303 , denotes ,
T11510 13304-13307 NNP denotes USA
T11511 13307-13308 -RRB- denotes )
T11512 13309-13311 CC denotes or
T11513 13312-13319 VB denotes control
T11514 13320-13324 JJ denotes goat
T11515 13325-13328 NNP denotes IgG
T11516 13329-13330 -LRB- denotes (
T11517 13330-13336 NNP denotes Techne
T11518 13336-13337 -RRB- denotes )
T11519 13337-13338 . denotes .
T11520 13339-13344 JJ denotes Whole
T11521 13345-13349 NN denotes cell
T11522 13350-13357 NNS denotes lysates
T11523 13358-13362 VBD denotes were
T11524 13363-13371 VBN denotes prepared
T11525 13372-13374 IN denotes by
T11526 13375-13382 VBG denotes placing
T11527 13383-13388 NNS denotes cells
T11528 13389-13391 IN denotes in
T11529 13392-13395 CD denotes 100
T11530 13396-13398 NN denotes μl
T11531 13399-13402 NNP denotes SDS
T11532 13403-13409 VBG denotes lysing
T11533 13410-13416 NN denotes buffer
T11534 13417-13418 -LRB- denotes (
T11535 13418-13422 CD denotes 62.5
T11536 13423-13425 NNP denotes mM
T11537 13426-13430 NNP denotes Tris
T11538 13431-13434 NNP denotes HCl
T11539 13435-13436 NNP denotes [
T11540 13436-13438 NNP denotes pH
T11541 13439-13442 CD denotes 6.8
T11542 13442-13443 NNP denotes ]
T11543 13443-13444 , denotes ,
T11544 13445-13446 CD denotes 2
T11545 13446-13447 NN denotes %
T11546 13448-13451 NNP denotes SDS
T11547 13451-13452 , denotes ,
T11548 13453-13455 CD denotes 10
T11549 13455-13456 NN denotes %
T11550 13457-13465 NN denotes glycerol
T11551 13465-13466 , denotes ,
T11552 13467-13469 CD denotes 50
T11553 13470-13472 NN denotes mM
T11554 13473-13487 NN denotes dithiothreitol
T11555 13487-13488 , denotes ,
T11556 13489-13492 CD denotes 0.1
T11557 13492-13493 NN denotes %
T11558 13494-13504 NN denotes bromphenol
T11559 13505-13509 JJ denotes blue
T11560 13509-13510 -RRB- denotes )
T11561 13510-13511 . denotes .
T11562 13512-13516 RB denotes Then
T11563 13517-13519 CD denotes 20
T11564 13520-13522 NN denotes μl
T11565 13523-13530 NN denotes protein
T11566 13531-13538 NNS denotes samples
T11567 13539-13543 VBD denotes were
T11568 13544-13556 VBN denotes fractionated
T11569 13557-13559 IN denotes on
T11570 13560-13562 CD denotes 10
T11571 13562-13563 NN denotes %
T11572 13564-13582 JJ denotes SDS-polyacrylamide
T11573 13583-13587 NNS denotes gels
T11574 13588-13591 CC denotes and
T11575 13592-13596 VBD denotes were
T11576 13597-13608 VBN denotes transferred
T11577 13609-13611 TO denotes to
T11578 13612-13626 JJ denotes nitrocellulose
T11579 13627-13636 NNS denotes membranes
T11580 13637-13638 -LRB- denotes (
T11581 13638-13646 NNP denotes Amersham
T11582 13646-13647 , denotes ,
T11583 13648-13663 NNP denotes Buckinghamshire
T11584 13663-13664 , denotes ,
T11585 13665-13667 NNP denotes UK
T11586 13667-13668 -RRB- denotes )
T11587 13668-13669 , denotes ,
T11588 13670-13673 CC denotes and
T11589 13674-13677 DT denotes the
T11590 13678-13686 NN denotes membrane
T11591 13687-13690 VBD denotes was
T11592 13691-13698 VBN denotes blocked
T11593 13699-13703 IN denotes with
T11594 13704-13705 CD denotes 5
T11595 13705-13706 NN denotes %
T11596 13707-13711 VBP denotes skim
T11597 13712-13716 NN denotes milk
T11598 13717-13719 IN denotes in
T11599 13720-13733 JJ denotes Tris-buffered
T11600 13734-13740 NN denotes saline
T11601 13741-13745 IN denotes with
T11602 13746-13749 CD denotes 0.1
T11603 13749-13750 NN denotes %
T11604 13751-13756 CD denotes Tween
T11605 13757-13759 CD denotes 20
T11606 13759-13760 . denotes .
T11607 13761-13769 NNP denotes Tyrosine
T11608 13770-13785 NN denotes phosphorylation
T11609 13786-13788 IN denotes of
T11610 13789-13794 CD denotes STAT1
T11611 13795-13798 CC denotes and
T11612 13799-13804 CD denotes STAT3
T11613 13805-13808 VBD denotes was
T11614 13809-13817 VBN denotes detected
T11615 13818-13823 VBG denotes using
T11616 13824-13834 JJ denotes commercial
T11617 13835-13844 JJ denotes available
T11618 13845-13849 NNS denotes kits
T11619 13850-13851 -LRB- denotes (
T11620 13851-13855 NNP denotes Cell
T11621 13856-13865 NNP denotes Signaling
T11622 13866-13876 NNP denotes Technology
T11623 13876-13877 , denotes ,
T11624 13878-13885 NNP denotes Beverly
T11625 13885-13886 , denotes ,
T11626 13887-13889 NNP denotes MA
T11627 13889-13890 , denotes ,
T11628 13891-13894 NNP denotes USA
T11629 13894-13895 -RRB- denotes )
T11630 13896-13905 VBG denotes according
T11631 13906-13908 TO denotes to
T11632 13909-13912 DT denotes the
T11633 13913-13925 NN denotes manufacturer
T11634 13925-13927 POS denotes 's
T11635 13928-13940 NNS denotes instructions
T11636 13940-13941 . denotes .
T11637 13942-13949 RB denotes Briefly
T11638 13949-13950 , denotes ,
T11639 13951-13954 DT denotes the
T11640 13955-13963 NN denotes membrane
T11641 13964-13967 VBD denotes was
T11642 13968-13977 VBN denotes incubated
T11643 13978-13982 IN denotes with
T11644 13983-13986 DT denotes the
T11645 13987-13997 NNS denotes antibodies
T11646 13998-13999 -LRB- denotes (
T11647 13999-14005 NN denotes rabbit
T11648 14006-14009 NNP denotes IgG
T11649 14009-14010 -RRB- denotes )
T11650 14011-14021 JJ denotes anti-STAT1
T11651 14022-14030 NN denotes antibody
T11652 14030-14031 , denotes ,
T11653 14032-14051 JJ denotes anti-phosphorylated
T11654 14052-14060 NN denotes tyrosine
T11655 14061-14064 CD denotes 701
T11656 14065-14067 IN denotes of
T11657 14068-14073 CD denotes STAT1
T11658 14074-14082 NN denotes antibody
T11659 14082-14083 , denotes ,
T11660 14084-14094 JJ denotes anti-STAT3
T11661 14095-14103 NN denotes antibody
T11662 14103-14104 , denotes ,
T11663 14105-14108 CC denotes and
T11664 14109-14128 JJ denotes anti-phosphorylated
T11665 14129-14137 NN denotes tyrosine
T11666 14138-14141 CD denotes 705
T11667 14142-14144 IN denotes of
T11668 14145-14150 CD denotes STAT3
T11669 14151-14159 NN denotes antibody
T11670 14159-14160 , denotes ,
T11671 14161-14168 VBN denotes diluted
T11672 14169-14171 IN denotes as
T11673 14172-14183 VBN denotes recommended
T11674 14184-14186 IN denotes at
T11675 14187-14193 CD denotes 1/2000
T11676 14194-14198 IN denotes with
T11677 14199-14212 JJ denotes Tris-buffered
T11678 14213-14219 NN denotes saline
T11679 14220-14224 IN denotes with
T11680 14225-14228 CD denotes 0.1
T11681 14228-14229 NN denotes %
T11682 14230-14235 CD denotes Tween
T11683 14236-14238 CD denotes 20
T11684 14239-14243 IN denotes with
T11685 14244-14245 CD denotes 5
T11686 14245-14246 NN denotes %
T11687 14247-14250 NNP denotes BSA
T11688 14250-14251 . denotes .
T11689 14252-14260 NN denotes Antibody
T11690 14261-14268 JJ denotes binding
T11691 14269-14272 VBD denotes was
T11692 14273-14281 VBN denotes detected
T11693 14282-14284 IN denotes by
T11694 14285-14296 JJ denotes horseradish
T11695 14297-14318 JJ denotes peroxidase-conjugated
T11696 14319-14330 JJ denotes anti-rabbit
T11697 14331-14334 NNP denotes IgG
T11698 14335-14343 NN denotes antibody
T11699 14344-14351 VBN denotes diluted
T11700 14352-14354 IN denotes at
T11701 14355-14361 CD denotes 1/4000
T11702 14362-14366 IN denotes with
T11703 14367-14380 JJ denotes Tris-buffered
T11704 14381-14387 NN denotes saline
T11705 14388-14392 IN denotes with
T11706 14393-14396 CD denotes 0.1
T11707 14396-14397 NN denotes %
T11708 14398-14403 CD denotes Tween
T11709 14404-14406 CD denotes 20
T11710 14407-14411 IN denotes with
T11711 14412-14413 CD denotes 5
T11712 14413-14414 NN denotes %
T11713 14415-14418 NNP denotes BSA
T11714 14418-14419 , denotes ,
T11715 14420-14423 CC denotes and
T11716 14424-14427 VBD denotes was
T11717 14428-14436 VBN denotes revealed
T11718 14437-14442 VBG denotes using
T11719 14443-14446 DT denotes the
T11720 14447-14464 NN denotes chemiluminescence
T11721 14465-14471 NN denotes system
T11722 14471-14472 . denotes .
T11723 14473-14480 NN denotes Protein
T11724 14481-14486 NNS denotes bands
T11725 14487-14491 VBD denotes were
T11726 14492-14502 VBN denotes quantified
T11727 14503-14505 IN denotes by
T11728 14506-14518 NN denotes densitometry
T11729 14519-14524 VBG denotes using
T11730 14525-14534 JJ denotes NIH-Image
T11731 14535-14543 NN denotes analysis
T11732 14543-14544 , denotes ,
T11733 14545-14548 CC denotes and
T11734 14549-14553 NNP denotes STAT
T11735 14554-14569 NN denotes phosphorylation
T11736 14570-14573 VBD denotes was
T11737 14574-14582 VBN denotes compared
T11738 14583-14587 IN denotes with
T11739 14588-14591 DT denotes the
T11740 14592-14597 JJ denotes total
T11741 14598-14604 NN denotes amount
T11742 14605-14607 IN denotes of
T11743 14608-14612 NNP denotes STAT
T11744 14613-14620 NN denotes protein
T11745 14620-14621 . denotes .
T11746 14622-14638 JJ denotes IFN-γ-stimulated
T11747 14639-14643 NNP denotes Hela
T11748 14644-14649 NNS denotes cells
T11749 14650-14654 VBD denotes were
T11750 14655-14659 VBN denotes used
T11751 14660-14662 IN denotes as
T11752 14663-14664 DT denotes a
T11753 14665-14673 JJ denotes positive
T11754 14674-14681 NN denotes control
T11755 14682-14685 IN denotes for
T11756 14686-14691 CD denotes STAT1
T11757 14692-14708 NN denotes phosophorylation
T11758 14708-14709 . denotes .
T12022 14711-14722 NNP denotes Statistical
T12023 14723-14731 NN denotes analysis
T12024 14732-14736 NNS denotes Data
T12025 14737-14740 VBP denotes are
T12026 14741-14750 VBN denotes expressed
T12027 14751-14753 IN denotes as
T12028 14754-14757 DT denotes the
T12029 14758-14762 JJ denotes mean
T12030 14763-14768 NN denotes value
T12031 14769-14770 NN denotes ±
T12032 14771-14779 JJ denotes standard
T12033 14780-14785 NN denotes error
T12034 14786-14788 IN denotes of
T12035 14789-14792 DT denotes the
T12036 14793-14797 NN denotes mean
T12037 14798-14800 CC denotes or
T12038 14801-14804 NN denotes box
T12039 14805-14810 NNS denotes plots
T12040 14810-14811 . denotes .
T12041 14812-14815 DT denotes The
T12042 14816-14827 JJ denotes statistical
T12043 14828-14840 NN denotes significance
T12044 14841-14843 IN denotes of
T12045 14844-14855 NNS denotes differences
T12046 14856-14863 IN denotes between
T12047 14864-14867 CD denotes two
T12048 14868-14874 NNS denotes groups
T12049 14875-14878 VBD denotes was
T12050 14879-14889 VBN denotes determined
T12051 14890-14892 IN denotes by
T12052 14893-14896 DT denotes the
T12053 14897-14901 NNP denotes Mann
T12054 14902-14909 NNP denotes Whitney
T12055 14910-14911 NNP denotes U
T12056 14912-14916 NN denotes test
T12057 14917-14919 CC denotes or
T12058 14920-14923 DT denotes the
T12059 14924-14932 NNP denotes Wilcoxon
T12060 14933-14939 VBD denotes signed
T12061 14940-14944 JJ denotes rank
T12062 14945-14949 NN denotes test
T12063 14949-14950 . denotes .
T12064 14951-14952 NNP denotes P
T12065 14953-14954 VBD denotes <
T12066 14955-14959 CD denotes 0.05
T12067 14960-14963 VBD denotes was
T12068 14964-14974 VBN denotes considered
T12069 14975-14986 JJ denotes significant
T12070 14986-14987 . denotes .
T13643 14998-15008 NN denotes Resistance
T13644 15009-15011 TO denotes to
T13645 15012-15017 NNP denotes IL-10
T13646 15018-15028 NN denotes inhibition
T13647 15029-15031 IN denotes of
T13648 15032-15037 JJ denotes IFN-γ
T13649 15038-15048 NN denotes production
T13650 15049-15051 IN denotes in
T13651 15052-15054 NNP denotes RA
T13652 15055-15058 NNP denotes CD4
T13653 15058-15059 VBD denotes +
T13654 15060-15061 NNP denotes T
T13655 15062-15067 NNS denotes cells
T13656 15068-15071 DT denotes The
T13657 15072-15076 CD denotes CD28
T13658 15077-15090 JJ denotes costimulatory
T13659 15091-15098 NN denotes pathway
T13660 15099-15101 VBZ denotes is
T13661 15102-15109 JJ denotes crucial
T13662 15110-15113 IN denotes for
T13663 15114-15123 JJ denotes effective
T13664 15124-15140 JJ denotes antigen-specific
T13665 15141-15147 NN denotes T-cell
T13666 15148-15156 NN denotes cytokine
T13667 15157-15167 NN denotes production
T13668 15167-15168 , denotes ,
T13669 15169-15172 CC denotes and
T13670 15173-15178 NNP denotes IL-10
T13671 15179-15182 MD denotes can
T13672 15183-15191 RB denotes directly
T13673 15192-15200 VB denotes suppress
T13674 15201-15205 DT denotes this
T13675 15206-15214 NN denotes response
T13676 15215-15217 IN denotes by
T13677 15218-15228 VBG denotes inhibiting
T13678 15229-15233 NNP denotes CD28
T13679 15234-15242 NN denotes tyrosine
T13680 15243-15258 NN denotes phosphorylation
T13681 15259-15262 CC denotes and
T13682 15263-15270 JJ denotes binding
T13683 15271-15273 IN denotes of
T13684 15274-15294 NN denotes phosphatidylinositol
T13685 15295-15303 JJ denotes 3-kinase
T13686 15304-15305 NNP denotes [
T13687 15305-15307 CD denotes 24
T13688 15307-15308 NNP denotes ]
T13689 15308-15309 . denotes .
T13690 15310-15312 TO denotes To
T13691 15313-15321 VB denotes evaluate
T13692 15322-15325 DT denotes the
T13693 15326-15340 NN denotes responsiveness
T13694 15341-15343 IN denotes of
T13695 15344-15346 NNP denotes RA
T13696 15347-15350 NNP denotes CD4
T13697 15350-15351 VBD denotes +
T13698 15352-15353 NNP denotes T
T13699 15354-15359 NNS denotes cells
T13700 15360-15362 TO denotes to
T13701 15363-15368 NNP denotes IL-10
T13702 15368-15369 , denotes ,
T13703 15370-15378 VBD denotes purified
T13704 15379-15381 NNP denotes PB
T13705 15382-15385 NNP denotes CD4
T13706 15385-15386 VBD denotes +
T13707 15387-15388 NNP denotes T
T13708 15389-15394 NNS denotes cells
T13709 15395-15399 IN denotes from
T13710 15400-15405 CD denotes three
T13711 15406-15414 NNS denotes patients
T13712 15415-15419 IN denotes with
T13713 15420-15426 JJ denotes active
T13714 15427-15429 NNP denotes RA
T13715 15430-15433 CC denotes and
T13716 15434-15438 IN denotes from
T13717 15439-15444 CD denotes three
T13718 15445-15452 JJ denotes healthy
T13719 15453-15461 NNS denotes controls
T13720 15462-15466 VBD denotes were
T13721 15467-15477 VBN denotes stimulated
T13722 15478-15480 IN denotes by
T13723 15481-15492 JJ denotes immobilized
T13724 15493-15501 JJ denotes anti-CD3
T13725 15502-15510 NN denotes antibody
T13726 15511-15514 CC denotes and
T13727 15515-15524 JJ denotes anti-CD28
T13728 15525-15533 NN denotes antibody
T13729 15534-15538 IN denotes with
T13730 15539-15541 CC denotes or
T13731 15542-15549 IN denotes without
T13732 15550-15557 VBN denotes diluted
T13733 15558-15572 NNS denotes concentrations
T13734 15573-15575 IN denotes of
T13735 15576-15581 NN denotes IL-10
T13736 15582-15585 IN denotes for
T13737 15586-15588 CD denotes 36
T13738 15589-15594 NNS denotes hours
T13739 15594-15595 , denotes ,
T13740 15596-15599 CC denotes and
T13741 15600-15605 JJ denotes IFN-γ
T13742 15606-15616 NN denotes production
T13743 15617-15620 VBD denotes was
T13744 15621-15629 VBN denotes measured
T13745 15630-15632 IN denotes by
T13746 15633-15638 NNP denotes ELISA
T13747 15638-15639 . denotes .
T13748 15640-15642 IN denotes As
T13749 15643-15648 VBN denotes shown
T13750 15649-15651 IN denotes in
T13751 15652-15656 NNP denotes Fig.
T13752 15657-15658 CD denotes 1
T13753 15658-15659 , denotes ,
T13754 15660-15665 JJ denotes IFN-γ
T13755 15666-15676 NN denotes production
T13756 15677-15679 IN denotes by
T13757 15680-15689 VBN denotes activated
T13758 15690-15696 JJ denotes normal
T13759 15697-15700 NNP denotes CD4
T13760 15700-15701 CD denotes +
T13761 15702-15703 NNP denotes T
T13762 15704-15709 NNS denotes cells
T13763 15710-15713 VBD denotes was
T13764 15714-15720 RB denotes mostly
T13765 15721-15730 VBN denotes inhibited
T13766 15731-15733 IN denotes at
T13767 15734-15748 NNS denotes concentrations
T13768 15749-15751 RB denotes as
T13769 15752-15755 JJ denotes low
T13770 15756-15758 IN denotes as
T13771 15759-15760 CD denotes 1
T13772 15761-15766 NN denotes ng/ml
T13773 15767-15772 NN denotes IL-10
T13774 15772-15773 . denotes .
T13775 15774-15781 RB denotes However
T13776 15781-15782 , denotes ,
T13777 15783-15785 NNP denotes RA
T13778 15786-15789 NNP denotes CD4
T13779 15789-15790 VBD denotes +
T13780 15791-15792 NNP denotes T
T13781 15793-15798 NNS denotes cells
T13782 15799-15803 VBD denotes were
T13783 15804-15808 JJ denotes able
T13784 15809-15811 TO denotes to
T13785 15812-15819 VB denotes produce
T13786 15820-15831 JJ denotes significant
T13787 15832-15839 NNS denotes amounts
T13788 15840-15842 IN denotes of
T13789 15843-15848 NNP denotes IFN-γ
T13790 15849-15851 IN denotes in
T13791 15852-15855 DT denotes the
T13792 15856-15864 NN denotes presence
T13793 15865-15867 IN denotes of
T13794 15868-15869 CD denotes 1
T13795 15870-15875 NN denotes ng/ml
T13796 15876-15881 NN denotes IL-10
T13797 15881-15882 , denotes ,
T13798 15883-15886 CC denotes and
T13799 15887-15890 DT denotes the
T13800 15891-15898 JJ denotes maximal
T13801 15899-15902 CC denotes but
T13802 15903-15906 RB denotes not
T13803 15907-15915 JJ denotes complete
T13804 15916-15926 NN denotes inhibition
T13805 15927-15929 IN denotes by
T13806 15930-15935 NNP denotes IL-10
T13807 15936-15939 VBD denotes was
T13808 15940-15948 VBN denotes obtained
T13809 15949-15951 IN denotes at
T13810 15952-15954 CD denotes 10
T13811 15955-15958 CD denotes 100
T13812 15959-15964 NN denotes ng/ml
T13813 15964-15965 . denotes .
T13814 15966-15968 PRP denotes We
T13815 15969-15973 RB denotes thus
T13816 15974-15982 VBD denotes compared
T13817 15983-15986 DT denotes the
T13818 15987-15993 NNS denotes levels
T13819 15994-15996 IN denotes of
T13820 15997-16002 JJ denotes IFN-γ
T13821 16003-16013 NN denotes production
T13822 16014-16016 IN denotes by
T13823 16017-16020 NNP denotes CD4
T13824 16020-16021 NNP denotes +
T13825 16022-16023 NNP denotes T
T13826 16024-16029 NNS denotes cells
T13827 16030-16035 IN denotes after
T13828 16036-16039 NNP denotes CD3
T13829 16040-16043 CC denotes and
T13830 16044-16048 NNP denotes CD28
T13831 16049-16062 NN denotes costimulation
T13832 16063-16065 IN denotes in
T13833 16066-16069 DT denotes the
T13834 16070-16078 NN denotes presence
T13835 16079-16081 IN denotes of
T13836 16082-16083 CD denotes 1
T13837 16084-16089 NN denotes ng/ml
T13838 16090-16095 NN denotes IL-10
T13839 16096-16098 IN denotes in
T13840 16099-16101 NNP denotes RA
T13841 16102-16110 NNS denotes patients
T13842 16111-16115 IN denotes with
T13843 16116-16122 JJ denotes active
T13844 16123-16130 NN denotes disease
T13845 16131-16132 -LRB- denotes (
T13846 16132-16140 JJ denotes multiple
T13847 16141-16153 JJ denotes inflammatory
T13848 16154-16160 NNS denotes joints
T13849 16160-16161 , denotes ,
T13850 16162-16165 NNP denotes CRP
T13851 16166-16171 NN denotes level
T13852 16172-16173 NN denotes ≥
T13853 16174-16176 CD denotes 10
T13854 16177-16181 NN denotes mg/l
T13855 16181-16182 -RRB- denotes )
T13856 16183-16186 CC denotes and
T13857 16187-16195 JJ denotes inactive
T13858 16196-16203 NN denotes disease
T13859 16204-16205 -LRB- denotes (
T13860 16205-16207 IN denotes in
T13861 16208-16217 NN denotes remission
T13862 16217-16218 , denotes ,
T13863 16219-16222 NNP denotes CRP
T13864 16223-16228 NN denotes level
T13865 16229-16230 NN denotes <
T13866 16231-16233 CD denotes 10
T13867 16234-16238 NN denotes mg/l
T13868 16238-16239 -RRB- denotes )
T13869 16240-16241 NNP denotes [
T13870 16241-16243 CD denotes 26
T13871 16243-16244 NNP denotes ]
T13872 16245-16248 CC denotes and
T13873 16249-16251 IN denotes in
T13874 16252-16259 JJ denotes healthy
T13875 16260-16268 NNS denotes controls
T13876 16268-16269 . denotes .
T13877 16270-16275 EX denotes There
T13878 16276-16280 VBD denotes were
T13879 16281-16283 DT denotes no
T13880 16284-16297 RB denotes statistically
T13881 16298-16309 JJ denotes significant
T13882 16310-16321 NNS denotes differences
T13883 16322-16324 IN denotes in
T13884 16325-16330 JJ denotes IFN-γ
T13885 16331-16341 NN denotes production
T13886 16342-16349 IN denotes without
T13887 16350-16355 NN denotes IL-10
T13888 16356-16361 IN denotes among
T13889 16362-16367 DT denotes these
T13890 16368-16373 CD denotes three
T13891 16374-16380 NNS denotes groups
T13892 16381-16382 -LRB- denotes (
T13893 16382-16386 NNP denotes Fig.
T13894 16387-16389 CD denotes 2a
T13895 16389-16390 -RRB- denotes )
T13896 16390-16391 , denotes ,
T13897 16392-16395 CC denotes but
T13898 16396-16399 DT denotes the
T13899 16400-16410 JJ denotes inhibitory
T13900 16411-16417 NN denotes effect
T13901 16418-16420 IN denotes of
T13902 16421-16426 NN denotes IL-10
T13903 16427-16429 IN denotes on
T13904 16430-16435 JJ denotes IFN-γ
T13905 16436-16446 NN denotes production
T13906 16447-16450 VBD denotes was
T13907 16451-16464 RB denotes significantly
T13908 16465-16472 VBN denotes limited
T13909 16473-16475 IN denotes in
T13910 16476-16479 DT denotes the
T13911 16480-16486 JJ denotes active
T13912 16487-16489 NNP denotes RA
T13913 16490-16495 NN denotes group
T13914 16496-16498 IN denotes as
T13915 16499-16507 VBN denotes compared
T13916 16508-16512 IN denotes with
T13917 16513-16516 DT denotes the
T13918 16517-16525 JJ denotes inactive
T13919 16526-16528 NNP denotes RA
T13920 16529-16534 NN denotes group
T13921 16535-16538 CC denotes and
T13922 16539-16546 JJ denotes healthy
T13923 16547-16555 NNS denotes controls
T13924 16556-16557 -LRB- denotes (
T13925 16557-16567 NN denotes percentage
T13926 16568-16576 NN denotes decrease
T13927 16576-16577 : denotes :
T13928 16578-16584 JJ denotes active
T13929 16585-16587 NNP denotes RA
T13930 16587-16588 , denotes ,
T13931 16589-16592 CD denotes 2.9
T13932 16593-16594 NN denotes ±
T13933 16595-16599 CD denotes 14.4
T13934 16599-16600 NN denotes %
T13935 16600-16601 : denotes ;
T13936 16602-16610 JJ denotes inactive
T13937 16611-16613 NNP denotes RA
T13938 16613-16614 , denotes ,
T13939 16615-16619 CD denotes 45.6
T13940 16620-16621 NN denotes ±
T13941 16622-16626 CD denotes 14.4
T13942 16626-16627 NN denotes %
T13943 16627-16628 : denotes ;
T13944 16629-16637 NNS denotes controls
T13945 16637-16638 , denotes ,
T13946 16639-16643 CD denotes 65.8
T13947 16644-16645 NN denotes ±
T13948 16646-16649 CD denotes 7.9
T13949 16649-16650 NN denotes %
T13950 16650-16651 -RRB- denotes )
T13951 16652-16653 -LRB- denotes (
T13952 16653-16657 NNP denotes Fig.
T13953 16658-16660 CD denotes 2b
T13954 16660-16661 -RRB- denotes )
T13955 16661-16662 . denotes .
T13956 16663-16665 IN denotes As
T13957 16666-16667 DT denotes a
T13958 16668-16679 NN denotes consequence
T13959 16679-16680 , denotes ,
T13960 16681-16684 NNP denotes CD4
T13961 16684-16685 NNP denotes +
T13962 16686-16687 NNP denotes T
T13963 16688-16693 NNS denotes cells
T13964 16694-16698 IN denotes from
T13965 16699-16705 JJ denotes active
T13966 16706-16708 NNP denotes RA
T13967 16709-16717 NNS denotes patients
T13968 16718-16726 VBD denotes produced
T13969 16727-16733 JJR denotes higher
T13970 16734-16740 NNS denotes levels
T13971 16741-16743 IN denotes of
T13972 16744-16749 NNP denotes IFN-γ
T13973 16750-16752 IN denotes in
T13974 16753-16756 DT denotes the
T13975 16757-16765 NN denotes presence
T13976 16766-16768 IN denotes of
T13977 16769-16770 CD denotes 1
T13978 16771-16776 NN denotes ng/ml
T13979 16777-16782 NN denotes IL-10
T13980 16783-16787 IN denotes than
T13981 16788-16791 VBD denotes did
T13982 16792-16798 JJ denotes normal
T13983 16799-16802 NNP denotes CD4
T13984 16802-16803 CD denotes +
T13985 16804-16805 NNP denotes T
T13986 16806-16811 NNS denotes cells
T13987 16812-16813 -LRB- denotes (
T13988 16813-16817 NNP denotes Fig.
T13989 16818-16820 CD denotes 2a
T13990 16820-16821 -RRB- denotes )
T13991 16821-16822 . denotes .
T13992 16823-16825 IN denotes In
T13993 16826-16834 NN denotes addition
T13994 16834-16835 , denotes ,
T13995 16836-16838 PRP denotes we
T13996 16839-16847 VBD denotes compared
T13997 16848-16852 JJ denotes IL-2
T13998 16853-16863 NN denotes production
T13999 16864-16866 IN denotes by
T14000 16867-16870 NNP denotes CD4
T14001 16870-16871 NNP denotes +
T14002 16872-16873 NNP denotes T
T14003 16874-16879 NNS denotes cells
T14004 16880-16885 IN denotes after
T14005 16886-16889 NNP denotes CD3
T14006 16890-16893 CC denotes and
T14007 16894-16898 NNP denotes CD28
T14008 16899-16912 NN denotes costimulation
T14009 16913-16915 IN denotes in
T14010 16916-16919 DT denotes the
T14011 16920-16928 NN denotes presence
T14012 16929-16931 IN denotes of
T14013 16932-16937 NN denotes IL-10
T14014 16938-16940 IN denotes in
T14015 16941-16947 JJ denotes active
T14016 16948-16950 NNP denotes RA
T14017 16951-16959 NNS denotes patients
T14018 16960-16963 CC denotes and
T14019 16964-16966 IN denotes in
T14020 16967-16974 JJ denotes healthy
T14021 16975-16983 NNS denotes controls
T14022 16983-16984 . denotes .
T14023 16985-16994 RB denotes Similarly
T14024 16994-16995 , denotes ,
T14025 16996-17000 JJ denotes IL-2
T14026 17001-17011 NN denotes production
T14027 17012-17015 VBD denotes was
T14028 17016-17019 RB denotes not
T14029 17020-17028 VBN denotes affected
T14030 17029-17031 IN denotes by
T14031 17032-17033 CD denotes 1
T14032 17034-17039 NN denotes ng/ml
T14033 17040-17045 NN denotes IL-10
T14034 17046-17048 IN denotes in
T14035 17049-17051 NNP denotes RA
T14036 17052-17060 NNS denotes patients
T14037 17061-17062 -LRB- denotes (
T14038 17062-17072 NN denotes percentage
T14039 17073-17081 NN denotes decrease
T14040 17081-17082 , denotes ,
T14041 17083-17087 CD denotes -2.1
T14042 17088-17089 NN denotes ±
T14043 17090-17094 CD denotes 13.8
T14044 17094-17095 NN denotes %
T14045 17095-17096 -RRB- denotes )
T14046 17096-17097 , denotes ,
T14047 17098-17103 IN denotes while
T14048 17104-17106 PRP denotes it
T14049 17107-17110 VBD denotes was
T14050 17111-17124 RB denotes significantly
T14051 17125-17132 VBN denotes reduced
T14052 17133-17135 IN denotes in
T14053 17136-17143 JJ denotes healthy
T14054 17144-17152 NNS denotes controls
T14055 17153-17154 -LRB- denotes (
T14056 17154-17158 CD denotes 61.1
T14057 17159-17160 CD denotes ±
T14058 17161-17165 CD denotes 13.7
T14059 17165-17166 NN denotes %
T14060 17166-17167 : denotes ;
T14061 17168-17169 NNP denotes P
T14062 17170-17171 NNP denotes <
T14063 17172-17176 CD denotes 0.05
T14064 17176-17177 -RRB- denotes )
T14065 17177-17178 . denotes .
T14066 17179-17184 VBN denotes Taken
T14067 17185-17193 RB denotes together
T14068 17193-17194 , denotes ,
T14069 17195-17200 DT denotes these
T14070 17201-17208 NNS denotes results
T14071 17209-17217 VBP denotes indicate
T14072 17218-17222 IN denotes that
T14073 17223-17225 NNP denotes RA
T14074 17226-17229 NNP denotes CD4
T14075 17229-17230 VBD denotes +
T14076 17231-17232 NNP denotes T
T14077 17233-17238 NNS denotes cells
T14078 17239-17245 VBP denotes become
T14079 17246-17250 RBR denotes less
T14080 17251-17262 JJ denotes susceptible
T14081 17263-17265 TO denotes to
T14082 17266-17269 DT denotes the
T14083 17270-17286 JJ denotes immunoregulatory
T14084 17287-17293 NN denotes effect
T14085 17294-17296 IN denotes of
T14086 17297-17302 NN denotes IL-10
T14087 17303-17309 IN denotes during
T14088 17310-17313 DT denotes the
T14089 17314-17320 JJ denotes active
T14090 17321-17326 NN denotes phase
T14091 17326-17327 . denotes .
T15039 17329-17338 VBN denotes Increased
T15040 17339-17349 NN denotes expression
T15041 17350-17352 IN denotes of
T15042 17353-17357 NN denotes cell
T15043 17358-17365 NN denotes surface
T15044 17366-17373 NN denotes IL-10R1
T15045 17374-17376 IN denotes on
T15046 17377-17379 NNP denotes RA
T15047 17380-17383 NNP denotes CD4
T15048 17383-17384 VBD denotes +
T15049 17385-17386 NNP denotes T
T15050 17387-17392 NNS denotes cells
T15051 17393-17396 DT denotes The
T15052 17397-17407 JJ denotes functional
T15053 17408-17416 NN denotes receptor
T15054 17417-17424 NN denotes complex
T15055 17425-17427 IN denotes of
T15056 17428-17433 NN denotes IL-10
T15057 17434-17442 VBZ denotes consists
T15058 17443-17445 IN denotes of
T15059 17446-17449 CD denotes two
T15060 17450-17458 NNS denotes subunits
T15061 17458-17459 , denotes ,
T15062 17460-17463 DT denotes the
T15063 17464-17471 JJ denotes primary
T15064 17472-17486 JJ denotes ligand-binding
T15065 17487-17496 NN denotes component
T15066 17497-17504 NN denotes IL-10R1
T15067 17505-17508 CC denotes and
T15068 17509-17512 DT denotes the
T15069 17513-17522 JJ denotes accessory
T15070 17523-17532 NN denotes component
T15071 17533-17537 NN denotes type
T15072 17538-17539 CD denotes 2
T15073 17540-17546 NNP denotes IL-10R
T15074 17547-17548 NNP denotes [
T15075 17548-17549 CD denotes 1
T15076 17549-17550 NNP denotes ]
T15077 17550-17551 . denotes .
T15078 17552-17559 CD denotes IL-10R1
T15079 17560-17570 NN denotes expression
T15080 17571-17576 VBZ denotes plays
T15081 17577-17578 DT denotes a
T15082 17579-17587 JJ denotes critical
T15083 17588-17592 NN denotes role
T15084 17593-17595 IN denotes in
T15085 17596-17604 JJ denotes cellular
T15086 17605-17614 NNS denotes responses
T15087 17615-17617 TO denotes to
T15088 17618-17623 NNP denotes IL-10
T15089 17624-17625 NNP denotes [
T15090 17625-17627 CD denotes 29
T15091 17627-17628 NNP denotes ]
T15092 17628-17629 . denotes .
T15093 17630-17632 TO denotes To
T15094 17633-17640 VB denotes examine
T15095 17641-17648 IN denotes whether
T15096 17649-17652 DT denotes the
T15097 17653-17663 NN denotes resistance
T15098 17664-17666 TO denotes to
T15099 17667-17672 NNP denotes IL-10
T15100 17673-17683 NN denotes inhibition
T15101 17684-17686 IN denotes in
T15102 17687-17689 NNP denotes RA
T15103 17690-17693 NNP denotes CD4
T15104 17693-17694 VBD denotes +
T15105 17695-17696 NNP denotes T
T15106 17697-17702 NNS denotes cells
T15107 17703-17706 VBD denotes was
T15108 17707-17710 JJ denotes due
T15109 17711-17713 TO denotes to
T15110 17714-17721 JJ denotes limited
T15111 17722-17730 NN denotes receptor
T15112 17731-17741 NN denotes expression
T15113 17741-17742 , denotes ,
T15114 17743-17746 DT denotes the
T15115 17747-17751 NN denotes cell
T15116 17752-17759 NN denotes surface
T15117 17760-17770 NN denotes expression
T15118 17771-17773 IN denotes of
T15119 17774-17781 NN denotes IL-10R1
T15120 17782-17784 IN denotes on
T15121 17785-17787 NNP denotes PB
T15122 17788-17791 NNP denotes CD4
T15123 17791-17792 VBD denotes +
T15124 17793-17794 NNP denotes T
T15125 17795-17800 NNS denotes cells
T15126 17801-17805 IN denotes from
T15127 17806-17812 JJ denotes active
T15128 17813-17815 NNP denotes RA
T15129 17816-17824 NNS denotes patients
T15130 17825-17828 CC denotes and
T15131 17829-17833 IN denotes from
T15132 17834-17841 JJ denotes healthy
T15133 17842-17850 NNS denotes controls
T15134 17851-17854 VBD denotes was
T15135 17855-17865 VBN denotes determined
T15136 17866-17868 IN denotes by
T15137 17869-17873 NN denotes flow
T15138 17874-17884 JJ denotes cytometric
T15139 17885-17893 NN denotes analysis
T15140 17893-17894 . denotes .
T15141 17895-17897 IN denotes As
T15142 17898-17903 VBN denotes shown
T15143 17904-17906 IN denotes in
T15144 17907-17911 NNP denotes Fig.
T15145 17912-17914 CD denotes 3a
T15146 17914-17916 CD denotes ,3
T15147 17916-17917 NN denotes b
T15148 17917-17918 , denotes ,
T15149 17919-17922 DT denotes the
T15150 17923-17932 NN denotes intensity
T15151 17933-17935 IN denotes of
T15152 17936-17943 NN denotes IL-10R1
T15153 17944-17954 NN denotes expression
T15154 17955-17957 IN denotes on
T15155 17958-17961 NNP denotes CD4
T15156 17961-17962 NNP denotes +
T15157 17963-17964 NNP denotes T
T15158 17965-17970 NNS denotes cells
T15159 17971-17974 VBD denotes was
T15160 17975-17988 RB denotes significantly
T15161 17989-17998 VBN denotes increased
T15162 17999-18001 IN denotes in
T15163 18002-18004 NNP denotes RA
T15164 18005-18013 NNS denotes patients
T15165 18014-18022 VBN denotes compared
T15166 18023-18027 IN denotes with
T15167 18028-18030 IN denotes in
T15168 18031-18038 JJ denotes healthy
T15169 18039-18047 NNS denotes controls
T15170 18047-18048 . denotes .
T15171 18049-18054 DT denotes These
T15172 18055-18062 NNS denotes results
T15173 18063-18070 VBP denotes suggest
T15174 18071-18075 IN denotes that
T15175 18076-18079 DT denotes the
T15176 18080-18093 JJ denotes intracellular
T15177 18094-18100 NN denotes signal
T15178 18101-18113 NN denotes transduction
T15179 18114-18121 NN denotes pathway
T15180 18122-18124 IN denotes of
T15181 18125-18130 NN denotes IL-10
T15182 18131-18134 MD denotes may
T15183 18135-18137 VB denotes be
T15184 18138-18146 VBN denotes impaired
T15185 18147-18149 IN denotes in
T15186 18150-18153 CD denotes CD4
T15187 18153-18154 CD denotes +
T15188 18155-18156 NNP denotes T
T15189 18157-18162 NNS denotes cells
T15190 18163-18165 IN denotes of
T15191 18166-18172 JJ denotes active
T15192 18173-18175 NNP denotes RA
T15193 18175-18176 . denotes .
T16494 18178-18187 JJ denotes Defective
T16495 18188-18202 JJ denotes IL-10-mediated
T16496 18203-18208 CD denotes STAT3
T16497 18209-18224 NN denotes phosphorylation
T16498 18225-18227 IN denotes in
T16499 18228-18230 NNP denotes RA
T16500 18231-18234 NNP denotes CD4
T16501 18234-18235 VBD denotes +
T16502 18236-18237 NNP denotes T
T16503 18238-18243 NNS denotes cells
T16504 18244-18247 DT denotes The
T16505 18248-18259 NN denotes interaction
T16506 18260-18262 IN denotes of
T16507 18263-18269 NN denotes IL-10R
T16508 18270-18274 IN denotes with
T16509 18275-18280 JJ denotes IL-10
T16510 18281-18288 VBZ denotes induces
T16511 18289-18297 NN denotes tyrosine
T16512 18298-18313 NN denotes phosphorylation
T16513 18314-18317 CC denotes and
T16514 18318-18328 NN denotes activation
T16515 18329-18331 IN denotes of
T16516 18332-18335 DT denotes the
T16517 18336-18342 NN denotes latent
T16518 18343-18356 NN denotes transcription
T16519 18357-18364 NNS denotes factors
T16520 18365-18370 NNP denotes STAT1
T16521 18371-18374 CC denotes and
T16522 18375-18380 NNP denotes STAT3
T16523 18381-18382 NNP denotes [
T16524 18382-18383 CD denotes 3
T16525 18383-18384 NNP denotes ]
T16526 18384-18385 . denotes .
T16527 18386-18405 JJ denotes Macrophage-specific
T16528 18406-18421 JJ denotes STAT3-deficient
T16529 18422-18426 NNS denotes mice
T16530 18427-18439 VBD denotes demonstrated
T16531 18440-18444 IN denotes that
T16532 18445-18450 CD denotes STAT3
T16533 18451-18456 VBZ denotes plays
T16534 18457-18458 DT denotes a
T16535 18459-18467 JJ denotes dominant
T16536 18468-18472 NN denotes role
T16537 18473-18475 IN denotes in
T16538 18476-18490 JJ denotes IL-10-mediated
T16539 18491-18508 JJ denotes anti-inflammatory
T16540 18509-18518 NNS denotes responses
T16541 18519-18520 VBP denotes [
T16542 18520-18521 CD denotes 5
T16543 18521-18522 NNP denotes ]
T16544 18522-18523 , denotes ,
T16545 18524-18529 WDT denotes which
T16546 18530-18533 VBZ denotes has
T16547 18534-18542 RB denotes recently
T16548 18543-18547 VBN denotes been
T16549 18548-18557 VBN denotes confirmed
T16550 18558-18560 IN denotes in
T16551 18561-18566 JJ denotes human
T16552 18567-18578 NNS denotes macrophages
T16553 18579-18581 IN denotes by
T16554 18582-18589 NNS denotes studies
T16555 18590-18592 IN denotes of
T16556 18593-18610 JJ denotes dominant-negative
T16557 18611-18616 CD denotes STAT3
T16558 18617-18631 NN denotes overexpression
T16559 18632-18633 NNP denotes [
T16560 18633-18635 CD denotes 30
T16561 18635-18636 NNP denotes ]
T16562 18636-18637 . denotes .
T16563 18638-18641 DT denotes The
T16564 18642-18651 NN denotes induction
T16565 18652-18654 IN denotes of
T16566 18655-18660 CD denotes STAT1
T16567 18661-18664 CC denotes and
T16568 18665-18670 CD denotes STAT3
T16569 18671-18686 NN denotes phosphorylation
T16570 18687-18689 IN denotes by
T16571 18690-18695 NNP denotes IL-10
T16572 18696-18698 IN denotes in
T16573 18699-18701 NNP denotes PB
T16574 18702-18705 NNP denotes CD4
T16575 18705-18706 VBD denotes +
T16576 18707-18708 NNP denotes T
T16577 18709-18714 NNS denotes cells
T16578 18715-18719 IN denotes from
T16579 18720-18726 JJ denotes active
T16580 18727-18729 NNP denotes RA
T16581 18730-18738 NNS denotes patients
T16582 18739-18742 CC denotes and
T16583 18743-18747 IN denotes from
T16584 18748-18755 JJ denotes healthy
T16585 18756-18764 NNS denotes controls
T16586 18765-18768 VBD denotes was
T16587 18769-18777 VBN denotes examined
T16588 18778-18783 VBG denotes using
T16589 18784-18791 JJ denotes western
T16590 18792-18800 VBG denotes blotting
T16591 18800-18801 . denotes .
T16592 18802-18807 CD denotes STAT3
T16593 18808-18823 NN denotes phosphorylation
T16594 18824-18827 VBD denotes was
T16595 18828-18844 RB denotes dose-dependently
T16596 18845-18852 VBN denotes induced
T16597 18853-18858 IN denotes after
T16598 18859-18864 NNP denotes IL-10
T16599 18865-18875 NN denotes activation
T16600 18876-18879 IN denotes for
T16601 18880-18882 CD denotes 20
T16602 18883-18886 NN denotes min
T16603 18887-18889 IN denotes in
T16604 18890-18896 JJ denotes normal
T16605 18897-18900 NNP denotes CD4
T16606 18900-18901 CD denotes +
T16607 18902-18903 NNP denotes T
T16608 18904-18909 NNS denotes cells
T16609 18910-18911 -LRB- denotes (
T16610 18911-18915 NNP denotes Fig.
T16611 18916-18918 CD denotes 4a
T16612 18918-18920 CD denotes ,4
T16613 18920-18921 NN denotes b
T16614 18921-18922 -RRB- denotes )
T16615 18922-18923 . denotes .
T16616 18924-18926 IN denotes In
T16617 18927-18935 NN denotes contrast
T16618 18935-18936 , denotes ,
T16619 18937-18942 NNP denotes STAT3
T16620 18943-18946 VBD denotes was
T16621 18947-18961 VBN denotes phosphorylated
T16622 18962-18964 IN denotes in
T16623 18965-18972 RB denotes freshly
T16624 18973-18981 VBN denotes isolated
T16625 18982-18984 NNP denotes PB
T16626 18985-18988 NNP denotes CD4
T16627 18988-18989 VBD denotes +
T16628 18990-18995 NNS denotes cells
T16629 18996-19000 IN denotes from
T16630 19001-19003 NNP denotes RA
T16631 19004-19012 NNS denotes patients
T16632 19013-19016 CC denotes and
T16633 19017-19021 DT denotes this
T16634 19022-19027 CD denotes STAT3
T16635 19028-19043 NN denotes phosphorylation
T16636 19044-19047 VBD denotes was
T16637 19048-19058 JJ denotes detectable
T16638 19059-19062 IN denotes for
T16639 19063-19065 RB denotes up
T16640 19066-19068 TO denotes to
T16641 19069-19070 CD denotes 6
T16642 19071-19076 NNS denotes hours
T16643 19076-19077 . denotes .
T16644 19078-19083 CD denotes STAT3
T16645 19084-19099 NN denotes phosphorylation
T16646 19100-19103 VBD denotes was
T16647 19104-19113 VBN denotes augmented
T16648 19114-19118 RB denotes only
T16649 19119-19123 WRB denotes when
T16650 19124-19133 VBN denotes activated
T16651 19134-19136 IN denotes by
T16652 19137-19139 RB denotes as
T16653 19140-19144 JJ denotes much
T16654 19145-19147 IN denotes as
T16655 19148-19150 CD denotes 10
T16656 19151-19156 NN denotes ng/ml
T16657 19157-19162 NN denotes IL-10
T16658 19162-19163 . denotes .
T16659 19164-19168 DT denotes Both
T16660 19169-19178 VBN denotes sustained
T16661 19179-19184 CD denotes STAT3
T16662 19185-19200 NN denotes phosphorylation
T16663 19201-19204 CC denotes and
T16664 19205-19214 JJ denotes defective
T16665 19215-19228 JJ denotes IL-10-induced
T16666 19229-19234 CD denotes STAT3
T16667 19235-19250 NN denotes phosphorylation
T16668 19251-19255 VBD denotes were
T16669 19256-19261 VBN denotes found
T16670 19262-19264 IN denotes in
T16671 19265-19267 NNP denotes RA
T16672 19268-19270 NNP denotes ST
T16673 19271-19274 NNP denotes CD4
T16674 19274-19275 VBD denotes +
T16675 19276-19277 NNP denotes T
T16676 19278-19283 NNS denotes cells
T16677 19284-19285 -LRB- denotes (
T16678 19285-19289 NNP denotes Fig.
T16679 19290-19292 CD denotes 4c
T16680 19292-19293 -RRB- denotes )
T16681 19293-19294 . denotes .
T16682 19295-19297 IN denotes On
T16683 19298-19301 DT denotes the
T16684 19302-19307 JJ denotes other
T16685 19308-19312 NN denotes hand
T16686 19312-19313 , denotes ,
T16687 19314-19327 JJ denotes IL-10-induced
T16688 19328-19333 CD denotes STAT1
T16689 19334-19349 NN denotes phosphorylation
T16690 19350-19353 VBD denotes was
T16691 19354-19357 RB denotes not
T16692 19358-19366 VBN denotes detected
T16693 19367-19369 IN denotes in
T16694 19370-19376 DT denotes either
T16695 19377-19379 NNP denotes RA
T16696 19380-19383 NNP denotes CD4
T16697 19383-19384 VBD denotes +
T16698 19385-19386 NNP denotes T
T16699 19387-19392 NNS denotes cells
T16700 19393-19395 CC denotes or
T16701 19396-19402 JJ denotes normal
T16702 19403-19406 NNP denotes CD4
T16703 19406-19407 CD denotes +
T16704 19408-19409 NNP denotes T
T16705 19410-19415 NNS denotes cells
T16706 19416-19417 -LRB- denotes (
T16707 19417-19421 NNP denotes Fig.
T16708 19422-19424 CD denotes 4a
T16709 19424-19425 -RRB- denotes )
T16710 19425-19426 . denotes .
T16711 19427-19432 DT denotes These
T16712 19433-19440 NNS denotes results
T16713 19441-19449 VBP denotes indicate
T16714 19450-19454 IN denotes that
T16715 19455-19460 CD denotes STAT3
T16716 19461-19463 VBZ denotes is
T16717 19464-19467 DT denotes the
T16718 19468-19473 JJ denotes major
T16719 19474-19489 JJ denotes IL-10-activated
T16720 19490-19494 NNP denotes STAT
T16721 19495-19497 IN denotes in
T16722 19498-19501 NNP denotes CD4
T16723 19501-19502 NNP denotes +
T16724 19503-19504 NNP denotes T
T16725 19505-19510 NNS denotes cells
T16726 19510-19511 , denotes ,
T16727 19512-19515 CC denotes and
T16728 19516-19529 JJ denotes IL-10-induced
T16729 19530-19535 CD denotes STAT3
T16730 19536-19546 NN denotes activation
T16731 19547-19550 MD denotes may
T16732 19551-19553 VB denotes be
T16733 19554-19564 VBN denotes diminished
T16734 19565-19567 IN denotes in
T16735 19568-19574 JJ denotes active
T16736 19575-19577 NNP denotes RA
T16737 19577-19578 , denotes ,
T16738 19579-19581 IN denotes in
T16739 19582-19593 NN denotes association
T16740 19594-19598 IN denotes with
T16741 19599-19608 VBN denotes sustained
T16742 19609-19614 NNP denotes STAT3
T16743 19615-19630 NN denotes phosphorylation
T16744 19630-19631 . denotes .
T19005 19633-19646 JJ denotes IL-6-mediated
T19006 19647-19652 CD denotes STAT3
T19007 19653-19668 NN denotes phosphorylation
T19008 19669-19672 CC denotes and
T19009 19673-19683 NN denotes inhibition
T19010 19684-19686 IN denotes of
T19011 19687-19692 JJ denotes IL-10
T19012 19693-19699 NN denotes effect
T19013 19700-19702 IN denotes in
T19014 19703-19709 JJ denotes normal
T19015 19710-19713 NNP denotes CD4
T19016 19713-19714 CD denotes +
T19017 19715-19716 NNP denotes T
T19018 19717-19722 NNS denotes cells
T19019 19723-19728 NNP denotes STAT3
T19020 19729-19731 VBZ denotes is
T19021 19732-19741 VBN denotes activated
T19022 19742-19744 IN denotes by
T19023 19745-19749 JJ denotes many
T19024 19750-19759 NNS denotes cytokines
T19025 19760-19763 CC denotes and
T19026 19764-19770 NN denotes growth
T19027 19771-19778 NNS denotes factors
T19028 19779-19783 JJ denotes such
T19029 19784-19786 IN denotes as
T19030 19787-19790 DT denotes the
T19031 19791-19795 NNP denotes IL-6
T19032 19796-19802 NN denotes family
T19033 19803-19805 IN denotes of
T19034 19806-19815 NNS denotes cytokines
T19035 19816-19817 -LRB- denotes (
T19036 19817-19821 NNP denotes IL-6
T19037 19821-19822 , denotes ,
T19038 19823-19828 NNP denotes IL-11
T19039 19828-19829 , denotes ,
T19040 19830-19838 NN denotes leukemia
T19041 19839-19849 JJ denotes inhibitory
T19042 19850-19856 NN denotes factor
T19043 19856-19857 , denotes ,
T19044 19858-19861 CC denotes and
T19045 19862-19872 NN denotes oncostatin
T19046 19873-19874 NNP denotes M
T19047 19874-19875 -RRB- denotes )
T19048 19875-19876 , denotes ,
T19049 19877-19893 JJ denotes platelet-derived
T19050 19894-19900 NN denotes growth
T19051 19901-19907 NN denotes factor
T19052 19907-19908 , denotes ,
T19053 19909-19912 CC denotes and
T19054 19913-19922 JJ denotes epidermal
T19055 19923-19929 NN denotes growth
T19056 19930-19936 NN denotes factor
T19057 19936-19937 , denotes ,
T19058 19938-19940 IN denotes in
T19059 19941-19949 NN denotes addition
T19060 19950-19952 TO denotes to
T19061 19953-19958 NNP denotes IL-10
T19062 19959-19960 NNP denotes [
T19063 19960-19961 CD denotes 4
T19064 19961-19962 NNP denotes ]
T19065 19962-19963 , denotes ,
T19066 19964-19967 CC denotes but
T19067 19968-19976 JJ denotes previous
T19068 19977-19984 NNS denotes studies
T19069 19985-19989 VBP denotes have
T19070 19990-20002 VBN denotes demonstrated
T19071 20003-20007 IN denotes that
T19072 20008-20012 NNP denotes IL-6
T19073 20013-20015 VBZ denotes is
T19074 20016-20019 DT denotes the
T19075 20020-20025 JJ denotes major
T19076 20026-20032 NN denotes factor
T19077 20033-20035 IN denotes in
T19078 20036-20038 NNP denotes RA
T19079 20039-20047 JJ denotes synovial
T19080 20048-20053 NN denotes fluid
T19081 20054-20058 WDT denotes that
T19082 20059-20066 VBZ denotes induces
T19083 20067-20079 JJ denotes constitutive
T19084 20080-20090 NN denotes activation
T19085 20091-20093 IN denotes of
T19086 20094-20099 CD denotes STAT3
T19087 20100-20102 IN denotes in
T19088 20103-20114 NN denotes mononuclear
T19089 20115-20120 NNS denotes cells
T19090 20121-20122 NNP denotes [
T19091 20122-20124 CD denotes 31
T19092 20124-20125 NNP denotes ]
T19093 20125-20126 . denotes .
T19094 20127-20132 IN denotes Since
T19095 20133-20137 NNP denotes IL-6
T19096 20138-20140 VBZ denotes is
T19097 20141-20145 RB denotes also
T19098 20146-20154 JJ denotes abundant
T19099 20155-20157 IN denotes in
T19100 20158-20162 NN denotes sera
T19101 20163-20165 IN denotes of
T19102 20166-20172 JJ denotes active
T19103 20173-20175 NNP denotes RA
T19104 20176-20184 NNS denotes patients
T19105 20184-20185 , denotes ,
T19106 20186-20196 RB denotes frequently
T19107 20197-20205 VBN denotes detected
T19108 20206-20208 IN denotes at
T19109 20209-20210 CD denotes >
T19110 20211-20212 CD denotes 1
T19111 20213-20218 VBN denotes ng/ml
T19112 20219-20220 NNP denotes [
T19113 20220-20222 CD denotes 27
T19114 20222-20223 NNP denotes ]
T19115 20223-20224 , denotes ,
T19116 20225-20227 PRP denotes we
T19117 20228-20236 VBD denotes examined
T19118 20237-20244 IN denotes whether
T19119 20245-20255 JJ denotes persistent
T19120 20256-20264 NN denotes exposure
T19121 20265-20267 IN denotes of
T19122 20268-20271 CD denotes CD4
T19123 20271-20272 CD denotes +
T19124 20273-20274 NNP denotes T
T19125 20275-20280 NNS denotes cells
T19126 20281-20283 TO denotes to
T19127 20284-20288 JJ denotes high
T19128 20289-20303 NNS denotes concentrations
T19129 20304-20306 IN denotes of
T19130 20307-20311 NN denotes IL-6
T19131 20312-20314 IN denotes in
T19132 20315-20318 DT denotes the
T19133 20319-20324 NN denotes blood
T19134 20325-20336 NN denotes circulation
T19135 20337-20340 VBD denotes was
T19136 20341-20352 JJ denotes responsible
T19137 20353-20356 IN denotes for
T19138 20357-20362 PRP$ denotes their
T19139 20363-20372 VBN denotes sustained
T19140 20373-20378 CD denotes STAT3
T19141 20379-20389 NN denotes activation
T19142 20390-20393 CC denotes and
T19143 20394-20404 NN denotes resistance
T19144 20405-20407 TO denotes to
T19145 20408-20413 NNP denotes IL-10
T19146 20414-20424 NN denotes inhibition
T19147 20425-20427 IN denotes in
T19148 20428-20434 JJ denotes active
T19149 20435-20437 NNP denotes RA
T19150 20437-20438 . denotes .
T19151 20439-20443 DT denotes Both
T19152 20444-20449 CD denotes STAT1
T19153 20450-20453 CC denotes and
T19154 20454-20459 CD denotes STAT3
T19155 20460-20475 NN denotes phosphorylation
T19156 20476-20479 VBD denotes was
T19157 20480-20489 VBN denotes activated
T19158 20490-20492 IN denotes by
T19159 20493-20497 NN denotes IL-6
T19160 20498-20500 IN denotes in
T19161 20501-20507 JJ denotes normal
T19162 20508-20511 NNP denotes CD4
T19163 20511-20512 CD denotes +
T19164 20513-20514 NNP denotes T
T19165 20515-20520 NNS denotes cells
T19166 20521-20522 -LRB- denotes (
T19167 20522-20526 NNS denotes data
T19168 20527-20530 RB denotes not
T19169 20531-20536 VBN denotes shown
T19170 20536-20537 -RRB- denotes )
T19171 20537-20538 , denotes ,
T19172 20539-20541 IN denotes in
T19173 20542-20551 NN denotes agreement
T19174 20552-20556 IN denotes with
T19175 20557-20565 JJ denotes previous
T19176 20566-20578 NNS denotes observations
T19177 20579-20580 VBP denotes [
T19178 20580-20581 CD denotes 4
T19179 20581-20582 NNP denotes ]
T19180 20582-20583 . denotes .
T19181 20584-20590 JJ denotes Normal
T19182 20591-20594 NNP denotes CD4
T19183 20594-20595 CD denotes +
T19184 20596-20597 NNP denotes T
T19185 20598-20603 NNS denotes cells
T19186 20604-20608 VBD denotes were
T19187 20609-20613 RB denotes thus
T19188 20614-20623 VBN denotes incubated
T19189 20624-20627 IN denotes for
T19190 20628-20630 CD denotes 20
T19191 20631-20634 NN denotes min
T19192 20635-20639 IN denotes with
T19193 20640-20647 NN denotes culture
T19194 20648-20654 NN denotes medium
T19195 20655-20665 VBG denotes containing
T19196 20666-20668 CD denotes 30
T19197 20668-20669 NN denotes %
T19198 20670-20675 NN denotes serum
T19199 20676-20680 IN denotes from
T19200 20681-20687 JJ denotes active
T19201 20688-20690 NNP denotes RA
T19202 20691-20699 NNS denotes patients
T19203 20700-20703 CC denotes and
T19204 20704-20716 VBG denotes neutralizing
T19205 20717-20726 JJ denotes anti-IL-6
T19206 20727-20735 NN denotes antibody
T19207 20736-20738 CC denotes or
T19208 20739-20746 NN denotes control
T19209 20747-20755 NN denotes antibody
T19210 20755-20756 , denotes ,
T19211 20757-20760 CC denotes and
T19212 20761-20765 NNP denotes STAT
T19213 20766-20781 NN denotes phosphorylation
T19214 20782-20785 VBD denotes was
T19215 20786-20794 VBN denotes examined
T19216 20795-20797 IN denotes by
T19217 20798-20805 JJ denotes western
T19218 20806-20810 NN denotes blot
T19219 20811-20819 NN denotes analysis
T19220 20819-20820 . denotes .
T19221 20821-20823 NNP denotes RA
T19222 20824-20829 NN denotes serum
T19223 20830-20833 VBD denotes was
T19224 20834-20838 JJ denotes able
T19225 20839-20841 TO denotes to
T19226 20842-20848 VB denotes induce
T19227 20849-20857 JJ denotes tyrosine
T19228 20858-20873 NN denotes phosphorylation
T19229 20874-20876 IN denotes of
T19230 20877-20882 CD denotes STAT3
T19231 20883-20886 CC denotes but
T19232 20887-20890 RB denotes not
T19233 20891-20896 NNP denotes STAT1
T19234 20896-20897 , denotes ,
T19235 20898-20901 CC denotes and
T19236 20902-20906 DT denotes this
T19237 20907-20912 CD denotes STAT3
T19238 20913-20923 NN denotes activation
T19239 20924-20927 VBD denotes was
T19240 20928-20934 RB denotes mostly
T19241 20935-20944 VBN denotes abolished
T19242 20945-20947 IN denotes by
T19243 20948-20962 NN denotes neutralization
T19244 20963-20965 IN denotes of
T19245 20966-20970 NN denotes IL-6
T19246 20971-20979 NN denotes activity
T19247 20980-20981 -LRB- denotes (
T19248 20981-20985 NNP denotes Fig.
T19249 20986-20988 CD denotes 5a
T19250 20988-20989 -RRB- denotes )
T19251 20989-20990 . denotes .
T19252 20991-20996 DT denotes These
T19253 20997-21004 NNS denotes results
T19254 21005-21013 VBP denotes indicate
T19255 21014-21018 IN denotes that
T19256 21019-21023 NNP denotes IL-6
T19257 21024-21026 VBZ denotes is
T19258 21027-21030 DT denotes the
T19259 21031-21039 JJ denotes dominant
T19260 21040-21056 JJ denotes STAT3-activating
T19261 21057-21063 NN denotes factor
T19262 21064-21073 VBN denotes contained
T19263 21074-21076 IN denotes in
T19264 21077-21081 NN denotes sera
T19265 21082-21084 IN denotes of
T19266 21085-21091 JJ denotes active
T19267 21092-21094 NNP denotes RA
T19268 21095-21103 NNS denotes patients
T19269 21103-21104 . denotes .
T19270 21105-21108 DT denotes The
T19271 21109-21113 NN denotes lack
T19272 21114-21116 IN denotes of
T19273 21117-21122 CD denotes STAT1
T19274 21123-21133 NN denotes activation
T19275 21134-21136 IN denotes by
T19276 21137-21139 NNP denotes RA
T19277 21140-21145 NN denotes serum
T19278 21146-21154 VBZ denotes suggests
T19279 21155-21159 IN denotes that
T19280 21160-21164 RB denotes much
T19281 21165-21171 JJR denotes higher
T19282 21172-21186 NNS denotes concentrations
T19283 21187-21189 IN denotes of
T19284 21190-21194 NN denotes IL-6
T19285 21195-21198 MD denotes may
T19286 21199-21201 VB denotes be
T19287 21202-21210 VBN denotes required
T19288 21211-21214 IN denotes for
T19289 21215-21220 CD denotes STAT1
T19290 21221-21231 NN denotes activation
T19291 21232-21234 IN denotes as
T19292 21235-21243 VBN denotes compared
T19293 21244-21248 IN denotes with
T19294 21249-21254 CD denotes STAT3
T19295 21255-21265 NN denotes activation
T19296 21265-21266 , denotes ,
T19297 21267-21269 CC denotes or
T19298 21270-21274 DT denotes that
T19299 21275-21285 NNS denotes inhibitors
T19300 21286-21288 IN denotes of
T19301 21289-21294 CD denotes STAT1
T19302 21295-21304 VBG denotes signaling
T19303 21305-21308 MD denotes may
T19304 21309-21311 VB denotes be
T19305 21312-21319 JJ denotes present
T19306 21320-21322 IN denotes in
T19307 21323-21325 NNP denotes RA
T19308 21326-21331 NN denotes serum
T19309 21331-21332 . denotes .
T19310 21333-21335 PRP denotes We
T19311 21336-21340 JJ denotes next
T19312 21341-21349 VBD denotes examined
T19313 21350-21357 IN denotes whether
T19314 21358-21362 NN denotes IL-6
T19315 21363-21368 MD denotes could
T19316 21369-21377 VB denotes suppress
T19317 21378-21381 DT denotes the
T19318 21382-21388 NN denotes effect
T19319 21389-21391 IN denotes of
T19320 21392-21397 NN denotes IL-10
T19321 21398-21400 TO denotes to
T19322 21401-21408 VB denotes inhibit
T19323 21409-21414 JJ denotes IFN-γ
T19324 21415-21425 NN denotes production
T19325 21426-21428 IN denotes by
T19326 21429-21432 NNP denotes CD4
T19327 21432-21433 NNP denotes +
T19328 21434-21435 NNP denotes T
T19329 21436-21441 NNS denotes cells
T19330 21441-21442 . denotes .
T19331 21443-21448 IN denotes After
T19332 21449-21462 NN denotes preincubation
T19333 21463-21467 IN denotes with
T19334 21468-21470 CC denotes or
T19335 21471-21478 IN denotes without
T19336 21479-21481 CD denotes 10
T19337 21482-21487 NN denotes ng/ml
T19338 21488-21492 NN denotes IL-6
T19339 21493-21496 IN denotes for
T19340 21497-21499 CD denotes 36
T19341 21500-21505 NNS denotes hours
T19342 21505-21506 , denotes ,
T19343 21507-21513 JJ denotes normal
T19344 21514-21517 NNP denotes CD4
T19345 21517-21518 CD denotes +
T19346 21519-21520 NNP denotes T
T19347 21521-21526 NNS denotes cells
T19348 21527-21531 VBD denotes were
T19349 21532-21542 VBN denotes stimulated
T19350 21543-21545 IN denotes by
T19351 21546-21549 NNP denotes CD3
T19352 21550-21553 CC denotes and
T19353 21554-21558 NNP denotes CD28
T19354 21559-21572 NN denotes costimulation
T19355 21573-21575 IN denotes in
T19356 21576-21579 DT denotes the
T19357 21580-21588 NN denotes presence
T19358 21589-21591 CC denotes or
T19359 21592-21599 NN denotes absence
T19360 21600-21602 IN denotes of
T19361 21603-21604 CD denotes 1
T19362 21605-21610 NN denotes ng/ml
T19363 21611-21616 NN denotes IL-10
T19364 21617-21620 IN denotes for
T19365 21621-21623 CD denotes 36
T19366 21624-21629 NNS denotes hours
T19367 21629-21630 , denotes ,
T19368 21631-21634 CC denotes and
T19369 21635-21638 DT denotes the
T19370 21639-21644 JJ denotes IFN-γ
T19371 21645-21655 NN denotes production
T19372 21656-21659 VBD denotes was
T19373 21660-21668 VBN denotes measured
T19374 21669-21671 IN denotes by
T19375 21672-21677 NNP denotes ELISA
T19376 21677-21678 . denotes .
T19377 21679-21683 CD denotes IL-6
T19378 21684-21696 NN denotes pretreatment
T19379 21697-21699 IN denotes of
T19380 21700-21706 JJ denotes normal
T19381 21707-21712 NNS denotes cells
T19382 21713-21720 VBN denotes reduced
T19383 21721-21735 JJ denotes IL-10-mediated
T19384 21736-21746 NN denotes inhibition
T19385 21747-21749 IN denotes of
T19386 21750-21755 JJ denotes IFN-γ
T19387 21756-21766 NN denotes production
T19388 21767-21768 -LRB- denotes (
T19389 21768-21772 NNP denotes Fig.
T19390 21773-21775 CD denotes 5b
T19391 21775-21776 -RRB- denotes )
T19392 21776-21777 , denotes ,
T19393 21778-21788 VBG denotes indicating
T19394 21789-21793 IN denotes that
T19395 21794-21798 JJ denotes high
T19396 21799-21813 NNS denotes concentrations
T19397 21814-21816 IN denotes of
T19398 21817-21821 NN denotes IL-6
T19399 21822-21827 MD denotes could
T19400 21828-21836 VB denotes modulate
T19401 21837-21843 NNP denotes T-cell
T19402 21844-21858 NN denotes responsiveness
T19403 21859-21861 TO denotes to
T19404 21862-21867 NNP denotes IL-10
T19405 21867-21868 . denotes .
T19406 21869-21874 VBN denotes Taken
T19407 21875-21883 RB denotes together
T19408 21883-21884 , denotes ,
T19409 21885-21890 DT denotes these
T19410 21891-21899 NNS denotes findings
T19411 21900-21907 VBP denotes suggest
T19412 21908-21912 IN denotes that
T19413 21913-21923 JJ denotes persistent
T19414 21924-21932 NN denotes exposure
T19415 21933-21935 TO denotes to
T19416 21936-21941 VB denotes serum
T19417 21942-21946 NNP denotes IL-6
T19418 21947-21950 MD denotes may
T19419 21951-21955 VB denotes have
T19420 21956-21957 DT denotes a
T19421 21958-21962 NN denotes role
T19422 21963-21965 IN denotes in
T19423 21966-21970 DT denotes both
T19424 21971-21974 DT denotes the
T19425 21975-21984 NN denotes induction
T19426 21985-21987 IN denotes of
T19427 21988-21993 CD denotes STAT3
T19428 21994-22004 NN denotes activation
T19429 22005-22008 CC denotes and
T19430 22009-22012 DT denotes the
T19431 22013-22023 NN denotes resistance
T19432 22024-22026 TO denotes to
T19433 22027-22030 DT denotes the
T19434 22031-22041 JJ denotes inhibitory
T19435 22042-22048 NN denotes effect
T19436 22049-22051 IN denotes of
T19437 22052-22057 NN denotes IL-10
T19438 22058-22060 IN denotes in
T19439 22061-22063 NNP denotes RA
T19440 22064-22067 NNP denotes CD4
T19441 22067-22068 VBD denotes +
T19442 22069-22070 NNP denotes T
T19443 22071-22076 NNS denotes cells
T19444 22076-22077 . denotes .
T20959 22079-22083 NNP denotes High
T20960 22084-22094 NN denotes expression
T20961 22095-22097 IN denotes of
T20962 22098-22103 CD denotes SOCS1
T20963 22104-22108 NNP denotes mRNA
T20964 22109-22111 IN denotes in
T20965 22112-22114 NNP denotes RA
T20966 22115-22118 NNP denotes CD4
T20967 22118-22119 VBD denotes +
T20968 22120-22121 NNP denotes T
T20969 22122-22127 NNS denotes cells
T20970 22128-22132 NNP denotes IL-6
T20971 22133-22140 VBZ denotes induces
T20972 22141-22144 CD denotes two
T20973 22145-22151 JJ denotes potent
T20974 22152-22162 NNS denotes inhibitors
T20975 22163-22165 IN denotes of
T20976 22166-22170 NNS denotes JAKs
T20977 22171-22172 -LRB- denotes (
T20978 22172-22177 CD denotes SOCS1
T20979 22178-22181 CC denotes and
T20980 22182-22187 CD denotes SOCS3
T20981 22188-22196 NNS denotes proteins
T20982 22196-22197 -RRB- denotes )
T20983 22198-22202 IN denotes that
T20984 22203-22206 RB denotes not
T20985 22207-22211 JJ denotes only
T20986 22212-22215 NN denotes act
T20987 22216-22218 IN denotes as
T20988 22219-22228 NNS denotes mediators
T20989 22229-22231 IN denotes of
T20990 22232-22240 JJ denotes negative
T20991 22241-22249 NN denotes feedback
T20992 22250-22260 NN denotes inhibition
T20993 22260-22261 , denotes ,
T20994 22262-22265 CC denotes but
T20995 22266-22270 RB denotes also
T20996 22271-22275 VB denotes play
T20997 22276-22277 DT denotes a
T20998 22278-22283 JJ denotes major
T20999 22284-22288 NN denotes role
T21000 22289-22291 IN denotes in
T21001 22292-22301 NN denotes crosstalk
T21002 22302-22312 NN denotes inhibition
T21003 22313-22315 IN denotes by
T21004 22316-22324 VBG denotes opposing
T21005 22325-22330 JJ denotes other
T21006 22331-22349 JJ denotes cytokine-signaling
T21007 22350-22358 NNS denotes pathways
T21008 22359-22360 VBP denotes [
T21009 22360-22361 CD denotes 7
T21010 22361-22362 NNP denotes ]
T21011 22362-22363 . denotes .
T21012 22364-22369 CD denotes SOCS3
T21013 22370-22373 VBZ denotes has
T21014 22374-22382 RB denotes recently
T21015 22383-22387 VBN denotes been
T21016 22388-22393 VBN denotes shown
T21017 22394-22396 TO denotes to
T21018 22397-22409 RB denotes specifically
T21019 22410-22417 VB denotes inhibit
T21020 22418-22423 JJ denotes STAT3
T21021 22424-22434 NN denotes activation
T21022 22435-22442 VBN denotes induced
T21023 22443-22445 IN denotes by
T21024 22446-22450 NN denotes IL-6
T21025 22451-22454 CC denotes but
T21026 22455-22458 RB denotes not
T21027 22459-22461 IN denotes by
T21028 22462-22467 NNP denotes IL-10
T21029 22467-22468 , denotes ,
T21030 22469-22476 RB denotes thereby
T21031 22477-22487 VBG denotes regulating
T21032 22488-22491 DT denotes the
T21033 22492-22501 JJ denotes divergent
T21034 22502-22508 NN denotes action
T21035 22509-22511 IN denotes of
T21036 22512-22516 NNP denotes IL-6
T21037 22517-22520 CC denotes and
T21038 22521-22526 NNP denotes IL-10
T21039 22527-22528 NNP denotes [
T21040 22528-22531 CD denotes 8,9
T21041 22531-22532 NNP denotes ]
T21042 22532-22533 . denotes .
T21043 22534-22536 IN denotes On
T21044 22537-22540 DT denotes the
T21045 22541-22549 NN denotes contrary
T21046 22549-22550 , denotes ,
T21047 22551-22556 NNP denotes SOCS1
T21048 22557-22559 VBZ denotes is
T21049 22560-22564 JJ denotes able
T21050 22565-22567 TO denotes to
T21051 22568-22577 RB denotes partially
T21052 22578-22585 VB denotes inhibit
T21053 22586-22600 JJ denotes IL-10-mediated
T21054 22601-22606 CD denotes STAT3
T21055 22607-22617 NN denotes activation
T21056 22618-22621 CC denotes and
T21057 22622-22630 JJ denotes cellular
T21058 22631-22640 NNS denotes responses
T21059 22640-22641 , denotes ,
T21060 22642-22644 RB denotes as
T21061 22645-22649 RB denotes well
T21062 22650-22652 IN denotes as
T21063 22653-22667 JJ denotes IFN-γ-mediated
T21064 22668-22673 CD denotes STAT1
T21065 22674-22684 NN denotes activation
T21066 22685-22686 NNP denotes [
T21067 22686-22688 CD denotes 32
T21068 22688-22689 NNP denotes ]
T21069 22689-22690 . denotes .
T21070 22691-22693 TO denotes To
T21071 22694-22703 VB denotes determine
T21072 22704-22711 IN denotes whether
T21073 22712-22717 NNS denotes SOCSs
T21074 22718-22722 VBD denotes were
T21075 22723-22731 VBN denotes involved
T21076 22732-22734 IN denotes in
T21077 22735-22738 DT denotes the
T21078 22739-22748 JJ denotes defective
T21079 22749-22762 JJ denotes IL-10-induced
T21080 22763-22768 CD denotes STAT3
T21081 22769-22779 NN denotes activation
T21082 22780-22782 IN denotes of
T21083 22783-22785 NNP denotes RA
T21084 22786-22789 NNP denotes CD4
T21085 22789-22790 VBD denotes +
T21086 22791-22792 NNP denotes T
T21087 22793-22798 NNS denotes cells
T21088 22798-22799 , denotes ,
T21089 22800-22803 DT denotes the
T21090 22804-22810 NNS denotes levels
T21091 22811-22813 IN denotes of
T21092 22814-22819 NNP denotes SOCS1
T21093 22820-22823 CC denotes and
T21094 22824-22829 NNP denotes SOCS3
T21095 22830-22834 NNP denotes mRNA
T21096 22835-22845 NN denotes expression
T21097 22846-22848 IN denotes in
T21098 22849-22851 NNP denotes PB
T21099 22852-22855 NNP denotes CD4
T21100 22855-22856 VBD denotes +
T21101 22857-22858 NNP denotes T
T21102 22859-22864 NNS denotes cells
T21103 22865-22869 IN denotes from
T21104 22870-22876 JJ denotes active
T21105 22877-22879 NNP denotes RA
T21106 22880-22888 NNS denotes patients
T21107 22889-22892 CC denotes and
T21108 22893-22897 IN denotes from
T21109 22898-22905 JJ denotes healthy
T21110 22906-22914 NNS denotes controls
T21111 22915-22919 VBD denotes were
T21112 22920-22928 VBN denotes compared
T21113 22929-22931 IN denotes by
T21114 22932-22948 JJ denotes semiquantitative
T21115 22949-22958 JJ denotes real-time
T21116 22959-22962 NNP denotes PCR
T21117 22962-22963 . denotes .
T21118 22964-22967 DT denotes The
T21119 22968-22970 NNP denotes RA
T21120 22971-22974 NNP denotes CD4
T21121 22974-22975 VBD denotes +
T21122 22976-22977 NNP denotes T
T21123 22978-22983 NNS denotes cells
T21124 22984-22993 VBD denotes contained
T21125 22994-23000 JJR denotes higher
T21126 23001-23007 NNS denotes levels
T21127 23008-23010 IN denotes of
T21128 23011-23016 CD denotes SOCS1
T21129 23017-23020 CC denotes but
T21130 23021-23026 JJR denotes lower
T21131 23027-23033 NNS denotes levels
T21132 23034-23036 IN denotes of
T21133 23037-23042 CD denotes SOCS3
T21134 23043-23054 NNS denotes transcripts
T21135 23055-23059 IN denotes than
T21136 23060-23063 VBD denotes did
T21137 23064-23071 VB denotes control
T21138 23072-23075 NNP denotes CD4
T21139 23075-23076 CD denotes +
T21140 23077-23078 NNP denotes T
T21141 23079-23084 NNS denotes cells
T21142 23085-23086 -LRB- denotes (
T21143 23086-23090 NNP denotes Fig.
T21144 23091-23093 CD denotes 6a
T21145 23093-23094 -RRB- denotes )
T21146 23094-23095 . denotes .
T21147 23096-23108 JJ denotes Constitutive
T21148 23109-23119 NN denotes expression
T21149 23120-23122 IN denotes of
T21150 23123-23128 CD denotes SOCS1
T21151 23129-23133 NNP denotes mRNA
T21152 23134-23136 IN denotes in
T21153 23137-23139 NNP denotes RA
T21154 23140-23143 NNP denotes CD4
T21155 23143-23144 VBD denotes +
T21156 23145-23146 NNP denotes T
T21157 23147-23152 NNS denotes cells
T21158 23153-23156 VBD denotes was
T21159 23157-23167 JJ denotes comparable
T21160 23168-23172 IN denotes with
T21161 23173-23176 DT denotes the
T21162 23177-23187 NN denotes expression
T21163 23188-23190 IN denotes in
T21164 23191-23197 JJ denotes normal
T21165 23198-23201 NNP denotes CD4
T21166 23201-23202 CD denotes +
T21167 23203-23204 NNP denotes T
T21168 23205-23210 NNS denotes cells
T21169 23211-23221 VBN denotes stimulated
T21170 23222-23224 IN denotes by
T21171 23225-23227 CD denotes 10
T21172 23228-23233 NN denotes ng/ml
T21173 23234-23238 NN denotes IL-6
T21174 23239-23240 -LRB- denotes (
T21175 23240-23244 NNP denotes Fig.
T21176 23245-23247 CD denotes 6b
T21177 23247-23248 -RRB- denotes )
T21178 23248-23249 , denotes ,
T21179 23250-23260 VBG denotes supporting
T21180 23261-23264 PRP$ denotes its
T21181 23265-23275 JJ denotes functional
T21182 23276-23288 NN denotes significance
T21183 23288-23289 . denotes .
T21184 23290-23299 JJ denotes Defective
T21185 23300-23313 JJ denotes IL-10-induced
T21186 23314-23319 CD denotes STAT3
T21187 23320-23330 NN denotes activation
T21188 23331-23340 RB denotes therefore
T21189 23341-23348 VBZ denotes appears
T21190 23349-23351 TO denotes to
T21191 23352-23354 VB denotes be
T21192 23355-23358 JJ denotes due
T21193 23359-23361 IN denotes at
T21194 23362-23367 JJS denotes least
T21195 23368-23370 IN denotes in
T21196 23371-23375 NN denotes part
T21197 23376-23378 TO denotes to
T21198 23379-23381 DT denotes an
T21199 23382-23391 NN denotes abundance
T21200 23392-23394 IN denotes of
T21201 23395-23400 CD denotes SOCS1
T21202 23401-23403 IN denotes in
T21203 23404-23406 NNP denotes RA
T21204 23407-23410 NNP denotes CD4
T21205 23410-23411 VBD denotes +
T21206 23412-23413 NNP denotes T
T21207 23414-23419 NNS denotes cells
T21208 23419-23420 . denotes .
T26799 23433-23436 CD denotes CD4
T26800 23436-23437 CD denotes +
T26801 23438-23439 NNP denotes T
T26802 23440-23445 NNS denotes cells
T26803 23446-23457 VBP denotes orchestrate
T26804 23458-23461 DT denotes the
T26805 23462-23470 JJ denotes Th1-type
T26806 23471-23484 JJ denotes cell-mediated
T26807 23485-23491 JJ denotes immune
T26808 23492-23500 NN denotes response
T26809 23501-23503 IN denotes in
T26810 23504-23506 NNP denotes RA
T26811 23507-23508 NNP denotes [
T26812 23508-23510 CD denotes 22
T26813 23510-23511 NNP denotes ]
T26814 23511-23512 . denotes .
T26815 23513-23522 VBN denotes Activated
T26816 23523-23526 NNP denotes CD4
T26817 23526-23527 CD denotes +
T26818 23528-23529 NNP denotes T
T26819 23530-23535 NNS denotes cells
T26820 23536-23545 VBP denotes stimulate
T26821 23546-23557 NNS denotes macrophages
T26822 23557-23558 , denotes ,
T26823 23559-23567 JJ denotes synovial
T26824 23568-23579 NNS denotes fibroblasts
T26825 23579-23580 , denotes ,
T26826 23581-23582 NNP denotes B
T26827 23583-23588 NNS denotes cells
T26828 23588-23589 , denotes ,
T26829 23590-23593 CC denotes and
T26830 23594-23605 NNS denotes osteoclasts
T26831 23606-23613 IN denotes through
T26832 23614-23617 DT denotes the
T26833 23618-23628 NN denotes expression
T26834 23629-23631 IN denotes of
T26835 23632-23636 NN denotes cell
T26836 23637-23644 NN denotes surface
T26837 23645-23654 NNS denotes molecules
T26838 23655-23658 CC denotes and
T26839 23659-23662 JJ denotes Th1
T26840 23663-23672 NNS denotes cytokines
T26841 23672-23673 , denotes ,
T26842 23674-23681 RB denotes thereby
T26843 23682-23694 VBG denotes contributing
T26844 23695-23697 TO denotes to
T26845 23698-23702 DT denotes both
T26846 23703-23706 DT denotes the
T26847 23707-23714 NN denotes chronic
T26848 23715-23727 NN denotes inflammation
T26849 23728-23731 CC denotes and
T26850 23732-23735 DT denotes the
T26851 23736-23741 JJ denotes joint
T26852 23742-23753 NN denotes destruction
T26853 23753-23754 . denotes .
T26854 23755-23758 CD denotes CD4
T26855 23758-23759 CD denotes +
T26856 23760-23761 NNP denotes T
T26857 23762-23767 NNS denotes cells
T26858 23768-23775 VBP denotes require
T26859 23776-23779 CD denotes two
T26860 23780-23787 NNS denotes signals
T26861 23788-23790 TO denotes to
T26862 23791-23793 VB denotes be
T26863 23794-23803 VBN denotes activated
T26864 23803-23804 : denotes ;
T26865 23805-23812 NN denotes antigen
T26866 23813-23821 NN denotes receptor
T26867 23822-23831 NN denotes occupancy
T26868 23832-23835 CC denotes and
T26869 23836-23849 JJ denotes CD28-mediated
T26870 23850-23863 NN denotes costimulation
T26871 23863-23864 . denotes .
T26872 23865-23867 IN denotes In
T26873 23868-23871 DT denotes the
T26874 23872-23874 NNP denotes ST
T26875 23875-23881 NN denotes lesion
T26876 23881-23882 , denotes ,
T26877 23883-23886 DT denotes the
T26878 23887-23891 NNP denotes CD28
T26879 23892-23899 NNS denotes ligands
T26880 23899-23900 , denotes ,
T26881 23901-23905 DT denotes both
T26882 23906-23910 NNP denotes CD80
T26883 23911-23914 CC denotes and
T26884 23915-23919 NNP denotes CD86
T26885 23919-23920 , denotes ,
T26886 23921-23929 RB denotes together
T26887 23930-23934 IN denotes with
T26888 23935-23938 NNP denotes MHC
T26889 23939-23944 NN denotes class
T26890 23945-23947 NNP denotes II
T26891 23948-23956 NNS denotes antigens
T26892 23956-23957 , denotes ,
T26893 23958-23961 VBP denotes are
T26894 23962-23975 RB denotes substantially
T26895 23976-23985 VBN denotes expressed
T26896 23986-23988 IN denotes by
T26897 23989-24007 JJ denotes antigen-presenting
T26898 24008-24013 NNS denotes cells
T26899 24014-24018 JJ denotes such
T26900 24019-24021 IN denotes as
T26901 24022-24033 NNS denotes macrophages
T26902 24034-24037 CC denotes and
T26903 24038-24047 JJ denotes dendritic
T26904 24048-24053 NNS denotes cells
T26905 24054-24055 NNP denotes [
T26906 24055-24060 CD denotes 18-20
T26907 24060-24061 NNP denotes ]
T26908 24061-24062 . denotes .
T26909 24063-24066 DT denotes The
T26910 24067-24079 NN denotes significance
T26911 24080-24082 IN denotes of
T26912 24083-24087 CD denotes CD28
T26913 24088-24098 NN denotes engagement
T26914 24099-24101 IN denotes in
T26915 24102-24105 DT denotes the
T26916 24106-24121 JJ denotes T-cell-mediated
T26917 24122-24129 NN denotes disease
T26918 24130-24137 NN denotes process
T26919 24138-24141 VBZ denotes has
T26920 24142-24150 RB denotes recently
T26921 24151-24155 VBN denotes been
T26922 24156-24162 VBN denotes proven
T26923 24163-24165 IN denotes by
T26924 24166-24169 DT denotes the
T26925 24170-24178 JJ denotes clinical
T26926 24179-24187 NN denotes efficacy
T26927 24188-24190 IN denotes of
T26928 24191-24194 PRP$ denotes its
T26929 24195-24202 NN denotes blocker
T26930 24203-24212 JJ denotes cytotoxic
T26931 24213-24230 JJ denotes T-cell-associated
T26932 24231-24238 NN denotes antigen
T26933 24239-24240 CD denotes 4
T26934 24241-24242 -LRB- denotes (
T26935 24242-24247 NN denotes CD152
T26936 24247-24248 -RRB- denotes )
T26937 24248-24249 : denotes -
T26938 24249-24252 NNP denotes IgG
T26939 24253-24255 IN denotes in
T26940 24256-24258 NNP denotes RA
T26941 24259-24267 NNS denotes patients
T26942 24268-24269 NNP denotes [
T26943 24269-24271 CD denotes 23
T26944 24271-24272 NNP denotes ]
T26945 24272-24273 . denotes .
T26946 24274-24279 NN denotes IL-10
T26947 24280-24285 VBZ denotes plays
T26948 24286-24287 DT denotes a
T26949 24288-24299 JJ denotes predominant
T26950 24300-24304 NN denotes role
T26951 24305-24307 IN denotes in
T26952 24308-24316 VBG denotes limiting
T26953 24317-24323 JJ denotes immune
T26954 24324-24327 CC denotes and
T26955 24328-24340 JJ denotes inflammatory
T26956 24341-24350 NNS denotes responses
T26957 24351-24353 IN denotes by
T26958 24354-24364 VBG denotes regulating
T26959 24365-24368 DT denotes the
T26960 24369-24377 NN denotes function
T26961 24378-24380 IN denotes of
T26962 24381-24385 DT denotes both
T26963 24386-24397 NNS denotes macrophages
T26964 24398-24401 CC denotes and
T26965 24402-24405 JJ denotes Th1
T26966 24406-24411 NNS denotes cells
T26967 24412-24413 VBP denotes [
T26968 24413-24414 CD denotes 1
T26969 24414-24415 NNP denotes ]
T26970 24415-24416 . denotes .
T26971 24417-24422 NN denotes IL-10
T26972 24423-24431 VBZ denotes inhibits
T26973 24432-24435 DT denotes the
T26974 24436-24444 NN denotes tyrosine
T26975 24445-24460 NN denotes phosphorylation
T26976 24461-24463 IN denotes of
T26977 24464-24467 DT denotes the
T26978 24468-24472 NNP denotes CD28
T26979 24473-24481 NN denotes molecule
T26980 24482-24485 CC denotes and
T26981 24486-24489 DT denotes the
T26982 24490-24500 JJ denotes subsequent
T26983 24501-24521 NN denotes phosphatidylinositol
T26984 24522-24530 JJ denotes 3-kinase
T26985 24531-24538 JJ denotes binding
T26986 24539-24541 IN denotes in
T26987 24542-24543 NNP denotes T
T26988 24544-24549 NNS denotes cells
T26989 24549-24550 , denotes ,
T26990 24551-24554 CC denotes and
T26991 24555-24562 RB denotes thereby
T26992 24563-24571 RB denotes directly
T26993 24572-24576 VBZ denotes acts
T26994 24577-24579 IN denotes on
T26995 24580-24581 NNP denotes T
T26996 24582-24587 NNS denotes cells
T26997 24588-24589 NNP denotes [
T26998 24589-24591 CD denotes 24
T26999 24591-24592 NNP denotes ]
T27000 24592-24593 . denotes .
T27001 24594-24596 IN denotes In
T27002 24597-24600 DT denotes the
T27003 24601-24608 JJ denotes present
T27004 24609-24614 NN denotes study
T27005 24614-24615 , denotes ,
T27006 24616-24618 PRP denotes we
T27007 24619-24624 VBD denotes found
T27008 24625-24629 IN denotes that
T27009 24630-24632 NNP denotes PB
T27010 24633-24636 NNP denotes CD4
T27011 24636-24637 VBD denotes +
T27012 24638-24639 NNP denotes T
T27013 24640-24645 NNS denotes cells
T27014 24646-24650 IN denotes from
T27015 24651-24659 NNS denotes patients
T27016 24660-24664 IN denotes with
T27017 24665-24671 JJ denotes active
T27018 24672-24674 NNP denotes RA
T27019 24674-24675 , denotes ,
T27020 24676-24678 IN denotes in
T27021 24679-24682 DT denotes the
T27022 24683-24691 NN denotes presence
T27023 24692-24694 IN denotes of
T27024 24695-24700 NNP denotes IL-10
T27025 24700-24701 , denotes ,
T27026 24702-24705 VBP denotes are
T27027 24706-24710 JJ denotes able
T27028 24711-24713 TO denotes to
T27029 24714-24721 VB denotes produce
T27030 24722-24728 JJR denotes higher
T27031 24729-24735 NNS denotes levels
T27032 24736-24738 IN denotes of
T27033 24739-24744 JJ denotes IFN-γ
T27034 24745-24750 IN denotes after
T27035 24751-24754 NNP denotes CD3
T27036 24755-24758 CC denotes and
T27037 24759-24763 NNP denotes CD28
T27038 24764-24777 NN denotes costimulation
T27039 24778-24782 IN denotes than
T27040 24783-24789 JJ denotes normal
T27041 24790-24793 NNP denotes CD4
T27042 24793-24794 CD denotes +
T27043 24795-24796 NNP denotes T
T27044 24797-24802 NNS denotes cells
T27045 24802-24803 . denotes .
T27046 24804-24811 IN denotes Despite
T27047 24812-24822 JJ denotes high-level
T27048 24823-24830 NN denotes IL-10R1
T27049 24831-24841 NN denotes expression
T27050 24842-24845 CC denotes and
T27051 24846-24858 JJ denotes constitutive
T27052 24859-24864 CD denotes STAT3
T27053 24865-24875 NN denotes activation
T27054 24875-24876 , denotes ,
T27055 24877-24890 JJ denotes IL-10-induced
T27056 24891-24899 NN denotes tyrosine
T27057 24900-24915 NN denotes phosphorylation
T27058 24916-24918 IN denotes of
T27059 24919-24924 CD denotes STAT3
T27060 24925-24927 VBZ denotes is
T27061 24928-24938 VBN denotes suppressed
T27062 24939-24941 IN denotes in
T27063 24942-24944 NNP denotes RA
T27064 24945-24948 NNP denotes CD4
T27065 24948-24949 VBD denotes +
T27066 24950-24951 NNP denotes T
T27067 24952-24957 NNS denotes cells
T27068 24957-24958 , denotes ,
T27069 24959-24961 IN denotes in
T27070 24962-24970 NN denotes contrast
T27071 24971-24973 TO denotes to
T27072 24974-24980 JJ denotes normal
T27073 24981-24984 NNP denotes CD4
T27074 24984-24985 CD denotes +
T27075 24986-24987 NNP denotes T
T27076 24988-24993 NNS denotes cells
T27077 24993-24994 , denotes ,
T27078 24995-25000 WRB denotes where
T27079 25001-25006 NNP denotes STAT3
T27080 25007-25022 NN denotes phosphorylation
T27081 25023-25025 VBZ denotes is
T27082 25026-25042 RB denotes dose-dependently
T27083 25043-25052 JJ denotes inducible
T27084 25053-25055 IN denotes by
T27085 25056-25061 NNP denotes IL-10
T27086 25061-25062 . denotes .
T27087 25063-25068 NNP denotes Serum
T27088 25069-25073 NNP denotes IL-6
T27089 25074-25078 IN denotes from
T27090 25079-25081 NNP denotes RA
T27091 25082-25090 NNS denotes patients
T27092 25091-25098 VBZ denotes induces
T27093 25099-25104 CD denotes STAT3
T27094 25105-25108 CC denotes but
T27095 25109-25112 RB denotes not
T27096 25113-25118 CD denotes STAT1
T27097 25119-25134 NN denotes phosphorylation
T27098 25135-25137 IN denotes in
T27099 25138-25144 JJ denotes normal
T27100 25145-25148 NNP denotes CD4
T27101 25148-25149 CD denotes +
T27102 25150-25151 NNP denotes T
T27103 25152-25157 NNS denotes cells
T27104 25157-25158 , denotes ,
T27105 25159-25162 CC denotes and
T27106 25163-25172 JJ denotes exogenous
T27107 25173-25177 NN denotes IL-6
T27108 25178-25185 VBZ denotes induces
T27109 25186-25189 DT denotes the
T27110 25190-25200 NN denotes resistance
T27111 25201-25203 TO denotes to
T27112 25204-25209 NNP denotes IL-10
T27113 25210-25220 NN denotes inhibition
T27114 25221-25223 IN denotes of
T27115 25224-25229 JJ denotes IFN-γ
T27116 25230-25240 NN denotes production
T27117 25240-25241 . denotes .
T27118 25242-25244 NNP denotes RA
T27119 25245-25248 NNP denotes CD4
T27120 25248-25249 VBD denotes +
T27121 25250-25251 NNP denotes T
T27122 25252-25257 NNS denotes cells
T27123 25258-25265 VBP denotes contain
T27124 25266-25272 JJR denotes higher
T27125 25273-25279 NNS denotes levels
T27126 25280-25282 IN denotes of
T27127 25283-25288 CD denotes SOCS1
T27128 25289-25292 CC denotes but
T27129 25293-25300 VBP denotes contain
T27130 25301-25306 JJR denotes lower
T27131 25307-25313 NNS denotes levels
T27132 25314-25316 IN denotes of
T27133 25317-25322 CD denotes SOCS3
T27134 25323-25334 NNS denotes transcripts
T27135 25335-25337 IN denotes in
T27136 25338-25348 NN denotes comparison
T27137 25349-25353 IN denotes with
T27138 25354-25360 JJ denotes normal
T27139 25361-25364 NNP denotes CD4
T27140 25364-25365 CD denotes +
T27141 25366-25367 NNP denotes T
T27142 25368-25373 NNS denotes cells
T27143 25373-25374 . denotes .
T27144 25375-25380 DT denotes These
T27145 25381-25389 NNS denotes findings
T27146 25390-25398 VBP denotes indicate
T27147 25399-25403 IN denotes that
T27148 25404-25407 CD denotes CD4
T27149 25407-25408 CD denotes +
T27150 25409-25410 NNP denotes T
T27151 25411-25416 NNS denotes cells
T27152 25417-25423 VBP denotes become
T27153 25424-25433 JJ denotes resistant
T27154 25434-25436 TO denotes to
T27155 25437-25440 DT denotes the
T27156 25441-25451 JJ denotes inhibitory
T27157 25452-25458 NN denotes effect
T27158 25459-25461 IN denotes of
T27159 25462-25467 NN denotes IL-10
T27160 25468-25474 IN denotes before
T27161 25475-25484 NN denotes migration
T27162 25485-25489 IN denotes into
T27163 25490-25493 DT denotes the
T27164 25494-25502 JJ denotes inflamed
T27165 25503-25505 NNP denotes ST
T27166 25505-25506 , denotes ,
T27167 25507-25510 CC denotes and
T27168 25511-25518 VBP denotes suggest
T27169 25519-25523 IN denotes that
T27170 25524-25528 DT denotes this
T27171 25529-25539 NN denotes resistance
T27172 25540-25543 MD denotes may
T27173 25544-25546 VB denotes be
T27174 25547-25559 JJ denotes attributable
T27175 25560-25562 TO denotes to
T27176 25563-25571 VBN denotes impaired
T27177 25572-25587 JJ denotes IL-10-dependent
T27178 25588-25593 CD denotes STAT3
T27179 25594-25604 NN denotes activation
T27180 25604-25605 , denotes ,
T27181 25606-25608 IN denotes in
T27182 25609-25620 NN denotes association
T27183 25621-25625 IN denotes with
T27184 25626-25635 VBN denotes sustained
T27185 25636-25641 NNP denotes STAT3
T27186 25642-25657 NN denotes phosphorylation
T27187 25658-25661 CC denotes and
T27188 25662-25667 CD denotes SOCS1
T27189 25668-25677 NN denotes induction
T27190 25677-25678 . denotes .
T27191 25679-25693 JJ denotes IL-10-mediated
T27192 25694-25704 NN denotes inhibition
T27193 25705-25707 IN denotes of
T27194 25708-25711 NNP denotes CD4
T27195 25711-25712 NNP denotes +
T27196 25713-25719 NNP denotes T-cell
T27197 25720-25728 NN denotes cytokine
T27198 25729-25739 NN denotes production
T27199 25740-25742 VBZ denotes is
T27200 25743-25754 RB denotes principally
T27201 25755-25764 JJ denotes dependent
T27202 25765-25767 IN denotes on
T27203 25768-25771 PRP$ denotes its
T27204 25772-25782 NN denotes inhibition
T27205 25783-25785 IN denotes of
T27206 25786-25796 NN denotes macrophage
T27207 25797-25815 JJ denotes antigen-presenting
T27208 25816-25820 NN denotes cell
T27209 25821-25829 NN denotes function
T27210 25830-25831 NNP denotes [
T27211 25831-25832 CD denotes 1
T27212 25832-25833 NNP denotes ]
T27213 25833-25834 . denotes .
T27214 25835-25842 RB denotes However
T27215 25842-25843 , denotes ,
T27216 25844-25848 DT denotes this
T27217 25849-25857 JJ denotes indirect
T27218 25858-25868 JJ denotes inhibitory
T27219 25869-25875 NN denotes effect
T27220 25876-25878 VBZ denotes is
T27221 25879-25886 VBN denotes thought
T27222 25887-25889 TO denotes to
T27223 25890-25892 VB denotes be
T27224 25893-25903 VBN denotes restricted
T27225 25904-25906 IN denotes at
T27226 25907-25910 DT denotes the
T27227 25911-25915 NN denotes site
T27228 25916-25918 IN denotes of
T27229 25919-25925 NNP denotes T-cell
T27230 25926-25936 NN denotes activation
T27231 25937-25939 IN denotes in
T27232 25940-25942 NNP denotes RA
T27233 25942-25943 , denotes ,
T27234 25944-25951 IN denotes because
T27235 25952-25963 NNS denotes macrophages
T27236 25964-25966 IN denotes in
T27237 25967-25970 DT denotes the
T27238 25971-25973 NNP denotes ST
T27239 25974-25981 VB denotes express
T27240 25982-25986 JJ denotes high
T27241 25987-25993 NNS denotes levels
T27242 25994-25996 IN denotes of
T27243 25997-26006 NNS denotes cytokines
T27244 26006-26007 , denotes ,
T27245 26008-26012 NNP denotes CD80
T27246 26013-26016 CC denotes and
T27247 26017-26021 NNP denotes CD86
T27248 26022-26031 NNS denotes molecules
T27249 26031-26032 , denotes ,
T27250 26033-26036 CC denotes and
T27251 26037-26040 NNP denotes MHC
T27252 26041-26046 NN denotes class
T27253 26047-26049 NNP denotes II
T27254 26050-26058 VBZ denotes antigens
T27255 26059-26060 NNP denotes [
T27256 26060-26068 CD denotes 10,18-20
T27257 26068-26069 NNP denotes ]
T27258 26069-26070 . denotes .
T27259 26071-26075 RBR denotes More
T27260 26076-26084 RB denotes recently
T27261 26084-26085 , denotes ,
T27262 26086-26091 NNP denotes IL-10
T27263 26092-26095 VBZ denotes has
T27264 26096-26100 VBN denotes been
T27265 26101-26106 VBN denotes shown
T27266 26107-26109 TO denotes to
T27267 26110-26116 VB denotes induce
T27268 26117-26120 DT denotes the
T27269 26121-26137 JJ denotes antigen-specific
T27270 26138-26144 NN denotes T-cell
T27271 26145-26161 NN denotes unresponsiveness
T27272 26162-26164 IN denotes by
T27273 26165-26175 VBG denotes inhibiting
T27274 26176-26180 NNP denotes CD28
T27275 26181-26189 NN denotes tyrosine
T27276 26190-26205 NN denotes phosphorylation
T27277 26206-26207 NNP denotes [
T27278 26207-26209 CD denotes 33
T27279 26209-26210 NNP denotes ]
T27280 26210-26211 . denotes .
T27281 26212-26216 DT denotes This
T27282 26217-26223 JJ denotes direct
T27283 26224-26230 NN denotes effect
T27284 26231-26235 RB denotes also
T27285 26236-26239 MD denotes may
T27286 26240-26242 VB denotes be
T27287 26243-26250 VBN denotes limited
T27288 26251-26253 IN denotes in
T27289 26254-26260 JJ denotes active
T27290 26261-26263 NNP denotes RA
T27291 26264-26272 NNS denotes patients
T27292 26272-26273 , denotes ,
T27293 26274-26281 IN denotes because
T27294 26282-26287 PRP$ denotes their
T27295 26288-26290 NNP denotes PB
T27296 26291-26294 NNP denotes CD4
T27297 26294-26295 VBD denotes +
T27298 26296-26297 NNP denotes T
T27299 26298-26303 NNS denotes cells
T27300 26304-26310 VBD denotes showed
T27301 26311-26312 DT denotes a
T27302 26313-26322 JJ denotes defective
T27303 26323-26328 NN denotes IL-10
T27304 26329-26339 NN denotes inhibition
T27305 26340-26342 IN denotes of
T27306 26343-26360 JJ denotes CD28-costimulated
T27307 26361-26371 NN denotes production
T27308 26372-26374 IN denotes of
T27309 26375-26379 DT denotes both
T27310 26380-26385 NNP denotes IFN-γ
T27311 26386-26389 CC denotes and
T27312 26390-26394 NNP denotes IL-2
T27313 26394-26395 . denotes .
T27314 26396-26404 JJ denotes Numerous
T27315 26405-26414 NNS denotes cytokines
T27316 26414-26415 , denotes ,
T27317 26416-26420 DT denotes both
T27318 26421-26436 JJ denotes proinflammatory
T27319 26437-26440 CC denotes and
T27320 26441-26458 JJ denotes anti-inflammatory
T27321 26458-26459 , denotes ,
T27322 26460-26464 VBP denotes have
T27323 26465-26469 VBN denotes been
T27324 26470-26478 VBN denotes detected
T27325 26479-26481 IN denotes in
T27326 26482-26485 DT denotes the
T27327 26486-26488 NNP denotes ST
T27328 26489-26491 IN denotes of
T27329 26492-26494 NNP denotes RA
T27330 26494-26495 , denotes ,
T27331 26496-26499 CC denotes and
T27332 26500-26503 DT denotes the
T27333 26504-26511 NN denotes balance
T27334 26512-26519 IN denotes between
T27335 26520-26525 DT denotes these
T27336 26526-26534 VBG denotes opposing
T27337 26535-26543 NN denotes cytokine
T27338 26544-26554 NNS denotes activities
T27339 26555-26564 VBZ denotes regulates
T27340 26565-26572 NN denotes disease
T27341 26573-26581 NN denotes severity
T27342 26582-26583 NNP denotes [
T27343 26583-26585 CD denotes 10
T27344 26585-26586 NNP denotes ]
T27345 26586-26587 . denotes .
T27346 26588-26598 NNP denotes Endogenous
T27347 26599-26604 NNP denotes IL-10
T27348 26604-26605 , denotes ,
T27349 26606-26614 VBD denotes produced
T27350 26615-26621 RB denotes mainly
T27351 26622-26624 IN denotes by
T27352 26625-26636 NNS denotes macrophages
T27353 26637-26640 CC denotes and
T27354 26641-26642 NNP denotes T
T27355 26643-26648 NNS denotes cells
T27356 26648-26649 , denotes ,
T27357 26650-26658 VBZ denotes inhibits
T27358 26659-26674 JJ denotes proinflammatory
T27359 26675-26683 NN denotes cytokine
T27360 26684-26694 NN denotes production
T27361 26695-26697 IN denotes by
T27362 26698-26700 NNP denotes ST
T27363 26701-26706 NNS denotes cells
T27364 26707-26708 NNP denotes [
T27365 26708-26710 CD denotes 12
T27366 26710-26711 NNP denotes ]
T27367 26711-26712 . denotes .
T27368 26713-26720 RB denotes However
T27369 26720-26721 , denotes ,
T27370 26722-26726 DT denotes this
T27371 26727-26737 JJ denotes regulatory
T27372 26738-26746 NN denotes activity
T27373 26747-26752 VBZ denotes seems
T27374 26753-26755 TO denotes to
T27375 26756-26758 VB denotes be
T27376 26759-26769 VBN denotes restricted
T27377 26770-26776 IN denotes during
T27378 26777-26784 JJ denotes chronic
T27379 26785-26797 NN denotes inflammation
T27380 26797-26798 . denotes .
T27381 26799-26802 DT denotes The
T27382 26803-26813 NN denotes activation
T27383 26814-26816 IN denotes of
T27384 26817-26821 DT denotes both
T27385 26822-26825 DT denotes the
T27386 26826-26839 JJ denotes extracellular
T27387 26840-26858 JJ denotes stimulus-regulated
T27388 26859-26865 NN denotes kinase
T27389 26866-26869 CC denotes and
T27390 26870-26873 JJ denotes p38
T27391 26874-26880 NN denotes kinase
T27392 26881-26889 NNS denotes pathways
T27393 26889-26890 , denotes ,
T27394 26891-26898 VBN denotes induced
T27395 26899-26901 IN denotes by
T27396 26902-26907 NNP denotes TNF-α
T27397 26908-26911 CC denotes and
T27398 26912-26916 NNP denotes IL-1
T27399 26916-26917 , denotes ,
T27400 26918-26926 VBZ denotes inhibits
T27401 26927-26930 DT denotes the
T27402 26931-26935 NN denotes Jak1
T27403 26936-26941 CD denotes STAT3
T27404 26942-26951 VBG denotes signaling
T27405 26952-26959 NN denotes pathway
T27406 26960-26966 VBN denotes shared
T27407 26967-26969 IN denotes by
T27408 26970-26975 NNP denotes IL-10
T27409 26976-26979 CC denotes and
T27410 26980-26984 NNP denotes IL-6
T27411 26985-26987 IN denotes in
T27412 26988-26995 JJ denotes adhered
T27413 26996-27007 NNS denotes macrophages
T27414 27008-27009 NNP denotes [
T27415 27009-27011 CD denotes 13
T27416 27011-27012 NNP denotes ]
T27417 27012-27013 . denotes .
T27418 27014-27018 RBR denotes More
T27419 27019-27030 RB denotes importantly
T27420 27030-27031 , denotes ,
T27421 27032-27046 JJ denotes IL-10-mediated
T27422 27047-27052 CD denotes STAT3
T27423 27053-27063 NN denotes activation
T27424 27064-27066 VBZ denotes is
T27425 27067-27073 RB denotes mostly
T27426 27074-27086 JJ denotes undetectable
T27427 27087-27089 IN denotes in
T27428 27090-27092 NNP denotes RA
T27429 27093-27101 JJ denotes synovial
T27430 27102-27113 NNS denotes macrophages
T27431 27113-27114 . denotes .
T27432 27115-27119 DT denotes This
T27433 27120-27128 VBN denotes impaired
T27434 27129-27134 NN denotes IL-10
T27435 27135-27144 VBG denotes signaling
T27436 27145-27147 VBZ denotes is
T27437 27148-27156 RB denotes probably
T27438 27157-27164 VBN denotes induced
T27439 27165-27167 IN denotes by
T27440 27168-27175 JJ denotes chronic
T27441 27176-27184 NN denotes exposure
T27442 27185-27187 TO denotes to
T27443 27188-27194 JJ denotes immune
T27444 27195-27204 NNS denotes complexes
T27445 27205-27207 IN denotes in
T27446 27208-27212 NN denotes vivo
T27447 27212-27213 , denotes ,
T27448 27214-27221 IN denotes because
T27449 27222-27226 DT denotes both
T27450 27227-27231 NN denotes cell
T27451 27232-27239 NN denotes surface
T27452 27240-27247 NN denotes IL-10R1
T27453 27248-27258 NN denotes expression
T27454 27259-27262 CC denotes and
T27455 27263-27276 JJ denotes IL-10-induced
T27456 27277-27281 JJ denotes Jak1
T27457 27282-27292 NN denotes activation
T27458 27293-27296 VBP denotes are
T27459 27297-27307 VBN denotes suppressed
T27460 27308-27310 IN denotes in
T27461 27311-27323 JJ denotes IFN-γ-primed
T27462 27324-27335 NNS denotes macrophages
T27463 27336-27338 IN denotes by
T27464 27339-27340 DT denotes a
T27465 27341-27348 NN denotes protein
T27466 27349-27355 NN denotes kinase
T27467 27356-27367 JJ denotes C-dependent
T27468 27368-27375 NN denotes pathway
T27469 27376-27385 VBG denotes following
T27470 27386-27394 NN denotes ligation
T27471 27395-27397 IN denotes of
T27472 27398-27401 DT denotes the
T27473 27402-27405 NNP denotes IgG
T27474 27406-27408 NNP denotes Fc
T27475 27409-27414 NN denotes gamma
T27476 27415-27423 NN denotes receptor
T27477 27424-27425 NNP denotes [
T27478 27425-27427 CD denotes 14
T27479 27427-27428 NNP denotes ]
T27480 27428-27429 . denotes .
T27481 27430-27441 RB denotes Furthermore
T27482 27441-27442 , denotes ,
T27483 27443-27452 JJ denotes dendritic
T27484 27453-27458 NNS denotes cells
T27485 27459-27463 IN denotes from
T27486 27464-27466 NNP denotes RA
T27487 27467-27475 JJ denotes synovial
T27488 27476-27482 NNS denotes fluids
T27489 27483-27486 VBP denotes are
T27490 27487-27496 JJ denotes resistant
T27491 27497-27499 TO denotes to
T27492 27500-27503 DT denotes the
T27493 27504-27520 JJ denotes immunoregulatory
T27494 27521-27527 NN denotes effect
T27495 27528-27530 IN denotes of
T27496 27531-27536 NNP denotes IL-10
T27497 27537-27540 JJ denotes due
T27498 27541-27543 TO denotes to
T27499 27544-27553 VBN denotes decreased
T27500 27554-27563 NN denotes transport
T27501 27564-27566 IN denotes of
T27502 27567-27580 JJ denotes intracellular
T27503 27581-27588 NN denotes IL-10R1
T27504 27589-27591 IN denotes in
T27505 27592-27595 DT denotes the
T27506 27596-27604 NN denotes presence
T27507 27605-27607 IN denotes of
T27508 27608-27623 JJ denotes proinflammatory
T27509 27624-27632 NN denotes cytokine
T27510 27633-27640 NNS denotes stimuli
T27511 27641-27645 JJ denotes such
T27512 27646-27648 IN denotes as
T27513 27649-27654 NNP denotes TNF-α
T27514 27654-27655 , denotes ,
T27515 27656-27660 NNP denotes IL-1
T27516 27660-27661 , denotes ,
T27517 27662-27665 CC denotes and
T27518 27666-27677 NN denotes granulocyte
T27519 27678-27688 NN denotes macrophage
T27520 27689-27707 JJ denotes colony-stimulating
T27521 27708-27714 NN denotes factor
T27522 27715-27716 NNP denotes [
T27523 27716-27718 CD denotes 15
T27524 27718-27719 NNP denotes ]
T27525 27719-27720 . denotes .
T27526 27721-27723 PRP denotes We
T27527 27724-27728 VBP denotes have
T27528 27729-27741 VBN denotes demonstrated
T27529 27742-27746 IN denotes that
T27530 27747-27750 DT denotes the
T27531 27751-27761 NN denotes resistance
T27532 27762-27764 IN denotes of
T27533 27765-27767 NNP denotes RA
T27534 27768-27771 NNP denotes CD4
T27535 27771-27772 VBD denotes +
T27536 27773-27774 NNP denotes T
T27537 27775-27780 NNS denotes cells
T27538 27781-27783 TO denotes to
T27539 27784-27789 NNP denotes IL-10
T27540 27790-27793 MD denotes may
T27541 27794-27796 VB denotes be
T27542 27797-27807 VBN denotes associated
T27543 27808-27812 IN denotes with
T27544 27813-27822 JJ denotes defective
T27545 27823-27838 JJ denotes IL-10-dependent
T27546 27839-27844 CD denotes STAT3
T27547 27845-27855 NN denotes activation
T27548 27855-27856 , denotes ,
T27549 27857-27860 CC denotes but
T27550 27861-27864 RB denotes not
T27551 27865-27869 IN denotes with
T27552 27870-27877 JJ denotes IL-10R1
T27553 27878-27888 NN denotes expression
T27554 27888-27889 . denotes .
T27555 27890-27900 NNP denotes Inhibitory
T27556 27901-27908 NNS denotes effects
T27557 27909-27911 IN denotes of
T27558 27912-27917 NN denotes IL-10
T27559 27918-27920 IN denotes on
T27560 27921-27926 DT denotes these
T27561 27927-27939 JJ denotes inflammatory
T27562 27940-27944 NN denotes cell
T27563 27945-27950 NNS denotes types
T27564 27951-27954 VBP denotes are
T27565 27955-27964 RB denotes therefore
T27566 27965-27979 RB denotes differentially
T27567 27980-27989 VBN denotes modulated
T27568 27990-27992 IN denotes at
T27569 27993-27996 DT denotes the
T27570 27997-28003 NN denotes signal
T27571 28004-28016 NN denotes transduction
T27572 28017-28022 NN denotes level
T27573 28023-28028 IN denotes under
T27574 28029-28032 DT denotes the
T27575 28033-28045 JJ denotes inflammatory
T27576 28046-28057 NN denotes environment
T27577 28058-28060 IN denotes in
T27578 28061-28063 NNP denotes RA
T27579 28063-28064 . denotes .
T27580 28065-28067 IN denotes In
T27581 28068-28079 NN denotes association
T27582 28080-28084 IN denotes with
T27583 28085-28093 JJ denotes impaired
T27584 28094-28108 JJ denotes IL-10-mediated
T27585 28109-28114 CD denotes STAT3
T27586 28115-28125 NN denotes activation
T27587 28125-28126 , denotes ,
T27588 28127-28132 NNP denotes STAT3
T27589 28133-28136 VBD denotes was
T27590 28137-28142 VBN denotes found
T27591 28143-28145 TO denotes to
T27592 28146-28148 VB denotes be
T27593 28149-28157 JJ denotes tyrosine
T27594 28158-28172 VBN denotes phosphorylated
T27595 28173-28185 RB denotes persistently
T27596 28186-28187 -LRB- denotes (
T27597 28187-28189 IN denotes up
T27598 28190-28192 TO denotes to
T27599 28193-28194 CD denotes 6
T27600 28195-28200 NNS denotes hours
T27601 28200-28201 -RRB- denotes )
T27602 28202-28204 IN denotes in
T27603 28205-28212 RB denotes freshly
T27604 28213-28221 VBN denotes isolated
T27605 28222-28224 NNP denotes PB
T27606 28225-28228 CC denotes and
T27607 28229-28231 NNP denotes ST
T27608 28232-28235 NNP denotes CD4
T27609 28235-28236 VBD denotes +
T27610 28237-28238 NNP denotes T
T27611 28239-28244 NNS denotes cells
T27612 28245-28249 IN denotes from
T27613 28250-28252 NNP denotes RA
T27614 28253-28261 NNS denotes patients
T27615 28261-28262 . denotes .
T27616 28263-28268 CD denotes STAT3
T27617 28269-28271 VBZ denotes is
T27618 28272-28281 VBN denotes activated
T27619 28282-28284 IN denotes by
T27620 28285-28286 DT denotes a
T27621 28287-28294 NN denotes variety
T27622 28295-28297 IN denotes of
T27623 28298-28307 NNS denotes cytokines
T27624 28307-28308 , denotes ,
T27625 28309-28316 RB denotes notably
T27626 28317-28320 DT denotes the
T27627 28321-28325 NNP denotes IL-6
T27628 28326-28332 NN denotes family
T27629 28333-28335 IN denotes of
T27630 28336-28345 NNS denotes cytokines
T27631 28346-28347 -LRB- denotes (
T27632 28347-28351 FW denotes e.g.
T27633 28352-28356 NN denotes IL-6
T27634 28356-28357 , denotes ,
T27635 28358-28363 NNP denotes IL-11
T27636 28363-28364 , denotes ,
T27637 28365-28373 NN denotes leukemia
T27638 28374-28384 JJ denotes inhibitory
T27639 28385-28391 NN denotes factor
T27640 28391-28392 , denotes ,
T27641 28393-28396 CC denotes and
T27642 28397-28407 NN denotes oncostatin
T27643 28408-28409 NNP denotes M
T27644 28409-28410 -RRB- denotes )
T27645 28411-28414 CC denotes and
T27646 28415-28421 NN denotes growth
T27647 28422-28429 NNS denotes factors
T27648 28429-28430 , denotes ,
T27649 28431-28433 IN denotes in
T27650 28434-28442 NN denotes addition
T27651 28443-28445 TO denotes to
T27652 28446-28451 NNP denotes IL-10
T27653 28452-28453 NNP denotes [
T27654 28453-28454 CD denotes 4
T27655 28454-28455 NNP denotes ]
T27656 28455-28456 . denotes .
T27657 28457-28459 IN denotes Of
T27658 28460-28465 DT denotes these
T27659 28466-28475 NNS denotes cytokines
T27660 28475-28476 , denotes ,
T27661 28477-28481 NN denotes IL-6
T27662 28482-28487 VBZ denotes plays
T27663 28488-28489 DT denotes a
T27664 28490-28501 JJ denotes predominant
T27665 28502-28506 NN denotes role
T27666 28507-28509 IN denotes in
T27667 28510-28519 VBG denotes eliciting
T27668 28520-28521 DT denotes a
T27669 28522-28530 JJ denotes systemic
T27670 28531-28539 NN denotes reaction
T27671 28540-28544 JJ denotes such
T27672 28545-28547 IN denotes as
T27673 28548-28551 DT denotes the
T27674 28552-28557 JJ denotes acute
T27675 28558-28563 NN denotes phase
T27676 28564-28572 NN denotes response
T27677 28573-28575 IN denotes in
T27678 28576-28582 JJ denotes active
T27679 28583-28585 NNP denotes RA
T27680 28585-28586 , denotes ,
T27681 28587-28590 JJ denotes due
T27682 28591-28597 RB denotes mainly
T27683 28598-28600 TO denotes to
T27684 28601-28604 PRP$ denotes its
T27685 28605-28614 NN denotes abundance
T27686 28615-28617 IN denotes in
T27687 28618-28621 DT denotes the
T27688 28622-28627 NN denotes blood
T27689 28628-28639 NN denotes circulation
T27690 28640-28641 NNP denotes [
T27691 28641-28643 CD denotes 27
T27692 28643-28644 NNP denotes ]
T27693 28644-28645 . denotes .
T27694 28646-28656 JJ denotes Consistent
T27695 28657-28661 IN denotes with
T27696 28662-28666 DT denotes this
T27697 28667-28673 NN denotes notion
T27698 28673-28674 , denotes ,
T27699 28675-28679 NN denotes IL-6
T27700 28680-28683 VBD denotes was
T27701 28684-28687 DT denotes the
T27702 28688-28693 JJ denotes major
T27703 28694-28710 JJ denotes STAT3-activating
T27704 28711-28717 NN denotes factor
T27705 28718-28727 VBN denotes contained
T27706 28728-28730 IN denotes in
T27707 28731-28734 DT denotes the
T27708 28735-28740 NN denotes serum
T27709 28741-28743 IN denotes of
T27710 28744-28750 JJ denotes active
T27711 28751-28753 NNP denotes RA
T27712 28754-28762 NNS denotes patients
T27713 28762-28763 , denotes ,
T27714 28764-28767 CC denotes and
T27715 28768-28771 DT denotes the
T27716 28772-28786 NN denotes responsiveness
T27717 28787-28789 TO denotes to
T27718 28790-28795 NNP denotes IL-10
T27719 28796-28799 VBD denotes was
T27720 28800-28810 VBN denotes suppressed
T27721 28811-28813 IN denotes in
T27722 28814-28820 JJ denotes normal
T27723 28821-28824 NNP denotes CD4
T27724 28824-28825 CD denotes +
T27725 28826-28827 NNP denotes T
T27726 28828-28833 NNS denotes cells
T27727 28834-28839 IN denotes after
T27728 28840-28842 CD denotes 36
T27729 28843-28848 NNS denotes hours
T27730 28849-28851 IN denotes of
T27731 28852-28862 NN denotes incubation
T27732 28863-28867 IN denotes with
T27733 28868-28872 NN denotes IL-6
T27734 28872-28873 . denotes .
T27735 28874-28879 DT denotes These
T27736 28880-28887 NNS denotes results
T27737 28888-28895 VBP denotes suggest
T27738 28896-28900 IN denotes that
T27739 28901-28905 DT denotes both
T27740 28906-28909 DT denotes the
T27741 28910-28919 VBN denotes sustained
T27742 28920-28925 CD denotes STAT3
T27743 28926-28936 NN denotes activation
T27744 28937-28940 CC denotes and
T27745 28941-28944 DT denotes the
T27746 28945-28955 NN denotes resistance
T27747 28956-28958 TO denotes to
T27748 28959-28964 NNP denotes IL-10
T27749 28965-28975 NN denotes inhibition
T27750 28976-28981 VBD denotes found
T27751 28982-28984 IN denotes in
T27752 28985-28987 NNP denotes RA
T27753 28988-28991 NNP denotes CD4
T27754 28991-28992 VBD denotes +
T27755 28993-28994 NNP denotes T
T27756 28995-29000 NNS denotes cells
T27757 29001-29004 MD denotes may
T27758 29005-29007 VB denotes be
T27759 29008-29015 VBN denotes induced
T27760 29016-29021 IN denotes after
T27761 29022-29029 JJ denotes chronic
T27762 29030-29038 NN denotes exposure
T27763 29039-29041 IN denotes in
T27764 29042-29046 NN denotes vivo
T27765 29047-29049 TO denotes to
T27766 29050-29054 JJ denotes high
T27767 29055-29069 NNS denotes concentrations
T27768 29070-29072 IN denotes of
T27769 29073-29078 NN denotes serum
T27770 29079-29083 NN denotes IL-6
T27771 29083-29084 . denotes .
T27772 29085-29092 RB denotes However
T27773 29092-29093 , denotes ,
T27774 29094-29096 PRP denotes it
T27775 29097-29099 VBZ denotes is
T27776 29100-29104 RB denotes also
T27777 29105-29113 JJ denotes possible
T27778 29114-29118 IN denotes that
T27779 29119-29124 JJ denotes STAT3
T27780 29125-29133 NN denotes activity
T27781 29134-29139 MD denotes could
T27782 29140-29142 VB denotes be
T27783 29143-29157 RB denotes constitutively
T27784 29158-29165 VBN denotes induced
T27785 29166-29168 IN denotes in
T27786 29169-29172 CD denotes CD4
T27787 29172-29173 CD denotes +
T27788 29174-29175 NNP denotes T
T27789 29176-29181 NNS denotes cells
T27790 29182-29184 IN denotes by
T27791 29185-29190 PRP$ denotes their
T27792 29191-29194 JJ denotes own
T27793 29195-29200 NN denotes IL-10
T27794 29201-29210 NN denotes secretion
T27795 29210-29211 , denotes ,
T27796 29212-29219 VBG denotes leading
T27797 29220-29222 TO denotes to
T27798 29223-29226 DT denotes the
T27799 29227-29231 NN denotes loss
T27800 29232-29234 IN denotes of
T27801 29235-29246 NN denotes sensitivity
T27802 29247-29249 TO denotes to
T27803 29250-29259 JJ denotes exogenous
T27804 29260-29265 NN denotes IL-10
T27805 29265-29266 , denotes ,
T27806 29267-29274 IN denotes because
T27807 29275-29277 NNP denotes RA
T27808 29278-29281 NNP denotes CD4
T27809 29281-29282 VBD denotes +
T27810 29283-29284 NNP denotes T
T27811 29285-29290 NNS denotes cells
T27812 29291-29293 IN denotes in
T27813 29294-29297 DT denotes the
T27814 29298-29300 NNP denotes ST
T27815 29301-29304 VBP denotes are
T27816 29305-29312 JJ denotes capable
T27817 29313-29315 IN denotes of
T27818 29316-29325 VBG denotes producing
T27819 29326-29337 JJ denotes significant
T27820 29338-29344 NNS denotes levels
T27821 29345-29347 IN denotes of
T27822 29348-29353 NNP denotes IL-10
T27823 29354-29355 NNP denotes [
T27824 29355-29357 CD denotes 34
T27825 29357-29358 NNP denotes ]
T27826 29358-29359 . denotes .
T27827 29360-29363 CD denotes CD4
T27828 29363-29364 CD denotes +
T27829 29365-29366 NNP denotes T
T27830 29367-29372 NNS denotes cells
T27831 29373-29381 VBD denotes isolated
T27832 29382-29386 IN denotes from
T27833 29387-29390 DT denotes the
T27834 29391-29393 NNP denotes ST
T27835 29394-29396 IN denotes of
T27836 29397-29399 NNP denotes RA
T27837 29400-29404 RB denotes also
T27838 29405-29411 VBD denotes showed
T27839 29412-29413 DT denotes a
T27840 29414-29420 NN denotes defect
T27841 29421-29423 IN denotes in
T27842 29424-29427 DT denotes the
T27843 29428-29441 JJ denotes IL-10-induced
T27844 29442-29447 CD denotes STAT3
T27845 29448-29457 VBG denotes signaling
T27846 29458-29465 NN denotes pathway
T27847 29465-29466 . denotes .
T27848 29467-29469 PRP denotes It
T27849 29470-29472 VBZ denotes is
T27850 29473-29477 RBS denotes most
T27851 29478-29486 JJ denotes probable
T27852 29487-29491 IN denotes that
T27853 29492-29495 DT denotes the
T27854 29496-29506 NN denotes resistance
T27855 29507-29509 IN denotes of
T27856 29510-29513 CD denotes CD4
T27857 29513-29514 CD denotes +
T27858 29515-29516 NNP denotes T
T27859 29517-29522 NNS denotes cells
T27860 29523-29525 TO denotes to
T27861 29526-29531 NNP denotes IL-10
T27862 29532-29535 MD denotes can
T27863 29536-29538 VB denotes be
T27864 29539-29543 RB denotes even
T27865 29544-29553 VBN denotes augmented
T27866 29554-29559 IN denotes after
T27867 29560-29569 NN denotes migration
T27868 29570-29574 IN denotes into
T27869 29575-29578 DT denotes the
T27870 29579-29587 JJ denotes inflamed
T27871 29588-29590 NNP denotes ST
T27872 29590-29591 , denotes ,
T27873 29592-29599 IN denotes because
T27874 29600-29604 NNP denotes IL-6
T27875 29605-29607 VBZ denotes is
T27876 29608-29614 RB denotes highly
T27877 29615-29627 VBN denotes concentrated
T27878 29628-29636 VBN denotes compared
T27879 29637-29641 IN denotes with
T27880 29642-29645 DT denotes the
T27881 29646-29651 NN denotes blood
T27882 29652-29657 NN denotes level
T27883 29658-29659 NNP denotes [
T27884 29659-29661 CD denotes 27
T27885 29661-29662 NNP denotes ]
T27886 29662-29663 . denotes .
T27887 29664-29666 IN denotes In
T27888 29667-29675 NN denotes addition
T27889 29675-29676 , denotes ,
T27890 29677-29680 DT denotes the
T27891 29681-29692 NN denotes involvement
T27892 29693-29695 IN denotes of
T27893 29696-29701 JJ denotes other
T27894 29702-29711 JJ denotes essential
T27895 29712-29727 JJ denotes proinflammatory
T27896 29728-29737 NNS denotes cytokines
T27897 29738-29740 IN denotes in
T27898 29741-29745 DT denotes this
T27899 29746-29753 NN denotes process
T27900 29754-29757 VBD denotes was
T27901 29758-29767 VBN denotes suggested
T27902 29768-29770 IN denotes by
T27903 29771-29774 PRP$ denotes our
T27904 29775-29786 JJ denotes preliminary
T27905 29787-29798 NNS denotes experiments
T27906 29799-29812 VBG denotes demonstrating
T27907 29813-29817 IN denotes that
T27908 29818-29832 JJ denotes IL-10-mediated
T27909 29833-29838 JJ denotes IFN-γ
T27910 29839-29849 NN denotes inhibition
T27911 29850-29852 IN denotes in
T27912 29853-29856 NNP denotes CD4
T27913 29856-29857 NNP denotes +
T27914 29858-29859 NNP denotes T
T27915 29860-29865 NNS denotes cells
T27916 29866-29869 VBD denotes was
T27917 29870-29877 VBN denotes reduced
T27918 29878-29880 IN denotes by
T27919 29881-29893 NN denotes pretreatment
T27920 29894-29898 IN denotes with
T27921 29899-29904 JJ denotes IL-1β
T27922 29905-29908 CC denotes and
T27923 29909-29914 JJ denotes TNF-α
T27924 29914-29915 , denotes ,
T27925 29916-29924 IN denotes although
T27926 29925-29929 JJR denotes less
T27927 29930-29941 RB denotes effectively
T27928 29942-29946 IN denotes than
T27929 29947-29949 IN denotes by
T27930 29950-29954 NNP denotes IL-6
T27931 29955-29956 -LRB- denotes (
T27932 29956-29960 NNS denotes data
T27933 29961-29964 RB denotes not
T27934 29965-29970 VBN denotes shown
T27935 29970-29971 -RRB- denotes )
T27936 29971-29972 . denotes .
T27937 29973-29984 RB denotes Furthermore
T27938 29984-29985 , denotes ,
T27939 29986-29991 NNP denotes IFN-γ
T27940 29992-29995 CC denotes and
T27941 29996-30001 NNP denotes IL-10
T27942 30002-30010 VBN denotes produced
T27943 30011-30013 IN denotes by
T27944 30014-30017 NNP denotes CD4
T27945 30017-30018 NNP denotes +
T27946 30019-30020 NNP denotes T
T27947 30021-30026 NNS denotes cells
T27948 30027-30037 PRP denotes themselves
T27949 30038-30043 MD denotes could
T27950 30044-30046 VB denotes be
T27951 30047-30058 JJ denotes responsible
T27952 30059-30062 IN denotes for
T27953 30063-30071 VBN denotes impaired
T27954 30072-30077 NNP denotes IL-10
T27955 30078-30087 VBG denotes signaling
T27956 30088-30090 IN denotes in
T27957 30091-30094 DT denotes the
T27958 30095-30097 NNP denotes ST
T27959 30097-30098 , denotes ,
T27960 30099-30106 IN denotes because
T27961 30107-30113 NNP denotes T-cell
T27962 30114-30125 VBZ denotes infiltrates
T27963 30126-30133 VB denotes produce
T27964 30134-30138 DT denotes both
T27965 30139-30148 NNS denotes cytokines
T27966 30149-30150 NNP denotes [
T27967 30150-30155 CD denotes 34,35
T27968 30155-30156 NNP denotes ]
T27969 30156-30157 . denotes .
T27970 30158-30160 IN denotes In
T27971 30161-30163 DT denotes an
T27972 30164-30173 NN denotes autocrine
T27973 30174-30181 NN denotes fashion
T27974 30181-30182 , denotes ,
T27975 30183-30188 NN denotes IL-10
T27976 30189-30192 MD denotes may
T27977 30193-30205 RB denotes persistently
T27978 30206-30215 VB denotes stimulate
T27979 30216-30221 JJ denotes STAT3
T27980 30222-30232 NN denotes activation
T27981 30233-30236 CC denotes and
T27982 30237-30242 NN denotes IFN-γ
T27983 30243-30246 MD denotes can
T27984 30247-30253 VB denotes induce
T27985 30254-30259 CD denotes SOCS1
T27986 30260-30267 NN denotes protein
T27987 30268-30270 IN denotes as
T27988 30271-30272 DT denotes a
T27989 30273-30282 NN denotes crosstalk
T27990 30283-30292 NN denotes inhibitor
T27991 30293-30295 IN denotes of
T27992 30296-30301 NNP denotes IL-10
T27993 30302-30311 VBG denotes signaling
T27994 30312-30313 NNP denotes [
T27995 30313-30315 CD denotes 32
T27996 30315-30316 NNP denotes ]
T27997 30316-30317 . denotes .
T27998 30318-30321 DT denotes The
T27999 30322-30339 JJ denotes T-cell-inhibitory
T28000 30340-30346 NN denotes effect
T28001 30347-30349 IN denotes of
T28002 30350-30355 NN denotes IL-10
T28003 30356-30359 MD denotes may
T28004 30360-30369 RB denotes therefore
T28005 30370-30372 VB denotes be
T28006 30373-30382 VBN denotes modulated
T28007 30383-30396 RB denotes complicatedly
T28008 30397-30401 IN denotes upon
T28009 30402-30410 NN denotes exposure
T28010 30411-30413 TO denotes to
T28011 30414-30416 DT denotes an
T28012 30417-30429 JJ denotes inflammatory
T28013 30430-30441 NN denotes environment
T28014 30442-30444 IN denotes in
T28015 30445-30447 NNP denotes RA
T28016 30448-30454 NNS denotes joints
T28017 30454-30455 , denotes ,
T28018 30456-30461 WRB denotes where
T28019 30462-30466 JJ denotes many
T28020 30467-30476 NNS denotes cytokines
T28021 30477-30480 VBP denotes are
T28022 30481-30488 JJ denotes present
T28023 30489-30502 RB denotes substantially
T28024 30503-30504 NNP denotes [
T28025 30504-30506 CD denotes 10
T28026 30506-30507 NNP denotes ]
T28027 30507-30508 . denotes .
T28028 30509-30514 CD denotes STAT3
T28029 30515-30525 NN denotes activation
T28030 30526-30529 VBZ denotes has
T28031 30530-30534 VBN denotes been
T28032 30535-30545 VBN denotes implicated
T28033 30546-30548 IN denotes in
T28034 30549-30552 DT denotes the
T28035 30553-30565 NN denotes pathogenesis
T28036 30566-30568 IN denotes of
T28037 30569-30571 NNP denotes RA
T28038 30571-30572 . denotes .
T28039 30573-30579 JJ denotes Active
T28040 30580-30585 NNP denotes STAT3
T28041 30586-30588 VBZ denotes is
T28042 30589-30603 RB denotes constitutively
T28043 30604-30613 VBN denotes expressed
T28044 30614-30616 IN denotes in
T28045 30617-30625 JJ denotes synovial
T28046 30626-30631 NN denotes fluid
T28047 30632-30643 NN denotes mononuclear
T28048 30644-30649 NNS denotes cells
T28049 30650-30654 IN denotes from
T28050 30655-30657 NNP denotes RA
T28051 30658-30666 NNS denotes patients
T28052 30667-30668 NNP denotes [
T28053 30668-30670 CD denotes 36
T28054 30670-30671 NNP denotes ]
T28055 30671-30672 . denotes .
T28056 30673-30677 NN denotes IL-6
T28057 30678-30680 VBZ denotes is
T28058 30681-30684 DT denotes the
T28059 30685-30690 JJ denotes major
T28060 30691-30707 JJ denotes STAT3-activating
T28061 30708-30714 NN denotes factor
T28062 30715-30722 NN denotes present
T28063 30723-30725 IN denotes in
T28064 30726-30734 JJ denotes synovial
T28065 30735-30740 NN denotes fluid
T28066 30740-30741 , denotes ,
T28067 30742-30747 WDT denotes which
T28068 30748-30751 VBZ denotes has
T28069 30752-30753 DT denotes a
T28070 30754-30761 JJ denotes crucial
T28071 30762-30766 NN denotes role
T28072 30767-30769 IN denotes in
T28073 30770-30773 DT denotes the
T28074 30774-30784 NN denotes activation
T28075 30785-30787 IN denotes of
T28076 30788-30796 NN denotes monocyte
T28077 30797-30806 NNS denotes functions
T28078 30807-30811 JJ denotes such
T28079 30812-30814 IN denotes as
T28080 30815-30819 NN denotes gene
T28081 30820-30830 NN denotes expression
T28082 30831-30833 IN denotes of
T28083 30834-30837 DT denotes the
T28084 30838-30840 NNP denotes Fc
T28085 30841-30846 NN denotes gamma
T28086 30847-30855 NN denotes receptor
T28087 30856-30860 NN denotes type
T28088 30861-30862 PRP denotes I
T28089 30863-30866 CC denotes and
T28090 30867-30871 NN denotes type
T28091 30872-30875 NNP denotes III
T28092 30876-30879 CC denotes and
T28093 30880-30882 IN denotes of
T28094 30883-30889 NNP denotes HLA-DR
T28095 30890-30891 NNP denotes [
T28096 30891-30893 CD denotes 31
T28097 30893-30894 NNP denotes ]
T28098 30894-30895 . denotes .
T28099 30896-30900 RBR denotes More
T28100 30901-30909 RB denotes recently
T28101 30909-30910 , denotes ,
T28102 30911-30915 JJ denotes high
T28103 30916-30922 NNS denotes levels
T28104 30923-30925 IN denotes of
T28105 30926-30935 VBN denotes activated
T28106 30936-30941 NNP denotes STAT3
T28107 30941-30942 , denotes ,
T28108 30943-30950 VBD denotes thought
T28109 30951-30953 TO denotes to
T28110 30954-30956 VB denotes be
T28111 30957-30964 JJ denotes induced
T28112 30965-30971 RB denotes mainly
T28113 30972-30974 IN denotes by
T28114 30975-30979 NNP denotes IL-6
T28115 30979-30980 , denotes ,
T28116 30981-30985 VBP denotes have
T28117 30986-30990 VBN denotes been
T28118 30991-30999 VBN denotes detected
T28119 31000-31002 IN denotes in
T28120 31003-31006 DT denotes the
T28121 31007-31009 NNP denotes ST
T28122 31009-31010 , denotes ,
T28123 31011-31014 CC denotes and
T28124 31015-31020 NNP denotes STAT3
T28125 31021-31031 NN denotes activation
T28126 31032-31035 VBZ denotes has
T28127 31036-31040 VBN denotes been
T28128 31041-31046 VBN denotes shown
T28129 31047-31049 TO denotes to
T28130 31050-31052 VB denotes be
T28131 31053-31061 VBN denotes involved
T28132 31062-31064 IN denotes in
T28133 31065-31073 JJ denotes synovial
T28134 31074-31084 NN denotes fibroblast
T28135 31085-31098 NN denotes proliferation
T28136 31099-31102 CC denotes and
T28137 31103-31107 NN denotes IL-6
T28138 31108-31118 NN denotes production
T28139 31119-31120 NNP denotes [
T28140 31120-31122 CD denotes 37
T28141 31122-31123 NNP denotes ]
T28142 31123-31124 . denotes .
T28143 31125-31127 IN denotes In
T28144 31128-31132 DT denotes this
T28145 31133-31139 NN denotes regard
T28146 31139-31140 , denotes ,
T28147 31141-31146 NNP denotes STAT3
T28148 31147-31149 VBZ denotes is
T28149 31150-31158 JJ denotes critical
T28150 31159-31161 IN denotes in
T28151 31162-31165 DT denotes the
T28152 31166-31174 NN denotes survival
T28153 31175-31178 CC denotes and
T28154 31179-31188 NN denotes expansion
T28155 31189-31191 IN denotes of
T28156 31192-31198 NN denotes growth
T28157 31199-31215 JJ denotes factor-dependent
T28158 31216-31224 JJ denotes synovial
T28159 31225-31236 NNS denotes fibroblasts
T28160 31237-31238 NNP denotes [
T28161 31238-31240 CD denotes 38
T28162 31240-31241 NNP denotes ]
T28163 31241-31242 . denotes .
T28164 31243-31254 RB denotes Furthermore
T28165 31254-31255 , denotes ,
T28166 31256-31259 DT denotes the
T28167 31260-31272 NN denotes significance
T28168 31273-31275 IN denotes of
T28169 31276-31286 JJ denotes persistent
T28170 31287-31292 CD denotes STAT3
T28171 31293-31302 VBG denotes signaling
T28172 31303-31305 IN denotes in
T28173 31306-31324 JJ denotes Th1-cell-dominated
T28174 31325-31335 JJ denotes autoimmune
T28175 31336-31345 NN denotes arthritis
T28176 31346-31349 VBZ denotes has
T28177 31350-31354 VBN denotes been
T28178 31355-31364 VBN denotes suggested
T28179 31365-31367 IN denotes by
T28180 31368-31375 NNS denotes studies
T28181 31376-31378 IN denotes of
T28182 31379-31382 DT denotes the
T28183 31383-31397 NNP denotes gp130F759/F759
T28184 31398-31402 NNS denotes mice
T28185 31402-31403 , denotes ,
T28186 31404-31406 IN denotes in
T28187 31407-31412 WDT denotes which
T28188 31413-31416 DT denotes the
T28189 31417-31420 NNP denotes Src
T28190 31421-31429 NN denotes homology
T28191 31430-31443 JJ denotes phosphatase-2
T28192 31444-31451 JJ denotes binding
T28193 31452-31456 NN denotes site
T28194 31457-31459 IN denotes of
T28195 31460-31465 CD denotes gp130
T28196 31466-31467 -LRB- denotes (
T28197 31467-31470 DT denotes the
T28198 31471-31484 NN denotes transmembrane
T28199 31485-31497 NN denotes glycoprotein
T28200 31498-31499 NN denotes β
T28201 31500-31507 NN denotes subunit
T28202 31508-31510 IN denotes of
T28203 31511-31514 DT denotes the
T28204 31515-31519 NNP denotes IL-6
T28205 31520-31526 NN denotes family
T28206 31527-31535 NN denotes cytokine
T28207 31536-31544 NN denotes receptor
T28208 31544-31545 -RRB- denotes )
T28209 31545-31546 , denotes ,
T28210 31547-31555 JJ denotes tyrosine
T28211 31556-31559 CD denotes 759
T28212 31559-31560 , denotes ,
T28213 31561-31564 VBD denotes was
T28214 31565-31572 VBN denotes mutated
T28215 31573-31575 TO denotes to
T28216 31576-31589 VB denotes phenylalanine
T28217 31590-31591 NNP denotes [
T28218 31591-31593 CD denotes 39
T28219 31593-31594 NNP denotes ]
T28220 31594-31595 . denotes .
T28221 31596-31598 IN denotes In
T28222 31599-31602 DT denotes the
T28223 31603-31617 NNP denotes gp130F759/F759
T28224 31618-31622 NNS denotes mice
T28225 31622-31623 , denotes ,
T28226 31624-31625 NNP denotes T
T28227 31626-31631 NNS denotes cells
T28228 31631-31632 , denotes ,
T28229 31633-31645 RB denotes particularly
T28230 31646-31649 DT denotes the
T28231 31650-31653 NNP denotes CD4
T28232 31653-31654 NNP denotes +
T28233 31655-31661 NNP denotes T-cell
T28234 31662-31668 NN denotes subset
T28235 31668-31669 , denotes ,
T28236 31670-31673 VBP denotes are
T28237 31674-31685 RB denotes chronically
T28238 31686-31695 VBN denotes activated
T28239 31696-31699 CC denotes and
T28240 31700-31709 JJ denotes resistant
T28241 31710-31712 TO denotes to
T28242 31713-31731 JJ denotes activation-induced
T28243 31732-31736 NN denotes cell
T28244 31737-31742 NN denotes death
T28245 31743-31750 IN denotes through
T28246 31751-31765 JJ denotes gp130-mediated
T28247 31766-31771 CD denotes STAT3
T28248 31772-31782 NN denotes activation
T28249 31782-31783 . denotes .
T28250 31784-31787 DT denotes The
T28251 31788-31797 NN denotes longevity
T28252 31798-31800 IN denotes of
T28253 31801-31809 NN denotes cytokine
T28254 31810-31817 NNS denotes signals
T28255 31818-31828 VBN denotes transduced
T28256 31829-31831 IN denotes by
T28257 31832-31835 DT denotes the
T28258 31836-31839 NNP denotes JAK
T28259 31840-31844 NNP denotes STAT
T28260 31845-31852 NN denotes pathway
T28261 31853-31855 VBZ denotes is
T28262 31856-31865 VBN denotes regulated
T28263 31866-31868 IN denotes by
T28264 31869-31872 DT denotes the
T28265 31873-31877 NNP denotes SOCS
T28266 31878-31884 NN denotes family
T28267 31885-31893 NNS denotes proteins
T28268 31894-31895 VBP denotes [
T28269 31895-31896 CD denotes 7
T28270 31896-31897 NNP denotes ]
T28271 31897-31898 . denotes .
T28272 31899-31901 PRP denotes We
T28273 31902-31907 VBD denotes found
T28274 31908-31912 IN denotes that
T28275 31913-31916 CD denotes CD4
T28276 31916-31917 CD denotes +
T28277 31918-31919 NNP denotes T
T28278 31920-31925 NNS denotes cells
T28279 31926-31930 IN denotes from
T28280 31931-31939 NNS denotes patients
T28281 31940-31944 IN denotes with
T28282 31945-31951 JJ denotes active
T28283 31952-31954 NNP denotes RA
T28284 31955-31964 VBD denotes expressed
T28285 31965-31971 JJR denotes higher
T28286 31972-31978 NNS denotes levels
T28287 31979-31981 IN denotes of
T28288 31982-31987 NNP denotes SOCS1
T28289 31987-31988 , denotes ,
T28290 31989-31992 CC denotes but
T28291 31993-31998 JJR denotes lower
T28292 31999-32005 NNS denotes levels
T28293 32006-32008 IN denotes of
T28294 32009-32014 NNP denotes SOCS3
T28295 32014-32015 , denotes ,
T28296 32016-32024 VBN denotes compared
T28297 32025-32029 IN denotes with
T28298 32030-32036 JJ denotes normal
T28299 32037-32040 NNP denotes CD4
T28300 32040-32041 CD denotes +
T28301 32042-32043 NNP denotes T
T28302 32044-32049 NNS denotes cells
T28303 32049-32050 . denotes .
T28304 32051-32056 CD denotes SOCS1
T28305 32057-32065 VBZ denotes prevents
T28306 32066-32076 NN denotes activation
T28307 32077-32079 IN denotes of
T28308 32080-32083 NNP denotes JAK
T28309 32084-32086 IN denotes by
T28310 32087-32095 RB denotes directly
T28311 32096-32103 JJ denotes binding
T28312 32104-32106 TO denotes to
T28313 32107-32110 NNP denotes JAK
T28314 32110-32111 , denotes ,
T28315 32112-32115 CC denotes and
T28316 32116-32121 NNP denotes SOCS3
T28317 32122-32130 VBZ denotes inhibits
T28318 32131-32134 DT denotes the
T28319 32135-32141 NN denotes action
T28320 32142-32144 IN denotes of
T28321 32145-32148 NNP denotes JAK
T28322 32149-32151 IN denotes by
T28323 32152-32159 JJ denotes binding
T28324 32160-32162 TO denotes to
T28325 32163-32166 DT denotes the
T28326 32167-32170 NNP denotes Src
T28327 32171-32179 NN denotes homology
T28328 32180-32201 JJ denotes phosphatase-2-binding
T28329 32202-32208 NN denotes domain
T28330 32209-32211 IN denotes of
T28331 32212-32221 NNS denotes receptors
T28332 32222-32226 JJ denotes such
T28333 32227-32229 IN denotes as
T28334 32230-32235 CD denotes gp130
T28335 32236-32237 NNP denotes [
T28336 32237-32239 CD denotes 40
T28337 32239-32240 NNP denotes ]
T28338 32240-32241 . denotes .
T28339 32242-32247 CD denotes SOCS1
T28340 32248-32251 CC denotes and
T28341 32252-32257 CD denotes SOCS3
T28342 32258-32261 VBP denotes are
T28343 32262-32269 VBN denotes induced
T28344 32270-32272 IN denotes by
T28345 32273-32280 JJ denotes various
T28346 32281-32290 NNS denotes cytokines
T28347 32290-32291 , denotes ,
T28348 32292-32301 VBG denotes including
T28349 32302-32306 NNP denotes IL-6
T28350 32307-32310 CC denotes and
T28351 32311-32316 NNP denotes IL-10
T28352 32316-32317 , denotes ,
T28353 32318-32320 IN denotes as
T28354 32321-32330 NNS denotes mediators
T28355 32331-32333 IN denotes of
T28356 32334-32342 JJ denotes negative
T28357 32343-32351 NN denotes feedback
T28358 32352-32355 CC denotes and
T28359 32356-32365 NN denotes crosstalk
T28360 32366-32376 NN denotes inhibition
T28361 32377-32378 NN denotes [
T28362 32378-32379 CD denotes 7
T28363 32379-32380 NNP denotes ]
T28364 32380-32381 . denotes .
T28365 32382-32388 JJ denotes Recent
T28366 32389-32396 NNS denotes studies
T28367 32397-32401 IN denotes with
T28368 32402-32406 NNS denotes mice
T28369 32407-32414 VBG denotes lacking
T28370 32415-32420 CD denotes SOCS3
T28371 32421-32423 CC denotes or
T28372 32424-32429 CD denotes SOCS1
T28373 32430-32438 VBD denotes revealed
T28374 32439-32443 IN denotes that
T28375 32444-32449 CD denotes SOCS3
T28376 32450-32452 VBZ denotes is
T28377 32453-32454 DT denotes a
T28378 32455-32463 JJ denotes negative
T28379 32464-32473 NN denotes regulator
T28380 32474-32476 IN denotes of
T28381 32477-32481 NNP denotes IL-6
T28382 32482-32491 VBG denotes signaling
T28383 32492-32495 CC denotes but
T28384 32496-32499 RB denotes not
T28385 32500-32502 IN denotes of
T28386 32503-32508 NN denotes IL-10
T28387 32509-32518 VBG denotes signaling
T28388 32518-32519 . denotes .
T28389 32520-32527 NNS denotes Studies
T28390 32528-32530 IN denotes of
T28391 32531-32542 JJ denotes conditional
T28392 32543-32558 JJ denotes SOCS3-deficient
T28393 32559-32563 NNS denotes mice
T28394 32564-32568 VBP denotes have
T28395 32569-32574 VBN denotes shown
T28396 32575-32579 IN denotes that
T28397 32580-32585 CD denotes SOCS3
T28398 32586-32596 NN denotes deficiency
T28399 32596-32597 , denotes ,
T28400 32598-32601 CC denotes but
T28401 32602-32605 RB denotes not
T28402 32606-32611 CD denotes SOCS1
T28403 32612-32622 NN denotes deficiency
T28404 32622-32623 , denotes ,
T28405 32624-32631 NNS denotes results
T28406 32632-32634 IN denotes in
T28407 32635-32644 VBN denotes sustained
T28408 32645-32655 NN denotes activation
T28409 32656-32658 IN denotes of
T28410 32659-32664 CD denotes STAT3
T28411 32665-32667 IN denotes in
T28412 32668-32676 NN denotes response
T28413 32677-32679 TO denotes to
T28414 32680-32684 NNP denotes IL-6
T28415 32685-32686 NNP denotes [
T28416 32686-32690 CD denotes 8,41
T28417 32690-32691 NNP denotes ]
T28418 32691-32692 . denotes .
T28419 32693-32696 DT denotes The
T28420 32697-32705 NN denotes analysis
T28421 32706-32708 IN denotes of
T28422 32709-32724 JJ denotes SOCS3-deficient
T28423 32725-32736 NNS denotes macrophages
T28424 32737-32740 VBZ denotes has
T28425 32741-32750 VBN denotes indicated
T28426 32751-32755 IN denotes that
T28427 32756-32761 CD denotes SOCS3
T28428 32762-32764 VBZ denotes is
T28429 32765-32766 DT denotes a
T28430 32767-32774 JJ denotes crucial
T28431 32775-32784 NN denotes inhibitor
T28432 32785-32787 IN denotes of
T28433 32788-32791 DT denotes the
T28434 32792-32804 JJ denotes IL-6-induced
T28435 32805-32820 JJ denotes transcriptional
T28436 32821-32829 NN denotes response
T28437 32830-32831 NNP denotes [
T28438 32831-32833 CD denotes 42
T28439 32833-32834 NNP denotes ]
T28440 32834-32835 . denotes .
T28441 32836-32843 RB denotes However
T28442 32843-32844 , denotes ,
T28443 32845-32850 NNP denotes SOCS3
T28444 32851-32853 VBZ denotes is
T28445 32854-32865 JJ denotes dispensable
T28446 32866-32869 IN denotes for
T28447 32870-32874 DT denotes both
T28448 32875-32878 DT denotes the
T28449 32879-32887 JJ denotes negative
T28450 32888-32896 NN denotes feedback
T28451 32897-32907 NN denotes inhibition
T28452 32908-32911 CC denotes and
T28453 32912-32915 DT denotes the
T28454 32916-32932 JJ denotes immunoregulatory
T28455 32933-32939 NN denotes action
T28456 32940-32942 IN denotes of
T28457 32943-32948 NN denotes IL-10
T28458 32949-32951 IN denotes in
T28459 32952-32963 NNS denotes macrophages
T28460 32964-32965 NNP denotes [
T28461 32965-32967 CD denotes 41
T28462 32967-32968 NNP denotes ]
T28463 32968-32969 . denotes .
T28464 32970-32972 IN denotes On
T28465 32973-32976 DT denotes the
T28466 32977-32985 NN denotes contrary
T28467 32985-32986 , denotes ,
T28468 32987-32992 NNP denotes SOCS1
T28469 32993-32996 VBD denotes was
T28470 32997-33002 VBN denotes found
T28471 33003-33005 TO denotes to
T28472 33006-33014 RB denotes directly
T28473 33015-33022 VB denotes inhibit
T28474 33023-33037 JJ denotes IL-10-mediated
T28475 33038-33047 VBG denotes signaling
T28476 33048-33049 NNP denotes [
T28477 33049-33051 CD denotes 43
T28478 33051-33052 NNP denotes ]
T28479 33052-33053 . denotes .
T28480 33054-33063 VBN denotes Increased
T28481 33064-33069 CD denotes SOCS1
T28482 33070-33080 NN denotes expression
T28483 33081-33083 IN denotes in
T28484 33084-33086 NNP denotes RA
T28485 33087-33090 NNP denotes CD4
T28486 33090-33091 VBD denotes +
T28487 33092-33093 NNP denotes T
T28488 33094-33099 NNS denotes cells
T28489 33100-33103 MD denotes may
T28490 33104-33113 RB denotes therefore
T28491 33114-33116 VB denotes be
T28492 33117-33127 VBN denotes associated
T28493 33128-33132 IN denotes with
T28494 33133-33137 DT denotes both
T28495 33138-33141 DT denotes the
T28496 33142-33150 VBN denotes impaired
T28497 33151-33165 NN denotes responsiveness
T28498 33166-33168 TO denotes to
T28499 33169-33174 NNP denotes IL-10
T28500 33175-33178 CC denotes and
T28501 33179-33181 TO denotes to
T28502 33182-33196 JJ denotes IL-10-mediated
T28503 33197-33202 CD denotes STAT3
T28504 33203-33213 NN denotes activation
T28505 33213-33214 , denotes ,
T28506 33215-33218 CC denotes and
T28507 33219-33228 JJ denotes defective
T28508 33229-33234 CD denotes SOCS3
T28509 33235-33245 NN denotes expression
T28510 33246-33249 MD denotes may
T28511 33250-33252 VB denotes be
T28512 33253-33264 JJ denotes responsible
T28513 33265-33268 IN denotes for
T28514 33269-33279 JJ denotes persistent
T28515 33280-33285 CD denotes STAT3
T28516 33286-33296 NN denotes activation
T28517 33297-33299 IN denotes in
T28518 33300-33308 NN denotes response
T28519 33309-33311 TO denotes to
T28520 33312-33317 VB denotes serum
T28521 33318-33322 NNP denotes IL-6
T28522 33322-33323 . denotes .
T28523 33324-33329 EX denotes There
T28524 33330-33332 VBZ denotes is
T28525 33333-33334 DT denotes a
T28526 33335-33346 NN denotes possibility
T28527 33347-33351 IN denotes that
T28528 33352-33357 CD denotes SOCS1
T28529 33358-33367 NN denotes induction
T28530 33368-33371 MD denotes may
T28531 33372-33374 VB denotes be
T28532 33375-33385 VBN denotes associated
T28533 33386-33390 IN denotes with
T28534 33391-33394 DT denotes the
T28535 33395-33402 NN denotes ability
T28536 33403-33405 IN denotes of
T28537 33406-33409 CD denotes CD4
T28538 33409-33410 CD denotes +
T28539 33411-33412 NNP denotes T
T28540 33413-33418 NNS denotes cells
T28541 33419-33421 TO denotes to
T28542 33422-33429 VB denotes produce
T28543 33430-33435 NNP denotes IFN-γ
T28544 33435-33436 , denotes ,
T28545 33437-33444 IN denotes because
T28546 33445-33448 NNP denotes CD4
T28547 33448-33449 NNP denotes +
T28548 33450-33451 NNP denotes T
T28549 33452-33457 NNS denotes cells
T28550 33458-33462 IN denotes from
T28551 33463-33469 JJ denotes active
T28552 33470-33472 NNP denotes RA
T28553 33473-33478 MD denotes could
T28554 33479-33486 VB denotes produce
T28655 33487-33491 JJ denotes high
T28656 33492-33498 NNS denotes levels
T28657 33499-33501 IN denotes of
T28658 33502-33507 NNP denotes IFN-γ
T28659 33508-33510 IN denotes in
T28660 33511-33514 DT denotes the
T28661 33515-33523 NN denotes presence
T28662 33524-33526 IN denotes of
T28663 33527-33532 NNP denotes IL-10
T28664 33532-33533 , denotes ,
T28893 33534-33537 CC denotes and
T28894 33538-33545 IN denotes because
T28895 33546-33551 NNP denotes IFN-γ
T28896 33552-33555 VBZ denotes has
T28897 33556-33560 VBN denotes been
T28898 33561-33566 VBN denotes known
T28899 33567-33569 IN denotes as
T28900 33570-33571 DT denotes a
T28901 33572-33578 JJ denotes potent
T28902 33579-33586 NN denotes inducer
T28903 33587-33589 IN denotes of
T28904 33590-33595 CD denotes SOCS1
T28905 33596-33597 NNP denotes [
T28906 33597-33599 CD denotes 32
T28907 33599-33600 NNP denotes ]
T28908 33600-33601 . denotes .
T28909 33602-33604 PRP denotes It
T28910 33605-33607 VBZ denotes is
T28911 33608-33610 IN denotes of
T28912 33611-33619 NN denotes interest
T28913 33620-33622 IN denotes in
T28914 33623-33627 DT denotes this
T29178 33628-33634 NN denotes regard
T29179 33635-33637 TO denotes to
T29180 33638-33646 VB denotes indicate
T29181 33647-33651 DT denotes that
T29182 33652-33661 VBN denotes polarized
T29183 33662-33665 NNP denotes Th1
T29184 33666-33669 CC denotes and
T29185 33670-33673 NNP denotes Th2
T29186 33674-33679 NNS denotes cells
T29187 33680-33687 VBP denotes express
T29188 33688-33692 JJ denotes high
T29189 33693-33699 NNS denotes levels
T29190 33700-33702 IN denotes of
T29191 33703-33708 CD denotes SOCS1
T29192 33709-33712 CC denotes and
T29193 33713-33718 CD denotes SOCS3
T29194 33719-33723 NNP denotes mRNA
T29195 33723-33724 , denotes ,
T29196 33725-33737 RB denotes respectively
T29197 33738-33739 NNP denotes [
T29198 33739-33741 CD denotes 44
T29199 33741-33742 NNP denotes ]
T29200 33742-33743 . denotes .
T29201 33744-33757 JJ denotes IL-12-induced
T29202 33758-33763 CD denotes STAT4
T29203 33764-33774 NN denotes activation
T29204 33775-33777 VBZ denotes is
T29205 33778-33787 VBN denotes inhibited
T29206 33788-33790 IN denotes by
T29207 33791-33796 CD denotes SOCS3
T29208 33797-33806 NN denotes induction
T29209 33807-33809 IN denotes in
T29210 33810-33813 JJ denotes Th2
T29211 33814-33819 NNS denotes cells
T29212 33819-33820 , denotes ,
T29213 33821-33828 IN denotes whereas
T29214 33829-33841 JJ denotes IL-4-induced
T29215 33842-33847 NNP denotes STAT6
T29216 33848-33857 VBG denotes signaling
T29217 33858-33860 VBZ denotes is
T29218 33861-33871 VBN denotes diminished
T29219 33872-33874 IN denotes by
T29220 33875-33880 CD denotes SOCS1
T29221 33881-33890 NN denotes induction
T29222 33891-33893 IN denotes in
T29223 33894-33897 JJ denotes Th1
T29224 33898-33903 NNS denotes cells
T29225 33903-33904 . denotes .
T29226 33905-33910 CD denotes SOCS1
T29227 33911-33914 CC denotes and
T29228 33915-33920 CD denotes SOCS3
T29229 33921-33924 MD denotes may
T29230 33925-33929 RB denotes thus
T29231 33930-33934 VB denotes have
T29232 33935-33944 JJ denotes important
T29233 33945-33950 NNS denotes roles
T29234 33951-33953 IN denotes as
T29235 33954-33966 JJ denotes Th1-specific
T29236 33967-33970 CC denotes and
T29237 33971-33983 JJ denotes Th2-specific
T29238 33983-33984 , denotes ,
T29239 33985-33993 RB denotes mutually
T29240 33994-34003 JJ denotes exclusive
T29241 34003-34004 , denotes ,
T29242 34005-34015 JJ denotes cross-talk
T29243 34016-34026 NNS denotes repressors
T29244 34027-34029 IN denotes of
T29245 34030-34033 DT denotes the
T29246 34034-34038 NN denotes IL-4
T29247 34039-34044 CD denotes STAT6
T29248 34045-34048 CC denotes and
T29249 34049-34052 DT denotes the
T29250 34053-34058 NN denotes IL-12
T29251 34059-34064 CD denotes STAT4
T29252 34065-34074 VBG denotes signaling
T29253 34075-34083 NNS denotes pathways
T29254 34083-34084 , denotes ,
T29255 34085-34097 RB denotes respectively
T29256 34097-34098 . denotes .
T29257 34099-34109 JJ denotes Consistent
T29258 34110-34114 IN denotes with
T29259 34115-34119 DT denotes this
T29260 34120-34126 NN denotes notion
T29261 34126-34127 , denotes ,
T29262 34128-34130 NNP denotes PB
T29263 34131-34132 NNP denotes T
T29264 34133-34138 NNS denotes cells
T29265 34139-34143 IN denotes from
T29266 34144-34152 NNS denotes patients
T29267 34153-34157 IN denotes with
T29268 34158-34166 JJ denotes allergic
T29269 34167-34175 NNS denotes diseases
T29270 34176-34189 RB denotes significantly
T29271 34190-34197 VBP denotes express
T29272 34198-34202 JJ denotes high
T29273 34203-34209 NNS denotes levels
T29274 34210-34212 IN denotes of
T29275 34213-34218 CD denotes SOCS3
T29276 34219-34230 NNS denotes transcripts
T29277 34230-34231 , denotes ,
T29278 34232-34235 CC denotes and
T29279 34236-34239 DT denotes the
T29280 34240-34245 NNP denotes SOCS3
T29281 34246-34256 NN denotes expression
T29282 34257-34267 VBZ denotes correlates
T29283 34268-34272 RB denotes well
T29284 34273-34277 IN denotes with
T29285 34278-34283 NN denotes serum
T29286 34284-34287 NNP denotes IgE
T29287 34288-34294 NNS denotes levels
T29288 34295-34298 CC denotes and
T29289 34299-34306 NN denotes disease
T29290 34307-34316 NN denotes pathology
T29291 34317-34318 NNP denotes [
T29292 34318-34320 CD denotes 45
T29293 34320-34321 NNP denotes ]
T29294 34321-34322 . denotes .
T29295 34323-34329 JJR denotes Higher
T29296 34330-34335 CD denotes SOCS1
T29297 34336-34346 NN denotes expression
T29298 34347-34351 IN denotes with
T29299 34352-34357 JJR denotes lower
T29300 34358-34363 JJ denotes SOCS3
T29301 34364-34374 NN denotes expression
T29302 34375-34377 IN denotes in
T29303 34378-34380 NNP denotes PB
T29304 34381-34384 NNP denotes CD4
T29305 34384-34385 VBD denotes +
T29306 34386-34387 NNP denotes T
T29307 34388-34393 NNS denotes cells
T29308 34394-34398 IN denotes from
T29309 34399-34401 NNP denotes RA
T29310 34402-34410 NNS denotes patients
T29311 34410-34411 , denotes ,
T29312 34412-34420 VBN denotes compared
T29313 34421-34425 IN denotes with
T29314 34426-34433 JJ denotes healthy
T29315 34434-34442 NNS denotes controls
T29316 34442-34443 , denotes ,
T29317 34444-34446 VBZ denotes is
T29318 34447-34456 RB denotes therefore
T29319 34457-34465 RB denotes probably
T29320 34466-34476 JJ denotes consistent
T29321 34477-34481 IN denotes with
T29322 34482-34487 PRP$ denotes their
T29323 34488-34496 JJ denotes systemic
T29324 34497-34501 NN denotes bias
T29325 34502-34509 IN denotes towards
T29326 34510-34511 DT denotes a
T29327 34512-34515 JJ denotes Th1
T29328 34516-34525 NN denotes phenotype
T29329 34525-34526 , denotes ,
T29330 34527-34529 RB denotes as
T29331 34530-34533 VBZ denotes has
T29332 34534-34544 RB denotes previously
T29333 34545-34549 VBN denotes been
T29334 34550-34562 VBN denotes demonstrated
T29335 34563-34564 NNP denotes [
T29336 34564-34569 CD denotes 46-49
T29337 34569-34570 NNP denotes ]
T29338 34570-34571 . denotes .
T31256 34584-34587 CD denotes CD4
T31257 34587-34588 CD denotes +
T31258 34589-34590 NNP denotes T
T31259 34591-34596 NNS denotes cells
T31260 34597-34601 IN denotes from
T31261 34602-34608 JJ denotes active
T31262 34609-34611 NNP denotes RA
T31263 34612-34620 NNS denotes patients
T31264 34621-34624 VBP denotes are
T31265 34625-34638 VBN denotes characterized
T31266 34639-34641 IN denotes by
T31267 34642-34647 PRP$ denotes their
T31268 34648-34658 NN denotes resistance
T31269 34659-34661 TO denotes to
T31270 34662-34667 NNP denotes IL-10
T31271 34668-34678 NN denotes inhibition
T31272 34679-34681 IN denotes of
T31273 34682-34687 JJ denotes IFN-γ
T31274 34688-34698 NN denotes production
T31275 34698-34699 , denotes ,
T31276 34700-34703 JJ denotes due
T31277 34704-34706 TO denotes to
T31278 34707-34719 VB denotes constitutive
T31279 34720-34725 CD denotes STAT3
T31280 34726-34741 NN denotes phosphorylation
T31281 34742-34745 CC denotes and
T31282 34746-34754 VBN denotes impaired
T31283 34755-34769 JJ denotes IL-10-mediated
T31284 34770-34775 CD denotes STAT3
T31285 34776-34786 NN denotes activation
T31286 34786-34787 . denotes .
T31287 34788-34791 DT denotes The
T31288 34792-34801 JJ denotes defective
T31289 34802-34807 CD denotes STAT3
T31290 34808-34817 VBG denotes signaling
T31291 34818-34820 VBZ denotes is
T31292 34821-34829 RB denotes possibly
T31293 34830-34840 VBN denotes associated
T31294 34841-34845 IN denotes with
T31295 34846-34851 CD denotes SOCS1
T31296 34852-34864 NN denotes predominance
T31297 34865-34869 IN denotes over
T31298 34870-34875 CD denotes SOCS3
T31299 34875-34876 . denotes .
T31300 34877-34882 DT denotes These
T31301 34883-34896 NNS denotes abnormalities
T31302 34897-34899 IN denotes in
T31303 34900-34906 JJ denotes active
T31304 34907-34909 NNP denotes RA
T31305 34910-34913 VBP denotes are
T31306 34914-34921 VBN denotes thought
T31307 34922-34924 TO denotes to
T31308 34925-34927 VB denotes be
T31309 34928-34935 JJ denotes induced
T31310 34936-34942 RB denotes mainly
T31311 34943-34948 IN denotes after
T31312 34949-34956 JJ denotes chronic
T31313 34957-34965 NN denotes exposure
T31314 34966-34968 TO denotes to
T31315 34969-34973 JJ denotes high
T31316 34974-34988 NNS denotes concentrations
T31317 34989-34991 IN denotes of
T31318 34992-34996 NN denotes IL-6
T31319 34996-34997 . denotes .
T31320 34998-35001 DT denotes The
T31321 35002-35009 JJ denotes limited
T31322 35010-35018 NN denotes efficacy
T31323 35019-35021 IN denotes of
T31324 35022-35027 JJ denotes IL-10
T31325 35028-35037 NN denotes treatment
T31326 35038-35040 IN denotes of
T31327 35041-35043 NNP denotes RA
T31328 35044-35052 NNS denotes patients
T31329 35053-35054 NNP denotes [
T31330 35054-35056 CD denotes 50
T31331 35056-35057 NNP denotes ]
T31332 35058-35061 MD denotes may
T31333 35062-35064 VB denotes be
T31334 35065-35074 VBN denotes explained
T31335 35075-35077 IN denotes in
T31336 35078-35082 NN denotes part
T31337 35083-35085 IN denotes by
T31338 35086-35089 DT denotes the
T31339 35090-35106 NN denotes unresponsiveness
T31340 35107-35109 TO denotes to
T31341 35110-35115 NNP denotes IL-10
T31342 35116-35118 IN denotes of
T31343 35119-35131 JJ denotes inflammatory
T31344 35132-35137 NNS denotes cells
T31345 35137-35138 , denotes ,
T31346 35139-35148 VBG denotes including
T31347 35149-35150 NNP denotes T
T31348 35151-35156 NNS denotes cells
T31349 35156-35157 . denotes .
T31350 35158-35160 IN denotes On
T31351 35161-35164 DT denotes the
T31352 35165-35173 NN denotes contrary
T31353 35173-35174 , denotes ,
T31354 35175-35178 DT denotes the
T31355 35179-35190 JJ denotes therapeutic
T31356 35191-35199 NN denotes efficacy
T31357 35200-35202 IN denotes of
T31358 35203-35212 NN denotes anti-IL-6
T31359 35213-35221 NN denotes receptor
T31360 35222-35230 NN denotes antibody
T31361 35231-35234 VBZ denotes has
T31362 35235-35239 VBN denotes been
T31363 35240-35248 VBN denotes reported
T31364 35249-35251 IN denotes in
T31365 35252-35254 NNP denotes RA
T31366 35255-35263 NNS denotes patients
T31367 35264-35265 NNP denotes [
T31368 35265-35267 CD denotes 51
T31369 35267-35268 NNP denotes ]
T31370 35268-35269 , denotes ,
T31371 35270-35273 CC denotes and
T31372 35274-35277 CD denotes one
T31373 35278-35280 IN denotes of
T31374 35281-35284 DT denotes the
T31375 35285-35292 NNS denotes effects
T31376 35293-35295 IN denotes of
T31377 35296-35300 DT denotes this
T31378 35301-35308 NN denotes therapy
T31379 35309-35312 MD denotes may
T31380 35313-35315 VB denotes be
T31381 35316-35318 TO denotes to
T31382 35319-35328 VB denotes normalize
T31383 35329-35330 NNP denotes T
T31384 35331-35336 NNS denotes cells
T31385 35337-35344 IN denotes through
T31386 35345-35348 DT denotes the
T31387 35349-35359 NN denotes inhibition
T31388 35360-35362 IN denotes of
T31389 35363-35377 JJ denotes IL-6-dependent
T31390 35378-35383 CD denotes STAT3
T31391 35384-35394 NN denotes activation
T31392 35394-35395 . denotes .
T31393 35396-35400 RBR denotes More
T31394 35401-35409 JJ denotes specific
T31395 35410-35417 NN denotes therapy
T31396 35418-35427 VBG denotes targeting
T31397 35428-35433 CD denotes STAT3
T31398 35434-35444 NN denotes activation
T31399 35445-35449 MD denotes will
T31400 35450-35452 VB denotes be
T31401 35453-35460 VBN denotes awaited
T31402 35460-35461 : denotes ;
T31403 35462-35465 IN denotes for
T31404 35466-35473 NN denotes example
T31405 35473-35474 , denotes ,
T31406 35475-35478 DT denotes the
T31407 35479-35488 NN denotes induction
T31408 35489-35491 IN denotes of
T31409 35492-35495 DT denotes the
T31410 35496-35501 CD denotes SOCS3
T31411 35502-35506 NN denotes gene
T31412 35506-35507 , denotes ,
T31413 35508-35511 DT denotes the
T31414 35512-35520 NN denotes efficacy
T31415 35521-35523 IN denotes of
T31416 35524-35529 WDT denotes which
T31417 35530-35533 VBZ denotes has
T31418 35534-35538 VBN denotes been
T31419 35539-35551 VBN denotes demonstrated
T31420 35552-35554 IN denotes in
T31421 35555-35561 NN denotes animal
T31422 35562-35568 NNS denotes models
T31423 35569-35570 NNP denotes [
T31424 35570-35572 CD denotes 37
T31425 35572-35573 NNP denotes ]
T31426 35573-35574 . denotes .
R10484 T20959 T20960 compound High,expression
R10485 T20960 T20971 nsubj expression,induces
R10486 T20961 T20960 prep of,expression
R10487 T20962 T20963 nummod SOCS1,mRNA
R10488 T20963 T20969 nmod mRNA,cells
R10489 T20964 T20963 prep in,mRNA
R10490 T20965 T20966 compound RA,CD4
R10491 T20966 T20964 pobj CD4,in
R10492 T20967 T20969 amod +,cells
R10493 T20968 T20969 compound T,cells
R10494 T20969 T20961 pobj cells,of
R10495 T20970 T20971 nsubj IL-6,induces
R10496 T20971 T20971 ROOT induces,induces
R10497 T20972 T20974 nummod two,inhibitors
R10498 T20973 T20974 amod potent,inhibitors
R10499 T20974 T20971 dobj inhibitors,induces
R10500 T20975 T20974 prep of,inhibitors
R10501 T20976 T20975 pobj JAKs,of
R10502 T20977 T20976 punct (,JAKs
R10503 T20978 T20981 nummod SOCS1,proteins
R10504 T20979 T20978 cc and,SOCS1
R10505 T20980 T20978 conj SOCS3,SOCS1
R10506 T20981 T20976 appos proteins,JAKs
R10507 T20982 T20976 punct ),JAKs
R10508 T20983 T20986 nsubj that,act
R10509 T20984 T20986 neg not,act
R10510 T20985 T20986 amod only,act
R10511 T20986 T20974 relcl act,inhibitors
R10512 T20987 T20986 prep as,act
R10513 T20988 T20987 pobj mediators,as
R10514 T20989 T20988 prep of,mediators
R10515 T20990 T20992 amod negative,inhibition
R10516 T20991 T20992 compound feedback,inhibition
R10517 T20992 T20989 pobj inhibition,of
R10518 T20993 T20986 punct ",",act
R10519 T20994 T20986 cc but,act
R10520 T20995 T20996 advmod also,play
R10521 T20996 T20986 conj play,act
R10522 T20997 T20999 det a,role
R10523 T20998 T20999 amod major,role
R10524 T20999 T20996 dobj role,play
R10525 T21000 T20996 prep in,play
R10526 T21001 T21002 compound crosstalk,inhibition
R10527 T21002 T21000 pobj inhibition,in
R10528 T21003 T20996 prep by,play
R10529 T21004 T21003 pcomp opposing,by
R10530 T21005 T21007 amod other,pathways
R10531 T21006 T21007 amod cytokine-signaling,pathways
R10532 T21007 T21004 dobj pathways,opposing
R10533 T21008 T20996 conj [,play
R10534 T21009 T21010 nummod 7,]
R10535 T21010 T21008 dobj ],[
R10536 T21011 T20971 punct .,induces
R10537 T21012 T21016 nsubj SOCS3,shown
R10538 T21013 T21016 aux has,shown
R10539 T21014 T21016 advmod recently,shown
R10540 T21015 T21016 auxpass been,shown
R10541 T21016 T21016 ROOT shown,shown
R10542 T21017 T21019 aux to,inhibit
R10543 T21018 T21019 advmod specifically,inhibit
R10544 T21019 T21016 advcl inhibit,shown
R10545 T21020 T21021 amod STAT3,activation
R10546 T21021 T21019 dobj activation,inhibit
R10547 T21022 T21021 acl induced,activation
R10548 T21023 T21022 agent by,induced
R10549 T21024 T21023 pobj IL-6,by
R10550 T21025 T21022 cc but,induced
R10551 T21026 T21027 neg not,by
R10552 T21027 T21022 conj by,induced
R10553 T21028 T21027 pobj IL-10,by
R10554 T21029 T21016 punct ",",shown
R10555 T21030 T21031 advmod thereby,regulating
R10556 T21031 T21016 advcl regulating,shown
R10557 T21032 T21034 det the,action
R10558 T21033 T21034 amod divergent,action
R10559 T21034 T21031 dobj action,regulating
R10560 T21035 T21034 prep of,action
R10561 T21036 T21035 pobj IL-6,of
R10562 T21037 T21036 cc and,IL-6
R10563 T21038 T21039 compound IL-10,[
R10564 T21039 T21034 appos [,action
R10565 T21040 T21041 nummod "8,9",]
R10566 T21041 T21039 appos ],[
R10567 T21042 T21016 punct .,shown
R10568 T21043 T21048 prep On,is
R10569 T21044 T21045 det the,contrary
R10570 T21045 T21043 pobj contrary,On
R10571 T21046 T21048 punct ",",is
R10572 T21047 T21048 nsubj SOCS1,is
R10573 T21048 T21048 ROOT is,is
R10574 T21049 T21048 acomp able,is
R10575 T21050 T21052 aux to,inhibit
R10576 T21051 T21052 advmod partially,inhibit
R10577 T21052 T21049 xcomp inhibit,able
R10578 T21053 T21055 amod IL-10-mediated,activation
R10579 T21054 T21055 nummod STAT3,activation
R10580 T21055 T21052 dobj activation,inhibit
R10581 T21056 T21055 cc and,activation
R10582 T21057 T21058 amod cellular,responses
R10583 T21058 T21055 conj responses,activation
R10584 T21059 T21052 punct ",",inhibit
R10585 T21060 T21062 advmod as,as
R10586 T21061 T21062 advmod well,as
R10587 T21062 T21052 cc as,inhibit
R10588 T21063 T21065 amod IFN-γ-mediated,activation
R10589 T21064 T21065 compound STAT1,activation
R10590 T21065 T21052 dobj activation,inhibit
R10591 T21066 T21068 nmod [,]
R10592 T21067 T21068 nummod 32,]
R10593 T21068 T21065 appos ],activation
R10594 T21069 T21048 punct .,is
R10595 T21070 T21071 aux To,determine
R10596 T21071 T21100 advcl determine,+
R10597 T21072 T21075 mark whether,involved
R10598 T21073 T21075 nsubjpass SOCSs,involved
R10599 T21074 T21075 auxpass were,involved
R10600 T21075 T21071 ccomp involved,determine
R10601 T21076 T21075 prep in,involved
R10602 T21077 T21081 det the,activation
R10603 T21078 T21081 amod defective,activation
R10604 T21079 T21081 amod IL-10-induced,activation
R10605 T21080 T21081 nummod STAT3,activation
R10606 T21081 T21076 pobj activation,in
R10607 T21082 T21081 prep of,activation
R10608 T21083 T21084 compound RA,CD4
R10609 T21084 T21082 pobj CD4,of
R10610 T21085 T21087 amod +,cells
R10611 T21086 T21087 compound T,cells
R10612 T21087 T21081 conj cells,activation
R10613 T21088 T21100 punct ",",+
R10614 T21089 T21090 det the,levels
R10615 T21090 T21100 nsubj levels,+
R10616 T21091 T21090 prep of,levels
R10617 T21092 T21091 pobj SOCS1,of
R10618 T21093 T21092 cc and,SOCS1
R10619 T21094 T21095 compound SOCS3,mRNA
R10620 T21095 T21096 compound mRNA,expression
R10621 T21096 T21090 conj expression,levels
R10622 T21097 T21096 prep in,expression
R10623 T21098 T21099 compound PB,CD4
R10624 T21099 T21097 pobj CD4,in
R10625 T21100 T21100 ROOT +,+
R10626 T21101 T21102 compound T,cells
R10627 T21102 T21100 dobj cells,+
R10628 T21103 T21102 prep from,cells
R10629 T21104 T21106 amod active,patients
R10630 T21105 T21106 compound RA,patients
R10631 T21106 T21103 pobj patients,from
R10632 T21107 T21103 cc and,from
R10633 T21108 T21103 conj from,from
R10634 T21109 T21110 amod healthy,controls
R10635 T21110 T21108 pobj controls,from
R10636 T21111 T21112 auxpass were,compared
R10637 T21112 T21100 prep compared,+
R10638 T21113 T21112 agent by,compared
R10639 T21114 T21116 amod semiquantitative,PCR
R10640 T21115 T21116 amod real-time,PCR
R10641 T21116 T21113 pobj PCR,by
R10642 T21117 T21100 punct .,+
R10643 T21118 T21120 det The,CD4
R10644 T21119 T21120 compound RA,CD4
R10645 T21120 T21124 nsubj CD4,contained
R10646 T21121 T21123 amod +,cells
R10647 T21122 T21123 compound T,cells
R10648 T21123 T21124 nsubj cells,contained
R10649 T21124 T21124 ROOT contained,contained
R10650 T21125 T21126 amod higher,levels
R10651 T21126 T21124 dobj levels,contained
R10652 T21127 T21126 prep of,levels
R10653 T21128 T21127 pobj SOCS1,of
R10654 T21129 T21128 cc but,SOCS1
R10655 T21130 T21131 amod lower,levels
R10656 T21131 T21127 pobj levels,of
R10657 T21132 T21131 prep of,levels
R10658 T21133 T21134 nummod SOCS3,transcripts
R10659 T21134 T21132 pobj transcripts,of
R10660 T21135 T21137 mark than,control
R10661 T21136 T21137 aux did,control
R10662 T21137 T21124 advcl control,contained
R10663 T21138 T21141 nmod CD4,cells
R10664 T21139 T21141 nummod +,cells
R10665 T21140 T21141 compound T,cells
R10666 T21141 T21137 dobj cells,control
R10667 T21142 T21141 punct (,cells
R10668 T21143 T21144 compound Fig.,6a
R10669 T21144 T21141 appos 6a,cells
R10670 T21145 T21141 punct ),cells
R10671 T21146 T21124 punct .,contained
R10672 T21147 T21148 amod Constitutive,expression
R10673 T21148 T21158 nsubj expression,was
R10674 T21149 T21148 prep of,expression
R10675 T21150 T21151 nummod SOCS1,mRNA
R10676 T21151 T21157 nmod mRNA,cells
R10677 T21152 T21151 prep in,mRNA
R10678 T21153 T21154 compound RA,CD4
R10679 T21154 T21152 pobj CD4,in
R10680 T21155 T21157 amod +,cells
R10681 T21156 T21157 compound T,cells
R10682 T21157 T21149 pobj cells,of
R10683 T21158 T21158 ROOT was,was
R10684 T21159 T21158 acomp comparable,was
R10685 T21160 T21159 prep with,comparable
R10686 T21161 T21162 det the,expression
R10687 T21162 T21160 pobj expression,with
R10688 T21163 T21162 prep in,expression
R10689 T21164 T21168 amod normal,cells
R10690 T21165 T21168 compound CD4,cells
R10691 T21166 T21168 nummod +,cells
R10692 T21167 T21168 compound T,cells
R10693 T21168 T21163 pobj cells,in
R10694 T21169 T21162 acl stimulated,expression
R10695 T21170 T21169 agent by,stimulated
R10696 T21171 T21173 nummod 10,IL-6
R10697 T21172 T21173 compound ng/ml,IL-6
R10698 T21173 T21170 pobj IL-6,by
R10699 T21174 T21175 punct (,Fig.
R10700 T21175 T21173 appos Fig.,IL-6
R10701 T21176 T21175 nummod 6b,Fig.
R10702 T21177 T21175 punct ),Fig.
R10703 T21178 T21158 punct ",",was
R10704 T21179 T21158 advcl supporting,was
R10705 T21180 T21182 poss its,significance
R10706 T21181 T21182 amod functional,significance
R10707 T21182 T21179 dobj significance,supporting
R10708 T21183 T21158 punct .,was
R10709 T21184 T21187 amod Defective,activation
R10710 T21185 T21187 amod IL-10-induced,activation
R10711 T21186 T21187 nummod STAT3,activation
R10712 T21187 T21189 nsubj activation,appears
R10713 T21188 T21189 advmod therefore,appears
R10714 T21189 T21189 ROOT appears,appears
R10715 T21190 T21191 aux to,be
R10716 T21191 T21189 xcomp be,appears
R10717 T21192 T21191 acomp due,be
R10718 T21193 T21194 advmod at,least
R10719 T21194 T21195 advmod least,in
R10720 T21195 T21192 prep in,due
R10721 T21196 T21195 pobj part,in
R10722 T21197 T21191 prep to,be
R10723 T21198 T21199 det an,abundance
R10724 T21199 T21197 pobj abundance,to
R10725 T21200 T21199 prep of,abundance
R10726 T21201 T21200 pobj SOCS1,of
R10727 T21202 T21199 prep in,abundance
R10728 T21203 T21204 compound RA,CD4
R10729 T21204 T21202 pobj CD4,in
R10730 T21205 T21207 amod +,cells
R10731 T21206 T21207 compound T,cells
R10732 T21207 T21197 pobj cells,to
R10733 T21208 T21189 punct .,appears
R13597 T26799 T26803 nsubj CD4,orchestrate
R13599 T26800 T26802 nummod +,cells
R13601 T26801 T26802 compound T,cells
R13603 T26802 T26803 nsubj cells,orchestrate
R13605 T26803 T26803 ROOT orchestrate,orchestrate
R13606 T26804 T26808 det the,response
R13608 T26805 T26808 amod Th1-type,response
R13610 T26806 T26808 amod cell-mediated,response
R13611 T26807 T26808 amod immune,response
R13612 T26808 T26803 dobj response,orchestrate
R13613 T26809 T26808 prep in,response
R13614 T26810 T26811 compound RA,[
R13615 T26811 T26809 pobj [,in
R13616 T26877 T26879 det the,ligands
R13617 T26878 T26879 compound CD28,ligands
R13618 T26879 T26895 nsubjpass ligands,expressed
R13619 T26880 T26879 punct ",",ligands
R13620 T26812 T26813 nummod 22,]
R13621 T26881 T26882 det both,CD80
R13622 T26882 T26879 conj CD80,ligands
R13623 T26883 T26882 cc and,CD80
R13624 T26813 T26811 appos ],[
R13625 T26884 T26882 conj CD86,CD80
R13626 T26885 T26879 punct ",",ligands
R13627 T26814 T26803 punct .,orchestrate
R13628 T26815 T26819 amod Activated,cells
R13629 T26886 T26887 advmod together,with
R13630 T26816 T26819 compound CD4,cells
R13631 T26887 T26879 prep with,ligands
R13632 T26817 T26819 nummod +,cells
R13633 T26888 T26891 compound MHC,antigens
R13634 T26889 T26891 compound class,antigens
R13635 T26890 T26891 compound II,antigens
R13636 T26818 T26819 compound T,cells
R13637 T26891 T26887 pobj antigens,with
R13638 T26892 T26895 punct ",",expressed
R13639 T26893 T26895 auxpass are,expressed
R13640 T26819 T26820 nsubj cells,stimulate
R13641 T26894 T26895 advmod substantially,expressed
R13642 T26895 T26895 ROOT expressed,expressed
R13643 T26820 T26820 ROOT stimulate,stimulate
R13644 T26821 T26820 dobj macrophages,stimulate
R13645 T26896 T26895 agent by,expressed
R13646 T26822 T26821 punct ",",macrophages
R13647 T26897 T26898 amod antigen-presenting,cells
R13648 T26898 T26896 pobj cells,by
R13649 T26899 T26900 amod such,as
R13650 T26823 T26824 amod synovial,fibroblasts
R13651 T26900 T26898 prep as,cells
R13652 T26901 T26900 pobj macrophages,as
R13653 T26824 T26821 conj fibroblasts,macrophages
R13654 T26902 T26901 cc and,macrophages
R13655 T26903 T26904 amod dendritic,cells
R13656 T26904 T26901 conj cells,macrophages
R13657 T26905 T26907 nmod [,]
R13658 T26825 T26824 punct ",",fibroblasts
R13659 T26906 T26907 nummod 18-20,]
R13660 T26907 T26901 conj ],macrophages
R13661 T26908 T26895 punct .,expressed
R13662 T26826 T26827 compound B,cells
R13663 T26909 T26910 det The,significance
R13664 T26910 T26922 nsubjpass significance,proven
R13665 T26911 T26910 prep of,significance
R13666 T26827 T26824 conj cells,fibroblasts
R13667 T26912 T26913 nummod CD28,engagement
R13668 T26913 T26911 pobj engagement,of
R13669 T26914 T26913 prep in,engagement
R13670 T26915 T26918 det the,process
R13671 T26916 T26918 amod T-cell-mediated,process
R13672 T26917 T26918 compound disease,process
R13673 T26828 T26827 punct ",",cells
R13674 T26918 T26914 pobj process,in
R13675 T26919 T26922 aux has,proven
R13676 T26920 T26922 advmod recently,proven
R13677 T26921 T26922 auxpass been,proven
R13678 T26829 T26827 cc and,cells
R13679 T26922 T26922 ROOT proven,proven
R13680 T26923 T26922 agent by,proven
R13681 T26924 T26926 det the,efficacy
R13682 T26830 T26827 conj osteoclasts,cells
R13683 T26925 T26926 amod clinical,efficacy
R13684 T26926 T26923 pobj efficacy,by
R13685 T26831 T26820 prep through,stimulate
R13686 T26927 T26926 prep of,efficacy
R13687 T26928 T26932 poss its,antigen
R13688 T26929 T26932 nmod blocker,antigen
R13689 T26832 T26833 det the,expression
R13690 T26930 T26932 nmod cytotoxic,antigen
R13691 T26931 T26932 amod T-cell-associated,antigen
R13692 T26932 T26927 pobj antigen,of
R13693 T26833 T26831 pobj expression,through
R13694 T26933 T26932 nummod 4,antigen
R13695 T26934 T26932 punct (,antigen
R13696 T26834 T26833 prep of,expression
R13697 T26935 T26932 appos CD152,antigen
R13698 T26936 T26932 punct ),antigen
R13699 T26937 T26938 punct -,IgG
R13700 T26835 T26836 compound cell,surface
R13701 T26836 T26837 compound surface,molecules
R13702 T26938 T26926 appos IgG,efficacy
R13703 T26939 T26938 prep in,IgG
R13704 T26940 T26941 compound RA,patients
R13705 T26837 T26834 pobj molecules,of
R13706 T26941 T26939 pobj patients,in
R13707 T26942 T26944 nmod [,]
R13708 T26838 T26837 cc and,molecules
R13709 T26943 T26944 nummod 23,]
R13710 T26944 T26938 conj ],IgG
R13711 T26945 T26922 punct .,proven
R13712 T26839 T26840 amod Th1,cytokines
R13713 T26946 T26947 nsubj IL-10,plays
R13714 T26947 T26947 ROOT plays,plays
R13715 T26840 T26837 conj cytokines,molecules
R13716 T26948 T26950 det a,role
R13717 T26949 T26950 amod predominant,role
R13718 T26950 T26947 dobj role,plays
R13719 T26951 T26950 prep in,role
R13720 T26952 T26951 pcomp limiting,in
R13721 T26953 T26956 amod immune,responses
R13722 T26841 T26820 punct ",",stimulate
R13723 T26954 T26953 cc and,immune
R13724 T26955 T26953 conj inflammatory,immune
R13725 T26956 T26952 dobj responses,limiting
R13726 T26842 T26843 advmod thereby,contributing
R13727 T26957 T26952 prep by,limiting
R13728 T26958 T26957 pcomp regulating,by
R13729 T26959 T26960 det the,function
R13730 T26843 T26820 advcl contributing,stimulate
R13731 T26960 T26958 dobj function,regulating
R13732 T26961 T26960 prep of,function
R13733 T26962 T26963 det both,macrophages
R13734 T26844 T26843 prep to,contributing
R13735 T26963 T26961 pobj macrophages,of
R13736 T26964 T26963 cc and,macrophages
R13737 T26965 T26966 amod Th1,cells
R13738 T26845 T26848 preconj both,inflammation
R13739 T26966 T26963 conj cells,macrophages
R13740 T26967 T26947 conj [,plays
R13741 T26968 T26969 nummod 1,]
R13742 T26846 T26848 det the,inflammation
R13743 T26969 T26967 dobj ],[
R13744 T26970 T26947 punct .,plays
R13745 T26971 T26972 nsubj IL-10,inhibits
R13746 T26847 T26848 amod chronic,inflammation
R13747 T26972 T26972 ROOT inhibits,inhibits
R13748 T26848 T26844 pobj inflammation,to
R13749 T26849 T26848 cc and,inflammation
R13750 T26973 T26975 det the,phosphorylation
R13751 T26850 T26852 det the,destruction
R13752 T26974 T26975 compound tyrosine,phosphorylation
R13753 T26975 T26972 dobj phosphorylation,inhibits
R13754 T26976 T26975 prep of,phosphorylation
R13755 T26851 T26852 amod joint,destruction
R13756 T26977 T26979 det the,molecule
R13757 T26978 T26979 compound CD28,molecule
R13758 T26979 T26976 pobj molecule,of
R13759 T26852 T26848 conj destruction,inflammation
R13760 T26980 T26975 cc and,phosphorylation
R13761 T26981 T26985 det the,binding
R13762 T26982 T26985 amod subsequent,binding
R13763 T26853 T26820 punct .,stimulate
R13764 T26983 T26985 advmod phosphatidylinositol,binding
R13765 T26984 T26985 advmod 3-kinase,binding
R13766 T26985 T26975 conj binding,phosphorylation
R13767 T26854 T26858 nsubj CD4,require
R13768 T26986 T26985 prep in,binding
R13769 T26987 T26988 compound T,cells
R13770 T26988 T26986 pobj cells,in
R13771 T26989 T26985 punct ",",binding
R13772 T26990 T26985 cc and,binding
R13773 T26991 T26993 advmod thereby,acts
R13774 T26855 T26857 nummod +,cells
R13775 T26856 T26857 compound T,cells
R13776 T26857 T26858 nsubj cells,require
R13777 T26858 T26858 ROOT require,require
R13778 T26992 T26993 advmod directly,acts
R13779 T26993 T26972 conj acts,inhibits
R13780 T26994 T26993 prep on,acts
R13781 T26859 T26860 nummod two,signals
R13782 T26995 T26996 compound T,cells
R13783 T26996 T26994 pobj cells,on
R13784 T26860 T26858 dobj signals,require
R13785 T26997 T26999 nmod [,]
R13786 T26998 T26999 nummod 24,]
R13787 T26999 T26996 appos ],cells
R13788 T27000 T26972 punct .,inhibits
R13789 T26861 T26863 aux to,activated
R13790 T27001 T27007 prep In,found
R13791 T27002 T27004 det the,study
R13792 T26862 T26863 auxpass be,activated
R13793 T27003 T27004 amod present,study
R13794 T27004 T27001 pobj study,In
R13795 T27005 T27007 punct ",",found
R13796 T26863 T26860 relcl activated,signals
R13797 T27006 T27007 nsubj we,found
R13798 T27007 T27007 ROOT found,found
R13799 T27008 T27011 mark that,+
R13800 T26864 T26860 punct ;,signals
R13801 T27009 T27010 compound PB,CD4
R13802 T27010 T27011 nsubj CD4,+
R13803 T26865 T26867 compound antigen,occupancy
R13804 T27011 T27026 advcl +,are
R13805 T27012 T27013 compound T,cells
R13806 T27013 T27011 dobj cells,+
R13807 T27014 T27011 prep from,+
R13808 T26866 T26867 compound receptor,occupancy
R13809 T27015 T27014 pobj patients,from
R13810 T27016 T27015 prep with,patients
R13811 T26867 T26860 appos occupancy,signals
R13812 T26868 T26867 cc and,occupancy
R13813 T27017 T27018 amod active,RA
R13814 T27018 T27016 pobj RA,with
R13815 T26869 T26870 amod CD28-mediated,costimulation
R13816 T27019 T27026 punct ",",are
R13817 T27020 T27026 prep in,are
R13818 T27021 T27022 det the,presence
R13819 T27022 T27020 pobj presence,in
R13820 T27023 T27022 prep of,presence
R13821 T27024 T27023 pobj IL-10,of
R13822 T26870 T26867 conj costimulation,occupancy
R13823 T27025 T27026 punct ",",are
R13824 T27026 T27007 ccomp are,found
R13825 T26871 T26858 punct .,require
R13826 T27027 T27026 acomp able,are
R13827 T27028 T27029 aux to,produce
R13828 T27029 T27027 xcomp produce,able
R13829 T27030 T27031 amod higher,levels
R13830 T26872 T26895 prep In,expressed
R13831 T27031 T27029 dobj levels,produce
R13832 T27032 T27031 prep of,levels
R13833 T27033 T27032 pobj IFN-γ,of
R13834 T26873 T26875 det the,lesion
R13835 T27034 T27029 prep after,produce
R13836 T27035 T27034 pobj CD3,after
R13837 T26874 T26875 compound ST,lesion
R13838 T27036 T27035 cc and,CD3
R13839 T27037 T27038 compound CD28,costimulation
R13840 T27038 T27035 conj costimulation,CD3
R13841 T26875 T26872 pobj lesion,In
R13842 T27039 T27038 prep than,costimulation
R13843 T27040 T27044 amod normal,cells
R13844 T26876 T26895 punct ",",expressed
R13845 T27041 T27044 compound CD4,cells
R13846 T27042 T27044 nummod +,cells
R13847 T27043 T27044 compound T,cells
R13848 T27044 T27039 pobj cells,than
R13849 T27073 T27076 compound CD4,cells
R13850 T27045 T27007 punct .,found
R13851 T27046 T27061 prep Despite,suppressed
R13852 T27047 T27049 amod high-level,expression
R13853 T27074 T27076 nummod +,cells
R13854 T27048 T27049 compound IL-10R1,expression
R13855 T27049 T27046 pobj expression,Despite
R13856 T27050 T27049 cc and,expression
R13857 T27075 T27076 compound T,cells
R13858 T27051 T27053 amod constitutive,activation
R13859 T27052 T27053 nummod STAT3,activation
R13860 T27053 T27049 conj activation,expression
R13861 T27076 T27071 pobj cells,to
R13862 T27054 T27053 punct ",",activation
R13863 T27055 T27057 nmod IL-10-induced,phosphorylation
R13864 T27056 T27057 compound tyrosine,phosphorylation
R13865 T27077 T27076 punct ",",cells
R13866 T27057 T27053 conj phosphorylation,activation
R13867 T27058 T27057 prep of,phosphorylation
R13868 T27059 T27058 pobj STAT3,of
R13869 T27060 T27061 auxpass is,suppressed
R13870 T27061 T27061 ROOT suppressed,suppressed
R13871 T27062 T27061 prep in,suppressed
R13872 T27063 T27064 compound RA,CD4
R13873 T27078 T27081 advmod where,is
R13874 T27064 T27062 pobj CD4,in
R13875 T27065 T27067 amod +,cells
R13876 T27066 T27067 compound T,cells
R13877 T27079 T27080 compound STAT3,phosphorylation
R13878 T27067 T27061 dobj cells,suppressed
R13879 T27068 T27061 punct ",",suppressed
R13880 T27069 T27061 prep in,suppressed
R13881 T27080 T27081 nsubj phosphorylation,is
R13882 T27070 T27069 pobj contrast,in
R13883 T27071 T27070 prep to,contrast
R13884 T27072 T27076 amod normal,cells
R13885 T27081 T27076 relcl is,cells
R13886 T27082 T27083 advmod dose-dependently,inducible
R13887 T27083 T27081 acomp inducible,is
R13888 T27084 T27083 prep by,inducible
R13889 T27088 T27092 nsubj IL-6,induces
R13890 T27089 T27088 prep from,IL-6
R13891 T27085 T27084 pobj IL-10,by
R13892 T27090 T27091 compound RA,patients
R13893 T27091 T27089 pobj patients,from
R13894 T27092 T27092 ROOT induces,induces
R13895 T27086 T27061 punct .,suppressed
R13896 T27093 T27092 dobj STAT3,induces
R13897 T27094 T27093 cc but,STAT3
R13898 T27095 T27097 neg not,phosphorylation
R13899 T27087 T27088 compound Serum,IL-6
R13900 T27182 T27181 pobj association,in
R13901 T27096 T27097 nummod STAT1,phosphorylation
R13902 T27097 T27108 nsubj phosphorylation,induces
R13903 T27183 T27182 prep with,association
R13904 T27098 T27097 prep in,phosphorylation
R13905 T27099 T27103 amod normal,cells
R13906 T27100 T27103 compound CD4,cells
R13907 T27101 T27103 nummod +,cells
R13908 T27184 T27186 amod sustained,phosphorylation
R13909 T27185 T27186 compound STAT3,phosphorylation
R13910 T27102 T27103 compound T,cells
R13911 T27186 T27183 pobj phosphorylation,with
R13912 T27103 T27098 pobj cells,in
R13913 T27187 T27186 cc and,phosphorylation
R13914 T27104 T27097 punct ",",phosphorylation
R13915 T27105 T27097 cc and,phosphorylation
R13916 T27106 T27107 amod exogenous,IL-6
R13917 T27107 T27097 conj IL-6,phosphorylation
R13918 T27188 T27189 nummod SOCS1,induction
R13919 T27108 T27092 conj induces,induces
R13920 T27109 T27110 det the,resistance
R13921 T27110 T27108 dobj resistance,induces
R13922 T27111 T27110 prep to,resistance
R13923 T27112 T27113 compound IL-10,inhibition
R13924 T27113 T27111 pobj inhibition,to
R13925 T27189 T27186 conj induction,phosphorylation
R13926 T27114 T27113 prep of,inhibition
R13927 T27115 T27116 amod IFN-γ,production
R13928 T27116 T27114 pobj production,of
R13929 T27190 T27146 punct .,indicate
R13930 T27117 T27108 punct .,induces
R13931 T27118 T27119 compound RA,CD4
R13932 T27119 T27122 compound CD4,cells
R13933 T27191 T27192 amod IL-10-mediated,inhibition
R13934 T27120 T27122 amod +,cells
R13935 T27121 T27122 compound T,cells
R13936 T27192 T27199 nsubj inhibition,is
R13937 T27122 T27123 nsubj cells,contain
R13938 T27123 T27123 ROOT contain,contain
R13939 T27124 T27125 amod higher,levels
R13940 T27193 T27192 prep of,inhibition
R13941 T27125 T27123 dobj levels,contain
R13942 T27126 T27125 prep of,levels
R13943 T27127 T27126 pobj SOCS1,of
R13944 T27194 T27198 compound CD4,production
R13945 T27128 T27123 cc but,contain
R13946 T27129 T27123 conj contain,contain
R13947 T27130 T27131 amod lower,levels
R13948 T27195 T27198 compound +,production
R13949 T27131 T27129 dobj levels,contain
R13950 T27132 T27131 prep of,levels
R13951 T27133 T27134 nummod SOCS3,transcripts
R13952 T27196 T27198 compound T-cell,production
R13953 T27197 T27198 compound cytokine,production
R13954 T27134 T27132 pobj transcripts,of
R13955 T27135 T27129 prep in,contain
R13956 T27198 T27193 pobj production,of
R13957 T27136 T27135 pobj comparison,in
R13958 T27137 T27136 prep with,comparison
R13959 T27138 T27142 amod normal,cells
R13960 T27199 T27199 ROOT is,is
R13961 T27139 T27142 compound CD4,cells
R13962 T27140 T27142 nummod +,cells
R13963 T27200 T27201 advmod principally,dependent
R13964 T27141 T27142 compound T,cells
R13965 T27142 T27137 pobj cells,with
R13966 T27143 T27123 punct .,contain
R13967 T27201 T27199 acomp dependent,is
R13968 T27144 T27145 det These,findings
R13969 T27145 T27146 nsubj findings,indicate
R13970 T27146 T27146 ROOT indicate,indicate
R13971 T27147 T27152 mark that,become
R13972 T27148 T27152 nsubj CD4,become
R13973 T27202 T27201 prep on,dependent
R13974 T27149 T27151 nummod +,cells
R13975 T27150 T27151 compound T,cells
R13976 T27151 T27152 nsubj cells,become
R13977 T27152 T27146 ccomp become,indicate
R13978 T27203 T27204 poss its,inhibition
R13979 T27153 T27152 acomp resistant,become
R13980 T27154 T27153 prep to,resistant
R13981 T27155 T27157 det the,effect
R13982 T27204 T27202 pobj inhibition,on
R13983 T27156 T27157 amod inhibitory,effect
R13984 T27157 T27154 pobj effect,to
R13985 T27158 T27157 prep of,effect
R13986 T27205 T27204 prep of,inhibition
R13987 T27159 T27158 pobj IL-10,of
R13988 T27160 T27152 prep before,become
R13989 T27161 T27160 pobj migration,before
R13990 T27206 T27209 nmod macrophage,function
R13991 T27162 T27161 prep into,migration
R13992 T27163 T27165 det the,ST
R13993 T27164 T27165 amod inflamed,ST
R13994 T27207 T27209 amod antigen-presenting,function
R13995 T27165 T27162 pobj ST,into
R13996 T27166 T27152 punct ",",become
R13997 T27167 T27152 cc and,become
R13998 T27208 T27209 compound cell,function
R13999 T27168 T27152 conj suggest,become
R14000 T27169 T27173 mark that,be
R14001 T27209 T27205 pobj function,of
R14002 T27170 T27171 det this,resistance
R14003 T27171 T27173 nsubj resistance,be
R14004 T27172 T27173 aux may,be
R14005 T27173 T27168 ccomp be,suggest
R14006 T27210 T27212 nmod [,]
R14007 T27174 T27173 acomp attributable,be
R14008 T27175 T27174 prep to,attributable
R14009 T27176 T27179 amod impaired,activation
R14010 T27211 T27212 nummod 1,]
R14011 T27177 T27179 amod IL-10-dependent,activation
R14012 T27178 T27179 nummod STAT3,activation
R14013 T27212 T27204 appos ],inhibition
R14014 T27179 T27175 pobj activation,to
R14015 T27180 T27173 punct ",",be
R14016 T27181 T27173 prep in,be
R14017 T27213 T27199 punct .,is
R14018 T27214 T27221 advmod However,thought
R14019 T27215 T27221 punct ",",thought
R14020 T27280 T27265 punct .,shown
R14021 T27281 T27283 det This,effect
R14022 T27282 T27283 amod direct,effect
R14023 T27216 T27219 det this,effect
R14024 T27283 T27287 nsubjpass effect,limited
R14025 T27284 T27287 advmod also,limited
R14026 T27217 T27219 amod indirect,effect
R14027 T27285 T27287 aux may,limited
R14028 T27286 T27287 auxpass be,limited
R14029 T27287 T27287 ROOT limited,limited
R14030 T27288 T27287 prep in,limited
R14031 T27218 T27219 amod inhibitory,effect
R14032 T27289 T27291 amod active,patients
R14033 T27290 T27291 compound RA,patients
R14034 T27219 T27221 nsubjpass effect,thought
R14035 T27291 T27288 pobj patients,in
R14036 T27220 T27221 auxpass is,thought
R14037 T27221 T27221 ROOT thought,thought
R14038 T27222 T27224 aux to,restricted
R14039 T27292 T27287 punct ",",limited
R14040 T27223 T27224 auxpass be,restricted
R14041 T27293 T27300 mark because,showed
R14042 T27294 T27296 poss their,CD4
R14043 T27295 T27296 compound PB,CD4
R14044 T27224 T27221 xcomp restricted,thought
R14045 T27296 T27299 nmod CD4,cells
R14046 T27297 T27299 amod +,cells
R14047 T27225 T27224 prep at,restricted
R14048 T27298 T27299 compound T,cells
R14049 T27299 T27300 nsubj cells,showed
R14050 T27300 T27287 advcl showed,limited
R14051 T27226 T27227 det the,site
R14052 T27227 T27225 pobj site,at
R14053 T27228 T27227 prep of,site
R14054 T27301 T27304 det a,inhibition
R14055 T27302 T27304 amod defective,inhibition
R14056 T27229 T27230 compound T-cell,activation
R14057 T27303 T27304 compound IL-10,inhibition
R14058 T27304 T27300 dobj inhibition,showed
R14059 T27305 T27304 prep of,inhibition
R14060 T27230 T27228 pobj activation,of
R14061 T27306 T27307 amod CD28-costimulated,production
R14062 T27307 T27305 pobj production,of
R14063 T27231 T27230 prep in,activation
R14064 T27308 T27307 prep of,production
R14065 T27309 T27310 preconj both,IFN-γ
R14066 T27310 T27308 pobj IFN-γ,of
R14067 T27232 T27231 pobj RA,in
R14068 T27311 T27310 cc and,IFN-γ
R14069 T27312 T27310 conj IL-2,IFN-γ
R14070 T27313 T27287 punct .,limited
R14071 T27314 T27315 amod Numerous,cytokines
R14072 T27315 T27324 nsubj cytokines,detected
R14073 T27233 T27221 punct ",",thought
R14074 T27316 T27315 punct ",",cytokines
R14075 T27317 T27318 preconj both,proinflammatory
R14076 T27318 T27315 conj proinflammatory,cytokines
R14077 T27319 T27318 cc and,proinflammatory
R14078 T27234 T27239 mark because,express
R14079 T27320 T27318 conj anti-inflammatory,proinflammatory
R14080 T27321 T27324 punct ",",detected
R14081 T27235 T27239 nsubj macrophages,express
R14082 T27322 T27324 aux have,detected
R14083 T27323 T27324 auxpass been,detected
R14084 T27324 T27324 ROOT detected,detected
R14085 T27236 T27235 prep in,macrophages
R14086 T27325 T27324 prep in,detected
R14087 T27326 T27327 det the,ST
R14088 T27237 T27238 det the,ST
R14089 T27327 T27325 pobj ST,in
R14090 T27328 T27327 prep of,ST
R14091 T27329 T27328 pobj RA,of
R14092 T27238 T27236 pobj ST,in
R14093 T27330 T27324 punct ",",detected
R14094 T27331 T27324 cc and,detected
R14095 T27239 T27221 advcl express,thought
R14096 T27332 T27333 det the,balance
R14097 T27333 T27339 nsubj balance,regulates
R14098 T27240 T27241 amod high,levels
R14099 T27334 T27333 prep between,balance
R14100 T27335 T27338 det these,activities
R14101 T27336 T27338 amod opposing,activities
R14102 T27241 T27239 dobj levels,express
R14103 T27337 T27338 compound cytokine,activities
R14104 T27338 T27334 pobj activities,between
R14105 T27339 T27324 conj regulates,detected
R14106 T27242 T27241 prep of,levels
R14107 T27340 T27341 compound disease,severity
R14108 T27341 T27339 dobj severity,regulates
R14109 T27342 T27344 nmod [,]
R14110 T27243 T27242 pobj cytokines,of
R14111 T27343 T27344 nummod 10,]
R14112 T27344 T27339 dobj ],regulates
R14113 T27244 T27243 punct ",",cytokines
R14114 T27345 T27339 punct .,regulates
R14115 T27346 T27347 compound Endogenous,IL-10
R14116 T27347 T27349 nsubj IL-10,produced
R14117 T27245 T27243 conj CD80,cytokines
R14118 T27348 T27349 punct ",",produced
R14119 T27349 T27349 ROOT produced,produced
R14120 T27246 T27245 cc and,CD80
R14121 T27350 T27351 advmod mainly,by
R14122 T27351 T27349 prep by,produced
R14123 T27352 T27351 pobj macrophages,by
R14124 T27353 T27352 cc and,macrophages
R14125 T27354 T27355 compound T,cells
R14126 T27355 T27352 conj cells,macrophages
R14127 T27356 T27357 punct ",",inhibits
R14128 T27247 T27245 conj CD86,CD80
R14129 T27357 T27349 parataxis inhibits,produced
R14130 T27358 T27360 amod proinflammatory,production
R14131 T27359 T27360 compound cytokine,production
R14132 T27248 T27245 conj molecules,CD80
R14133 T27360 T27357 dobj production,inhibits
R14134 T27249 T27248 punct ",",molecules
R14135 T27250 T27248 cc and,molecules
R14136 T27361 T27360 prep by,production
R14137 T27362 T27363 compound ST,cells
R14138 T27251 T27253 compound MHC,II
R14139 T27363 T27361 pobj cells,by
R14140 T27364 T27366 nmod [,]
R14141 T27365 T27366 nummod 12,]
R14142 T27366 T27357 dobj ],inhibits
R14143 T27252 T27253 compound class,II
R14144 T27367 T27357 punct .,inhibits
R14145 T27368 T27373 advmod However,seems
R14146 T27253 T27254 nsubj II,antigens
R14147 T27369 T27373 punct ",",seems
R14148 T27370 T27372 det this,activity
R14149 T27371 T27372 amod regulatory,activity
R14150 T27254 T27248 conj antigens,molecules
R14151 T27372 T27373 nsubj activity,seems
R14152 T27373 T27373 ROOT seems,seems
R14153 T27255 T27257 compound [,]
R14154 T27374 T27376 aux to,restricted
R14155 T27375 T27376 auxpass be,restricted
R14156 T27256 T27257 compound "10,18-20",]
R14157 T27257 T27254 dobj ],antigens
R14158 T27376 T27373 xcomp restricted,seems
R14159 T27377 T27376 prep during,restricted
R14160 T27258 T27254 punct .,antigens
R14161 T27378 T27379 amod chronic,inflammation
R14162 T27379 T27377 pobj inflammation,during
R14163 T27259 T27260 advmod More,recently
R14164 T27260 T27265 advmod recently,shown
R14165 T27380 T27373 punct .,seems
R14166 T27381 T27382 det The,activation
R14167 T27261 T27265 punct ",",shown
R14168 T27382 T27400 nsubj activation,inhibits
R14169 T27383 T27382 prep of,activation
R14170 T27262 T27265 nsubjpass IL-10,shown
R14171 T27384 T27388 preconj both,kinase
R14172 T27385 T27388 det the,kinase
R14173 T27386 T27388 amod extracellular,kinase
R14174 T27387 T27388 amod stimulus-regulated,kinase
R14175 T27388 T27383 pobj kinase,of
R14176 T27263 T27265 aux has,shown
R14177 T27389 T27388 cc and,kinase
R14178 T27390 T27392 amod p38,pathways
R14179 T27391 T27392 compound kinase,pathways
R14180 T27264 T27265 auxpass been,shown
R14181 T27392 T27388 conj pathways,kinase
R14182 T27393 T27392 punct ",",pathways
R14183 T27394 T27392 acl induced,pathways
R14184 T27265 T27265 ROOT shown,shown
R14185 T27395 T27394 agent by,induced
R14186 T27266 T27267 aux to,induce
R14187 T27267 T27265 xcomp induce,shown
R14188 T27268 T27271 det the,unresponsiveness
R14189 T27396 T27395 pobj TNF-α,by
R14190 T27397 T27396 cc and,TNF-α
R14191 T27269 T27271 amod antigen-specific,unresponsiveness
R14192 T27398 T27396 conj IL-1,TNF-α
R14193 T27399 T27400 punct ",",inhibits
R14194 T27400 T27400 ROOT inhibits,inhibits
R14195 T27270 T27271 compound T-cell,unresponsiveness
R14196 T27401 T27402 det the,Jak1
R14197 T27402 T27400 dobj Jak1,inhibits
R14198 T27403 T27405 nummod STAT3,pathway
R14199 T27271 T27267 dobj unresponsiveness,induce
R14200 T27404 T27405 amod signaling,pathway
R14201 T27405 T27402 appos pathway,Jak1
R14202 T27272 T27267 prep by,induce
R14203 T27406 T27405 acl shared,pathway
R14204 T27407 T27406 agent by,shared
R14205 T27408 T27407 pobj IL-10,by
R14206 T27273 T27272 pcomp inhibiting,by
R14207 T27274 T27276 nmod CD28,phosphorylation
R14208 T27409 T27408 cc and,IL-10
R14209 T27275 T27276 compound tyrosine,phosphorylation
R14210 T27410 T27408 conj IL-6,IL-10
R14211 T27411 T27406 prep in,shared
R14212 T27412 T27413 amod adhered,macrophages
R14213 T27276 T27277 compound phosphorylation,[
R14214 T27413 T27411 pobj macrophages,in
R14215 T27414 T27411 pobj [,in
R14216 T27415 T27416 nummod 13,]
R14217 T27416 T27414 appos ],[
R14218 T27277 T27273 dobj [,inhibiting
R14219 T27417 T27400 punct .,inhibits
R14220 T27418 T27419 advmod More,importantly
R14221 T27278 T27279 nummod 33,]
R14222 T27419 T27424 advmod importantly,is
R14223 T27420 T27424 punct ",",is
R14224 T27421 T27423 amod IL-10-mediated,activation
R14225 T27422 T27423 nummod STAT3,activation
R14226 T27423 T27424 nsubj activation,is
R14227 T27424 T27424 ROOT is,is
R14228 T27279 T27277 appos ],[
R14229 T27425 T27426 advmod mostly,undetectable
R14230 T27426 T27424 acomp undetectable,is
R14231 T27427 T27426 prep in,undetectable
R14232 T27428 T27427 pobj RA,in
R14233 T27472 T27479 det the,]
R14234 T27429 T27430 amod synovial,macrophages
R14235 T27430 T27424 attr macrophages,is
R14236 T27473 T27474 compound IgG,Fc
R14237 T27431 T27424 punct .,is
R14238 T27432 T27434 det This,IL-10
R14239 T27433 T27434 amod impaired,IL-10
R14240 T27474 T27479 compound Fc,]
R14241 T27434 T27438 nsubjpass IL-10,induced
R14242 T27435 T27438 nsubjpass signaling,induced
R14243 T27436 T27438 auxpass is,induced
R14244 T27475 T27476 compound gamma,receptor
R14245 T27437 T27438 advmod probably,induced
R14246 T27438 T27438 ROOT induced,induced
R14247 T27439 T27438 agent by,induced
R14248 T27476 T27479 compound receptor,]
R14249 T27440 T27441 amod chronic,exposure
R14250 T27441 T27439 pobj exposure,by
R14251 T27442 T27441 prep to,exposure
R14252 T27477 T27479 nmod [,]
R14253 T27443 T27444 amod immune,complexes
R14254 T27444 T27442 pobj complexes,to
R14255 T27478 T27479 nummod 14,]
R14256 T27445 T27444 prep in,complexes
R14257 T27446 T27445 pobj vivo,in
R14258 T27447 T27438 punct ",",induced
R14259 T27448 T27459 mark because,suppressed
R14260 T27479 T27471 pobj ],of
R14261 T27449 T27453 preconj both,expression
R14262 T27450 T27451 compound cell,surface
R14263 T27480 T27438 punct .,induced
R14264 T27481 T27489 advmod Furthermore,are
R14265 T27451 T27452 compound surface,IL-10R1
R14266 T27452 T27453 compound IL-10R1,expression
R14267 T27482 T27489 punct ",",are
R14268 T27453 T27459 nsubjpass expression,suppressed
R14269 T27454 T27453 cc and,expression
R14270 T27455 T27457 amod IL-10-induced,activation
R14271 T27483 T27484 amod dendritic,cells
R14272 T27456 T27457 amod Jak1,activation
R14273 T27457 T27453 conj activation,expression
R14274 T27458 T27459 auxpass are,suppressed
R14275 T27484 T27489 nsubj cells,are
R14276 T27459 T27438 advcl suppressed,induced
R14277 T27460 T27459 prep in,suppressed
R14278 T27461 T27462 amod IFN-γ-primed,macrophages
R14279 T27485 T27484 prep from,cells
R14280 T27462 T27460 pobj macrophages,in
R14281 T27463 T27459 agent by,suppressed
R14282 T27464 T27468 det a,pathway
R14283 T27486 T27488 compound RA,fluids
R14284 T27465 T27468 nmod protein,pathway
R14285 T27466 T27468 nmod kinase,pathway
R14286 T27487 T27488 compound synovial,fluids
R14287 T27467 T27468 compound C-dependent,pathway
R14288 T27488 T27485 pobj fluids,from
R14289 T27468 T27463 pobj pathway,by
R14290 T27489 T27489 ROOT are,are
R14291 T27469 T27468 acl following,pathway
R14292 T27470 T27469 dobj ligation,following
R14293 T27490 T27489 acomp resistant,are
R14294 T27471 T27470 prep of,ligation
R14295 T27491 T27490 prep to,resistant
R14296 T27492 T27494 det the,effect
R14297 T27496 T27495 pobj IL-10,of
R14298 T27493 T27494 amod immunoregulatory,effect
R14299 T27497 T27494 amod due,effect
R14300 T27498 T27497 pcomp to,due
R14301 T27494 T27491 pobj effect,to
R14302 T27499 T27500 amod decreased,transport
R14303 T27500 T27497 pobj transport,due
R14304 T27501 T27500 prep of,transport
R14305 T27502 T27503 amod intracellular,IL-10R1
R14306 T27495 T27494 prep of,effect
R14307 T27503 T27501 pobj IL-10R1,of
R14308 T27504 T27500 prep in,transport
R14309 T27568 T27567 prep at,modulated
R14310 T27505 T27506 det the,presence
R14311 T27506 T27504 pobj presence,in
R14312 T27569 T27572 det the,level
R14313 T27507 T27506 prep of,presence
R14314 T27508 T27510 amod proinflammatory,stimuli
R14315 T27509 T27510 compound cytokine,stimuli
R14316 T27570 T27572 nmod signal,level
R14317 T27510 T27507 pobj stimuli,of
R14318 T27511 T27512 amod such,as
R14319 T27512 T27510 prep as,stimuli
R14320 T27571 T27572 compound transduction,level
R14321 T27513 T27512 pobj TNF-α,as
R14322 T27514 T27513 punct ",",TNF-α
R14323 T27515 T27513 conj IL-1,TNF-α
R14324 T27516 T27515 punct ",",IL-1
R14325 T27517 T27515 cc and,IL-1
R14326 T27518 T27515 conj granulocyte,IL-1
R14327 T27572 T27568 pobj level,at
R14328 T27519 T27521 compound macrophage,factor
R14329 T27520 T27521 compound colony-stimulating,factor
R14330 T27521 T27489 attr factor,are
R14331 T27573 T27567 prep under,modulated
R14332 T27522 T27524 nmod [,]
R14333 T27523 T27524 nummod 15,]
R14334 T27524 T27521 appos ],factor
R14335 T27574 T27576 det the,environment
R14336 T27525 T27489 punct .,are
R14337 T27526 T27528 nsubj We,demonstrated
R14338 T27575 T27576 amod inflammatory,environment
R14339 T27576 T27573 pobj environment,under
R14340 T27527 T27528 aux have,demonstrated
R14341 T27577 T27567 prep in,modulated
R14342 T27528 T27528 ROOT demonstrated,demonstrated
R14343 T27529 T27535 mark that,+
R14344 T27578 T27577 pobj RA,in
R14345 T27530 T27531 det the,resistance
R14346 T27531 T27535 nsubj resistance,+
R14347 T27532 T27531 prep of,resistance
R14348 T27579 T27567 punct .,modulated
R14349 T27533 T27534 compound RA,CD4
R14350 T27534 T27532 pobj CD4,of
R14351 T27580 T27590 prep In,found
R14352 T27535 T27542 csubjpass +,associated
R14353 T27536 T27537 compound T,cells
R14354 T27537 T27535 dobj cells,+
R14355 T27538 T27535 prep to,+
R14356 T27581 T27580 pobj association,In
R14357 T27539 T27538 pobj IL-10,to
R14358 T27540 T27542 aux may,associated
R14359 T27582 T27581 prep with,association
R14360 T27541 T27542 auxpass be,associated
R14361 T27542 T27528 ccomp associated,demonstrated
R14362 T27543 T27542 prep with,associated
R14363 T27544 T27547 amod defective,activation
R14364 T27583 T27586 amod impaired,activation
R14365 T27545 T27547 amod IL-10-dependent,activation
R14366 T27546 T27547 nummod STAT3,activation
R14367 T27584 T27586 amod IL-10-mediated,activation
R14368 T27547 T27543 pobj activation,with
R14369 T27548 T27542 punct ",",associated
R14370 T27549 T27542 cc but,associated
R14371 T27550 T27551 neg not,with
R14372 T27585 T27586 nummod STAT3,activation
R14373 T27551 T27542 conj with,associated
R14374 T27552 T27553 amod IL-10R1,expression
R14375 T27553 T27551 pobj expression,with
R14376 T27554 T27528 punct .,demonstrated
R14377 T27555 T27556 amod Inhibitory,effects
R14378 T27586 T27582 pobj activation,with
R14379 T27556 T27567 nsubjpass effects,modulated
R14380 T27557 T27556 prep of,effects
R14381 T27558 T27557 pobj IL-10,of
R14382 T27587 T27590 punct ",",found
R14383 T27559 T27556 prep on,effects
R14384 T27560 T27563 det these,types
R14385 T27561 T27563 amod inflammatory,types
R14386 T27588 T27590 nsubjpass STAT3,found
R14387 T27562 T27563 compound cell,types
R14388 T27563 T27559 pobj types,on
R14389 T27564 T27567 auxpass are,modulated
R14390 T27589 T27590 auxpass was,found
R14391 T27565 T27567 advmod therefore,modulated
R14392 T27566 T27567 advmod differentially,modulated
R14393 T27590 T27590 ROOT found,found
R14394 T27567 T27567 ROOT modulated,modulated
R14395 T27591 T27592 aux to,be
R14396 T27592 T27590 xcomp be,found
R14397 T27601 T27594 punct ),phosphorylated
R14398 T27602 T27594 prep in,phosphorylated
R14399 T27593 T27594 advmod tyrosine,phosphorylated
R14400 T27603 T27604 advmod freshly,isolated
R14401 T27594 T27592 attr phosphorylated,be
R14402 T27604 T27605 amod isolated,PB
R14403 T27605 T27602 pobj PB,in
R14404 T27595 T27594 advmod persistently,phosphorylated
R14405 T27606 T27605 cc and,PB
R14406 T27607 T27605 conj ST,PB
R14407 T27596 T27594 punct (,phosphorylated
R14408 T27608 T27609 compound CD4,+
R14409 T27609 T27590 advcl +,found
R14410 T27610 T27611 compound T,cells
R14411 T27597 T27599 quantmod up,6
R14412 T27611 T27609 dobj cells,+
R14413 T27612 T27609 prep from,+
R14414 T27598 T27599 quantmod to,6
R14415 T27613 T27614 compound RA,patients
R14416 T27614 T27612 pobj patients,from
R14417 T27615 T27590 punct .,found
R14418 T27599 T27600 nummod 6,hours
R14419 T27616 T27618 nsubjpass STAT3,activated
R14420 T27617 T27618 auxpass is,activated
R14421 T27618 T27618 ROOT activated,activated
R14422 T27600 T27594 appos hours,phosphorylated
R14423 T27619 T27618 agent by,activated
R14424 T27620 T27621 det a,variety
R14425 T27621 T27619 pobj variety,by
R14426 T27622 T27621 prep of,variety
R14427 T27623 T27622 pobj cytokines,of
R14428 T27624 T27621 punct ",",variety
R14429 T27656 T27618 punct .,activated
R14430 T27625 T27628 advmod notably,family
R14431 T27626 T27628 det the,family
R14432 T27657 T27662 prep Of,plays
R14433 T27627 T27628 compound IL-6,family
R14434 T27628 T27621 appos family,variety
R14435 T27629 T27628 prep of,family
R14436 T27658 T27659 det these,cytokines
R14437 T27630 T27629 pobj cytokines,of
R14438 T27631 T27633 punct (,IL-6
R14439 T27632 T27633 compound e.g.,IL-6
R14440 T27659 T27657 pobj cytokines,Of
R14441 T27633 T27628 appos IL-6,family
R14442 T27634 T27633 punct ",",IL-6
R14443 T27660 T27662 punct ",",plays
R14444 T27635 T27633 conj IL-11,IL-6
R14445 T27636 T27635 punct ",",IL-11
R14446 T27637 T27639 nmod leukemia,factor
R14447 T27661 T27662 nsubj IL-6,plays
R14448 T27638 T27639 amod inhibitory,factor
R14449 T27639 T27635 appos factor,IL-11
R14450 T27640 T27635 punct ",",IL-11
R14451 T27662 T27662 ROOT plays,plays
R14452 T27641 T27635 cc and,IL-11
R14453 T27642 T27643 compound oncostatin,M
R14454 T27663 T27665 det a,role
R14455 T27643 T27635 conj M,IL-11
R14456 T27644 T27635 punct ),IL-11
R14457 T27645 T27633 cc and,IL-6
R14458 T27664 T27665 amod predominant,role
R14459 T27646 T27647 compound growth,factors
R14460 T27647 T27628 appos factors,family
R14461 T27648 T27628 punct ",",family
R14462 T27665 T27662 dobj role,plays
R14463 T27649 T27628 prep in,family
R14464 T27650 T27649 pobj addition,in
R14465 T27666 T27665 prep in,role
R14466 T27651 T27650 prep to,addition
R14467 T27652 T27651 pobj IL-10,to
R14468 T27653 T27655 nmod [,]
R14469 T27667 T27666 pcomp eliciting,in
R14470 T27654 T27655 nummod 4,]
R14471 T27655 T27652 dobj ],IL-10
R14472 T27668 T27670 det a,reaction
R14473 T27669 T27670 amod systemic,reaction
R14474 T27684 T27685 poss its,abundance
R14475 T27670 T27667 dobj reaction,eliciting
R14476 T27685 T27683 pobj abundance,to
R14477 T27686 T27685 prep in,abundance
R14478 T27671 T27672 amod such,as
R14479 T27687 T27689 det the,circulation
R14480 T27688 T27689 compound blood,circulation
R14481 T27689 T27686 pobj circulation,in
R14482 T27672 T27670 prep as,reaction
R14483 T27690 T27692 nmod [,]
R14484 T27691 T27692 nummod 27,]
R14485 T27673 T27676 det the,response
R14486 T27692 T27670 appos ],reaction
R14487 T27693 T27662 punct .,plays
R14488 T27674 T27676 amod acute,response
R14489 T27694 T27700 advcl Consistent,was
R14490 T27695 T27694 prep with,Consistent
R14491 T27696 T27697 det this,notion
R14492 T27675 T27676 compound phase,response
R14493 T27697 T27695 pobj notion,with
R14494 T27698 T27700 punct ",",was
R14495 T27676 T27672 pobj response,as
R14496 T27699 T27700 nsubj IL-6,was
R14497 T27700 T27700 ROOT was,was
R14498 T27701 T27704 det the,factor
R14499 T27677 T27676 prep in,response
R14500 T27702 T27704 amod major,factor
R14501 T27703 T27704 amod STAT3-activating,factor
R14502 T27678 T27679 amod active,RA
R14503 T27704 T27700 attr factor,was
R14504 T27705 T27704 acl contained,factor
R14505 T27706 T27705 prep in,contained
R14506 T27679 T27677 pobj RA,in
R14507 T27707 T27708 det the,serum
R14508 T27708 T27706 pobj serum,in
R14509 T27709 T27708 prep of,serum
R14510 T27680 T27676 punct ",",response
R14511 T27710 T27712 amod active,patients
R14512 T27711 T27712 compound RA,patients
R14513 T27681 T27670 amod due,reaction
R14514 T27712 T27709 pobj patients,of
R14515 T27682 T27681 advmod mainly,due
R14516 T27713 T27700 punct ",",was
R14517 T27714 T27700 cc and,was
R14518 T27683 T27681 pcomp to,due
R14519 T27715 T27716 det the,responsiveness
R14520 T27716 T27720 nsubjpass responsiveness,suppressed
R14521 T27742 T27743 nummod STAT3,activation
R14522 T27717 T27716 prep to,responsiveness
R14523 T27718 T27717 pobj IL-10,to
R14524 T27719 T27720 auxpass was,suppressed
R14525 T27720 T27700 conj suppressed,was
R14526 T27721 T27720 prep in,suppressed
R14527 T27722 T27726 amod normal,cells
R14528 T27723 T27726 compound CD4,cells
R14529 T27743 T27759 nsubjpass activation,induced
R14530 T27724 T27726 nummod +,cells
R14531 T27725 T27726 compound T,cells
R14532 T27726 T27721 pobj cells,in
R14533 T27727 T27720 prep after,suppressed
R14534 T27744 T27743 cc and,activation
R14535 T27728 T27729 nummod 36,hours
R14536 T27729 T27727 pobj hours,after
R14537 T27730 T27729 prep of,hours
R14538 T27745 T27746 det the,resistance
R14539 T27731 T27730 pobj incubation,of
R14540 T27732 T27720 prep with,suppressed
R14541 T27746 T27743 conj resistance,activation
R14542 T27733 T27732 pobj IL-6,with
R14543 T27734 T27720 punct .,suppressed
R14544 T27735 T27736 det These,results
R14545 T27747 T27746 prep to,resistance
R14546 T27736 T27737 nsubj results,suggest
R14547 T27737 T27737 ROOT suggest,suggest
R14548 T27738 T27759 mark that,induced
R14549 T27748 T27749 compound IL-10,inhibition
R14550 T27739 T27743 preconj both,activation
R14551 T27740 T27743 det the,activation
R14552 T27741 T27743 amod sustained,activation
R14553 T27749 T27747 pobj inhibition,to
R14554 T27750 T27749 acl found,inhibition
R14555 T27751 T27750 prep in,found
R14556 T27752 T27753 compound RA,CD4
R14557 T27753 T27751 pobj CD4,in
R14558 T27839 T27840 det a,defect
R14559 T27840 T27838 dobj defect,showed
R14560 T27754 T27756 amod +,cells
R14561 T27841 T27840 prep in,defect
R14562 T27842 T27846 det the,pathway
R14563 T27755 T27756 compound T,cells
R14564 T27843 T27846 amod IL-10-induced,pathway
R14565 T27844 T27846 nummod STAT3,pathway
R14566 T27845 T27846 amod signaling,pathway
R14567 T27756 T27759 nsubjpass cells,induced
R14568 T27846 T27841 pobj pathway,in
R14569 T27847 T27838 punct .,showed
R14570 T27848 T27849 nsubj It,is
R14571 T27757 T27759 aux may,induced
R14572 T27849 T27849 ROOT is,is
R14573 T27850 T27851 advmod most,probable
R14574 T27851 T27849 acomp probable,is
R14575 T27852 T27865 mark that,augmented
R14576 T27853 T27854 det the,resistance
R14577 T27758 T27759 auxpass be,induced
R14578 T27854 T27865 nsubjpass resistance,augmented
R14579 T27855 T27854 prep of,resistance
R14580 T27856 T27855 pobj CD4,of
R14581 T27759 T27737 ccomp induced,suggest
R14582 T27857 T27859 nummod +,cells
R14583 T27858 T27859 compound T,cells
R14584 T27859 T27854 conj cells,resistance
R14585 T27760 T27759 prep after,induced
R14586 T27860 T27859 prep to,cells
R14587 T27861 T27860 pobj IL-10,to
R14588 T27862 T27865 aux can,augmented
R14589 T27761 T27762 amod chronic,exposure
R14590 T27863 T27865 auxpass be,augmented
R14591 T27864 T27865 advmod even,augmented
R14592 T27865 T27849 ccomp augmented,is
R14593 T27866 T27865 prep after,augmented
R14594 T27762 T27760 pobj exposure,after
R14595 T27867 T27866 pobj migration,after
R14596 T27868 T27867 prep into,migration
R14597 T27869 T27871 det the,ST
R14598 T27763 T27762 prep in,exposure
R14599 T27870 T27871 amod inflamed,ST
R14600 T27871 T27868 pobj ST,into
R14601 T27872 T27865 punct ",",augmented
R14602 T27764 T27763 pobj vivo,in
R14603 T27873 T27877 mark because,concentrated
R14604 T27765 T27762 prep to,exposure
R14605 T27766 T27767 amod high,concentrations
R14606 T27874 T27877 nsubjpass IL-6,concentrated
R14607 T27875 T27877 auxpass is,concentrated
R14608 T27876 T27877 advmod highly,concentrated
R14609 T27767 T27765 pobj concentrations,to
R14610 T27877 T27865 advcl concentrated,augmented
R14611 T27878 T27877 prep compared,concentrated
R14612 T27768 T27767 prep of,concentrations
R14613 T27879 T27878 prep with,compared
R14614 T27880 T27882 det the,level
R14615 T27881 T27882 compound blood,level
R14616 T27882 T27879 pobj level,with
R14617 T27769 T27770 compound serum,IL-6
R14618 T27883 T27885 nmod [,]
R14619 T27884 T27885 nummod 27,]
R14620 T27885 T27882 appos ],level
R14621 T27770 T27768 pobj IL-6,of
R14622 T27886 T27849 punct .,is
R14623 T27887 T27901 prep In,suggested
R14624 T27888 T27887 pobj addition,In
R14625 T27889 T27901 punct ",",suggested
R14626 T27890 T27891 det the,involvement
R14627 T27891 T27901 nsubjpass involvement,suggested
R14628 T27771 T27737 punct .,suggest
R14629 T27892 T27891 prep of,involvement
R14630 T27893 T27896 amod other,cytokines
R14631 T27894 T27896 amod essential,cytokines
R14632 T27772 T27775 advmod However,is
R14633 T27895 T27896 compound proinflammatory,cytokines
R14634 T27896 T27892 pobj cytokines,of
R14635 T27897 T27896 prep in,cytokines
R14636 T27773 T27775 punct ",",is
R14637 T27898 T27899 det this,process
R14638 T27899 T27897 pobj process,in
R14639 T27900 T27901 auxpass was,suggested
R14640 T27774 T27775 nsubj it,is
R14641 T27901 T27901 ROOT suggested,suggested
R14642 T27902 T27901 agent by,suggested
R14643 T27903 T27905 poss our,experiments
R14644 T27775 T27775 ROOT is,is
R14645 T27904 T27905 amod preliminary,experiments
R14646 T27905 T27902 pobj experiments,by
R14647 T27906 T27905 acl demonstrating,experiments
R14648 T27776 T27775 advmod also,is
R14649 T27907 T27917 mark that,reduced
R14650 T27908 T27910 amod IL-10-mediated,inhibition
R14651 T27909 T27910 amod IFN-γ,inhibition
R14652 T27777 T27775 acomp possible,is
R14653 T27910 T27917 nsubjpass inhibition,reduced
R14654 T27911 T27910 prep in,inhibition
R14655 T27912 T27911 pobj CD4,in
R14656 T27778 T27784 mark that,induced
R14657 T27913 T27915 compound +,cells
R14658 T27914 T27915 compound T,cells
R14659 T27779 T27780 amod STAT3,activity
R14660 T27915 T27910 conj cells,inhibition
R14661 T27916 T27917 auxpass was,reduced
R14662 T27917 T27906 ccomp reduced,demonstrating
R14663 T27780 T27784 nsubjpass activity,induced
R14664 T27781 T27784 aux could,induced
R14665 T27918 T27917 prep by,reduced
R14666 T27782 T27784 auxpass be,induced
R14667 T27919 T27918 pobj pretreatment,by
R14668 T27920 T27917 prep with,reduced
R14669 T27921 T27920 pobj IL-1β,with
R14670 T27783 T27784 advmod constitutively,induced
R14671 T27922 T27921 cc and,IL-1β
R14672 T27923 T27921 conj TNF-α,IL-1β
R14673 T27784 T27775 ccomp induced,is
R14674 T27924 T27917 punct ",",reduced
R14675 T27925 T27934 mark although,shown
R14676 T27926 T27927 advmod less,effectively
R14677 T27927 T27934 advmod effectively,shown
R14678 T27928 T27927 prep than,effectively
R14679 T27785 T27784 prep in,induced
R14680 T27929 T27928 prep by,than
R14681 T27930 T27929 pobj IL-6,by
R14682 T27931 T27934 punct (,shown
R14683 T27786 T27789 nummod CD4,cells
R14684 T27932 T27934 nsubjpass data,shown
R14685 T27933 T27934 neg not,shown
R14686 T27934 T27917 advcl shown,reduced
R14687 T27787 T27789 nummod +,cells
R14688 T27935 T27917 punct ),reduced
R14689 T27936 T27901 punct .,suggested
R14690 T27937 T27942 advmod Furthermore,produced
R14691 T27788 T27789 compound T,cells
R14692 T27938 T27942 punct ",",produced
R14693 T27939 T27942 nsubj IFN-γ,produced
R14694 T27789 T27785 pobj cells,in
R14695 T27940 T27939 cc and,IFN-γ
R14696 T27941 T27939 conj IL-10,IFN-γ
R14697 T27942 T27950 nsubj produced,be
R14698 T27790 T27784 agent by,induced
R14699 T27791 T27794 poss their,secretion
R14700 T27943 T27942 agent by,produced
R14701 T27944 T27947 compound CD4,cells
R14702 T27792 T27794 amod own,secretion
R14703 T27945 T27947 compound +,cells
R14704 T27946 T27947 compound T,cells
R14705 T27793 T27794 compound IL-10,secretion
R14706 T27947 T27943 pobj cells,by
R14707 T27948 T27947 appos themselves,cells
R14708 T27949 T27950 aux could,be
R14709 T27794 T27790 pobj secretion,by
R14710 T27950 T27950 ROOT be,be
R14711 T27951 T27950 acomp responsible,be
R14712 T27952 T27951 prep for,responsible
R14713 T27795 T27784 punct ",",induced
R14714 T27953 T27955 amod impaired,signaling
R14715 T27954 T27955 compound IL-10,signaling
R14716 T27955 T27952 pobj signaling,for
R14717 T27796 T27784 advcl leading,induced
R14718 T27956 T27955 prep in,signaling
R14719 T27957 T27958 det the,ST
R14720 T27958 T27956 pobj ST,in
R14721 T27797 T27796 prep to,leading
R14722 T27959 T27950 punct ",",be
R14723 T27960 T27963 mark because,produce
R14724 T27798 T27799 det the,loss
R14725 T27961 T27962 compound T-cell,infiltrates
R14726 T27962 T27963 nsubj infiltrates,produce
R14727 T27963 T27950 advcl produce,be
R14728 T27964 T27968 det both,]
R14729 T27965 T27968 nmod cytokines,]
R14730 T27966 T27968 nmod [,]
R14731 T27799 T27797 pobj loss,to
R14732 T27967 T27968 nummod "34,35",]
R14733 T27968 T27963 dobj ],produce
R14734 T27800 T27799 prep of,loss
R14735 T27801 T27800 pobj sensitivity,of
R14736 T27969 T27950 punct .,be
R14737 T27970 T27978 prep In,stimulate
R14738 T27802 T27801 prep to,sensitivity
R14739 T27971 T27973 det an,fashion
R14740 T27972 T27973 amod autocrine,fashion
R14741 T27973 T27970 pobj fashion,In
R14742 T27803 T27804 amod exogenous,IL-10
R14743 T27974 T27978 punct ",",stimulate
R14744 T27975 T27978 nsubj IL-10,stimulate
R14745 T27804 T27802 pobj IL-10,to
R14746 T27976 T27978 aux may,stimulate
R14747 T27977 T27978 advmod persistently,stimulate
R14748 T27978 T27978 ROOT stimulate,stimulate
R14749 T27805 T27784 punct ",",induced
R14750 T27979 T27980 amod STAT3,activation
R14751 T27980 T27978 dobj activation,stimulate
R14752 T27981 T27980 cc and,activation
R14753 T27806 T27809 mark because,+
R14754 T27982 T27980 conj IFN-γ,activation
R14755 T27983 T27984 aux can,induce
R14756 T27984 T27978 conj induce,stimulate
R14757 T27807 T27808 compound RA,CD4
R14758 T27985 T27986 nummod SOCS1,protein
R14759 T27986 T27984 dobj protein,induce
R14760 T27987 T27984 prep as,induce
R14761 T27808 T27809 nsubj CD4,+
R14762 T27988 T27990 det a,inhibitor
R14763 T27989 T27990 compound crosstalk,inhibitor
R14764 T27990 T27987 pobj inhibitor,as
R14765 T27809 T27784 advcl +,induced
R14766 T27991 T27990 prep of,inhibitor
R14767 T27992 T27991 pobj IL-10,of
R14768 T27993 T27984 advcl signaling,induce
R14769 T27810 T27811 compound T,cells
R14770 T27994 T27996 nmod [,]
R14771 T27995 T27996 nummod 32,]
R14772 T27996 T27993 dobj ],signaling
R14773 T27811 T27809 dobj cells,+
R14774 T27812 T27809 prep in,+
R14775 T27997 T27978 punct .,stimulate
R14776 T27998 T28000 det The,effect
R14777 T27999 T28000 amod T-cell-inhibitory,effect
R14778 T28000 T28006 nsubjpass effect,modulated
R14779 T28001 T28000 prep of,effect
R14780 T27813 T27814 det the,ST
R14781 T28002 T28001 pobj IL-10,of
R14782 T28003 T28006 aux may,modulated
R14783 T28004 T28006 advmod therefore,modulated
R14784 T27814 T27812 pobj ST,in
R14785 T28005 T28006 auxpass be,modulated
R14786 T28006 T28006 ROOT modulated,modulated
R14787 T27815 T27784 conj are,induced
R14788 T28007 T28006 advmod complicatedly,modulated
R14789 T28008 T28006 prep upon,modulated
R14790 T28009 T28008 pobj exposure,upon
R14791 T27816 T27815 acomp capable,are
R14792 T28010 T28009 prep to,exposure
R14793 T28011 T28013 det an,environment
R14794 T28012 T28013 amod inflammatory,environment
R14795 T27817 T27816 prep of,capable
R14796 T28013 T28010 pobj environment,to
R14797 T28014 T28013 prep in,environment
R14798 T28015 T28016 compound RA,joints
R14799 T27818 T27817 pcomp producing,of
R14800 T28016 T28014 pobj joints,in
R14801 T28017 T28016 punct ",",joints
R14802 T28018 T28021 advmod where,are
R14803 T27819 T27820 amod significant,levels
R14804 T28019 T28020 amod many,cytokines
R14805 T28020 T28021 nsubj cytokines,are
R14806 T27820 T27818 dobj levels,producing
R14807 T28021 T28013 relcl are,environment
R14808 T28022 T28021 acomp present,are
R14809 T28023 T28026 advmod substantially,]
R14810 T27821 T27820 prep of,levels
R14811 T28024 T28026 nmod [,]
R14812 T28025 T28026 nummod 10,]
R14813 T27822 T27823 compound IL-10,[
R14814 T28026 T28013 appos ],environment
R14815 T28027 T28006 punct .,modulated
R14816 T28028 T28029 nummod STAT3,activation
R14817 T28029 T28032 nsubjpass activation,implicated
R14818 T27823 T27821 pobj [,of
R14819 T28030 T28032 aux has,implicated
R14820 T28031 T28032 auxpass been,implicated
R14821 T27824 T27825 nummod 34,]
R14822 T28032 T28032 ROOT implicated,implicated
R14823 T28033 T28032 prep in,implicated
R14824 T28034 T28035 det the,pathogenesis
R14825 T28035 T28033 pobj pathogenesis,in
R14826 T28036 T28035 prep of,pathogenesis
R14827 T28037 T28036 pobj RA,of
R14828 T28038 T28032 punct .,implicated
R14829 T27825 T27815 npadvmod ],are
R14830 T28039 T28040 compound Active,STAT3
R14831 T28040 T28043 nsubjpass STAT3,expressed
R14832 T28041 T28043 auxpass is,expressed
R14833 T27826 T27775 punct .,is
R14834 T28042 T28043 advmod constitutively,expressed
R14835 T28043 T28043 ROOT expressed,expressed
R14836 T27827 T27830 nummod CD4,cells
R14837 T27828 T27830 nummod +,cells
R14838 T27829 T27830 compound T,cells
R14839 T28044 T28043 prep in,expressed
R14840 T28045 T28048 amod synovial,cells
R14841 T27830 T27831 nsubj cells,isolated
R14842 T28046 T28048 amod fluid,cells
R14843 T28047 T28048 compound mononuclear,cells
R14844 T28048 T28044 pobj cells,in
R14845 T27831 T27838 nsubj isolated,showed
R14846 T28049 T28048 prep from,cells
R14847 T28050 T28051 compound RA,patients
R14848 T27832 T27831 prep from,isolated
R14849 T28051 T28049 pobj patients,from
R14850 T28052 T28054 nmod [,]
R14851 T28053 T28054 nummod 36,]
R14852 T27833 T27834 det the,ST
R14853 T28054 T28048 appos ],cells
R14854 T28055 T28043 punct .,expressed
R14855 T27834 T27832 pobj ST,from
R14856 T28056 T28057 nsubj IL-6,is
R14857 T28057 T28057 ROOT is,is
R14858 T28058 T28062 det the,present
R14859 T28059 T28062 amod major,present
R14860 T27835 T27834 prep of,ST
R14861 T28060 T28061 amod STAT3-activating,factor
R14862 T28061 T28062 compound factor,present
R14863 T28062 T28057 attr present,is
R14864 T28063 T28062 prep in,present
R14865 T27836 T27835 pobj RA,of
R14866 T28064 T28065 amod synovial,fluid
R14867 T28065 T28063 pobj fluid,in
R14868 T27837 T27838 advmod also,showed
R14869 T28066 T28065 punct ",",fluid
R14870 T28067 T28068 nsubj which,has
R14871 T28068 T28062 relcl has,present
R14872 T28069 T28071 det a,role
R14873 T27838 T27838 ROOT showed,showed
R14874 T28070 T28071 amod crucial,role
R14875 T28071 T28068 dobj role,has
R14876 T28072 T28071 prep in,role
R14877 T28073 T28074 det the,activation
R14878 T28074 T28072 pobj activation,in
R14879 T28075 T28074 prep of,activation
R14880 T28141 T28139 appos ],[
R14881 T28076 T28077 compound monocyte,functions
R14882 T28142 T28108 punct .,thought
R14883 T28077 T28075 pobj functions,of
R14884 T28078 T28079 amod such,as
R14885 T28079 T28077 prep as,functions
R14886 T28143 T28148 prep In,is
R14887 T28080 T28081 compound gene,expression
R14888 T28081 T28079 pobj expression,as
R14889 T28082 T28081 prep of,expression
R14890 T28144 T28145 det this,regard
R14891 T28083 T28087 det the,type
R14892 T28084 T28087 compound Fc,type
R14893 T28085 T28086 compound gamma,receptor
R14894 T28145 T28143 pobj regard,In
R14895 T28086 T28087 compound receptor,type
R14896 T28087 T28082 pobj type,of
R14897 T28146 T28148 punct ",",is
R14898 T28088 T28081 conj I,expression
R14899 T28089 T28088 cc and,I
R14900 T28090 T28091 compound type,III
R14901 T28147 T28148 nsubj STAT3,is
R14902 T28091 T28088 conj III,I
R14903 T28092 T28088 cc and,I
R14904 T28093 T28081 prep of,expression
R14905 T28148 T28148 ROOT is,is
R14906 T28094 T28095 compound HLA-DR,[
R14907 T28095 T28093 pobj [,of
R14908 T28096 T28097 nummod 31,]
R14909 T28149 T28148 acomp critical,is
R14910 T28097 T28095 appos ],[
R14911 T28098 T28057 punct .,is
R14912 T28099 T28100 advmod More,recently
R14913 T28150 T28149 prep in,critical
R14914 T28100 T28108 advmod recently,thought
R14915 T28101 T28108 punct ",",thought
R14916 T28151 T28152 det the,survival
R14917 T28102 T28103 amod high,levels
R14918 T28103 T28108 nsubj levels,thought
R14919 T28104 T28103 prep of,levels
R14920 T28105 T28106 amod activated,STAT3
R14921 T28152 T28159 nmod survival,fibroblasts
R14922 T28106 T28104 pobj STAT3,of
R14923 T28107 T28108 punct ",",thought
R14924 T28108 T28108 ROOT thought,thought
R14925 T28109 T28111 aux to,induced
R14926 T28110 T28111 auxpass be,induced
R14927 T28111 T28108 xcomp induced,thought
R14928 T28153 T28152 cc and,survival
R14929 T28112 T28111 advmod mainly,induced
R14930 T28113 T28111 agent by,induced
R14931 T28114 T28113 pobj IL-6,by
R14932 T28154 T28152 conj expansion,survival
R14933 T28115 T28108 punct ",",thought
R14934 T28116 T28118 aux have,detected
R14935 T28117 T28118 auxpass been,detected
R14936 T28118 T28108 ccomp detected,thought
R14937 T28119 T28118 prep in,detected
R14938 T28155 T28154 prep of,expansion
R14939 T28120 T28121 det the,ST
R14940 T28121 T28119 pobj ST,in
R14941 T28122 T28118 punct ",",detected
R14942 T28123 T28118 cc and,detected
R14943 T28156 T28155 pobj growth,of
R14944 T28124 T28125 compound STAT3,activation
R14945 T28125 T28128 nsubjpass activation,shown
R14946 T28126 T28128 aux has,shown
R14947 T28157 T28159 nmod factor-dependent,fibroblasts
R14948 T28127 T28128 auxpass been,shown
R14949 T28128 T28118 conj shown,detected
R14950 T28129 T28131 aux to,involved
R14951 T28158 T28159 amod synovial,fibroblasts
R14952 T28130 T28131 auxpass be,involved
R14953 T28131 T28128 xcomp involved,shown
R14954 T28159 T28150 pobj fibroblasts,in
R14955 T28132 T28131 prep in,involved
R14956 T28133 T28135 amod synovial,proliferation
R14957 T28134 T28135 compound fibroblast,proliferation
R14958 T28160 T28162 nmod [,]
R14959 T28135 T28132 pobj proliferation,in
R14960 T28136 T28135 cc and,proliferation
R14961 T28137 T28138 compound IL-6,production
R14962 T28161 T28162 nummod 38,]
R14963 T28138 T28139 compound production,[
R14964 T28139 T28131 dobj [,involved
R14965 T28140 T28141 nummod 37,]
R14966 T28245 T28240 prep through,resistant
R14967 T28246 T28248 amod gp130-mediated,activation
R14968 T28247 T28248 nummod STAT3,activation
R14969 T28162 T28159 appos ],fibroblasts
R14970 T28163 T28148 punct .,is
R14971 T28248 T28245 pobj activation,through
R14972 T28164 T28178 advmod Furthermore,suggested
R14973 T28165 T28178 punct ",",suggested
R14974 T28249 T28238 punct .,activated
R14975 T28166 T28167 det the,significance
R14976 T28167 T28178 nsubjpass significance,suggested
R14977 T28168 T28167 prep of,significance
R14978 T28169 T28171 amod persistent,signaling
R14979 T28170 T28171 nummod STAT3,signaling
R14980 T28171 T28168 pobj signaling,of
R14981 T28172 T28171 prep in,signaling
R14982 T28250 T28251 det The,longevity
R14983 T28173 T28175 amod Th1-cell-dominated,arthritis
R14984 T28174 T28175 amod autoimmune,arthritis
R14985 T28175 T28172 pobj arthritis,in
R14986 T28176 T28178 aux has,suggested
R14987 T28251 T28262 nsubjpass longevity,regulated
R14988 T28177 T28178 auxpass been,suggested
R14989 T28178 T28178 ROOT suggested,suggested
R14990 T28252 T28251 prep of,longevity
R14991 T28179 T28178 agent by,suggested
R14992 T28180 T28179 pobj studies,by
R14993 T28181 T28180 prep of,studies
R14994 T28253 T28254 compound cytokine,signals
R14995 T28182 T28184 det the,mice
R14996 T28183 T28184 compound gp130F759/F759,mice
R14997 T28184 T28181 pobj mice,of
R14998 T28254 T28252 pobj signals,of
R14999 T28185 T28180 punct ",",studies
R15000 T28186 T28214 prep in,mutated
R15001 T28255 T28251 acl transduced,longevity
R15002 T28187 T28186 pobj which,in
R15003 T28188 T28193 det the,site
R15004 T28189 T28193 nmod Src,site
R15005 T28256 T28255 agent by,transduced
R15006 T28190 T28193 nmod homology,site
R15007 T28191 T28193 amod phosphatase-2,site
R15008 T28192 T28193 amod binding,site
R15009 T28257 T28258 det the,JAK
R15010 T28193 T28214 nsubjpass site,mutated
R15011 T28194 T28193 prep of,site
R15012 T28195 T28194 pobj gp130,of
R15013 T28258 T28256 pobj JAK,by
R15014 T28196 T28195 punct (,gp130
R15015 T28197 T28201 det the,subunit
R15016 T28198 T28201 nmod transmembrane,subunit
R15017 T28259 T28260 compound STAT,pathway
R15018 T28199 T28201 nmod glycoprotein,subunit
R15019 T28260 T28262 nsubjpass pathway,regulated
R15020 T28261 T28262 auxpass is,regulated
R15021 T28200 T28201 compound β,subunit
R15022 T28201 T28195 appos subunit,gp130
R15023 T28202 T28201 prep of,subunit
R15024 T28262 T28262 ROOT regulated,regulated
R15025 T28203 T28207 det the,receptor
R15026 T28204 T28205 compound IL-6,family
R15027 T28205 T28207 nmod family,receptor
R15028 T28206 T28207 compound cytokine,receptor
R15029 T28207 T28202 pobj receptor,of
R15030 T28263 T28262 agent by,regulated
R15031 T28208 T28195 punct ),gp130
R15032 T28209 T28193 punct ",",site
R15033 T28210 T28211 amod tyrosine,759
R15034 T28264 T28267 det the,proteins
R15035 T28211 T28193 appos 759,site
R15036 T28212 T28214 punct ",",mutated
R15037 T28213 T28214 auxpass was,mutated
R15038 T28214 T28180 relcl mutated,studies
R15039 T28265 T28266 compound SOCS,family
R15040 T28215 T28216 aux to,phenylalanine
R15041 T28216 T28214 advcl phenylalanine,mutated
R15042 T28266 T28267 compound family,proteins
R15043 T28217 T28216 dobj [,phenylalanine
R15044 T28218 T28219 nummod 39,]
R15045 T28219 T28217 appos ],[
R15046 T28267 T28263 pobj proteins,by
R15047 T28220 T28178 punct .,suggested
R15048 T28221 T28238 prep In,activated
R15049 T28222 T28224 det the,mice
R15050 T28268 T28270 nmod [,]
R15051 T28223 T28224 compound gp130F759/F759,mice
R15052 T28224 T28221 pobj mice,In
R15053 T28225 T28238 punct ",",activated
R15054 T28269 T28270 nummod 7,]
R15055 T28226 T28227 compound T,cells
R15056 T28227 T28238 nsubjpass cells,activated
R15057 T28228 T28227 punct ",",cells
R15058 T28270 T28262 npadvmod ],regulated
R15059 T28229 T28234 advmod particularly,subset
R15060 T28230 T28234 det the,subset
R15061 T28231 T28234 compound CD4,subset
R15062 T28271 T28262 punct .,regulated
R15063 T28232 T28234 compound +,subset
R15064 T28272 T28273 nsubj We,found
R15065 T28233 T28234 compound T-cell,subset
R15066 T28234 T28227 appos subset,cells
R15067 T28273 T28273 ROOT found,found
R15068 T28235 T28238 punct ",",activated
R15069 T28236 T28238 auxpass are,activated
R15070 T28274 T28284 mark that,expressed
R15071 T28237 T28238 advmod chronically,activated
R15072 T28238 T28238 ROOT activated,activated
R15073 T28239 T28238 cc and,activated
R15074 T28275 T28278 nummod CD4,cells
R15075 T28240 T28238 conj resistant,activated
R15076 T28241 T28244 nmod to,death
R15077 T28242 T28244 amod activation-induced,death
R15078 T28243 T28244 compound cell,death
R15079 T28244 T28240 dobj death,resistant
R15080 T28276 T28278 nummod +,cells
R15081 T28277 T28278 compound T,cells
R15082 T28278 T28284 nsubj cells,expressed
R15083 T28279 T28278 prep from,cells
R15084 T28342 T28343 auxpass are,induced
R15085 T28280 T28279 pobj patients,from
R15086 T28343 T28343 ROOT induced,induced
R15087 T28344 T28343 agent by,induced
R15088 T28345 T28346 amod various,cytokines
R15089 T28281 T28280 prep with,patients
R15090 T28346 T28344 pobj cytokines,by
R15091 T28347 T28346 punct ",",cytokines
R15092 T28348 T28346 prep including,cytokines
R15093 T28282 T28283 amod active,RA
R15094 T28349 T28348 pobj IL-6,including
R15095 T28350 T28349 cc and,IL-6
R15096 T28351 T28349 conj IL-10,IL-6
R15097 T28283 T28281 pobj RA,with
R15098 T28352 T28343 punct ",",induced
R15099 T28353 T28343 prep as,induced
R15100 T28354 T28353 pobj mediators,as
R15101 T28355 T28354 prep of,mediators
R15102 T28284 T28273 ccomp expressed,found
R15103 T28356 T28357 amod negative,feedback
R15104 T28357 T28355 pobj feedback,of
R15105 T28358 T28357 cc and,feedback
R15106 T28285 T28286 amod higher,levels
R15107 T28359 T28360 compound crosstalk,inhibition
R15108 T28360 T28361 compound inhibition,[
R15109 T28361 T28354 appos [,mediators
R15110 T28286 T28284 dobj levels,expressed
R15111 T28362 T28361 nummod 7,[
R15112 T28363 T28361 appos ],[
R15113 T28364 T28343 punct .,induced
R15114 T28287 T28286 prep of,levels
R15115 T28365 T28366 amod Recent,studies
R15116 T28366 T28373 nsubj studies,revealed
R15117 T28367 T28366 prep with,studies
R15118 T28288 T28287 pobj SOCS1,of
R15119 T28368 T28367 pobj mice,with
R15120 T28369 T28366 acl lacking,studies
R15121 T28370 T28369 dobj SOCS3,lacking
R15122 T28289 T28284 punct ",",expressed
R15123 T28371 T28370 cc or,SOCS3
R15124 T28372 T28370 conj SOCS1,SOCS3
R15125 T28373 T28373 ROOT revealed,revealed
R15126 T28374 T28376 mark that,is
R15127 T28375 T28376 nsubj SOCS3,is
R15128 T28290 T28284 cc but,expressed
R15129 T28376 T28373 ccomp is,revealed
R15130 T28377 T28379 det a,regulator
R15131 T28378 T28379 amod negative,regulator
R15132 T28291 T28292 amod lower,levels
R15133 T28379 T28376 attr regulator,is
R15134 T28380 T28379 prep of,regulator
R15135 T28381 T28380 pobj IL-6,of
R15136 T28292 T28296 nsubj levels,compared
R15137 T28382 T28380 pcomp signaling,of
R15138 T28383 T28385 cc but,of
R15139 T28384 T28385 neg not,of
R15140 T28293 T28292 prep of,levels
R15141 T28385 T28382 prep of,signaling
R15142 T28386 T28385 pobj IL-10,of
R15143 T28294 T28293 pobj SOCS3,of
R15144 T28387 T28382 conj signaling,signaling
R15145 T28295 T28296 punct ",",compared
R15146 T28388 T28373 punct .,revealed
R15147 T28389 T28395 nsubj Studies,shown
R15148 T28296 T28284 conj compared,expressed
R15149 T28390 T28389 prep of,Studies
R15150 T28391 T28393 amod conditional,mice
R15151 T28392 T28393 amod SOCS3-deficient,mice
R15152 T28393 T28390 pobj mice,of
R15153 T28297 T28296 prep with,compared
R15154 T28394 T28395 aux have,shown
R15155 T28395 T28395 ROOT shown,shown
R15156 T28396 T28398 det that,deficiency
R15157 T28298 T28302 amod normal,cells
R15158 T28397 T28398 nummod SOCS3,deficiency
R15159 T28398 T28395 dobj deficiency,shown
R15160 T28299 T28302 compound CD4,cells
R15161 T28399 T28398 punct ",",deficiency
R15162 T28400 T28398 cc but,deficiency
R15163 T28401 T28403 neg not,deficiency
R15164 T28300 T28302 nummod +,cells
R15165 T28402 T28403 nummod SOCS1,deficiency
R15166 T28403 T28398 conj deficiency,deficiency
R15167 T28404 T28403 punct ",",deficiency
R15168 T28301 T28302 compound T,cells
R15169 T28405 T28398 conj results,deficiency
R15170 T28406 T28405 prep in,results
R15171 T28407 T28408 amod sustained,activation
R15172 T28302 T28297 pobj cells,with
R15173 T28408 T28406 pobj activation,in
R15174 T28409 T28408 prep of,activation
R15175 T28410 T28409 pobj STAT3,of
R15176 T28411 T28398 prep in,deficiency
R15177 T28412 T28411 pobj response,in
R15178 T28413 T28412 prep to,response
R15179 T28303 T28273 punct .,found
R15180 T28414 T28417 compound IL-6,]
R15181 T28415 T28417 compound [,]
R15182 T28416 T28417 compound "8,41",]
R15183 T28417 T28413 pobj ],to
R15184 T28304 T28305 nsubj SOCS1,prevents
R15185 T28418 T28395 punct .,shown
R15186 T28419 T28420 det The,analysis
R15187 T28305 T28305 ROOT prevents,prevents
R15188 T28420 T28425 nsubj analysis,indicated
R15189 T28421 T28420 prep of,analysis
R15190 T28422 T28423 amod SOCS3-deficient,macrophages
R15191 T28423 T28421 pobj macrophages,of
R15192 T28306 T28305 dobj activation,prevents
R15193 T28424 T28425 aux has,indicated
R15194 T28425 T28425 ROOT indicated,indicated
R15195 T28307 T28306 prep of,activation
R15196 T28426 T28428 mark that,is
R15197 T28427 T28428 nsubj SOCS3,is
R15198 T28428 T28425 ccomp is,indicated
R15199 T28308 T28307 pobj JAK,of
R15200 T28429 T28431 det a,inhibitor
R15201 T28430 T28431 amod crucial,inhibitor
R15202 T28431 T28428 attr inhibitor,is
R15203 T28309 T28305 prep by,prevents
R15204 T28432 T28431 prep of,inhibitor
R15205 T28433 T28436 det the,response
R15206 T28434 T28436 amod IL-6-induced,response
R15207 T28310 T28311 advmod directly,binding
R15208 T28435 T28436 amod transcriptional,response
R15209 T28436 T28432 pobj response,of
R15210 T28437 T28439 nmod [,]
R15211 T28438 T28439 nummod 42,]
R15212 T28311 T28309 pcomp binding,by
R15213 T28312 T28311 prep to,binding
R15214 T28313 T28312 pobj JAK,to
R15215 T28439 T28436 appos ],response
R15216 T28440 T28425 punct .,indicated
R15217 T28314 T28305 punct ",",prevents
R15218 T28441 T28444 advmod However,is
R15219 T28442 T28444 punct ",",is
R15220 T28315 T28305 cc and,prevents
R15221 T28443 T28444 nsubj SOCS3,is
R15222 T28444 T28444 ROOT is,is
R15223 T28445 T28444 acomp dispensable,is
R15224 T28316 T28317 nsubj SOCS3,inhibits
R15225 T28446 T28445 prep for,dispensable
R15226 T28447 T28451 preconj both,inhibition
R15227 T28448 T28451 det the,inhibition
R15228 T28449 T28451 amod negative,inhibition
R15229 T28450 T28451 compound feedback,inhibition
R15230 T28451 T28446 pobj inhibition,for
R15231 T28452 T28451 cc and,inhibition
R15232 T28317 T28305 conj inhibits,prevents
R15233 T28453 T28455 det the,action
R15234 T28454 T28455 amod immunoregulatory,action
R15235 T28455 T28451 conj action,inhibition
R15236 T28318 T28319 det the,action
R15237 T28456 T28455 prep of,action
R15238 T28457 T28456 pobj IL-10,of
R15239 T28319 T28317 dobj action,inhibits
R15240 T28458 T28455 prep in,action
R15241 T28459 T28458 pobj macrophages,in
R15242 T28460 T28462 nmod [,]
R15243 T28320 T28319 prep of,action
R15244 T28461 T28462 nummod 41,]
R15245 T28462 T28455 appos ],action
R15246 T28463 T28444 punct .,is
R15247 T28321 T28320 pobj JAK,of
R15248 T28464 T28470 prep On,found
R15249 T28465 T28466 det the,contrary
R15250 T28466 T28464 pobj contrary,On
R15251 T28322 T28319 prep by,action
R15252 T28323 T28322 pcomp binding,by
R15253 T28467 T28470 punct ",",found
R15254 T28468 T28470 nsubjpass SOCS1,found
R15255 T28324 T28323 prep to,binding
R15256 T28469 T28470 auxpass was,found
R15257 T28470 T28470 ROOT found,found
R15258 T28325 T28329 det the,domain
R15259 T28471 T28473 aux to,inhibit
R15260 T28472 T28473 advmod directly,inhibit
R15261 T28473 T28470 advcl inhibit,found
R15262 T28326 T28329 nmod Src,domain
R15263 T28474 T28475 npadvmod IL-10-mediated,signaling
R15264 T28475 T28478 amod signaling,]
R15265 T28327 T28329 nmod homology,domain
R15266 T28476 T28478 nmod [,]
R15267 T28477 T28478 nummod 43,]
R15268 T28328 T28329 amod phosphatase-2-binding,domain
R15269 T28478 T28473 dobj ],inhibit
R15270 T28479 T28470 punct .,found
R15271 T28480 T28482 amod Increased,expression
R15272 T28329 T28324 pobj domain,to
R15273 T28481 T28482 nummod SOCS1,expression
R15274 T28482 T28492 nsubjpass expression,associated
R15275 T28483 T28482 prep in,expression
R15276 T28484 T28485 compound RA,CD4
R15277 T28485 T28483 pobj CD4,in
R15278 T28486 T28488 amod +,cells
R15279 T28330 T28329 prep of,domain
R15280 T28487 T28488 compound T,cells
R15281 T28488 T28492 nsubjpass cells,associated
R15282 T28489 T28492 aux may,associated
R15283 T28490 T28492 advmod therefore,associated
R15284 T28331 T28330 pobj receptors,of
R15285 T28491 T28492 auxpass be,associated
R15286 T28492 T28511 csubj associated,be
R15287 T28332 T28333 amod such,as
R15288 T28493 T28492 prep with,associated
R15289 T28494 T28497 preconj both,responsiveness
R15290 T28495 T28497 det the,responsiveness
R15291 T28333 T28331 prep as,receptors
R15292 T28496 T28497 amod impaired,responsiveness
R15293 T28497 T28493 pobj responsiveness,with
R15294 T28498 T28497 prep to,responsiveness
R15295 T28334 T28337 nummod gp130,]
R15296 T28499 T28498 pobj IL-10,to
R15297 T28500 T28498 cc and,to
R15298 T28335 T28337 nmod [,]
R15299 T28501 T28498 conj to,to
R15300 T28502 T28504 amod IL-10-mediated,activation
R15301 T28503 T28504 nummod STAT3,activation
R15302 T28504 T28501 pobj activation,to
R15303 T28336 T28337 nummod 40,]
R15304 T28505 T28497 punct ",",responsiveness
R15305 T28506 T28497 cc and,responsiveness
R15306 T28507 T28509 amod defective,expression
R15307 T28337 T28333 pobj ],as
R15308 T28508 T28509 nummod SOCS3,expression
R15309 T28509 T28497 conj expression,responsiveness
R15310 T28338 T28317 punct .,inhibits
R15311 T28510 T28511 aux may,be
R15312 T28511 T28511 ROOT be,be
R15313 T28512 T28511 acomp responsible,be
R15314 T28339 T28343 nsubjpass SOCS1,induced
R15315 T28513 T28512 prep for,responsible
R15316 T28514 T28516 amod persistent,activation
R15317 T28515 T28516 nummod STAT3,activation
R15318 T28340 T28339 cc and,SOCS1
R15319 T28516 T28513 pobj activation,for
R15320 T28517 T28516 prep in,activation
R15321 T28518 T28517 pobj response,in
R15322 T28341 T28339 conj SOCS3,SOCS1
R15323 T28519 T28520 aux to,serum
R15324 T28520 T28516 relcl serum,activation
R15325 T28521 T28520 dobj IL-6,serum
R15326 T28522 T28511 punct .,be
R15327 T28523 T28524 expl There,is
R15328 T28536 T28535 prep of,ability
R15329 T28524 T28524 ROOT is,is
R15330 T28525 T28526 det a,possibility
R15331 T28526 T28524 attr possibility,is
R15332 T28537 T28540 nummod CD4,cells
R15333 T28527 T28532 mark that,associated
R15334 T28528 T28529 compound SOCS1,induction
R15335 T28538 T28540 nummod +,cells
R15336 T28529 T28532 nsubjpass induction,associated
R15337 T28530 T28532 aux may,associated
R15338 T28531 T28532 auxpass be,associated
R15339 T28539 T28540 compound T,cells
R15340 T28532 T28526 acl associated,possibility
R15341 T28533 T28532 prep with,associated
R15342 T28534 T28535 det the,ability
R15343 T28535 T28533 pobj ability,with
R15344 T28540 T28536 pobj cells,of
R15345 T28541 T28542 aux to,produce
R15346 T28542 T28535 acl produce,ability
R15347 T28543 T28542 dobj IFN-γ,produce
R15348 T28544 T28532 punct ",",associated
R15349 T28545 T28554 mark because,produce
R15350 T28546 T28549 compound CD4,cells
R15352 T28547 T28549 compound +,cells
R15356 T28548 T28549 compound T,cells
R15357 T28549 T28554 nsubj cells,produce
R15360 T28550 T28549 prep from,cells
R15362 T28551 T28552 amod active,RA
R15365 T28552 T28550 pobj RA,from
R15367 T28553 T28554 aux could,produce
R15369 T28554 T28532 advcl produce,associated
R15374 T28655 T28656 amod high,levels
R15381 T28656 T28554 dobj levels,produce
R15382 T28657 T28656 prep of,levels
R15384 T28658 T28657 pobj IFN-γ,of
R15388 T28659 T28554 prep in,produce
R15391 T28660 T28661 det the,presence
R15394 T28661 T28659 pobj presence,in
R15396 T28662 T28661 prep of,presence
R15401 T28663 T28662 pobj IL-10,of
R15403 T28664 T28532 punct ",",associated
R15542 T28893 T28532 cc and,associated
R15546 T28894 T28898 mark because,known
R15548 T28895 T28898 nsubjpass IFN-γ,known
R15550 T28896 T28898 aux has,known
R15551 T28897 T28898 auxpass been,known
R15552 T28898 T28524 advcl known,is
R15554 T28899 T28898 prep as,known
R15555 T28900 T28902 det a,inducer
R15556 T28901 T28902 amod potent,inducer
R15558 T28902 T28899 pobj inducer,as
R15559 T28903 T28902 prep of,inducer
R15560 T28904 T28907 nummod SOCS1,]
R15561 T28914 T29178 det this,regard
R15562 T28905 T28907 nmod [,]
R15563 T28906 T28907 nummod 32,]
R15564 T28907 T28903 pobj ],of
R15565 T28908 T28524 punct .,is
R15566 T28909 T28910 nsubj It,is
R15568 T28910 T28910 ROOT is,is
R15569 T28911 T28910 prep of,is
R15570 T28912 T28911 pobj interest,of
R15571 T28913 T28912 prep in,interest
R15628 T29178 T28913 pobj regard,in
R15629 T29179 T29180 aux to,indicate
R15630 T29180 T28910 xcomp indicate,is
R15631 T29181 T29187 mark that,express
R15633 T29182 T29183 amod polarized,Th1
R15636 T29183 T29186 nmod Th1,cells
R15637 T29184 T29183 cc and,Th1
R15638 T29185 T29183 conj Th2,Th1
R15639 T29186 T29187 nsubj cells,express
R15642 T29187 T29180 ccomp express,indicate
R15643 T29188 T29189 amod high,levels
R15644 T29189 T29187 dobj levels,express
R15646 T29190 T29189 prep of,levels
R15647 T29191 T29190 pobj SOCS1,of
R15649 T29192 T29191 cc and,SOCS1
R15651 T29193 T29194 nummod SOCS3,mRNA
R15653 T29194 T29191 conj mRNA,SOCS1
R15655 T29195 T29194 punct ",",mRNA
R15657 T29196 T29197 advmod respectively,[
R15658 T29197 T29194 appos [,mRNA
R15659 T29198 T29199 nummod 44,]
R15661 T29199 T29194 conj ],mRNA
R15662 T29200 T28910 punct .,is
R15665 T29201 T29203 amod IL-12-induced,activation
R15667 T29202 T29203 nummod STAT4,activation
R15671 T29203 T29205 nsubjpass activation,inhibited
R15674 T29204 T29205 auxpass is,inhibited
R15675 T29205 T29205 ROOT inhibited,inhibited
R15676 T29206 T29205 agent by,inhibited
R15677 T29207 T29208 nummod SOCS3,induction
R15678 T29208 T29206 pobj induction,by
R15679 T29209 T29208 prep in,induction
R15680 T29210 T29211 amod Th2,cells
R15681 T29233 T29231 dobj roles,have
R15682 T29211 T29209 pobj cells,in
R15683 T29234 T29233 prep as,roles
R15684 T29235 T29234 pcomp Th1-specific,as
R15685 T29236 T29235 cc and,Th1-specific
R15686 T29237 T29235 conj Th2-specific,Th1-specific
R15687 T29238 T29243 punct ",",repressors
R15688 T29212 T29205 punct ",",inhibited
R15689 T29239 T29240 advmod mutually,exclusive
R15690 T29240 T29243 amod exclusive,repressors
R15691 T29241 T29243 punct ",",repressors
R15692 T29213 T29218 mark whereas,diminished
R15693 T29242 T29243 amod cross-talk,repressors
R15694 T29243 T29235 conj repressors,Th1-specific
R15695 T29214 T29215 compound IL-4-induced,STAT6
R15696 T29244 T29243 prep of,repressors
R15697 T29245 T29246 det the,IL-4
R15698 T29246 T29244 pobj IL-4,of
R15699 T29215 T29218 nsubjpass STAT6,diminished
R15700 T29247 T29243 appos STAT6,repressors
R15701 T29248 T29247 cc and,STAT6
R15702 T29249 T29250 det the,IL-12
R15703 T29216 T29218 nsubjpass signaling,diminished
R15704 T29250 T29247 conj IL-12,STAT6
R15705 T29251 T29253 nummod STAT4,pathways
R15706 T29252 T29253 compound signaling,pathways
R15707 T29253 T29243 appos pathways,repressors
R15708 T29217 T29218 auxpass is,diminished
R15709 T29254 T29253 punct ",",pathways
R15710 T29255 T29253 advmod respectively,pathways
R15711 T29256 T29243 punct .,repressors
R15712 T29257 T29271 advcl Consistent,express
R15713 T29218 T29205 advcl diminished,inhibited
R15714 T29258 T29257 prep with,Consistent
R15715 T29259 T29260 det this,notion
R15716 T29219 T29218 agent by,diminished
R15717 T29260 T29258 pobj notion,with
R15718 T29261 T29271 punct ",",express
R15719 T29262 T29264 compound PB,cells
R15720 T29220 T29221 nummod SOCS1,induction
R15721 T29263 T29264 compound T,cells
R15722 T29264 T29271 nsubj cells,express
R15723 T29265 T29264 prep from,cells
R15724 T29221 T29219 pobj induction,by
R15725 T29266 T29265 pobj patients,from
R15726 T29267 T29264 prep with,cells
R15727 T29222 T29221 prep in,induction
R15728 T29268 T29269 amod allergic,diseases
R15729 T29269 T29267 pobj diseases,with
R15730 T29270 T29271 advmod significantly,express
R15731 T29223 T29224 amod Th1,cells
R15732 T29271 T29271 ROOT express,express
R15733 T29272 T29273 amod high,levels
R15734 T29273 T29271 dobj levels,express
R15735 T29274 T29273 prep of,levels
R15736 T29275 T29276 nummod SOCS3,transcripts
R15737 T29276 T29274 pobj transcripts,of
R15738 T29224 T29222 pobj cells,in
R15739 T29277 T29271 punct ",",express
R15740 T29278 T29271 cc and,express
R15741 T29279 T29281 det the,expression
R15742 T29225 T29205 punct .,inhibited
R15743 T29280 T29281 compound SOCS3,expression
R15744 T29281 T29282 nsubj expression,correlates
R15745 T29282 T29271 conj correlates,express
R15746 T29226 T29231 nsubj SOCS1,have
R15747 T29283 T29282 advmod well,correlates
R15748 T29284 T29282 prep with,correlates
R15749 T29285 T29287 compound serum,levels
R15750 T29227 T29226 cc and,SOCS1
R15751 T29286 T29287 compound IgE,levels
R15752 T29287 T29284 pobj levels,with
R15753 T29288 T29287 cc and,levels
R15754 T29228 T29226 conj SOCS3,SOCS1
R15755 T29289 T29290 compound disease,pathology
R15756 T29290 T29287 conj pathology,levels
R15757 T29291 T29293 nmod [,]
R15758 T29229 T29231 aux may,have
R15759 T29292 T29293 nummod 45,]
R15760 T29293 T29290 appos ],pathology
R15761 T29230 T29231 advmod thus,have
R15762 T29294 T29282 punct .,correlates
R15763 T29231 T29231 ROOT have,have
R15764 T29295 T29297 amod Higher,expression
R15765 T29296 T29297 nummod SOCS1,expression
R15766 T29232 T29233 amod important,roles
R15767 T29297 T29317 dep expression,is
R15768 T29298 T29297 prep with,expression
R15770 T29299 T29301 amod lower,expression
R15771 T29300 T29301 amod SOCS3,expression
R15772 T29301 T29298 pobj expression,with
R15773 T29302 T29301 prep in,expression
R15774 T29303 T29304 compound PB,CD4
R15775 T29304 T29302 pobj CD4,in
R15776 T29305 T29307 amod +,cells
R15778 T29306 T29307 compound T,cells
R15779 T29307 T29297 conj cells,expression
R15780 T29308 T29307 prep from,cells
R15782 T29309 T29310 compound RA,patients
R15783 T29310 T29308 pobj patients,from
R15784 T29311 T29297 punct ",",expression
R15785 T29312 T29297 prep compared,expression
R15786 T29313 T29312 prep with,compared
R15787 T29314 T29315 amod healthy,controls
R15789 T29315 T29313 pobj controls,with
R15790 T29316 T29317 punct ",",is
R15791 T29317 T29317 ROOT is,is
R15792 T29318 T29317 advmod therefore,is
R15794 T29319 T29320 advmod probably,consistent
R15795 T29320 T29317 acomp consistent,is
R15796 T29321 T29320 prep with,consistent
R15797 T29322 T29324 poss their,bias
R15798 T29323 T29324 amod systemic,bias
R15799 T29324 T29321 pobj bias,with
R15800 T29325 T29324 prep towards,bias
R15801 T29326 T29328 det a,phenotype
R15802 T29327 T29328 amod Th1,phenotype
R15803 T29328 T29325 pobj phenotype,towards
R15805 T29329 T29317 punct ",",is
R15806 T29330 T29334 mark as,demonstrated
R15807 T29331 T29334 aux has,demonstrated
R15808 T29332 T29334 advmod previously,demonstrated
R15810 T29333 T29334 auxpass been,demonstrated
R15811 T29334 T29317 advcl demonstrated,is
R15812 T29335 T29337 compound [,]
R15814 T29336 T29337 compound 46-49,]
R15815 T29337 T29334 dobj ],demonstrated
R15816 T29338 T29317 punct .,is
R16441 T31256 T31259 nummod CD4,cells
R16442 T31257 T31259 nummod +,cells
R16443 T31258 T31259 compound T,cells
R16444 T31259 T31265 nsubjpass cells,characterized
R16445 T31260 T31259 prep from,cells
R16446 T31261 T31263 amod active,patients
R16447 T31262 T31263 compound RA,patients
R16448 T31263 T31260 pobj patients,from
R16449 T31264 T31265 auxpass are,characterized
R16450 T31265 T31265 ROOT characterized,characterized
R16451 T31266 T31265 agent by,characterized
R16452 T31267 T31268 poss their,resistance
R16453 T31268 T31266 pobj resistance,by
R16454 T31269 T31268 prep to,resistance
R16455 T31270 T31271 compound IL-10,inhibition
R16456 T31271 T31269 pobj inhibition,to
R16457 T31272 T31271 prep of,inhibition
R16458 T31273 T31274 compound IFN-γ,production
R16459 T31274 T31272 pobj production,of
R16460 T31275 T31265 punct ",",characterized
R16461 T31276 T31265 conj due,characterized
R16462 T31277 T31278 aux to,constitutive
R16463 T31278 T31276 xcomp constitutive,due
R16464 T31279 T31280 nummod STAT3,phosphorylation
R16465 T31280 T31278 dobj phosphorylation,constitutive
R16466 T31281 T31278 cc and,constitutive
R16467 T31282 T31285 amod impaired,activation
R16468 T31283 T31285 amod IL-10-mediated,activation
R16469 T31284 T31283 nummod STAT3,IL-10-mediated
R16470 T31285 T31276 pobj activation,due
R16471 T31286 T31265 punct .,characterized
R16472 T31287 T31290 det The,signaling
R16473 T31288 T31290 amod defective,signaling
R16474 T31289 T31290 nummod STAT3,signaling
R16475 T31290 T31293 nsubjpass signaling,associated
R16476 T31291 T31293 auxpass is,associated
R16477 T31292 T31293 advmod possibly,associated
R16478 T31293 T31293 ROOT associated,associated
R16479 T31294 T31293 prep with,associated
R16480 T31295 T31296 nummod SOCS1,predominance
R16481 T31296 T31294 pobj predominance,with
R16482 T31297 T31296 prep over,predominance
R16483 T31298 T31297 pobj SOCS3,over
R16484 T31299 T31293 punct .,associated
R16485 T31300 T31301 det These,abnormalities
R16486 T31301 T31306 nsubjpass abnormalities,thought
R16487 T31302 T31301 prep in,abnormalities
R16488 T31303 T31304 amod active,RA
R16489 T31304 T31302 pobj RA,in
R16490 T31305 T31306 auxpass are,thought
R16491 T31306 T31306 ROOT thought,thought
R16492 T31307 T31309 aux to,induced
R16493 T31308 T31309 auxpass be,induced
R16494 T31309 T31306 xcomp induced,thought
R16495 T31310 T31311 advmod mainly,after
R16496 T31311 T31309 prep after,induced
R16497 T31312 T31313 amod chronic,exposure
R16498 T31313 T31311 pobj exposure,after
R16499 T31314 T31313 prep to,exposure
R16500 T31315 T31316 amod high,concentrations
R16501 T31316 T31314 pobj concentrations,to
R16502 T31317 T31316 prep of,concentrations
R16503 T31318 T31317 pobj IL-6,of
R16504 T31319 T31306 punct .,thought
R16505 T31320 T31322 det The,efficacy
R16506 T31321 T31322 amod limited,efficacy
R16507 T31322 T31334 nsubjpass efficacy,explained
R16508 T31323 T31322 prep of,efficacy
R16509 T31324 T31325 amod IL-10,treatment
R16510 T31325 T31323 pobj treatment,of
R16511 T31326 T31325 prep of,treatment
R16512 T31327 T31328 compound RA,patients
R16513 T31328 T31326 pobj patients,of
R16514 T31329 T31322 appos [,efficacy
R16515 T31330 T31331 nummod 50,]
R16516 T31331 T31334 nsubjpass ],explained
R16517 T31332 T31334 aux may,explained
R16518 T31333 T31334 auxpass be,explained
R16519 T31334 T31334 ROOT explained,explained
R16520 T31335 T31334 prep in,explained
R16521 T31336 T31335 pobj part,in
R16522 T31337 T31334 agent by,explained
R16523 T31338 T31339 det the,unresponsiveness
R16524 T31339 T31337 pobj unresponsiveness,by
R16525 T31340 T31339 prep to,unresponsiveness
R16526 T31341 T31340 pobj IL-10,to
R16527 T31342 T31341 prep of,IL-10
R16528 T31343 T31344 amod inflammatory,cells
R16529 T31344 T31342 pobj cells,of
R16530 T31345 T31344 punct ",",cells
R16531 T31346 T31344 prep including,cells
R16532 T31347 T31348 compound T,cells
R16533 T31348 T31346 pobj cells,including
R16534 T31349 T31334 punct .,explained
R16535 T31350 T31363 prep On,reported
R16536 T31351 T31352 det the,contrary
R16537 T31352 T31350 pobj contrary,On
R16538 T31353 T31363 punct ",",reported
R16539 T31354 T31356 det the,efficacy
R16540 T31355 T31356 amod therapeutic,efficacy
R16541 T31356 T31363 nsubjpass efficacy,reported
R16542 T31357 T31356 prep of,efficacy
R16543 T31358 T31360 amod anti-IL-6,antibody
R16544 T31359 T31360 compound receptor,antibody
R16545 T31360 T31357 pobj antibody,of
R16546 T31361 T31363 aux has,reported
R16547 T31362 T31363 auxpass been,reported
R16548 T31363 T31363 ROOT reported,reported
R16549 T31364 T31363 prep in,reported
R16550 T31365 T31366 compound RA,patients
R16551 T31366 T31364 pobj patients,in
R16552 T31367 T31369 nmod [,]
R16553 T31368 T31369 nummod 51,]
R16554 T31369 T31363 dobj ],reported
R16555 T31370 T31369 punct ",",]
R16556 T31371 T31369 cc and,]
R16557 T31372 T31380 nsubj one,be
R16558 T31373 T31372 prep of,one
R16559 T31374 T31375 det the,effects
R16560 T31375 T31373 pobj effects,of
R16561 T31376 T31375 prep of,effects
R16562 T31377 T31378 det this,therapy
R16563 T31378 T31376 pobj therapy,of
R16564 T31379 T31380 aux may,be
R16565 T31380 T31363 ccomp be,reported
R16566 T31381 T31382 aux to,normalize
R16567 T31382 T31380 xcomp normalize,be
R16568 T31383 T31384 compound T,cells
R16569 T31384 T31382 dobj cells,normalize
R16570 T31385 T31382 prep through,normalize
R16571 T31386 T31387 det the,inhibition
R16572 T31387 T31385 pobj inhibition,through
R16573 T31388 T31387 prep of,inhibition
R16574 T31389 T31391 amod IL-6-dependent,activation
R16575 T31390 T31391 nummod STAT3,activation
R16576 T31391 T31388 pobj activation,of
R16577 T31392 T31363 punct .,reported
R16578 T31393 T31394 advmod More,specific
R16579 T31394 T31395 amod specific,therapy
R16580 T31395 T31401 nsubjpass therapy,awaited
R16581 T31396 T31395 acl targeting,therapy
R16582 T31397 T31398 nummod STAT3,activation
R16583 T31398 T31396 dobj activation,targeting
R16584 T31399 T31401 aux will,awaited
R16585 T31400 T31401 auxpass be,awaited
R16586 T31401 T31419 ccomp awaited,demonstrated
R16587 T31402 T31419 punct ;,demonstrated
R16588 T31403 T31419 prep for,demonstrated
R16589 T31404 T31403 pobj example,for
R16590 T31405 T31419 punct ",",demonstrated
R16591 T31406 T31407 det the,induction
R16592 T31407 T31419 nsubjpass induction,demonstrated
R16593 T31408 T31407 prep of,induction
R16594 T31409 T31411 det the,gene
R16595 T31410 T31411 nummod SOCS3,gene
R16596 T31411 T31408 pobj gene,of
R16597 T31412 T31407 punct ",",induction
R16598 T31413 T31414 det the,efficacy
R16599 T31414 T31407 conj efficacy,induction
R16600 T31415 T31414 prep of,efficacy
R16601 T31416 T31415 pobj which,of
R16602 T31417 T31419 aux has,demonstrated
R16603 T31418 T31419 auxpass been,demonstrated
R16604 T31419 T31419 ROOT demonstrated,demonstrated
R16605 T31420 T31419 prep in,demonstrated
R16606 T31421 T31422 compound animal,models
R16607 T31422 T31420 pobj models,in
R16608 T31423 T31425 nmod [,]
R16609 T31424 T31425 nummod 37,]
R16610 T31425 T31422 appos ],models
R16611 T31426 T31419 punct .,demonstrated
R1976 T4915 T4916 nsubj IL-10,is
R1978 T4916 T4916 ROOT is,is
R1979 T4917 T4919 det a,cytokine
R1982 T4918 T4919 amod key,cytokine
R1983 T4919 T4916 attr cytokine,is
R1984 T4920 T4919 prep in,cytokine
R1985 T4921 T4920 pcomp regulating,in
R1986 T4922 T4923 amod inflammatory,responses
R1987 T4923 T4921 dobj responses,regulating
R1988 T4924 T4919 punct ",",cytokine
R1989 T4971 T4972 nummod 1,]
R1990 T4972 T4970 appos ],[
R1991 T4973 T4937 punct .,binds
R1992 T4925 T4926 advmod mainly,by
R1993 T4974 T4975 det The,interaction
R1994 T4975 T4980 nsubj interaction,engages
R1995 T4976 T4975 prep of,interaction
R1996 T4926 T4916 prep by,is
R1997 T4977 T4976 pobj IL-10,of
R1998 T4978 T4977 cc and,IL-10
R1999 T4927 T4926 pcomp inhibiting,by
R2000 T4979 T4977 conj IL-10R,IL-10
R2001 T4980 T4980 ROOT engages,engages
R2002 T4981 T4983 det the,kinase
R2003 T4982 T4983 compound Janus,kinase
R2004 T4928 T4929 det the,production
R2005 T4983 T4980 dobj kinase,engages
R2006 T4984 T4983 punct (,kinase
R2007 T4985 T4983 appos JAK,kinase
R2008 T4929 T4927 dobj production,inhibiting
R2009 T4986 T4985 punct ),JAK
R2010 T4987 T4988 compound family,tyrosine
R2011 T4988 T4989 nsubj tyrosine,kinases
R2012 T4930 T4929 cc and,production
R2013 T4989 T4983 parataxis kinases,kinase
R2014 T4990 T4989 dobj Jak1,kinases
R2015 T4991 T4990 cc and,Jak1
R2016 T4931 T4929 conj function,production
R2017 T4932 T4929 prep of,production
R2018 T4992 T4990 conj Tyk2,Jak1
R2019 T4993 T4983 punct ",",kinase
R2020 T4933 T4934 amod proinflammatory,cytokines
R2021 T4994 T4997 nsubjpass which,associated
R2022 T4995 T4997 auxpass are,associated
R2023 T4996 T4997 advmod constitutively,associated
R2024 T4934 T4932 pobj cytokines,of
R2025 T4997 T4983 relcl associated,kinase
R2026 T4998 T4997 prep with,associated
R2027 T4999 T4998 pobj IL-10R1,with
R2028 T5000 T4997 cc and,associated
R2029 T5001 T5003 nmod type,IL-10R
R2030 T4935 T4916 punct .,is
R2031 T5002 T5003 nummod 2,IL-10R
R2032 T5003 T4997 conj IL-10R,associated
R2033 T5004 T5003 punct ",",IL-10R
R2034 T4936 T4937 amod IL-10,binds
R2035 T5005 T5006 advmod respectively,[
R2036 T5006 T5008 quantmod [,]
R2037 T5007 T5008 nummod 2,]
R2038 T5008 T5003 appos ],IL-10R
R2039 T4937 T4937 ROOT binds,binds
R2040 T5009 T4980 punct .,engages
R2041 T5010 T5011 nsubj IL-10,induces
R2042 T5011 T5011 ROOT induces,induces
R2043 T4938 T4937 prep to,binds
R2044 T5012 T5013 compound tyrosine,phosphorylation
R2045 T5013 T5011 dobj phosphorylation,induces
R2046 T4939 T4941 det the,receptor
R2047 T5014 T5013 cc and,phosphorylation
R2048 T5015 T5013 conj activation,phosphorylation
R2049 T5016 T5013 prep of,phosphorylation
R2050 T5017 T5020 det the,factors
R2051 T4940 T4941 compound IL-10,receptor
R2052 T5018 T5020 amod latent,factors
R2053 T5019 T5020 amod transcriptional,factors
R2054 T5020 T5016 pobj factors,of
R2055 T4941 T4938 pobj receptor,to
R2056 T5021 T5011 conj signal,induces
R2057 T5022 T5021 dobj transducer,signal
R2058 T5023 T5022 cc and,transducer
R2059 T4942 T4941 punct (,receptor
R2060 T5024 T5022 conj activator,transducer
R2061 T5025 T5024 prep of,activator
R2062 T5026 T5025 pobj transcription,of
R2063 T4943 T4941 appos IL-10R,receptor
R2064 T5027 T5026 punct (,transcription
R2065 T5028 T5026 appos STAT,transcription
R2066 T5029 T5026 punct ),transcription
R2067 T4944 T4941 punct ),receptor
R2068 T4945 T4937 appos complex,binds
R2069 T5030 T5026 nummod 3,transcription
R2070 T4946 T4948 nsubjpass that,composed
R2071 T5031 T5024 cc and,activator
R2072 T5032 T5033 nummod STAT1,[
R2073 T5033 T5024 conj [,activator
R2074 T4947 T4948 auxpass is,composed
R2075 T5034 T5035 nummod 3,]
R2076 T5035 T5033 appos ],[
R2077 T5036 T5011 punct .,induces
R2078 T5037 T5044 prep Upon,form
R2079 T5038 T5037 pobj phosphorylation,Upon
R2080 T5039 T5044 punct ",",form
R2081 T4948 T4937 relcl composed,binds
R2082 T5040 T5043 nmod STAT1,proteins
R2083 T5041 T5040 cc and,STAT1
R2084 T5042 T5040 conj STAT3,STAT1
R2085 T4949 T4948 prep of,composed
R2086 T5043 T5044 nsubj proteins,form
R2087 T5044 T5044 ROOT form,form
R2088 T5045 T5044 dobj homodimers,form
R2089 T4950 T4951 nummod two,subunits
R2090 T5046 T5045 cc or,homodimers
R2091 T5047 T5045 conj heterodimers,homodimers
R2092 T5048 T5044 punct ",",form
R2093 T4951 T4949 pobj subunits,of
R2094 T5049 T5050 advmod rapidly,translocate
R2095 T5050 T5044 conj translocate,form
R2096 T5051 T5050 prep into,translocate
R2097 T4952 T4951 punct ",",subunits
R2098 T5052 T5053 det the,nucleus
R2099 T5053 T5051 pobj nucleus,into
R2100 T5054 T5050 punct ",",translocate
R2101 T4953 T4956 det the,component
R2102 T5055 T5050 cc and,translocate
R2103 T5056 T5050 conj modulate,translocate
R2104 T5057 T5058 compound gene,transcription
R2105 T4954 T4956 amod primary,component
R2106 T5058 T5056 dobj transcription,modulate
R2107 T5059 T5044 punct .,form
R2108 T5060 T5063 advmod Intriguingly,is
R2109 T4955 T4956 amod ligand-binding,component
R2110 T5061 T5063 punct ",",is
R2111 T5062 T5063 nsubj STAT3,is
R2112 T5063 T5063 ROOT is,is
R2113 T4956 T4957 compound component,type
R2114 T5064 T5063 acomp indispensable,is
R2115 T5065 T5063 prep for,is
R2116 T5066 T5072 det both,responses
R2117 T4957 T4951 appos type,subunits
R2118 T5067 T5072 amod IL-10-derived,responses
R2119 T4958 T4959 nummod 1,IL-10R
R2120 T4959 T4957 appos IL-10R,type
R2121 T5068 T5072 nmod anti-inflammatory,responses
R2122 T4960 T4961 punct (,IL-10R1
R2123 T5069 T5068 cc and,anti-inflammatory
R2124 T5070 T5068 conj IL-6-derived,anti-inflammatory
R2125 T4961 T4959 appos IL-10R1,IL-10R
R2126 T5071 T5072 amod proinflammatory,responses
R2127 T5072 T5065 pobj responses,for
R2128 T4962 T4961 punct ),IL-10R1
R2129 T5073 T5075 nmod [,]
R2130 T5074 T5075 nummod 4,]
R2131 T5075 T5063 npadvmod ],is
R2132 T4963 T4959 cc and,IL-10R
R2133 T5076 T5063 punct .,is
R2134 T5077 T5083 nsubj Studies,shown
R2135 T4964 T4966 det the,component
R2136 T5078 T5077 prep of,Studies
R2137 T5079 T5081 amod cell-type-specific,mice
R2138 T4965 T4966 compound accessory,component
R2139 T5080 T5081 amod STAT3-deficient,mice
R2140 T5081 T5078 pobj mice,of
R2141 T5082 T5083 aux have,shown
R2142 T4966 T4967 compound component,type
R2143 T5083 T5083 ROOT shown,shown
R2144 T5084 T5087 mark that,is
R2145 T4967 T4959 conj type,IL-10R
R2146 T5085 T5086 nummod STAT3,activation
R2147 T5086 T5087 nsubj activation,is
R2148 T5087 T5083 ccomp is,shown
R2149 T4968 T4967 nummod 2,type
R2150 T5088 T5087 acomp essential,is
R2151 T5089 T5088 prep for,essential
R2152 T5090 T5092 amod IL-10-mediated,reactions
R2153 T4969 T4970 compound IL-10R,[
R2154 T5091 T5092 amod anti-inflammatory,reactions
R2155 T5092 T5089 pobj reactions,for
R2156 T5093 T5092 prep in,reactions
R2157 T4970 T4967 appos [,type
R2158 T5094 T5093 pobj macrophages,in
R2159 T5095 T5094 cc and,macrophages
R2160 T5096 T5094 conj neutrophils,macrophages
R2161 T5165 T5127 punct .,identified
R2162 T5097 T5099 nmod [,]
R2163 T5098 T5099 nummod 5,]
R2164 T5099 T5083 dobj ],shown
R2165 T5100 T5083 punct ",",shown
R2166 T5166 T5167 amod Recent,studies
R2167 T5101 T5083 cc but,shown
R2168 T5102 T5083 conj is,shown
R2169 T5103 T5102 acomp responsible,is
R2170 T5104 T5103 prep for,responsible
R2171 T5167 T5168 nsubj studies,indicate
R2172 T5105 T5106 amod IL-6-mediated,prevention
R2173 T5106 T5104 pobj prevention,for
R2174 T5107 T5106 prep of,prevention
R2175 T5168 T5168 ROOT indicate,indicate
R2176 T5108 T5107 pobj apoptosis,of
R2177 T5109 T5106 prep in,prevention
R2178 T5110 T5111 compound T,cells
R2179 T5111 T5109 pobj cells,in
R2180 T5112 T5114 nmod [,]
R2181 T5113 T5114 nummod 6,]
R2182 T5169 T5171 mark that,plays
R2183 T5114 T5114 ROOT ],]
R2184 T5115 T5083 punct .,shown
R2185 T5116 T5117 det The,suppressor
R2186 T5170 T5171 nsubj SOCS3,plays
R2187 T5117 T5117 ROOT suppressor,suppressor
R2188 T5118 T5117 prep of,suppressor
R2189 T5119 T5118 pobj cytokine,of
R2190 T5171 T5168 ccomp plays,indicate
R2191 T5120 T5117 acl signaling,suppressor
R2192 T5121 T5120 punct (,signaling
R2193 T5122 T5120 appos SOCS,signaling
R2194 T5172 T5174 det a,role
R2195 T5123 T5120 punct ),signaling
R2196 T5124 T5127 nsubjpass proteins,identified
R2197 T5125 T5127 aux have,identified
R2198 T5173 T5174 amod key,role
R2199 T5126 T5127 auxpass been,identified
R2200 T5127 T5127 ROOT identified,identified
R2201 T5128 T5127 prep as,identified
R2202 T5174 T5171 dobj role,plays
R2203 T5129 T5130 det a,family
R2204 T5130 T5128 pobj family,as
R2205 T5175 T5174 prep in,role
R2206 T5131 T5130 prep of,family
R2207 T5132 T5135 amod endogenous,inhibitors
R2208 T5133 T5135 nmod JAK,inhibitors
R2209 T5134 T5135 compound kinase,inhibitors
R2210 T5176 T5175 pcomp regulating,in
R2211 T5135 T5131 pobj inhibitors,of
R2212 T5136 T5138 nsubj that,act
R2213 T5137 T5138 aux can,act
R2214 T5177 T5179 det the,action
R2215 T5138 T5135 relcl act,inhibitors
R2216 T5139 T5138 prep in,act
R2217 T5140 T5143 amod classic,loops
R2218 T5178 T5179 amod divergent,action
R2219 T5141 T5142 compound feedback,inhibition
R2220 T5142 T5143 compound inhibition,loops
R2221 T5143 T5139 pobj loops,in
R2222 T5179 T5176 dobj action,regulating
R2223 T5144 T5127 punct ",",identified
R2224 T5145 T5127 cc but,identified
R2225 T5146 T5147 poss their,roles
R2226 T5180 T5179 prep of,action
R2227 T5147 T5127 conj roles,identified
R2228 T5148 T5147 prep as,roles
R2229 T5149 T5150 det the,mediators
R2230 T5150 T5148 pobj mediators,as
R2231 T5181 T5180 pobj IL-10,of
R2232 T5151 T5150 prep of,mediators
R2233 T5152 T5153 compound crosstalk,inhibition
R2234 T5153 T5151 pobj inhibition,of
R2235 T5182 T5181 cc and,IL-10
R2236 T5154 T5127 agent by,identified
R2237 T5155 T5154 pcomp opposing,by
R2238 T5156 T5155 dobj cytokine,opposing
R2239 T5183 T5181 conj IL-6,IL-10
R2240 T5157 T5155 conj signaling,opposing
R2241 T5158 T5161 nsubjpass pathways,clarified
R2242 T5184 T5171 punct ",",plays
R2243 T5159 T5161 aux have,clarified
R2244 T5160 T5161 auxpass been,clarified
R2245 T5161 T5157 ccomp clarified,signaling
R2246 T5185 T5171 prep by,plays
R2247 T5162 T5164 nmod [,]
R2248 T5163 T5164 nummod 7,]
R2249 T5164 T5161 dobj ],clarified
R2250 T5186 T5187 advmod specifically,blocking
R2251 T5187 T5185 pcomp blocking,by
R2252 T5188 T5189 nummod STAT3,activation
R2253 T5189 T5187 dobj activation,blocking
R2254 T5262 T5260 pobj cytokines,of
R2255 T5263 T5256 punct .,are
R2256 T5190 T5189 acl induced,activation
R2257 T5264 T5267 compound Tumor,alpha
R2258 T5265 T5266 compound necrosis,factor
R2259 T5266 T5267 compound factor,alpha
R2260 T5191 T5190 agent by,induced
R2261 T5267 T5279 nsubj alpha,are
R2262 T5268 T5269 punct (,TNF-α
R2263 T5269 T5267 appos TNF-α,alpha
R2264 T5192 T5191 pobj IL-6,by
R2265 T5270 T5269 punct ),TNF-α
R2266 T5271 T5267 cc and,alpha
R2267 T5272 T5267 conj IL-1,alpha
R2268 T5193 T5190 cc but,induced
R2269 T5273 T5272 punct ",",IL-1
R2270 T5274 T5277 nummod two,products
R2271 T5275 T5277 amod major,products
R2272 T5194 T5196 neg not,induced
R2273 T5276 T5277 compound macrophage,products
R2274 T5277 T5267 appos products,alpha
R2275 T5195 T5196 nsubj that,induced
R2276 T5278 T5279 punct ",",are
R2277 T5279 T5279 ROOT are,are
R2278 T5280 T5279 acomp crucial,are
R2279 T5281 T5279 prep in,are
R2280 T5282 T5283 det the,process
R2281 T5283 T5281 pobj process,in
R2282 T5284 T5283 prep of,process
R2283 T5196 T5190 conj induced,induced
R2284 T5285 T5286 amod chronic,inflammation
R2285 T5286 T5284 pobj inflammation,of
R2286 T5287 T5286 cc and,inflammation
R2287 T5197 T5196 agent by,induced
R2288 T5288 T5289 amod joint,destruction
R2289 T5289 T5286 conj destruction,inflammation
R2290 T5290 T5279 punct ",",are
R2291 T5198 T5199 compound IL-10,[
R2292 T5291 T5279 cc and,are
R2293 T5292 T5293 nsubj they,give
R2294 T5293 T5279 conj give,are
R2295 T5199 T5197 pobj [,by
R2296 T5294 T5293 dobj rise,give
R2297 T5295 T5296 aux to,effector
R2298 T5200 T5201 nummod "8,9",]
R2299 T5296 T5294 advcl effector,rise
R2300 T5297 T5296 dobj components,effector
R2301 T5298 T5297 punct ",",components
R2302 T5299 T5297 prep including,components
R2303 T5201 T5199 appos ],[
R2304 T5300 T5302 amod other,cytokines
R2305 T5301 T5302 amod inflammatory,cytokines
R2306 T5302 T5299 pobj cytokines,including
R2307 T5202 T5168 punct .,indicate
R2308 T5303 T5302 punct ",",cytokines
R2309 T5304 T5302 conj chemokines,cytokines
R2310 T5305 T5304 punct ",",chemokines
R2311 T5203 T5205 det The,membrane
R2312 T5306 T5307 compound growth,factors
R2313 T5307 T5304 conj factors,chemokines
R2314 T5204 T5205 amod synovial,membrane
R2315 T5205 T5213 nsubjpass membrane,characterized
R2316 T5308 T5307 punct ",",factors
R2317 T5309 T5310 compound matrix,proteases
R2318 T5206 T5205 prep of,membrane
R2319 T5310 T5307 conj proteases,factors
R2320 T5207 T5208 amod rheumatoid,arthritis
R2321 T5208 T5206 pobj arthritis,of
R2322 T5311 T5310 punct ",",proteases
R2323 T5312 T5313 amod nitric,oxide
R2324 T5313 T5310 conj oxide,proteases
R2325 T5209 T5210 punct (,RA
R2326 T5314 T5313 punct ",",oxide
R2327 T5315 T5313 cc and,oxide
R2328 T5316 T5318 amod reactive,species
R2329 T5317 T5318 compound oxygen,species
R2330 T5210 T5208 appos RA,arthritis
R2331 T5318 T5313 conj species,oxide
R2332 T5319 T5321 nmod [,]
R2333 T5320 T5321 nummod 10,]
R2334 T5321 T5297 appos ],components
R2335 T5211 T5205 punct ),membrane
R2336 T5322 T5293 punct .,give
R2337 T5323 T5324 nsubj IL-6,is
R2338 T5212 T5213 auxpass is,characterized
R2339 T5324 T5324 ROOT is,is
R2340 T5325 T5327 det a,cytokine
R2341 T5326 T5327 amod pleiotropic,cytokine
R2342 T5213 T5213 ROOT characterized,characterized
R2343 T5327 T5324 attr cytokine,is
R2344 T5328 T5327 acl produced,cytokine
R2345 T5214 T5213 agent by,characterized
R2346 T5329 T5328 advmod substantially,produced
R2347 T5330 T5328 agent by,produced
R2348 T5331 T5332 amod activated,fibroblasts
R2349 T5215 T5216 det an,infiltrate
R2350 T5332 T5330 pobj fibroblasts,by
R2351 T5333 T5328 punct ",",produced
R2352 T5334 T5327 cc and,cytokine
R2353 T5335 T5337 poss its,actions
R2354 T5216 T5214 pobj infiltrate,by
R2355 T5336 T5337 amod proinflammatory,actions
R2356 T5337 T5338 nsubj actions,include
R2357 T5217 T5216 prep of,infiltrate
R2358 T5338 T5324 conj include,is
R2359 T5339 T5338 xcomp simulating,include
R2360 T5340 T5342 det the,response
R2361 T5218 T5219 det a,variety
R2362 T5341 T5342 amod acute-phase,response
R2363 T5342 T5339 dobj response,simulating
R2364 T5343 T5339 punct ",",simulating
R2365 T5219 T5217 pobj variety,of
R2366 T5344 T5345 compound B-cell,maturation
R2367 T5345 T5339 conj maturation,simulating
R2368 T5220 T5219 prep of,variety
R2369 T5221 T5222 amod inflammatory,cells
R2370 T5346 T5345 prep into,maturation
R2371 T5347 T5348 compound plasma,cells
R2372 T5222 T5220 pobj cells,of
R2373 T5348 T5346 pobj cells,into
R2374 T5349 T5345 punct ",",maturation
R2375 T5350 T5351 compound T-cell,functions
R2376 T5223 T5222 punct ",",cells
R2377 T5351 T5345 conj functions,maturation
R2378 T5352 T5351 punct ",",functions
R2379 T5353 T5351 cc and,functions
R2380 T5224 T5225 amod such,as
R2381 T5354 T5356 amod hematopoietic,cell
R2382 T5355 T5356 compound precursor,cell
R2383 T5225 T5222 prep as,cells
R2384 T5356 T5357 compound cell,differentiation
R2385 T5357 T5351 conj differentiation,functions
R2386 T5358 T5360 nmod [,]
R2387 T5226 T5225 pobj lymphocytes,as
R2388 T5359 T5360 nummod 11,]
R2389 T5360 T5357 appos ],differentiation
R2390 T5361 T5338 punct .,include
R2391 T5227 T5226 punct ",",lymphocytes
R2392 T5362 T5369 advmod However,are
R2393 T5228 T5226 conj macrophages,lymphocytes
R2394 T5363 T5369 punct ",",are
R2395 T5364 T5365 amod anti-inflammatory,cytokines
R2396 T5365 T5369 nsubj cytokines,are
R2397 T5229 T5228 punct ",",macrophages
R2398 T5366 T5365 cc and,cytokines
R2399 T5367 T5368 compound cytokine,inhibitors
R2400 T5368 T5365 conj inhibitors,cytokines
R2401 T5230 T5228 cc and,macrophages
R2402 T5369 T5369 ROOT are,are
R2403 T5370 T5369 advmod also,are
R2404 T5371 T5369 acomp present,are
R2405 T5231 T5232 amod dendritic,cells
R2406 T5372 T5371 prep in,present
R2407 T5373 T5374 amod large,quantities
R2408 T5374 T5372 pobj quantities,in
R2409 T5232 T5228 conj cells,macrophages
R2410 T5375 T5369 prep in,are
R2411 T5376 T5377 compound RA,joints
R2412 T5377 T5375 pobj joints,in
R2413 T5233 T5216 punct ",",infiltrate
R2414 T5378 T5369 punct .,are
R2415 T5379 T5399 nsubjpass IL-10,known
R2416 T5380 T5379 punct ",",IL-10
R2417 T5234 T5235 advmod together,with
R2418 T5381 T5379 acl produced,IL-10
R2419 T5382 T5381 agent by,produced
R2420 T5235 T5216 prep with,infiltrate
R2421 T5383 T5382 pobj macrophages,by
R2422 T5384 T5381 cc and,produced
R2423 T5385 T5386 advmod partly,by
R2424 T5386 T5399 prep by,known
R2425 T5236 T5235 pobj proliferation,with
R2426 T5387 T5388 compound T,cells
R2427 T5388 T5386 pobj cells,by
R2428 T5237 T5236 prep of,proliferation
R2429 T5389 T5388 prep in,cells
R2430 T5390 T5392 det the,tissue
R2431 T5391 T5392 amod synovial,tissue
R2432 T5392 T5389 pobj tissue,in
R2433 T5393 T5394 punct (,ST
R2434 T5394 T5392 appos ST,tissue
R2435 T5395 T5392 punct ),tissue
R2436 T5238 T5240 amod synovial,cells
R2437 T5239 T5240 amod fibroblast-like,cells
R2438 T5396 T5397 punct ",",is
R2439 T5397 T5399 auxpass is,known
R2440 T5398 T5399 advmod best,known
R2441 T5240 T5237 pobj cells,of
R2442 T5399 T5399 ROOT known,known
R2443 T5400 T5399 prep as,known
R2444 T5241 T5213 punct .,characterized
R2445 T5401 T5403 det a,regulator
R2446 T5402 T5403 amod negative,regulator
R2447 T5403 T5400 pobj regulator,as
R2448 T5242 T5243 amod Numerous,cytokines
R2449 T5404 T5403 prep for,regulator
R2450 T5243 T5245 nsubjpass cytokines,overproduced
R2451 T5244 T5245 auxpass are,overproduced
R2452 T5405 T5404 pobj macrophage,for
R2453 T5406 T5405 cc and,macrophage
R2454 T5245 T5245 ROOT overproduced,overproduced
R2455 T5407 T5408 amod Th1,cells
R2456 T5408 T5405 conj cells,macrophage
R2457 T5409 T5399 punct ",",known
R2458 T5246 T5245 prep in,overproduced
R2459 T5410 T5399 cc but,known
R2460 T5411 T5413 det the,level
R2461 T5247 T5249 det the,joint
R2462 T5412 T5413 compound expression,level
R2463 T5413 T5414 nsubj level,is
R2464 T5248 T5249 amod inflamed,joint
R2465 T5414 T5399 conj is,known
R2466 T5249 T5246 pobj joint,in
R2467 T5415 T5414 acomp insufficient,is
R2468 T5416 T5417 aux to,counterbalance
R2469 T5417 T5415 xcomp counterbalance,insufficient
R2470 T5250 T5245 punct ",",overproduced
R2471 T5418 T5419 det the,cascade
R2472 T5419 T5417 dobj cascade,counterbalance
R2473 T5420 T5419 prep of,cascade
R2474 T5421 T5422 amod proinflammatory,events
R2475 T5251 T5245 cc and,overproduced
R2476 T5422 T5420 pobj events,of
R2477 T5423 T5425 nmod [,]
R2478 T5252 T5256 nsubj macrophages,are
R2479 T5424 T5425 nummod 12,]
R2480 T5425 T5419 appos ],cascade
R2481 T5426 T5414 punct .,is
R2482 T5427 T5435 prep In,appears
R2483 T5428 T5427 pobj addition,In
R2484 T5429 T5435 punct ",",appears
R2485 T5430 T5432 det the,action
R2486 T5253 T5252 cc and,macrophages
R2487 T5431 T5432 amod anti-inflammatory,action
R2488 T5432 T5435 nsubj action,appears
R2489 T5433 T5432 prep of,action
R2490 T5254 T5255 amod synovial,fibroblasts
R2491 T5434 T5433 pobj IL-10,of
R2492 T5435 T5435 ROOT appears,appears
R2493 T5255 T5252 conj fibroblasts,macrophages
R2494 T5436 T5438 aux to,modulated
R2495 T5437 T5438 auxpass be,modulated
R2496 T5438 T5435 xcomp modulated,appears
R2497 T5256 T5245 conj are,overproduced
R2498 T5439 T5438 prep at,modulated
R2499 T5440 T5441 det the,level
R2500 T5441 T5439 pobj level,at
R2501 T5257 T5259 det an,source
R2502 T5258 T5259 amod important,source
R2503 T5442 T5441 prep of,level
R2504 T5259 T5256 attr source,are
R2505 T5443 T5444 compound signal,transduction
R2506 T5444 T5442 pobj transduction,of
R2507 T5445 T5438 prep during,modulated
R2508 T5260 T5259 prep of,source
R2509 T5446 T5447 amod chronic,inflammation
R2510 T5447 T5445 pobj inflammation,during
R2511 T5448 T5435 punct .,appears
R2512 T5261 T5262 amod proinflammatory,cytokines
R2513 T5449 T5452 nsubjpass IL-10,impaired
R2514 T5450 T5452 nsubjpass signaling,impaired
R2515 T5451 T5452 auxpass is,impaired
R2516 T5506 T5509 nsubjpass cells,activated
R2517 T5452 T5452 ROOT impaired,impaired
R2518 T5453 T5452 prep in,impaired
R2519 T5454 T5453 pobj macrophages,in
R2520 T5507 T5509 aux may,activated
R2521 T5455 T5452 prep upon,impaired
R2522 T5456 T5457 amod chronic,exposure
R2523 T5457 T5455 pobj exposure,upon
R2524 T5508 T5509 auxpass be,activated
R2525 T5458 T5457 prep to,exposure
R2526 T5459 T5460 amod proinflammatory,cytokines
R2527 T5460 T5458 pobj cytokines,to
R2528 T5509 T5509 ROOT activated,activated
R2529 T5461 T5462 amod such,as
R2530 T5462 T5460 prep as,cytokines
R2531 T5463 T5468 nmod TNF-α,complexes
R2532 T5464 T5463 cc and,TNF-α
R2533 T5465 T5463 conj IL-1,TNF-α
R2534 T5466 T5465 cc and,IL-1
R2535 T5510 T5509 agent by,activated
R2536 T5467 T5465 conj immune,IL-1
R2537 T5468 T5462 pobj complexes,as
R2538 T5469 T5471 compound [,]
R2539 T5511 T5512 amod arthritogenic,antigens
R2540 T5470 T5471 compound "13,14",]
R2541 T5471 T5468 appos ],complexes
R2542 T5472 T5452 punct .,impaired
R2543 T5512 T5510 pobj antigens,by
R2544 T5473 T5474 compound Cell,surface
R2545 T5474 T5475 compound surface,expression
R2546 T5513 T5509 punct ",",activated
R2547 T5475 T5479 nsubjpass expression,decreased
R2548 T5476 T5475 prep of,expression
R2549 T5477 T5476 pobj IL-10R1,of
R2550 T5478 T5479 auxpass is,decreased
R2551 T5514 T5509 prep in,activated
R2552 T5479 T5479 ROOT decreased,decreased
R2553 T5480 T5479 prep in,decreased
R2554 T5515 T5514 pobj conjunction,in
R2555 T5481 T5484 amod synovial,cells
R2556 T5482 T5484 amod fluid,cells
R2557 T5483 T5484 amod dendritic,cells
R2558 T5516 T5515 prep with,conjunction
R2559 T5484 T5480 pobj cells,in
R2560 T5485 T5479 conj due,decreased
R2561 T5517 T5519 nsubj CD28-mediated,signaling
R2562 T5486 T5485 pcomp to,due
R2563 T5487 T5488 det the,presence
R2564 T5488 T5485 pobj presence,due
R2565 T5518 T5519 amod costimulatory,signaling
R2566 T5489 T5488 prep of,presence
R2567 T5490 T5489 pobj TNF-α,of
R2568 T5519 T5516 pcomp signaling,with
R2569 T5491 T5490 punct ",",TNF-α
R2570 T5492 T5490 conj IL-1,TNF-α
R2571 T5520 T5519 punct ",",signaling
R2572 T5493 T5492 punct ",",IL-1
R2573 T5521 T5519 prep in,signaling
R2574 T5494 T5492 cc and,IL-1
R2575 T5495 T5492 conj granulocyte,IL-1
R2576 T5496 T5498 nmod macrophage,factor
R2577 T5522 T5521 pobj RA,in
R2578 T5497 T5498 compound colony-stimulating,factor
R2579 T5498 T5488 appos factor,presence
R2580 T5499 T5501 nmod [,]
R2581 T5500 T5501 nummod 15,]
R2582 T5501 T5498 appos ],factor
R2583 T5523 T5509 punct .,activated
R2584 T5502 T5479 punct .,decreased
R2585 T5503 T5509 nsubjpass CD4,activated
R2586 T5504 T5506 nummod +,cells
R2587 T5524 T5525 det The,significance
R2588 T5505 T5506 compound T,cells
R2589 T5525 T5532 nsubjpass significance,supported
R2590 T5526 T5525 prep of,significance
R2591 T5537 T5541 det the,antigens
R2592 T5538 T5540 compound MHC,II
R2593 T5527 T5529 det this,process
R2594 T5539 T5540 compound class,II
R2595 T5540 T5541 compound II,antigens
R2596 T5528 T5529 amod autoimmune,process
R2597 T5541 T5536 pobj antigens,of
R2598 T5542 T5541 appos HLA-DRB1,antigens
R2599 T5529 T5526 pobj process,of
R2600 T5543 T5532 punct *,supported
R2601 T5544 T5544 ROOT 0404,0404
R2602 T5545 T5544 cc and,0404
R2603 T5530 T5532 aux has,supported
R2604 T5546 T5544 conj HLA-DRB1,0404
R2605 T5547 T5546 punct *,HLA-DRB1
R2606 T5548 T5546 amod 0401,HLA-DRB1
R2607 T5531 T5532 auxpass been,supported
R2608 T5549 T5546 prep with,HLA-DRB1
R2609 T5550 T5551 compound disease,susceptibility
R2610 T5551 T5549 pobj susceptibility,with
R2611 T5532 T5532 ROOT supported,supported
R2612 T5552 T5551 cc and,susceptibility
R2613 T5553 T5551 conj severity,susceptibility
R2614 T5554 T5556 compound [,]
R2615 T5555 T5556 compound "16,17",]
R2616 T5533 T5532 agent by,supported
R2617 T5556 T5546 conj ],HLA-DRB1
R2618 T5557 T5556 punct ",",]
R2619 T5558 T5544 cc and,0404
R2620 T5534 T5535 det the,linkage
R2621 T5559 T5544 conj by,0404
R2622 T5560 T5562 det the,expression
R2623 T5561 T5562 amod high-level,expression
R2624 T5535 T5533 pobj linkage,by
R2625 T5562 T5559 pobj expression,by
R2626 T5563 T5562 prep of,expression
R2627 T5564 T5567 compound MHC,molecules
R2628 T5536 T5535 prep of,linkage
R2629 T5565 T5567 compound class,molecules
R2630 T5566 T5567 compound II,molecules
R2631 T5567 T5563 pobj molecules,of
R2632 T5568 T5544 cc and,0404
R2633 T5569 T5571 det both,ligands
R2634 T5604 T5602 prep in,be
R2635 T5570 T5571 nummod CD28,ligands
R2636 T5605 T5604 pcomp sustaining,in
R2637 T5571 T5544 conj ligands,0404
R2638 T5572 T5571 punct ",",ligands
R2639 T5573 T5571 conj CD80,ligands
R2640 T5574 T5573 cc and,CD80
R2641 T5606 T5607 det the,activation
R2642 T5575 T5573 conj CD86,CD80
R2643 T5576 T5571 punct ",",ligands
R2644 T5577 T5544 prep in,0404
R2645 T5607 T5605 dobj activation,sustaining
R2646 T5578 T5583 det the,]
R2647 T5579 T5583 amod inflamed,]
R2648 T5608 T5607 prep of,activation
R2649 T5580 T5581 compound ST,[
R2650 T5581 T5583 nmod [,]
R2651 T5609 T5608 pobj macrophages,of
R2652 T5582 T5583 nummod 18-20,]
R2653 T5583 T5577 pobj ],in
R2654 T5584 T5544 punct .,0404
R2655 T5610 T5609 cc and,macrophages
R2656 T5585 T5587 det The,emergence
R2657 T5586 T5587 amod continuing,emergence
R2658 T5587 T5602 nsubj emergence,be
R2659 T5611 T5612 amod synovial,fibroblasts
R2660 T5588 T5587 prep of,emergence
R2661 T5589 T5593 amod activated,cells
R2662 T5612 T5609 conj fibroblasts,macrophages
R2663 T5590 T5593 compound CD4,cells
R2664 T5591 T5593 nummod +,cells
R2665 T5613 T5605 prep through,sustaining
R2666 T5592 T5593 compound T,cells
R2667 T5593 T5588 pobj cells,of
R2668 T5594 T5587 punct ",",emergence
R2669 T5614 T5615 compound cell,surface
R2670 T5595 T5597 advmod even,few
R2671 T5596 T5597 advmod though,few
R2672 T5597 T5602 advcl few,be
R2673 T5615 T5613 pobj surface,through
R2674 T5598 T5597 prep in,few
R2675 T5599 T5598 pobj number,in
R2676 T5600 T5602 punct ",",be
R2677 T5616 T5605 conj signaling,sustaining
R2678 T5601 T5602 aux may,be
R2679 T5602 T5602 ROOT be,be
R2680 T5603 T5602 acomp crucial,be
R2681 T5617 T5616 prep by,signaling
R2682 T5633 T5634 amod Th1,cytokines
R2683 T5618 T5617 pobj means,by
R2684 T5634 T5631 pobj cytokines,of
R2685 T5635 T5636 amod such,as
R2686 T5636 T5634 prep as,cytokines
R2687 T5619 T5618 prep of,means
R2688 T5637 T5638 compound interferon,gamma
R2689 T5638 T5636 pobj gamma,as
R2690 T5639 T5640 punct (,IFN
R2691 T5620 T5621 compound cell,surface
R2692 T5640 T5638 appos IFN,gamma
R2693 T5641 T5640 punct ),IFN
R2694 T5642 T5638 punct -,gamma
R2695 T5621 T5622 compound surface,CD69
R2696 T5643 T5638 conj γ,gamma
R2697 T5644 T5643 cc and,γ
R2698 T5645 T5646 compound IL-17,[
R2699 T5622 T5619 pobj CD69,of
R2700 T5646 T5630 appos [,release
R2701 T5647 T5648 compound "21,22",]
R2702 T5648 T5646 appos ],[
R2703 T5623 T5622 cc and,CD69
R2704 T5649 T5602 punct .,be
R2705 T5624 T5622 conj CD11,CD69
R2706 T5650 T5658 prep In,stimulate
R2707 T5625 T5616 punct ",",signaling
R2708 T5651 T5650 pobj addition,In
R2709 T5652 T5658 punct ",",stimulate
R2710 T5653 T5655 compound CD4,T
R2711 T5626 T5628 advmod as,as
R2712 T5654 T5655 compound +,T
R2713 T5655 T5656 compound T,cells
R2714 T5656 T5658 nsubj cells,stimulate
R2715 T5627 T5628 advmod well,as
R2716 T5657 T5658 aux could,stimulate
R2717 T5658 T5658 ROOT stimulate,stimulate
R2718 T5628 T5630 cc as,release
R2719 T5659 T5660 amod B-cell,production
R2720 T5660 T5658 dobj production,stimulate
R2721 T5629 T5630 det the,release
R2722 T5661 T5660 prep of,production
R2723 T5662 T5661 pobj autoantibodies,of
R2724 T5663 T5664 amod such,as
R2725 T5630 T5602 advcl release,be
R2726 T5664 T5662 prep as,autoantibodies
R2727 T5665 T5666 amod rheumatoid,factor
R2728 T5666 T5664 pobj factor,as
R2729 T5631 T5630 prep of,release
R2730 T5667 T5666 cc and,factor
R2731 T5668 T5670 amod osteoclast-mediated,destruction
R2732 T5669 T5670 compound bone,destruction
R2733 T5670 T5666 conj destruction,factor
R2734 T5671 T5658 punct .,stimulate
R2735 T5632 T5634 amod proinflammatory,cytokines
R2736 T5672 T5674 poss Their,role
R2737 T5673 T5674 amod obligatory,role
R2738 T5674 T5680 nsubjpass role,proved
R2739 T5704 T5705 punct -,IgG
R2740 T5675 T5674 prep in,role
R2741 T5676 T5677 compound RA,synovitis
R2742 T5677 T5675 pobj synovitis,in
R2743 T5678 T5680 auxpass was,proved
R2744 T5679 T5680 advmod recently,proved
R2745 T5680 T5680 ROOT proved,proved
R2746 T5705 T5695 appos IgG,protein
R2747 T5681 T5680 agent by,proved
R2748 T5682 T5683 amod successful,treatment
R2749 T5683 T5681 pobj treatment,by
R2750 T5706 T5695 punct ",",protein
R2751 T5684 T5683 prep of,treatment
R2752 T5685 T5686 amod active,disease
R2753 T5686 T5684 pobj disease,of
R2754 T5687 T5680 agent by,proved
R2755 T5707 T5709 nsubj which,block
R2756 T5688 T5689 amod selective,inhibition
R2757 T5689 T5687 pobj inhibition,by
R2758 T5690 T5689 prep of,inhibition
R2759 T5708 T5709 aux can,block
R2760 T5691 T5692 compound T-cell,activation
R2761 T5692 T5690 pobj activation,of
R2762 T5693 T5680 prep with,proved
R2763 T5709 T5695 relcl block,protein
R2764 T5694 T5695 compound fusion,protein
R2765 T5695 T5693 pobj protein,with
R2766 T5710 T5711 det the,engagement
R2767 T5696 T5695 prep of,protein
R2768 T5697 T5699 amod cytotoxic,antigen
R2769 T5698 T5699 amod T-cell-associated,antigen
R2770 T5699 T5696 pobj antigen,of
R2771 T5711 T5709 dobj engagement,block
R2772 T5700 T5699 nummod 4,antigen
R2773 T5701 T5699 punct (,antigen
R2774 T5702 T5699 appos CD152,antigen
R2775 T5712 T5711 prep of,engagement
R2776 T5703 T5699 punct ),antigen
R2777 T5713 T5712 pobj CD28,of
R2778 T5714 T5709 prep on,block
R2779 T5715 T5716 compound T,cells
R2780 T5729 T5680 punct .,proved
R2781 T5730 T5732 nsubj IL-10,blocks
R2782 T5731 T5732 advmod efficiently,blocks
R2783 T5732 T5732 ROOT blocks,blocks
R2784 T5716 T5714 pobj cells,on
R2785 T5733 T5737 det the,response
R2786 T5734 T5737 amod antigen-specific,response
R2787 T5735 T5737 compound T-cell,response
R2788 T5717 T5709 prep by,block
R2789 T5736 T5737 compound cytokine,response
R2790 T5737 T5732 dobj response,blocks
R2791 T5718 T5717 pobj binding,by
R2792 T5738 T5732 prep by,blocks
R2793 T5739 T5738 pcomp inhibiting,by
R2794 T5719 T5718 prep to,binding
R2795 T5740 T5741 det the,CD28
R2796 T5741 T5739 dobj CD28,inhibiting
R2797 T5742 T5739 conj signaling,inhibiting
R2798 T5720 T5719 pobj CD80,to
R2799 T5743 T5746 compound pathway,]
R2800 T5744 T5746 nmod [,]
R2801 T5745 T5746 nummod 24,]
R2802 T5721 T5720 cc and,CD80
R2803 T5746 T5742 dobj ],signaling
R2804 T5747 T5746 punct ",",]
R2805 T5748 T5750 advmod as,as
R2806 T5722 T5720 conj CD86,CD80
R2807 T5749 T5750 advmod well,as
R2808 T5750 T5746 cc as,]
R2809 T5751 T5742 advmod indirectly,signaling
R2810 T5723 T5709 prep with,block
R2811 T5752 T5742 prep by,signaling
R2812 T5753 T5752 pcomp downregulating,by
R2813 T5754 T5755 det the,function
R2814 T5724 T5725 amod high,avidity
R2815 T5755 T5753 dobj function,downregulating
R2816 T5756 T5755 prep of,function
R2817 T5757 T5758 amod antigen-presenting,cells
R2818 T5725 T5726 compound avidity,[
R2819 T5758 T5756 pobj cells,of
R2820 T5759 T5732 punct .,blocks
R2821 T5760 T5761 aux To,elucidate
R2822 T5726 T5723 pobj [,with
R2823 T5761 T5777 advcl elucidate,investigated
R2824 T5727 T5728 nummod 23,]
R2825 T5762 T5763 det the,resistance
R2826 T5728 T5726 appos ],[
R2827 T5763 T5761 dobj resistance,elucidate
R2828 T5764 T5763 prep of,resistance
R2829 T5806 T5805 prep of,expression
R2830 T5765 T5768 nummod CD4,cells
R2831 T5766 T5768 nummod +,cells
R2832 T5767 T5768 compound T,cells
R2833 T5768 T5764 pobj cells,of
R2834 T5769 T5761 prep to,elucidate
R2835 T5807 T5806 pobj SOCS1,of
R2836 T5770 T5772 det this,inhibition
R2837 T5771 T5772 amod direct,inhibition
R2838 T5772 T5769 pobj inhibition,to
R2839 T5773 T5772 prep in,inhibition
R2840 T5808 T5807 cc and,SOCS1
R2841 T5774 T5773 pobj RA,in
R2842 T5775 T5777 punct ",",investigated
R2843 T5776 T5777 nsubj we,investigated
R2844 T5777 T5777 ROOT investigated,investigated
R2845 T5778 T5779 det the,production
R2846 T5779 T5777 dobj production,investigated
R2847 T5809 T5807 conj SOCS3,SOCS1
R2848 T5780 T5779 prep of,production
R2849 T5781 T5780 pobj IFN-γ,of
R2850 T5782 T5777 prep after,investigated
R2851 T5810 T5805 appos mRNA,expression
R2852 T5783 T5786 nsubj CD3,costimulation
R2853 T5784 T5783 cc and,CD3
R2854 T5785 T5783 conj CD28,CD3
R2855 T5786 T5782 pobj costimulation,after
R2856 T5811 T5799 prep in,phosphorylation
R2857 T5787 T5786 prep in,costimulation
R2858 T5788 T5789 det the,presence
R2859 T5812 T5813 amod peripheral,blood
R2860 T5789 T5787 pobj presence,in
R2861 T5790 T5789 prep of,presence
R2862 T5791 T5790 pobj IL-10,of
R2863 T5792 T5791 punct ",",IL-10
R2864 T5813 T5811 pobj blood,in
R2865 T5793 T5794 det the,induction
R2866 T5794 T5791 appos induction,IL-10
R2867 T5814 T5815 punct (,PB
R2868 T5795 T5794 prep of,induction
R2869 T5796 T5795 pobj STAT1,of
R2870 T5797 T5796 cc and,STAT1
R2871 T5815 T5791 appos PB,IL-10
R2872 T5798 T5799 nummod STAT3,phosphorylation
R2873 T5799 T5796 conj phosphorylation,STAT1
R2874 T5800 T5799 prep by,phosphorylation
R2875 T5816 T5815 punct ),PB
R2876 T5801 T5800 pobj IL-10,by
R2877 T5802 T5799 punct ",",phosphorylation
R2878 T5803 T5799 cc and,phosphorylation
R2879 T5817 T5820 nsubj CD4,cells
R2880 T5804 T5805 det the,expression
R2881 T5805 T5799 conj expression,phosphorylation
R2882 T5818 T5820 nummod +,cells
R2883 T5819 T5820 compound T,cells
R2884 T5820 T5820 ROOT cells,cells
R2885 T5821 T5820 prep from,cells
R2887 T5822 T5823 compound RA,patients
R2889 T5823 T5821 pobj patients,from
R2894 T5824 T5820 punct .,cells
R3398 T7081 T7081 ROOT Patients,Patients
R3399 T7082 T7081 cc and,Patients
R3400 T7083 T7081 conj samples,Patients
R3401 T7084 T7087 det The,population
R3402 T7085 T7087 amod total,population
R3403 T7086 T7087 amod patient,population
R3404 T7087 T7088 nsubj population,consisted
R3405 T7088 T7101 ccomp consisted,mean
R3406 T7089 T7088 prep of,consisted
R3407 T7090 T7091 nummod 32,patients
R3408 T7091 T7089 pobj patients,of
R3409 T7092 T7091 prep with,patients
R3410 T7093 T7092 pobj RA,with
R3411 T7094 T7093 punct (,RA
R3412 T7095 T7096 nummod 25,women
R3413 T7096 T7093 appos women,RA
R3414 T7097 T7096 cc and,women
R3415 T7098 T7099 nummod seven,men
R3416 T7099 T7096 conj men,women
R3417 T7100 T7101 punct ;,mean
R3418 T7101 T7101 ROOT mean,mean
R3419 T7102 T7105 amod ±,age
R3420 T7103 T7104 amod standard,deviation
R3421 T7104 T7105 compound deviation,age
R3422 T7105 T7101 dobj age,mean
R3423 T7106 T7105 punct ",",age
R3424 T7107 T7108 nummod 52.8,±
R3425 T7108 T7105 appos ±,age
R3426 T7109 T7110 nummod 12.4,years
R3427 T7110 T7108 appos years,±
R3428 T7111 T7105 punct ),age
R3429 T7112 T7105 acl diagnosed,age
R3430 T7113 T7112 prep according,diagnosed
R3431 T7114 T7113 prep to,according
R3432 T7115 T7118 det the,criteria
R3433 T7116 T7118 amod revised,criteria
R3434 T7117 T7118 nummod 1987,criteria
R3435 T7118 T7114 pobj criteria,to
R3436 T7119 T7118 prep of,criteria
R3437 T7120 T7122 det the,College
R3438 T7121 T7122 compound American,College
R3439 T7122 T7119 pobj College,of
R3440 T7123 T7122 prep of,College
R3441 T7124 T7123 pobj Rheumatology,of
R3442 T7125 T7131 punct (,Association
R3443 T7126 T7131 advmod formally,Association
R3444 T7127 T7131 punct ",",Association
R3445 T7128 T7131 det the,Association
R3446 T7129 T7131 compound American,Association
R3447 T7130 T7131 compound Rheumatism,Association
R3448 T7131 T7122 appos Association,College
R3449 T7132 T7133 punct ),[
R3450 T7133 T7135 nmod [,]
R3451 T7134 T7135 nummod 25,]
R3452 T7135 T7131 appos ],Association
R3453 T7136 T7101 punct .,mean
R3454 T7137 T7138 det All,patients
R3455 T7138 T7140 nsubj patients,receiving
R3456 T7139 T7140 aux were,receiving
R3457 T7140 T7140 ROOT receiving,receiving
R3458 T7141 T7140 dobj prednisolone,receiving
R3459 T7142 T7141 punct (,prednisolone
R3460 T7143 T7141 appos ≤,prednisolone
R3461 T7144 T7145 nummod 7.5,mg/day
R3462 T7145 T7143 appos mg/day,≤
R3463 T7146 T7145 punct ),mg/day
R3464 T7147 T7145 cc and,mg/day
R3465 T7148 T7150 amod disease-modifying,drugs
R3466 T7149 T7150 amod antirheumatic,drugs
R3467 T7150 T7145 conj drugs,mg/day
R3468 T7151 T7140 punct .,receiving
R3469 T7152 T7153 amod Clinical,parameters
R3470 T7153 T7158 nsubj parameters,were
R3471 T7154 T7153 prep in,parameters
R3472 T7155 T7157 det the,patients
R3473 T7156 T7157 compound study,patients
R3474 T7157 T7154 pobj patients,in
R3475 T7158 T7158 ROOT were,were
R3476 T7159 T7160 mark as,follows
R3477 T7160 T7158 advcl follows,were
R3478 T7161 T7162 punct (,mean
R3479 T7162 T7170 meta mean,rate
R3480 T7163 T7165 nmod ±,deviation
R3481 T7164 T7165 amod standard,deviation
R3482 T7165 T7162 dobj deviation,mean
R3483 T7166 T7162 punct ),mean
R3484 T7167 T7162 punct :,mean
R3485 T7168 T7170 compound erythrocyte,rate
R3486 T7169 T7170 compound sedimentation,rate
R3487 T7170 T7160 nsubj rate,follows
R3488 T7171 T7170 punct ",",rate
R3489 T7172 T7175 nummod 55.9,mm/hour
R3490 T7173 T7175 nmod ±,mm/hour
R3491 T7174 T7175 nummod 35.4,mm/hour
R3492 T7175 T7170 appos mm/hour,rate
R3493 T7176 T7170 punct ;,rate
R3494 T7177 T7179 nmod serum,protein
R3495 T7178 T7179 amod C-reactive,protein
R3496 T7179 T7170 appos protein,rate
R3497 T7180 T7181 punct (,CRP
R3498 T7181 T7179 appos CRP,protein
R3499 T7182 T7181 punct ),CRP
R3500 T7183 T7179 appos level,protein
R3501 T7184 T7179 punct ",",protein
R3502 T7185 T7188 nummod 32.0,mg/l
R3503 T7186 T7188 nummod ±,mg/l
R3504 T7187 T7188 nummod 32.0,mg/l
R3505 T7188 T7179 appos mg/l,protein
R3506 T7189 T7170 punct ;,rate
R3507 T7190 T7170 cc and,rate
R3508 T7191 T7192 compound IgM,class
R3509 T7192 T7194 compound class,factor
R3510 T7193 T7194 compound rheumatoid,factor
R3511 T7194 T7195 compound factor,titer
R3512 T7195 T7170 conj titer,rate
R3513 T7196 T7195 punct ",",titer
R3514 T7197 T7199 quantmod 142,158
R3515 T7198 T7199 quantmod ±,158
R3516 T7199 T7200 nummod 158,U/ml
R3517 T7200 T7170 conj U/ml,rate
R3518 T7201 T7158 punct .,were
R3519 T7202 T7204 nsubjpass Patients,divided
R3520 T7203 T7204 auxpass were,divided
R3521 T7204 T7204 ROOT divided,divided
R3522 T7205 T7204 prep into,divided
R3523 T7206 T7207 nummod two,groups
R3524 T7207 T7205 pobj groups,into
R3525 T7208 T7207 punct :,groups
R3526 T7209 T7210 nummod 24,patients
R3527 T7210 T7207 appos patients,groups
R3528 T7211 T7210 prep with,patients
R3529 T7212 T7213 amod active,disease
R3530 T7213 T7211 pobj disease,with
R3531 T7214 T7213 punct ",",disease
R3532 T7215 T7216 nsubj who,had
R3533 T7216 T7213 relcl had,disease
R3534 T7217 T7218 amod multiple,tender
R3535 T7218 T7216 dobj tender,had
R3536 T7219 T7218 cc and/or,tender
R3537 T7220 T7221 amod swollen,joints
R3538 T7221 T7218 conj joints,tender
R3539 T7222 T7221 cc and,joints
R3540 T7223 T7224 amod elevated,serum
R3541 T7224 T7221 conj serum,joints
R3542 T7225 T7226 compound CRP,level
R3543 T7226 T7216 npadvmod level,had
R3544 T7227 T7228 punct (,≥
R3545 T7228 T7230 nmod ≥,mg/l
R3546 T7229 T7230 nummod 10,mg/l
R3547 T7230 T7226 appos mg/l,level
R3548 T7231 T7226 punct ),level
R3549 T7232 T7216 punct ;,had
R3550 T7233 T7210 cc and,patients
R3551 T7234 T7235 nummod eight,patients
R3552 T7235 T7210 conj patients,patients
R3553 T7236 T7235 prep with,patients
R3554 T7237 T7238 amod inactive,disease
R3555 T7238 T7236 pobj disease,with
R3556 T7239 T7238 punct ",",disease
R3557 T7240 T7241 nsubj who,satisfied
R3558 T7241 T7210 relcl satisfied,patients
R3559 T7242 T7244 det the,College
R3560 T7243 T7244 compound American,College
R3561 T7244 T7241 dobj College,satisfied
R3562 T7245 T7244 prep of,College
R3563 T7246 T7248 amod Rheumatology,criteria
R3564 T7247 T7248 amod preliminary,criteria
R3565 T7248 T7245 pobj criteria,of
R3566 T7249 T7248 prep for,criteria
R3567 T7250 T7251 amod clinical,remission
R3568 T7251 T7249 pobj remission,for
R3569 T7252 T7254 nmod [,]
R3570 T7253 T7254 nummod 26,]
R3571 T7254 T7244 appos ],College
R3572 T7255 T7204 punct .,divided
R3573 T7256 T7258 nummod Sixteen,volunteers
R3574 T7257 T7258 amod healthy,volunteers
R3575 T7258 T7273 nsubj volunteers,served
R3576 T7259 T7258 punct (,volunteers
R3577 T7260 T7261 nummod 11,women
R3578 T7261 T7258 appos women,volunteers
R3579 T7262 T7261 cc and,women
R3580 T7263 T7264 nummod five,men
R3581 T7264 T7261 conj men,women
R3582 T7265 T7258 punct ;,volunteers
R3583 T7266 T7258 appos age,volunteers
R3584 T7267 T7266 punct ",",age
R3585 T7268 T7269 nummod 45.8,±
R3586 T7269 T7266 appos ±,age
R3587 T7270 T7271 nummod 11.2,years
R3588 T7271 T7269 appos years,±
R3589 T7272 T7258 punct ),volunteers
R3590 T7273 T7273 ROOT served,served
R3591 T7274 T7273 prep as,served
R3592 T7275 T7274 pobj controls,as
R3593 T7276 T7273 punct .,served
R3594 T7277 T7278 compound ST,samples
R3595 T7278 T7280 nsubjpass samples,obtained
R3596 T7279 T7280 auxpass were,obtained
R3597 T7280 T7280 ROOT obtained,obtained
R3598 T7281 T7280 prep from,obtained
R3599 T7282 T7284 nummod three,patients
R3600 T7283 T7284 compound RA,patients
R3601 T7284 T7281 pobj patients,from
R3602 T7285 T7284 acl undergoing,patients
R3603 T7286 T7288 amod total,replacement
R3604 T7287 T7288 compound knee,replacement
R3605 T7288 T7285 dobj replacement,undergoing
R3606 T7289 T7280 punct .,obtained
R3607 T7290 T7291 det All,patients
R3608 T7291 T7292 nsubj patients,gave
R3609 T7292 T7292 ROOT gave,gave
R3610 T7293 T7294 amod informed,consent
R3611 T7294 T7292 dobj consent,gave
R3612 T7295 T7292 punct .,gave
R367 T1564 T1563 pobj CD4,in
R368 T1565 T1567 nummod +,cells
R369 T1566 T1567 compound T,cells
R370 T1567 T1561 dobj cells,signaling
R371 T1568 T1567 prep from,cells
R372 T1569 T1568 pobj patients,from
R373 T1600 T1599 prep from,cells
R374 T1601 T1600 pobj patients,from
R375 T1602 T1601 prep with,patients
R376 T1603 T1605 amod active,arthritis
R377 T1604 T1605 amod rheumatoid,arthritis
R378 T1605 T1602 pobj arthritis,with
R379 T1606 T1605 punct (,arthritis
R380 T1607 T1605 appos RA,arthritis
R3808 T7707 T7721 nsubjpass Isolation,prepared
R3809 T7708 T7707 prep of,Isolation
R381 T1608 T1605 punct ),arthritis
R3810 T7709 T7712 nummod CD4,cells
R3811 T7710 T7712 nummod +,cells
R3812 T7711 T7712 compound T,cells
R3813 T7712 T7708 pobj cells,of
R3814 T7713 T7716 amod Peripheral,cells
R3815 T7714 T7716 compound blood,cells
R3816 T7715 T7716 compound mononuclear,cells
R3817 T7716 T7712 appos cells,cells
R3818 T7717 T7718 punct (,PBMC
R3819 T7718 T7716 appos PBMC,cells
R382 T1609 T1592 ccomp were,found
R3820 T7719 T7716 punct ),cells
R3821 T7720 T7721 auxpass were,prepared
R3822 T7721 T7721 ROOT prepared,prepared
R3823 T7722 T7721 prep from,prepared
R3824 T7723 T7725 amod heparinized,samples
R3825 T7724 T7725 compound blood,samples
R3826 T7725 T7722 pobj samples,from
R3827 T7726 T7721 agent by,prepared
R3828 T7727 T7726 pobj centrifugation,by
R3829 T7728 T7727 prep over,centrifugation
R383 T1610 T1609 acomp able,were
R3830 T7729 T7730 amod Ficoll-Hypaque,density
R3831 T7730 T7731 compound density,gradients
R3832 T7731 T7728 pobj gradients,over
R3833 T7732 T7738 punct (,)
R3834 T7733 T7738 nmod Pharmacia,)
R3835 T7734 T7733 punct ",",Pharmacia
R3836 T7735 T7733 conj Uppsala,Pharmacia
R3837 T7736 T7735 punct ",",Uppsala
R3838 T7737 T7735 conj Sweden,Uppsala
R3839 T7738 T7727 punct ),centrifugation
R384 T1611 T1612 aux to,produce
R3840 T7739 T7721 punct .,prepared
R3841 T7740 T7743 nummod CD4,cells
R3842 T7741 T7743 nummod +,cells
R3843 T7742 T7743 compound T,cells
R3844 T7743 T7745 nsubjpass cells,purified
R3845 T7744 T7745 auxpass were,purified
R3846 T7745 T7745 ROOT purified,purified
R3847 T7746 T7745 prep from,purified
R3848 T7747 T7746 pobj PBMC,from
R3849 T7748 T7745 agent by,purified
R385 T1612 T1610 xcomp produce,able
R3850 T7749 T7750 amod positive,selection
R3851 T7750 T7748 pobj selection,by
R3852 T7751 T7745 advcl using,purified
R3853 T7752 T7755 amod anti-CD4,beads
R3854 T7753 T7755 amod mAb-coated,beads
R3855 T7754 T7755 amod magnetic,beads
R3856 T7755 T7751 dobj beads,using
R3857 T7756 T7755 punct (,beads
R3858 T7757 T7758 compound Miltenyi,Biotec
R3859 T7758 T7755 appos Biotec,beads
R386 T1613 T1614 amod greater,amounts
R3860 T7759 T7758 punct ",",Biotec
R3861 T7760 T7758 conj Gladbach,Biotec
R3862 T7761 T7760 punct ",",Gladbach
R3863 T7762 T7760 conj Germany,Gladbach
R3864 T7763 T7755 punct ),beads
R3865 T7764 T7745 punct ",",purified
R3866 T7765 T7745 prep according,purified
R3867 T7766 T7765 prep to,according
R3868 T7767 T7768 det the,manufacturer
R3869 T7768 T7770 poss manufacturer,instructions
R387 T1614 T1612 dobj amounts,produce
R3870 T7769 T7768 case 's,manufacturer
R3871 T7770 T7766 pobj instructions,to
R3872 T7771 T7745 punct .,purified
R3873 T7772 T7775 nummod CD4,cells
R3874 T7773 T7775 nummod +,cells
R3875 T7774 T7775 compound T,cells
R3876 T7775 T7777 nsubjpass cells,isolated
R3877 T7776 T7777 auxpass were,isolated
R3878 T7777 T7777 ROOT isolated,isolated
R3879 T7778 T7777 prep from,isolated
R388 T1615 T1614 prep of,amounts
R3880 T7779 T7780 compound ST,samples
R3881 T7780 T7778 pobj samples,from
R3882 T7781 T7777 punct ",",isolated
R3883 T7782 T7784 mark as,described
R3884 T7783 T7784 advmod previously,described
R3885 T7784 T7777 advcl described,isolated
R3886 T7785 T7787 nmod [,]
R3887 T7786 T7787 nummod 27,]
R3888 T7787 T7784 dobj ],described
R3889 T7788 T7777 punct .,isolated
R389 T1616 T1615 pobj interferon,of
R3890 T7789 T7795 advmod Briefly,fragmented
R3891 T7790 T7795 punct ",",fragmented
R3892 T7791 T7793 amod fresh,samples
R3893 T7792 T7793 compound ST,samples
R3894 T7793 T7795 nsubjpass samples,fragmented
R3895 T7794 T7795 auxpass were,fragmented
R3896 T7795 T7795 ROOT fragmented,fragmented
R3897 T7796 T7795 cc and,fragmented
R3898 T7797 T7795 conj digested,fragmented
R3899 T7798 T7797 prep with,digested
R390 T1617 T1614 acl gamma,amounts
R3900 T7799 T7798 pobj collagenase,with
R3901 T7800 T7799 cc and,collagenase
R3902 T7801 T7799 conj DNase,collagenase
R3903 T7802 T7797 prep for,digested
R3904 T7803 T7804 nummod 1,hour
R3905 T7804 T7802 pobj hour,for
R3906 T7805 T7797 prep at,digested
R3907 T7806 T7807 nummod 37,°
R3908 T7807 T7805 pobj °,at
R3909 T7808 T7805 pobj C,at
R391 T1618 T1617 prep after,gamma
R3910 T7809 T7795 punct .,fragmented
R3911 T7810 T7817 prep After,suspensions
R3912 T7811 T7810 pcomp removing,After
R3913 T7812 T7813 compound tissue,debris
R3914 T7813 T7811 dobj debris,removing
R3915 T7814 T7817 punct ",",suspensions
R3916 T7815 T7817 compound ST,suspensions
R3917 T7816 T7817 compound cell,suspensions
R3918 T7817 T7835 ccomp suspensions,supplemented
R3919 T7818 T7817 prep in,suspensions
R392 T1619 T1618 pobj CD3,after
R3920 T7819 T7820 compound culture,medium
R3921 T7820 T7818 pobj medium,in
R3922 T7821 T7824 punct (,medium
R3923 T7822 T7824 nmod RPMI,medium
R3924 T7823 T7822 nummod 1640,RPMI
R3925 T7824 T7817 appos medium,suspensions
R3926 T7825 T7835 punct ;,supplemented
R3927 T7826 T7827 compound Life,Technologies
R3928 T7827 T7835 nsubj Technologies,supplemented
R3929 T7828 T7827 punct ",",Technologies
R393 T1620 T1619 cc and,CD3
R3930 T7829 T7827 conj Gaithersburg,Technologies
R3931 T7830 T7829 punct ",",Gaithersburg
R3932 T7831 T7829 conj MD,Gaithersburg
R3933 T7832 T7831 punct ",",MD
R3934 T7833 T7831 conj USA,MD
R3935 T7834 T7827 punct ),Technologies
R3936 T7835 T7835 ROOT supplemented,supplemented
R3937 T7836 T7835 prep with,supplemented
R3938 T7837 T7839 nummod 25,HEPES
R3939 T7838 T7839 compound mM,HEPES
R394 T1621 T1622 compound CD28,costimulation
R3940 T7839 T7849 nmod HEPES,acids
R3941 T7840 T7843 punct (,L-glutamine
R3942 T7841 T7843 nummod 2,L-glutamine
R3943 T7842 T7843 compound mM,L-glutamine
R3944 T7843 T7839 appos L-glutamine,HEPES
R3945 T7844 T7843 punct ",",L-glutamine
R3946 T7845 T7846 nummod 2,%
R3947 T7846 T7849 nmod %,acids
R3948 T7847 T7849 amod nonessential,acids
R3949 T7848 T7849 amod amino,acids
R395 T1622 T1619 conj costimulation,CD3
R3950 T7849 T7836 pobj acids,with
R3951 T7850 T7849 punct ",",acids
R3952 T7851 T7853 nummod 100,penicillin
R3953 T7852 T7853 compound IU/ml,penicillin
R3954 T7853 T7849 conj penicillin,acids
R3955 T7854 T7853 punct ",",penicillin
R3956 T7855 T7853 cc and,penicillin
R3957 T7856 T7858 nummod 100,streptomycin
R3958 T7857 T7858 amod mg/ml,streptomycin
R3959 T7858 T7853 conj streptomycin,penicillin
R396 T1623 T1622 prep in,costimulation
R3960 T7859 T7861 punct ;,Technologies
R3961 T7860 T7861 compound Life,Technologies
R3962 T7861 T7835 npadvmod Technologies,supplemented
R3963 T7862 T7861 punct ),Technologies
R3964 T7863 T7861 prep with,Technologies
R3965 T7864 T7865 nummod 10,%
R3966 T7865 T7863 pobj %,with
R3967 T7866 T7867 amod heat-inactivated,FCS
R3968 T7867 T7873 nsubjpass FCS,incubated
R3969 T7868 T7870 punct (,Technologies
R397 T1624 T1625 det the,presence
R3970 T7869 T7870 compound Life,Technologies
R3971 T7870 T7867 appos Technologies,FCS
R3972 T7871 T7870 punct ),Technologies
R3973 T7872 T7873 auxpass were,incubated
R3974 T7873 T7873 ROOT incubated,incubated
R3975 T7874 T7873 prep at,incubated
R3976 T7875 T7876 nummod 37,°
R3977 T7876 T7877 nummod °,C
R3978 T7877 T7874 pobj C,at
R3979 T7878 T7877 prep in,C
R398 T1625 T1623 pobj presence,in
R3980 T7879 T7880 amod six-well,plates
R3981 T7880 T7878 pobj plates,in
R3982 T7881 T7877 punct (,C
R3983 T7882 T7877 appos Coster,C
R3984 T7883 T7882 punct ",",Coster
R3985 T7884 T7882 npadvmod Cambridge,Coster
R3986 T7885 T7884 punct ",",Cambridge
R3987 T7886 T7884 conj MA,Cambridge
R3988 T7887 T7886 punct ",",MA
R3989 T7888 T7886 npadvmod USA,MA
R399 T1626 T1625 prep of,presence
R3990 T7889 T7886 punct ),MA
R3991 T7890 T7884 prep for,Cambridge
R3992 T7891 T7892 nummod 45,min
R3993 T7892 T7890 pobj min,for
R3994 T7893 T7882 punct .,Coster
R3995 T7894 T7895 amod Non-adherent,cells
R3996 T7895 T7897 nsubjpass cells,harvested
R3997 T7896 T7897 auxpass were,harvested
R3998 T7897 T7897 ROOT harvested,harvested
R3999 T7898 T7897 cc and,harvested
R400 T1627 T1629 nummod 1,IL-10
R4000 T7899 T7902 compound CD4,cells
R4001 T7900 T7902 nummod +,cells
R4002 T7901 T7902 compound T,cells
R4003 T7902 T7904 nsubjpass cells,purified
R4004 T7903 T7904 auxpass were,purified
R4005 T7904 T7897 conj purified,harvested
R4006 T7905 T7904 agent by,purified
R4007 T7906 T7907 amod positive,selection
R4008 T7907 T7905 pobj selection,by
R4009 T7908 T7910 mark as,described
R401 T1628 T1629 compound ng/ml,IL-10
R4010 T7909 T7910 advmod already,described
R4011 T7910 T7904 advcl described,purified
R4012 T7911 T7904 punct .,purified
R402 T1629 T1626 pobj IL-10,of
R403 T1630 T1631 mark than,were
R404 T1631 T1614 advcl were,amounts
R405 T1632 T1633 amod normal,control
R406 T1633 T1631 attr control,were
R407 T1634 T1637 compound CD4,cells
R408 T1635 T1637 compound +,cells
R409 T1636 T1637 compound T,cells
R410 T1637 T1631 nsubj cells,were
R411 T1638 T1631 punct ",",were
R412 T1639 T1650 mark although,increased
R413 T1640 T1642 poss their,expression
R414 T1641 T1642 compound surface,expression
R415 T1642 T1650 nsubjpass expression,increased
R416 T1643 T1642 prep of,expression
R417 T1644 T1645 det the,type
R418 T1645 T1648 nmod type,receptor
R419 T1646 T1647 nummod 1,IL-10
R420 T1647 T1648 compound IL-10,receptor
R421 T1648 T1643 pobj receptor,of
R4212 T8313 T8318 nmod Culture,cells
R4213 T8314 T8313 prep of,Culture
R4214 T8315 T8314 pobj CD4,of
R4215 T8316 T8313 conj +,Culture
R4216 T8317 T8318 compound T,cells
R4217 T8318 T8325 nsubjpass cells,resuspended
R4218 T8319 T8323 compound PB,populations
R4219 T8320 T8323 compound CD4,populations
R422 T1649 T1650 auxpass was,increased
R4220 T8321 T8323 compound +,populations
R4221 T8322 T8323 compound T-cell,populations
R4222 T8323 T8325 nsubjpass populations,resuspended
R4223 T8324 T8325 auxpass were,resuspended
R4224 T8325 T8325 ROOT resuspended,resuspended
R4225 T8326 T8325 prep at,resuspended
R4226 T8327 T8328 det a,density
R4227 T8328 T8326 pobj density,at
R4228 T8329 T8328 prep of,density
R4229 T8330 T8333 nummod 1,cells/ml
R423 T1650 T1609 advcl increased,were
R4230 T8331 T8333 nummod ×,cells/ml
R4231 T8332 T8333 nummod 106,cells/ml
R4232 T8333 T8329 pobj cells/ml,of
R4233 T8334 T8333 prep in,cells/ml
R4234 T8335 T8336 compound culture,medium
R4235 T8336 T8334 pobj medium,in
R4236 T8337 T8325 prep with,resuspended
R4237 T8338 T8339 nummod 10,%
R4238 T8339 T8340 compound %,FCS
R4239 T8340 T8337 pobj FCS,with
R424 T1651 T1592 punct .,found
R4240 T8341 T8325 punct ",",resuspended
R4241 T8342 T8325 cc and,resuspended
R4242 T8343 T8346 nummod 0.5,suspensions
R4243 T8344 T8346 compound ml,suspensions
R4244 T8345 T8346 compound cell,suspensions
R4245 T8346 T8348 nsubjpass suspensions,dispensed
R4246 T8347 T8348 auxpass were,dispensed
R4247 T8348 T8325 conj dispensed,resuspended
R4248 T8349 T8348 prep into,dispensed
R4249 T8350 T8351 det the,wells
R425 T1652 T1653 det The,phosphorylation
R4250 T8351 T8349 pobj wells,into
R4251 T8352 T8351 prep of,wells
R4252 T8353 T8355 amod 24-well,plates
R4253 T8354 T8355 compound microtiter,plates
R4254 T8355 T8352 pobj plates,of
R4255 T8356 T8357 punct (,Coster
R4256 T8357 T8351 appos Coster,wells
R4257 T8358 T8351 punct ),wells
R4258 T8359 T8348 conj coated,dispensed
R4259 T8360 T8359 prep with,coated
R426 T1653 T1663 nsubjpass phosphorylation,sustained
R4260 T8361 T8362 nummod 1,μg
R4261 T8362 T8360 pobj μg,with
R4262 T8363 T8364 compound /,ml
R4263 T8364 T8366 compound ml,mAb
R4264 T8365 T8366 compound anti-CD3,mAb
R4265 T8366 T8362 appos mAb,μg
R4266 T8367 T8368 punct (,Immunotech
R4267 T8368 T8366 appos Immunotech,mAb
R4268 T8369 T8368 punct ",",Immunotech
R4269 T8370 T8368 npadvmod Marseille,Immunotech
R427 T1654 T1653 prep of,phosphorylation
R4270 T8371 T8370 punct ",",Marseille
R4271 T8372 T8370 conj France,Marseille
R4272 T8373 T8368 punct ),Immunotech
R4273 T8374 T8348 punct .,dispensed
R4274 T8375 T8376 det The,cells
R4275 T8376 T8378 nsubjpass cells,incubated
R4276 T8377 T8378 auxpass were,incubated
R4277 T8378 T8378 ROOT incubated,incubated
R4278 T8379 T8378 prep with,incubated
R4279 T8380 T8381 nummod 1,μg
R428 T1655 T1656 compound signal,transducer
R4280 T8381 T8385 compound μg,mAb
R4281 T8382 T8383 compound /,ml
R4282 T8383 T8385 compound ml,mAb
R4283 T8384 T8385 compound anti-CD28,mAb
R4284 T8385 T8379 pobj mAb,with
R4285 T8386 T8385 punct (,mAb
R4286 T8387 T8385 appos Immunotech,mAb
R4287 T8388 T8385 punct ),mAb
R4288 T8389 T8378 prep in,incubated
R4289 T8390 T8391 det the,presence
R429 T1656 T1654 pobj transducer,of
R4290 T8391 T8389 pobj presence,in
R4291 T8392 T8391 cc or,presence
R4292 T8393 T8391 conj absence,presence
R4293 T8394 T8393 prep of,absence
R4294 T8395 T8397 det the,concentrations
R4295 T8396 T8397 amod indicated,concentrations
R4296 T8397 T8394 pobj concentrations,of
R4297 T8398 T8397 prep of,concentrations
R4298 T8399 T8398 pobj IL-10,of
R4299 T8400 T8399 punct (,IL-10
R430 T1657 T1656 cc and,transducer
R4300 T8401 T8402 compound Becton,Dickinson
R4301 T8402 T8399 appos Dickinson,IL-10
R4302 T8403 T8402 punct ",",Dickinson
R4303 T8404 T8405 compound San,Jose
R4304 T8405 T8402 npadvmod Jose,Dickinson
R4305 T8406 T8405 punct ",",Jose
R4306 T8407 T8405 conj CA,Jose
R4307 T8408 T8407 punct ",",CA
R4308 T8409 T8399 appos USA,IL-10
R4309 T8410 T8399 punct ),IL-10
R431 T1658 T1656 conj activator,transducer
R4310 T8411 T8397 prep at,concentrations
R4311 T8412 T8413 nummod 37,°
R4312 T8413 T8414 nummod °,C
R4313 T8414 T8411 pobj C,at
R4314 T8415 T8397 prep in,concentrations
R4315 T8416 T8418 det a,atmosphere
R4316 T8417 T8418 amod humidified,atmosphere
R4317 T8418 T8415 pobj atmosphere,in
R4318 T8419 T8418 acl containing,atmosphere
R4319 T8420 T8421 nummod 5,%
R432 T1659 T1658 prep of,activator
R4320 T8421 T8419 dobj %,containing
R4321 T8422 T8425 nummod CO2,]
R4322 T8423 T8425 nmod [,]
R4323 T8424 T8425 nummod 28,]
R4324 T8425 T8418 appos ],atmosphere
R4325 T8426 T8378 punct .,incubated
R4326 T8427 T8428 compound Culture,supernatants
R4327 T8428 T8430 nsubjpass supernatants,collected
R4328 T8429 T8430 auxpass were,collected
R4329 T8430 T8430 ROOT collected,collected
R433 T1660 T1659 pobj transcription,of
R4330 T8431 T8432 nummod 36,hours
R4331 T8432 T8433 npadvmod hours,later
R4332 T8433 T8430 advmod later,collected
R4333 T8434 T8433 cc and,later
R4334 T8435 T8436 amod cell-free,samples
R4335 T8436 T8438 nsubjpass samples,stored
R4336 T8437 T8438 auxpass were,stored
R4337 T8438 T8430 conj stored,collected
R4338 T8439 T8438 prep at,stored
R4339 T8440 T8441 nummod -30,°
R434 T1661 T1660 nummod 3,transcription
R4340 T8441 T8439 pobj °,at
R4341 T8442 T8438 conj C,stored
R4342 T8443 T8442 prep until,C
R4343 T8444 T8445 compound cytokine,assay
R4344 T8445 T8443 pobj assay,until
R4345 T8446 T8438 punct .,stored
R4346 T8447 T8448 aux To,examine
R4347 T8448 T8467 advcl examine,incubated
R4348 T8449 T8450 det the,effect
R4349 T8450 T8448 dobj effect,examine
R435 T1662 T1663 auxpass was,sustained
R4350 T8451 T8450 prep of,effect
R4351 T8452 T8451 pobj IL-6,of
R4352 T8453 T8450 prep on,effect
R4353 T8454 T8455 compound T-cell,responsiveness
R4354 T8455 T8453 pobj responsiveness,on
R4355 T8456 T8455 prep to,responsiveness
R4356 T8457 T8456 pobj IL-10,to
R4357 T8458 T8457 punct ",",IL-10
R4358 T8459 T8462 compound CD4,cells
R4359 T8460 T8462 compound +,cells
R436 T1663 T1663 ROOT sustained,sustained
R4360 T8461 T8462 compound T,cells
R4361 T8462 T8455 conj cells,responsiveness
R4362 T8463 T8448 prep from,examine
R4363 T8464 T8465 amod healthy,controls
R4364 T8465 T8463 pobj controls,from
R4365 T8466 T8467 auxpass were,incubated
R4366 T8467 T8467 ROOT incubated,incubated
R4367 T8468 T8467 prep in,incubated
R4368 T8469 T8470 compound culture,medium
R4369 T8470 T8468 pobj medium,in
R437 T1664 T1663 prep in,sustained
R4370 T8471 T8467 prep with,incubated
R4371 T8472 T8473 nummod 10,%
R4372 T8473 T8474 compound %,FCS
R4373 T8474 T8471 pobj FCS,with
R4374 T8475 T8467 prep in,incubated
R4375 T8476 T8477 det the,presence
R4376 T8477 T8475 pobj presence,in
R4377 T8478 T8477 cc or,presence
R4378 T8479 T8477 conj absence,presence
R4379 T8480 T8479 prep of,absence
R438 T1665 T1666 det both,blood
R4380 T8481 T8483 nummod 10,IL-6
R4381 T8482 T8483 compound ng/ml,IL-6
R4382 T8483 T8480 pobj IL-6,of
R4383 T8484 T8486 punct (,Dickinson
R4384 T8485 T8486 compound Becton,Dickinson
R4385 T8486 T8483 appos Dickinson,IL-6
R4386 T8487 T8467 punct ),incubated
R4387 T8488 T8467 prep for,incubated
R4388 T8489 T8490 nummod 36,hours
R4389 T8490 T8488 pobj hours,for
R439 T1666 T1673 nmod blood,cells
R4390 T8491 T8467 punct .,incubated
R4391 T8492 T8495 nsubjpass Cells,stimulated
R4392 T8493 T8495 auxpass were,stimulated
R4393 T8494 T8495 advmod then,stimulated
R4394 T8495 T8495 ROOT stimulated,stimulated
R4395 T8496 T8495 prep for,stimulated
R4396 T8497 T8498 nummod 36,hours
R4397 T8498 T8496 pobj hours,for
R4398 T8499 T8495 prep with,stimulated
R4399 T8500 T8501 compound anti-CD3,mAb
R440 T1667 T1666 cc and,blood
R4400 T8501 T8499 pobj mAb,with
R4401 T8502 T8501 cc and,mAb
R4402 T8503 T8504 amod anti-CD28,mAb
R4403 T8504 T8501 conj mAb,mAb
R4404 T8505 T8504 prep in,mAb
R4405 T8506 T8507 det the,presence
R4406 T8507 T8505 pobj presence,in
R4407 T8508 T8507 cc or,presence
R4408 T8509 T8507 conj absence,presence
R4409 T8510 T8507 prep of,presence
R441 T1668 T1669 amod synovial,tissue
R4410 T8511 T8513 nummod 1,IL-10
R4411 T8512 T8513 compound ng/ml,IL-10
R4412 T8513 T8510 pobj IL-10,of
R4413 T8514 T8495 punct .,stimulated
R4414 T8515 T8516 compound Culture,supernatants
R4415 T8516 T8518 nsubjpass supernatants,measured
R4416 T8517 T8518 auxpass were,measured
R4417 T8518 T8518 ROOT measured,measured
R4418 T8519 T8518 prep for,measured
R4419 T8520 T8521 amod IFN-γ,concentrations
R442 T1669 T1666 conj tissue,blood
R4420 T8521 T8519 pobj concentrations,for
R4421 T8522 T8518 punct .,measured
R443 T1670 T1673 compound CD4,cells
R444 T1671 T1673 compound +,cells
R445 T1672 T1673 compound T,cells
R446 T1673 T1664 pobj cells,in
R447 T1674 T1673 prep of,cells
R448 T1675 T1674 pobj RA,of
R449 T1676 T1663 punct ",",sustained
R450 T1677 T1663 cc but,sustained
R451 T1678 T1681 nsubjpass it,augmented
R452 T1679 T1681 auxpass was,augmented
R453 T1680 T1681 neg not,augmented
R454 T1681 T1663 conj augmented,sustained
R4540 T8847 T8849 nmod Flow,analysis
R4541 T8848 T8849 amod cytometric,analysis
R4542 T8849 T8863 nsubjpass analysis,resuspended
R4543 T8850 T8849 prep for,analysis
R4544 T8851 T8852 compound IL-10R1,expression
R4545 T8852 T8850 pobj expression,for
R4546 T8853 T8854 det A,sample
R4547 T8854 T8863 nsubjpass sample,resuspended
R4548 T8855 T8854 prep of,sample
R4549 T8856 T8859 nummod 5,cells
R455 T1682 T1681 agent by,augmented
R4550 T8857 T8859 nummod ×,cells
R4551 T8858 T8859 nummod 105,cells
R4552 T8859 T8855 pobj cells,of
R4553 T8860 T8859 prep of,cells
R4554 T8861 T8860 pobj PBMC,of
R4555 T8862 T8863 auxpass was,resuspended
R4556 T8863 T8863 ROOT resuspended,resuspended
R4557 T8864 T8863 prep in,resuspended
R4558 T8865 T8864 pobj PBS,in
R4559 T8866 T8863 prep with,resuspended
R456 T1683 T1684 det the,presence
R4560 T8867 T8868 nummod 1,%
R4561 T8868 T8869 compound %,FCS
R4562 T8869 T8866 pobj FCS,with
R4563 T8870 T8863 punct .,resuspended
R4564 T8871 T8873 nsubjpass PBMC,incubated
R4565 T8872 T8873 auxpass were,incubated
R4566 T8873 T8884 ccomp incubated,systems
R4567 T8874 T8873 prep with,incubated
R4568 T8875 T8874 pcomp saturating,with
R4569 T8876 T8875 dobj concentrations,saturating
R457 T1684 T1682 pobj presence,by
R4570 T8877 T8876 prep of,concentrations
R4571 T8878 T8879 compound anti-IL-10R1,mAb
R4572 T8879 T8877 pobj mAb,of
R4573 T8880 T8881 punct (,IgG1
R4574 T8881 T8879 appos IgG1,mAb
R4575 T8882 T8884 punct ;,systems
R4576 T8883 T8884 compound R&D,systems
R4577 T8884 T8884 ROOT systems,systems
R4578 T8885 T8884 punct ",",systems
R4579 T8886 T8884 appos Minneapolis,systems
R458 T1685 T1684 prep of,presence
R4580 T8887 T8886 punct ",",Minneapolis
R4581 T8888 T8886 conj MN,Minneapolis
R4582 T8889 T8888 punct ",",MN
R4583 T8890 T8888 conj USA,MN
R4584 T8891 T8888 punct ),MN
R4585 T8892 T8884 cc or,systems
R4586 T8893 T8884 prep with,systems
R4587 T8894 T8895 amod isotype-matched,control
R4588 T8895 T8896 compound control,mAb
R4589 T8896 T8893 pobj mAb,with
R459 T1686 T1688 nummod 1,IL-10
R4590 T8897 T8898 punct (,Immunotech
R4591 T8898 T8896 appos Immunotech,mAb
R4592 T8899 T8898 punct ),Immunotech
R4593 T8900 T8901 punct ",",followed
R4594 T8901 T8896 acl followed,mAb
R4595 T8902 T8901 agent by,followed
R4596 T8903 T8902 pobj incubation,by
R4597 T8904 T8903 prep with,incubation
R4598 T8905 T8910 amod FITC-conjugated,antibody
R4599 T8906 T8910 nmod goat,antibody
R460 T1687 T1688 compound ng/ml,IL-10
R4600 T8907 T8910 nmod anti-mouse,antibody
R4601 T8908 T8910 nmod IgG1,antibody
R4602 T8909 T8910 compound polyclonal,antibody
R4603 T8910 T8904 pobj antibody,with
R4604 T8911 T8910 punct (,antibody
R4605 T8912 T8914 compound Santa,Biotechnologies
R4606 T8913 T8914 compound Cruz,Biotechnologies
R4607 T8914 T8910 appos Biotechnologies,antibody
R4608 T8915 T8914 punct ",",Biotechnologies
R4609 T8916 T8917 compound Santa,Cruz
R461 T1688 T1685 pobj IL-10,of
R4610 T8917 T8914 conj Cruz,Biotechnologies
R4611 T8918 T8917 punct ",",Cruz
R4612 T8919 T8917 conj CA,Cruz
R4613 T8920 T8919 punct ",",CA
R4614 T8921 T8919 conj USA,CA
R4615 T8922 T8910 punct ),antibody
R4616 T8923 T8884 punct .,systems
R4617 T8924 T8927 nsubjpass Cells,incubated
R4618 T8925 T8927 auxpass were,incubated
R4619 T8926 T8927 advmod then,incubated
R462 T1689 T1681 punct .,augmented
R4620 T8927 T8927 ROOT incubated,incubated
R4621 T8928 T8927 prep with,incubated
R4622 T8929 T8931 amod phycoerythrin-conjugated,mAb
R4623 T8930 T8931 compound anti-CD4,mAb
R4624 T8931 T8928 pobj mAb,with
R4625 T8932 T8931 punct (,mAb
R4626 T8933 T8934 compound Becton,Dickinson
R4627 T8934 T8931 appos Dickinson,mAb
R4628 T8935 T8931 punct ),mAb
R4629 T8936 T8927 punct .,incubated
R463 T1690 T1694 nsubj Sera,induced
R4630 T8937 T8939 nsubjpass Cells,washed
R4631 T8938 T8939 auxpass were,washed
R4632 T8939 T8939 ROOT washed,washed
R4633 T8940 T8939 advmod well,washed
R4634 T8941 T8939 prep with,washed
R4635 T8942 T8943 nummod 1,%
R4636 T8943 T8944 compound %,FCS/PBS
R4637 T8944 T8941 pobj FCS/PBS,with
R4638 T8945 T8944 prep between,FCS/PBS
R4639 T8946 T8945 pobj incubations,between
R464 T1691 T1690 prep from,Sera
R4640 T8947 T8939 punct .,washed
R4641 T8948 T8950 nsubjpass Analysis,performed
R4642 T8949 T8950 auxpass was,performed
R4643 T8950 T8950 ROOT performed,performed
R4644 T8951 T8950 prep on,performed
R4645 T8952 T8954 det a,flow
R4646 T8953 T8954 amod FACScan,flow
R4647 T8954 T8951 pobj flow,on
R4648 T8955 T8950 npadvmod cytometer,performed
R4649 T8956 T8958 punct (,Dickinson
R465 T1692 T1693 compound RA,patients
R4650 T8957 T8958 compound Becton,Dickinson
R4651 T8958 T8955 appos Dickinson,cytometer
R4652 T8959 T8955 punct ),cytometer
R4653 T8960 T8950 punct .,performed
R466 T1693 T1691 pobj patients,from
R467 T1694 T1694 ROOT induced,induced
R468 T1695 T1696 compound signal,transducer
R469 T1696 T1694 dobj transducer,induced
R470 T1697 T1696 cc and,transducer
R471 T1698 T1696 conj activator,transducer
R4715 T9185 T9204 nsubjpass Immunoassay,measured
R4716 T9186 T9185 prep for,Immunoassay
R4717 T9187 T9186 pobj IFN-γ,for
R4718 T9188 T9187 cc and,IFN-γ
R4719 T9189 T9187 conj IL-2,IFN-γ
R472 T1699 T1698 prep of,activator
R4720 T9190 T9186 pobj Concentrations,for
R4721 T9191 T9190 prep of,Concentrations
R4722 T9192 T9191 pobj IFN-γ,of
R4723 T9193 T9192 cc and,IFN-γ
R4724 T9194 T9192 conj IL-2,IFN-γ
R4725 T9195 T9185 prep in,Immunoassay
R4726 T9196 T9197 compound culture,supernatants
R4727 T9197 T9195 pobj supernatants,in
R4728 T9198 T9197 prep of,supernatants
R4729 T9199 T9202 compound CD4,cells
R473 T1700 T1699 pobj transcription,of
R4730 T9200 T9202 compound +,cells
R4731 T9201 T9202 compound T,cells
R4732 T9202 T9198 pobj cells,of
R4733 T9203 T9204 auxpass were,measured
R4734 T9204 T9204 ROOT measured,measured
R4735 T9205 T9204 prep in,measured
R4736 T9206 T9205 pobj duplicate,in
R4737 T9207 T9204 agent by,measured
R4738 T9208 T9210 det the,sandwich
R4739 T9209 T9210 amod quantitative,sandwich
R474 T1701 T1702 nummod 3,phosphorylation
R4740 T9210 T9211 compound sandwich,ELISA
R4741 T9211 T9207 pobj ELISA,by
R4742 T9212 T9211 acl using,ELISA
R4743 T9213 T9214 amod cytokine-specific,capture
R4744 T9214 T9212 dobj capture,using
R4745 T9215 T9214 prep with,capture
R4746 T9216 T9217 amod biotinylated,detection
R4747 T9217 T9218 compound detection,mAb
R4748 T9218 T9215 pobj mAb,with
R4749 T9219 T9218 cc and,mAb
R475 T1702 T1696 appos phosphorylation,transducer
R4750 T9220 T9222 amod recombinant,proteins
R4751 T9221 T9222 compound cytokine,proteins
R4752 T9222 T9218 conj proteins,mAb
R4753 T9223 T9222 punct (,proteins
R4754 T9224 T9225 advmod all,from
R4755 T9225 T9218 prep from,mAb
R4756 T9226 T9227 compound Becton,Dickinson
R4757 T9227 T9225 pobj Dickinson,from
R4758 T9228 T9218 punct ),mAb
R4759 T9229 T9204 punct ",",measured
R476 T1703 T1702 prep in,phosphorylation
R4760 T9230 T9204 prep according,measured
R4761 T9231 T9230 prep to,according
R4762 T9232 T9233 det the,manufacturer
R4763 T9233 T9235 poss manufacturer,protocol
R4764 T9234 T9233 case 's,manufacturer
R4765 T9235 T9231 pobj protocol,to
R4766 T9236 T9204 punct .,measured
R4767 T9237 T9239 det The,limits
R4768 T9238 T9239 compound detection,limits
R4769 T9239 T9244 nsubj limits,were
R477 T1704 T1708 amod normal,cells
R4770 T9240 T9239 prep for,limits
R4771 T9241 T9240 pobj IFN-γ,for
R4772 T9242 T9241 cc and,IFN-γ
R4773 T9243 T9241 conj IL-2,IFN-γ
R4774 T9244 T9244 ROOT were,were
R4775 T9245 T9246 nummod 15,pg/ml
R4776 T9246 T9244 attr pg/ml,were
R4777 T9247 T9244 punct .,were
R478 T1705 T1708 compound CD4,cells
R479 T1706 T1708 nummod +,cells
R480 T1707 T1708 compound T,cells
R481 T1708 T1703 pobj cells,in
R482 T1709 T1708 punct ",",cells
R483 T1710 T1713 nsubjpass which,abolished
R484 T1711 T1713 auxpass was,abolished
R485 T1712 T1713 advmod mostly,abolished
R486 T1713 T1702 relcl abolished,phosphorylation
R487 T1714 T1713 prep by,abolished
R488 T1715 T1714 pcomp neutralizing,by
R489 T1716 T1717 amod anti-IL-6,antibody
R490 T1717 T1715 dobj antibody,neutralizing
R491 T1718 T1694 punct .,induced
R492 T1719 T1728 nsubj Preincubation,reduced
R493 T1720 T1719 prep of,Preincubation
R494 T1721 T1725 amod normal,cells
R495 T1722 T1725 compound CD4,cells
R496 T1723 T1725 nummod +,cells
R497 T1724 T1725 compound T,cells
R498 T1725 T1720 pobj cells,of
R499 T1726 T1719 prep with,Preincubation
R500 T1727 T1726 pobj IL-6,with
R501 T1728 T1728 ROOT reduced,reduced
R502 T1729 T1730 amod IL-10-mediated,inhibition
R503 T1730 T1728 dobj inhibition,reduced
R504 T1731 T1730 prep of,inhibition
R505 T1732 T1734 compound interferon,production
R506 T1733 T1734 compound gamma,production
R507 T1734 T1731 pobj production,of
R508 T1735 T1728 punct .,reduced
R509 T1736 T1737 compound Blood,CD4
R510 T1737 T1738 nsubj CD4,+
R5108 T10126 T10136 nsubjpass Isolation,extracted
R5109 T10127 T10126 prep of,Isolation
R511 T1738 T1738 ROOT +,+
R5110 T10128 T10127 pobj mRNA,of
R5111 T10129 T10128 cc and,mRNA
R5112 T10130 T10134 amod real-time,RNA
R5113 T10131 T10134 compound PCR,RNA
R5114 T10132 T10134 compound Total,RNA
R5115 T10133 T10134 amod cellular,RNA
R5116 T10134 T10128 conj RNA,mRNA
R5117 T10135 T10136 auxpass was,extracted
R5118 T10136 T10136 ROOT extracted,extracted
R5119 T10137 T10136 prep from,extracted
R512 T1739 T1740 compound T,cells
R5120 T10138 T10139 compound PB,CD4
R5121 T10139 T10137 pobj CD4,from
R5122 T10140 T10136 advmod +,extracted
R5123 T10141 T10142 compound T,cells
R5124 T10142 T10140 dobj cells,+
R5125 T10143 T10140 advcl using,+
R5126 T10144 T10147 det an,kit
R5127 T10145 T10147 compound RNA,kit
R5128 T10146 T10147 compound isolation,kit
R5129 T10147 T10143 dobj kit,using
R513 T1740 T1738 dobj cells,+
R5130 T10148 T10147 punct (,kit
R5131 T10149 T10150 compound RNeasy,Mini
R5132 T10150 T10151 compound Mini,kit
R5133 T10151 T10147 appos kit,kit
R5134 T10152 T10147 punct ;,kit
R5135 T10153 T10147 appos Qiagen,kit
R5136 T10154 T10153 punct ",",Qiagen
R5137 T10155 T10153 conj Valencia,Qiagen
R5138 T10156 T10155 punct ",",Valencia
R5139 T10157 T10155 conj CA,Valencia
R514 T1741 T1738 prep from,+
R5140 T10158 T10157 punct ",",CA
R5141 T10159 T10157 conj USA,CA
R5142 T10160 T10157 punct ),CA
R5143 T10161 T10140 punct ",",+
R5144 T10162 T10140 prep according,+
R5145 T10163 T10162 prep to,according
R5146 T10164 T10165 det the,manufacturer
R5147 T10165 T10167 poss manufacturer,instructions
R5148 T10166 T10165 case 's,manufacturer
R5149 T10167 T10163 pobj instructions,to
R515 T1742 T1743 compound RA,patients
R5150 T10168 T10136 punct .,extracted
R5151 T10169 T10171 nsubjpass cDNA,synthesized
R5152 T10170 T10171 auxpass was,synthesized
R5153 T10171 T10171 ROOT synthesized,synthesized
R5154 T10172 T10171 prep from,synthesized
R5155 T10173 T10174 amod total,RNA
R5156 T10174 T10172 pobj RNA,from
R5157 T10175 T10174 prep with,RNA
R5158 T10176 T10179 compound Molony,virus
R5159 T10177 T10179 compound murine,virus
R516 T1743 T1741 pobj patients,from
R5160 T10178 T10179 compound leukemia,virus
R5161 T10179 T10175 pobj virus,with
R5162 T10180 T10171 prep reverse,synthesized
R5163 T10181 T10180 npadvmod transcriptase,reverse
R5164 T10182 T10184 punct (,Biochemical
R5165 T10183 T10184 compound US,Biochemical
R5166 T10184 T10181 appos Biochemical,transcriptase
R5167 T10185 T10184 punct ",",Biochemical
R5168 T10186 T10184 appos Cleveland,Biochemical
R5169 T10187 T10186 punct ",",Cleveland
R517 T1744 T1738 conj contained,+
R5170 T10188 T10186 conj OH,Cleveland
R5171 T10189 T10188 punct ",",OH
R5172 T10190 T10188 conj USA,OH
R5173 T10191 T10188 punct ),OH
R5174 T10192 T10188 cc and,OH
R5175 T10193 T10184 punct oligo,Biochemical
R5176 T10194 T10193 punct -,oligo
R5177 T10195 T10196 punct (,dT
R5178 T10196 T10199 nmod dT,primers
R5179 T10197 T10196 punct ),dT
R518 T1745 T1746 amod higher,levels
R5180 T10198 T10199 nummod 15,primers
R5181 T10199 T10184 appos primers,Biochemical
R5182 T10200 T10201 punct (,Promega
R5183 T10201 T10184 appos Promega,Biochemical
R5184 T10202 T10201 punct ",",Promega
R5185 T10203 T10201 conj Madison,Promega
R5186 T10204 T10203 punct ",",Madison
R5187 T10205 T10203 conj WI,Madison
R5188 T10206 T10205 punct ",",WI
R5189 T10207 T10205 conj USA,WI
R519 T1746 T1744 dobj levels,contained
R5190 T10208 T10201 punct ),Promega
R5191 T10209 T10171 punct .,synthesized
R5192 T10210 T10211 compound Real-time,PCR
R5193 T10211 T10213 nsubjpass PCR,performed
R5194 T10212 T10213 auxpass was,performed
R5195 T10213 T10213 ROOT performed,performed
R5196 T10214 T10213 prep with,performed
R5197 T10215 T10217 det the,Instrument
R5198 T10216 T10217 compound LightCycler,Instrument
R5199 T10217 T10214 pobj Instrument,with
R520 T1747 T1746 prep of,levels
R5200 T10218 T10217 punct (,Instrument
R5201 T10219 T10220 compound Roche,Diagnostics
R5202 T10220 T10217 conj Diagnostics,Instrument
R5203 T10221 T10220 punct ",",Diagnostics
R5204 T10222 T10220 conj Penzberg,Diagnostics
R5205 T10223 T10222 punct ",",Penzberg
R5206 T10224 T10222 appos Germany,Penzberg
R5207 T10225 T10222 punct ),Penzberg
R5208 T10226 T10213 prep in,performed
R5209 T10227 T10228 compound glass,capillaries
R521 T1748 T1747 pobj suppressor,of
R5210 T10228 T10226 pobj capillaries,in
R5211 T10229 T10213 punct .,performed
R5212 T10230 T10232 det The,mix
R5213 T10231 T10232 compound reaction,mix
R5214 T10232 T10260 nsubjpass mix,added
R5215 T10233 T10232 acl containing,mix
R5216 T10234 T10236 compound Taq,polymerase
R5217 T10235 T10236 compound DNA,polymerase
R5218 T10236 T10233 dobj polymerase,containing
R5219 T10237 T10236 cc and,polymerase
R522 T1749 T1748 prep of,suppressor
R5220 T10238 T10241 compound DNA,Green
R5221 T10239 T10241 compound double-strand-specific,Green
R5222 T10240 T10241 compound SYBR,Green
R5223 T10241 T10232 appos Green,mix
R5224 T10242 T10243 nsubj I,dye
R5225 T10243 T10232 relcl dye,mix
R5226 T10244 T10243 punct (,dye
R5227 T10245 T10246 compound Lightcycler,FastStart
R5228 T10246 T10250 compound FastStart,Green
R5229 T10247 T10250 compound DNA,Green
R523 T1750 T1749 pobj cytokine,of
R5230 T10248 T10250 compound Master,Green
R5231 T10249 T10250 compound SYBR,Green
R5232 T10250 T10260 nsubjpass Green,added
R5233 T10251 T10250 nmod I,Green
R5234 T10252 T10254 punct ;,Diagnostics
R5235 T10253 T10254 compound Roche,Diagnostics
R5236 T10254 T10250 appos Diagnostics,Green
R5237 T10255 T10254 punct ),Diagnostics
R5238 T10256 T10254 cc and,Diagnostics
R5239 T10257 T10258 amod specific,primers
R524 T1751 T1746 acl signaling,levels
R5240 T10258 T10254 conj primers,Diagnostics
R5241 T10259 T10260 auxpass were,added
R5242 T10260 T10260 ROOT added,added
R5243 T10261 T10260 prep to,added
R5244 T10262 T10263 compound cDNA,dilutions
R5245 T10263 T10261 pobj dilutions,to
R5246 T10264 T10260 punct .,added
R5247 T10265 T10267 det The,samples
R5248 T10266 T10267 compound cDNA,samples
R5249 T10267 T10269 nsubjpass samples,denatured
R525 T1752 T1755 nummod 1,levels
R5250 T10268 T10269 auxpass were,denatured
R5251 T10269 T10269 ROOT denatured,denatured
R5252 T10270 T10269 prep at,denatured
R5253 T10271 T10272 nummod 95,°
R5254 T10272 T10270 pobj °,at
R5255 T10273 T10269 conj C,denatured
R5256 T10274 T10273 prep for,C
R5257 T10275 T10276 nummod 10,min
R5258 T10276 T10274 pobj min,for
R5259 T10277 T10273 punct ",",C
R526 T1753 T1752 cc but,1
R5260 T10278 T10269 cc and,denatured
R5261 T10279 T10281 auxpass were,amplified
R5262 T10280 T10281 advmod then,amplified
R5263 T10281 T10269 conj amplified,denatured
R5264 T10282 T10281 prep for,amplified
R5265 T10283 T10287 preconj 40,at
R5266 T10284 T10285 nummod 50,cycles
R5267 T10285 T10283 appos cycles,40
R5268 T10286 T10287 punct :,at
R5269 T10287 T10281 prep at,amplified
R527 T1754 T1752 conj lower,1
R5270 T10288 T10290 nummod 95,C
R5271 T10289 T10290 nummod °,C
R5272 T10290 T10287 pobj C,at
R5273 T10291 T10290 punct (,C
R5274 T10292 T10293 nummod 10,s
R5275 T10293 T10290 appos s,C
R5276 T10294 T10290 punct ),C
R5277 T10295 T10290 punct ",",C
R5278 T10296 T10287 prep at,at
R5279 T10297 T10299 nummod 65,C
R528 T1755 T1751 dobj levels,signaling
R5280 T10298 T10299 nummod °,C
R5281 T10299 T10296 pobj C,at
R5282 T10300 T10299 punct (,C
R5283 T10301 T10302 nummod 15,s
R5284 T10302 T10299 appos s,C
R5285 T10303 T10299 punct ),C
R5286 T10304 T10287 punct ",",at
R5287 T10305 T10287 cc and,at
R5288 T10306 T10308 nummod 72,C
R5289 T10307 T10308 compound °,C
R529 T1756 T1755 prep of,levels
R5290 T10308 T10287 conj C,at
R5291 T10309 T10310 punct (,22
R5292 T10310 T10308 parataxis 22,C
R5293 T10311 T10308 appos s,C
R5294 T10312 T10308 punct ),C
R5295 T10313 T10308 prep for,C
R5296 T10314 T10313 pobj β-actin,for
R5297 T10315 T10343 quantmod ;,for
R5298 T10316 T10315 nmod at,;
R5299 T10317 T10319 nummod 95,C
R530 T1757 T1756 pobj suppressor,of
R5300 T10318 T10319 nummod °,C
R5301 T10319 T10316 pobj C,at
R5302 T10320 T10319 punct (,C
R5303 T10321 T10322 nummod 10,s
R5304 T10322 T10319 appos s,C
R5305 T10323 T10319 punct ),C
R5306 T10324 T10319 punct ",",C
R5307 T10325 T10316 prep at,at
R5308 T10326 T10328 nummod 62,C
R5309 T10327 T10328 nummod °,C
R531 T1758 T1757 prep of,suppressor
R5310 T10328 T10325 pobj C,at
R5311 T10329 T10328 punct (,C
R5312 T10330 T10331 nummod 15,s
R5313 T10331 T10328 appos s,C
R5314 T10332 T10328 punct ),C
R5315 T10333 T10316 punct ",",at
R5316 T10334 T10316 cc and,at
R5317 T10335 T10316 conj at,at
R5318 T10336 T10338 nummod 72,C
R5319 T10337 T10338 nummod °,C
R532 T1759 T1758 pobj cytokine,of
R5320 T10338 T10335 pobj C,at
R5321 T10339 T10338 punct (,C
R5322 T10340 T10341 nummod 10,s
R5323 T10341 T10338 appos s,C
R5324 T10342 T10338 punct ),C
R5325 T10343 T10281 prep for,amplified
R5326 T10344 T10343 pobj SOCS1,for
R5327 T10345 T10343 punct ;,for
R5328 T10346 T10343 cc and,for
R5329 T10347 T10343 conj at,for
R533 T1760 T1755 acl signaling,levels
R5330 T10348 T10350 nummod 96,C
R5331 T10349 T10350 nummod °,C
R5332 T10350 T10347 pobj C,at
R5333 T10351 T10350 punct (,C
R5334 T10352 T10353 nummod 10,s
R5335 T10353 T10350 appos s,C
R5336 T10354 T10350 punct ),C
R5337 T10355 T10350 punct ",",C
R5338 T10356 T10343 conj at,for
R5339 T10357 T10359 nummod 68,C
R534 T1761 T1762 nummod 3,mRNA
R5340 T10358 T10359 nummod °,C
R5341 T10359 T10356 pobj C,at
R5342 T10360 T10359 punct (,C
R5343 T10361 T10362 nummod 15,s
R5344 T10362 T10359 appos s,C
R5345 T10363 T10359 punct ),C
R5346 T10364 T10356 punct ",",at
R5347 T10365 T10356 cc and,at
R5348 T10366 T10356 conj at,at
R5349 T10367 T10369 nummod 72,C
R535 T1762 T1760 dobj mRNA,signaling
R5350 T10368 T10369 nummod °,C
R5351 T10369 T10366 pobj C,at
R5352 T10370 T10369 punct (,C
R5353 T10371 T10372 nummod 15,s
R5354 T10372 T10369 appos s,C
R5355 T10373 T10369 punct ),C
R5356 T10374 T10343 conj for,for
R5357 T10375 T10374 pobj SOCS3,for
R5358 T10376 T10343 punct .,for
R5359 T10377 T10378 compound Amplification,curves
R536 T1763 T1762 prep compared,mRNA
R5360 T10378 T10387 nsubjpass curves,obtained
R5361 T10379 T10378 prep of,curves
R5362 T10380 T10382 det the,values
R5363 T10381 T10382 compound fluorescence,values
R5364 T10382 T10379 pobj values,of
R5365 T10383 T10382 cc versus,values
R5366 T10384 T10385 compound cycle,number
R5367 T10385 T10387 nsubjpass number,obtained
R5368 T10386 T10387 auxpass were,obtained
R5369 T10387 T10387 ROOT obtained,obtained
R537 T1764 T1763 prep with,compared
R5370 T10388 T10387 punct ",",obtained
R5371 T10389 T10387 cc and,obtained
R5372 T10390 T10393 det a,analysis
R5373 T10391 T10393 compound melting,analysis
R5374 T10392 T10393 compound curve,analysis
R5375 T10393 T10396 nsubjpass analysis,performed
R5376 T10394 T10396 auxpass was,performed
R5377 T10395 T10396 advmod then,performed
R5378 T10396 T10387 conj performed,obtained
R5379 T10397 T10396 punct .,performed
R538 T1765 T1764 pobj control,with
R5380 T10398 T10399 det The,levels
R5381 T10399 T10406 nsubjpass levels,determined
R5382 T10400 T10399 prep of,levels
R5383 T10401 T10400 pobj SOCS1,of
R5384 T10402 T10401 cc and,SOCS1
R5385 T10403 T10401 conj SOCS3,SOCS1
R5386 T10404 T10400 pobj expression,of
R5387 T10405 T10406 auxpass were,determined
R5388 T10406 T10406 ROOT determined,determined
R5389 T10407 T10406 prep by,determined
R539 T1766 T1769 compound CD4,cells
R5390 T10408 T10407 pcomp normalizing,by
R5391 T10409 T10408 advmod relative,normalizing
R5392 T10410 T10409 prep to,relative
R5393 T10411 T10412 compound β-actin,expression
R5394 T10412 T10410 pobj expression,to
R5395 T10413 T10406 punct .,determined
R5396 T10414 T10415 det The,forward
R5397 T10415 T10419 nsubj forward,were
R5398 T10416 T10415 cc and,forward
R5399 T10417 T10415 conj reverse,forward
R540 T1767 T1769 compound +,cells
R5400 T10418 T10417 dobj primers,reverse
R5401 T10419 T10419 ROOT were,were
R5402 T10420 T10421 mark as,follows
R5403 T10421 T10419 advcl follows,were
R5404 T10422 T10419 punct :,were
R5405 T10423 T10419 prep for,were
R5406 T10424 T10423 pobj β-actin,for
R5407 T10425 T10424 punct ",",β-actin
R5408 T10426 T10424 nummod 5,β-actin
R5409 T10427 T10424 punct ',β-actin
R541 T1768 T1769 compound T,cells
R5410 T10428 T10429 punct -,GTGGGGCGCCCCAGGCACCA-3
R5411 T10429 T10424 appos GTGGGGCGCCCCAGGCACCA-3,β-actin
R5412 T10430 T10429 punct ',GTGGGGCGCCCCAGGCACCA-3
R5413 T10431 T10429 cc and,GTGGGGCGCCCCAGGCACCA-3
R5414 T10432 T10435 nummod 5,CTCCTTAATGTCACGCACGATTTC-3
R5415 T10433 T10432 punct ',5
R5416 T10434 T10435 punct -,CTCCTTAATGTCACGCACGATTTC-3
R5417 T10435 T10424 appos CTCCTTAATGTCACGCACGATTTC-3,β-actin
R5418 T10436 T10435 case ',CTCCTTAATGTCACGCACGATTTC-3
R5419 T10437 T10438 preconj ;,for
R542 T1769 T1765 dobj cells,control
R5420 T10438 T10419 prep for,were
R5421 T10439 T10438 pobj SOCS1,for
R5422 T10440 T10439 punct ",",SOCS1
R5423 T10441 T10444 nummod 5,AGACCCCTTCTCACCTCTTG-3
R5424 T10442 T10444 punct ',AGACCCCTTCTCACCTCTTG-3
R5425 T10443 T10444 punct -,AGACCCCTTCTCACCTCTTG-3
R5426 T10444 T10439 appos AGACCCCTTCTCACCTCTTG-3,SOCS1
R5427 T10445 T10444 punct ',AGACCCCTTCTCACCTCTTG-3
R5428 T10446 T10444 cc and,AGACCCCTTCTCACCTCTTG-3
R5429 T10447 T10450 nummod 5,GCACAGCAGAAAAATAAAGC-3
R543 T1770 T1744 punct ",",contained
R5430 T10448 T10447 punct ',5
R5431 T10449 T10450 punct -,GCACAGCAGAAAAATAAAGC-3
R5432 T10450 T10444 conj GCACAGCAGAAAAATAAAGC-3,AGACCCCTTCTCACCTCTTG-3
R5433 T10451 T10444 punct ',AGACCCCTTCTCACCTCTTG-3
R5434 T10452 T10444 punct ;,AGACCCCTTCTCACCTCTTG-3
R5435 T10453 T10438 cc and,for
R5436 T10454 T10438 conj for,for
R5437 T10455 T10454 pobj SOCS3,for
R5438 T10456 T10455 punct ",",SOCS3
R5439 T10457 T10460 nummod 5,CCCGCCGGCACCTTTCTG-3
R544 T1771 T1772 mark as,determined
R5440 T10458 T10457 punct ',5
R5441 T10459 T10460 punct -,CCCGCCGGCACCTTTCTG-3
R5442 T10460 T10455 appos CCCGCCGGCACCTTTCTG-3,SOCS3
R5443 T10461 T10460 punct ',CCCGCCGGCACCTTTCTG-3
R5444 T10462 T10460 cc and,CCCGCCGGCACCTTTCTG-3
R5445 T10463 T10466 nummod 5,AGGGGCCGGCTCAACACC-3
R5446 T10464 T10463 punct ',5
R5447 T10465 T10466 punct -,AGGGGCCGGCTCAACACC-3
R5448 T10466 T10460 conj AGGGGCCGGCTCAACACC-3,CCCGCCGGCACCTTTCTG-3
R5449 T10467 T10466 punct ',AGGGGCCGGCTCAACACC-3
R545 T1772 T1744 advcl determined,contained
R5450 T10468 T10419 punct .,were
R546 T1773 T1772 agent by,determined
R547 T1774 T1775 amod real-time,PCR
R548 T1775 T1773 pobj PCR,by
R549 T1776 T1738 punct .,+
R550 T1777 T1778 det These,results
R551 T1778 T1779 nsubj results,indicate
R552 T1779 T1779 ROOT indicate,indicate
R553 T1780 T1786 mark that,become
R554 T1781 T1782 compound RA,CD4
R555 T1782 T1786 nsubj CD4,become
R556 T1783 T1786 aux +,become
R557 T1784 T1785 compound T,cells
R558 T1785 T1786 nsubj cells,become
R559 T1786 T1779 ccomp become,indicate
R560 T1787 T1786 acomp resistant,become
R561 T1788 T1787 prep to,resistant
R562 T1789 T1791 det the,effect
R563 T1790 T1791 amod immunosuppressive,effect
R564 T1791 T1788 pobj effect,to
R565 T1792 T1791 prep of,effect
R566 T1793 T1792 pobj IL-10,of
R567 T1794 T1786 prep before,become
R568 T1795 T1794 pobj migration,before
R569 T1796 T1795 prep into,migration
R570 T1797 T1798 amod synovial,tissue
R571 T1798 T1796 pobj tissue,into
R572 T1799 T1786 punct ",",become
R573 T1800 T1786 cc and,become
R574 T1801 T1803 det this,IL-10
R575 T1802 T1803 amod impaired,IL-10
R576 T1803 T1807 nsubjpass IL-10,associated
R577 T1804 T1803 acl signaling,IL-10
R578 T1805 T1807 aux may,associated
R579 T1806 T1807 auxpass be,associated
R580 T1807 T1786 conj associated,become
R581 T1808 T1807 prep with,associated
R582 T1809 T1811 amod sustained,transducer
R583 T1810 T1811 compound signal,transducer
R5833 T11423 T11425 amod Western,analysis
R5834 T11424 T11425 compound blot,analysis
R5835 T11425 T11429 compound analysis,cells
R5836 T11426 T11429 compound CD4,cells
R5837 T11427 T11429 compound +,cells
R5838 T11428 T11429 compound T,cells
R5839 T11429 T11431 nsubjpass cells,stimulated
R584 T1811 T1808 pobj transducer,with
R5840 T11430 T11431 auxpass were,stimulated
R5841 T11431 T11431 ROOT stimulated,stimulated
R5842 T11432 T11431 prep for,stimulated
R5843 T11433 T11434 nummod 20,min
R5844 T11434 T11432 pobj min,for
R5845 T11435 T11434 prep by,min
R5846 T11436 T11438 det the,concentrations
R5847 T11437 T11438 amod indicated,concentrations
R5848 T11438 T11435 pobj concentrations,by
R5849 T11439 T11438 prep of,concentrations
R585 T1812 T1811 cc and,transducer
R5850 T11440 T11439 pobj IL-10,of
R5851 T11441 T11440 cc and,IL-10
R5852 T11442 T11440 conj IL-6,IL-10
R5853 T11443 T11438 prep at,concentrations
R5854 T11444 T11445 det a,density
R5855 T11445 T11443 pobj density,at
R5856 T11446 T11445 prep of,density
R5857 T11447 T11450 nummod 5,cells
R5858 T11448 T11450 nummod ×,cells
R5859 T11449 T11450 nummod 105,cells
R586 T1813 T1811 conj activator,transducer
R5860 T11450 T11446 pobj cells,of
R5861 T11451 T11438 prep in,concentrations
R5862 T11452 T11455 nummod 0.5,medium
R5863 T11453 T11455 amod ml,medium
R5864 T11454 T11455 compound culture,medium
R5865 T11455 T11451 pobj medium,in
R5866 T11456 T11455 prep with,medium
R5867 T11457 T11458 nummod 10,%
R5868 T11458 T11459 compound %,FCS
R5869 T11459 T11456 pobj FCS,with
R587 T1814 T1813 prep of,activator
R5870 T11460 T11431 punct .,stimulated
R5871 T11461 T11462 aux To,examine
R5872 T11462 T11478 advcl examine,stimulated
R5873 T11463 T11464 det the,effect
R5874 T11464 T11462 dobj effect,examine
R5875 T11465 T11464 prep of,effect
R5876 T11466 T11467 compound serum,IL-6
R5877 T11467 T11465 pobj IL-6,of
R5878 T11468 T11464 prep on,effect
R5879 T11469 T11470 compound STAT,phosphorylation
R588 T1815 T1814 pobj transcription,of
R5880 T11470 T11468 pobj phosphorylation,on
R5881 T11471 T11478 punct ",",stimulated
R5882 T11472 T11476 amod normal,cells
R5883 T11473 T11476 compound CD4,cells
R5884 T11474 T11476 nummod +,cells
R5885 T11475 T11476 compound T,cells
R5886 T11476 T11478 nsubjpass cells,stimulated
R5887 T11477 T11478 auxpass were,stimulated
R5888 T11478 T11478 ROOT stimulated,stimulated
R5889 T11479 T11478 prep for,stimulated
R589 T1816 T1815 nummod 3,transcription
R5890 T11480 T11481 nummod 20,min
R5891 T11481 T11479 pobj min,for
R5892 T11482 T11481 prep with,min
R5893 T11483 T11484 nummod 30,%
R5894 T11484 T11487 nmod %,serum
R5895 T11485 T11487 amod active,serum
R5896 T11486 T11487 compound RA,serum
R5897 T11487 T11482 pobj serum,with
R5898 T11488 T11487 prep in,serum
R5899 T11489 T11490 compound culture,medium
R590 T1817 T1815 conj activation,transcription
R5900 T11490 T11488 pobj medium,in
R5901 T11491 T11481 prep with,min
R5902 T11492 T11493 nummod 40,μg
R5903 T11493 T11495 compound μg,ml
R5904 T11494 T11495 compound /,ml
R5905 T11495 T11491 pobj ml,with
R5906 T11496 T11495 acl neutralizing,ml
R5907 T11497 T11500 nmod goat,antibody
R5908 T11498 T11500 nmod anti-IL-6,antibody
R5909 T11499 T11500 amod polyclonal,antibody
R591 T1818 T1817 cc and,activation
R5910 T11500 T11496 dobj antibody,neutralizing
R5911 T11501 T11502 punct (,IgG
R5912 T11502 T11500 appos IgG,antibody
R5913 T11503 T11502 punct ;,IgG
R5914 T11504 T11502 conj Techne,IgG
R5915 T11505 T11504 punct ",",Techne
R5916 T11506 T11504 conj Princeton,Techne
R5917 T11507 T11506 punct ",",Princeton
R5918 T11508 T11506 conj NJ,Princeton
R5919 T11509 T11508 punct ",",NJ
R592 T1819 T1817 conj suppressor,activation
R5920 T11510 T11508 conj USA,NJ
R5921 T11511 T11508 punct ),NJ
R5922 T11512 T11500 cc or,antibody
R5923 T11513 T11500 conj control,antibody
R5924 T11514 T11515 amod goat,IgG
R5925 T11515 T11513 dobj IgG,control
R5926 T11516 T11517 punct (,Techne
R5927 T11517 T11515 appos Techne,IgG
R5928 T11518 T11495 punct ),ml
R5929 T11519 T11478 punct .,stimulated
R593 T1820 T1815 prep of,transcription
R5930 T11520 T11522 amod Whole,lysates
R5931 T11521 T11522 compound cell,lysates
R5932 T11522 T11524 nsubjpass lysates,prepared
R5933 T11523 T11524 auxpass were,prepared
R5934 T11524 T11524 ROOT prepared,prepared
R5935 T11525 T11524 prep by,prepared
R5936 T11526 T11525 pcomp placing,by
R5937 T11527 T11526 dobj cells,placing
R5938 T11528 T11526 prep in,placing
R5939 T11529 T11533 nummod 100,buffer
R594 T1821 T1820 pobj cytokine,of
R5940 T11530 T11533 compound μl,buffer
R5941 T11531 T11533 compound SDS,buffer
R5942 T11532 T11533 compound lysing,buffer
R5943 T11533 T11528 pobj buffer,in
R5944 T11534 T11542 punct (,]
R5945 T11535 T11537 nummod 62.5,Tris
R5946 T11536 T11537 compound mM,Tris
R5947 T11537 T11542 nmod Tris,]
R5948 T11538 T11540 compound HCl,pH
R5949 T11539 T11540 compound [,pH
R595 T1822 T1807 advcl signaling,associated
R5950 T11540 T11537 appos pH,Tris
R5951 T11541 T11542 nummod 6.8,]
R5952 T11542 T11526 prep ],placing
R5953 T11543 T11542 punct ",",]
R5954 T11544 T11545 nummod 2,%
R5955 T11545 T11546 compound %,SDS
R5956 T11546 T11542 npadvmod SDS,]
R5957 T11547 T11546 punct ",",SDS
R5958 T11548 T11549 nummod 10,%
R5959 T11549 T11550 compound %,glycerol
R596 T1823 T1824 nummod 1,induction
R5960 T11550 T11546 appos glycerol,SDS
R5961 T11551 T11550 punct ",",glycerol
R5962 T11552 T11553 nummod 50,mM
R5963 T11553 T11554 compound mM,dithiothreitol
R5964 T11554 T11550 conj dithiothreitol,glycerol
R5965 T11555 T11554 punct ",",dithiothreitol
R5966 T11556 T11557 nummod 0.1,%
R5967 T11557 T11550 appos %,glycerol
R5968 T11558 T11559 compound bromphenol,blue
R5969 T11559 T11557 appos blue,%
R597 T1824 T1822 dobj induction,signaling
R5970 T11560 T11559 punct ),blue
R5971 T11561 T11542 punct .,]
R5972 T11562 T11568 advmod Then,fractionated
R5973 T11563 T11566 nummod 20,samples
R5974 T11564 T11566 compound μl,samples
R5975 T11565 T11566 compound protein,samples
R5976 T11566 T11568 nsubjpass samples,fractionated
R5977 T11567 T11568 auxpass were,fractionated
R5978 T11568 T11568 ROOT fractionated,fractionated
R5979 T11569 T11568 prep on,fractionated
R598 T1825 T1779 punct .,indicate
R5980 T11570 T11571 nummod 10,%
R5981 T11571 T11573 nmod %,gels
R5982 T11572 T11573 amod SDS-polyacrylamide,gels
R5983 T11573 T11569 pobj gels,on
R5984 T11574 T11568 cc and,fractionated
R5985 T11575 T11576 auxpass were,transferred
R5986 T11576 T11568 conj transferred,fractionated
R5987 T11577 T11576 prep to,transferred
R5988 T11578 T11579 amod nitrocellulose,membranes
R5989 T11579 T11577 pobj membranes,to
R5990 T11580 T11592 punct (,blocked
R5991 T11581 T11592 nsubjpass Amersham,blocked
R5992 T11582 T11581 punct ",",Amersham
R5993 T11583 T11581 conj Buckinghamshire,Amersham
R5994 T11584 T11583 punct ",",Buckinghamshire
R5995 T11585 T11583 conj UK,Buckinghamshire
R5996 T11586 T11583 punct ),Buckinghamshire
R5997 T11587 T11581 punct ",",Amersham
R5998 T11588 T11581 cc and,Amersham
R5999 T11589 T11590 det the,membrane
R6000 T11590 T11581 conj membrane,Amersham
R6001 T11591 T11592 auxpass was,blocked
R6002 T11592 T11576 parataxis blocked,transferred
R6003 T11593 T11592 prep with,blocked
R6004 T11594 T11595 nummod 5,%
R6005 T11595 T11596 nsubj %,skim
R6006 T11596 T11576 conj skim,transferred
R6007 T11597 T11596 dobj milk,skim
R6008 T11598 T11596 prep in,skim
R6009 T11599 T11600 amod Tris-buffered,saline
R6010 T11600 T11598 pobj saline,in
R6011 T11601 T11596 prep with,skim
R6012 T11602 T11603 nummod 0.1,%
R6013 T11603 T11605 quantmod %,20
R6014 T11604 T11605 nummod Tween,20
R6015 T11605 T11601 pobj 20,with
R6016 T11606 T11568 punct .,fractionated
R6017 T11607 T11608 compound Tyrosine,phosphorylation
R6018 T11608 T11614 nsubjpass phosphorylation,detected
R6019 T11609 T11608 prep of,phosphorylation
R6020 T11610 T11609 pobj STAT1,of
R6021 T11611 T11610 cc and,STAT1
R6022 T11612 T11610 conj STAT3,STAT1
R6023 T11613 T11614 auxpass was,detected
R6024 T11614 T11614 ROOT detected,detected
R6025 T11615 T11614 advcl using,detected
R6026 T11616 T11618 amod commercial,kits
R6027 T11617 T11618 amod available,kits
R6028 T11618 T11615 dobj kits,using
R6029 T11619 T11618 punct (,kits
R6030 T11620 T11622 compound Cell,Technology
R6031 T11621 T11622 compound Signaling,Technology
R6032 T11622 T11618 appos Technology,kits
R6033 T11623 T11622 punct ",",Technology
R6034 T11624 T11622 conj Beverly,Technology
R6035 T11625 T11624 punct ",",Beverly
R6036 T11626 T11624 conj MA,Beverly
R6037 T11627 T11626 punct ",",MA
R6038 T11628 T11626 appos USA,MA
R6039 T11629 T11626 punct ),MA
R6040 T11630 T11614 prep according,detected
R6041 T11631 T11630 prep to,according
R6042 T11632 T11633 det the,manufacturer
R6043 T11633 T11635 poss manufacturer,instructions
R6044 T11634 T11633 case 's,manufacturer
R6045 T11635 T11631 pobj instructions,to
R6046 T11636 T11614 punct .,detected
R6047 T11637 T11641 advmod Briefly,was
R6048 T11638 T11641 punct ",",was
R6049 T11639 T11640 det the,membrane
R6050 T11640 T11641 nsubj membrane,was
R6051 T11641 T11641 ROOT was,was
R6052 T11642 T11641 attr incubated,was
R6053 T11643 T11642 prep with,incubated
R6054 T11644 T11645 det the,antibodies
R6055 T11645 T11643 pobj antibodies,with
R6056 T11646 T11648 punct (,IgG
R6057 T11647 T11648 compound rabbit,IgG
R6058 T11648 T11645 appos IgG,antibodies
R6059 T11649 T11642 punct ),incubated
R6060 T11650 T11651 amod anti-STAT1,antibody
R6061 T11651 T11671 dep antibody,diluted
R6062 T11652 T11654 punct ",",tyrosine
R6063 T11653 T11654 amod anti-phosphorylated,tyrosine
R6064 T11654 T11651 appos tyrosine,antibody
R6065 T11655 T11654 nummod 701,tyrosine
R6066 T11656 T11654 prep of,tyrosine
R6067 T11657 T11658 nummod STAT1,antibody
R6068 T11658 T11656 pobj antibody,of
R6069 T11659 T11658 punct ",",antibody
R6070 T11660 T11661 amod anti-STAT3,antibody
R6071 T11661 T11658 conj antibody,antibody
R6072 T11662 T11661 punct ",",antibody
R6073 T11663 T11661 cc and,antibody
R6074 T11664 T11665 compound anti-phosphorylated,tyrosine
R6075 T11665 T11661 conj tyrosine,antibody
R6076 T11666 T11671 acl 705,diluted
R6077 T11667 T11666 prep of,705
R6078 T11668 T11669 nummod STAT3,antibody
R6079 T11669 T11667 pobj antibody,of
R6080 T11670 T11671 punct ",",diluted
R6081 T11671 T11641 conj diluted,was
R6082 T11672 T11673 mark as,recommended
R6083 T11673 T11671 advcl recommended,diluted
R6084 T11674 T11673 prep at,recommended
R6085 T11675 T11674 pobj 1/2000,at
R6086 T11676 T11675 prep with,1/2000
R6087 T11677 T11678 amod Tris-buffered,saline
R6088 T11678 T11676 pobj saline,with
R6089 T11679 T11673 prep with,recommended
R6090 T11680 T11681 nummod 0.1,%
R6091 T11681 T11679 pobj %,with
R6092 T11682 T11683 nummod Tween,20
R6093 T11683 T11684 nummod 20,with
R6094 T11684 T11679 conj with,with
R6095 T11685 T11686 nummod 5,%
R6096 T11686 T11687 compound %,BSA
R6097 T11687 T11684 pobj BSA,with
R6098 T11688 T11671 punct .,diluted
R6099 T11689 T11690 compound Antibody,binding
R6100 T11690 T11692 nsubjpass binding,detected
R6101 T11691 T11692 auxpass was,detected
R6102 T11692 T11692 ROOT detected,detected
R6103 T11693 T11692 agent by,detected
R6104 T11694 T11698 amod horseradish,antibody
R6105 T11695 T11698 amod peroxidase-conjugated,antibody
R6106 T11696 T11698 amod anti-rabbit,antibody
R6107 T11697 T11698 compound IgG,antibody
R6108 T11698 T11693 pobj antibody,by
R6109 T11699 T11698 acl diluted,antibody
R6110 T11700 T11699 prep at,diluted
R6111 T11701 T11700 pobj 1/4000,at
R6112 T11702 T11701 prep with,1/4000
R6113 T11703 T11704 amod Tris-buffered,saline
R6114 T11704 T11702 pobj saline,with
R6115 T11705 T11699 prep with,diluted
R6116 T11706 T11707 nummod 0.1,%
R6117 T11707 T11705 pobj %,with
R6118 T11708 T11709 nummod Tween,20
R6119 T11709 T11707 prep 20,%
R6120 T11710 T11709 prep with,20
R6121 T11711 T11712 nummod 5,%
R6122 T11712 T11713 compound %,BSA
R6123 T11713 T11710 pobj BSA,with
R6124 T11714 T11707 punct ",",%
R6125 T11715 T11692 cc and,detected
R6126 T11716 T11717 auxpass was,revealed
R6127 T11717 T11692 conj revealed,detected
R6128 T11718 T11717 advcl using,revealed
R6129 T11719 T11721 det the,system
R6130 T11720 T11721 compound chemiluminescence,system
R6131 T11721 T11718 dobj system,using
R6132 T11722 T11692 punct .,detected
R6133 T11723 T11724 compound Protein,bands
R6134 T11724 T11726 nsubjpass bands,quantified
R6135 T11725 T11726 auxpass were,quantified
R6136 T11726 T11726 ROOT quantified,quantified
R6137 T11727 T11726 agent by,quantified
R6138 T11728 T11727 pobj densitometry,by
R6139 T11729 T11726 advcl using,quantified
R6140 T11730 T11731 amod NIH-Image,analysis
R6141 T11731 T11729 dobj analysis,using
R6142 T11732 T11726 punct ",",quantified
R6143 T11733 T11726 cc and,quantified
R6144 T11734 T11735 compound STAT,phosphorylation
R6145 T11735 T11736 nsubj phosphorylation,was
R6146 T11736 T11726 conj was,quantified
R6147 T11737 T11736 prep compared,was
R6148 T11738 T11737 prep with,compared
R6149 T11739 T11741 det the,amount
R6150 T11740 T11741 amod total,amount
R6151 T11741 T11738 pobj amount,with
R6152 T11742 T11741 prep of,amount
R6153 T11743 T11744 compound STAT,protein
R6154 T11744 T11742 pobj protein,of
R6155 T11745 T11736 punct .,was
R6156 T11746 T11748 amod IFN-γ-stimulated,cells
R6157 T11747 T11748 compound Hela,cells
R6158 T11748 T11750 nsubjpass cells,used
R6159 T11749 T11750 auxpass were,used
R6160 T11750 T11750 ROOT used,used
R6161 T11751 T11750 prep as,used
R6162 T11752 T11754 det a,control
R6163 T11753 T11754 amod positive,control
R6164 T11754 T11751 pobj control,as
R6165 T11755 T11754 prep for,control
R6166 T11756 T11757 nummod STAT1,phosophorylation
R6167 T11757 T11755 pobj phosophorylation,for
R6168 T11758 T11750 punct .,used
R6255 T12022 T12023 compound Statistical,analysis
R6256 T12023 T12024 compound analysis,Data
R6257 T12024 T12026 nsubjpass Data,expressed
R6258 T12025 T12026 auxpass are,expressed
R6259 T12026 T12026 ROOT expressed,expressed
R6260 T12027 T12026 prep as,expressed
R6261 T12028 T12033 det the,error
R6262 T12029 T12033 amod mean,error
R6263 T12030 T12033 nmod value,error
R6264 T12031 T12033 nmod ±,error
R6265 T12032 T12033 amod standard,error
R6266 T12033 T12027 pobj error,as
R6267 T12034 T12033 prep of,error
R6268 T12035 T12036 det the,mean
R6269 T12036 T12034 pobj mean,of
R6270 T12037 T12036 cc or,mean
R6271 T12038 T12039 compound box,plots
R6272 T12039 T12036 conj plots,mean
R6273 T12040 T12026 punct .,expressed
R6274 T12041 T12043 det The,significance
R6275 T12042 T12043 amod statistical,significance
R6276 T12043 T12050 nsubjpass significance,determined
R6277 T12044 T12043 prep of,significance
R6278 T12045 T12044 pobj differences,of
R6279 T12046 T12045 prep between,differences
R6280 T12047 T12048 nummod two,groups
R6281 T12048 T12046 pobj groups,between
R6282 T12049 T12050 auxpass was,determined
R6283 T12050 T12050 ROOT determined,determined
R6284 T12051 T12050 agent by,determined
R6285 T12052 T12053 det the,Mann
R6286 T12053 T12051 pobj Mann,by
R6287 T12054 T12056 compound Whitney,test
R6288 T12055 T12056 compound U,test
R6289 T12056 T12060 acomp test,signed
R6290 T12057 T12056 cc or,test
R6291 T12058 T12059 det the,Wilcoxon
R6292 T12059 T12060 nsubj Wilcoxon,signed
R6293 T12060 T12050 advcl signed,determined
R6294 T12061 T12062 compound rank,test
R6295 T12062 T12060 dobj test,signed
R6296 T12063 T12050 punct .,determined
R6297 T12064 T12068 nsubjpass P,considered
R6298 T12065 T12066 amod <,0.05
R6299 T12066 T12064 nummod 0.05,P
R6300 T12067 T12068 auxpass was,considered
R6301 T12068 T12068 ROOT considered,considered
R6302 T12069 T12068 oprd significant,considered
R6303 T12070 T12068 punct .,considered
R664 T1547 T1576 nsubjpass Resistance,shown
R665 T1548 T1547 prep to,Resistance
R666 T1549 T1548 pobj IL-10,to
R667 T1550 T1547 conj inhibition,Resistance
R668 T1551 T1550 prep of,inhibition
R669 T1552 T1554 nmod interferon,production
R670 T1553 T1554 amod gamma,production
R671 T1554 T1551 pobj production,of
R672 T1555 T1554 cc and,production
R673 T1556 T1554 conj expression,production
R674 T1557 T1554 prep of,production
R675 T1558 T1557 pobj suppressor,of
R676 T1559 T1558 prep of,suppressor
R677 T1560 T1559 pobj cytokine,of
R678 T1561 T1547 acl signaling,Resistance
R679 T1562 T1561 dobj 1,signaling
R680 T1563 T1561 prep in,signaling
R681 T1570 T1569 prep with,patients
R682 T1571 T1572 compound rheumatoid,arthritis
R683 T1572 T1570 pobj arthritis,with
R684 T1573 T1576 nsubjpass IL-10,shown
R685 T1574 T1576 aux has,shown
R686 T1575 T1576 auxpass been,shown
R687 T1576 T1576 ROOT shown,shown
R6873 T13643 T13643 ROOT Resistance,Resistance
R6874 T13644 T13643 prep to,Resistance
R6875 T13645 T13644 pobj IL-10,to
R6876 T13646 T13643 conj inhibition,Resistance
R6877 T13647 T13646 prep of,inhibition
R6878 T13648 T13649 amod IFN-γ,production
R6879 T13649 T13647 pobj production,of
R688 T1577 T1578 aux to,block
R6880 T13650 T13649 prep in,production
R6881 T13651 T13652 compound RA,CD4
R6882 T13652 T13650 pobj CD4,in
R6883 T13653 T13655 amod +,cells
R6884 T13654 T13655 compound T,cells
R6885 T13655 T13643 appos cells,Resistance
R6886 T13656 T13659 det The,pathway
R6887 T13657 T13659 nummod CD28,pathway
R6888 T13658 T13659 amod costimulatory,pathway
R6889 T13659 T13660 nsubj pathway,is
R689 T1578 T1576 xcomp block,shown
R6890 T13660 T13660 ROOT is,is
R6891 T13661 T13660 acomp crucial,is
R6892 T13662 T13661 prep for,crucial
R6893 T13663 T13667 amod effective,production
R6894 T13664 T13667 amod antigen-specific,production
R6895 T13665 T13667 nmod T-cell,production
R6896 T13666 T13667 compound cytokine,production
R6897 T13667 T13662 pobj production,for
R6898 T13668 T13660 punct ",",is
R6899 T13669 T13660 cc and,is
R690 T1579 T1583 det the,response
R6900 T13670 T13673 nsubj IL-10,suppress
R6901 T13671 T13673 aux can,suppress
R6902 T13672 T13673 advmod directly,suppress
R6903 T13673 T13660 conj suppress,is
R6904 T13674 T13675 det this,response
R6905 T13675 T13673 dobj response,suppress
R6906 T13676 T13673 prep by,suppress
R6907 T13677 T13676 pcomp inhibiting,by
R6908 T13678 T13680 compound CD28,phosphorylation
R6909 T13679 T13680 compound tyrosine,phosphorylation
R691 T1580 T1583 amod antigen-specific,response
R6910 T13680 T13677 dobj phosphorylation,inhibiting
R6911 T13681 T13680 cc and,phosphorylation
R6912 T13682 T13677 advcl binding,inhibiting
R6913 T13683 T13682 prep of,binding
R6914 T13684 T13686 nmod phosphatidylinositol,[
R6915 T13685 T13686 nmod 3-kinase,[
R6916 T13686 T13688 nmod [,]
R6917 T13687 T13688 nummod 24,]
R6918 T13688 T13683 pobj ],of
R6919 T13689 T13673 punct .,suppress
R692 T1581 T1583 compound T-cell,response
R6920 T13690 T13691 aux To,evaluate
R6921 T13691 T13703 advcl evaluate,purified
R6922 T13692 T13693 det the,responsiveness
R6923 T13693 T13691 dobj responsiveness,evaluate
R6924 T13694 T13693 prep of,responsiveness
R6925 T13695 T13696 compound RA,CD4
R6926 T13696 T13694 pobj CD4,of
R6927 T13697 T13699 amod +,cells
R6928 T13698 T13699 compound T,cells
R6929 T13699 T13691 dobj cells,evaluate
R693 T1582 T1583 compound cytokine,response
R6930 T13700 T13691 prep to,evaluate
R6931 T13701 T13700 pobj IL-10,to
R6932 T13702 T13703 punct ",",purified
R6933 T13703 T13703 ROOT purified,purified
R6934 T13704 T13705 compound PB,CD4
R6935 T13705 T13703 dobj CD4,purified
R6936 T13706 T13721 csubjpass +,stimulated
R6937 T13707 T13708 compound T,cells
R6938 T13708 T13706 dobj cells,+
R6939 T13709 T13706 prep from,+
R694 T1583 T1578 dobj response,block
R6940 T13710 T13711 nummod three,patients
R6941 T13711 T13709 pobj patients,from
R6942 T13712 T13711 prep with,patients
R6943 T13713 T13714 amod active,RA
R6944 T13714 T13712 pobj RA,with
R6945 T13715 T13712 cc and,with
R6946 T13716 T13706 prep from,+
R6947 T13717 T13719 nummod three,controls
R6948 T13718 T13719 amod healthy,controls
R6949 T13719 T13716 pobj controls,from
R695 T1584 T1578 prep by,block
R6950 T13720 T13721 auxpass were,stimulated
R6951 T13721 T13703 ccomp stimulated,purified
R6952 T13722 T13721 agent by,stimulated
R6953 T13723 T13725 amod immobilized,antibody
R6954 T13724 T13725 amod anti-CD3,antibody
R6955 T13725 T13722 pobj antibody,by
R6956 T13726 T13725 cc and,antibody
R6957 T13727 T13728 compound anti-CD28,antibody
R6958 T13728 T13725 conj antibody,antibody
R6959 T13729 T13725 prep with,antibody
R696 T1585 T1584 pcomp inhibiting,by
R6960 T13730 T13729 cc or,with
R6961 T13731 T13729 conj without,with
R6962 T13732 T13733 amod diluted,concentrations
R6963 T13733 T13731 pobj concentrations,without
R6964 T13734 T13733 prep of,concentrations
R6965 T13735 T13734 pobj IL-10,of
R6966 T13736 T13733 prep for,concentrations
R6967 T13737 T13738 nummod 36,hours
R6968 T13738 T13736 pobj hours,for
R6969 T13739 T13731 punct ",",without
R697 T1586 T1587 det the,CD28
R6970 T13740 T13731 cc and,without
R6971 T13741 T13742 compound IFN-γ,production
R6972 T13742 T13744 nsubjpass production,measured
R6973 T13743 T13744 auxpass was,measured
R6974 T13744 T13703 conj measured,purified
R6975 T13745 T13744 agent by,measured
R6976 T13746 T13745 pobj ELISA,by
R6977 T13747 T13744 punct .,measured
R6978 T13748 T13749 mark As,shown
R6979 T13749 T13765 advcl shown,inhibited
R698 T1587 T1585 dobj CD28,inhibiting
R6980 T13750 T13749 prep in,shown
R6981 T13751 T13750 pobj Fig.,in
R6982 T13752 T13751 nummod 1,Fig.
R6983 T13753 T13751 punct ",",Fig.
R6984 T13754 T13755 compound IFN-γ,production
R6985 T13755 T13765 nsubjpass production,inhibited
R6986 T13756 T13755 prep by,production
R6987 T13757 T13762 amod activated,cells
R6988 T13758 T13762 amod normal,cells
R6989 T13759 T13762 compound CD4,cells
R699 T1588 T1585 conj signaling,inhibiting
R6990 T13760 T13762 nummod +,cells
R6991 T13761 T13762 compound T,cells
R6992 T13762 T13756 pobj cells,by
R6993 T13763 T13765 auxpass was,inhibited
R6994 T13764 T13765 advmod mostly,inhibited
R6995 T13765 T13765 ROOT inhibited,inhibited
R6996 T13766 T13765 prep at,inhibited
R6997 T13767 T13766 pobj concentrations,at
R6998 T13768 T13769 advmod as,low
R6999 T13769 T13767 amod low,concentrations
R700 T1589 T1588 dobj pathway,signaling
R7000 T13770 T13769 prep as,low
R7001 T13771 T13772 nummod 1,ng/ml
R7002 T13772 T13773 compound ng/ml,IL-10
R7003 T13773 T13770 pobj IL-10,as
R7004 T13774 T13765 punct .,inhibited
R7005 T13775 T13782 advmod However,were
R7006 T13776 T13782 punct ",",were
R7007 T13777 T13778 compound RA,CD4
R7008 T13778 T13781 compound CD4,cells
R7009 T13779 T13781 amod +,cells
R701 T1590 T1576 punct .,shown
R7010 T13780 T13781 compound T,cells
R7011 T13781 T13782 nsubj cells,were
R7012 T13782 T13782 ROOT were,were
R7013 T13783 T13782 acomp able,were
R7014 T13784 T13785 aux to,produce
R7015 T13785 T13783 xcomp produce,able
R7016 T13786 T13787 amod significant,amounts
R7017 T13787 T13785 dobj amounts,produce
R7018 T13788 T13787 prep of,amounts
R7019 T13789 T13788 pobj IFN-γ,of
R702 T1591 T1592 nsubj We,found
R7020 T13790 T13785 prep in,produce
R7021 T13791 T13792 det the,presence
R7022 T13792 T13790 pobj presence,in
R7023 T13793 T13792 prep of,presence
R7024 T13794 T13796 nummod 1,IL-10
R7025 T13795 T13796 compound ng/ml,IL-10
R7026 T13796 T13793 pobj IL-10,of
R7027 T13797 T13782 punct ",",were
R7028 T13798 T13782 cc and,were
R7029 T13799 T13800 det the,maximal
R703 T1592 T1592 ROOT found,found
R7030 T13800 T13808 nsubjpass maximal,obtained
R7031 T13801 T13800 cc but,maximal
R7032 T13802 T13803 neg not,complete
R7033 T13803 T13800 conj complete,maximal
R7034 T13804 T13803 dobj inhibition,complete
R7035 T13805 T13803 prep by,complete
R7036 T13806 T13805 pobj IL-10,by
R7037 T13807 T13808 auxpass was,obtained
R7038 T13808 T13782 conj obtained,were
R7039 T13809 T13808 prep at,obtained
R704 T1593 T1609 mark that,were
R7040 T13810 T13809 pobj 10,at
R7041 T13811 T13812 nummod 100,ng/ml
R7042 T13812 T13810 appos ng/ml,10
R7043 T13813 T13808 punct .,obtained
R7044 T13814 T13816 nsubj We,compared
R7045 T13815 T13816 advmod thus,compared
R7046 T13816 T13816 ROOT compared,compared
R7047 T13817 T13818 det the,levels
R7048 T13818 T13816 dobj levels,compared
R7049 T13819 T13818 prep of,levels
R705 T1594 T1595 amod peripheral,blood
R7050 T13820 T13821 compound IFN-γ,production
R7051 T13821 T13819 pobj production,of
R7052 T13822 T13821 prep by,production
R7053 T13823 T13826 compound CD4,cells
R7054 T13824 T13826 compound +,cells
R7055 T13825 T13826 compound T,cells
R7056 T13826 T13822 pobj cells,by
R7057 T13827 T13816 prep after,compared
R7058 T13828 T13831 nsubj CD3,costimulation
R7059 T13829 T13828 cc and,CD3
R706 T1595 T1599 compound blood,cells
R7060 T13830 T13828 conj CD28,CD3
R7061 T13831 T13827 pobj costimulation,after
R7062 T13832 T13831 prep in,costimulation
R7063 T13833 T13834 det the,presence
R7064 T13834 T13832 pobj presence,in
R7065 T13835 T13834 prep of,presence
R7066 T13836 T13838 nummod 1,IL-10
R7067 T13837 T13838 compound ng/ml,IL-10
R7068 T13838 T13835 pobj IL-10,of
R7069 T13839 T13838 prep in,IL-10
R707 T1596 T1599 compound CD4,cells
R7070 T13840 T13841 compound RA,patients
R7071 T13841 T13839 pobj patients,in
R7072 T13842 T13841 prep with,patients
R7073 T13843 T13844 amod active,disease
R7074 T13844 T13842 pobj disease,with
R7075 T13845 T13844 punct (,disease
R7076 T13846 T13848 amod multiple,joints
R7077 T13847 T13848 amod inflammatory,joints
R7078 T13848 T13844 appos joints,disease
R7079 T13849 T13844 punct ",",disease
R708 T1597 T1599 compound +,cells
R7080 T13850 T13851 compound CRP,level
R7081 T13851 T13852 nsubj level,≥
R7082 T13852 T13831 npadvmod ≥,costimulation
R7083 T13853 T13854 nummod 10,mg/l
R7084 T13854 T13852 appos mg/l,≥
R7085 T13855 T13852 punct ),≥
R7086 T13856 T13852 cc and,≥
R7087 T13857 T13858 amod inactive,disease
R7088 T13858 T13852 conj disease,≥
R7089 T13859 T13852 punct (,≥
R709 T1598 T1599 compound T,cells
R7090 T13860 T13852 prep in,≥
R7091 T13861 T13860 pobj remission,in
R7092 T13862 T13852 punct ",",≥
R7093 T13863 T13864 compound CRP,level
R7094 T13864 T13852 conj level,≥
R7095 T13865 T13867 nmod <,mg/l
R7096 T13866 T13867 nummod 10,mg/l
R7097 T13867 T13864 appos mg/l,level
R7098 T13868 T13864 punct ),level
R7099 T13869 T13871 nmod [,]
R710 T1599 T1609 nsubj cells,were
R7100 T13870 T13871 nummod 26,]
R7101 T13871 T13864 nmod ],level
R7102 T13872 T13827 cc and,after
R7103 T13873 T13827 conj in,after
R7104 T13874 T13875 amod healthy,controls
R7105 T13875 T13873 pobj controls,in
R7106 T13876 T13816 punct .,compared
R7107 T13877 T13878 expl There,were
R7108 T13878 T13878 ROOT were,were
R7109 T13879 T13882 det no,differences
R7110 T13880 T13881 advmod statistically,significant
R7111 T13881 T13882 amod significant,differences
R7112 T13882 T13878 attr differences,were
R7113 T13883 T13882 prep in,differences
R7114 T13884 T13885 amod IFN-γ,production
R7115 T13885 T13883 pobj production,in
R7116 T13886 T13882 prep without,differences
R7117 T13887 T13886 pobj IL-10,without
R7118 T13888 T13887 prep among,IL-10
R7119 T13889 T13891 det these,groups
R7120 T13890 T13891 nummod three,groups
R7121 T13891 T13888 pobj groups,among
R7122 T13892 T13893 punct (,Fig.
R7123 T13893 T13878 attr Fig.,were
R7124 T13894 T13893 nummod 2a,Fig.
R7125 T13895 T13893 punct ),Fig.
R7126 T13896 T13878 punct ",",were
R7127 T13897 T13878 cc but,were
R7128 T13898 T13900 det the,effect
R7129 T13899 T13900 amod inhibitory,effect
R7130 T13900 T13908 nsubjpass effect,limited
R7131 T13901 T13900 prep of,effect
R7132 T13902 T13901 pobj IL-10,of
R7133 T13903 T13902 prep on,IL-10
R7134 T13904 T13905 compound IFN-γ,production
R7135 T13905 T13903 pobj production,on
R7136 T13906 T13908 auxpass was,limited
R7137 T13907 T13908 advmod significantly,limited
R7138 T13908 T13878 conj limited,were
R7139 T13909 T13908 prep in,limited
R7140 T13910 T13913 det the,group
R7141 T13911 T13913 amod active,group
R7142 T13912 T13913 compound RA,group
R7143 T13913 T13909 pobj group,in
R7144 T13914 T13908 prep as,limited
R7145 T13915 T13914 prep compared,as
R7146 T13916 T13915 prep with,compared
R7147 T13917 T13920 det the,group
R7148 T13918 T13920 amod inactive,group
R7149 T13919 T13920 compound RA,group
R7150 T13920 T13916 pobj group,with
R7151 T13921 T13920 cc and,group
R7152 T13922 T13923 amod healthy,controls
R7153 T13923 T13920 conj controls,group
R7154 T13924 T13926 punct (,decrease
R7155 T13925 T13926 compound percentage,decrease
R7156 T13926 T13920 appos decrease,group
R7157 T13927 T13926 punct :,decrease
R7158 T13928 T13929 amod active,RA
R7159 T13929 T13926 acl RA,decrease
R7160 T13930 T13929 punct ",",RA
R7161 T13931 T13933 quantmod 2.9,14.4
R7162 T13932 T13933 quantmod ±,14.4
R7163 T13933 T13934 nummod 14.4,%
R7164 T13934 T13929 appos %,RA
R7165 T13935 T13937 punct ;,RA
R7166 T13936 T13937 amod inactive,RA
R7167 T13937 T13929 conj RA,RA
R7168 T13938 T13937 punct ",",RA
R7169 T13939 T13941 quantmod 45.6,14.4
R7170 T13940 T13941 quantmod ±,14.4
R7171 T13941 T13942 nummod 14.4,%
R7172 T13942 T13937 appos %,RA
R7173 T13943 T13937 punct ;,RA
R7174 T13944 T13937 conj controls,RA
R7175 T13945 T13944 punct ",",controls
R7176 T13946 T13948 quantmod 65.8,7.9
R7177 T13947 T13948 quantmod ±,7.9
R7178 T13948 T13949 nummod 7.9,%
R7179 T13949 T13944 appos %,controls
R7180 T13950 T13944 punct ),controls
R7181 T13951 T13937 punct (,RA
R7182 T13952 T13937 npadvmod Fig.,RA
R7183 T13953 T13952 nummod 2b,Fig.
R7184 T13954 T13937 punct ),RA
R7185 T13955 T13908 punct .,limited
R7186 T13956 T13968 prep As,produced
R7187 T13957 T13958 det a,consequence
R7188 T13958 T13956 pobj consequence,As
R7189 T13959 T13968 punct ",",produced
R7190 T13960 T13963 compound CD4,cells
R7191 T13961 T13963 compound +,cells
R7192 T13962 T13963 compound T,cells
R7193 T13963 T13968 nsubj cells,produced
R7194 T13964 T13963 prep from,cells
R7195 T13965 T13967 amod active,patients
R7196 T13966 T13967 compound RA,patients
R7197 T13967 T13964 pobj patients,from
R7198 T13968 T13968 ROOT produced,produced
R7199 T13969 T13970 amod higher,levels
R7200 T13970 T13968 dobj levels,produced
R7201 T13971 T13970 prep of,levels
R7202 T13972 T13971 pobj IFN-γ,of
R7203 T13973 T13968 prep in,produced
R7204 T13974 T13975 det the,presence
R7205 T13975 T13973 pobj presence,in
R7206 T13976 T13975 prep of,presence
R7207 T13977 T13978 nummod 1,ng/ml
R7208 T13978 T13979 compound ng/ml,IL-10
R7209 T13979 T13976 pobj IL-10,of
R7210 T13980 T13981 mark than,did
R7211 T13981 T13968 advcl did,produced
R7212 T13982 T13986 amod normal,cells
R7213 T13983 T13986 nmod CD4,cells
R7214 T13984 T13986 nummod +,cells
R7215 T13985 T13986 compound T,cells
R7216 T13986 T13981 nsubj cells,did
R7217 T13987 T13981 punct (,did
R7218 T13988 T13981 nsubj Fig.,did
R7219 T13989 T13988 nummod 2a,Fig.
R7220 T13990 T13988 punct ),Fig.
R7221 T13991 T13968 punct .,produced
R7222 T13992 T13996 prep In,compared
R7223 T13993 T13992 pobj addition,In
R7224 T13994 T13996 punct ",",compared
R7225 T13995 T13996 nsubj we,compared
R7226 T13996 T13996 ROOT compared,compared
R7227 T13997 T13998 compound IL-2,production
R7228 T13998 T13996 dobj production,compared
R7229 T13999 T13998 prep by,production
R7230 T14000 T14003 compound CD4,cells
R7231 T14001 T14003 compound +,cells
R7232 T14002 T14003 compound T,cells
R7233 T14003 T13999 pobj cells,by
R7234 T14004 T13996 prep after,compared
R7235 T14005 T14008 nsubj CD3,costimulation
R7236 T14006 T14005 cc and,CD3
R7237 T14007 T14005 conj CD28,CD3
R7238 T14008 T14004 pobj costimulation,after
R7239 T14009 T14008 prep in,costimulation
R7240 T14010 T14011 det the,presence
R7241 T14011 T14009 pobj presence,in
R7242 T14012 T14011 prep of,presence
R7243 T14013 T14012 pobj IL-10,of
R7244 T14014 T14013 prep in,IL-10
R7245 T14015 T14017 amod active,patients
R7246 T14016 T14017 compound RA,patients
R7247 T14017 T14014 pobj patients,in
R7248 T14018 T14014 cc and,in
R7249 T14019 T14014 conj in,in
R7250 T14020 T14021 amod healthy,controls
R7251 T14021 T14019 pobj controls,in
R7252 T14022 T13996 punct .,compared
R7253 T14023 T14029 advmod Similarly,affected
R7254 T14024 T14029 punct ",",affected
R7255 T14025 T14026 compound IL-2,production
R7256 T14026 T14029 nsubjpass production,affected
R7257 T14027 T14029 auxpass was,affected
R7258 T14028 T14029 neg not,affected
R7259 T14029 T14029 ROOT affected,affected
R7260 T14030 T14029 agent by,affected
R7261 T14031 T14033 nummod 1,IL-10
R7262 T14032 T14033 compound ng/ml,IL-10
R7263 T14033 T14030 pobj IL-10,by
R7264 T14034 T14033 prep in,IL-10
R7265 T14035 T14036 compound RA,patients
R7266 T14036 T14034 pobj patients,in
R7267 T14037 T14039 punct (,decrease
R7268 T14038 T14039 compound percentage,decrease
R7269 T14039 T14033 appos decrease,IL-10
R7270 T14040 T14039 punct ",",decrease
R7271 T14041 T14042 nummod -2.1,±
R7272 T14042 T14039 appos ±,decrease
R7273 T14043 T14044 nummod 13.8,%
R7274 T14044 T14042 appos %,±
R7275 T14045 T14042 punct ),±
R7276 T14046 T14029 punct ",",affected
R7277 T14047 T14051 mark while,reduced
R7278 T14048 T14051 nsubjpass it,reduced
R7279 T14049 T14051 auxpass was,reduced
R7280 T14050 T14051 advmod significantly,reduced
R7281 T14051 T14029 advcl reduced,affected
R7282 T14052 T14051 prep in,reduced
R7283 T14053 T14054 amod healthy,controls
R7284 T14054 T14052 pobj controls,in
R7285 T14055 T14057 punct (,±
R7286 T14056 T14057 nummod 61.1,±
R7287 T14057 T14029 dep ±,affected
R7288 T14058 T14059 nummod 13.7,%
R7289 T14059 T14057 appos %,±
R7290 T14060 T14062 punct ;,<
R7291 T14061 T14062 compound P,<
R7292 T14062 T14057 appos <,±
R7293 T14063 T14062 nummod 0.05,<
R7294 T14064 T14062 punct ),<
R7295 T14065 T14029 punct .,affected
R7296 T14066 T14071 advcl Taken,indicate
R7297 T14067 T14066 advmod together,Taken
R7298 T14068 T14071 punct ",",indicate
R7299 T14069 T14070 det these,results
R7300 T14070 T14071 nsubj results,indicate
R7301 T14071 T14071 ROOT indicate,indicate
R7302 T14072 T14078 mark that,become
R7303 T14073 T14074 compound RA,CD4
R7304 T14074 T14078 nsubj CD4,become
R7305 T14075 T14077 amod +,cells
R7306 T14076 T14077 compound T,cells
R7307 T14077 T14078 nsubj cells,become
R7308 T14078 T14071 ccomp become,indicate
R7309 T14079 T14080 advmod less,susceptible
R7310 T14080 T14078 acomp susceptible,become
R7311 T14081 T14080 prep to,susceptible
R7312 T14082 T14084 det the,effect
R7313 T14083 T14084 amod immunoregulatory,effect
R7314 T14084 T14081 pobj effect,to
R7315 T14085 T14084 prep of,effect
R7316 T14086 T14085 pobj IL-10,of
R7317 T14087 T14084 prep during,effect
R7318 T14088 T14090 det the,phase
R7319 T14089 T14090 amod active,phase
R7320 T14090 T14087 pobj phase,during
R7321 T14091 T14071 punct .,indicate
R7612 T15039 T15040 amod Increased,expression
R7613 T15040 T15040 ROOT expression,expression
R7614 T15041 T15040 prep of,expression
R7615 T15042 T15043 compound cell,surface
R7616 T15043 T15044 compound surface,IL-10R1
R7617 T15044 T15041 pobj IL-10R1,of
R7618 T15045 T15040 prep on,expression
R7619 T15046 T15047 compound RA,CD4
R7620 T15047 T15045 pobj CD4,on
R7621 T15048 T15050 amod +,cells
R7622 T15049 T15050 compound T,cells
R7623 T15050 T15040 conj cells,expression
R7624 T15051 T15054 det The,complex
R7625 T15052 T15054 amod functional,complex
R7626 T15053 T15054 compound receptor,complex
R7627 T15054 T15057 nsubj complex,consists
R7628 T15055 T15054 prep of,complex
R7629 T15056 T15055 pobj IL-10,of
R7630 T15057 T15057 ROOT consists,consists
R7631 T15058 T15057 prep of,consists
R7632 T15059 T15060 nummod two,subunits
R7633 T15060 T15058 pobj subunits,of
R7634 T15061 T15060 punct ",",subunits
R7635 T15062 T15065 det the,component
R7636 T15063 T15065 amod primary,component
R7637 T15064 T15065 amod ligand-binding,component
R7638 T15065 T15066 compound component,IL-10R1
R7639 T15066 T15060 appos IL-10R1,subunits
R7640 T15067 T15066 cc and,IL-10R1
R7641 T15068 T15070 det the,component
R7642 T15069 T15070 compound accessory,component
R7643 T15070 T15071 compound component,type
R7644 T15071 T15066 conj type,IL-10R1
R7645 T15072 T15076 nummod 2,]
R7646 T15073 T15074 compound IL-10R,[
R7647 T15074 T15076 nmod [,]
R7648 T15075 T15076 nummod 1,]
R7649 T15076 T15066 conj ],IL-10R1
R7650 T15077 T15057 punct .,consists
R7651 T15078 T15079 nummod IL-10R1,expression
R7652 T15079 T15080 nsubj expression,plays
R7653 T15080 T15080 ROOT plays,plays
R7654 T15081 T15083 det a,role
R7655 T15082 T15083 amod critical,role
R7656 T15083 T15080 dobj role,plays
R7657 T15084 T15083 prep in,role
R7658 T15085 T15086 amod cellular,responses
R7659 T15086 T15084 pobj responses,in
R7660 T15087 T15086 prep to,responses
R7661 T15088 T15089 compound IL-10,[
R7662 T15089 T15087 pobj [,to
R7663 T15090 T15091 nummod 29,]
R7664 T15091 T15089 dobj ],[
R7665 T15092 T15080 punct .,plays
R7666 T15093 T15094 aux To,examine
R7667 T15094 T15107 advcl examine,was
R7668 T15095 T15104 mark whether,+
R7669 T15096 T15097 det the,resistance
R7670 T15097 T15104 nsubj resistance,+
R7671 T15098 T15097 prep to,resistance
R7672 T15099 T15100 compound IL-10,inhibition
R7673 T15100 T15098 pobj inhibition,to
R7674 T15101 T15100 prep in,inhibition
R7675 T15102 T15103 compound RA,CD4
R7676 T15103 T15101 pobj CD4,in
R7677 T15104 T15106 amod +,cells
R7678 T15105 T15106 compound T,cells
R7679 T15106 T15094 dobj cells,examine
R7680 T15107 T15107 ROOT was,was
R7681 T15108 T15107 acomp due,was
R7682 T15109 T15135 prep to,determined
R7683 T15110 T15112 amod limited,expression
R7684 T15111 T15112 compound receptor,expression
R7685 T15112 T15109 pobj expression,to
R7686 T15113 T15112 punct ",",expression
R7687 T15114 T15117 det the,expression
R7688 T15115 T15116 compound cell,surface
R7689 T15116 T15117 compound surface,expression
R7690 T15117 T15112 appos expression,expression
R7691 T15118 T15117 prep of,expression
R7692 T15119 T15118 pobj IL-10R1,of
R7693 T15120 T15117 prep on,expression
R7694 T15121 T15122 compound PB,CD4
R7695 T15122 T15120 pobj CD4,on
R7696 T15123 T15125 amod +,cells
R7697 T15124 T15125 compound T,cells
R7698 T15125 T15135 nsubjpass cells,determined
R7699 T15126 T15125 prep from,cells
R7700 T15127 T15129 amod active,patients
R7701 T15128 T15129 compound RA,patients
R7702 T15129 T15126 pobj patients,from
R7703 T15130 T15126 cc and,from
R7704 T15131 T15126 conj from,from
R7705 T15132 T15133 amod healthy,controls
R7706 T15133 T15131 pobj controls,from
R7707 T15134 T15135 auxpass was,determined
R7708 T15135 T15108 xcomp determined,due
R7709 T15136 T15135 agent by,determined
R7710 T15137 T15136 pobj flow,by
R7711 T15138 T15139 amod cytometric,analysis
R7712 T15139 T15135 npadvmod analysis,determined
R7713 T15140 T15107 punct .,was
R7714 T15141 T15142 mark As,shown
R7715 T15142 T15161 advcl shown,increased
R7716 T15143 T15142 prep in,shown
R7717 T15144 T15143 pobj Fig.,in
R7718 T15145 T15144 nummod 3a,Fig.
R7719 T15146 T15147 nummod ",3",b
R7720 T15147 T15161 npadvmod b,increased
R7721 T15148 T15161 punct ",",increased
R7722 T15149 T15150 det the,intensity
R7723 T15150 T15161 nsubjpass intensity,increased
R7724 T15151 T15150 prep of,intensity
R7725 T15152 T15153 amod IL-10R1,expression
R7726 T15153 T15151 pobj expression,of
R7727 T15154 T15150 prep on,intensity
R7728 T15155 T15158 compound CD4,cells
R7729 T15156 T15158 compound +,cells
R7730 T15157 T15158 compound T,cells
R7731 T15158 T15154 pobj cells,on
R7732 T15159 T15161 auxpass was,increased
R7733 T15160 T15161 advmod significantly,increased
R7734 T15161 T15161 ROOT increased,increased
R7735 T15162 T15161 prep in,increased
R7736 T15163 T15164 compound RA,patients
R7737 T15164 T15162 pobj patients,in
R7738 T15165 T15161 prep compared,increased
R7739 T15166 T15165 prep with,compared
R7740 T15167 T15166 prep in,with
R7741 T15168 T15169 amod healthy,controls
R7742 T15169 T15167 pobj controls,in
R7743 T15170 T15161 punct .,increased
R7744 T15171 T15172 det These,results
R7745 T15172 T15173 nsubj results,suggest
R7746 T15173 T15173 ROOT suggest,suggest
R7747 T15174 T15184 mark that,impaired
R7748 T15175 T15179 det the,pathway
R7749 T15176 T15179 amod intracellular,pathway
R7750 T15177 T15179 nmod signal,pathway
R7751 T15178 T15179 compound transduction,pathway
R7752 T15179 T15184 nsubjpass pathway,impaired
R7753 T15180 T15179 prep of,pathway
R7754 T15181 T15180 pobj IL-10,of
R7755 T15182 T15184 aux may,impaired
R7756 T15183 T15184 auxpass be,impaired
R7757 T15184 T15173 ccomp impaired,suggest
R7758 T15185 T15184 prep in,impaired
R7759 T15186 T15189 nummod CD4,cells
R7760 T15187 T15189 nummod +,cells
R7761 T15188 T15189 compound T,cells
R7762 T15189 T15185 pobj cells,in
R7763 T15190 T15189 prep of,cells
R7764 T15191 T15192 amod active,RA
R7765 T15192 T15190 pobj RA,of
R7766 T15193 T15173 punct .,suggest
R8282 T16494 T16497 amod Defective,phosphorylation
R8283 T16495 T16497 amod IL-10-mediated,phosphorylation
R8284 T16496 T16497 nummod STAT3,phosphorylation
R8285 T16497 T16501 nsubj phosphorylation,+
R8286 T16498 T16497 prep in,phosphorylation
R8287 T16499 T16500 compound RA,CD4
R8288 T16500 T16498 pobj CD4,in
R8289 T16501 T16501 ROOT +,+
R8290 T16502 T16503 compound T,cells
R8291 T16503 T16501 dobj cells,+
R8292 T16504 T16505 det The,interaction
R8293 T16505 T16510 nsubj interaction,induces
R8294 T16506 T16505 prep of,interaction
R8295 T16507 T16506 pobj IL-10R,of
R8296 T16508 T16505 prep with,interaction
R8297 T16509 T16508 pobj IL-10,with
R8298 T16510 T16501 dep induces,+
R8299 T16511 T16512 compound tyrosine,phosphorylation
R8300 T16512 T16510 dobj phosphorylation,induces
R8301 T16513 T16512 cc and,phosphorylation
R8302 T16514 T16512 conj activation,phosphorylation
R8303 T16515 T16512 prep of,phosphorylation
R8304 T16516 T16519 det the,factors
R8305 T16517 T16519 amod latent,factors
R8306 T16518 T16519 compound transcription,factors
R8307 T16519 T16515 pobj factors,of
R8308 T16520 T16525 nmod STAT1,]
R8309 T16521 T16520 cc and,STAT1
R8310 T16522 T16523 compound STAT3,[
R8311 T16523 T16520 conj [,STAT1
R8312 T16524 T16525 nummod 3,]
R8313 T16525 T16512 appos ],phosphorylation
R8314 T16526 T16510 punct .,induces
R8315 T16527 T16529 amod Macrophage-specific,mice
R8316 T16528 T16529 amod STAT3-deficient,mice
R8317 T16529 T16530 nsubj mice,demonstrated
R8318 T16530 T16530 ROOT demonstrated,demonstrated
R8319 T16531 T16533 mark that,plays
R8320 T16532 T16533 nsubj STAT3,plays
R8321 T16533 T16530 ccomp plays,demonstrated
R8322 T16534 T16536 det a,role
R8323 T16535 T16536 amod dominant,role
R8324 T16536 T16533 dobj role,plays
R8325 T16537 T16536 prep in,role
R8326 T16538 T16540 amod IL-10-mediated,responses
R8327 T16539 T16540 amod anti-inflammatory,responses
R8328 T16540 T16537 pobj responses,in
R8329 T16541 T16543 nmod [,]
R8330 T16542 T16543 nummod 5,]
R8331 T16543 T16533 npadvmod ],plays
R8332 T16544 T16543 punct ",",]
R8333 T16545 T16549 nsubj which,confirmed
R8334 T16546 T16549 aux has,confirmed
R8335 T16547 T16549 advmod recently,confirmed
R8336 T16548 T16549 auxpass been,confirmed
R8337 T16549 T16543 relcl confirmed,]
R8338 T16550 T16549 prep in,confirmed
R8339 T16551 T16552 amod human,macrophages
R8340 T16552 T16550 pobj macrophages,in
R8341 T16553 T16549 agent by,confirmed
R8342 T16554 T16553 pobj studies,by
R8343 T16555 T16554 prep of,studies
R8344 T16556 T16557 amod dominant-negative,STAT3
R8345 T16557 T16555 pobj STAT3,of
R8346 T16558 T16559 compound overexpression,[
R8347 T16559 T16561 nmod [,]
R8348 T16560 T16559 nummod 30,[
R8349 T16561 T16561 ROOT ],]
R8350 T16562 T16530 punct .,demonstrated
R8351 T16563 T16564 det The,induction
R8352 T16564 T16587 nsubjpass induction,examined
R8353 T16565 T16564 prep of,induction
R8354 T16566 T16565 pobj STAT1,of
R8355 T16567 T16566 cc and,STAT1
R8356 T16568 T16569 nummod STAT3,phosphorylation
R8357 T16569 T16566 conj phosphorylation,STAT1
R8358 T16570 T16569 agent by,phosphorylation
R8359 T16571 T16570 pobj IL-10,by
R8360 T16572 T16569 prep in,phosphorylation
R8361 T16573 T16574 compound PB,CD4
R8362 T16574 T16572 pobj CD4,in
R8363 T16575 T16587 nsubjpass +,examined
R8364 T16576 T16577 compound T,cells
R8365 T16577 T16575 dobj cells,+
R8366 T16578 T16577 prep from,cells
R8367 T16579 T16581 amod active,patients
R8368 T16580 T16581 compound RA,patients
R8369 T16581 T16578 pobj patients,from
R8370 T16582 T16578 cc and,from
R8371 T16583 T16578 conj from,from
R8372 T16584 T16585 amod healthy,controls
R8373 T16585 T16583 pobj controls,from
R8374 T16586 T16587 auxpass was,examined
R8375 T16587 T16587 ROOT examined,examined
R8376 T16588 T16587 advcl using,examined
R8377 T16589 T16590 amod western,blotting
R8378 T16590 T16588 dobj blotting,using
R8379 T16591 T16587 punct .,examined
R8380 T16592 T16593 nummod STAT3,phosphorylation
R8381 T16593 T16596 nsubjpass phosphorylation,induced
R8382 T16594 T16596 auxpass was,induced
R8383 T16595 T16596 advmod dose-dependently,induced
R8384 T16596 T16596 ROOT induced,induced
R8385 T16597 T16596 prep after,induced
R8386 T16598 T16599 compound IL-10,activation
R8387 T16599 T16597 pobj activation,after
R8388 T16600 T16596 prep for,induced
R8389 T16601 T16602 nummod 20,min
R8390 T16602 T16600 pobj min,for
R8391 T16603 T16602 prep in,min
R8392 T16604 T16608 amod normal,cells
R8393 T16605 T16608 nmod CD4,cells
R8394 T16606 T16608 nummod +,cells
R8395 T16607 T16608 compound T,cells
R8396 T16608 T16603 pobj cells,in
R8397 T16609 T16602 punct (,min
R8398 T16610 T16613 nmod Fig.,b
R8399 T16611 T16610 nummod 4a,Fig.
R8400 T16612 T16610 nummod ",4",Fig.
R8401 T16613 T16602 appos b,min
R8402 T16614 T16602 punct ),min
R8403 T16615 T16596 punct .,induced
R8404 T16616 T16621 prep In,phosphorylated
R8405 T16617 T16616 pobj contrast,In
R8406 T16618 T16621 punct ",",phosphorylated
R8407 T16619 T16621 nsubjpass STAT3,phosphorylated
R8408 T16620 T16621 auxpass was,phosphorylated
R8409 T16621 T16621 ROOT phosphorylated,phosphorylated
R8410 T16622 T16621 prep in,phosphorylated
R8411 T16623 T16624 advmod freshly,isolated
R8412 T16624 T16626 amod isolated,CD4
R8413 T16625 T16626 compound PB,CD4
R8414 T16626 T16622 pobj CD4,in
R8415 T16627 T16628 amod +,cells
R8416 T16628 T16636 nsubj cells,was
R8417 T16629 T16628 prep from,cells
R8418 T16630 T16631 compound RA,patients
R8419 T16631 T16629 pobj patients,from
R8420 T16632 T16628 cc and,cells
R8421 T16633 T16635 det this,phosphorylation
R8422 T16634 T16635 nummod STAT3,phosphorylation
R8423 T16635 T16628 conj phosphorylation,cells
R8424 T16636 T16621 ccomp was,phosphorylated
R8425 T16637 T16636 acomp detectable,was
R8426 T16638 T16636 prep for,was
R8427 T16639 T16641 quantmod up,6
R8428 T16640 T16641 quantmod to,6
R8429 T16641 T16642 nummod 6,hours
R8430 T16642 T16638 pobj hours,for
R8431 T16643 T16636 punct .,was
R8432 T16644 T16645 nummod STAT3,phosphorylation
R8433 T16645 T16647 nsubjpass phosphorylation,augmented
R8434 T16646 T16647 auxpass was,augmented
R8435 T16647 T16647 ROOT augmented,augmented
R8436 T16648 T16649 advmod only,when
R8437 T16649 T16650 advmod when,activated
R8438 T16650 T16647 advcl activated,augmented
R8439 T16651 T16650 agent by,activated
R8440 T16652 T16655 advmod as,10
R8441 T16653 T16655 amod much,10
R8442 T16654 T16655 quantmod as,10
R8443 T16655 T16657 nummod 10,IL-10
R8444 T16656 T16657 compound ng/ml,IL-10
R8445 T16657 T16651 pobj IL-10,by
R8446 T16658 T16647 punct .,augmented
R8447 T16659 T16662 preconj Both,phosphorylation
R8448 T16660 T16662 amod sustained,phosphorylation
R8449 T16661 T16662 nummod STAT3,phosphorylation
R8450 T16662 T16669 nsubjpass phosphorylation,found
R8451 T16663 T16662 cc and,phosphorylation
R8452 T16664 T16667 amod defective,phosphorylation
R8453 T16665 T16667 amod IL-10-induced,phosphorylation
R8454 T16666 T16667 nummod STAT3,phosphorylation
R8455 T16667 T16662 conj phosphorylation,phosphorylation
R8456 T16668 T16669 auxpass were,found
R8457 T16669 T16669 ROOT found,found
R8458 T16670 T16669 prep in,found
R8459 T16671 T16672 compound RA,ST
R8460 T16672 T16673 compound ST,CD4
R8461 T16673 T16670 pobj CD4,in
R8462 T16674 T16676 amod +,cells
R8463 T16675 T16676 compound T,cells
R8464 T16676 T16669 advcl cells,found
R8465 T16677 T16678 punct (,Fig.
R8466 T16678 T16676 appos Fig.,cells
R8467 T16679 T16678 nummod 4c,Fig.
R8468 T16680 T16676 punct ),cells
R8469 T16681 T16669 punct .,found
R8470 T16682 T16692 prep On,detected
R8471 T16683 T16685 det the,hand
R8472 T16684 T16685 amod other,hand
R8473 T16685 T16682 pobj hand,On
R8474 T16686 T16692 punct ",",detected
R8475 T16687 T16689 amod IL-10-induced,phosphorylation
R8476 T16688 T16689 nummod STAT1,phosphorylation
R8477 T16689 T16692 nsubjpass phosphorylation,detected
R8478 T16690 T16692 auxpass was,detected
R8479 T16691 T16692 neg not,detected
R8480 T16692 T16692 ROOT detected,detected
R8481 T16693 T16692 prep in,detected
R8482 T16694 T16696 det either,CD4
R8483 T16695 T16696 compound RA,CD4
R8484 T16696 T16693 pobj CD4,in
R8485 T16697 T16699 amod +,cells
R8486 T16698 T16699 compound T,cells
R8487 T16699 T16692 dobj cells,detected
R8488 T16700 T16699 cc or,cells
R8489 T16701 T16705 amod normal,cells
R8490 T16702 T16705 nmod CD4,cells
R8491 T16703 T16705 nummod +,cells
R8492 T16704 T16705 compound T,cells
R8493 T16705 T16699 conj cells,cells
R8494 T16706 T16692 punct (,detected
R8495 T16707 T16692 npadvmod Fig.,detected
R8496 T16708 T16707 nummod 4a,Fig.
R8497 T16709 T16707 punct ),Fig.
R8498 T16710 T16692 punct .,detected
R8499 T16711 T16712 det These,results
R8500 T16712 T16713 nsubj results,indicate
R8501 T16713 T16713 ROOT indicate,indicate
R8502 T16714 T16716 mark that,is
R8503 T16715 T16716 nsubj STAT3,is
R8504 T16716 T16713 ccomp is,indicate
R8505 T16717 T16720 det the,STAT
R8506 T16718 T16720 amod major,STAT
R8507 T16719 T16720 compound IL-10-activated,STAT
R8508 T16720 T16716 attr STAT,is
R8509 T16721 T16720 prep in,STAT
R8510 T16722 T16721 pobj CD4,in
R8511 T16723 T16725 compound +,cells
R8512 T16724 T16725 compound T,cells
R8513 T16725 T16733 nsubjpass cells,diminished
R8514 T16726 T16725 punct ",",cells
R8515 T16727 T16725 cc and,cells
R8516 T16728 T16730 amod IL-10-induced,activation
R8517 T16729 T16730 compound STAT3,activation
R8518 T16730 T16725 conj activation,cells
R8519 T16731 T16733 aux may,diminished
R8520 T16732 T16733 auxpass be,diminished
R8521 T16733 T16713 conj diminished,indicate
R8522 T16734 T16733 prep in,diminished
R8523 T16735 T16736 amod active,RA
R8524 T16736 T16734 pobj RA,in
R8525 T16737 T16733 punct ",",diminished
R8526 T16738 T16733 prep in,diminished
R8527 T16739 T16738 pobj association,in
R8528 T16740 T16733 prep with,diminished
R8529 T16741 T16743 amod sustained,phosphorylation
R8530 T16742 T16743 compound STAT3,phosphorylation
R8531 T16743 T16740 pobj phosphorylation,with
R8532 T16744 T16713 punct .,indicate
R9441 T19005 T19005 ROOT IL-6-mediated,IL-6-mediated
R9442 T19006 T19007 nummod STAT3,phosphorylation
R9443 T19007 T19021 nsubjpass phosphorylation,activated
R9444 T19008 T19007 cc and,phosphorylation
R9445 T19009 T19007 conj inhibition,phosphorylation
R9446 T19010 T19009 prep of,inhibition
R9447 T19011 T19012 amod IL-10,effect
R9448 T19012 T19010 pobj effect,of
R9449 T19013 T19007 prep in,phosphorylation
R9450 T19014 T19018 amod normal,cells
R9451 T19015 T19017 compound CD4,T
R9452 T19016 T19017 compound +,T
R9453 T19017 T19018 compound T,cells
R9454 T19018 T19013 pobj cells,in
R9455 T19019 T19021 nsubjpass STAT3,activated
R9456 T19020 T19021 auxpass is,activated
R9457 T19021 T19021 ROOT activated,activated
R9458 T19022 T19021 agent by,activated
R9459 T19023 T19024 amod many,cytokines
R9460 T19024 T19022 pobj cytokines,by
R9461 T19025 T19024 cc and,cytokines
R9462 T19026 T19027 compound growth,factors
R9463 T19027 T19024 conj factors,cytokines
R9464 T19028 T19029 amod such,as
R9465 T19029 T19027 prep as,factors
R9466 T19030 T19032 det the,family
R9467 T19031 T19032 compound IL-6,family
R9468 T19032 T19029 pobj family,as
R9469 T19033 T19032 prep of,family
R9470 T19034 T19033 pobj cytokines,of
R9471 T19035 T19042 punct (,factor
R9472 T19036 T19042 nmod IL-6,factor
R9473 T19037 T19036 punct ",",IL-6
R9474 T19038 T19036 conj IL-11,IL-6
R9475 T19039 T19038 punct ",",IL-11
R9476 T19040 T19042 nmod leukemia,factor
R9477 T19041 T19042 amod inhibitory,factor
R9478 T19042 T19032 appos factor,family
R9479 T19043 T19042 punct ",",factor
R9480 T19044 T19042 cc and,factor
R9481 T19045 T19046 compound oncostatin,M
R9482 T19046 T19042 conj M,factor
R9483 T19047 T19032 punct ),family
R9484 T19048 T19051 punct ",",factor
R9485 T19049 T19051 amod platelet-derived,factor
R9486 T19050 T19051 compound growth,factor
R9487 T19051 T19027 conj factor,factors
R9488 T19052 T19051 punct ",",factor
R9489 T19053 T19051 cc and,factor
R9490 T19054 T19056 amod epidermal,factor
R9491 T19055 T19056 compound growth,factor
R9492 T19056 T19051 conj factor,factor
R9493 T19057 T19051 punct ",",factor
R9494 T19058 T19070 prep in,demonstrated
R9495 T19059 T19058 pobj addition,in
R9496 T19060 T19059 prep to,addition
R9497 T19061 T19060 pobj IL-10,to
R9498 T19062 T19064 nmod [,]
R9499 T19063 T19064 nummod 4,]
R9500 T19064 T19061 dobj ],IL-10
R9501 T19065 T19061 punct ",",IL-10
R9502 T19066 T19070 cc but,demonstrated
R9503 T19067 T19068 amod previous,studies
R9504 T19068 T19070 nsubj studies,demonstrated
R9505 T19069 T19070 aux have,demonstrated
R9506 T19070 T19021 conj demonstrated,activated
R9507 T19071 T19073 mark that,is
R9508 T19072 T19073 nsubj IL-6,is
R9509 T19073 T19070 ccomp is,demonstrated
R9510 T19074 T19076 det the,factor
R9511 T19075 T19076 amod major,factor
R9512 T19076 T19073 attr factor,is
R9513 T19077 T19076 prep in,factor
R9514 T19078 T19080 nmod RA,fluid
R9515 T19079 T19080 amod synovial,fluid
R9516 T19080 T19076 appos fluid,factor
R9517 T19081 T19082 nsubj that,induces
R9518 T19082 T19080 relcl induces,fluid
R9519 T19083 T19084 amod constitutive,activation
R9520 T19084 T19082 dobj activation,induces
R9521 T19085 T19084 prep of,activation
R9522 T19086 T19085 pobj STAT3,of
R9523 T19087 T19084 prep in,activation
R9524 T19088 T19089 amod mononuclear,cells
R9525 T19089 T19087 pobj cells,in
R9526 T19090 T19092 nmod [,]
R9527 T19091 T19092 nummod 31,]
R9528 T19092 T19080 appos ],fluid
R9529 T19093 T19070 punct .,demonstrated
R9530 T19094 T19096 mark Since,is
R9531 T19095 T19096 nsubj IL-6,is
R9532 T19096 T19107 advcl is,detected
R9533 T19097 T19096 advmod also,is
R9534 T19098 T19096 acomp abundant,is
R9535 T19099 T19098 prep in,abundant
R9536 T19100 T19099 pobj sera,in
R9537 T19101 T19100 prep of,sera
R9538 T19102 T19104 amod active,patients
R9539 T19103 T19104 compound RA,patients
R9540 T19104 T19101 pobj patients,of
R9541 T19105 T19107 punct ",",detected
R9542 T19106 T19107 advmod frequently,detected
R9543 T19107 T19117 advcl detected,examined
R9544 T19108 T19107 prep at,detected
R9545 T19109 T19108 pobj >,at
R9546 T19110 T19114 nummod 1,]
R9547 T19111 T19112 amod ng/ml,[
R9548 T19112 T19114 nmod [,]
R9549 T19113 T19114 nummod 27,]
R9550 T19114 T19107 dobj ],detected
R9551 T19115 T19117 punct ",",examined
R9552 T19116 T19117 nsubj we,examined
R9553 T19117 T19117 ROOT examined,examined
R9554 T19118 T19135 mark whether,was
R9555 T19119 T19120 amod persistent,exposure
R9556 T19120 T19135 nsubj exposure,was
R9557 T19121 T19120 prep of,exposure
R9558 T19122 T19125 nummod CD4,cells
R9559 T19123 T19125 nummod +,cells
R9560 T19124 T19125 compound T,cells
R9561 T19125 T19121 pobj cells,of
R9562 T19126 T19120 prep to,exposure
R9563 T19127 T19128 amod high,concentrations
R9564 T19128 T19126 pobj concentrations,to
R9565 T19129 T19128 prep of,concentrations
R9566 T19130 T19129 pobj IL-6,of
R9567 T19131 T19128 prep in,concentrations
R9568 T19132 T19134 det the,circulation
R9569 T19133 T19134 compound blood,circulation
R9570 T19134 T19131 pobj circulation,in
R9571 T19135 T19117 ccomp was,examined
R9572 T19136 T19135 acomp responsible,was
R9573 T19137 T19136 prep for,responsible
R9574 T19138 T19141 poss their,activation
R9575 T19139 T19141 amod sustained,activation
R9576 T19140 T19141 nummod STAT3,activation
R9577 T19141 T19137 pobj activation,for
R9578 T19142 T19141 cc and,activation
R9579 T19143 T19141 conj resistance,activation
R9580 T19144 T19143 prep to,resistance
R9581 T19145 T19146 compound IL-10,inhibition
R9582 T19146 T19144 pobj inhibition,to
R9583 T19147 T19146 prep in,inhibition
R9584 T19148 T19149 amod active,RA
R9585 T19149 T19147 pobj RA,in
R9586 T19150 T19117 punct .,examined
R9587 T19151 T19152 det Both,STAT1
R9588 T19152 T19155 nummod STAT1,phosphorylation
R9589 T19153 T19152 cc and,STAT1
R9590 T19154 T19152 conj STAT3,STAT1
R9591 T19155 T19157 nsubjpass phosphorylation,activated
R9592 T19156 T19157 auxpass was,activated
R9593 T19157 T19157 ROOT activated,activated
R9594 T19158 T19157 agent by,activated
R9595 T19159 T19158 pobj IL-6,by
R9596 T19160 T19157 prep in,activated
R9597 T19161 T19165 amod normal,cells
R9598 T19162 T19165 nmod CD4,cells
R9599 T19163 T19165 nummod +,cells
R9600 T19164 T19165 compound T,cells
R9601 T19165 T19160 pobj cells,in
R9602 T19166 T19165 punct (,cells
R9603 T19167 T19177 nsubj data,[
R9604 T19168 T19169 neg not,shown
R9605 T19169 T19167 acl shown,data
R9606 T19170 T19167 punct ),data
R9607 T19171 T19177 punct ",",[
R9608 T19172 T19177 prep in,[
R9609 T19173 T19172 pobj agreement,in
R9610 T19174 T19173 prep with,agreement
R9611 T19175 T19176 amod previous,observations
R9612 T19176 T19174 pobj observations,with
R9613 T19177 T19157 advcl [,activated
R9614 T19178 T19179 nummod 4,]
R9615 T19179 T19177 dobj ],[
R9616 T19180 T19177 punct .,[
R9617 T19181 T19185 amod Normal,cells
R9618 T19182 T19185 compound CD4,cells
R9619 T19183 T19185 nummod +,cells
R9620 T19184 T19185 compound T,cells
R9621 T19185 T19188 nsubjpass cells,incubated
R9622 T19186 T19188 auxpass were,incubated
R9623 T19187 T19188 advmod thus,incubated
R9624 T19188 T19188 ROOT incubated,incubated
R9625 T19189 T19188 prep for,incubated
R9626 T19190 T19191 nummod 20,min
R9627 T19191 T19189 pobj min,for
R9628 T19192 T19191 prep with,min
R9629 T19193 T19194 compound culture,medium
R9630 T19194 T19195 nsubj medium,containing
R9631 T19195 T19192 pcomp containing,with
R9632 T19196 T19197 nummod 30,%
R9633 T19197 T19198 compound %,serum
R9634 T19198 T19195 dobj serum,containing
R9635 T19199 T19198 prep from,serum
R9636 T19200 T19202 amod active,patients
R9637 T19201 T19202 compound RA,patients
R9638 T19202 T19199 pobj patients,from
R9639 T19203 T19195 cc and,containing
R9640 T19204 T19195 conj neutralizing,containing
R9641 T19205 T19206 amod anti-IL-6,antibody
R9642 T19206 T19204 dobj antibody,neutralizing
R9643 T19207 T19206 cc or,antibody
R9644 T19208 T19209 compound control,antibody
R9645 T19209 T19206 conj antibody,antibody
R9646 T19210 T19204 punct ",",neutralizing
R9647 T19211 T19204 cc and,neutralizing
R9648 T19212 T19213 compound STAT,phosphorylation
R9649 T19213 T19215 nsubjpass phosphorylation,examined
R9650 T19214 T19215 auxpass was,examined
R9651 T19215 T19188 advcl examined,incubated
R9652 T19216 T19215 agent by,examined
R9653 T19217 T19219 amod western,analysis
R9654 T19218 T19219 compound blot,analysis
R9655 T19219 T19216 pobj analysis,by
R9656 T19220 T19215 punct .,examined
R9657 T19221 T19222 compound RA,serum
R9658 T19222 T19223 nsubj serum,was
R9659 T19223 T19223 ROOT was,was
R9660 T19224 T19223 acomp able,was
R9661 T19225 T19226 aux to,induce
R9662 T19226 T19224 xcomp induce,able
R9663 T19227 T19228 amod tyrosine,phosphorylation
R9664 T19228 T19226 dobj phosphorylation,induce
R9665 T19229 T19228 prep of,phosphorylation
R9666 T19230 T19229 pobj STAT3,of
R9667 T19231 T19230 cc but,STAT3
R9668 T19232 T19233 neg not,STAT1
R9669 T19233 T19241 nsubjpass STAT1,abolished
R9670 T19234 T19233 punct ",",STAT1
R9671 T19235 T19233 cc and,STAT1
R9672 T19236 T19238 det this,activation
R9673 T19237 T19238 nummod STAT3,activation
R9674 T19238 T19233 conj activation,STAT1
R9675 T19239 T19241 auxpass was,abolished
R9676 T19240 T19241 advmod mostly,abolished
R9677 T19241 T19223 advcl abolished,was
R9678 T19242 T19241 agent by,abolished
R9679 T19243 T19242 pobj neutralization,by
R9680 T19244 T19243 prep of,neutralization
R9681 T19245 T19246 compound IL-6,activity
R9682 T19246 T19244 pobj activity,of
R9683 T19247 T19241 punct (,abolished
R9684 T19248 T19249 compound Fig.,5a
R9685 T19249 T19241 npadvmod 5a,abolished
R9686 T19250 T19241 punct ),abolished
R9687 T19251 T19223 punct .,was
R9688 T19252 T19253 det These,results
R9689 T19253 T19254 nsubj results,indicate
R9690 T19254 T19254 ROOT indicate,indicate
R9691 T19255 T19257 mark that,is
R9692 T19256 T19257 nsubj IL-6,is
R9693 T19257 T19254 ccomp is,indicate
R9694 T19258 T19261 det the,factor
R9695 T19259 T19261 amod dominant,factor
R9696 T19260 T19261 amod STAT3-activating,factor
R9697 T19261 T19257 attr factor,is
R9698 T19262 T19261 acl contained,factor
R9699 T19263 T19262 prep in,contained
R9700 T19264 T19263 pobj sera,in
R9701 T19265 T19264 prep of,sera
R9702 T19266 T19268 amod active,patients
R9703 T19267 T19268 compound RA,patients
R9704 T19268 T19265 pobj patients,of
R9705 T19269 T19254 punct .,indicate
R9706 T19270 T19271 det The,lack
R9707 T19271 T19278 nsubj lack,suggests
R9708 T19272 T19271 prep of,lack
R9709 T19273 T19274 nummod STAT1,activation
R9710 T19274 T19272 pobj activation,of
R9711 T19275 T19274 prep by,activation
R9712 T19276 T19277 compound RA,serum
R9713 T19277 T19275 pobj serum,by
R9714 T19278 T19278 ROOT suggests,suggests
R9715 T19279 T19287 mark that,required
R9716 T19280 T19281 advmod much,higher
R9717 T19281 T19282 amod higher,concentrations
R9718 T19282 T19287 nsubjpass concentrations,required
R9719 T19283 T19282 prep of,concentrations
R9720 T19284 T19283 pobj IL-6,of
R9721 T19285 T19287 aux may,required
R9722 T19286 T19287 auxpass be,required
R9723 T19287 T19278 ccomp required,suggests
R9724 T19288 T19287 prep for,required
R9725 T19289 T19290 nummod STAT1,activation
R9726 T19290 T19288 pobj activation,for
R9727 T19291 T19290 prep as,activation
R9728 T19292 T19291 prep compared,as
R9729 T19293 T19292 prep with,compared
R9730 T19294 T19295 nummod STAT3,activation
R9731 T19295 T19293 pobj activation,with
R9732 T19296 T19295 punct ",",activation
R9733 T19297 T19295 cc or,activation
R9734 T19298 T19304 mark that,be
R9735 T19299 T19304 nsubj inhibitors,be
R9736 T19300 T19299 prep of,inhibitors
R9737 T19301 T19300 pobj STAT1,of
R9738 T19302 T19304 nsubj signaling,be
R9739 T19303 T19304 aux may,be
R9740 T19304 T19287 advcl be,required
R9741 T19305 T19304 acomp present,be
R9742 T19306 T19305 prep in,present
R9743 T19307 T19308 compound RA,serum
R9744 T19308 T19306 pobj serum,in
R9745 T19309 T19278 punct .,suggests
R9746 T19310 T19312 nsubj We,examined
R9747 T19311 T19312 advmod next,examined
R9748 T19312 T19312 ROOT examined,examined
R9749 T19313 T19316 mark whether,suppress
R9750 T19314 T19316 nsubj IL-6,suppress
R9751 T19315 T19316 aux could,suppress
R9752 T19316 T19312 ccomp suppress,examined
R9753 T19317 T19318 det the,effect
R9754 T19318 T19316 dobj effect,suppress
R9755 T19319 T19318 prep of,effect
R9756 T19320 T19319 pobj IL-10,of
R9757 T19321 T19322 aux to,inhibit
R9758 T19322 T19316 advcl inhibit,suppress
R9759 T19323 T19324 amod IFN-γ,production
R9760 T19324 T19322 dobj production,inhibit
R9761 T19325 T19324 prep by,production
R9762 T19326 T19329 compound CD4,cells
R9763 T19327 T19329 compound +,cells
R9764 T19328 T19329 compound T,cells
R9765 T19329 T19325 pobj cells,by
R9766 T19330 T19312 punct .,examined
R9767 T19331 T19349 prep After,stimulated
R9768 T19332 T19331 pobj preincubation,After
R9769 T19333 T19332 prep with,preincubation
R9770 T19334 T19333 cc or,with
R9771 T19335 T19333 conj without,with
R9772 T19336 T19337 nummod 10,ng/ml
R9773 T19337 T19338 compound ng/ml,IL-6
R9774 T19338 T19335 pobj IL-6,without
R9775 T19339 T19332 prep for,preincubation
R9776 T19340 T19341 nummod 36,hours
R9777 T19341 T19339 pobj hours,for
R9778 T19342 T19349 punct ",",stimulated
R9779 T19343 T19347 amod normal,cells
R9780 T19344 T19347 compound CD4,cells
R9781 T19345 T19347 nummod +,cells
R9782 T19346 T19347 compound T,cells
R9783 T19347 T19349 nsubjpass cells,stimulated
R9784 T19348 T19349 auxpass were,stimulated
R9785 T19349 T19349 ROOT stimulated,stimulated
R9786 T19350 T19349 agent by,stimulated
R9787 T19351 T19350 pobj CD3,by
R9788 T19352 T19351 cc and,CD3
R9789 T19353 T19354 compound CD28,costimulation
R9790 T19354 T19351 conj costimulation,CD3
R9791 T19355 T19354 prep in,costimulation
R9792 T19356 T19357 det the,presence
R9793 T19357 T19355 pobj presence,in
R9794 T19358 T19357 cc or,presence
R9795 T19359 T19357 conj absence,presence
R9796 T19360 T19357 prep of,presence
R9797 T19361 T19362 nummod 1,ng/ml
R9798 T19362 T19363 compound ng/ml,IL-10
R9799 T19363 T19360 pobj IL-10,of
R9800 T19364 T19354 prep for,costimulation
R9801 T19365 T19366 nummod 36,hours
R9802 T19366 T19364 pobj hours,for
R9803 T19367 T19354 punct ",",costimulation
R9804 T19368 T19354 cc and,costimulation
R9805 T19369 T19371 det the,production
R9806 T19370 T19371 compound IFN-γ,production
R9807 T19371 T19373 nsubjpass production,measured
R9808 T19372 T19373 auxpass was,measured
R9809 T19373 T19349 conj measured,stimulated
R9810 T19374 T19373 agent by,measured
R9811 T19375 T19374 pobj ELISA,by
R9812 T19376 T19373 punct .,measured
R9813 T19377 T19378 compound IL-6,pretreatment
R9814 T19378 T19382 nsubj pretreatment,reduced
R9815 T19379 T19378 prep of,pretreatment
R9816 T19380 T19381 amod normal,cells
R9817 T19381 T19379 pobj cells,of
R9818 T19382 T19382 ROOT reduced,reduced
R9819 T19383 T19384 amod IL-10-mediated,inhibition
R9820 T19384 T19382 dobj inhibition,reduced
R9821 T19385 T19384 prep of,inhibition
R9822 T19386 T19387 compound IFN-γ,production
R9823 T19387 T19385 pobj production,of
R9824 T19388 T19387 punct (,production
R9825 T19389 T19384 appos Fig.,inhibition
R9826 T19390 T19389 nummod 5b,Fig.
R9827 T19391 T19382 punct ),reduced
R9828 T19392 T19382 punct ",",reduced
R9829 T19393 T19382 advcl indicating,reduced
R9830 T19394 T19400 mark that,modulate
R9831 T19395 T19396 amod high,concentrations
R9832 T19396 T19400 nsubj concentrations,modulate
R9833 T19397 T19396 prep of,concentrations
R9834 T19398 T19397 pobj IL-6,of
R9835 T19399 T19400 aux could,modulate
R9836 T19400 T19393 ccomp modulate,indicating
R9837 T19401 T19402 compound T-cell,responsiveness
R9838 T19402 T19400 dobj responsiveness,modulate
R9839 T19403 T19402 prep to,responsiveness
R9840 T19404 T19403 pobj IL-10,to
R9841 T19405 T19382 punct .,reduced
R9842 T19406 T19411 advcl Taken,suggest
R9843 T19407 T19406 advmod together,Taken
R9844 T19408 T19411 punct ",",suggest
R9845 T19409 T19410 det these,findings
R9846 T19410 T19411 nsubj findings,suggest
R9847 T19411 T19411 ROOT suggest,suggest
R9848 T19412 T19419 mark that,have
R9849 T19413 T19414 amod persistent,exposure
R9850 T19414 T19419 nsubj exposure,have
R9851 T19415 T19416 aux to,serum
R9852 T19416 T19414 acl serum,exposure
R9853 T19417 T19416 dobj IL-6,serum
R9854 T19418 T19419 aux may,have
R9855 T19419 T19411 ccomp have,suggest
R9856 T19420 T19421 det a,role
R9857 T19421 T19419 dobj role,have
R9858 T19422 T19421 prep in,role
R9859 T19423 T19425 preconj both,induction
R9860 T19424 T19425 det the,induction
R9861 T19425 T19422 pobj induction,in
R9862 T19426 T19425 prep of,induction
R9863 T19427 T19428 nummod STAT3,activation
R9864 T19428 T19426 pobj activation,of
R9865 T19429 T19428 cc and,activation
R9866 T19430 T19431 det the,resistance
R9867 T19431 T19428 conj resistance,activation
R9868 T19432 T19431 prep to,resistance
R9869 T19433 T19435 det the,effect
R9870 T19434 T19435 amod inhibitory,effect
R9871 T19435 T19432 pobj effect,to
R9872 T19436 T19435 prep of,effect
R9873 T19437 T19436 pobj IL-10,of
R9874 T19438 T19435 prep in,effect
R9875 T19439 T19440 compound RA,CD4
R9876 T19440 T19438 pobj CD4,in
R9877 T19441 T19443 amod +,cells
R9878 T19442 T19443 compound T,cells
R9879 T19443 T19425 conj cells,induction
R9880 T19444 T19411 punct .,suggest