| Id |
Subject |
Object |
Predicate |
Lexical cue |
Negation |
Speculation |
| T950 |
13-20 |
Protein |
denotes |
SHARPIN |
|
|
| T951 |
150-159 |
Gene_expression |
denotes |
expressed |
|
|
| T952 |
212-231 |
Negative_regulation |
denotes |
recessive mutations |
|
|
| T953 |
239-246 |
Protein |
denotes |
Sharpin |
|
|
| T954 |
394-403 |
Positive_regulation |
denotes |
resulting |
|
|
| T955 |
394-403 |
Positive_regulation |
denotes |
resulting |
|
|
| T956 |
417-428 |
Negative_regulation |
denotes |
termination |
|
|
| T957 |
437-446 |
Transcription |
denotes |
synthesis |
|
|
| T958 |
451-458 |
Negative_regulation |
denotes |
absence |
|
|
| T959 |
1108-1117 |
Negative_regulation |
denotes |
decreased |
|
|
| T960 |
1118-1127 |
Gene_expression |
denotes |
secretion |
|
|
| T961 |
1131-1135 |
Protein |
denotes |
IFNγ |
|
|
| T962 |
1330-1344 |
Negative_regulation |
denotes |
Neutralization |
|
|
| T963 |
1348-1351 |
Protein |
denotes |
IL5 |
|
|
| T964 |
1390-1393 |
Protein |
denotes |
IL5 |
|
|
| T965 |
1394-1403 |
Negative_regulation |
denotes |
deficient |
|
|
| T966 |
1583-1590 |
Protein |
denotes |
SHARPIN |
|
|
| T967 |
1687-1691 |
Protein |
denotes |
TNFα |
|
|
| T968 |
1735-1742 |
Protein |
denotes |
SHARPIN |
|
|
| T969 |
1743-1752 |
Negative_regulation |
denotes |
deficient |
|
|
| T970 |
1805-1809 |
Protein |
denotes |
TNFα |
|
|
| T971 |
2457-2464 |
Protein |
denotes |
SHARPIN |
|
|
| T972 |
2465-2474 |
Negative_regulation |
denotes |
deficient |
|
|
| T973 |
2518-2522 |
Negative_regulation |
denotes |
lack |
|
|
| T974 |
2526-2533 |
Protein |
denotes |
SHARPIN |
|
|
| T975 |
2811-2818 |
Protein |
denotes |
SHARPIN |
|
|
| T976 |
2910-2917 |
Protein |
denotes |
SHARPIN |
|
|
| T977 |
2918-2927 |
Negative_regulation |
denotes |
deficient |
|
|
| T2199 |
2997-3004 |
Protein |
denotes |
Sharpin |
|
|
| T2200 |
3019-3026 |
Protein |
denotes |
SHARPIN |
|
|
| T2201 |
3178-3185 |
Protein |
denotes |
SHARPIN |
|
|
| T2202 |
3392-3399 |
Protein |
denotes |
SHARPIN |
|
|
| T2203 |
3456-3463 |
Protein |
denotes |
SHARPIN |
|
|
| T2204 |
3526-3535 |
Negative_regulation |
denotes |
mutations |
|
|
| T2205 |
3549-3556 |
Protein |
denotes |
Sharpin |
|
|
| T2206 |
3766-3776 |
Transcription |
denotes |
expression |
|
|
| T2207 |
3780-3787 |
Protein |
denotes |
Sharpin |
|
|
| T2208 |
3920-3927 |
Protein |
denotes |
Sharpin |
|
|
| T2209 |
3937-3944 |
Transcription |
denotes |
present |
|
|
| T2210 |
4013-4022 |
Negative_regulation |
denotes |
decreased |
|
|
| T2211 |
4067-4076 |
Negative_regulation |
denotes |
reduction |
|
|
| T2212 |
4080-4087 |
Protein |
denotes |
Sharpin |
|
|
| T2213 |
4166-4173 |
Protein |
denotes |
Sharpin |
|
|
| T2214 |
4235-4246 |
Entity |
denotes |
cytoplasmic |
|
|
| T2215 |
4247-4259 |
Localization |
denotes |
localization |
|
|
| T2216 |
4267-4274 |
Protein |
denotes |
SHARPIN |
|
|
| T12755 |
4371-4378 |
Protein |
denotes |
SHARPIN |
|
|
| T12756 |
4597-4604 |
Protein |
denotes |
SHARPIN |
|
|
| T12757 |
4958-4968 |
Transcription |
denotes |
mRNA level |
|
true |
| T12758 |
4972-4979 |
Protein |
denotes |
Sharpin |
|
|
| T12759 |
5249-5256 |
Protein |
denotes |
SHARPIN |
|
|
| T12760 |
5425-5432 |
Protein |
denotes |
SHARPIN |
|
|
| T12761 |
5449-5458 |
Entity |
denotes |
cytoplasm |
|
|
| T12762 |
5459-5468 |
Localization |
denotes |
localized |
|
|
| T3262 |
5643-5650 |
Protein |
denotes |
Sharpin |
|
|
| T3241 |
5651-5659 |
Negative_regulation |
denotes |
mutation |
|
|
| T3273 |
5778-5783 |
Protein |
denotes |
CD11c |
|
|
| T3274 |
5784-5788 |
Protein |
denotes |
CD8α |
|
|
| T3275 |
5794-5799 |
Protein |
denotes |
CD11c |
|
|
| T3280 |
5800-5804 |
Protein |
denotes |
CD8α |
|
|
| T3276 |
5838-5843 |
Protein |
denotes |
CD11c |
|
|
| T3277 |
5844-5850 |
Protein |
denotes |
PDCA-1 |
|
|
| T3278 |
6069-6076 |
Protein |
denotes |
SHARPIN |
|
|
| T3252 |
6077-6087 |
Negative_regulation |
denotes |
deficiency |
|
|
| T3279 |
6404-6411 |
Protein |
denotes |
Sharpin |
|
|
| T3255 |
6412-6420 |
Negative_regulation |
denotes |
mutation |
|
|
| T13263 |
6550-6557 |
Protein |
denotes |
Sharpin |
|
|
| T13264 |
6558-6566 |
Negative_regulation |
denotes |
mutation |
|
|
| T3263 |
8005-8010 |
Protein |
denotes |
CD11c |
|
|
| T3264 |
8072-8076 |
Protein |
denotes |
CD40 |
|
|
| T3265 |
8078-8082 |
Protein |
denotes |
CD80 |
|
|
| T3266 |
8088-8092 |
Protein |
denotes |
CD86 |
|
|
| T3267 |
8098-8102 |
Protein |
denotes |
TLR3 |
|
|
| T3256 |
8103-8109 |
Binding |
denotes |
ligand |
|
|
| T3268 |
8127-8131 |
Protein |
denotes |
TLR4 |
|
|
| T3257 |
8132-8138 |
Binding |
denotes |
ligand |
|
|
| T3242 |
8298-8306 |
Positive_regulation |
denotes |
resulted |
|
|
| T3258 |
8298-8306 |
Positive_regulation |
denotes |
resulted |
|
|
| T3260 |
8298-8306 |
Positive_regulation |
denotes |
resulted |
|
|
| T3243 |
8310-8319 |
Positive_regulation |
denotes |
increased |
|
|
| T3259 |
8310-8319 |
Positive_regulation |
denotes |
increased |
|
|
| T3261 |
8310-8319 |
Positive_regulation |
denotes |
increased |
|
|
| T3244 |
8320-8330 |
Gene_expression |
denotes |
expression |
|
|
| T3245 |
8320-8330 |
Gene_expression |
denotes |
expression |
|
|
| T3246 |
8320-8330 |
Gene_expression |
denotes |
expression |
|
|
| T3269 |
8334-8338 |
Protein |
denotes |
CD40 |
|
|
| T3270 |
8340-8344 |
Protein |
denotes |
CD80 |
|
|
| T3271 |
8350-8354 |
Protein |
denotes |
CD86 |
|
|
| T3247 |
8386-8396 |
Regulation |
denotes |
difference |
true |
|
| T3249 |
8386-8396 |
Regulation |
denotes |
difference |
true |
|
| T3251 |
8386-8396 |
Regulation |
denotes |
difference |
true |
|
| T3248 |
8404-8414 |
Gene_expression |
denotes |
expression |
|
|
| T3250 |
8404-8414 |
Gene_expression |
denotes |
expression |
|
|
| T3253 |
8404-8414 |
Gene_expression |
denotes |
expression |
|
|
| T3272 |
8481-8488 |
Protein |
denotes |
SHARPIN |
|
|
| T3254 |
8489-8499 |
Negative_regulation |
denotes |
deficiency |
|
|
| T3805 |
8668-8676 |
Positive_regulation |
denotes |
resulted |
|
|
| T3806 |
8668-8676 |
Positive_regulation |
denotes |
resulted |
|
|
| T3807 |
8680-8689 |
Gene_expression |
denotes |
secretion |
|
|
| T3808 |
8680-8689 |
Gene_expression |
denotes |
secretion |
|
|
| T3809 |
8693-8696 |
Protein |
denotes |
IL6 |
|
|
| T3810 |
8711-8716 |
Protein |
denotes |
GMCSF |
|
|
| T3811 |
8774-8782 |
Gene_expression |
denotes |
produced |
|
|
| T3812 |
8774-8782 |
Gene_expression |
denotes |
produced |
|
|
| T3813 |
8797-8801 |
Positive_regulation |
denotes |
less |
true |
|
| T3814 |
8797-8801 |
Positive_regulation |
denotes |
less |
true |
|
| T3815 |
9057-9064 |
Protein |
denotes |
Sharpin |
|
|
| T3816 |
9065-9074 |
Negative_regulation |
denotes |
deficient |
|
|
| T3817 |
9112-9119 |
Protein |
denotes |
Sharpin |
|
|
| T3818 |
9333-9340 |
Protein |
denotes |
SHARPIN |
|
|
| T3819 |
9437-9440 |
Protein |
denotes |
Il6 |
|
|
| T3820 |
9442-9449 |
Protein |
denotes |
Il12p40 |
|
|
| T3821 |
9451-9456 |
Protein |
denotes |
Gmcsf |
|
|
| T3822 |
9462-9466 |
Protein |
denotes |
Ifnb |
|
|
| T13802 |
9921-9924 |
Protein |
denotes |
IL6 |
|
|
| T13803 |
9930-9935 |
Protein |
denotes |
GMCSF |
|
|
| T13804 |
10154-10157 |
Protein |
denotes |
IL6 |
|
|
| T13805 |
10223-10230 |
Protein |
denotes |
Sharpin |
|
|
| T14248 |
10927-10937 |
Transcription |
denotes |
expression |
|
true |
| T14249 |
10927-10937 |
Transcription |
denotes |
expression |
|
true |
| T14250 |
10927-10937 |
Transcription |
denotes |
expression |
|
true |
| T14251 |
10927-10937 |
Transcription |
denotes |
expression |
|
true |
| T14252 |
10941-10948 |
Protein |
denotes |
Il12p40 |
|
|
| T14253 |
10956-10959 |
Protein |
denotes |
Il6 |
|
|
| T14254 |
10967-10972 |
Protein |
denotes |
Gmcsf |
|
|
| T14255 |
10984-10988 |
Protein |
denotes |
Ifnb |
|
|
| T4410 |
11607-11611 |
Protein |
denotes |
TLR4 |
|
|
| T4411 |
11636-11640 |
Protein |
denotes |
CD14 |
|
|
| T4412 |
11645-11677 |
Protein |
denotes |
myeloid differentiation factor 2 |
|
|
| T4413 |
11679-11682 |
Protein |
denotes |
MD2 |
|
|
| T4414 |
11683-11687 |
Protein |
denotes |
LY96 |
|
|
| T4415 |
11735-11745 |
Gene_expression |
denotes |
expression |
|
|
| T4416 |
11735-11745 |
Gene_expression |
denotes |
expression |
|
|
| T4417 |
11735-11745 |
Gene_expression |
denotes |
expression |
|
|
| T4418 |
11756-11760 |
Protein |
denotes |
CD14 |
|
|
| T4419 |
11765-11769 |
Protein |
denotes |
TLR4 |
|
|
| T4420 |
11770-11773 |
Protein |
denotes |
MD2 |
|
|
| T4421 |
11846-11855 |
Gene_expression |
denotes |
secretion |
|
true |
| T4422 |
11885-11889 |
Protein |
denotes |
IL10 |
|
|
| T4423 |
12028-12033 |
Positive_regulation |
denotes |
lower |
true |
|
| T4424 |
12034-12040 |
Gene_expression |
denotes |
levels |
|
|
| T4425 |
12044-12048 |
Protein |
denotes |
IL10 |
|
|
| T4426 |
12100-12104 |
Protein |
denotes |
IL10 |
|
|
| T4427 |
12174-12183 |
Positive_regulation |
denotes |
Increased |
|
|
| T4428 |
12184-12194 |
Gene_expression |
denotes |
expression |
|
|
| T4429 |
12244-12247 |
Protein |
denotes |
A20 |
|
|
| T4430 |
12304-12320 |
Transcription |
denotes |
transcript level |
|
|
| T4431 |
12324-12327 |
Protein |
denotes |
A20 |
|
|
| T4432 |
12332-12337 |
Positive_regulation |
denotes |
lower |
true |
|
| T4433 |
12412-12426 |
Positive_regulation |
denotes |
overexpression |
|
|
| T4434 |
12430-12433 |
Protein |
denotes |
A20 |
|
|
| T14565 |
12526-12532 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14566 |
12526-12532 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14567 |
12533-12537 |
Protein |
denotes |
TLR4 |
|
|
| T14568 |
12542-12545 |
Protein |
denotes |
MD2 |
|
|
| T14569 |
12546-12556 |
Gene_expression |
denotes |
expression |
|
|
| T14570 |
12546-12556 |
Gene_expression |
denotes |
expression |
|
|
| T14571 |
12561-12570 |
Negative_regulation |
denotes |
decreased |
|
|
| T14572 |
12561-12570 |
Negative_regulation |
denotes |
decreased |
|
|
| T14573 |
12571-12575 |
Protein |
denotes |
IL10 |
|
|
| T14574 |
12576-12585 |
Gene_expression |
denotes |
secretion |
|
|
| T14575 |
12590-12593 |
Protein |
denotes |
A20 |
|
|
| T14576 |
12594-12604 |
Gene_expression |
denotes |
expression |
|
|
| T14577 |
13006-13010 |
Protein |
denotes |
IL10 |
|
|
| T14578 |
13234-13244 |
Gene_expression |
denotes |
production |
|
true |
| T14579 |
13248-13251 |
Protein |
denotes |
A20 |
|
|
| T4435 |
13277-13281 |
Protein |
denotes |
TLR3 |
|
|
| T4436 |
13282-13283 |
Protein |
denotes |
4 |
|
|
| T4437 |
13396-13400 |
Protein |
denotes |
TBK1 |
|
|
| T4438 |
13401-13405 |
Protein |
denotes |
IRF3 |
|
|
| T4439 |
13466-13470 |
Protein |
denotes |
TBK1 |
|
|
| T4440 |
13471-13475 |
Protein |
denotes |
IRF3 |
|
|
| T4441 |
13561-13568 |
Protein |
denotes |
Sharpin |
|
|
| T4442 |
13569-13578 |
Negative_regulation |
denotes |
deficient |
|
|
| T4443 |
13637-13641 |
Protein |
denotes |
IKK1 |
|
|
| T4444 |
13642-13643 |
Protein |
denotes |
2 |
|
|
| T4445 |
13686-13694 |
Positive_regulation |
denotes |
allowing |
|
|
| T4446 |
13686-13694 |
Positive_regulation |
denotes |
allowing |
|
|
| T4447 |
13695-13710 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4448 |
13726-13734 |
Positive_regulation |
denotes |
mediated |
|
|
| T4449 |
13735-13746 |
Protein_catabolism |
denotes |
degradation |
|
|
| T4450 |
13770-13774 |
Protein |
denotes |
IκBα |
|
|
| T4451 |
13850-13864 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4452 |
13850-13864 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4453 |
13850-13864 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4454 |
13865-13869 |
Protein |
denotes |
IKK1 |
|
|
| T4455 |
13870-13871 |
Protein |
denotes |
2 |
|
|
| T4456 |
13875-13879 |
Protein |
denotes |
IKK1 |
|
|
| T4457 |
13880-13881 |
Protein |
denotes |
2 |
|
|
| T4458 |
13887-13891 |
Protein |
denotes |
IκBα |
|
|
| T4459 |
13895-13899 |
Protein |
denotes |
IκBα |
|
|
| T4460 |
13956-13965 |
Negative_regulation |
denotes |
decreased |
|
|
| T4461 |
13956-13965 |
Negative_regulation |
denotes |
decreased |
|
|
| T4462 |
13956-13965 |
Negative_regulation |
denotes |
decreased |
|
|
| T4463 |
14060-14064 |
Protein |
denotes |
TBK1 |
|
|
| T4464 |
14066-14070 |
Protein |
denotes |
ERK1 |
|
|
| T4465 |
14071-14072 |
Protein |
denotes |
2 |
|
|
| T4466 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4467 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4468 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4469 |
14161-14168 |
Negative_regulation |
denotes |
absence |
|
|
| T4470 |
14183-14190 |
Protein |
denotes |
SHARPIN |
|
|
| T4471 |
14237-14241 |
Protein |
denotes |
TBK1 |
|
|
| T4472 |
14242-14246 |
Protein |
denotes |
IRF3 |
|
|
| T4473 |
14248-14252 |
Protein |
denotes |
ERK1 |
|
|
| T4474 |
14253-14254 |
Protein |
denotes |
2 |
|
|
| T14985 |
14635-14639 |
Protein |
denotes |
TBK1 |
|
|
| T14986 |
14640-14644 |
Protein |
denotes |
IRF3 |
|
|
| T14987 |
14646-14650 |
Protein |
denotes |
ERK1 |
|
|
| T14988 |
14651-14652 |
Protein |
denotes |
2 |
|
|
| T14989 |
14682-14692 |
Protein |
denotes |
Beta-actin |
|
|
| T14990 |
14747-14751 |
Protein |
denotes |
IKK1 |
|
|
| T14991 |
14752-14753 |
Protein |
denotes |
2 |
|
|
| T14992 |
14760-14764 |
Protein |
denotes |
IκBα |
|
|
| T5789 |
15093-15100 |
Negative_regulation |
denotes |
absence |
|
|
| T5790 |
15104-15111 |
Protein |
denotes |
SHARPIN |
|
|
| T5791 |
15288-15296 |
Positive_regulation |
denotes |
elicited |
|
|
| T5792 |
15304-15308 |
Protein |
denotes |
IFNγ |
|
|
| T5793 |
15309-15319 |
Gene_expression |
denotes |
production |
|
|
| T5794 |
15333-15346 |
Gene_expression |
denotes |
concentration |
|
|
| T5795 |
15350-15354 |
Protein |
denotes |
IFNγ |
|
|
| T5796 |
15402-15407 |
Positive_regulation |
denotes |
lower |
true |
|
| T5797 |
15515-15519 |
Protein |
denotes |
TLR3 |
|
|
| T5798 |
15520-15521 |
Protein |
denotes |
4 |
|
|
| T5799 |
15522-15530 |
Positive_regulation |
denotes |
agonists |
|
|
| T5800 |
15522-15530 |
Positive_regulation |
denotes |
agonists |
|
|
| T5801 |
15536-15540 |
Protein |
denotes |
TLR2 |
|
|
| T5802 |
15541-15547 |
Binding |
denotes |
ligand |
|
|
| T5803 |
15548-15555 |
Protein |
denotes |
Pam3CYS |
|
|
| T5804 |
15637-15644 |
Protein |
denotes |
Pam3CYS |
|
|
| T5805 |
15661-15668 |
Positive_regulation |
denotes |
induced |
|
|
| T5806 |
15676-15680 |
Protein |
denotes |
IFNγ |
|
|
| T5807 |
15681-15691 |
Gene_expression |
denotes |
production |
|
|
| T5808 |
15792-15799 |
Protein |
denotes |
Pam3CYS |
|
|
| T5809 |
15908-15912 |
Protein |
denotes |
TLR2 |
|
|
| T5810 |
15962-15965 |
Protein |
denotes |
IL4 |
|
|
| T5811 |
15979-15987 |
Gene_expression |
denotes |
produced |
|
|
| T5812 |
16103-16113 |
Gene_expression |
denotes |
production |
|
|
| T5813 |
16140-16145 |
Protein |
denotes |
IL17A |
|
|
| T5814 |
16146-16155 |
Positive_regulation |
denotes |
following |
|
|
| T5815 |
16376-16379 |
Protein |
denotes |
IL2 |
|
|
| T5816 |
16380-16390 |
Gene_expression |
denotes |
production |
|
|
| T5817 |
16466-16473 |
Positive_regulation |
denotes |
induced |
|
|
| T5818 |
16474-16478 |
Positive_regulation |
denotes |
more |
|
|
| T5819 |
16479-16482 |
Protein |
denotes |
IL2 |
|
|
| T15325 |
17201-17210 |
Gene_expression |
denotes |
secretion |
|
true |
| T15326 |
17201-17210 |
Gene_expression |
denotes |
secretion |
|
true |
| T15327 |
17201-17210 |
Gene_expression |
denotes |
secretion |
|
true |
| T15328 |
17214-17218 |
Protein |
denotes |
IFNγ |
|
|
| T15329 |
17220-17223 |
Protein |
denotes |
IL4 |
|
|
| T15330 |
17229-17232 |
Protein |
denotes |
IL2 |
|
|
| T15331 |
17469-17479 |
Gene_expression |
denotes |
production |
true |
|
| T15332 |
17469-17479 |
Gene_expression |
denotes |
production |
true |
|
| T15333 |
17469-17479 |
Gene_expression |
denotes |
production |
true |
|
| T6683 |
17628-17642 |
Negative_regulation |
denotes |
null mutations |
|
|
| T6684 |
17656-17663 |
Protein |
denotes |
Sharpin |
|
|
| T6685 |
17788-17792 |
Negative_regulation |
denotes |
loss |
|
|
| T6686 |
17796-17803 |
Protein |
denotes |
SHARPIN |
|
|
| T6687 |
18271-18278 |
Protein |
denotes |
SHARPIN |
|
|
| T6688 |
18321-18331 |
Negative_regulation |
denotes |
disruption |
|
|
| T6689 |
18992-18996 |
Protein |
denotes |
TNFα |
|
|
| T6690 |
19067-19075 |
Negative_regulation |
denotes |
deletion |
|
|
| T6691 |
19079-19082 |
Protein |
denotes |
TNF |
|
|
| T6692 |
19109-19119 |
Negative_regulation |
denotes |
deficiency |
|
|
| T6693 |
19123-19130 |
Protein |
denotes |
SHARPIN |
|
|
| T6694 |
19601-19606 |
Protein |
denotes |
HMGB1 |
|
|
| T6695 |
19607-19617 |
Binding |
denotes |
recognized |
|
|
| T6696 |
19621-19625 |
Protein |
denotes |
TLR2 |
|
|
| T6697 |
19626-19627 |
Protein |
denotes |
4 |
|
|
| T6698 |
20134-20141 |
Protein |
denotes |
IL12P35 |
|
|
| T6699 |
20147-20154 |
Protein |
denotes |
IL12P40 |
|
|
| T6700 |
20155-20164 |
Negative_regulation |
denotes |
deficient |
|
|
| T6701 |
20155-20164 |
Negative_regulation |
denotes |
deficient |
|
|
| T6702 |
20250-20254 |
Protein |
denotes |
IRF3 |
|
|
| T6703 |
20516-20526 |
Positive_regulation |
denotes |
activation |
|
|
| T6704 |
20516-20526 |
Positive_regulation |
denotes |
activation |
|
|
| T6705 |
20516-20526 |
Positive_regulation |
denotes |
activation |
|
|
| T6706 |
20516-20526 |
Positive_regulation |
denotes |
activation |
|
|
| T6707 |
20530-20534 |
Protein |
denotes |
TBK1 |
|
|
| T6708 |
20535-20539 |
Protein |
denotes |
IRF3 |
|
|
| T6709 |
20541-20545 |
Protein |
denotes |
ERK1 |
|
|
| T6710 |
20546-20547 |
Protein |
denotes |
2 |
|
|
| T6711 |
20556-20563 |
Negative_regulation |
denotes |
was not |
true |
|
| T6712 |
20556-20563 |
Negative_regulation |
denotes |
was not |
true |
|
| T6713 |
20556-20563 |
Negative_regulation |
denotes |
was not |
true |
|
| T6714 |
20556-20563 |
Negative_regulation |
denotes |
was not |
true |
|
| T6715 |
20972-20979 |
Protein |
denotes |
SHARPIN |
|
|
| T6716 |
21134-21137 |
Protein |
denotes |
A20 |
|
|
| T6717 |
21142-21146 |
Protein |
denotes |
ITCH |
|
|
| T6718 |
21737-21745 |
Negative_regulation |
denotes |
deletion |
|
|
| T6719 |
21749-21756 |
Protein |
denotes |
Sharpin |
|
|
| T6720 |
21814-21821 |
Protein |
denotes |
SHARPIN |
|
|
| T6721 |
21881-21888 |
Negative_regulation |
denotes |
absence |
|
|
| T6722 |
21892-21899 |
Protein |
denotes |
Sharpin |
|
|
| T6723 |
21900-21910 |
Gene_expression |
denotes |
expression |
|
|
| T6724 |
22252-22256 |
Protein |
denotes |
p100 |
|
|
| T6725 |
22279-22282 |
Protein |
denotes |
p52 |
|
|
| T6726 |
22308-22315 |
Protein |
denotes |
SHARPIN |
|
|
| T6727 |
22316-22325 |
Negative_regulation |
denotes |
deficient |
|
|
| T6728 |
22379-22382 |
Protein |
denotes |
p52 |
|
|
| T6729 |
22383-22387 |
Protein |
denotes |
RELB |
|
|
| T6730 |
22503-22510 |
Protein |
denotes |
Sharpin |
|
|
| T6731 |
22511-22519 |
Negative_regulation |
denotes |
mutation |
|
|
| T6732 |
22656-22662 |
Binding |
denotes |
engage |
|
|
| T6733 |
22656-22662 |
Binding |
denotes |
engage |
|
|
| T6734 |
22663-22667 |
Protein |
denotes |
TLR4 |
|
|
| T6735 |
22672-22676 |
Protein |
denotes |
TLR3 |
|
|
| T6736 |
22888-22895 |
Binding |
denotes |
engages |
|
|
| T6737 |
22896-22900 |
Protein |
denotes |
TLR4 |
|
|
| T6738 |
22913-22918 |
Protein |
denotes |
MYD88 |
|
|
| T6739 |
22933-22937 |
Protein |
denotes |
TRIF |
|
|
| T6740 |
22966-22970 |
Protein |
denotes |
TLR3 |
|
|
| T6741 |
22971-22981 |
Positive_regulation |
denotes |
stimulated |
|
|
| T6742 |
23008-23012 |
Protein |
denotes |
TRIF |
|
|
| T6743 |
23104-23111 |
Protein |
denotes |
Sharpin |
|
|
| T6744 |
23112-23120 |
Negative_regulation |
denotes |
mutation |
|
|
| T6745 |
23212-23216 |
Protein |
denotes |
RIP1 |
|
|
| T6746 |
23221-23226 |
Protein |
denotes |
TRAF6 |
|
|
| T6747 |
23266-23273 |
Protein |
denotes |
SHARPIN |
|
|
| T6748 |
23274-23283 |
Binding |
denotes |
interacts |
|
|
| T6749 |
23289-23293 |
Protein |
denotes |
HOIP |
|
|
| T6750 |
23313-23319 |
Positive_regulation |
denotes |
exerts |
|
|
| T6751 |
23313-23319 |
Positive_regulation |
denotes |
exerts |
|
|
| T6752 |
23324-23362 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T6753 |
23324-23362 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T6754 |
23390-23394 |
Protein |
denotes |
RIP1 |
|
|
| T6755 |
23399-23403 |
Protein |
denotes |
NEMO |
|
|
| T6756 |
23438-23442 |
Protein |
denotes |
TNFα |
|
|
| T6757 |
23476-23483 |
Protein |
denotes |
Sharpin |
|
|
| T6758 |
23484-23497 |
Negative_regulation |
denotes |
null mutation |
|
|
| T6759 |
23498-23506 |
Negative_regulation |
denotes |
disrupts |
|
|
| T6760 |
23498-23506 |
Negative_regulation |
denotes |
disrupts |
|
|
| T6761 |
23552-23556 |
Protein |
denotes |
TNFα |
|
|
| T6762 |
23720-23727 |
Protein |
denotes |
SHARPIN |
|
|
| T6763 |
23841-23848 |
Protein |
denotes |
SHARPIN |
|
|
| T6764 |
23970-23977 |
Protein |
denotes |
Sharpin |
|
|
| T6765 |
23978-23987 |
Negative_regulation |
denotes |
deficient |
|
|
| T9628 |
25077-25084 |
Protein |
denotes |
Sharpin |
|
|
| T9953 |
25475-25482 |
Protein |
denotes |
Sharpin |
|
|
| T9954 |
25675-25682 |
Protein |
denotes |
Sharpin |
|
|
| T9955 |
25788-25795 |
Gene_expression |
denotes |
express |
|
|
| T9956 |
25808-25815 |
Protein |
denotes |
SHARPIN |
|
|
| T9957 |
25947-25954 |
Protein |
denotes |
SHARPIN |
|
|
| T9958 |
26138-26145 |
Protein |
denotes |
SHARPIN |
|
|
| T9959 |
26146-26156 |
Gene_expression |
denotes |
expression |
|
true |
| T10948 |
28168-28177 |
Gene_expression |
denotes |
secretion |
|
true |
| T10949 |
28168-28177 |
Gene_expression |
denotes |
secretion |
|
true |
| T10950 |
28168-28177 |
Gene_expression |
denotes |
secretion |
|
true |
| T10951 |
28168-28177 |
Gene_expression |
denotes |
secretion |
|
true |
| T10952 |
28181-28185 |
Protein |
denotes |
IFNγ |
|
|
| T10953 |
28187-28190 |
Protein |
denotes |
IL4 |
|
|
| T10954 |
28192-28195 |
Protein |
denotes |
IL2 |
|
|
| T10955 |
28201-28206 |
Protein |
denotes |
IL17A |
|
|
| T10956 |
28415-28425 |
Gene_expression |
denotes |
production |
true |
|
| T10957 |
28415-28425 |
Gene_expression |
denotes |
production |
true |
|
| T10958 |
28415-28425 |
Gene_expression |
denotes |
production |
true |
|
| T10959 |
28415-28425 |
Gene_expression |
denotes |
production |
true |
|
| T11335 |
28731-28741 |
Transcription |
denotes |
expression |
|
true |
| T11336 |
28731-28741 |
Transcription |
denotes |
expression |
|
true |
| T11337 |
28731-28741 |
Transcription |
denotes |
expression |
|
true |
| T11338 |
28731-28741 |
Transcription |
denotes |
expression |
|
true |
| T11339 |
28745-28748 |
Protein |
denotes |
Il6 |
|
|
| T11340 |
28750-28757 |
Protein |
denotes |
Il12p40 |
|
|
| T11341 |
28759-28764 |
Protein |
denotes |
Gmcsf |
|
|
| T11342 |
28770-28777 |
Protein |
denotes |
Sharpin |
|
|
| T11343 |
29098-29125 |
Protein |
denotes |
M-MLV Reverse Transcriptase |
|
|
| T11344 |
29460-29464 |
Protein |
denotes |
Actb |
|
|
| T11345 |
29466-29469 |
Protein |
denotes |
IL6 |
|
|
| T11346 |
29471-29478 |
Protein |
denotes |
IL12p40 |
|
|
| T11347 |
29480-29484 |
Protein |
denotes |
Ifnβ |
|
|
| T11348 |
29486-29491 |
Protein |
denotes |
Gmcsf |
|
|
| T11349 |
29497-29504 |
Protein |
denotes |
Sharpin |
|
|
| T11350 |
29612-29619 |
Protein |
denotes |
β-actin |
|
|
| T12082 |
30175-30182 |
Protein |
denotes |
SHARPIN |
|
|
| T12372 |
31018-31022 |
Protein |
denotes |
IKK1 |
|
|
| T12373 |
31023-31024 |
Protein |
denotes |
2 |
|
|
| T12374 |
31035-31039 |
Protein |
denotes |
IκBα |
|
|
| T12375 |
31049-31053 |
Protein |
denotes |
IκBα |
|
|
| T12376 |
31065-31069 |
Protein |
denotes |
TBK1 |
|
|
| T12377 |
31108-31112 |
Protein |
denotes |
ERK1 |
|
|
| T12378 |
31113-31114 |
Protein |
denotes |
2 |
|
|
| T12379 |
31128-31132 |
Protein |
denotes |
ERK1 |
|
|
| T12380 |
31133-31134 |
Protein |
denotes |
2 |
|
|
| T12381 |
31144-31154 |
Protein |
denotes |
Beta-actin |
|
|
| R10555 |
T12758 |
T12757 |
themeOf |
Sharpin,mRNA level |
| R10556 |
T12760 |
T12762 |
themeOf |
SHARPIN,localized |
| R10557 |
T12761 |
T12762 |
locationOf |
cytoplasm,localized |
| R11006 |
T13263 |
T13264 |
themeOf |
Sharpin,mutation |
| R11899 |
T14252 |
T14251 |
themeOf |
Il12p40,expression |
| R11900 |
T14253 |
T14250 |
themeOf |
Il6,expression |
| R11901 |
T14254 |
T14249 |
themeOf |
Gmcsf,expression |
| R11902 |
T14255 |
T14248 |
themeOf |
Ifnb,expression |
| R12179 |
T14567 |
T14570 |
themeOf |
TLR4,expression |
| R12180 |
T14568 |
T14569 |
themeOf |
MD2,expression |
| R12181 |
T14569 |
T14566 |
themeOf |
expression,Normal |
| R12182 |
T14570 |
T14565 |
themeOf |
expression,Normal |
| R12183 |
T14573 |
T14574 |
themeOf |
IL10,secretion |
| R12184 |
T14574 |
T14571 |
themeOf |
secretion,decreased |
| R12185 |
T14575 |
T14576 |
themeOf |
A20,expression |
| R12186 |
T14576 |
T14572 |
themeOf |
expression,decreased |
| R12187 |
T14579 |
T14578 |
themeOf |
A20,production |
| R12800 |
T15328 |
T15327 |
themeOf |
IFNγ,secretion |
| R12801 |
T15328 |
T15331 |
themeOf |
IFNγ,production |
| R12802 |
T15329 |
T15325 |
themeOf |
IL4,secretion |
| R12803 |
T15329 |
T15332 |
themeOf |
IL4,production |
| R12804 |
T15330 |
T15333 |
themeOf |
IL2,production |
| R12805 |
T15330 |
T15326 |
themeOf |
IL2,secretion |
| R1799 |
T2205 |
T2204 |
themeOf |
Sharpin,mutations |
| R1800 |
T2207 |
T2206 |
themeOf |
Sharpin,expression |
| R1801 |
T2208 |
T2209 |
themeOf |
Sharpin,present |
| R1802 |
T2209 |
T2210 |
themeOf |
present,decreased |
| R1803 |
T2212 |
T2211 |
themeOf |
Sharpin,reduction |
| R1804 |
T2214 |
T2215 |
locationOf |
cytoplasmic,localization |
| R1805 |
T2216 |
T2215 |
themeOf |
SHARPIN,localization |
| R2686 |
T3243 |
T3242 |
themeOf |
increased,resulted |
| R2687 |
T3244 |
T3259 |
themeOf |
expression,increased |
| R2688 |
T3245 |
T3261 |
themeOf |
expression,increased |
| R2689 |
T3246 |
T3243 |
themeOf |
expression,increased |
| R2690 |
T3248 |
T3247 |
themeOf |
expression,difference |
| R2691 |
T3250 |
T3249 |
themeOf |
expression,difference |
| R2692 |
T3253 |
T3251 |
themeOf |
expression,difference |
| R2693 |
T3259 |
T3258 |
themeOf |
increased,resulted |
| R2694 |
T3261 |
T3260 |
themeOf |
increased,resulted |
| R2695 |
T3262 |
T3241 |
themeOf |
Sharpin,mutation |
| R2696 |
T3267 |
T3256 |
themeOf |
TLR3,ligand |
| R2697 |
T3268 |
T3257 |
themeOf |
TLR4,ligand |
| R2698 |
T3269 |
T3244 |
themeOf |
CD40,expression |
| R2699 |
T3269 |
T3248 |
themeOf |
CD40,expression |
| R2700 |
T3270 |
T3245 |
themeOf |
CD80,expression |
| R2701 |
T3270 |
T3250 |
themeOf |
CD80,expression |
| R2702 |
T3271 |
T3246 |
themeOf |
CD86,expression |
| R2703 |
T3271 |
T3253 |
themeOf |
CD86,expression |
| R2704 |
T3272 |
T3254 |
themeOf |
SHARPIN,deficiency |
| R2705 |
T3278 |
T3252 |
themeOf |
SHARPIN,deficiency |
| R2706 |
T3279 |
T3255 |
themeOf |
Sharpin,mutation |
| R3126 |
T3807 |
T3806 |
themeOf |
secretion,resulted |
| R3127 |
T3808 |
T3805 |
themeOf |
secretion,resulted |
| R3128 |
T3809 |
T3808 |
themeOf |
IL6,secretion |
| R3129 |
T3809 |
T3811 |
themeOf |
IL6,produced |
| R3130 |
T3810 |
T3807 |
themeOf |
GMCSF,secretion |
| R3131 |
T3810 |
T3812 |
themeOf |
GMCSF,produced |
| R3132 |
T3811 |
T3813 |
themeOf |
produced,less |
| R3133 |
T3812 |
T3814 |
themeOf |
produced,less |
| R3134 |
T3815 |
T3816 |
themeOf |
Sharpin,deficient |
| R3595 |
T4413 |
T4412 |
equivalentTo |
MD2,myeloid differentiation factor 2 |
| R3596 |
T4414 |
T4412 |
equivalentTo |
LY96,myeloid differentiation factor 2 |
| R3597 |
T4418 |
T4416 |
themeOf |
CD14,expression |
| R3598 |
T4419 |
T4417 |
themeOf |
TLR4,expression |
| R3599 |
T4420 |
T4415 |
themeOf |
MD2,expression |
| R3600 |
T4422 |
T4421 |
themeOf |
IL10,secretion |
| R3601 |
T4424 |
T4423 |
themeOf |
levels,lower |
| R3602 |
T4425 |
T4424 |
themeOf |
IL10,levels |
| R3603 |
T4428 |
T4427 |
themeOf |
expression,Increased |
| R3604 |
T4429 |
T4428 |
themeOf |
A20,expression |
| R3605 |
T4430 |
T4432 |
themeOf |
transcript level,lower |
| R3606 |
T4431 |
T4430 |
themeOf |
A20,transcript level |
| R3607 |
T4434 |
T4433 |
themeOf |
A20,overexpression |
| R3608 |
T4441 |
T4442 |
themeOf |
Sharpin,deficient |
| R3609 |
T4447 |
T4446 |
themeOf |
phosphorylation,allowing |
| R3610 |
T4449 |
T4445 |
themeOf |
degradation,allowing |
| R3611 |
T4449 |
T4448 |
themeOf |
degradation,mediated |
| R3612 |
T4450 |
T4447 |
themeOf |
IκBα,phosphorylation |
| R3613 |
T4450 |
T4449 |
themeOf |
IκBα,degradation |
| R3614 |
T4451 |
T4460 |
themeOf |
phosphorylated,decreased |
| R3615 |
T4452 |
T4462 |
themeOf |
phosphorylated,decreased |
| R3616 |
T4453 |
T4461 |
themeOf |
phosphorylated,decreased |
| R3617 |
T4454 |
T4452 |
themeOf |
IKK1,phosphorylated |
| R3618 |
T4455 |
T4451 |
themeOf |
2,phosphorylated |
| R3619 |
T4458 |
T4453 |
themeOf |
IκBα,phosphorylated |
| R3620 |
T4463 |
T4468 |
themeOf |
TBK1,phosphorylation |
| R3621 |
T4464 |
T4466 |
themeOf |
ERK1,phosphorylation |
| R3622 |
T4465 |
T4467 |
themeOf |
2,phosphorylation |
| R3623 |
T4470 |
T4469 |
themeOf |
SHARPIN,absence |
| R4633 |
T5790 |
T5789 |
themeOf |
SHARPIN,absence |
| R4634 |
T5792 |
T5793 |
themeOf |
IFNγ,production |
| R4635 |
T5793 |
T5791 |
themeOf |
production,elicited |
| R4636 |
T5794 |
T5796 |
themeOf |
concentration,lower |
| R4637 |
T5795 |
T5794 |
themeOf |
IFNγ,concentration |
| R4638 |
T5797 |
T5800 |
themeOf |
TLR3,agonists |
| R4639 |
T5798 |
T5799 |
themeOf |
4,agonists |
| R4640 |
T5801 |
T5802 |
themeOf |
TLR2,ligand |
| R4641 |
T5803 |
T5802 |
themeOf |
Pam3CYS,ligand |
| R4642 |
T5804 |
T5805 |
causeOf |
Pam3CYS,induced |
| R4643 |
T5806 |
T5807 |
themeOf |
IFNγ,production |
| R4644 |
T5807 |
T5805 |
themeOf |
production,induced |
| R4645 |
T5810 |
T5811 |
themeOf |
IL4,produced |
| R4646 |
T5812 |
T5814 |
themeOf |
production,following |
| R4647 |
T5813 |
T5812 |
themeOf |
IL17A,production |
| R4648 |
T5815 |
T5816 |
themeOf |
IL2,production |
| R4649 |
T5817 |
T5818 |
themeOf |
induced,more |
| R4650 |
T5819 |
T5817 |
themeOf |
IL2,induced |
| R5370 |
T6684 |
T6683 |
themeOf |
Sharpin,null mutations |
| R5371 |
T6686 |
T6685 |
themeOf |
SHARPIN,loss |
| R5372 |
T6687 |
T6688 |
themeOf |
SHARPIN,disruption |
| R5373 |
T6691 |
T6690 |
themeOf |
TNF,deletion |
| R5374 |
T6693 |
T6692 |
themeOf |
SHARPIN,deficiency |
| R5375 |
T6694 |
T6695 |
themeOf |
HMGB1,recognized |
| R5376 |
T6696 |
T6695 |
themeOf |
TLR2,recognized |
| R5377 |
T6698 |
T6701 |
themeOf |
IL12P35,deficient |
| R5378 |
T6699 |
T6700 |
themeOf |
IL12P40,deficient |
| R5379 |
T6703 |
T6712 |
themeOf |
activation,was not |
| R5380 |
T6704 |
T6714 |
themeOf |
activation,was not |
| R5381 |
T6705 |
T6711 |
themeOf |
activation,was not |
| R5382 |
T6706 |
T6713 |
themeOf |
activation,was not |
| R5383 |
T6707 |
T6706 |
themeOf |
TBK1,activation |
| R5384 |
T6708 |
T6705 |
themeOf |
IRF3,activation |
| R5385 |
T6709 |
T6703 |
themeOf |
ERK1,activation |
| R5386 |
T6710 |
T6704 |
themeOf |
2,activation |
| R5387 |
T6719 |
T6718 |
themeOf |
Sharpin,deletion |
| R5388 |
T6722 |
T6723 |
themeOf |
Sharpin,expression |
| R5389 |
T6723 |
T6721 |
themeOf |
expression,absence |
| R5390 |
T6726 |
T6727 |
themeOf |
SHARPIN,deficient |
| R5391 |
T6730 |
T6731 |
themeOf |
Sharpin,mutation |
| R5392 |
T6734 |
T6732 |
themeOf |
TLR4,engage |
| R5393 |
T6735 |
T6733 |
themeOf |
TLR3,engage |
| R5394 |
T6737 |
T6736 |
themeOf |
TLR4,engages |
| R5395 |
T6740 |
T6741 |
themeOf |
TLR3,stimulated |
| R5396 |
T6743 |
T6744 |
themeOf |
Sharpin,mutation |
| R5397 |
T6747 |
T6748 |
themeOf |
SHARPIN,interacts |
| R5398 |
T6747 |
T6752 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R5399 |
T6747 |
T6753 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R5400 |
T6749 |
T6748 |
themeOf |
HOIP,interacts |
| R5401 |
T6752 |
T6751 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R5402 |
T6752 |
T6759 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R5403 |
T6753 |
T6750 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R5404 |
T6753 |
T6760 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R5405 |
T6754 |
T6752 |
themeOf |
RIP1,linear-ubiquitin-chain-ligase activity |
| R5406 |
T6755 |
T6753 |
themeOf |
NEMO,linear-ubiquitin-chain-ligase activity |
| R5407 |
T6757 |
T6758 |
themeOf |
Sharpin,null mutation |
| R5408 |
T6758 |
T6759 |
causeOf |
null mutation,disrupts |
| R5409 |
T6758 |
T6760 |
causeOf |
null mutation,disrupts |
| R5410 |
T6764 |
T6765 |
themeOf |
Sharpin,deficient |
| R740 |
T950 |
T951 |
themeOf |
SHARPIN,expressed |
| R741 |
T952 |
T955 |
causeOf |
recessive mutations,resulting |
| R742 |
T952 |
T954 |
causeOf |
recessive mutations,resulting |
| R743 |
T953 |
T958 |
themeOf |
Sharpin,absence |
| R744 |
T953 |
T957 |
themeOf |
Sharpin,synthesis |
| R745 |
T953 |
T952 |
themeOf |
Sharpin,recessive mutations |
| R746 |
T956 |
T954 |
themeOf |
termination,resulting |
| R747 |
T957 |
T956 |
themeOf |
synthesis,termination |
| R748 |
T958 |
T955 |
themeOf |
absence,resulting |
| R749 |
T960 |
T959 |
themeOf |
secretion,decreased |
| R750 |
T961 |
T960 |
themeOf |
IFNγ,secretion |
| R751 |
T963 |
T962 |
themeOf |
IL5,Neutralization |
| R752 |
T964 |
T965 |
themeOf |
IL5,deficient |
| R753 |
T968 |
T969 |
themeOf |
SHARPIN,deficient |
| R754 |
T971 |
T972 |
themeOf |
SHARPIN,deficient |
| R755 |
T974 |
T973 |
themeOf |
SHARPIN,lack |
| R756 |
T976 |
T977 |
themeOf |
SHARPIN,deficient |
| R8182 |
T9956 |
T9955 |
themeOf |
SHARPIN,express |
| R8183 |
T9958 |
T9959 |
themeOf |
SHARPIN,expression |
| R9073 |
T10952 |
T10956 |
themeOf |
IFNγ,production |
| R9074 |
T10952 |
T10951 |
themeOf |
IFNγ,secretion |
| R9075 |
T10953 |
T10957 |
themeOf |
IL4,production |
| R9076 |
T10953 |
T10950 |
themeOf |
IL4,secretion |
| R9077 |
T10954 |
T10958 |
themeOf |
IL2,production |
| R9078 |
T10954 |
T10948 |
themeOf |
IL2,secretion |
| R9079 |
T10955 |
T10959 |
themeOf |
IL17A,production |
| R9080 |
T10955 |
T10949 |
themeOf |
IL17A,secretion |
| R9392 |
T11339 |
T11338 |
themeOf |
Il6,expression |
| R9393 |
T11340 |
T11337 |
themeOf |
Il12p40,expression |
| R9394 |
T11341 |
T11336 |
themeOf |
Gmcsf,expression |
| R9395 |
T11342 |
T11335 |
themeOf |
Sharpin,expression |
