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PMC:2664230 / 2099-25061 JSONTXT 21 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Negation Speculation
T1126 459-468 Regulation denotes regulator
T1127 472-495 Protein denotes tumor necrosis factor-α
T1128 497-502 Protein denotes TNF-α
T1129 504-514 Gene_expression denotes production
T1130 517-522 Protein denotes TNF-α
T1131 625-630 Protein denotes TNF-α
T1132 631-640 Gene_expression denotes synthesis
T1133 648-658 Negative_regulation denotes attenuated
T1134 853-857 Positive_regulation denotes lead
T1135 865-879 Negative_regulation denotes downregulation
T1136 883-888 Protein denotes TNF-α
T1137 889-899 Gene_expression denotes production
T1138 1927-1934 Negative_regulation denotes inhibit
T1139 1941-1950 Regulation denotes dependent
T1140 1973-1986 Transcription denotes transcription
T1141 2008-2013 Protein denotes TNF-α
T1142 2097-2111 Negative_regulation denotes down-regulates
T1143 2112-2117 Protein denotes TNF-α
T1144 2118-2128 Gene_expression denotes production
T1145 2776-2780 Regulation denotes role true
T1146 2795-2802 Positive_regulation denotes induced
T1147 2803-2808 Protein denotes TNF-α
T1148 2809-2819 Gene_expression denotes production
T2441 3568-3582 Phosphorylation denotes phosphorylated
T2442 3583-3587 Protein denotes CREB
T2443 3589-3599 Entity denotes serine 133
T2444 3602-3616 Phosphorylation denotes phosphorylated
T2445 3602-3616 Phosphorylation denotes phosphorylated
T2446 3617-3622 Protein denotes I-κBα
T2447 3624-3634 Entity denotes serines 32
T2448 3639-3641 Entity denotes 36
T2449 3644-3658 Phosphorylation denotes phosphorylated
T2450 3665-3668 Protein denotes p65
T2451 3678-3688 Entity denotes serine 276
T2452 3913-3918 Protein denotes TNF-α
T3248 6118-6125 Positive_regulation denotes induced
T3249 6126-6131 Protein denotes TNF-α
T3250 6132-6142 Gene_expression denotes production
T3251 6295-6308 Positive_regulation denotes up-regulation
T3252 6313-6328 Negative_regulation denotes down-regulation
T3253 6332-6337 Protein denotes TNF-α
T3254 6338-6348 Gene_expression denotes production
T3964 6427-6434 Positive_regulation denotes induced
T3965 6435-6440 Protein denotes TNF-α
T3966 6441-6451 Gene_expression denotes production
T3967 6494-6499 Protein denotes TNF-α
T4131 6741-6746 Protein denotes I-κBα
T4132 6754-6757 Protein denotes p65
T4133 6763-6767 Protein denotes CREB
T4134 7730-7744 Phosphorylation denotes phosphorylated
T4135 7745-7750 Protein denotes I-κBα
T4136 7819-7833 Phosphorylation denotes phosphorylated
T4137 7840-7843 Protein denotes p65
T5622 10429-10433 Regulation denotes Role
T5623 10448-10455 Positive_regulation denotes induced
T5624 10473-10478 Protein denotes TNF-α
T5625 10479-10489 Gene_expression denotes production
T5626 10506-10510 Regulation denotes role
T5627 10521-10526 Protein denotes TNF-α
T5628 10527-10537 Gene_expression denotes production
T5629 10567-10578 Regulation denotes involvement
T5630 10586-10597 Negative_regulation denotes attenuation
T5631 10605-10612 Positive_regulation denotes induced
T5632 10613-10618 Protein denotes TNF-α
T5633 10619-10629 Gene_expression denotes production
T5634 11205-11210 Protein denotes TNF-α
T6229 11760-11767 Regulation denotes effects true
T6230 11782-11789 Positive_regulation denotes induced
T6231 11790-11795 Protein denotes TNF-α
T6232 11796-11806 Gene_expression denotes production
T6233 11854-11859 Protein denotes TNF-α
T6234 11860-11870 Gene_expression denotes production
T6235 11881-11892 Positive_regulation denotes stimulation
T6236 11991-11997 Regulation denotes effect
T6237 12001-12006 Protein denotes TNF-α
T6238 12007-12017 Gene_expression denotes production
T6476 12105-12110 Positive_regulation denotes leads
T6477 12133-12144 Protein_catabolism denotes degradation
T6478 12148-12153 Protein denotes I-κBα
T6479 12223-12230 Regulation denotes effects true
T6480 12241-12246 Protein denotes I-κBα
T6481 12260-12265 Protein denotes I-κBα
T6482 12266-12281 Phosphorylation denotes phosphorylation
T6483 12295-12304 Positive_regulation denotes increased
T6484 12305-12314 Positive_regulation denotes following
T6485 12423-12436 Negative_regulation denotes downregulated
T6486 12441-12448 Positive_regulation denotes induced
T6487 12449-12454 Protein denotes I-κBα
T6488 12455-12470 Phosphorylation denotes phosphorylation
T6489 12528-12531 Protein denotes p65
T6490 12532-12547 Phosphorylation denotes phosphorylation
T6491 12552-12561 Positive_regulation denotes increased
T6492 12562-12571 Positive_regulation denotes following
T6493 12635-12644 Negative_regulation denotes decreased
T6494 12649-12656 Positive_regulation denotes induced
T6495 12663-12666 Protein denotes p65
T6496 12675-12690 Phosphorylation denotes phosphorylation
T7080 14015-14024 Positive_regulation denotes increased
T7081 14025-14029 Protein denotes CREB
T7082 14034-14041 Binding denotes binding
T7586 14078-14084 Regulation denotes Effect true
T7587 14095-14100 Protein denotes TNF-α
T7588 14101-14111 Gene_expression denotes production
T7589 14112-14130 Regulation denotes in the presence of
T7590 14150-14154 Regulation denotes role
T7591 14169-14176 Positive_regulation denotes induced
T7592 14177-14191 Negative_regulation denotes downregulation
T7593 14195-14200 Protein denotes TNF-α
T7594 14201-14211 Gene_expression denotes production
T7595 14390-14398 Positive_regulation denotes resulted
T7596 14404-14413 Negative_regulation denotes reduction
T7597 14417-14422 Protein denotes TNF-α
T7598 14595-14601 Regulation denotes result true
T7599 14621-14631 Regulation denotes modulation
T7600 14635-14640 Protein denotes TNF-α
T7601 14641-14651 Gene_expression denotes production
T7602 14750-14764 Negative_regulation denotes downregulation
T7603 14768-14773 Protein denotes TNF-α
T7604 14774-14784 Gene_expression denotes production
T7605 14854-14865 Regulation denotes independent true
T8276 15099-15104 Protein denotes TNF-α
T8277 15108-15116 Localization denotes released
T8278 15128-15137 Positive_regulation denotes following
T8279 15329-15338 Positive_regulation denotes increased
T8280 15339-15344 Protein denotes TNF-α
T8281 15345-15354 Gene_expression denotes synthesis
T8282 15574-15584 Negative_regulation denotes decreasing
T8283 15585-15590 Protein denotes TNF-α
T8284 15601-15612 Negative_regulation denotes attenuating
T8285 15617-15627 Gene_expression denotes production
T8286 15679-15691 Negative_regulation denotes downregulate
T8287 15692-15697 Protein denotes TNF-α
T8288 15698-15708 Gene_expression denotes production
T8289 15788-15793 Protein denotes TNF-α
T8290 15813-15821 Positive_regulation denotes increase
T8291 15916-15924 Negative_regulation denotes decrease
T8292 15925-15930 Protein denotes TNF-α
T8293 15994-16005 Negative_regulation denotes attenuation
T8294 16013-16020 Positive_regulation denotes induced
T8295 16021-16026 Protein denotes TNF-α
T8296 16027-16037 Gene_expression denotes expression
T8297 16202-16211 Negative_regulation denotes decreases true
T8298 16212-16217 Protein denotes TNF-α
T8299 16218-16228 Gene_expression denotes production
T8300 16675-16686 Negative_regulation denotes attenuation
T8301 16690-16695 Protein denotes TNF-α
T8302 16696-16706 Gene_expression denotes production
T8303 16749-16758 Positive_regulation denotes following
T8304 16779-16790 Regulation denotes independent true
T8305 17206-17213 Regulation denotes effects
T8306 17217-17222 Protein denotes TNF-α
T8307 17223-17232 Gene_expression denotes synthesis
T8308 17310-17324 Negative_regulation denotes downregulation
T8309 17328-17333 Protein denotes TNF-α
T8310 17939-17942 Protein denotes p50
T8311 17943-17946 Protein denotes p65
T8312 18055-18060 Protein denotes I-κBα
T8313 18223-18228 Protein denotes IKK-1
T8314 18233-18238 Protein denotes IKK-2
T8315 18254-18268 Phosphorylation denotes phosphorylates
T8316 18273-18278 Protein denotes I-κBα
T8317 18288-18303 Phosphorylation denotes Phosphorylation
T8318 18305-18319 Ubiquitination denotes ubiquitination
T8319 18336-18347 Protein_catabolism denotes degradation
T8320 18351-18356 Protein denotes I-κBα
T8321 18617-18622 Protein denotes TNF-α
T8322 18689-18697 Regulation denotes involved true
T8323 18701-18706 Protein denotes TNF-α
T8324 18707-18722 Gene_expression denotes gene expression
T8325 18804-18817 Negative_regulation denotes downregulates
T8326 18804-18817 Negative_regulation denotes downregulates
T8327 18804-18817 Negative_regulation denotes downregulates
T8328 18830-18835 Protein denotes I-κBα
T8329 18836-18851 Phosphorylation denotes phosphorylation
T8330 18867-18870 Protein denotes p65
T8331 18871-18886 Phosphorylation denotes phosphorylation
T8332 18887-18900 Localization denotes translocation
T8333 19025-19030 Protein denotes I-κBα
T8334 19031-19046 Phosphorylation denotes phosphorylation
T8335 19089-19096 Regulation denotes effects
T8336 19124-19129 Protein denotes I-κBα
T8337 19242-19249 Regulation denotes effects
T8338 19260-19265 Protein denotes I-κBα
T8339 19379-19389 Regulation denotes stabilizes
T8340 19394-19405 Binding denotes interaction
T8341 19414-19419 Protein denotes I-κBα
T8342 19524-19529 Protein denotes I-κBα
T8343 19530-19541 Protein_catabolism denotes degradation
T8344 19573-19581 Regulation denotes presence
T8345 19586-19593 Regulation denotes absence true
T8346 19805-19808 Protein denotes p65
T8347 20329-20340 Negative_regulation denotes attenuation
T8348 20348-20355 Positive_regulation denotes induced
T8349 20356-20361 Protein denotes TNF-α
T8350 20362-20372 Gene_expression denotes production
T8351 20387-20406 Regulation denotes presence or absence true
T8352 21404-21407 Protein denotes CBP
T8353 21426-21430 Protein denotes p300
T8354 21679-21684 Protein denotes c-fos
T8355 21690-21695 Protein denotes c-jun
T8356 21737-21747 Positive_regulation denotes Activation
T8357 21737-21747 Positive_regulation denotes Activation
T8358 21776-21781 Protein denotes c-fos
T8359 21786-21791 Protein denotes c-jun
T8360 21851-21861 Regulation denotes implicated
T8361 21865-21870 Protein denotes TNF-α
T8362 21871-21881 Gene_expression denotes expression
T8363 21907-21916 Binding denotes recognize
T8364 21927-21947 Entity denotes DNA binding sequence
T8365 21978-21983 Protein denotes TNF-α
T8366 22155-22165 Negative_regulation denotes inhibiting
T8367 22166-22171 Protein denotes TNF-α
T8368 22177-22190 Transcription denotes transcription
T8369 22553-22566 Negative_regulation denotes downregulates
T8370 22567-22572 Protein denotes TNF-α
T8371 22573-22583 Gene_expression denotes production
T8372 22617-22628 Regulation denotes independent true
T8373 22919-22924 Protein denotes TNF-α
T8374 22925-22935 Gene_expression denotes production
R1883 T2443 T2441 themeOf serine 133,phosphorylated
R1884 T2443 T2442 partOf serine 133,CREB
R1885 T2447 T2445 themeOf serines 32,phosphorylated
R1886 T2447 T2446 partOf serines 32,I-κBα
R1887 T2448 T2444 themeOf 36,phosphorylated
R1888 T2448 T2446 partOf 36,I-κBα
R1889 T2451 T2449 themeOf serine 276,phosphorylated
R1890 T2451 T2450 partOf serine 276,p65
R2595 T3249 T3250 themeOf TNF-α,production
R2596 T3250 T3248 themeOf production,induced
R2597 T3253 T3254 themeOf TNF-α,production
R2598 T3254 T3251 themeOf production,up-regulation
R2599 T3254 T3252 themeOf production,down-regulation
R3248 T3965 T3966 themeOf TNF-α,production
R3249 T3966 T3964 themeOf production,induced
R3371 T4135 T4134 themeOf I-κBα,phosphorylated
R3372 T4137 T4136 themeOf p65,phosphorylated
R4667 T5623 T5622 themeOf induced,Role
R4668 T5624 T5625 themeOf TNF-α,production
R4669 T5625 T5623 themeOf production,induced
R4670 T5627 T5628 themeOf TNF-α,production
R4671 T5628 T5626 themeOf production,role
R4672 T5630 T5629 themeOf attenuation,involvement
R4673 T5631 T5630 themeOf induced,attenuation
R4674 T5632 T5633 themeOf TNF-α,production
R4675 T5633 T5631 themeOf production,induced
R5179 T6230 T6229 themeOf induced,effects
R5180 T6231 T6232 themeOf TNF-α,production
R5181 T6232 T6230 themeOf production,induced
R5182 T6233 T6234 themeOf TNF-α,production
R5183 T6234 T6235 themeOf production,stimulation
R5184 T6237 T6238 themeOf TNF-α,production
R5185 T6238 T6236 themeOf production,effect
R5365 T6477 T6476 themeOf degradation,leads
R5366 T6478 T6477 themeOf I-κBα,degradation
R5367 T6480 T6479 themeOf I-κBα,effects
R5368 T6481 T6482 themeOf I-κBα,phosphorylation
R5369 T6482 T6483 themeOf phosphorylation,increased
R5370 T6483 T6484 themeOf increased,following
R5371 T6486 T6485 themeOf induced,downregulated
R5372 T6487 T6488 themeOf I-κBα,phosphorylation
R5373 T6488 T6486 themeOf phosphorylation,induced
R5374 T6489 T6490 themeOf p65,phosphorylation
R5375 T6490 T6491 themeOf phosphorylation,increased
R5376 T6491 T6492 themeOf increased,following
R5377 T6494 T6493 themeOf induced,decreased
R5378 T6495 T6496 themeOf p65,phosphorylation
R5379 T6496 T6494 themeOf phosphorylation,induced
R5874 T7081 T7082 themeOf CREB,binding
R5875 T7082 T7080 themeOf binding,increased
R6258 T7586 T7589 themeOf Effect,in the presence of
R6259 T7587 T7588 themeOf TNF-α,production
R6260 T7588 T7586 themeOf production,Effect
R6261 T7591 T7590 themeOf induced,role
R6262 T7592 T7591 themeOf downregulation,induced
R6263 T7593 T7594 themeOf TNF-α,production
R6264 T7594 T7592 themeOf production,downregulation
R6265 T7596 T7595 themeOf reduction,resulted
R6266 T7597 T7596 themeOf TNF-α,reduction
R6267 T7599 T7598 themeOf modulation,result
R6268 T7600 T7601 themeOf TNF-α,production
R6269 T7601 T7599 themeOf production,modulation
R6270 T7602 T7605 themeOf downregulation,independent
R6271 T7603 T7604 themeOf TNF-α,production
R6272 T7604 T7602 themeOf production,downregulation
R6773 T8276 T8277 themeOf TNF-α,released
R6774 T8277 T8278 themeOf released,following
R6775 T8280 T8281 themeOf TNF-α,synthesis
R6776 T8281 T8279 themeOf synthesis,increased
R6777 T8283 T8285 themeOf TNF-α,production
R6778 T8283 T8282 themeOf TNF-α,decreasing
R6779 T8285 T8284 themeOf production,attenuating
R6780 T8287 T8288 themeOf TNF-α,production
R6781 T8288 T8286 themeOf production,downregulate
R6782 T8289 T8290 themeOf TNF-α,increase
R6783 T8292 T8291 themeOf TNF-α,decrease
R6784 T8294 T8293 themeOf induced,attenuation
R6785 T8295 T8296 themeOf TNF-α,expression
R6786 T8296 T8294 themeOf expression,induced
R6787 T8298 T8299 themeOf TNF-α,production
R6788 T8299 T8297 themeOf production,decreases
R6789 T8300 T8303 themeOf attenuation,following
R6790 T8300 T8304 themeOf attenuation,independent
R6791 T8301 T8302 themeOf TNF-α,production
R6792 T8302 T8300 themeOf production,attenuation
R6793 T8306 T8307 themeOf TNF-α,synthesis
R6794 T8307 T8305 themeOf synthesis,effects
R6795 T8309 T8308 themeOf TNF-α,downregulation
R6796 T8316 T8315 themeOf I-κBα,phosphorylates
R6797 T8320 T8317 themeOf I-κBα,Phosphorylation
R6798 T8320 T8318 themeOf I-κBα,ubiquitination
R6799 T8320 T8319 themeOf I-κBα,degradation
R6800 T8323 T8324 themeOf TNF-α,gene expression
R6801 T8324 T8322 themeOf gene expression,involved
R6802 T8328 T8329 themeOf I-κBα,phosphorylation
R6803 T8329 T8326 themeOf phosphorylation,downregulates
R6804 T8330 T8331 themeOf p65,phosphorylation
R6805 T8330 T8332 themeOf p65,translocation
R6806 T8331 T8325 themeOf phosphorylation,downregulates
R6807 T8332 T8327 themeOf translocation,downregulates
R6808 T8333 T8334 themeOf I-κBα,phosphorylation
R6809 T8336 T8335 themeOf I-κBα,effects
R6810 T8338 T8337 themeOf I-κBα,effects
R6811 T8340 T8339 themeOf interaction,stabilizes
R6812 T8341 T8340 themeOf I-κBα,interaction
R6813 T8342 T8343 themeOf I-κBα,degradation
R6814 T8343 T8344 themeOf degradation,presence
R6815 T8343 T8345 themeOf degradation,absence
R6816 T8347 T8351 themeOf attenuation,presence or absence
R6817 T8348 T8347 themeOf induced,attenuation
R6818 T8349 T8350 themeOf TNF-α,production
R6819 T8350 T8348 themeOf production,induced
R6820 T8358 T8356 themeOf c-fos,Activation
R6821 T8359 T8357 themeOf c-jun,Activation
R6822 T8361 T8362 themeOf TNF-α,expression
R6823 T8362 T8360 themeOf expression,implicated
R6824 T8364 T8363 themeOf DNA binding sequence,recognize
R6825 T8364 T8365 partOf DNA binding sequence,TNF-α
R6826 T8367 T8368 themeOf TNF-α,transcription
R6827 T8368 T8366 themeOf transcription,inhibiting
R6828 T8369 T8372 themeOf downregulates,independent
R6829 T8370 T8371 themeOf TNF-α,production
R6830 T8371 T8369 themeOf production,downregulates
R6831 T8373 T8374 themeOf TNF-α,production
R832 T1127 T1129 themeOf tumor necrosis factor-α,production
R833 T1128 T1127 equivalentTo TNF-α,tumor necrosis factor-α
R834 T1129 T1126 themeOf production,regulator
R835 T1131 T1132 themeOf TNF-α,synthesis
R836 T1132 T1133 themeOf synthesis,attenuated
R837 T1135 T1134 themeOf downregulation,lead
R838 T1136 T1137 themeOf TNF-α,production
R839 T1137 T1135 themeOf production,downregulation
R840 T1139 T1138 themeOf dependent,inhibit
R841 T1140 T1139 themeOf transcription,dependent
R842 T1141 T1140 themeOf TNF-α,transcription
R843 T1143 T1144 themeOf TNF-α,production
R844 T1144 T1142 themeOf production,down-regulates
R845 T1146 T1145 themeOf induced,role
R846 T1147 T1148 themeOf TNF-α,production
R847 T1148 T1146 themeOf production,induced