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PMC:2664230 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue Negation Speculation
T54 18-28 Regulation denotes Regulation
T55 32-37 Protein denotes TNF-α
T56 38-48 Gene_expression denotes Production
T57 204-210 Regulation denotes effect true
T58 294-321 Protein denotes tumor necrosis factor-alpha
T59 323-328 Protein denotes TNF-α
T60 330-340 Gene_expression denotes production
T61 423-433 Gene_expression denotes production
T62 437-442 Protein denotes TNF-α
T63 443-452 Positive_regulation denotes following
T64 583-589 Regulation denotes alters
T65 590-595 Protein denotes TNF-α
T66 596-606 Gene_expression denotes production
T67 607-625 Positive_regulation denotes in the presence of
T68 839-853 Phosphorylation denotes phosphorylated
T69 866-871 Protein denotes I-κBα
T70 891-894 Protein denotes p65
T71 1060-1065 Protein denotes TNF-α
T72 1280-1286 Negative_regulation denotes reduce
T73 1280-1286 Negative_regulation denotes reduce
T74 1299-1304 Protein denotes I-κBα
T75 1305-1320 Phosphorylation denotes phosphorylation
T76 1330-1333 Protein denotes p65
T77 1334-1349 Phosphorylation denotes phosphorylation
T78 1524-1532 Localization denotes secreted
T79 1551-1556 Protein denotes TNF-α
T80 1564-1572 Regulation denotes presence
T81 1577-1584 Regulation denotes absence true
T1126 2558-2567 Regulation denotes regulator
T1127 2571-2594 Protein denotes tumor necrosis factor-α
T1128 2596-2601 Protein denotes TNF-α
T1129 2603-2613 Gene_expression denotes production
T1130 2616-2621 Protein denotes TNF-α
T1131 2724-2729 Protein denotes TNF-α
T1132 2730-2739 Gene_expression denotes synthesis
T1133 2747-2757 Negative_regulation denotes attenuated
T1134 2952-2956 Positive_regulation denotes lead
T1135 2964-2978 Negative_regulation denotes downregulation
T1136 2982-2987 Protein denotes TNF-α
T1137 2988-2998 Gene_expression denotes production
T1138 4026-4033 Negative_regulation denotes inhibit
T1139 4040-4049 Regulation denotes dependent
T1140 4072-4085 Transcription denotes transcription
T1141 4107-4112 Protein denotes TNF-α
T1142 4196-4210 Negative_regulation denotes down-regulates
T1143 4211-4216 Protein denotes TNF-α
T1144 4217-4227 Gene_expression denotes production
T1145 4875-4879 Regulation denotes role true
T1146 4894-4901 Positive_regulation denotes induced
T1147 4902-4907 Protein denotes TNF-α
T1148 4908-4918 Gene_expression denotes production
T2441 5667-5681 Phosphorylation denotes phosphorylated
T2442 5682-5686 Protein denotes CREB
T2443 5688-5698 Entity denotes serine 133
T2444 5701-5715 Phosphorylation denotes phosphorylated
T2445 5701-5715 Phosphorylation denotes phosphorylated
T2446 5716-5721 Protein denotes I-κBα
T2447 5723-5733 Entity denotes serines 32
T2448 5738-5740 Entity denotes 36
T2449 5743-5757 Phosphorylation denotes phosphorylated
T2450 5764-5767 Protein denotes p65
T2451 5777-5787 Entity denotes serine 276
T2452 6012-6017 Protein denotes TNF-α
T3248 8217-8224 Positive_regulation denotes induced
T3249 8225-8230 Protein denotes TNF-α
T3250 8231-8241 Gene_expression denotes production
T3251 8394-8407 Positive_regulation denotes up-regulation
T3252 8412-8427 Negative_regulation denotes down-regulation
T3253 8431-8436 Protein denotes TNF-α
T3254 8437-8447 Gene_expression denotes production
T3964 8526-8533 Positive_regulation denotes induced
T3965 8534-8539 Protein denotes TNF-α
T3966 8540-8550 Gene_expression denotes production
T3967 8593-8598 Protein denotes TNF-α
T4131 8840-8845 Protein denotes I-κBα
T4132 8853-8856 Protein denotes p65
T4133 8862-8866 Protein denotes CREB
T4134 9829-9843 Phosphorylation denotes phosphorylated
T4135 9844-9849 Protein denotes I-κBα
T4136 9918-9932 Phosphorylation denotes phosphorylated
T4137 9939-9942 Protein denotes p65
T5622 12528-12532 Regulation denotes Role
T5623 12547-12554 Positive_regulation denotes induced
T5624 12572-12577 Protein denotes TNF-α
T5625 12578-12588 Gene_expression denotes production
T5626 12605-12609 Regulation denotes role
T5627 12620-12625 Protein denotes TNF-α
T5628 12626-12636 Gene_expression denotes production
T5629 12666-12677 Regulation denotes involvement
T5630 12685-12696 Negative_regulation denotes attenuation
T5631 12704-12711 Positive_regulation denotes induced
T5632 12712-12717 Protein denotes TNF-α
T5633 12718-12728 Gene_expression denotes production
T5634 13304-13309 Protein denotes TNF-α
T6229 13859-13866 Regulation denotes effects true
T6230 13881-13888 Positive_regulation denotes induced
T6231 13889-13894 Protein denotes TNF-α
T6232 13895-13905 Gene_expression denotes production
T6233 13953-13958 Protein denotes TNF-α
T6234 13959-13969 Gene_expression denotes production
T6235 13980-13991 Positive_regulation denotes stimulation
T6236 14090-14096 Regulation denotes effect
T6237 14100-14105 Protein denotes TNF-α
T6238 14106-14116 Gene_expression denotes production
T6476 14204-14209 Positive_regulation denotes leads
T6477 14232-14243 Protein_catabolism denotes degradation
T6478 14247-14252 Protein denotes I-κBα
T6479 14322-14329 Regulation denotes effects true
T6480 14340-14345 Protein denotes I-κBα
T6481 14359-14364 Protein denotes I-κBα
T6482 14365-14380 Phosphorylation denotes phosphorylation
T6483 14394-14403 Positive_regulation denotes increased
T6484 14404-14413 Positive_regulation denotes following
T6485 14522-14535 Negative_regulation denotes downregulated
T6486 14540-14547 Positive_regulation denotes induced
T6487 14548-14553 Protein denotes I-κBα
T6488 14554-14569 Phosphorylation denotes phosphorylation
T6489 14627-14630 Protein denotes p65
T6490 14631-14646 Phosphorylation denotes phosphorylation
T6491 14651-14660 Positive_regulation denotes increased
T6492 14661-14670 Positive_regulation denotes following
T6493 14734-14743 Negative_regulation denotes decreased
T6494 14748-14755 Positive_regulation denotes induced
T6495 14762-14765 Protein denotes p65
T6496 14774-14789 Phosphorylation denotes phosphorylation
T7080 16114-16123 Positive_regulation denotes increased
T7081 16124-16128 Protein denotes CREB
T7082 16133-16140 Binding denotes binding
T7586 16177-16183 Regulation denotes Effect true
T7587 16194-16199 Protein denotes TNF-α
T7588 16200-16210 Gene_expression denotes production
T7589 16211-16229 Regulation denotes in the presence of
T7590 16249-16253 Regulation denotes role
T7591 16268-16275 Positive_regulation denotes induced
T7592 16276-16290 Negative_regulation denotes downregulation
T7593 16294-16299 Protein denotes TNF-α
T7594 16300-16310 Gene_expression denotes production
T7595 16489-16497 Positive_regulation denotes resulted
T7596 16503-16512 Negative_regulation denotes reduction
T7597 16516-16521 Protein denotes TNF-α
T7598 16694-16700 Regulation denotes result true
T7599 16720-16730 Regulation denotes modulation
T7600 16734-16739 Protein denotes TNF-α
T7601 16740-16750 Gene_expression denotes production
T7602 16849-16863 Negative_regulation denotes downregulation
T7603 16867-16872 Protein denotes TNF-α
T7604 16873-16883 Gene_expression denotes production
T7605 16953-16964 Regulation denotes independent true
T8276 17198-17203 Protein denotes TNF-α
T8277 17207-17215 Localization denotes released
T8278 17227-17236 Positive_regulation denotes following
T8279 17428-17437 Positive_regulation denotes increased
T8280 17438-17443 Protein denotes TNF-α
T8281 17444-17453 Gene_expression denotes synthesis
T8282 17673-17683 Negative_regulation denotes decreasing
T8283 17684-17689 Protein denotes TNF-α
T8284 17700-17711 Negative_regulation denotes attenuating
T8285 17716-17726 Gene_expression denotes production
T8286 17778-17790 Negative_regulation denotes downregulate
T8287 17791-17796 Protein denotes TNF-α
T8288 17797-17807 Gene_expression denotes production
T8289 17887-17892 Protein denotes TNF-α
T8290 17912-17920 Positive_regulation denotes increase
T8291 18015-18023 Negative_regulation denotes decrease
T8292 18024-18029 Protein denotes TNF-α
T8293 18093-18104 Negative_regulation denotes attenuation
T8294 18112-18119 Positive_regulation denotes induced
T8295 18120-18125 Protein denotes TNF-α
T8296 18126-18136 Gene_expression denotes expression
T8297 18301-18310 Negative_regulation denotes decreases true
T8298 18311-18316 Protein denotes TNF-α
T8299 18317-18327 Gene_expression denotes production
T8300 18774-18785 Negative_regulation denotes attenuation
T8301 18789-18794 Protein denotes TNF-α
T8302 18795-18805 Gene_expression denotes production
T8303 18848-18857 Positive_regulation denotes following
T8304 18878-18889 Regulation denotes independent true
T8305 19305-19312 Regulation denotes effects
T8306 19316-19321 Protein denotes TNF-α
T8307 19322-19331 Gene_expression denotes synthesis
T8308 19409-19423 Negative_regulation denotes downregulation
T8309 19427-19432 Protein denotes TNF-α
T8310 20038-20041 Protein denotes p50
T8311 20042-20045 Protein denotes p65
T8312 20154-20159 Protein denotes I-κBα
T8313 20322-20327 Protein denotes IKK-1
T8314 20332-20337 Protein denotes IKK-2
T8315 20353-20367 Phosphorylation denotes phosphorylates
T8316 20372-20377 Protein denotes I-κBα
T8317 20387-20402 Phosphorylation denotes Phosphorylation
T8318 20404-20418 Ubiquitination denotes ubiquitination
T8319 20435-20446 Protein_catabolism denotes degradation
T8320 20450-20455 Protein denotes I-κBα
T8321 20716-20721 Protein denotes TNF-α
T8322 20788-20796 Regulation denotes involved true
T8323 20800-20805 Protein denotes TNF-α
T8324 20806-20821 Gene_expression denotes gene expression
T8325 20903-20916 Negative_regulation denotes downregulates
T8326 20903-20916 Negative_regulation denotes downregulates
T8327 20903-20916 Negative_regulation denotes downregulates
T8328 20929-20934 Protein denotes I-κBα
T8329 20935-20950 Phosphorylation denotes phosphorylation
T8330 20966-20969 Protein denotes p65
T8331 20970-20985 Phosphorylation denotes phosphorylation
T8332 20986-20999 Localization denotes translocation
T8333 21124-21129 Protein denotes I-κBα
T8334 21130-21145 Phosphorylation denotes phosphorylation
T8335 21188-21195 Regulation denotes effects
T8336 21223-21228 Protein denotes I-κBα
T8337 21341-21348 Regulation denotes effects
T8338 21359-21364 Protein denotes I-κBα
T8339 21478-21488 Regulation denotes stabilizes
T8340 21493-21504 Binding denotes interaction
T8341 21513-21518 Protein denotes I-κBα
T8342 21623-21628 Protein denotes I-κBα
T8343 21629-21640 Protein_catabolism denotes degradation
T8344 21672-21680 Regulation denotes presence
T8345 21685-21692 Regulation denotes absence true
T8346 21904-21907 Protein denotes p65
T8347 22428-22439 Negative_regulation denotes attenuation
T8348 22447-22454 Positive_regulation denotes induced
T8349 22455-22460 Protein denotes TNF-α
T8350 22461-22471 Gene_expression denotes production
T8351 22486-22505 Regulation denotes presence or absence true
T8352 23503-23506 Protein denotes CBP
T8353 23525-23529 Protein denotes p300
T8354 23778-23783 Protein denotes c-fos
T8355 23789-23794 Protein denotes c-jun
T8356 23836-23846 Positive_regulation denotes Activation
T8357 23836-23846 Positive_regulation denotes Activation
T8358 23875-23880 Protein denotes c-fos
T8359 23885-23890 Protein denotes c-jun
T8360 23950-23960 Regulation denotes implicated
T8361 23964-23969 Protein denotes TNF-α
T8362 23970-23980 Gene_expression denotes expression
T8363 24006-24015 Binding denotes recognize
T8364 24026-24046 Entity denotes DNA binding sequence
T8365 24077-24082 Protein denotes TNF-α
T8366 24254-24264 Negative_regulation denotes inhibiting
T8367 24265-24270 Protein denotes TNF-α
T8368 24276-24289 Transcription denotes transcription
T8369 24652-24665 Negative_regulation denotes downregulates
T8370 24666-24671 Protein denotes TNF-α
T8371 24672-24682 Gene_expression denotes production
T8372 24716-24727 Regulation denotes independent true
T8373 25018-25023 Protein denotes TNF-α
T8374 25024-25034 Gene_expression denotes production
R1883 T2443 T2441 themeOf serine 133,phosphorylated
R1884 T2443 T2442 partOf serine 133,CREB
R1885 T2447 T2445 themeOf serines 32,phosphorylated
R1886 T2447 T2446 partOf serines 32,I-κBα
R1887 T2448 T2444 themeOf 36,phosphorylated
R1888 T2448 T2446 partOf 36,I-κBα
R1889 T2451 T2449 themeOf serine 276,phosphorylated
R1890 T2451 T2450 partOf serine 276,p65
R2595 T3249 T3250 themeOf TNF-α,production
R2596 T3250 T3248 themeOf production,induced
R2597 T3253 T3254 themeOf TNF-α,production
R2598 T3254 T3251 themeOf production,up-regulation
R2599 T3254 T3252 themeOf production,down-regulation
R3248 T3965 T3966 themeOf TNF-α,production
R3249 T3966 T3964 themeOf production,induced
R33 T64 T67 themeOf alters,in the presence of
R3371 T4135 T4134 themeOf I-κBα,phosphorylated
R3372 T4137 T4136 themeOf p65,phosphorylated
R34 T65 T66 themeOf TNF-α,production
R35 T66 T64 themeOf production,alters
R36 T69 T68 themeOf I-κBα,phosphorylated
R37 T74 T75 themeOf I-κBα,phosphorylation
R38 T75 T73 themeOf phosphorylation,reduce
R39 T76 T77 themeOf p65,phosphorylation
R40 T77 T72 themeOf phosphorylation,reduce
R41 T78 T80 themeOf secreted,presence
R42 T78 T81 themeOf secreted,absence
R43 T79 T78 themeOf TNF-α,secreted
R4667 T5623 T5622 themeOf induced,Role
R4668 T5624 T5625 themeOf TNF-α,production
R4669 T5625 T5623 themeOf production,induced
R4670 T5627 T5628 themeOf TNF-α,production
R4671 T5628 T5626 themeOf production,role
R4672 T5630 T5629 themeOf attenuation,involvement
R4673 T5631 T5630 themeOf induced,attenuation
R4674 T5632 T5633 themeOf TNF-α,production
R4675 T5633 T5631 themeOf production,induced
R5179 T6230 T6229 themeOf induced,effects
R5180 T6231 T6232 themeOf TNF-α,production
R5181 T6232 T6230 themeOf production,induced
R5182 T6233 T6234 themeOf TNF-α,production
R5183 T6234 T6235 themeOf production,stimulation
R5184 T6237 T6238 themeOf TNF-α,production
R5185 T6238 T6236 themeOf production,effect
R5365 T6477 T6476 themeOf degradation,leads
R5366 T6478 T6477 themeOf I-κBα,degradation
R5367 T6480 T6479 themeOf I-κBα,effects
R5368 T6481 T6482 themeOf I-κBα,phosphorylation
R5369 T6482 T6483 themeOf phosphorylation,increased
R5370 T6483 T6484 themeOf increased,following
R5371 T6486 T6485 themeOf induced,downregulated
R5372 T6487 T6488 themeOf I-κBα,phosphorylation
R5373 T6488 T6486 themeOf phosphorylation,induced
R5374 T6489 T6490 themeOf p65,phosphorylation
R5375 T6490 T6491 themeOf phosphorylation,increased
R5376 T6491 T6492 themeOf increased,following
R5377 T6494 T6493 themeOf induced,decreased
R5378 T6495 T6496 themeOf p65,phosphorylation
R5379 T6496 T6494 themeOf phosphorylation,induced
R5874 T7081 T7082 themeOf CREB,binding
R5875 T7082 T7080 themeOf binding,increased
R6258 T7586 T7589 themeOf Effect,in the presence of
R6259 T7587 T7588 themeOf TNF-α,production
R6260 T7588 T7586 themeOf production,Effect
R6261 T7591 T7590 themeOf induced,role
R6262 T7592 T7591 themeOf downregulation,induced
R6263 T7593 T7594 themeOf TNF-α,production
R6264 T7594 T7592 themeOf production,downregulation
R6265 T7596 T7595 themeOf reduction,resulted
R6266 T7597 T7596 themeOf TNF-α,reduction
R6267 T7599 T7598 themeOf modulation,result
R6268 T7600 T7601 themeOf TNF-α,production
R6269 T7601 T7599 themeOf production,modulation
R6270 T7602 T7605 themeOf downregulation,independent
R6271 T7603 T7604 themeOf TNF-α,production
R6272 T7604 T7602 themeOf production,downregulation
R6773 T8276 T8277 themeOf TNF-α,released
R6774 T8277 T8278 themeOf released,following
R6775 T8280 T8281 themeOf TNF-α,synthesis
R6776 T8281 T8279 themeOf synthesis,increased
R6777 T8283 T8285 themeOf TNF-α,production
R6778 T8283 T8282 themeOf TNF-α,decreasing
R6779 T8285 T8284 themeOf production,attenuating
R6780 T8287 T8288 themeOf TNF-α,production
R6781 T8288 T8286 themeOf production,downregulate
R6782 T8289 T8290 themeOf TNF-α,increase
R6783 T8292 T8291 themeOf TNF-α,decrease
R6784 T8294 T8293 themeOf induced,attenuation
R6785 T8295 T8296 themeOf TNF-α,expression
R6786 T8296 T8294 themeOf expression,induced
R6787 T8298 T8299 themeOf TNF-α,production
R6788 T8299 T8297 themeOf production,decreases
R6789 T8300 T8303 themeOf attenuation,following
R6790 T8300 T8304 themeOf attenuation,independent
R6791 T8301 T8302 themeOf TNF-α,production
R6792 T8302 T8300 themeOf production,attenuation
R6793 T8306 T8307 themeOf TNF-α,synthesis
R6794 T8307 T8305 themeOf synthesis,effects
R6795 T8309 T8308 themeOf TNF-α,downregulation
R6796 T8316 T8315 themeOf I-κBα,phosphorylates
R6797 T8320 T8317 themeOf I-κBα,Phosphorylation
R6798 T8320 T8318 themeOf I-κBα,ubiquitination
R6799 T8320 T8319 themeOf I-κBα,degradation
R6800 T8323 T8324 themeOf TNF-α,gene expression
R6801 T8324 T8322 themeOf gene expression,involved
R6802 T8328 T8329 themeOf I-κBα,phosphorylation
R6803 T8329 T8326 themeOf phosphorylation,downregulates
R6804 T8330 T8331 themeOf p65,phosphorylation
R6805 T8330 T8332 themeOf p65,translocation
R6806 T8331 T8325 themeOf phosphorylation,downregulates
R6807 T8332 T8327 themeOf translocation,downregulates
R6808 T8333 T8334 themeOf I-κBα,phosphorylation
R6809 T8336 T8335 themeOf I-κBα,effects
R6810 T8338 T8337 themeOf I-κBα,effects
R6811 T8340 T8339 themeOf interaction,stabilizes
R6812 T8341 T8340 themeOf I-κBα,interaction
R6813 T8342 T8343 themeOf I-κBα,degradation
R6814 T8343 T8344 themeOf degradation,presence
R6815 T8343 T8345 themeOf degradation,absence
R6816 T8347 T8351 themeOf attenuation,presence or absence
R6817 T8348 T8347 themeOf induced,attenuation
R6818 T8349 T8350 themeOf TNF-α,production
R6819 T8350 T8348 themeOf production,induced
R6820 T8358 T8356 themeOf c-fos,Activation
R6821 T8359 T8357 themeOf c-jun,Activation
R6822 T8361 T8362 themeOf TNF-α,expression
R6823 T8362 T8360 themeOf expression,implicated
R6824 T8364 T8363 themeOf DNA binding sequence,recognize
R6825 T8364 T8365 partOf DNA binding sequence,TNF-α
R6826 T8367 T8368 themeOf TNF-α,transcription
R6827 T8368 T8366 themeOf transcription,inhibiting
R6828 T8369 T8372 themeOf downregulates,independent
R6829 T8370 T8371 themeOf TNF-α,production
R6830 T8371 T8369 themeOf production,downregulates
R6831 T8373 T8374 themeOf TNF-α,production
R748 T55 T56 themeOf TNF-α,Production
R749 T56 T54 themeOf Production,Regulation
R750 T58 T60 themeOf tumor necrosis factor-alpha,production
R751 T60 T57 themeOf production,effect
R752 T61 T63 themeOf production,following
R753 T62 T61 themeOf TNF-α,production
R832 T1127 T1129 themeOf tumor necrosis factor-α,production
R833 T1128 T1127 equivalentTo TNF-α,tumor necrosis factor-α
R834 T1129 T1126 themeOf production,regulator
R835 T1131 T1132 themeOf TNF-α,synthesis
R836 T1132 T1133 themeOf synthesis,attenuated
R837 T1135 T1134 themeOf downregulation,lead
R838 T1136 T1137 themeOf TNF-α,production
R839 T1137 T1135 themeOf production,downregulation
R840 T1139 T1138 themeOf dependent,inhibit
R841 T1140 T1139 themeOf transcription,dependent
R842 T1141 T1140 themeOf TNF-α,transcription
R843 T1143 T1144 themeOf TNF-α,production
R844 T1144 T1142 themeOf production,down-regulates
R845 T1146 T1145 themeOf induced,role
R846 T1147 T1148 themeOf TNF-α,production
R847 T1148 T1146 themeOf production,induced