| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T2135 |
13-20 |
Protein |
denotes |
SHARPIN |
| T2136 |
150-159 |
Gene_expression |
denotes |
expressed |
| T2137 |
239-251 |
Protein |
denotes |
Sharpin gene |
| T2141 |
1108-1117 |
Negative_regulation |
denotes |
decreased |
| T2140 |
1118-1127 |
Localization |
denotes |
secretion |
| T2138 |
1131-1139 |
Protein |
denotes |
IFNγ [5] |
| T2139 |
1164-1167 |
Protein |
denotes |
Th1 |
| T2142 |
1276-1280 |
Protein |
denotes |
IL12 |
| T2143 |
1348-1351 |
Protein |
denotes |
IL5 |
| T2144 |
1390-1393 |
Protein |
denotes |
IL5 |
| T2145 |
1394-1403 |
Negative_regulation |
denotes |
deficient |
| T2146 |
1583-1590 |
Protein |
denotes |
SHARPIN |
| T2147 |
1687-1691 |
Protein |
denotes |
TNFα |
| T2148 |
1710-1715 |
Protein |
denotes |
NF-κB |
| T2149 |
1735-1742 |
Protein |
denotes |
SHARPIN |
| T2151 |
1743-1752 |
Negative_regulation |
denotes |
deficient |
| T2150 |
1805-1809 |
Protein |
denotes |
TNFα |
| T2152 |
2246-2250 |
Protein |
denotes |
CD4+ |
| T2153 |
2457-2464 |
Protein |
denotes |
SHARPIN |
| T2154 |
2465-2474 |
Negative_regulation |
denotes |
deficient |
| T2157 |
2518-2522 |
Negative_regulation |
denotes |
lack |
| T2155 |
2526-2541 |
Protein |
denotes |
SHARPIN protein |
| T2159 |
2612-2620 |
Negative_regulation |
denotes |
impaired |
| T2156 |
2621-2626 |
Protein |
denotes |
NF-κB |
| T2158 |
2627-2637 |
Positive_regulation |
denotes |
activation |
| T2162 |
2691-2700 |
Positive_regulation |
denotes |
stimulate |
| T2160 |
2701-2704 |
Protein |
denotes |
Th1 |
| T2161 |
2714-2724 |
Gene_expression |
denotes |
production |
| T2163 |
2811-2818 |
Protein |
denotes |
SHARPIN |
| T2164 |
2910-2917 |
Protein |
denotes |
SHARPIN |
| T2165 |
2918-2927 |
Negative_regulation |
denotes |
deficient |
| T2771 |
3019-3034 |
Protein |
denotes |
SHARPIN protein |
| T2772 |
3178-3185 |
Protein |
denotes |
SHARPIN |
| T2773 |
3224-3233 |
Protein |
denotes |
ubiquitin |
| T2774 |
3259-3292 |
Protein |
denotes |
zinc-finger Ran-binding protein 2 |
| T2775 |
3294-3299 |
Protein |
denotes |
ZFRBP |
| T2776 |
3301-3307 |
Entity |
denotes |
domain |
| T2779 |
3377-3384 |
Gene_expression |
denotes |
present |
| T2777 |
3392-3407 |
Protein |
denotes |
SHARPIN protein |
| T2778 |
3456-3463 |
Protein |
denotes |
SHARPIN |
| T2780 |
3549-3561 |
Protein |
denotes |
Sharpin gene |
| T2782 |
3766-3776 |
Transcription |
denotes |
expression |
| T2781 |
3780-3787 |
Protein |
denotes |
Sharpin |
| T2783 |
3920-3932 |
Protein |
denotes |
Sharpin mRNA |
| T2784 |
4013-4022 |
Negative_regulation |
denotes |
decreased |
| T2786 |
4067-4076 |
Negative_regulation |
denotes |
reduction |
| T2785 |
4080-4092 |
Protein |
denotes |
Sharpin mRNA |
| T2790 |
4138-4150 |
Gene_expression |
denotes |
Transfection |
| T2791 |
4138-4150 |
Positive_regulation |
denotes |
Transfection |
| T2787 |
4166-4173 |
Protein |
denotes |
Sharpin |
| T2792 |
4235-4246 |
Entity |
denotes |
cytoplasmic |
| T2793 |
4247-4259 |
Localization |
denotes |
localization |
| T2794 |
4247-4259 |
Localization |
denotes |
localization |
| T2788 |
4267-4282 |
Protein |
denotes |
SHARPIN protein |
| T2789 |
4284-4291 |
Protein |
denotes |
Fig. 1E |
| T13246 |
4371-4378 |
Protein |
denotes |
SHARPIN |
| T13247 |
4475-4478 |
Protein |
denotes |
UBL |
| T13248 |
4480-4489 |
Protein |
denotes |
ubiquitin |
| T13249 |
4507-4512 |
Protein |
denotes |
ZFRBP |
| T13250 |
4514-4547 |
Protein |
denotes |
zinc-finger Ran-Binding protein 2 |
| T13251 |
4597-4612 |
Protein |
denotes |
SHARPIN protein |
| T13252 |
4972-4979 |
Protein |
denotes |
Sharpin |
| T13254 |
5039-5049 |
Transcription |
denotes |
expression |
| T13253 |
5068-5075 |
Protein |
denotes |
WT BMDC |
| T13255 |
5420-5424 |
Protein |
denotes |
FLAG |
| T13256 |
5425-5432 |
Protein |
denotes |
SHARPIN |
| T4275 |
8668-8676 |
Positive_regulation |
denotes |
resulted |
| T4276 |
8668-8676 |
Positive_regulation |
denotes |
resulted |
| T4277 |
8668-8676 |
Positive_regulation |
denotes |
resulted |
| T4270 |
8680-8689 |
Localization |
denotes |
secretion |
| T4271 |
8680-8689 |
Localization |
denotes |
secretion |
| T4272 |
8680-8689 |
Localization |
denotes |
secretion |
| T4265 |
8693-8696 |
Protein |
denotes |
IL6 |
| T4266 |
8698-8705 |
Protein |
denotes |
IL12P70 |
| T4267 |
8711-8716 |
Protein |
denotes |
GMCSF |
| T4273 |
8774-8782 |
Gene_expression |
denotes |
produced |
| T4274 |
8774-8782 |
Gene_expression |
denotes |
produced |
| T4268 |
8839-8846 |
Protein |
denotes |
WT BMDC |
| T4269 |
8848-8851 |
Protein |
denotes |
Fig |
| T4278 |
9057-9064 |
Protein |
denotes |
Sharpin |
| T4279 |
9065-9074 |
Negative_regulation |
denotes |
deficient |
| T4280 |
9112-9119 |
Protein |
denotes |
Sharpin |
| T4284 |
9230-9238 |
Localization |
denotes |
secreted |
| T4281 |
9258-9265 |
Protein |
denotes |
IL12P70 |
| T4286 |
9325-9329 |
Positive_regulation |
denotes |
role |
| T4282 |
9333-9340 |
Protein |
denotes |
SHARPIN |
| T4285 |
9349-9359 |
Gene_expression |
denotes |
production |
| T4283 |
9363-9370 |
Protein |
denotes |
IL12P70 |
| T4289 |
9400-9406 |
Transcription |
denotes |
levels |
| T4290 |
9400-9406 |
Transcription |
denotes |
levels |
| T4287 |
9427-9440 |
Protein |
denotes |
cytokines Il6 |
| T4288 |
9442-9449 |
Protein |
denotes |
Il12p40 |
| T4291 |
9515-9522 |
Negative_regulation |
denotes |
reduced |
| T4292 |
9515-9522 |
Negative_regulation |
denotes |
reduced |
| T14226 |
9912-9919 |
Protein |
denotes |
IL12P70 |
| T14227 |
9921-9924 |
Protein |
denotes |
IL6 |
| T14228 |
9930-9935 |
Protein |
denotes |
GMCSF |
| T14229 |
10142-10149 |
Protein |
denotes |
IL12P70 |
| T14230 |
10154-10157 |
Protein |
denotes |
IL6 |
| T14231 |
10223-10245 |
Protein |
denotes |
Sharpin-containing BAC |
| T14232 |
10482-10489 |
Protein |
denotes |
IL12P70 |
| T14233 |
10490-10500 |
Gene_expression |
denotes |
production |
| T14538 |
10904-10907 |
Protein |
denotes |
qRT |
| T5633 |
11166-11171 |
Protein |
denotes |
NF-κB |
| T5636 |
11416-11425 |
Positive_regulation |
denotes |
increased |
| T5635 |
11426-11436 |
Gene_expression |
denotes |
expression |
| T5634 |
11463-11466 |
Protein |
denotes |
TLR |
| T5643 |
11553-11563 |
Gene_expression |
denotes |
expression |
| T5644 |
11553-11563 |
Gene_expression |
denotes |
expression |
| T5637 |
11571-11583 |
Protein |
denotes |
LPS receptor |
| T5638 |
11607-11611 |
Protein |
denotes |
TLR4 |
| T5639 |
11636-11640 |
Protein |
denotes |
CD14 |
| T5640 |
11645-11677 |
Protein |
denotes |
myeloid differentiation factor 2 |
| T5641 |
11679-11682 |
Protein |
denotes |
MD2 |
| T5642 |
11683-11687 |
Protein |
denotes |
LY96 |
| T5648 |
11735-11745 |
Gene_expression |
denotes |
expression |
| T5649 |
11735-11745 |
Gene_expression |
denotes |
expression |
| T5650 |
11735-11745 |
Gene_expression |
denotes |
expression |
| T5645 |
11756-11760 |
Protein |
denotes |
CD14 |
| T5646 |
11765-11769 |
Protein |
denotes |
TLR4 |
| T5647 |
11770-11773 |
Protein |
denotes |
MD2 |
| T5653 |
11846-11855 |
Localization |
denotes |
secretion |
| T5651 |
11875-11889 |
Protein |
denotes |
cytokines IL10 |
| T5655 |
11899-11906 |
Negative_regulation |
denotes |
inhibit |
| T5652 |
11907-11911 |
Protein |
denotes |
IL12 |
| T5654 |
11912-11921 |
Localization |
denotes |
secretion |
| T5656 |
12044-12048 |
Protein |
denotes |
IL10 |
| T5659 |
12054-12064 |
Positive_regulation |
denotes |
stimulated |
| T5657 |
12100-12104 |
Protein |
denotes |
IL10 |
| T5661 |
12113-12124 |
Positive_regulation |
denotes |
responsible |
| T5662 |
12129-12138 |
Negative_regulation |
denotes |
decreased |
| T5660 |
12139-12148 |
Localization |
denotes |
secretion |
| T5658 |
12152-12159 |
Protein |
denotes |
IL12P70 |
| T5665 |
12174-12183 |
Positive_regulation |
denotes |
Increased |
| T5664 |
12184-12194 |
Gene_expression |
denotes |
expression |
| T5663 |
12222-12225 |
Protein |
denotes |
TLR |
| T5666 |
12324-12327 |
Protein |
denotes |
A20 |
| T5670 |
12401-12407 |
Positive_regulation |
denotes |
ruling |
| T5671 |
12401-12407 |
Positive_regulation |
denotes |
ruling |
| T5668 |
12412-12426 |
Gene_expression |
denotes |
overexpression |
| T5669 |
12412-12426 |
Positive_regulation |
denotes |
overexpression |
| T5667 |
12430-12433 |
Protein |
denotes |
A20 |
| T14953 |
12533-12537 |
Protein |
denotes |
TLR4 |
| T14954 |
12542-12545 |
Protein |
denotes |
MD2 |
| T14956 |
12546-12556 |
Gene_expression |
denotes |
expression |
| T14957 |
12546-12556 |
Gene_expression |
denotes |
expression |
| T14958 |
12561-12570 |
Negative_regulation |
denotes |
decreased |
| T14959 |
12561-12570 |
Negative_regulation |
denotes |
decreased |
| T14961 |
12561-12570 |
Negative_regulation |
denotes |
decreased |
| T14955 |
12571-12575 |
Protein |
denotes |
IL10 |
| T14960 |
12576-12585 |
Localization |
denotes |
secretion |
| T14962 |
12695-12699 |
Protein |
denotes |
TLR4 |
| T14963 |
12700-12703 |
Protein |
denotes |
MD2 |
| T14964 |
12712-12716 |
Protein |
denotes |
CD14 |
| T14965 |
13006-13010 |
Protein |
denotes |
IL10 |
| T14966 |
13211-13214 |
Protein |
denotes |
qRT |
| T14968 |
13234-13244 |
Gene_expression |
denotes |
production |
| T14967 |
13248-13251 |
Protein |
denotes |
A20 |
| T5672 |
13277-13281 |
Protein |
denotes |
TLR3 |
| T5676 |
13333-13342 |
Regulation |
denotes |
regulated |
| T5677 |
13333-13342 |
Regulation |
denotes |
regulated |
| T5678 |
13333-13342 |
Regulation |
denotes |
regulated |
| T5673 |
13389-13394 |
Protein |
denotes |
NF-κB |
| T5674 |
13396-13400 |
Protein |
denotes |
TBK1 |
| T5675 |
13401-13405 |
Protein |
denotes |
IRF3 |
| T5679 |
13459-13464 |
Protein |
denotes |
NF-κB |
| T5680 |
13466-13470 |
Protein |
denotes |
TBK1 |
| T5681 |
13471-13475 |
Protein |
denotes |
IRF3 |
| T5682 |
13484-13488 |
Protein |
denotes |
MAPK |
| T5683 |
13561-13568 |
Protein |
denotes |
Sharpin |
| T5684 |
13569-13578 |
Negative_regulation |
denotes |
deficient |
| T5699 |
13585-13601 |
Positive_regulation |
denotes |
Stimulus-induced |
| T5700 |
13585-13601 |
Positive_regulation |
denotes |
Stimulus-induced |
| T5691 |
13602-13617 |
Phosphorylation |
denotes |
phosphorylation |
| T5692 |
13602-13617 |
Phosphorylation |
denotes |
phosphorylation |
| T5685 |
13625-13635 |
Protein |
denotes |
IκB kinase |
| T5686 |
13637-13643 |
Protein |
denotes |
IKK1/2 |
| T5687 |
13669-13674 |
Protein |
denotes |
NF-κB |
| T5701 |
13686-13694 |
Positive_regulation |
denotes |
allowing |
| T5702 |
13686-13694 |
Positive_regulation |
denotes |
allowing |
| T5703 |
13686-13694 |
Positive_regulation |
denotes |
allowing |
| T5693 |
13695-13710 |
Phosphorylation |
denotes |
phosphorylation |
| T5694 |
13695-13710 |
Phosphorylation |
denotes |
phosphorylation |
| T5704 |
13715-13734 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5705 |
13715-13734 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5706 |
13715-13734 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5695 |
13735-13746 |
Protein_catabolism |
denotes |
degradation |
| T5696 |
13735-13746 |
Protein_catabolism |
denotes |
degradation |
| T5697 |
13735-13746 |
Protein_catabolism |
denotes |
degradation |
| T5688 |
13754-13759 |
Protein |
denotes |
NF-κB |
| T5689 |
13770-13774 |
Protein |
denotes |
IκBα |
| T5707 |
13778-13785 |
Localization |
denotes |
release |
| T5690 |
13790-13817 |
Protein |
denotes |
NF-κB transcription factors |
| T5698 |
13827-13834 |
Entity |
denotes |
nucleus |
| T5716 |
14032-14041 |
Negative_regulation |
denotes |
exhibited |
| T5717 |
14032-14041 |
Negative_regulation |
denotes |
exhibited |
| T5711 |
14050-14056 |
Positive_regulation |
denotes |
levels |
| T5712 |
14050-14056 |
Positive_regulation |
denotes |
levels |
| T5718 |
14050-14056 |
Positive_regulation |
denotes |
levels |
| T5719 |
14050-14056 |
Positive_regulation |
denotes |
levels |
| T5720 |
14050-14056 |
Positive_regulation |
denotes |
levels |
| T5708 |
14060-14064 |
Protein |
denotes |
TBK1 |
| T5709 |
14066-14072 |
Protein |
denotes |
ERK1/2 |
| T5710 |
14078-14081 |
Protein |
denotes |
p38 |
| T5713 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
| T5714 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
| T5715 |
14082-14097 |
Phosphorylation |
denotes |
phosphorylation |
| T5727 |
14161-14168 |
Negative_regulation |
denotes |
absence |
| T5721 |
14183-14203 |
Protein |
denotes |
SHARPIN decreased NF |
| T5722 |
14204-14206 |
Protein |
denotes |
κB |
| T5728 |
14207-14217 |
Positive_regulation |
denotes |
activation |
| T5729 |
14230-14236 |
Regulation |
denotes |
affect |
| T5730 |
14230-14236 |
Regulation |
denotes |
affect |
| T5731 |
14230-14236 |
Regulation |
denotes |
affect |
| T5723 |
14237-14241 |
Protein |
denotes |
TBK1 |
| T5724 |
14242-14246 |
Protein |
denotes |
IRF3 |
| T5725 |
14248-14252 |
Protein |
denotes |
ERK1 |
| T5726 |
14260-14263 |
Protein |
denotes |
p38 |
| T15304 |
14327-14337 |
Negative_regulation |
denotes |
Inhibition |
| T15303 |
14341-14346 |
Protein |
denotes |
NF-κB |
| T15305 |
14628-14633 |
Protein |
denotes |
NF-κB |
| T15306 |
14635-14639 |
Protein |
denotes |
TBK1 |
| T15307 |
14640-14644 |
Protein |
denotes |
IRF3 |
| T15308 |
14646-14650 |
Protein |
denotes |
ERK1 |
| T15309 |
14658-14661 |
Protein |
denotes |
p38 |
| T15310 |
14682-14686 |
Protein |
denotes |
Beta |
| T15311 |
14687-14692 |
Protein |
denotes |
actin |
| T15315 |
14735-14741 |
Gene_expression |
denotes |
levels |
| T15312 |
14758-14764 |
Protein |
denotes |
p-IκBα |
| T15313 |
14823-14829 |
Protein |
denotes |
ImageJ |
| T15314 |
14831-14834 |
Protein |
denotes |
NIH |
| T6556 |
14989-14998 |
Negative_regulation |
denotes |
defective |
| T6553 |
14999-15003 |
Protein |
denotes |
IL12 |
| T6555 |
15004-15014 |
Gene_expression |
denotes |
production |
| T6554 |
15104-15111 |
Protein |
denotes |
SHARPIN |
| T6557 |
15230-15234 |
Protein |
denotes |
CD4+ |
| T6558 |
15248-15255 |
Protein |
denotes |
WT BMDC |
| T6559 |
15350-15354 |
Protein |
denotes |
IFNγ |
| T6560 |
15461-15464 |
Protein |
denotes |
Th1 |
| T6561 |
15536-15555 |
Protein |
denotes |
TLR2 ligand Pam3CYS |
| T6564 |
15592-15598 |
Positive_regulation |
denotes |
induce |
| T6565 |
15592-15598 |
Positive_regulation |
denotes |
induce |
| T6562 |
15604-15607 |
Protein |
denotes |
Th1 |
| T6563 |
15612-15615 |
Protein |
denotes |
Th2 |
| T6566 |
15653-15660 |
Protein |
denotes |
WT BMDC |
| T6569 |
15661-15668 |
Positive_regulation |
denotes |
induced |
| T6567 |
15669-15680 |
Protein |
denotes |
robust IFNγ |
| T6568 |
15681-15691 |
Gene_expression |
denotes |
production |
| T6573 |
15754-15761 |
Negative_regulation |
denotes |
reduced |
| T6570 |
15762-15765 |
Protein |
denotes |
Th1 |
| T6575 |
15842-15848 |
Negative_regulation |
denotes |
report |
| T6576 |
15852-15861 |
Negative_regulation |
denotes |
decreased |
| T6571 |
15862-15866 |
Protein |
denotes |
IL12 |
| T6574 |
15867-15877 |
Gene_expression |
denotes |
production |
| T6572 |
15908-15912 |
Protein |
denotes |
TLR2 |
| T6577 |
15962-15965 |
Protein |
denotes |
IL4 |
| T6579 |
16103-16113 |
Gene_expression |
denotes |
production |
| T6578 |
16117-16145 |
Protein |
denotes |
Th17-specific cytokine IL17A |
| T6580 |
16289-16292 |
Protein |
denotes |
Th1 |
| T6586 |
16363-16372 |
Positive_regulation |
denotes |
effective |
| T6581 |
16376-16379 |
Protein |
denotes |
IL2 |
| T6584 |
16380-16390 |
Gene_expression |
denotes |
production |
| T6582 |
16458-16465 |
Protein |
denotes |
WT BMDC |
| T6585 |
16466-16473 |
Positive_regulation |
denotes |
induced |
| T6583 |
16479-16482 |
Protein |
denotes |
IL2 |
| T6587 |
16599-16603 |
Protein |
denotes |
CD4+ |
| T15733 |
16805-16809 |
Protein |
denotes |
CD4+ |
| T15734 |
16876-16895 |
Protein |
denotes |
MHC haplotype: H-2b |
| T15735 |
17074-17078 |
Protein |
denotes |
CD4+ |
| T15736 |
17129-17142 |
Protein |
denotes |
MHC haplotype |
| T15740 |
17201-17210 |
Localization |
denotes |
secretion |
| T15741 |
17201-17210 |
Localization |
denotes |
secretion |
| T15742 |
17201-17210 |
Localization |
denotes |
secretion |
| T15737 |
17214-17218 |
Protein |
denotes |
IFNγ |
| T15738 |
17220-17223 |
Protein |
denotes |
IL4 |
| T15739 |
17229-17232 |
Protein |
denotes |
IL2 |
| T9454 |
17650-17668 |
Protein |
denotes |
mouse Sharpin gene |
| T9455 |
17677-17683 |
Regulation |
denotes |
affect |
| T9456 |
18056-18061 |
Protein |
denotes |
NF-κB |
| T9457 |
18167-18170 |
Protein |
denotes |
Th2 |
| T9458 |
18271-18278 |
Protein |
denotes |
SHARPIN |
| T9459 |
18992-18996 |
Protein |
denotes |
TNFα |
| T9460 |
19079-19082 |
Protein |
denotes |
TNF |
| T9462 |
19109-19119 |
Negative_regulation |
denotes |
deficiency |
| T9461 |
19123-19130 |
Protein |
denotes |
SHARPIN |
| T9463 |
19352-19359 |
Protein |
denotes |
caspase |
| T9466 |
19450-19457 |
Localization |
denotes |
release |
| T9464 |
19475-19480 |
Protein |
denotes |
DAMPs |
| T9465 |
19601-19606 |
Protein |
denotes |
HMGB1 |
| T9467 |
19607-19617 |
Binding |
denotes |
recognized |
| T9468 |
19669-19672 |
Protein |
denotes |
Th1 |
| T9469 |
19740-19743 |
Protein |
denotes |
Th1 |
| T9470 |
19860-19864 |
Protein |
denotes |
IL12 |
| T9473 |
19993-20000 |
Negative_regulation |
denotes |
reduced |
| T9471 |
20001-20008 |
Protein |
denotes |
IL12P70 |
| T9472 |
20009-20019 |
Gene_expression |
denotes |
production |
| T9476 |
20033-20043 |
Positive_regulation |
denotes |
importance |
| T9474 |
20047-20054 |
Protein |
denotes |
IL12P70 |
| T9475 |
20134-20154 |
Protein |
denotes |
IL12P35- and IL12P40 |
| T9477 |
20239-20244 |
Protein |
denotes |
NF-κB |
| T9478 |
20246-20249 |
Protein |
denotes |
TBK |
| T9479 |
20250-20254 |
Protein |
denotes |
IRF3 |
| T9480 |
20260-20264 |
Protein |
denotes |
MAPK |
| T9481 |
20403-20408 |
Protein |
denotes |
NF-κB |
| T9487 |
20409-20419 |
Positive_regulation |
denotes |
activation |
| T9488 |
20436-20445 |
Negative_regulation |
denotes |
inhibited |
| T9489 |
20516-20526 |
Positive_regulation |
denotes |
activation |
| T9490 |
20516-20526 |
Positive_regulation |
denotes |
activation |
| T9491 |
20516-20526 |
Positive_regulation |
denotes |
activation |
| T9492 |
20516-20526 |
Positive_regulation |
denotes |
activation |
| T9482 |
20530-20534 |
Protein |
denotes |
TBK1 |
| T9483 |
20535-20539 |
Protein |
denotes |
IRF3 |
| T9484 |
20541-20545 |
Protein |
denotes |
ERK1 |
| T9485 |
20552-20555 |
Protein |
denotes |
p38 |
| T9486 |
20591-20596 |
Protein |
denotes |
NF-κB |
| T9497 |
20731-20740 |
Positive_regulation |
denotes |
increased |
| T9498 |
20731-20740 |
Positive_regulation |
denotes |
increased |
| T9493 |
20751-20756 |
Protein |
denotes |
NF-κB |
| T9495 |
20757-20767 |
Positive_regulation |
denotes |
activation |
| T9499 |
20757-20767 |
Positive_regulation |
denotes |
activation |
| T9494 |
20772-20775 |
Protein |
denotes |
IL1 |
| T9496 |
20776-20789 |
Transcription |
denotes |
transcription |
| T9500 |
20972-20979 |
Protein |
denotes |
SHARPIN |
| T9501 |
21050-21055 |
Protein |
denotes |
NF-κB |
| T9504 |
21083-21093 |
Positive_regulation |
denotes |
activation |
| T9502 |
21097-21102 |
Protein |
denotes |
NF-κB |
| T9503 |
21240-21245 |
Protein |
denotes |
NF-κB |
| T9508 |
21325-21335 |
Negative_regulation |
denotes |
inhibition |
| T9505 |
21339-21344 |
Protein |
denotes |
NF-κB |
| T9507 |
21345-21355 |
Positive_regulation |
denotes |
activation |
| T9506 |
21453-21458 |
Protein |
denotes |
NF-κB |
| T9509 |
21558-21563 |
Protein |
denotes |
NF-κB |
| T9510 |
21749-21756 |
Protein |
denotes |
Sharpin |
| T9511 |
21814-21821 |
Protein |
denotes |
SHARPIN |
| T9512 |
21857-21862 |
Protein |
denotes |
NF-κB |
| T9514 |
21863-21873 |
Positive_regulation |
denotes |
activation |
| T9516 |
21863-21873 |
Positive_regulation |
denotes |
activation |
| T9513 |
21892-21899 |
Protein |
denotes |
Sharpin |
| T9515 |
21900-21910 |
Gene_expression |
denotes |
expression |
| T9517 |
22031-22045 |
Protein |
denotes |
NF-κB subunits |
| T9518 |
22106-22111 |
Protein |
denotes |
NF-κB |
| T9524 |
22271-22278 |
Gene_expression |
denotes |
produce |
| T9519 |
22279-22282 |
Protein |
denotes |
p52 |
| T9520 |
22308-22315 |
Protein |
denotes |
SHARPIN |
| T9525 |
22316-22325 |
Negative_regulation |
denotes |
deficient |
| T9521 |
22361-22366 |
Protein |
denotes |
NF-κB |
| T9522 |
22379-22382 |
Protein |
denotes |
p52 |
| T9523 |
22383-22387 |
Protein |
denotes |
RELB |
| T9526 |
22503-22510 |
Protein |
denotes |
Sharpin |
| T9527 |
22535-22540 |
Protein |
denotes |
NF-κB |
| T9530 |
22656-22662 |
Binding |
denotes |
engage |
| T9528 |
22663-22667 |
Protein |
denotes |
TLR4 |
| T9529 |
22672-22676 |
Protein |
denotes |
TLR3 |
| T9534 |
22696-22706 |
Gene_expression |
denotes |
expression |
| T9531 |
22726-22730 |
Protein |
denotes |
TLR4 |
| T9532 |
22803-22808 |
Protein |
denotes |
NF-κB |
| T9535 |
22809-22819 |
Positive_regulation |
denotes |
activation |
| T9533 |
22852-22855 |
Protein |
denotes |
TLR |
| T9536 |
22856-22866 |
Gene_expression |
denotes |
expression |
| T9542 |
22888-22895 |
Positive_regulation |
denotes |
engages |
| T9537 |
22896-22900 |
Protein |
denotes |
TLR4 |
| T9538 |
22913-22918 |
Protein |
denotes |
MYD88 |
| T9539 |
22933-22937 |
Protein |
denotes |
TRIF |
| T9540 |
22966-22970 |
Protein |
denotes |
TLR3 |
| T9541 |
23008-23012 |
Protein |
denotes |
TRIF |
| T9543 |
23053-23058 |
Protein |
denotes |
NF-κB |
| T9547 |
23059-23069 |
Positive_regulation |
denotes |
activation |
| T9544 |
23104-23111 |
Protein |
denotes |
Sharpin |
| T9548 |
23121-23131 |
Binding |
denotes |
interferes |
| T9549 |
23121-23131 |
Binding |
denotes |
interferes |
| T9550 |
23121-23131 |
Binding |
denotes |
interferes |
| T9545 |
23212-23216 |
Protein |
denotes |
RIP1 |
| T9546 |
23221-23226 |
Protein |
denotes |
TRAF6 |
| T9551 |
23266-23273 |
Protein |
denotes |
SHARPIN |
| T9559 |
23274-23283 |
Binding |
denotes |
interacts |
| T9552 |
23331-23340 |
Protein |
denotes |
ubiquitin |
| T9553 |
23341-23346 |
Protein |
denotes |
chain |
| T9554 |
23347-23353 |
Protein |
denotes |
ligase |
| T9555 |
23366-23371 |
Protein |
denotes |
NF-κB |
| T9556 |
23390-23394 |
Protein |
denotes |
RIP1 |
| T9557 |
23438-23456 |
Protein |
denotes |
TNFα-stimulated NF |
| T9558 |
23457-23459 |
Protein |
denotes |
κB |
| T9560 |
23460-23470 |
Positive_regulation |
denotes |
activation |
| T9561 |
23460-23470 |
Positive_regulation |
denotes |
activation |
| T9562 |
23476-23483 |
Protein |
denotes |
Sharpin |
| T9563 |
23552-23556 |
Protein |
denotes |
TNFα |
| T9564 |
23565-23570 |
Protein |
denotes |
NF-κB |
| T9565 |
23596-23600 |
Protein |
denotes |
TNFR |
| T9566 |
23605-23608 |
Protein |
denotes |
TLR |
| T9570 |
23691-23701 |
Regulation |
denotes |
regulation |
| T9567 |
23720-23727 |
Protein |
denotes |
SHARPIN |
| T9568 |
23757-23762 |
Protein |
denotes |
NF-κB |
| T9569 |
23763-23773 |
Positive_regulation |
denotes |
activation |
| T9571 |
23841-23848 |
Protein |
denotes |
SHARPIN |
| T9573 |
23856-23866 |
Gene_expression |
denotes |
production |
| T9572 |
23913-23918 |
Protein |
denotes |
NF-κB |
| T9574 |
23943-23946 |
Protein |
denotes |
Th1 |
| T9575 |
23970-23977 |
Protein |
denotes |
Sharpin |
| T9576 |
23978-23987 |
Negative_regulation |
denotes |
deficient |
| T9937 |
24884-24886 |
Protein |
denotes |
WT |
| T9938 |
25077-25084 |
Protein |
denotes |
Sharpin |
| T10323 |
25475-25482 |
Protein |
denotes |
Sharpin |
| T10324 |
25598-25609 |
Protein |
denotes |
CCG CCC GCC |
| T10325 |
25610-25617 |
Protein |
denotes |
GGC GGT |
| T10326 |
25632-25643 |
Protein |
denotes |
AAG CTT CTA |
| T10327 |
25644-25669 |
Protein |
denotes |
GGT GGA AGC TGC AGC AAG A |
| T10328 |
25675-25687 |
Protein |
denotes |
Sharpin cDNA |
| T10330 |
25788-25795 |
Gene_expression |
denotes |
express |
| T10329 |
25796-25823 |
Protein |
denotes |
recombinant SHARPIN protein |
| T10331 |
26133-26137 |
Protein |
denotes |
FLAG |
| T10332 |
26138-26145 |
Protein |
denotes |
SHARPIN |
| T10333 |
26146-26156 |
Gene_expression |
denotes |
expression |
| T10334 |
26146-26156 |
Gene_expression |
denotes |
expression |
| T10925 |
26830-26835 |
Protein |
denotes |
CD11c |
| T10926 |
26837-26845 |
Protein |
denotes |
MCD11C20 |
| T10927 |
26985-26992 |
Protein |
denotes |
PE-anti |
| T10928 |
26993-26997 |
Protein |
denotes |
CD14 |
| T10929 |
27171-27180 |
Protein |
denotes |
avidin-PE |
| T10930 |
27218-27229 |
Protein |
denotes |
collagenase |
| T10931 |
27358-27363 |
Protein |
denotes |
CD11c |
| T10932 |
27365-27368 |
Protein |
denotes |
HL3 |
| T10933 |
27419-27428 |
Protein |
denotes |
FITC-anti |
| T10934 |
27429-27433 |
Protein |
denotes |
CD8α |
| T11296 |
27958-27962 |
Protein |
denotes |
CD4+ |
| T11301 |
28168-28177 |
Localization |
denotes |
secretion |
| T11302 |
28168-28177 |
Localization |
denotes |
secretion |
| T11303 |
28168-28177 |
Localization |
denotes |
secretion |
| T11304 |
28168-28177 |
Localization |
denotes |
secretion |
| T11297 |
28181-28185 |
Protein |
denotes |
IFNγ |
| T11298 |
28187-28190 |
Protein |
denotes |
IL4 |
| T11299 |
28192-28195 |
Protein |
denotes |
IL2 |
| T11300 |
28201-28206 |
Protein |
denotes |
IL17A |
| T11906 |
28661-28664 |
Protein |
denotes |
TRI |
| T11910 |
28731-28741 |
Gene_expression |
denotes |
expression |
| T11911 |
28731-28741 |
Gene_expression |
denotes |
expression |
| T11912 |
28731-28741 |
Gene_expression |
denotes |
expression |
| T11907 |
28745-28748 |
Protein |
denotes |
Il6 |
| T11908 |
28750-28757 |
Protein |
denotes |
Il12p40 |
| T11909 |
28770-28782 |
Protein |
denotes |
Sharpin mRNA |
| T11913 |
29063-29082 |
Protein |
denotes |
RNasin Ribonuclease |
| T11914 |
29098-29125 |
Protein |
denotes |
M-MLV Reverse Transcriptase |
| T11915 |
29460-29464 |
Protein |
denotes |
Actb |
| T11916 |
29466-29469 |
Protein |
denotes |
IL6 |
| T11917 |
29471-29478 |
Protein |
denotes |
IL12p40 |
| T11918 |
29480-29484 |
Protein |
denotes |
Ifnβ |
| T11919 |
29497-29504 |
Protein |
denotes |
Sharpin |
| T11920 |
29612-29619 |
Protein |
denotes |
β-actin |
| T12079 |
29841-29866 |
Protein |
denotes |
RPMI-1640 complete medium |
| T12672 |
31033-31039 |
Protein |
denotes |
p-IκBα |
| T12673 |
31049-31053 |
Protein |
denotes |
IκBα |
| T12674 |
31065-31069 |
Protein |
denotes |
TBK1 |
| T12675 |
31080-31083 |
Protein |
denotes |
p38 |
| T12676 |
31093-31096 |
Protein |
denotes |
p38 |
| T12677 |
31144-31148 |
Protein |
denotes |
Beta |
| T12678 |
31149-31154 |
Protein |
denotes |
actin |
| R11003 |
T13253 |
T13254 |
themeOf |
WT BMDC,expression |
| R11889 |
T14232 |
T14233 |
themeOf |
IL12P70,production |
| R12530 |
T14953 |
T14956 |
themeOf |
TLR4,expression |
| R12531 |
T14954 |
T14957 |
themeOf |
MD2,expression |
| R12532 |
T14955 |
T14960 |
themeOf |
IL10,secretion |
| R12533 |
T14956 |
T14958 |
themeOf |
expression,decreased |
| R12534 |
T14957 |
T14959 |
themeOf |
expression,decreased |
| R12535 |
T14960 |
T14961 |
themeOf |
secretion,decreased |
| R12536 |
T14967 |
T14968 |
themeOf |
A20,production |
| R12792 |
T15303 |
T15304 |
themeOf |
NF-κB,Inhibition |
| R12793 |
T15312 |
T15315 |
themeOf |
p-IκBα,levels |
| R13166 |
T15737 |
T15740 |
themeOf |
IFNγ,secretion |
| R13167 |
T15738 |
T15741 |
themeOf |
IL4,secretion |
| R13168 |
T15739 |
T15742 |
themeOf |
IL2,secretion |
| R1773 |
T2135 |
T2136 |
themeOf |
SHARPIN,expressed |
| R1776 |
T2138 |
T2140 |
themeOf |
IFNγ [5],secretion |
| R1778 |
T2140 |
T2141 |
themeOf |
secretion,decreased |
| R1779 |
T2144 |
T2145 |
themeOf |
IL5,deficient |
| R1780 |
T2149 |
T2151 |
themeOf |
SHARPIN,deficient |
| R1781 |
T2153 |
T2154 |
themeOf |
SHARPIN,deficient |
| R1782 |
T2155 |
T2157 |
themeOf |
SHARPIN protein,lack |
| R1783 |
T2156 |
T2158 |
themeOf |
NF-κB,activation |
| R1784 |
T2157 |
T2159 |
causeOf |
lack,impaired |
| R1785 |
T2158 |
T2159 |
themeOf |
activation,impaired |
| R1786 |
T2160 |
T2161 |
themeOf |
Th1,production |
| R1787 |
T2161 |
T2162 |
themeOf |
production,stimulate |
| R1788 |
T2164 |
T2165 |
themeOf |
SHARPIN,deficient |
| R2284 |
T2772 |
T2776 |
partOf |
SHARPIN,domain |
| R2285 |
T2774 |
T2776 |
partOf |
zinc-finger Ran-binding protein 2,domain |
| R2286 |
T2775 |
T2776 |
partOf |
ZFRBP,domain |
| R2287 |
T2777 |
T2779 |
themeOf |
SHARPIN protein,present |
| R2288 |
T2781 |
T2782 |
themeOf |
Sharpin,expression |
| R2289 |
T2783 |
T2784 |
themeOf |
Sharpin mRNA,decreased |
| R2290 |
T2785 |
T2786 |
themeOf |
Sharpin mRNA,reduction |
| R2291 |
T2787 |
T2790 |
themeOf |
Sharpin,Transfection |
| R2292 |
T2788 |
T2793 |
themeOf |
SHARPIN protein,localization |
| R2293 |
T2789 |
T2794 |
themeOf |
Fig. 1E,localization |
| R2294 |
T2790 |
T2791 |
themeOf |
Transfection,Transfection |
| R2295 |
T2792 |
T2793 |
locationOf |
cytoplasmic,localization |
| R2296 |
T2792 |
T2794 |
locationOf |
cytoplasmic,localization |
| R3530 |
T4265 |
T4270 |
themeOf |
IL6,secretion |
| R3531 |
T4266 |
T4271 |
themeOf |
IL12P70,secretion |
| R3532 |
T4267 |
T4272 |
themeOf |
GMCSF,secretion |
| R3533 |
T4268 |
T4273 |
themeOf |
WT BMDC,produced |
| R3534 |
T4269 |
T4274 |
themeOf |
Fig,produced |
| R3535 |
T4270 |
T4275 |
themeOf |
secretion,resulted |
| R3536 |
T4271 |
T4276 |
themeOf |
secretion,resulted |
| R3537 |
T4272 |
T4277 |
themeOf |
secretion,resulted |
| R3538 |
T4278 |
T4279 |
themeOf |
Sharpin,deficient |
| R3539 |
T4281 |
T4284 |
themeOf |
IL12P70,secreted |
| R3540 |
T4282 |
T4286 |
causeOf |
SHARPIN,role |
| R3541 |
T4283 |
T4285 |
themeOf |
IL12P70,production |
| R3542 |
T4285 |
T4286 |
themeOf |
production,role |
| R3543 |
T4287 |
T4289 |
themeOf |
cytokines Il6,levels |
| R3544 |
T4288 |
T4290 |
themeOf |
Il12p40,levels |
| R3545 |
T4289 |
T4291 |
themeOf |
levels,reduced |
| R3546 |
T4290 |
T4292 |
themeOf |
levels,reduced |
| R4542 |
T5634 |
T5635 |
themeOf |
TLR,expression |
| R4543 |
T5635 |
T5636 |
themeOf |
expression,increased |
| R4544 |
T5637 |
T5643 |
themeOf |
LPS receptor,expression |
| R4545 |
T5638 |
T5644 |
themeOf |
TLR4,expression |
| R4546 |
T5645 |
T5648 |
themeOf |
CD14,expression |
| R4547 |
T5646 |
T5649 |
themeOf |
TLR4,expression |
| R4548 |
T5647 |
T5650 |
themeOf |
MD2,expression |
| R4549 |
T5651 |
T5653 |
themeOf |
cytokines IL10,secretion |
| R4550 |
T5651 |
T5655 |
causeOf |
cytokines IL10,inhibit |
| R4551 |
T5652 |
T5654 |
themeOf |
IL12,secretion |
| R4552 |
T5654 |
T5655 |
themeOf |
secretion,inhibit |
| R4553 |
T5656 |
T5659 |
themeOf |
IL10,stimulated |
| R4554 |
T5657 |
T5661 |
causeOf |
IL10,responsible |
| R4555 |
T5658 |
T5660 |
themeOf |
IL12P70,secretion |
| R4556 |
T5660 |
T5661 |
themeOf |
secretion,responsible |
| R4557 |
T5660 |
T5662 |
themeOf |
secretion,decreased |
| R4558 |
T5663 |
T5664 |
themeOf |
TLR,expression |
| R4559 |
T5664 |
T5665 |
themeOf |
expression,Increased |
| R4560 |
T5667 |
T5668 |
themeOf |
A20,overexpression |
| R4561 |
T5668 |
T5669 |
themeOf |
overexpression,overexpression |
| R4562 |
T5668 |
T5670 |
themeOf |
overexpression,ruling |
| R4563 |
T5669 |
T5671 |
themeOf |
overexpression,ruling |
| R4564 |
T5673 |
T5676 |
themeOf |
NF-κB,regulated |
| R4565 |
T5674 |
T5677 |
themeOf |
TBK1,regulated |
| R4566 |
T5675 |
T5678 |
themeOf |
IRF3,regulated |
| R4567 |
T5683 |
T5684 |
themeOf |
Sharpin,deficient |
| R4568 |
T5685 |
T5691 |
themeOf |
IκB kinase,phosphorylation |
| R4569 |
T5686 |
T5692 |
themeOf |
IKK1/2,phosphorylation |
| R4570 |
T5686 |
T5695 |
themeOf |
IKK1/2,degradation |
| R4571 |
T5688 |
T5693 |
themeOf |
NF-κB,phosphorylation |
| R4572 |
T5688 |
T5696 |
themeOf |
NF-κB,degradation |
| R4573 |
T5689 |
T5694 |
themeOf |
IκBα,phosphorylation |
| R4574 |
T5689 |
T5697 |
themeOf |
IκBα,degradation |
| R4575 |
T5690 |
T5707 |
themeOf |
NF-κB transcription factors,release |
| R4576 |
T5691 |
T5699 |
themeOf |
phosphorylation,Stimulus-induced |
| R4577 |
T5692 |
T5700 |
themeOf |
phosphorylation,Stimulus-induced |
| R4578 |
T5695 |
T5701 |
themeOf |
degradation,allowing |
| R4579 |
T5695 |
T5704 |
themeOf |
degradation,proteasome-mediated |
| R4580 |
T5696 |
T5702 |
themeOf |
degradation,allowing |
| R4581 |
T5696 |
T5705 |
themeOf |
degradation,proteasome-mediated |
| R4582 |
T5697 |
T5703 |
themeOf |
degradation,allowing |
| R4583 |
T5697 |
T5706 |
themeOf |
degradation,proteasome-mediated |
| R4584 |
T5698 |
T5707 |
locationOf |
nucleus,release |
| R4585 |
T5708 |
T5711 |
themeOf |
TBK1,levels |
| R4586 |
T5708 |
T5713 |
themeOf |
TBK1,phosphorylation |
| R4587 |
T5709 |
T5712 |
themeOf |
ERK1/2,levels |
| R4588 |
T5709 |
T5714 |
themeOf |
ERK1/2,phosphorylation |
| R4589 |
T5710 |
T5715 |
themeOf |
p38,phosphorylation |
| R4590 |
T5711 |
T5716 |
themeOf |
levels,exhibited |
| R4591 |
T5712 |
T5717 |
themeOf |
levels,exhibited |
| R4592 |
T5713 |
T5718 |
themeOf |
phosphorylation,levels |
| R4593 |
T5714 |
T5719 |
themeOf |
phosphorylation,levels |
| R4594 |
T5715 |
T5720 |
themeOf |
phosphorylation,levels |
| R4595 |
T5721 |
T5727 |
themeOf |
SHARPIN decreased NF,absence |
| R4596 |
T5722 |
T5728 |
themeOf |
κB,activation |
| R4597 |
T5723 |
T5729 |
themeOf |
TBK1,affect |
| R4598 |
T5724 |
T5730 |
themeOf |
IRF3,affect |
| R4599 |
T5725 |
T5731 |
themeOf |
ERK1,affect |
| R4600 |
T5727 |
T5729 |
causeOf |
absence,affect |
| R4601 |
T5727 |
T5730 |
causeOf |
absence,affect |
| R4602 |
T5727 |
T5731 |
causeOf |
absence,affect |
| R5313 |
T6553 |
T6555 |
themeOf |
IL12,production |
| R5314 |
T6555 |
T6556 |
themeOf |
production,defective |
| R5315 |
T6562 |
T6564 |
themeOf |
Th1,induce |
| R5316 |
T6563 |
T6565 |
themeOf |
Th2,induce |
| R5317 |
T6566 |
T6569 |
causeOf |
WT BMDC,induced |
| R5318 |
T6567 |
T6568 |
themeOf |
robust IFNγ,production |
| R5319 |
T6568 |
T6569 |
themeOf |
production,induced |
| R5320 |
T6570 |
T6573 |
themeOf |
Th1,reduced |
| R5321 |
T6571 |
T6574 |
themeOf |
IL12,production |
| R5322 |
T6574 |
T6575 |
themeOf |
production,report |
| R5323 |
T6574 |
T6576 |
themeOf |
production,decreased |
| R5324 |
T6578 |
T6579 |
themeOf |
Th17-specific cytokine IL17A,production |
| R5325 |
T6581 |
T6584 |
themeOf |
IL2,production |
| R5326 |
T6582 |
T6585 |
causeOf |
WT BMDC,induced |
| R5327 |
T6583 |
T6585 |
themeOf |
IL2,induced |
| R5328 |
T6584 |
T6586 |
themeOf |
production,effective |
| R7796 |
T9454 |
T9455 |
themeOf |
mouse Sharpin gene,affect |
| R7798 |
T9543 |
T9547 |
themeOf |
NF-κB,activation |
| R7799 |
T9544 |
T9548 |
themeOf |
Sharpin,interferes |
| R7800 |
T9544 |
T9549 |
themeOf |
Sharpin,interferes |
| R7801 |
T9544 |
T9550 |
themeOf |
Sharpin,interferes |
| R7802 |
T9545 |
T9549 |
themeOf |
RIP1,interferes |
| R7803 |
T9546 |
T9550 |
themeOf |
TRAF6,interferes |
| R7804 |
T9551 |
T9559 |
themeOf |
SHARPIN,interacts |
| R7805 |
T9461 |
T9462 |
themeOf |
SHARPIN,deficiency |
| R7806 |
T9464 |
T9466 |
themeOf |
DAMPs,release |
| R7807 |
T9465 |
T9467 |
themeOf |
HMGB1,recognized |
| R7808 |
T9557 |
T9560 |
themeOf |
TNFα-stimulated NF,activation |
| R7809 |
T9471 |
T9472 |
themeOf |
IL12P70,production |
| R7810 |
T9472 |
T9473 |
themeOf |
production,reduced |
| R7811 |
T9474 |
T9476 |
themeOf |
IL12P70,importance |
| R7812 |
T9558 |
T9561 |
themeOf |
κB,activation |
| R7813 |
T9568 |
T9569 |
themeOf |
NF-κB,activation |
| R7814 |
T9481 |
T9487 |
themeOf |
NF-κB,activation |
| R7815 |
T9482 |
T9489 |
themeOf |
TBK1,activation |
| R7816 |
T9483 |
T9490 |
themeOf |
IRF3,activation |
| R7817 |
T9484 |
T9491 |
themeOf |
ERK1,activation |
| R7818 |
T9485 |
T9492 |
themeOf |
p38,activation |
| R7819 |
T9487 |
T9488 |
themeOf |
activation,inhibited |
| R7820 |
T9493 |
T9495 |
themeOf |
NF-κB,activation |
| R7821 |
T9494 |
T9496 |
themeOf |
IL1,transcription |
| R7822 |
T9569 |
T9570 |
themeOf |
activation,regulation |
| R7823 |
T9495 |
T9497 |
themeOf |
activation,increased |
| R7824 |
T9496 |
T9498 |
themeOf |
transcription,increased |
| R7825 |
T9496 |
T9499 |
themeOf |
transcription,activation |
| R7826 |
T9571 |
T9573 |
themeOf |
SHARPIN,production |
| R7827 |
T9575 |
T9576 |
themeOf |
Sharpin,deficient |
| R7828 |
T9502 |
T9504 |
themeOf |
NF-κB,activation |
| R7829 |
T9505 |
T9507 |
themeOf |
NF-κB,activation |
| R7830 |
T9507 |
T9508 |
themeOf |
activation,inhibition |
| R7831 |
T9512 |
T9514 |
themeOf |
NF-κB,activation |
| R7832 |
T9513 |
T9515 |
themeOf |
Sharpin,expression |
| R7833 |
T9515 |
T9516 |
themeOf |
expression,activation |
| R7834 |
T9519 |
T9524 |
themeOf |
p52,produce |
| R7835 |
T9520 |
T9525 |
themeOf |
SHARPIN,deficient |
| R7836 |
T9529 |
T9530 |
themeOf |
TLR3,engage |
| R7837 |
T9531 |
T9534 |
themeOf |
TLR4,expression |
| R7838 |
T9532 |
T9535 |
themeOf |
NF-κB,activation |
| R7839 |
T9533 |
T9536 |
themeOf |
TLR,expression |
| R7840 |
T9537 |
T9542 |
themeOf |
TLR4,engages |
| R8507 |
T10329 |
T10330 |
themeOf |
recombinant SHARPIN protein,express |
| R8508 |
T10331 |
T10333 |
themeOf |
FLAG,expression |
| R8509 |
T10332 |
T10334 |
themeOf |
SHARPIN,expression |
| R9380 |
T11297 |
T11301 |
themeOf |
IFNγ,secretion |
| R9381 |
T11298 |
T11302 |
themeOf |
IL4,secretion |
| R9382 |
T11299 |
T11303 |
themeOf |
IL2,secretion |
| R9383 |
T11300 |
T11304 |
themeOf |
IL17A,secretion |
| R9881 |
T11907 |
T11910 |
themeOf |
Il6,expression |
| R9882 |
T11908 |
T11911 |
themeOf |
Il12p40,expression |
| R9883 |
T11909 |
T11912 |
themeOf |
Sharpin mRNA,expression |
