| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T838 |
0-7 |
Protein |
denotes |
SHARPIN |
| T839 |
46-51 |
Protein |
denotes |
NF-κB |
| T847 |
177-186 |
Gene_expression |
denotes |
mutations |
| T848 |
177-186 |
Gene_expression |
denotes |
mutations |
| T849 |
177-186 |
Gene_expression |
denotes |
mutations |
| T850 |
177-186 |
Gene_expression |
denotes |
mutations |
| T840 |
194-201 |
Protein |
denotes |
Sharpin |
| T841 |
203-208 |
Protein |
denotes |
SHANK |
| T851 |
209-219 |
Gene_expression |
denotes |
associated |
| T852 |
209-219 |
Gene_expression |
denotes |
associated |
| T853 |
209-219 |
Gene_expression |
denotes |
associated |
| T854 |
209-219 |
Gene_expression |
denotes |
associated |
| T842 |
220-222 |
Protein |
denotes |
RH |
| T843 |
266-272 |
Protein |
denotes |
Rbckl1 |
| T844 |
274-279 |
Protein |
denotes |
Sipl1 |
| T857 |
388-400 |
Regulation |
denotes |
dysregulated |
| T858 |
388-400 |
Regulation |
denotes |
dysregulated |
| T855 |
401-410 |
Localization |
denotes |
secretion |
| T856 |
401-410 |
Localization |
denotes |
secretion |
| T845 |
414-423 |
Protein |
denotes |
T helper1 |
| T846 |
425-428 |
Protein |
denotes |
Th1 |
| T859 |
627-634 |
Protein |
denotes |
SHARPIN |
| T860 |
635-644 |
Negative_regulation |
denotes |
deficient |
| T861 |
749-756 |
Protein |
denotes |
SHARPIN |
| T862 |
758-768 |
Negative_regulation |
denotes |
deficiency |
| T863 |
855-873 |
Protein |
denotes |
TOLL-like receptor |
| T864 |
875-878 |
Protein |
denotes |
TLR |
| T871 |
1001-1010 |
Positive_regulation |
denotes |
increases |
| T872 |
1001-1010 |
Positive_regulation |
denotes |
increases |
| T873 |
1001-1010 |
Positive_regulation |
denotes |
increases |
| T868 |
1014-1024 |
Gene_expression |
denotes |
expression |
| T869 |
1014-1024 |
Gene_expression |
denotes |
expression |
| T870 |
1014-1024 |
Gene_expression |
denotes |
expression |
| T865 |
1053-1057 |
Protein |
denotes |
CD40 |
| T866 |
1059-1063 |
Protein |
denotes |
CD80 |
| T867 |
1069-1073 |
Protein |
denotes |
CD86 |
| T874 |
1095-1102 |
Protein |
denotes |
SHARPIN |
| T878 |
1103-1112 |
Negative_regulation |
denotes |
deficient |
| T885 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
| T886 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
| T887 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
| T879 |
1130-1143 |
Transcription |
denotes |
transcription |
| T880 |
1130-1143 |
Transcription |
denotes |
transcription |
| T881 |
1130-1143 |
Transcription |
denotes |
transcription |
| T882 |
1148-1157 |
Localization |
denotes |
secretion |
| T883 |
1148-1157 |
Localization |
denotes |
secretion |
| T884 |
1148-1157 |
Localization |
denotes |
secretion |
| T875 |
1188-1191 |
Protein |
denotes |
IL6 |
| T876 |
1193-1200 |
Protein |
denotes |
IL12P70 |
| T877 |
1202-1207 |
Protein |
denotes |
GMCSF |
| T893 |
1253-1263 |
Positive_regulation |
denotes |
activation |
| T888 |
1267-1272 |
Protein |
denotes |
NF-κB |
| T889 |
1296-1303 |
Protein |
denotes |
MAPK1/3 |
| T890 |
1305-1309 |
Protein |
denotes |
ERK1 |
| T891 |
1334-1357 |
Protein |
denotes |
p38 MAP kinase isoforms |
| T892 |
1363-1367 |
Protein |
denotes |
TBK1 |
| T894 |
1563-1567 |
Protein |
denotes |
CD4+ |
| T896 |
1592-1596 |
Negative_regulation |
denotes |
loss |
| T895 |
1600-1607 |
Protein |
denotes |
Sharpin |
| T2135 |
1771-1778 |
Protein |
denotes |
SHARPIN |
| T2136 |
1908-1917 |
Gene_expression |
denotes |
expressed |
| T2137 |
1997-2009 |
Protein |
denotes |
Sharpin gene |
| T2141 |
2866-2875 |
Negative_regulation |
denotes |
decreased |
| T2140 |
2876-2885 |
Localization |
denotes |
secretion |
| T2138 |
2889-2897 |
Protein |
denotes |
IFNγ [5] |
| T2139 |
2922-2925 |
Protein |
denotes |
Th1 |
| T2142 |
3034-3038 |
Protein |
denotes |
IL12 |
| T2143 |
3106-3109 |
Protein |
denotes |
IL5 |
| T2144 |
3148-3151 |
Protein |
denotes |
IL5 |
| T2145 |
3152-3161 |
Negative_regulation |
denotes |
deficient |
| T2146 |
3341-3348 |
Protein |
denotes |
SHARPIN |
| T2147 |
3445-3449 |
Protein |
denotes |
TNFα |
| T2148 |
3468-3473 |
Protein |
denotes |
NF-κB |
| T2149 |
3493-3500 |
Protein |
denotes |
SHARPIN |
| T2151 |
3501-3510 |
Negative_regulation |
denotes |
deficient |
| T2150 |
3563-3567 |
Protein |
denotes |
TNFα |
| T2152 |
4004-4008 |
Protein |
denotes |
CD4+ |
| T2153 |
4215-4222 |
Protein |
denotes |
SHARPIN |
| T2154 |
4223-4232 |
Negative_regulation |
denotes |
deficient |
| T2157 |
4276-4280 |
Negative_regulation |
denotes |
lack |
| T2155 |
4284-4299 |
Protein |
denotes |
SHARPIN protein |
| T2159 |
4370-4378 |
Negative_regulation |
denotes |
impaired |
| T2156 |
4379-4384 |
Protein |
denotes |
NF-κB |
| T2158 |
4385-4395 |
Positive_regulation |
denotes |
activation |
| T2162 |
4449-4458 |
Positive_regulation |
denotes |
stimulate |
| T2160 |
4459-4462 |
Protein |
denotes |
Th1 |
| T2161 |
4472-4482 |
Gene_expression |
denotes |
production |
| T2163 |
4569-4576 |
Protein |
denotes |
SHARPIN |
| T2164 |
4668-4675 |
Protein |
denotes |
SHARPIN |
| T2165 |
4676-4685 |
Negative_regulation |
denotes |
deficient |
| T2771 |
4777-4792 |
Protein |
denotes |
SHARPIN protein |
| T2772 |
4936-4943 |
Protein |
denotes |
SHARPIN |
| T2773 |
4982-4991 |
Protein |
denotes |
ubiquitin |
| T2774 |
5017-5050 |
Protein |
denotes |
zinc-finger Ran-binding protein 2 |
| T2775 |
5052-5057 |
Protein |
denotes |
ZFRBP |
| T2776 |
5059-5065 |
Entity |
denotes |
domain |
| T2779 |
5135-5142 |
Gene_expression |
denotes |
present |
| T2777 |
5150-5165 |
Protein |
denotes |
SHARPIN protein |
| T2778 |
5214-5221 |
Protein |
denotes |
SHARPIN |
| T2780 |
5307-5319 |
Protein |
denotes |
Sharpin gene |
| T2782 |
5524-5534 |
Transcription |
denotes |
expression |
| T2781 |
5538-5545 |
Protein |
denotes |
Sharpin |
| T2783 |
5678-5690 |
Protein |
denotes |
Sharpin mRNA |
| T2784 |
5771-5780 |
Negative_regulation |
denotes |
decreased |
| T2786 |
5825-5834 |
Negative_regulation |
denotes |
reduction |
| T2785 |
5838-5850 |
Protein |
denotes |
Sharpin mRNA |
| T2790 |
5896-5908 |
Gene_expression |
denotes |
Transfection |
| T2791 |
5896-5908 |
Positive_regulation |
denotes |
Transfection |
| T2787 |
5924-5931 |
Protein |
denotes |
Sharpin |
| T2792 |
5993-6004 |
Entity |
denotes |
cytoplasmic |
| T2793 |
6005-6017 |
Localization |
denotes |
localization |
| T2794 |
6005-6017 |
Localization |
denotes |
localization |
| T2788 |
6025-6040 |
Protein |
denotes |
SHARPIN protein |
| T2789 |
6042-6049 |
Protein |
denotes |
Fig. 1E |
| T13246 |
6129-6136 |
Protein |
denotes |
SHARPIN |
| T13247 |
6233-6236 |
Protein |
denotes |
UBL |
| T13248 |
6238-6247 |
Protein |
denotes |
ubiquitin |
| T13249 |
6265-6270 |
Protein |
denotes |
ZFRBP |
| T13250 |
6272-6305 |
Protein |
denotes |
zinc-finger Ran-Binding protein 2 |
| T13251 |
6355-6370 |
Protein |
denotes |
SHARPIN protein |
| T13252 |
6730-6737 |
Protein |
denotes |
Sharpin |
| T13254 |
6797-6807 |
Transcription |
denotes |
expression |
| T13253 |
6826-6833 |
Protein |
denotes |
WT BMDC |
| T13255 |
7178-7182 |
Protein |
denotes |
FLAG |
| T13256 |
7183-7190 |
Protein |
denotes |
SHARPIN |
| T4275 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
| T4276 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
| T4277 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
| T4270 |
10438-10447 |
Localization |
denotes |
secretion |
| T4271 |
10438-10447 |
Localization |
denotes |
secretion |
| T4272 |
10438-10447 |
Localization |
denotes |
secretion |
| T4265 |
10451-10454 |
Protein |
denotes |
IL6 |
| T4266 |
10456-10463 |
Protein |
denotes |
IL12P70 |
| T4267 |
10469-10474 |
Protein |
denotes |
GMCSF |
| T4273 |
10532-10540 |
Gene_expression |
denotes |
produced |
| T4274 |
10532-10540 |
Gene_expression |
denotes |
produced |
| T4268 |
10597-10604 |
Protein |
denotes |
WT BMDC |
| T4269 |
10606-10609 |
Protein |
denotes |
Fig |
| T4278 |
10815-10822 |
Protein |
denotes |
Sharpin |
| T4279 |
10823-10832 |
Negative_regulation |
denotes |
deficient |
| T4280 |
10870-10877 |
Protein |
denotes |
Sharpin |
| T4284 |
10988-10996 |
Localization |
denotes |
secreted |
| T4281 |
11016-11023 |
Protein |
denotes |
IL12P70 |
| T4286 |
11083-11087 |
Positive_regulation |
denotes |
role |
| T4282 |
11091-11098 |
Protein |
denotes |
SHARPIN |
| T4285 |
11107-11117 |
Gene_expression |
denotes |
production |
| T4283 |
11121-11128 |
Protein |
denotes |
IL12P70 |
| T4289 |
11158-11164 |
Transcription |
denotes |
levels |
| T4290 |
11158-11164 |
Transcription |
denotes |
levels |
| T4287 |
11185-11198 |
Protein |
denotes |
cytokines Il6 |
| T4288 |
11200-11207 |
Protein |
denotes |
Il12p40 |
| T4291 |
11273-11280 |
Negative_regulation |
denotes |
reduced |
| T4292 |
11273-11280 |
Negative_regulation |
denotes |
reduced |
| T14226 |
11670-11677 |
Protein |
denotes |
IL12P70 |
| T14227 |
11679-11682 |
Protein |
denotes |
IL6 |
| T14228 |
11688-11693 |
Protein |
denotes |
GMCSF |
| T14229 |
11900-11907 |
Protein |
denotes |
IL12P70 |
| T14230 |
11912-11915 |
Protein |
denotes |
IL6 |
| T14231 |
11981-12003 |
Protein |
denotes |
Sharpin-containing BAC |
| T14232 |
12240-12247 |
Protein |
denotes |
IL12P70 |
| T14233 |
12248-12258 |
Gene_expression |
denotes |
production |
| T14538 |
12662-12665 |
Protein |
denotes |
qRT |
| T5633 |
12924-12929 |
Protein |
denotes |
NF-κB |
| T5636 |
13174-13183 |
Positive_regulation |
denotes |
increased |
| T5635 |
13184-13194 |
Gene_expression |
denotes |
expression |
| T5634 |
13221-13224 |
Protein |
denotes |
TLR |
| T5643 |
13311-13321 |
Gene_expression |
denotes |
expression |
| T5644 |
13311-13321 |
Gene_expression |
denotes |
expression |
| T5637 |
13329-13341 |
Protein |
denotes |
LPS receptor |
| T5638 |
13365-13369 |
Protein |
denotes |
TLR4 |
| T5639 |
13394-13398 |
Protein |
denotes |
CD14 |
| T5640 |
13403-13435 |
Protein |
denotes |
myeloid differentiation factor 2 |
| T5641 |
13437-13440 |
Protein |
denotes |
MD2 |
| T5642 |
13441-13445 |
Protein |
denotes |
LY96 |
| T5648 |
13493-13503 |
Gene_expression |
denotes |
expression |
| T5649 |
13493-13503 |
Gene_expression |
denotes |
expression |
| T5650 |
13493-13503 |
Gene_expression |
denotes |
expression |
| T5645 |
13514-13518 |
Protein |
denotes |
CD14 |
| T5646 |
13523-13527 |
Protein |
denotes |
TLR4 |
| T5647 |
13528-13531 |
Protein |
denotes |
MD2 |
| T5653 |
13604-13613 |
Localization |
denotes |
secretion |
| T5651 |
13633-13647 |
Protein |
denotes |
cytokines IL10 |
| T5655 |
13657-13664 |
Negative_regulation |
denotes |
inhibit |
| T5652 |
13665-13669 |
Protein |
denotes |
IL12 |
| T5654 |
13670-13679 |
Localization |
denotes |
secretion |
| T5656 |
13802-13806 |
Protein |
denotes |
IL10 |
| T5659 |
13812-13822 |
Positive_regulation |
denotes |
stimulated |
| T5657 |
13858-13862 |
Protein |
denotes |
IL10 |
| T5661 |
13871-13882 |
Positive_regulation |
denotes |
responsible |
| T5662 |
13887-13896 |
Negative_regulation |
denotes |
decreased |
| T5660 |
13897-13906 |
Localization |
denotes |
secretion |
| T5658 |
13910-13917 |
Protein |
denotes |
IL12P70 |
| T5665 |
13932-13941 |
Positive_regulation |
denotes |
Increased |
| T5664 |
13942-13952 |
Gene_expression |
denotes |
expression |
| T5663 |
13980-13983 |
Protein |
denotes |
TLR |
| T5666 |
14082-14085 |
Protein |
denotes |
A20 |
| T5670 |
14159-14165 |
Positive_regulation |
denotes |
ruling |
| T5671 |
14159-14165 |
Positive_regulation |
denotes |
ruling |
| T5668 |
14170-14184 |
Gene_expression |
denotes |
overexpression |
| T5669 |
14170-14184 |
Positive_regulation |
denotes |
overexpression |
| T5667 |
14188-14191 |
Protein |
denotes |
A20 |
| T14953 |
14291-14295 |
Protein |
denotes |
TLR4 |
| T14954 |
14300-14303 |
Protein |
denotes |
MD2 |
| T14956 |
14304-14314 |
Gene_expression |
denotes |
expression |
| T14957 |
14304-14314 |
Gene_expression |
denotes |
expression |
| T14958 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
| T14959 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
| T14961 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
| T14955 |
14329-14333 |
Protein |
denotes |
IL10 |
| T14960 |
14334-14343 |
Localization |
denotes |
secretion |
| T14962 |
14453-14457 |
Protein |
denotes |
TLR4 |
| T14963 |
14458-14461 |
Protein |
denotes |
MD2 |
| T14964 |
14470-14474 |
Protein |
denotes |
CD14 |
| T14965 |
14764-14768 |
Protein |
denotes |
IL10 |
| T14966 |
14969-14972 |
Protein |
denotes |
qRT |
| T14968 |
14992-15002 |
Gene_expression |
denotes |
production |
| T14967 |
15006-15009 |
Protein |
denotes |
A20 |
| T5672 |
15035-15039 |
Protein |
denotes |
TLR3 |
| T5676 |
15091-15100 |
Regulation |
denotes |
regulated |
| T5677 |
15091-15100 |
Regulation |
denotes |
regulated |
| T5678 |
15091-15100 |
Regulation |
denotes |
regulated |
| T5673 |
15147-15152 |
Protein |
denotes |
NF-κB |
| T5674 |
15154-15158 |
Protein |
denotes |
TBK1 |
| T5675 |
15159-15163 |
Protein |
denotes |
IRF3 |
| T5679 |
15217-15222 |
Protein |
denotes |
NF-κB |
| T5680 |
15224-15228 |
Protein |
denotes |
TBK1 |
| T5681 |
15229-15233 |
Protein |
denotes |
IRF3 |
| T5682 |
15242-15246 |
Protein |
denotes |
MAPK |
| T5683 |
15319-15326 |
Protein |
denotes |
Sharpin |
| T5684 |
15327-15336 |
Negative_regulation |
denotes |
deficient |
| T5699 |
15343-15359 |
Positive_regulation |
denotes |
Stimulus-induced |
| T5700 |
15343-15359 |
Positive_regulation |
denotes |
Stimulus-induced |
| T5691 |
15360-15375 |
Phosphorylation |
denotes |
phosphorylation |
| T5692 |
15360-15375 |
Phosphorylation |
denotes |
phosphorylation |
| T5685 |
15383-15393 |
Protein |
denotes |
IκB kinase |
| T5686 |
15395-15401 |
Protein |
denotes |
IKK1/2 |
| T5687 |
15427-15432 |
Protein |
denotes |
NF-κB |
| T5701 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
| T5702 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
| T5703 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
| T5693 |
15453-15468 |
Phosphorylation |
denotes |
phosphorylation |
| T5694 |
15453-15468 |
Phosphorylation |
denotes |
phosphorylation |
| T5704 |
15473-15492 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5705 |
15473-15492 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5706 |
15473-15492 |
Positive_regulation |
denotes |
proteasome-mediated |
| T5695 |
15493-15504 |
Protein_catabolism |
denotes |
degradation |
| T5696 |
15493-15504 |
Protein_catabolism |
denotes |
degradation |
| T5697 |
15493-15504 |
Protein_catabolism |
denotes |
degradation |
| T5688 |
15512-15517 |
Protein |
denotes |
NF-κB |
| T5689 |
15528-15532 |
Protein |
denotes |
IκBα |
| T5707 |
15536-15543 |
Localization |
denotes |
release |
| T5690 |
15548-15575 |
Protein |
denotes |
NF-κB transcription factors |
| T5698 |
15585-15592 |
Entity |
denotes |
nucleus |
| T5716 |
15790-15799 |
Negative_regulation |
denotes |
exhibited |
| T5717 |
15790-15799 |
Negative_regulation |
denotes |
exhibited |
| T5711 |
15808-15814 |
Positive_regulation |
denotes |
levels |
| T5712 |
15808-15814 |
Positive_regulation |
denotes |
levels |
| T5718 |
15808-15814 |
Positive_regulation |
denotes |
levels |
| T5719 |
15808-15814 |
Positive_regulation |
denotes |
levels |
| T5720 |
15808-15814 |
Positive_regulation |
denotes |
levels |
| T5708 |
15818-15822 |
Protein |
denotes |
TBK1 |
| T5709 |
15824-15830 |
Protein |
denotes |
ERK1/2 |
| T5710 |
15836-15839 |
Protein |
denotes |
p38 |
| T5713 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
| T5714 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
| T5715 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
| T5727 |
15919-15926 |
Negative_regulation |
denotes |
absence |
| T5721 |
15941-15961 |
Protein |
denotes |
SHARPIN decreased NF |
| T5722 |
15962-15964 |
Protein |
denotes |
κB |
| T5728 |
15965-15975 |
Positive_regulation |
denotes |
activation |
| T5729 |
15988-15994 |
Regulation |
denotes |
affect |
| T5730 |
15988-15994 |
Regulation |
denotes |
affect |
| T5731 |
15988-15994 |
Regulation |
denotes |
affect |
| T5723 |
15995-15999 |
Protein |
denotes |
TBK1 |
| T5724 |
16000-16004 |
Protein |
denotes |
IRF3 |
| T5725 |
16006-16010 |
Protein |
denotes |
ERK1 |
| T5726 |
16018-16021 |
Protein |
denotes |
p38 |
| T15304 |
16085-16095 |
Negative_regulation |
denotes |
Inhibition |
| T15303 |
16099-16104 |
Protein |
denotes |
NF-κB |
| T15305 |
16386-16391 |
Protein |
denotes |
NF-κB |
| T15306 |
16393-16397 |
Protein |
denotes |
TBK1 |
| T15307 |
16398-16402 |
Protein |
denotes |
IRF3 |
| T15308 |
16404-16408 |
Protein |
denotes |
ERK1 |
| T15309 |
16416-16419 |
Protein |
denotes |
p38 |
| T15310 |
16440-16444 |
Protein |
denotes |
Beta |
| T15311 |
16445-16450 |
Protein |
denotes |
actin |
| T15315 |
16493-16499 |
Gene_expression |
denotes |
levels |
| T15312 |
16516-16522 |
Protein |
denotes |
p-IκBα |
| T15313 |
16581-16587 |
Protein |
denotes |
ImageJ |
| T15314 |
16589-16592 |
Protein |
denotes |
NIH |
| T6556 |
16747-16756 |
Negative_regulation |
denotes |
defective |
| T6553 |
16757-16761 |
Protein |
denotes |
IL12 |
| T6555 |
16762-16772 |
Gene_expression |
denotes |
production |
| T6554 |
16862-16869 |
Protein |
denotes |
SHARPIN |
| T6557 |
16988-16992 |
Protein |
denotes |
CD4+ |
| T6558 |
17006-17013 |
Protein |
denotes |
WT BMDC |
| T6559 |
17108-17112 |
Protein |
denotes |
IFNγ |
| T6560 |
17219-17222 |
Protein |
denotes |
Th1 |
| T6561 |
17294-17313 |
Protein |
denotes |
TLR2 ligand Pam3CYS |
| T6564 |
17350-17356 |
Positive_regulation |
denotes |
induce |
| T6565 |
17350-17356 |
Positive_regulation |
denotes |
induce |
| T6562 |
17362-17365 |
Protein |
denotes |
Th1 |
| T6563 |
17370-17373 |
Protein |
denotes |
Th2 |
| T6566 |
17411-17418 |
Protein |
denotes |
WT BMDC |
| T6569 |
17419-17426 |
Positive_regulation |
denotes |
induced |
| T6567 |
17427-17438 |
Protein |
denotes |
robust IFNγ |
| T6568 |
17439-17449 |
Gene_expression |
denotes |
production |
| T6573 |
17512-17519 |
Negative_regulation |
denotes |
reduced |
| T6570 |
17520-17523 |
Protein |
denotes |
Th1 |
| T6575 |
17600-17606 |
Negative_regulation |
denotes |
report |
| T6576 |
17610-17619 |
Negative_regulation |
denotes |
decreased |
| T6571 |
17620-17624 |
Protein |
denotes |
IL12 |
| T6574 |
17625-17635 |
Gene_expression |
denotes |
production |
| T6572 |
17666-17670 |
Protein |
denotes |
TLR2 |
| T6577 |
17720-17723 |
Protein |
denotes |
IL4 |
| T6579 |
17861-17871 |
Gene_expression |
denotes |
production |
| T6578 |
17875-17903 |
Protein |
denotes |
Th17-specific cytokine IL17A |
| T6580 |
18047-18050 |
Protein |
denotes |
Th1 |
| T6586 |
18121-18130 |
Positive_regulation |
denotes |
effective |
| T6581 |
18134-18137 |
Protein |
denotes |
IL2 |
| T6584 |
18138-18148 |
Gene_expression |
denotes |
production |
| T6582 |
18216-18223 |
Protein |
denotes |
WT BMDC |
| T6585 |
18224-18231 |
Positive_regulation |
denotes |
induced |
| T6583 |
18237-18240 |
Protein |
denotes |
IL2 |
| T6587 |
18357-18361 |
Protein |
denotes |
CD4+ |
| T15733 |
18563-18567 |
Protein |
denotes |
CD4+ |
| T15734 |
18634-18653 |
Protein |
denotes |
MHC haplotype: H-2b |
| T15735 |
18832-18836 |
Protein |
denotes |
CD4+ |
| T15736 |
18887-18900 |
Protein |
denotes |
MHC haplotype |
| T15740 |
18959-18968 |
Localization |
denotes |
secretion |
| T15741 |
18959-18968 |
Localization |
denotes |
secretion |
| T15742 |
18959-18968 |
Localization |
denotes |
secretion |
| T15737 |
18972-18976 |
Protein |
denotes |
IFNγ |
| T15738 |
18978-18981 |
Protein |
denotes |
IL4 |
| T15739 |
18987-18990 |
Protein |
denotes |
IL2 |
| T9454 |
19408-19426 |
Protein |
denotes |
mouse Sharpin gene |
| T9455 |
19435-19441 |
Regulation |
denotes |
affect |
| T9456 |
19814-19819 |
Protein |
denotes |
NF-κB |
| T9457 |
19925-19928 |
Protein |
denotes |
Th2 |
| T9458 |
20029-20036 |
Protein |
denotes |
SHARPIN |
| T9459 |
20750-20754 |
Protein |
denotes |
TNFα |
| T9460 |
20837-20840 |
Protein |
denotes |
TNF |
| T9462 |
20867-20877 |
Negative_regulation |
denotes |
deficiency |
| T9461 |
20881-20888 |
Protein |
denotes |
SHARPIN |
| T9463 |
21110-21117 |
Protein |
denotes |
caspase |
| T9466 |
21208-21215 |
Localization |
denotes |
release |
| T9464 |
21233-21238 |
Protein |
denotes |
DAMPs |
| T9465 |
21359-21364 |
Protein |
denotes |
HMGB1 |
| T9467 |
21365-21375 |
Binding |
denotes |
recognized |
| T9468 |
21427-21430 |
Protein |
denotes |
Th1 |
| T9469 |
21498-21501 |
Protein |
denotes |
Th1 |
| T9470 |
21618-21622 |
Protein |
denotes |
IL12 |
| T9473 |
21751-21758 |
Negative_regulation |
denotes |
reduced |
| T9471 |
21759-21766 |
Protein |
denotes |
IL12P70 |
| T9472 |
21767-21777 |
Gene_expression |
denotes |
production |
| T9476 |
21791-21801 |
Positive_regulation |
denotes |
importance |
| T9474 |
21805-21812 |
Protein |
denotes |
IL12P70 |
| T9475 |
21892-21912 |
Protein |
denotes |
IL12P35- and IL12P40 |
| T9477 |
21997-22002 |
Protein |
denotes |
NF-κB |
| T9478 |
22004-22007 |
Protein |
denotes |
TBK |
| T9479 |
22008-22012 |
Protein |
denotes |
IRF3 |
| T9480 |
22018-22022 |
Protein |
denotes |
MAPK |
| T9481 |
22161-22166 |
Protein |
denotes |
NF-κB |
| T9487 |
22167-22177 |
Positive_regulation |
denotes |
activation |
| T9488 |
22194-22203 |
Negative_regulation |
denotes |
inhibited |
| T9489 |
22274-22284 |
Positive_regulation |
denotes |
activation |
| T9490 |
22274-22284 |
Positive_regulation |
denotes |
activation |
| T9491 |
22274-22284 |
Positive_regulation |
denotes |
activation |
| T9492 |
22274-22284 |
Positive_regulation |
denotes |
activation |
| T9482 |
22288-22292 |
Protein |
denotes |
TBK1 |
| T9483 |
22293-22297 |
Protein |
denotes |
IRF3 |
| T9484 |
22299-22303 |
Protein |
denotes |
ERK1 |
| T9485 |
22310-22313 |
Protein |
denotes |
p38 |
| T9486 |
22349-22354 |
Protein |
denotes |
NF-κB |
| T9497 |
22489-22498 |
Positive_regulation |
denotes |
increased |
| T9498 |
22489-22498 |
Positive_regulation |
denotes |
increased |
| T9493 |
22509-22514 |
Protein |
denotes |
NF-κB |
| T9495 |
22515-22525 |
Positive_regulation |
denotes |
activation |
| T9499 |
22515-22525 |
Positive_regulation |
denotes |
activation |
| T9494 |
22530-22533 |
Protein |
denotes |
IL1 |
| T9496 |
22534-22547 |
Transcription |
denotes |
transcription |
| T9500 |
22730-22737 |
Protein |
denotes |
SHARPIN |
| T9501 |
22808-22813 |
Protein |
denotes |
NF-κB |
| T9504 |
22841-22851 |
Positive_regulation |
denotes |
activation |
| T9502 |
22855-22860 |
Protein |
denotes |
NF-κB |
| T9503 |
22998-23003 |
Protein |
denotes |
NF-κB |
| T9508 |
23083-23093 |
Negative_regulation |
denotes |
inhibition |
| T9505 |
23097-23102 |
Protein |
denotes |
NF-κB |
| T9507 |
23103-23113 |
Positive_regulation |
denotes |
activation |
| T9506 |
23211-23216 |
Protein |
denotes |
NF-κB |
| T9509 |
23316-23321 |
Protein |
denotes |
NF-κB |
| T9510 |
23507-23514 |
Protein |
denotes |
Sharpin |
| T9511 |
23572-23579 |
Protein |
denotes |
SHARPIN |
| T9512 |
23615-23620 |
Protein |
denotes |
NF-κB |
| T9514 |
23621-23631 |
Positive_regulation |
denotes |
activation |
| T9516 |
23621-23631 |
Positive_regulation |
denotes |
activation |
| T9513 |
23650-23657 |
Protein |
denotes |
Sharpin |
| T9515 |
23658-23668 |
Gene_expression |
denotes |
expression |
| T9517 |
23789-23803 |
Protein |
denotes |
NF-κB subunits |
| T9518 |
23864-23869 |
Protein |
denotes |
NF-κB |
| T9524 |
24029-24036 |
Gene_expression |
denotes |
produce |
| T9519 |
24037-24040 |
Protein |
denotes |
p52 |
| T9520 |
24066-24073 |
Protein |
denotes |
SHARPIN |
| T9525 |
24074-24083 |
Negative_regulation |
denotes |
deficient |
| T9521 |
24119-24124 |
Protein |
denotes |
NF-κB |
| T9522 |
24137-24140 |
Protein |
denotes |
p52 |
| T9523 |
24141-24145 |
Protein |
denotes |
RELB |
| T9526 |
24261-24268 |
Protein |
denotes |
Sharpin |
| T9527 |
24293-24298 |
Protein |
denotes |
NF-κB |
| T9530 |
24414-24420 |
Binding |
denotes |
engage |
| T9528 |
24421-24425 |
Protein |
denotes |
TLR4 |
| T9529 |
24430-24434 |
Protein |
denotes |
TLR3 |
| T9534 |
24454-24464 |
Gene_expression |
denotes |
expression |
| T9531 |
24484-24488 |
Protein |
denotes |
TLR4 |
| T9532 |
24561-24566 |
Protein |
denotes |
NF-κB |
| T9535 |
24567-24577 |
Positive_regulation |
denotes |
activation |
| T9533 |
24610-24613 |
Protein |
denotes |
TLR |
| T9536 |
24614-24624 |
Gene_expression |
denotes |
expression |
| T9542 |
24646-24653 |
Positive_regulation |
denotes |
engages |
| T9537 |
24654-24658 |
Protein |
denotes |
TLR4 |
| T9538 |
24671-24676 |
Protein |
denotes |
MYD88 |
| T9539 |
24691-24695 |
Protein |
denotes |
TRIF |
| T9540 |
24724-24728 |
Protein |
denotes |
TLR3 |
| T9541 |
24766-24770 |
Protein |
denotes |
TRIF |
| T9543 |
24811-24816 |
Protein |
denotes |
NF-κB |
| T9547 |
24817-24827 |
Positive_regulation |
denotes |
activation |
| T9544 |
24862-24869 |
Protein |
denotes |
Sharpin |
| T9548 |
24879-24889 |
Binding |
denotes |
interferes |
| T9549 |
24879-24889 |
Binding |
denotes |
interferes |
| T9550 |
24879-24889 |
Binding |
denotes |
interferes |
| T9545 |
24970-24974 |
Protein |
denotes |
RIP1 |
| T9546 |
24979-24984 |
Protein |
denotes |
TRAF6 |
| T9551 |
25024-25031 |
Protein |
denotes |
SHARPIN |
| T9559 |
25032-25041 |
Binding |
denotes |
interacts |
| T9552 |
25089-25098 |
Protein |
denotes |
ubiquitin |
| T9553 |
25099-25104 |
Protein |
denotes |
chain |
| T9554 |
25105-25111 |
Protein |
denotes |
ligase |
| T9555 |
25124-25129 |
Protein |
denotes |
NF-κB |
| T9556 |
25148-25152 |
Protein |
denotes |
RIP1 |
| T9557 |
25196-25214 |
Protein |
denotes |
TNFα-stimulated NF |
| T9558 |
25215-25217 |
Protein |
denotes |
κB |
| T9560 |
25218-25228 |
Positive_regulation |
denotes |
activation |
| T9561 |
25218-25228 |
Positive_regulation |
denotes |
activation |
| T9562 |
25234-25241 |
Protein |
denotes |
Sharpin |
| T9563 |
25310-25314 |
Protein |
denotes |
TNFα |
| T9564 |
25323-25328 |
Protein |
denotes |
NF-κB |
| T9565 |
25354-25358 |
Protein |
denotes |
TNFR |
| T9566 |
25363-25366 |
Protein |
denotes |
TLR |
| T9570 |
25449-25459 |
Regulation |
denotes |
regulation |
| T9567 |
25478-25485 |
Protein |
denotes |
SHARPIN |
| T9568 |
25515-25520 |
Protein |
denotes |
NF-κB |
| T9569 |
25521-25531 |
Positive_regulation |
denotes |
activation |
| T9571 |
25599-25606 |
Protein |
denotes |
SHARPIN |
| T9573 |
25614-25624 |
Gene_expression |
denotes |
production |
| T9572 |
25671-25676 |
Protein |
denotes |
NF-κB |
| T9574 |
25701-25704 |
Protein |
denotes |
Th1 |
| T9575 |
25728-25735 |
Protein |
denotes |
Sharpin |
| T9576 |
25736-25745 |
Negative_regulation |
denotes |
deficient |
| T9937 |
26642-26644 |
Protein |
denotes |
WT |
| T9938 |
26835-26842 |
Protein |
denotes |
Sharpin |
| T10323 |
27233-27240 |
Protein |
denotes |
Sharpin |
| T10324 |
27356-27367 |
Protein |
denotes |
CCG CCC GCC |
| T10325 |
27368-27375 |
Protein |
denotes |
GGC GGT |
| T10326 |
27390-27401 |
Protein |
denotes |
AAG CTT CTA |
| T10327 |
27402-27427 |
Protein |
denotes |
GGT GGA AGC TGC AGC AAG A |
| T10328 |
27433-27445 |
Protein |
denotes |
Sharpin cDNA |
| T10330 |
27546-27553 |
Gene_expression |
denotes |
express |
| T10329 |
27554-27581 |
Protein |
denotes |
recombinant SHARPIN protein |
| T10331 |
27891-27895 |
Protein |
denotes |
FLAG |
| T10332 |
27896-27903 |
Protein |
denotes |
SHARPIN |
| T10333 |
27904-27914 |
Gene_expression |
denotes |
expression |
| T10334 |
27904-27914 |
Gene_expression |
denotes |
expression |
| T10925 |
28588-28593 |
Protein |
denotes |
CD11c |
| T10926 |
28595-28603 |
Protein |
denotes |
MCD11C20 |
| T10927 |
28743-28750 |
Protein |
denotes |
PE-anti |
| T10928 |
28751-28755 |
Protein |
denotes |
CD14 |
| T10929 |
28929-28938 |
Protein |
denotes |
avidin-PE |
| T10930 |
28976-28987 |
Protein |
denotes |
collagenase |
| T10931 |
29116-29121 |
Protein |
denotes |
CD11c |
| T10932 |
29123-29126 |
Protein |
denotes |
HL3 |
| T10933 |
29177-29186 |
Protein |
denotes |
FITC-anti |
| T10934 |
29187-29191 |
Protein |
denotes |
CD8α |
| T11296 |
29716-29720 |
Protein |
denotes |
CD4+ |
| T11301 |
29926-29935 |
Localization |
denotes |
secretion |
| T11302 |
29926-29935 |
Localization |
denotes |
secretion |
| T11303 |
29926-29935 |
Localization |
denotes |
secretion |
| T11304 |
29926-29935 |
Localization |
denotes |
secretion |
| T11297 |
29939-29943 |
Protein |
denotes |
IFNγ |
| T11298 |
29945-29948 |
Protein |
denotes |
IL4 |
| T11299 |
29950-29953 |
Protein |
denotes |
IL2 |
| T11300 |
29959-29964 |
Protein |
denotes |
IL17A |
| T11906 |
30419-30422 |
Protein |
denotes |
TRI |
| T11910 |
30489-30499 |
Gene_expression |
denotes |
expression |
| T11911 |
30489-30499 |
Gene_expression |
denotes |
expression |
| T11912 |
30489-30499 |
Gene_expression |
denotes |
expression |
| T11907 |
30503-30506 |
Protein |
denotes |
Il6 |
| T11908 |
30508-30515 |
Protein |
denotes |
Il12p40 |
| T11909 |
30528-30540 |
Protein |
denotes |
Sharpin mRNA |
| T11913 |
30821-30840 |
Protein |
denotes |
RNasin Ribonuclease |
| T11914 |
30856-30883 |
Protein |
denotes |
M-MLV Reverse Transcriptase |
| T11915 |
31218-31222 |
Protein |
denotes |
Actb |
| T11916 |
31224-31227 |
Protein |
denotes |
IL6 |
| T11917 |
31229-31236 |
Protein |
denotes |
IL12p40 |
| T11918 |
31238-31242 |
Protein |
denotes |
Ifnβ |
| T11919 |
31255-31262 |
Protein |
denotes |
Sharpin |
| T11920 |
31370-31377 |
Protein |
denotes |
β-actin |
| T12079 |
31599-31624 |
Protein |
denotes |
RPMI-1640 complete medium |
| T12672 |
32791-32797 |
Protein |
denotes |
p-IκBα |
| T12673 |
32807-32811 |
Protein |
denotes |
IκBα |
| T12674 |
32823-32827 |
Protein |
denotes |
TBK1 |
| T12675 |
32838-32841 |
Protein |
denotes |
p38 |
| T12676 |
32851-32854 |
Protein |
denotes |
p38 |
| T12677 |
32902-32906 |
Protein |
denotes |
Beta |
| T12678 |
32907-32912 |
Protein |
denotes |
actin |
| R11003 |
T13253 |
T13254 |
themeOf |
WT BMDC,expression |
| R11889 |
T14232 |
T14233 |
themeOf |
IL12P70,production |
| R12530 |
T14953 |
T14956 |
themeOf |
TLR4,expression |
| R12531 |
T14954 |
T14957 |
themeOf |
MD2,expression |
| R12532 |
T14955 |
T14960 |
themeOf |
IL10,secretion |
| R12533 |
T14956 |
T14958 |
themeOf |
expression,decreased |
| R12534 |
T14957 |
T14959 |
themeOf |
expression,decreased |
| R12535 |
T14960 |
T14961 |
themeOf |
secretion,decreased |
| R12536 |
T14967 |
T14968 |
themeOf |
A20,production |
| R12792 |
T15303 |
T15304 |
themeOf |
NF-κB,Inhibition |
| R12793 |
T15312 |
T15315 |
themeOf |
p-IκBα,levels |
| R13166 |
T15737 |
T15740 |
themeOf |
IFNγ,secretion |
| R13167 |
T15738 |
T15741 |
themeOf |
IL4,secretion |
| R13168 |
T15739 |
T15742 |
themeOf |
IL2,secretion |
| R1773 |
T2135 |
T2136 |
themeOf |
SHARPIN,expressed |
| R1776 |
T2138 |
T2140 |
themeOf |
IFNγ [5],secretion |
| R1778 |
T2140 |
T2141 |
themeOf |
secretion,decreased |
| R1779 |
T2144 |
T2145 |
themeOf |
IL5,deficient |
| R1780 |
T2149 |
T2151 |
themeOf |
SHARPIN,deficient |
| R1781 |
T2153 |
T2154 |
themeOf |
SHARPIN,deficient |
| R1782 |
T2155 |
T2157 |
themeOf |
SHARPIN protein,lack |
| R1783 |
T2156 |
T2158 |
themeOf |
NF-κB,activation |
| R1784 |
T2157 |
T2159 |
causeOf |
lack,impaired |
| R1785 |
T2158 |
T2159 |
themeOf |
activation,impaired |
| R1786 |
T2160 |
T2161 |
themeOf |
Th1,production |
| R1787 |
T2161 |
T2162 |
themeOf |
production,stimulate |
| R1788 |
T2164 |
T2165 |
themeOf |
SHARPIN,deficient |
| R2284 |
T2772 |
T2776 |
partOf |
SHARPIN,domain |
| R2285 |
T2774 |
T2776 |
partOf |
zinc-finger Ran-binding protein 2,domain |
| R2286 |
T2775 |
T2776 |
partOf |
ZFRBP,domain |
| R2287 |
T2777 |
T2779 |
themeOf |
SHARPIN protein,present |
| R2288 |
T2781 |
T2782 |
themeOf |
Sharpin,expression |
| R2289 |
T2783 |
T2784 |
themeOf |
Sharpin mRNA,decreased |
| R2290 |
T2785 |
T2786 |
themeOf |
Sharpin mRNA,reduction |
| R2291 |
T2787 |
T2790 |
themeOf |
Sharpin,Transfection |
| R2292 |
T2788 |
T2793 |
themeOf |
SHARPIN protein,localization |
| R2293 |
T2789 |
T2794 |
themeOf |
Fig. 1E,localization |
| R2294 |
T2790 |
T2791 |
themeOf |
Transfection,Transfection |
| R2295 |
T2792 |
T2793 |
locationOf |
cytoplasmic,localization |
| R2296 |
T2792 |
T2794 |
locationOf |
cytoplasmic,localization |
| R3530 |
T4265 |
T4270 |
themeOf |
IL6,secretion |
| R3531 |
T4266 |
T4271 |
themeOf |
IL12P70,secretion |
| R3532 |
T4267 |
T4272 |
themeOf |
GMCSF,secretion |
| R3533 |
T4268 |
T4273 |
themeOf |
WT BMDC,produced |
| R3534 |
T4269 |
T4274 |
themeOf |
Fig,produced |
| R3535 |
T4270 |
T4275 |
themeOf |
secretion,resulted |
| R3536 |
T4271 |
T4276 |
themeOf |
secretion,resulted |
| R3537 |
T4272 |
T4277 |
themeOf |
secretion,resulted |
| R3538 |
T4278 |
T4279 |
themeOf |
Sharpin,deficient |
| R3539 |
T4281 |
T4284 |
themeOf |
IL12P70,secreted |
| R3540 |
T4282 |
T4286 |
causeOf |
SHARPIN,role |
| R3541 |
T4283 |
T4285 |
themeOf |
IL12P70,production |
| R3542 |
T4285 |
T4286 |
themeOf |
production,role |
| R3543 |
T4287 |
T4289 |
themeOf |
cytokines Il6,levels |
| R3544 |
T4288 |
T4290 |
themeOf |
Il12p40,levels |
| R3545 |
T4289 |
T4291 |
themeOf |
levels,reduced |
| R3546 |
T4290 |
T4292 |
themeOf |
levels,reduced |
| R4542 |
T5634 |
T5635 |
themeOf |
TLR,expression |
| R4543 |
T5635 |
T5636 |
themeOf |
expression,increased |
| R4544 |
T5637 |
T5643 |
themeOf |
LPS receptor,expression |
| R4545 |
T5638 |
T5644 |
themeOf |
TLR4,expression |
| R4546 |
T5645 |
T5648 |
themeOf |
CD14,expression |
| R4547 |
T5646 |
T5649 |
themeOf |
TLR4,expression |
| R4548 |
T5647 |
T5650 |
themeOf |
MD2,expression |
| R4549 |
T5651 |
T5653 |
themeOf |
cytokines IL10,secretion |
| R4550 |
T5651 |
T5655 |
causeOf |
cytokines IL10,inhibit |
| R4551 |
T5652 |
T5654 |
themeOf |
IL12,secretion |
| R4552 |
T5654 |
T5655 |
themeOf |
secretion,inhibit |
| R4553 |
T5656 |
T5659 |
themeOf |
IL10,stimulated |
| R4554 |
T5657 |
T5661 |
causeOf |
IL10,responsible |
| R4555 |
T5658 |
T5660 |
themeOf |
IL12P70,secretion |
| R4556 |
T5660 |
T5661 |
themeOf |
secretion,responsible |
| R4557 |
T5660 |
T5662 |
themeOf |
secretion,decreased |
| R4558 |
T5663 |
T5664 |
themeOf |
TLR,expression |
| R4559 |
T5664 |
T5665 |
themeOf |
expression,Increased |
| R4560 |
T5667 |
T5668 |
themeOf |
A20,overexpression |
| R4561 |
T5668 |
T5669 |
themeOf |
overexpression,overexpression |
| R4562 |
T5668 |
T5670 |
themeOf |
overexpression,ruling |
| R4563 |
T5669 |
T5671 |
themeOf |
overexpression,ruling |
| R4564 |
T5673 |
T5676 |
themeOf |
NF-κB,regulated |
| R4565 |
T5674 |
T5677 |
themeOf |
TBK1,regulated |
| R4566 |
T5675 |
T5678 |
themeOf |
IRF3,regulated |
| R4567 |
T5683 |
T5684 |
themeOf |
Sharpin,deficient |
| R4568 |
T5685 |
T5691 |
themeOf |
IκB kinase,phosphorylation |
| R4569 |
T5686 |
T5692 |
themeOf |
IKK1/2,phosphorylation |
| R4570 |
T5686 |
T5695 |
themeOf |
IKK1/2,degradation |
| R4571 |
T5688 |
T5693 |
themeOf |
NF-κB,phosphorylation |
| R4572 |
T5688 |
T5696 |
themeOf |
NF-κB,degradation |
| R4573 |
T5689 |
T5694 |
themeOf |
IκBα,phosphorylation |
| R4574 |
T5689 |
T5697 |
themeOf |
IκBα,degradation |
| R4575 |
T5690 |
T5707 |
themeOf |
NF-κB transcription factors,release |
| R4576 |
T5691 |
T5699 |
themeOf |
phosphorylation,Stimulus-induced |
| R4577 |
T5692 |
T5700 |
themeOf |
phosphorylation,Stimulus-induced |
| R4578 |
T5695 |
T5701 |
themeOf |
degradation,allowing |
| R4579 |
T5695 |
T5704 |
themeOf |
degradation,proteasome-mediated |
| R4580 |
T5696 |
T5702 |
themeOf |
degradation,allowing |
| R4581 |
T5696 |
T5705 |
themeOf |
degradation,proteasome-mediated |
| R4582 |
T5697 |
T5703 |
themeOf |
degradation,allowing |
| R4583 |
T5697 |
T5706 |
themeOf |
degradation,proteasome-mediated |
| R4584 |
T5698 |
T5707 |
locationOf |
nucleus,release |
| R4585 |
T5708 |
T5711 |
themeOf |
TBK1,levels |
| R4586 |
T5708 |
T5713 |
themeOf |
TBK1,phosphorylation |
| R4587 |
T5709 |
T5712 |
themeOf |
ERK1/2,levels |
| R4588 |
T5709 |
T5714 |
themeOf |
ERK1/2,phosphorylation |
| R4589 |
T5710 |
T5715 |
themeOf |
p38,phosphorylation |
| R4590 |
T5711 |
T5716 |
themeOf |
levels,exhibited |
| R4591 |
T5712 |
T5717 |
themeOf |
levels,exhibited |
| R4592 |
T5713 |
T5718 |
themeOf |
phosphorylation,levels |
| R4593 |
T5714 |
T5719 |
themeOf |
phosphorylation,levels |
| R4594 |
T5715 |
T5720 |
themeOf |
phosphorylation,levels |
| R4595 |
T5721 |
T5727 |
themeOf |
SHARPIN decreased NF,absence |
| R4596 |
T5722 |
T5728 |
themeOf |
κB,activation |
| R4597 |
T5723 |
T5729 |
themeOf |
TBK1,affect |
| R4598 |
T5724 |
T5730 |
themeOf |
IRF3,affect |
| R4599 |
T5725 |
T5731 |
themeOf |
ERK1,affect |
| R4600 |
T5727 |
T5729 |
causeOf |
absence,affect |
| R4601 |
T5727 |
T5730 |
causeOf |
absence,affect |
| R4602 |
T5727 |
T5731 |
causeOf |
absence,affect |
| R5313 |
T6553 |
T6555 |
themeOf |
IL12,production |
| R5314 |
T6555 |
T6556 |
themeOf |
production,defective |
| R5315 |
T6562 |
T6564 |
themeOf |
Th1,induce |
| R5316 |
T6563 |
T6565 |
themeOf |
Th2,induce |
| R5317 |
T6566 |
T6569 |
causeOf |
WT BMDC,induced |
| R5318 |
T6567 |
T6568 |
themeOf |
robust IFNγ,production |
| R5319 |
T6568 |
T6569 |
themeOf |
production,induced |
| R5320 |
T6570 |
T6573 |
themeOf |
Th1,reduced |
| R5321 |
T6571 |
T6574 |
themeOf |
IL12,production |
| R5322 |
T6574 |
T6575 |
themeOf |
production,report |
| R5323 |
T6574 |
T6576 |
themeOf |
production,decreased |
| R5324 |
T6578 |
T6579 |
themeOf |
Th17-specific cytokine IL17A,production |
| R5325 |
T6581 |
T6584 |
themeOf |
IL2,production |
| R5326 |
T6582 |
T6585 |
causeOf |
WT BMDC,induced |
| R5327 |
T6583 |
T6585 |
themeOf |
IL2,induced |
| R5328 |
T6584 |
T6586 |
themeOf |
production,effective |
| R630 |
T840 |
T847 |
themeOf |
Sharpin,mutations |
| R631 |
T841 |
T851 |
themeOf |
SHANK,associated |
| R632 |
T842 |
T848 |
themeOf |
RH,mutations |
| R633 |
T842 |
T852 |
themeOf |
RH,associated |
| R634 |
T843 |
T849 |
themeOf |
Rbckl1,mutations |
| R635 |
T843 |
T853 |
themeOf |
Rbckl1,associated |
| R636 |
T844 |
T850 |
themeOf |
Sipl1,mutations |
| R637 |
T844 |
T854 |
themeOf |
Sipl1,associated |
| R638 |
T845 |
T855 |
themeOf |
T helper1,secretion |
| R639 |
T846 |
T856 |
themeOf |
Th1,secretion |
| R640 |
T855 |
T857 |
themeOf |
secretion,dysregulated |
| R641 |
T856 |
T858 |
themeOf |
secretion,dysregulated |
| R642 |
T859 |
T860 |
themeOf |
SHARPIN,deficient |
| R643 |
T861 |
T862 |
themeOf |
SHARPIN,deficiency |
| R644 |
T865 |
T868 |
themeOf |
CD40,expression |
| R645 |
T866 |
T869 |
themeOf |
CD80,expression |
| R646 |
T867 |
T870 |
themeOf |
CD86,expression |
| R647 |
T868 |
T871 |
themeOf |
expression,increases |
| R648 |
T869 |
T872 |
themeOf |
expression,increases |
| R649 |
T870 |
T873 |
themeOf |
expression,increases |
| R650 |
T874 |
T878 |
themeOf |
SHARPIN,deficient |
| R651 |
T875 |
T879 |
themeOf |
IL6,transcription |
| R652 |
T875 |
T882 |
themeOf |
IL6,secretion |
| R653 |
T876 |
T880 |
themeOf |
IL12P70,transcription |
| R654 |
T876 |
T883 |
themeOf |
IL12P70,secretion |
| R655 |
T877 |
T881 |
themeOf |
GMCSF,transcription |
| R656 |
T877 |
T884 |
themeOf |
GMCSF,secretion |
| R657 |
T879 |
T885 |
themeOf |
transcription,reduced |
| R658 |
T880 |
T886 |
themeOf |
transcription,reduced |
| R659 |
T881 |
T887 |
themeOf |
transcription,reduced |
| R660 |
T888 |
T893 |
themeOf |
NF-κB,activation |
| R661 |
T895 |
T896 |
themeOf |
Sharpin,loss |
| R7796 |
T9454 |
T9455 |
themeOf |
mouse Sharpin gene,affect |
| R7798 |
T9543 |
T9547 |
themeOf |
NF-κB,activation |
| R7799 |
T9544 |
T9548 |
themeOf |
Sharpin,interferes |
| R7800 |
T9544 |
T9549 |
themeOf |
Sharpin,interferes |
| R7801 |
T9544 |
T9550 |
themeOf |
Sharpin,interferes |
| R7802 |
T9545 |
T9549 |
themeOf |
RIP1,interferes |
| R7803 |
T9546 |
T9550 |
themeOf |
TRAF6,interferes |
| R7804 |
T9551 |
T9559 |
themeOf |
SHARPIN,interacts |
| R7805 |
T9461 |
T9462 |
themeOf |
SHARPIN,deficiency |
| R7806 |
T9464 |
T9466 |
themeOf |
DAMPs,release |
| R7807 |
T9465 |
T9467 |
themeOf |
HMGB1,recognized |
| R7808 |
T9557 |
T9560 |
themeOf |
TNFα-stimulated NF,activation |
| R7809 |
T9471 |
T9472 |
themeOf |
IL12P70,production |
| R7810 |
T9472 |
T9473 |
themeOf |
production,reduced |
| R7811 |
T9474 |
T9476 |
themeOf |
IL12P70,importance |
| R7812 |
T9558 |
T9561 |
themeOf |
κB,activation |
| R7813 |
T9568 |
T9569 |
themeOf |
NF-κB,activation |
| R7814 |
T9481 |
T9487 |
themeOf |
NF-κB,activation |
| R7815 |
T9482 |
T9489 |
themeOf |
TBK1,activation |
| R7816 |
T9483 |
T9490 |
themeOf |
IRF3,activation |
| R7817 |
T9484 |
T9491 |
themeOf |
ERK1,activation |
| R7818 |
T9485 |
T9492 |
themeOf |
p38,activation |
| R7819 |
T9487 |
T9488 |
themeOf |
activation,inhibited |
| R7820 |
T9493 |
T9495 |
themeOf |
NF-κB,activation |
| R7821 |
T9494 |
T9496 |
themeOf |
IL1,transcription |
| R7822 |
T9569 |
T9570 |
themeOf |
activation,regulation |
| R7823 |
T9495 |
T9497 |
themeOf |
activation,increased |
| R7824 |
T9496 |
T9498 |
themeOf |
transcription,increased |
| R7825 |
T9496 |
T9499 |
themeOf |
transcription,activation |
| R7826 |
T9571 |
T9573 |
themeOf |
SHARPIN,production |
| R7827 |
T9575 |
T9576 |
themeOf |
Sharpin,deficient |
| R7828 |
T9502 |
T9504 |
themeOf |
NF-κB,activation |
| R7829 |
T9505 |
T9507 |
themeOf |
NF-κB,activation |
| R7830 |
T9507 |
T9508 |
themeOf |
activation,inhibition |
| R7831 |
T9512 |
T9514 |
themeOf |
NF-κB,activation |
| R7832 |
T9513 |
T9515 |
themeOf |
Sharpin,expression |
| R7833 |
T9515 |
T9516 |
themeOf |
expression,activation |
| R7834 |
T9519 |
T9524 |
themeOf |
p52,produce |
| R7835 |
T9520 |
T9525 |
themeOf |
SHARPIN,deficient |
| R7836 |
T9529 |
T9530 |
themeOf |
TLR3,engage |
| R7837 |
T9531 |
T9534 |
themeOf |
TLR4,expression |
| R7838 |
T9532 |
T9535 |
themeOf |
NF-κB,activation |
| R7839 |
T9533 |
T9536 |
themeOf |
TLR,expression |
| R7840 |
T9537 |
T9542 |
themeOf |
TLR4,engages |
| R8507 |
T10329 |
T10330 |
themeOf |
recombinant SHARPIN protein,express |
| R8508 |
T10331 |
T10333 |
themeOf |
FLAG,expression |
| R8509 |
T10332 |
T10334 |
themeOf |
SHARPIN,expression |
| R9380 |
T11297 |
T11301 |
themeOf |
IFNγ,secretion |
| R9381 |
T11298 |
T11302 |
themeOf |
IL4,secretion |
| R9382 |
T11299 |
T11303 |
themeOf |
IL2,secretion |
| R9383 |
T11300 |
T11304 |
themeOf |
IL17A,secretion |
| R9881 |
T11907 |
T11910 |
themeOf |
Il6,expression |
| R9882 |
T11908 |
T11911 |
themeOf |
Il12p40,expression |
| R9883 |
T11909 |
T11912 |
themeOf |
Sharpin mRNA,expression |
