bionlp-ost-19-BB-rel-train  

BB-rel@ldeleger:BB-rel-21917915 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-92 Title denotes Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH.
T3 43-64 Microorganism denotes Staphylococcus aureus
T4 93-102 Phenotype denotes Pathogens
T2 93-1013 Paragraph denotes Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to access this source. Here, we show how one of the commonest and most significant human pathogens, Staphylococcus aureus, captures Hb as the first step of an iron-scavenging pathway. The x-ray crystal structure of Hb bound to a domain from the Isd (iron-regulated surface determinant) protein, IsdH, is the first structure of a Hb capture complex to be determined. Surface mutations in Hb that reduce binding to the Hb-receptor limit the capacity of S. aureus to utilize Hb as an iron source, suggesting that Hb sequence is a factor in host susceptibility to infection. The demonstration that pathogens make highly specific recognition complexes with Hb raises the possibility of developing inhibitors of Hb binding as antibacterial agents.
T5 163-170 Habitat denotes mammals
T6 234-243 Phenotype denotes pathogens
T8 355-360 Habitat denotes human
T7 355-370 Phenotype denotes human pathogens
T9 372-393 Microorganism denotes Staphylococcus aureus
E1 372-393 Lives_In denotes Staphylococcus aureus
E2 372-393 Exhibits denotes Staphylococcus aureus
T10 723-732 Microorganism denotes S. aureus
T11 866-875 Phenotype denotes pathogens
R1 E1 T9 Microorganism Staphylococcus aureus,Staphylococcus aureus
R2 E1 T8 Location Staphylococcus aureus,human
R3 E2 T9 Microorganism Staphylococcus aureus,Staphylococcus aureus
R4 E2 T7 Property Staphylococcus aureus,human pathogens