bionlp-ost-19-BB-rel-test  

BB-rel@ldeleger:BB-rel-24261996 JSONTXT

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Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1 0-126 Title denotes Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism.
T7 11-31 Microorganism denotes Bordetella pertussis
T8 32-39 Habitat denotes vaccine
T9 57-68 Habitat denotes respiratory
T10 57-84 Microorganism denotes respiratory syncytial virus
T2 127-420 Paragraph denotes We attenuated virulent Bordetella pertussis by genetically eliminating or detoxifying three major toxins. This strain, named BPZE1, is being developed as a possible live nasal vaccine for the prevention of whooping cough. It is immunogenic and safe when given intranasally in adult volunteers.
T11 141-149 Phenotype denotes virulent
T12 150-170 Microorganism denotes Bordetella pertussis
T13 252-257 Microorganism denotes BPZE1
T14 292-310 Habitat denotes live nasal vaccine
T15 297-302 Habitat denotes nasal
T16 403-419 Habitat denotes adult volunteers
T3 421-596 Paragraph denotes Before testing in human infants, we wished to examine the potential effect of BPZE1 on a common pediatric infection (respiratory syncytial virus [RSV]) in a preclinical model.
T17 439-452 Habitat denotes human infants
T18 499-504 Microorganism denotes BPZE1
T19 517-526 Habitat denotes pediatric
T20 538-549 Habitat denotes respiratory
T21 538-565 Microorganism denotes respiratory syncytial virus
T22 567-570 Microorganism denotes RSV
T23 597-602 Microorganism denotes BPZE1
T4 597-780 Paragraph denotes BPZE1 was administered before or after RSV administration in adult or neonatal mice. Pathogen replication, inflammation, immune cell recruitment, and cytokine responses were measured.
T24 636-639 Microorganism denotes RSV
T25-0 658-663 _FRAGMENT denotes adult
T26 667-680 Habitat denotes neonatal mice
T25-1 676-680 Habitat denotes mice
T27 682-690 Phenotype denotes Pathogen
T28 718-729 Habitat denotes immune cell
T29 781-786 Microorganism denotes BPZE1
T5 781-1452 Paragraph denotes BPZE1 alone did not cause overt disease, but induced efflux of neutrophils into the airway lumen and production of IL-10 and IL-17 by mucosal CD4(+) T cells. Given intranasally before RSV infection, BPZE1 markedly attenuated RSV, preventing weight loss, reducing viral load, and attenuating lung cell recruitment. Given neonatally, BPZE1 also protected against RSV-induced weight loss even through to adulthood. Furthermore, it markedly increased IL-17 production by CD4(+) T cells and natural killer cells and recruited regulatory cells and neutrophils after virus challenge. Administration of anti-IL-17 antibodies ablated the protective effect of BPZE1 on RSV disease.
T30 844-855 Habitat denotes neutrophils
T31 865-871 Habitat denotes airway
T32 865-877 Habitat denotes airway lumen
T34 915-922 Habitat denotes mucosal
T33 915-937 Habitat denotes mucosal CD4(+) T cells
T35 965-968 Microorganism denotes RSV
T36 980-985 Microorganism denotes BPZE1
T37 1006-1009 Microorganism denotes RSV
T39 1072-1076 Habitat denotes lung
T38 1072-1081 Habitat denotes lung cell
T40 1113-1118 Microorganism denotes BPZE1
T41 1142-1145 Microorganism denotes RSV
T42 1248-1262 Habitat denotes CD4(+) T cells
T43 1267-1287 Habitat denotes natural killer cells
T44 1302-1318 Habitat denotes regulatory cells
T45 1323-1334 Habitat denotes neutrophils
T46 1431-1436 Microorganism denotes BPZE1
T47 1440-1443 Microorganism denotes RSV
T6 1453-1752 Paragraph denotes Rather than enhancing RSV disease, BPZE1 protected against viral infection, modified viral responses, and enhanced natural mucosal resistance. Prevention of RSV infection by BPZE1 seems in part to be caused by induction of IL-17. Clinical trial registered with www.clinicaltrials.gov (NCT 01188512).
T48 1475-1478 Microorganism denotes RSV
T49 1488-1493 Microorganism denotes BPZE1
T50 1576-1583 Habitat denotes mucosal
T51 1610-1613 Microorganism denotes RSV
T52 1627-1632 Microorganism denotes BPZE1
C-T25-0 T25-1 T25-0 _lexicallyChainedTo mice,adult