BB-rel@ldeleger:BB-rel-19339076 JSONTXT

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Id Subject Object Predicate Lexical cue
T4 0-4 Habitat denotes Bile
T3 0-15 Phenotype denotes Bile resistance
T1 0-132 Title denotes Bile resistance in Lactococcus lactis strains varies with cellular fatty acid composition: analysis by using different growth media.
T5 19-37 Microorganism denotes Lactococcus lactis
T7 133-137 Habitat denotes Bile
T6 133-148 Phenotype denotes Bile resistance
T2 133-2382 Paragraph denotes Bile resistance is one of the basic characteristics of probiotic bacteria. The aim of this study was to investigate the characteristics of bile resistance in lactococci by studying the relationship between bile resistance and cellular fatty acid composition in lactococcci grown on different media. We determined the bile resistance of 14 strains in lactose-free M17 medium supplemented with either glucose only (GM17) or lactose only (LM17). Gas chromatographic analyses of free lipids extracted from the tested strains were used for determining their fatty acid composition. A correlation analysis of all strains grown in both media revealed significant positive correlations between bile resistance and relative contents of hexadecanoic acid and octadecenoic acid, and negative correlations between bile resistance and relative contents of hexadecenoic acid and C-19 cyclopropane fatty acid. It is also a fact that the fatty acids associated with bile resistance depended on species, strain, and/or growth medium. In L. lactis subsp. cremoris strains grown in GM17 medium, the bile-resistant strains had significantly more octadecenoic acid than the bile-sensitive strains. In LM17 medium, bile-resistant strains had significantly more octadecenoic acid and significantly less C-19 cyclopropane fatty acid than the bile-sensitive strains. In L. lactis subsp. lactis strains, bile resistances of some of the tested strains were altered by growth medium. Some strains were resistant to bile in GM17 medium but sensitive to bile in LM17 medium. Some strains were resistant in both media tested. The strains grown in GM17 medium had significantly more hexadecanoic acid and octadecenoic acid, and significantly less tetradecanoic acid, octadecadienoic acid and C-19 cyclopropane fatty acid than the strains grown in LM17 medium. In conclusion, the fatty acid compositions of the bile-resistant lactococci differed from those of the bile-sensitive ones. More importantly, our data suggest that altering their fatty acid composition (i.e. increased hexadecanoic acid and octadecenoic acid and decreased hexadecenoic acid and C-19 cyclopropane fatty acid) by changing growth conditions may be a useful way to enhance their bile resistance in lactococci.
T8 188-197 Phenotype denotes probiotic
T10 272-276 Habitat denotes bile
T9 272-287 Phenotype denotes bile resistance
T11 291-301 Microorganism denotes lactococci
T13 339-343 Habitat denotes bile
T12 339-354 Phenotype denotes bile resistance
T14 394-405 Microorganism denotes lactococcci
T16 450-454 Habitat denotes bile
T15 450-465 Phenotype denotes bile resistance
T17-0 483-524 _FRAGMENT denotes lactose-free M17 medium supplemented with
T18-0 483-524 _FRAGMENT denotes lactose-free M17 medium supplemented with
T17-1 532-551 Habitat denotes glucose only (GM17)
T18-1 555-574 Habitat denotes lactose only (LM17)
T20 819-823 Habitat denotes bile
T19 819-834 Phenotype denotes bile resistance
T22 935-939 Habitat denotes bile
T21 935-950 Phenotype denotes bile resistance
T24 1083-1087 Habitat denotes bile
T23 1083-1098 Phenotype denotes bile resistance
T25 1153-1178 Microorganism denotes L. lactis subsp. cremoris
E5 1153-1178 Lives_In denotes L. lactis subsp. cremoris
E6 1153-1178 Lives_In denotes L. lactis subsp. cremoris
E1 1153-1178 Exhibits denotes L. lactis subsp. cremoris
E2 1153-1178 Exhibits denotes L. lactis subsp. cremoris
E3 1153-1178 Exhibits denotes L. lactis subsp. cremoris
E4 1153-1178 Exhibits denotes L. lactis subsp. cremoris
T26 1196-1207 Habitat denotes GM17 medium
T28 1213-1217 Habitat denotes bile
T27 1213-1227 Phenotype denotes bile-resistant
T30 1286-1290 Habitat denotes bile
T29 1286-1300 Phenotype denotes bile-sensitive
T31 1313-1324 Habitat denotes LM17 medium
T33 1326-1330 Habitat denotes bile
T32 1326-1340 Phenotype denotes bile-resistant
T35 1451-1455 Habitat denotes bile
T34 1451-1465 Phenotype denotes bile-sensitive
T36 1478-1501 Microorganism denotes L. lactis subsp. lactis
E11 1478-1501 Lives_In denotes L. lactis subsp. lactis
E12 1478-1501 Lives_In denotes L. lactis subsp. lactis
E7 1478-1501 Exhibits denotes L. lactis subsp. lactis
E8 1478-1501 Exhibits denotes L. lactis subsp. lactis
E9 1478-1501 Exhibits denotes L. lactis subsp. lactis
E10 1478-1501 Exhibits denotes L. lactis subsp. lactis
T38 1511-1515 Habitat denotes bile
T37 1511-1527 Phenotype denotes bile resistances
T39 1607-1624 Phenotype denotes resistant to bile
T40 1620-1624 Habitat denotes bile
T41 1628-1639 Habitat denotes GM17 medium
T42 1644-1661 Phenotype denotes sensitive to bile
T43 1657-1661 Habitat denotes bile
T44 1665-1676 Habitat denotes LM17 medium
T45 1696-1705 Phenotype denotes resistant
T46 1749-1760 Habitat denotes GM17 medium
T47 1948-1959 Habitat denotes LM17 medium
T49 2011-2015 Habitat denotes bile
T48 2011-2025 Phenotype denotes bile-resistant
T50 2026-2036 Microorganism denotes lactococci
E13 2026-2036 Exhibits denotes lactococci
E14 2026-2036 Exhibits denotes lactococci
T52 2064-2068 Habitat denotes bile
T51 2064-2078 Phenotype denotes bile-sensitive
T54 2352-2356 Habitat denotes bile
T53 2352-2367 Phenotype denotes bile resistance
T55 2371-2381 Microorganism denotes lactococci
E15 2371-2381 Exhibits denotes lactococci
C-T17-0 T17-1 T17-0 _lexicallyChainedTo glucose only (GM17),lactose-free M17 medium supplemented with
C-T18-0 T18-1 T18-0 _lexicallyChainedTo lactose only (LM17),lactose-free M17 medium supplemented with
R1 E5 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris
R10 E3 T32 Property L. lactis subsp. cremoris,bile-resistant
R11 E4 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris
R12 E4 T29 Property L. lactis subsp. cremoris,bile-sensitive
R13 E11 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R14 E11 T41 Location L. lactis subsp. lactis,GM17 medium
R15 E12 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R16 E12 T44 Location L. lactis subsp. lactis,LM17 medium
R17 E7 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R18 E7 T42 Property L. lactis subsp. lactis,sensitive to bile
R19 E8 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R2 E5 T26 Location L. lactis subsp. cremoris,GM17 medium
R20 E8 T37 Property L. lactis subsp. lactis,bile resistances
R21 E9 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R22 E9 T45 Property L. lactis subsp. lactis,resistant
R23 E10 T36 Microorganism L. lactis subsp. lactis,L. lactis subsp. lactis
R24 E10 T39 Property L. lactis subsp. lactis,resistant to bile
R25 E13 T50 Microorganism lactococci,lactococci
R26 E13 T51 Property lactococci,bile-sensitive
R27 E14 T50 Microorganism lactococci,lactococci
R28 E14 T48 Property lactococci,bile-resistant
R29 E15 T55 Microorganism lactococci,lactococci
R3 E6 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris
R30 E15 T53 Property lactococci,bile resistance
R4 E6 T31 Location L. lactis subsp. cremoris,LM17 medium
R5 E1 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris
R6 E1 T27 Property L. lactis subsp. cremoris,bile-resistant
R7 E2 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris
R8 E2 T34 Property L. lactis subsp. cremoris,bile-sensitive
R9 E3 T25 Microorganism L. lactis subsp. cremoris,L. lactis subsp. cremoris