BB-rel@ldeleger:BB-rel-12109661 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-110 Title denotes Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan.
T3 10-29 Microorganism denotes Helicobacter pylori
E1 10-29 Lives_In denotes Helicobacter pylori
T4 86-93 Habitat denotes gastric
T5 104-109 Geographical denotes Japan
T2 111-1577 Paragraph denotes The incidence of gastric cancer and the prevalence of Helicobacter pylori are high in Japan, so it is an important issue whether long-term H. pylori infection leads to chronic atrophic gastritis, considered one of the precursors of gastric cancer. We have reported that the grade of atrophy was higher in H. pylori-positive subjects than in H. pylori-negative subjects. It has also been reported that the atrophy of gastric mucosa increased in H. pylori-infected monkeys compared with control monkeys in a 5-year follow-up study. Most H. pylori infections occur in children, and atrophy of the gastric mucosa progresses during aging. Long-term data show that H. pylori infection can lead to gastric atrophy and may play an important role in the development of gastric cancer. Interestingly, there was no difference in the prevalence of H. pylori between patients with chronic gastritis and gastric cancer in Japan, but the prevalence of H. pylori in young Japanese gastric cancer patients was significantly higher than in the control group. These data clearly show that H. pylori infection is one of the risk factors of gastric cancer in young Japanese people, There is no answer to whether curing H. pylori infection can reverse the atrophy of the gastric mucosa and decrease the risk of gastric cancer development. To clarify this issue, an intervention study must be done. A large clinical trial called the Japanese Intervention Trial of H. pylori is in progress.
T6 128-135 Habitat denotes gastric
T7 165-184 Microorganism denotes Helicobacter pylori
E2 165-184 Lives_In denotes Helicobacter pylori
T8 197-202 Geographical denotes Japan
T9 250-259 Microorganism denotes H. pylori
T10 343-350 Habitat denotes gastric
T11 416-425 Microorganism denotes H. pylori
E3 416-425 Lives_In denotes H. pylori
T12 416-443 Habitat denotes H. pylori-positive subjects
T13 452-461 Microorganism denotes H. pylori
T14 452-479 Habitat denotes H. pylori-negative subjects
T15 527-534 Habitat denotes gastric
T16 527-541 Habitat denotes gastric mucosa
T17 555-564 Microorganism denotes H. pylori
E4 555-564 Lives_In denotes H. pylori
T18 555-581 Habitat denotes H. pylori-infected monkeys
T19 596-611 Habitat denotes control monkeys
T20 646-655 Microorganism denotes H. pylori
E5 646-655 Lives_In denotes H. pylori
T21 676-684 Habitat denotes children
T23 705-712 Habitat denotes gastric
T22 705-719 Habitat denotes gastric mucosa
T24 770-779 Microorganism denotes H. pylori
T25 802-809 Habitat denotes gastric
T26 871-878 Habitat denotes gastric
T27 947-956 Microorganism denotes H. pylori
E6 947-956 Lives_In denotes H. pylori
E7 947-956 Lives_In denotes H. pylori
E8 947-956 Lives_In denotes H. pylori
T29-0 965-978 _FRAGMENT denotes patients with
T28 965-996 Habitat denotes patients with chronic gastritis
T30 1001-1008 Habitat denotes gastric
T29-1 1001-1015 Habitat denotes gastric cancer
T31 1019-1024 Geographical denotes Japan
T32 1048-1057 Microorganism denotes H. pylori
E9 1048-1057 Lives_In denotes H. pylori
T33 1061-1099 Habitat denotes young Japanese gastric cancer patients
T34 1076-1083 Habitat denotes gastric
T35 1137-1150 Habitat denotes control group
T36 1181-1190 Microorganism denotes H. pylori
E10 1181-1190 Lives_In denotes H. pylori
T37 1231-1238 Habitat denotes gastric
T38 1249-1270 Habitat denotes young Japanese people
T39 1309-1318 Microorganism denotes H. pylori
T40 1360-1367 Habitat denotes gastric
T41 1360-1374 Habitat denotes gastric mucosa
T42 1400-1407 Habitat denotes gastric
T43 1552-1561 Microorganism denotes H. pylori
C-T29-0 T29-1 T29-0 _lexicallyChainedTo gastric cancer,patients with
R1 E1 T3 Microorganism Helicobacter pylori,Helicobacter pylori
R10 E5 T21 Location H. pylori,children
R11 E6 T27 Microorganism H. pylori,H. pylori
R12 E6 T29-0 Location H. pylori,patients with
R13 E7 T27 Microorganism H. pylori,H. pylori
R14 E7 T28 Location H. pylori,patients with chronic gastritis
R15 E8 T27 Microorganism H. pylori,H. pylori
R16 E8 T31 Location H. pylori,Japan
R17 E9 T32 Microorganism H. pylori,H. pylori
R18 E9 T33 Location H. pylori,young Japanese gastric cancer patients
R19 E10 T36 Microorganism H. pylori,H. pylori
R2 E1 T5 Location Helicobacter pylori,Japan
R20 E10 T38 Location H. pylori,young Japanese people
R3 E2 T7 Microorganism Helicobacter pylori,Helicobacter pylori
R4 E2 T8 Location Helicobacter pylori,Japan
R5 E3 T11 Microorganism H. pylori,H. pylori
R6 E3 T12 Location H. pylori,H. pylori-positive subjects
R7 E4 T17 Microorganism H. pylori,H. pylori
R8 E4 T18 Location H. pylori,H. pylori-infected monkeys
R9 E5 T20 Microorganism H. pylori,H. pylori