BB-norm@ldeleger:BB-norm-21917915
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| Id | Subject | Object | Predicate | Lexical cue | NCBI_Taxonomy | OntoBiotope |
|---|---|---|---|---|---|---|
| T1 | 0-92 | Title | denotes | Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH. | ||
| T3 | 43-64 | Microorganism | denotes | Staphylococcus aureus | 1280 | |
| T4 | 93-102 | Phenotype | denotes | Pathogens | OBT:000375 | |
| T2 | 93-1013 | Paragraph | denotes | Pathogens must steal iron from their hosts to establish infection. In mammals, hemoglobin (Hb) represents the largest reservoir of iron, and pathogens express Hb-binding proteins to access this source. Here, we show how one of the commonest and most significant human pathogens, Staphylococcus aureus, captures Hb as the first step of an iron-scavenging pathway. The x-ray crystal structure of Hb bound to a domain from the Isd (iron-regulated surface determinant) protein, IsdH, is the first structure of a Hb capture complex to be determined. Surface mutations in Hb that reduce binding to the Hb-receptor limit the capacity of S. aureus to utilize Hb as an iron source, suggesting that Hb sequence is a factor in host susceptibility to infection. The demonstration that pathogens make highly specific recognition complexes with Hb raises the possibility of developing inhibitors of Hb binding as antibacterial agents. | ||
| T5 | 163-170 | Habitat | denotes | mammals | OBT:001625 | |
| T6 | 234-243 | Phenotype | denotes | pathogens | OBT:000375 | |
| T8 | 355-360 | Habitat | denotes | human | OBT:002488 | |
| T7 | 355-370 | Phenotype | denotes | human pathogens | OBT:002806 | |
| T9 | 372-393 | Microorganism | denotes | Staphylococcus aureus | 1280 | |
| T10 | 723-732 | Microorganism | denotes | S. aureus | 1280 | |
| T11 | 866-875 | Phenotype | denotes | pathogens | OBT:000375 |