bionlp-ost-19-BB-norm-train  

BB-norm@ldeleger:BB-norm-17237163 JSONTXT

Annnotations TAB TSV DIC JSON TextAE

Below, discontinuous spans are shown in the bag model. You can change it to the chain model.

Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T3 0-14 Phenotype denotes Quorum-sensing OBT:000143
T1 0-86 Title denotes Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent.
T4 29-37 Phenotype denotes adhesion OBT:000029
T5 41-64 Microorganism denotes Serratia marcescens MG1 615
T6 87-106 Microorganism denotes Serratia marcescens 615
T2 87-1888 Paragraph denotes Serratia marcescens is an opportunistic pathogen and a major cause of ocular infections. In previous studies of S. marcescens MG1, we showed that biofilm maturation and sloughing were regulated by N-acyl homoserine lactone (AHL)-based quorum sensing (QS). Because of the importance of adhesion in initiating biofilm formation and infection, the primary goal of this study was to determine whether QS is important in adhesion to both abiotic and biotic surfaces, as assessed by determining the degree of attachment to hydrophilic tissue culture plates and human corneal epithelial (HCE) cells. Our results demonstrate that while adhesion to the abiotic surface was AHL regulated, adhesion to the HCE cell biotic surface was not. Type I fimbriae were identified as the critical adhesin for non-QS-mediated attachment to the biotic HCE cell surface but played no role in adhesion to the abiotic surface. While we were not able to identify a single QS-regulated adhesin essential for attachment to the abiotic surface, four AHL-regulated genes involved in adhesion to the abiotic surface were identified. Interestingly, two of these genes, bsmA and bsmB, were also shown to be involved in adhesion to the biotic surface in a non-QS-controlled fashion. Therefore, the expression of these two genes appears to be cocontrolled by regulators other than the QS system for mediation of attachment to HCE cells. We also found that QS in S. marcescens regulates other potential cell surface adhesins, including exopolysaccharide and the outer membrane protein OmpX. We concluded that S. marcescens MG1 utilizes different regulatory systems and adhesins in attachment to biotic and abiotic surfaces and that QS is a main regulatory pathway in adhesion to an abiotic surface but not in adhesion to a biotic surface.
T7 113-135 Phenotype denotes opportunistic pathogen OBT:000776
T8 157-163 Habitat denotes ocular OBT:000627
T9 199-216 Microorganism denotes S. marcescens MG1 615
T10 233-240 Habitat denotes biofilm OBT:000054
T11 233-251 Phenotype denotes biofilm maturation OBT:001444
T12 284-336 Phenotype denotes N-acyl homoserine lactone (AHL)-based quorum sensing OBT:000143
T13 338-340 Phenotype denotes QS OBT:000143
T14 372-380 Phenotype denotes adhesion OBT:000029
T15 395-402 Habitat denotes biofilm OBT:000054
T16 395-412 Phenotype denotes biofilm formation OBT:001444
T17 484-486 Phenotype denotes QS OBT:000143
T18 503-511 Phenotype denotes adhesion OBT:000029
T20 532-547 Habitat denotes biotic surfaces OBT:000007
T19-1 520-527,539-547 Habitat denotes abiotic surfaces
T21 590-600 Phenotype denotes attachment OBT:000029
T23 604-630 Habitat denotes hydrophilic tissue culture OBT:000062
T22 604-637 Habitat denotes hydrophilic tissue culture plates OBT:000103
T25 642-647 Habitat denotes human OBT:002488
T24 642-678 Habitat denotes human corneal epithelial (HCE) cells OBT:000061
T26 648-655 Habitat denotes corneal OBT:000573
T27 656-666 Habitat denotes epithelial OBT:001091
T28 715-723 Phenotype denotes adhesion OBT:000029
T29 731-746 Habitat denotes abiotic surface OBT:000007
T30 766-774 Phenotype denotes adhesion OBT:000029
T31 782-790 Habitat denotes HCE cell OBT:000061
T32 782-805 Habitat denotes HCE cell biotic surface OBT:000062
T33 879-881 Phenotype denotes QS OBT:000143
T34 891-901 Phenotype denotes attachment OBT:000029
T35 909-932 Habitat denotes biotic HCE cell surface OBT:000062
T36 916-924 Habitat denotes HCE cell OBT:000061
T37 955-963 Phenotype denotes adhesion OBT:000029
T38 971-986 Habitat denotes abiotic surface OBT:000007
T39 1032-1034 Phenotype denotes QS OBT:000143
T40 1067-1077 Phenotype denotes attachment OBT:000029
T41 1085-1100 Habitat denotes abiotic surface OBT:000007
T42 1139-1147 Phenotype denotes adhesion OBT:000029
T43 1155-1170 Habitat denotes abiotic surface OBT:000007
T44 1272-1280 Phenotype denotes adhesion OBT:000029
T45 1288-1302 Habitat denotes biotic surface OBT:000062
T46 1312-1314 Phenotype denotes QS OBT:000143
T47 1436-1438 Phenotype denotes QS OBT:000143
T48 1463-1473 Phenotype denotes attachment OBT:000029
T49 1477-1486 Habitat denotes HCE cells OBT:000061
T50 1507-1509 Phenotype denotes QS OBT:000143
T51 1513-1526 Microorganism denotes S. marcescens 615
T52 1659-1676 Microorganism denotes S. marcescens MG1 615
T53 1731-1741 Phenotype denotes attachment OBT:000029
T55 1756-1772 Habitat denotes abiotic surfaces OBT:000007
T54-1 1745-1751,1764-1772 Habitat denotes biotic surfaces
T56 1782-1784 Phenotype denotes QS OBT:000143
T57 1817-1825 Phenotype denotes adhesion OBT:000029
T58 1832-1847 Habitat denotes abiotic surface OBT:000007
T59 1859-1867 Phenotype denotes adhesion OBT:000029
T60 1873-1887 Habitat denotes biotic surface OBT:000062