bionlp-ost-19-BB-norm-ner-train  

BB-norm+ner@ldeleger:BB-norm+ner-24361838 JSONTXT

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-114 Title denotes Evaluation of a lytic bacteriophage, Φ st1, for biocontrol of Salmonella enterica serovar Typhimurium in chickens.
T3 16-21 Phenotype denotes lytic OBT:000107
T4 37-42 Microorganism denotes Φ st1 12333
T5 62-101 Microorganism denotes Salmonella enterica serovar Typhimurium 90371
T6 105-113 Habitat denotes chickens OBT:003314
T2 115-2050 Paragraph denotes In this study, a Salmonella Typhimurium lytic bacteriophage, Φ st1, which was isolated from chicken faecal material, was evaluated as a candidate for biocontrol of Salmonella in chickens. The morphology of Φ st1 showed strong resemblance to members of the Siphoviridae family. Φ st1 was observed to be a DNA phage with an estimated genome size of 121 kbp. It was found to be able to infect S. Typhimurium and S. Hadar, with a stronger lytic activity against the former. Subsequent characterisation of Φ st1 against S. Typhimurium showed that Φ st1 has a latent period of 40 min with an average burst size of 22 particles per infective centre. Approximately 86.1% of the phage adsorbed to the host cells within the initial 5 min of infection. At the optimum multiplicity of infection (MOI) (0.1), the highest reduction rate of S. Typhimurium (6.6 log₁₀ CFU/ml) and increment in phage titre (3.8 log₁₀ PFU/ml) was observed. Φ st1 produced adsorption rates of 88.4-92.2% at pH7-9 and demonstrated the highest bacteria reduction (6.6 log₁₀ CFU/ml) at pH9. Φ st1 also showed an insignificant different (P>0.05) reduction rate of host cells at 37 °C (6.4 log₁₀ CFU/ml) and 42 °C (6.0 log₁₀ CFU/ml). The in vivo study using Φ st1 showed that intracloacal inoculation of ~10¹² PFU/ml of the phage in the chickens challenged with ~10¹⁰ CFU/ml of S. Typhimurium was able to reduce (P<0.05) the S. Typhimurium more rapidly than the untreated group. The Salmonella count reduced to 2.9 log₁₀ CFU/ml within 6h of post-challenge and S. Typhimurium was not detected at and after 24h of post-challenge. Reduction of Salmonella count in visceral organs was also observed at 6h post-challenge. Approximately 1.6 log₁₀ FU/ml Φ st1 was found to persist in the caecal wall of the chicks at 72 h of post-challenge. The present study indicated that Φ st1 may serve as a potential biocontrol agent to reduce the Salmonella count in caecal content of chickens.
T8 132-154 Microorganism denotes Salmonella Typhimurium 90371
T7 132-174 Microorganism denotes Salmonella Typhimurium lytic bacteriophage 12333
T9 155-160 Phenotype denotes lytic OBT:000107
T10 176-181 Microorganism denotes Φ st1 12333
T11 207-214 Habitat denotes chicken OBT:003314
T12 207-230 Habitat denotes chicken faecal material OBT:001102
T13 279-289 Microorganism denotes Salmonella 590
T14 293-301 Habitat denotes chickens OBT:003314
T15 321-326 Microorganism denotes Φ st1 12333
T16 371-383 Microorganism denotes Siphoviridae 10699
T17 392-397 Microorganism denotes Φ st1 12333
T18 505-519 Microorganism denotes S. Typhimurium 90371
T19 524-532 Microorganism denotes S. Hadar 149385
T20 550-564 Phenotype denotes lytic activity OBT:000107
T21 616-621 Microorganism denotes Φ st1 12333
T22 630-644 Microorganism denotes S. Typhimurium 90371
T23 657-662 Microorganism denotes Φ st1 12333
T24 807-817 Habitat denotes host cells OBT:000061
T25 941-955 Microorganism denotes S. Typhimurium 90371
T26 1037-1042 Microorganism denotes Φ st1 12333
T27 1167-1172 Microorganism denotes Φ st1 12333
T28 1239-1249 Habitat denotes host cells OBT:000061
T29 1332-1337 Microorganism denotes Φ st1 12333
T30 1350-1362 Habitat denotes intracloacal OBT:001488
T31 1411-1419 Habitat denotes chickens OBT:003314|OBT:000700
T32 1452-1466 Microorganism denotes S. Typhimurium 90371
T33 1499-1513 Microorganism denotes S. Typhimurium 90371
T34 1557-1567 Microorganism denotes Salmonella 590
T35 1634-1648 Microorganism denotes S. Typhimurium 90371
T36 1715-1725 Microorganism denotes Salmonella 590
T37 1735-1750 Habitat denotes visceral organs OBT:000364
T38 1821-1826 Microorganism denotes Φ st1 12333
T39 1855-1861 Habitat denotes caecal OBT:001471
T40 1855-1880 Habitat denotes caecal wall of the chicks OBT:001006
T41 1874-1880 Habitat denotes chicks OBT:000700|OBT:003314|OBT:003263
T42 1941-1946 Microorganism denotes Φ st1 12333
T43 2003-2013 Microorganism denotes Salmonella 590
T45 2023-2029 Habitat denotes caecal OBT:001471
T44 2023-2049 Habitat denotes caecal content of chickens OBT:001470
T46 2041-2049 Habitat denotes chickens OBT:003314