bionlp-ost-19-BB-norm-dev  

BB-norm@ldeleger:BB-norm-19339076 / 133-2382 JSONTXT

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T7 0-4 Habitat denotes Bile OBT:000514
T6 0-15 Phenotype denotes Bile resistance OBT:000152
T2 0-2249 Paragraph denotes Bile resistance is one of the basic characteristics of probiotic bacteria. The aim of this study was to investigate the characteristics of bile resistance in lactococci by studying the relationship between bile resistance and cellular fatty acid composition in lactococcci grown on different media. We determined the bile resistance of 14 strains in lactose-free M17 medium supplemented with either glucose only (GM17) or lactose only (LM17). Gas chromatographic analyses of free lipids extracted from the tested strains were used for determining their fatty acid composition. A correlation analysis of all strains grown in both media revealed significant positive correlations between bile resistance and relative contents of hexadecanoic acid and octadecenoic acid, and negative correlations between bile resistance and relative contents of hexadecenoic acid and C-19 cyclopropane fatty acid. It is also a fact that the fatty acids associated with bile resistance depended on species, strain, and/or growth medium. In L. lactis subsp. cremoris strains grown in GM17 medium, the bile-resistant strains had significantly more octadecenoic acid than the bile-sensitive strains. In LM17 medium, bile-resistant strains had significantly more octadecenoic acid and significantly less C-19 cyclopropane fatty acid than the bile-sensitive strains. In L. lactis subsp. lactis strains, bile resistances of some of the tested strains were altered by growth medium. Some strains were resistant to bile in GM17 medium but sensitive to bile in LM17 medium. Some strains were resistant in both media tested. The strains grown in GM17 medium had significantly more hexadecanoic acid and octadecenoic acid, and significantly less tetradecanoic acid, octadecadienoic acid and C-19 cyclopropane fatty acid than the strains grown in LM17 medium. In conclusion, the fatty acid compositions of the bile-resistant lactococci differed from those of the bile-sensitive ones. More importantly, our data suggest that altering their fatty acid composition (i.e. increased hexadecanoic acid and octadecenoic acid and decreased hexadecenoic acid and C-19 cyclopropane fatty acid) by changing growth conditions may be a useful way to enhance their bile resistance in lactococci.
T8 55-64 Phenotype denotes probiotic OBT:000827
T10 139-143 Habitat denotes bile OBT:000514
T9 139-154 Phenotype denotes bile resistance OBT:000152
T11 158-168 Microorganism denotes lactococci 1357
T13 206-210 Habitat denotes bile OBT:000514
T12 206-221 Phenotype denotes bile resistance OBT:000152
T14 261-272 Microorganism denotes lactococcci 1357
T16 317-321 Habitat denotes bile OBT:000514
T15 317-332 Phenotype denotes bile resistance OBT:000152
T17-0 350-391 _FRAGMENT denotes lactose-free M17 medium supplemented with OBT:000007
T18-0 350-391 _FRAGMENT denotes lactose-free M17 medium supplemented with OBT:000007
T17-1 399-418 Habitat denotes glucose only (GM17)
T18-1 422-441 Habitat denotes lactose only (LM17)
T20 686-690 Habitat denotes bile OBT:000514
T19 686-701 Phenotype denotes bile resistance OBT:000152
T22 802-806 Habitat denotes bile OBT:000514
T21 802-817 Phenotype denotes bile resistance OBT:000152
T24 950-954 Habitat denotes bile OBT:000514
T23 950-965 Phenotype denotes bile resistance OBT:000152
T25 1020-1045 Microorganism denotes L. lactis subsp. cremoris 1359
T26 1063-1074 Habitat denotes GM17 medium OBT:000007
T28 1080-1084 Habitat denotes bile OBT:000514
T27 1080-1094 Phenotype denotes bile-resistant OBT:000152
T30 1153-1157 Habitat denotes bile OBT:000514
T29 1153-1167 Phenotype denotes bile-sensitive OBT:000153
T31 1180-1191 Habitat denotes LM17 medium OBT:000007
T33 1193-1197 Habitat denotes bile OBT:000514
T32 1193-1207 Phenotype denotes bile-resistant OBT:000152
T35 1318-1322 Habitat denotes bile OBT:000514
T34 1318-1332 Phenotype denotes bile-sensitive OBT:000153
T36 1345-1368 Microorganism denotes L. lactis subsp. lactis 1360
T38 1378-1382 Habitat denotes bile OBT:000514
T37 1378-1394 Phenotype denotes bile resistances OBT:000152
T39 1474-1491 Phenotype denotes resistant to bile OBT:000152
T40 1487-1491 Habitat denotes bile OBT:000514
T41 1495-1506 Habitat denotes GM17 medium OBT:000007
T42 1511-1528 Phenotype denotes sensitive to bile OBT:000153
T43 1524-1528 Habitat denotes bile OBT:000514
T44 1532-1543 Habitat denotes LM17 medium OBT:000007
T45 1563-1572 Phenotype denotes resistant OBT:000152
T46 1616-1627 Habitat denotes GM17 medium OBT:000007
T47 1815-1826 Habitat denotes LM17 medium OBT:000007
T49 1878-1882 Habitat denotes bile OBT:000514
T48 1878-1892 Phenotype denotes bile-resistant OBT:000152
T50 1893-1903 Microorganism denotes lactococci 1357
T52 1931-1935 Habitat denotes bile OBT:000514
T51 1931-1945 Phenotype denotes bile-sensitive OBT:000153
T54 2219-2223 Habitat denotes bile OBT:000514
T53 2219-2234 Phenotype denotes bile resistance OBT:000152
T55 2238-2248 Microorganism denotes lactococci 1357
C-T17-0 T17-1 T17-0 _lexicallyChainedTo glucose only (GM17),lactose-free M17 medium supplemented with
C-T18-0 T18-1 T18-0 _lexicallyChainedTo lactose only (LM17),lactose-free M17 medium supplemented with