BB-kb@ldeleger:BB-kb-10658649
Annnotations
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue | NCBI_Taxonomy | OntoBiotope |
|---|---|---|---|---|---|---|
| T1 | 0-108 | Title | denotes | Identification of a novel glycoprotein-binding activity in Streptococcus pyogenes regulated by the mga gene. | ||
| T3 | 26-55 | Phenotype | denotes | glycoprotein-binding activity | OBT:000019 | |
| T4 | 59-81 | Microorganism | denotes | Streptococcus pyogenes | 1314 | |
| E1 | 59-81 | Exhibits | denotes | Streptococcus pyogenes | ||
| T2 | 109-1148 | Paragraph | denotes | The interaction between Streptococcus pyogenes and the host cell surface is not completely understood. Characterization of the adhesion mechanisms of the bacterium to the host cell surface is needed in order to develop new vaccines and anti-adhesion drugs. The presence of glycoprotein-binding activities among streptococcal strains was investigated. An activity binding to thyroglobulin, fetuin, asialofetuin and mucin but not non-glycosylated proteins was found to be present in the majority of the S. pyogenes strains studied. Cross-inhibition experiments suggested that the glycoproteins share a common structure recognized by the bacteria. The glycoprotein-binding activity was found to be proteinaceous, tightly attached to the bacterial surface and it also mediated the adherence of bacteria to solid surfaces coated with glycoproteins. The activity was found by transposon mutagenesis and complementation to be regulated by the multiple-gene regulator Mga, which has been implicated as a regulator of S. pyogenes virulence factors. | ||
| T5 | 133-155 | Microorganism | denotes | Streptococcus pyogenes | 1314 | |
| E2 | 133-155 | Exhibits | denotes | Streptococcus pyogenes | ||
| T6 | 164-173 | Habitat | denotes | host cell | OBT:000061 | |
| T7 | 236-255 | Phenotype | denotes | adhesion mechanisms | OBT:000029 | |
| T8 | 280-289 | Habitat | denotes | host cell | OBT:000061 | |
| T9 | 332-340 | Habitat | denotes | vaccines | OBT:000464 | |
| T10 | 382-413 | Phenotype | denotes | glycoprotein-binding activities | OBT:000019 | |
| T11 | 420-433 | Microorganism | denotes | streptococcal | 1314 | |
| T12-0 | 463-482 | _FRAGMENT | denotes | activity binding to | OBT:000019 | |
| T13-0 | 463-482 | _FRAGMENT | denotes | activity binding to | OBT:000019 | |
| T15-0 | 463-482 | _FRAGMENT | denotes | activity binding to | OBT:000019 | |
| T14 | 463-496 | Phenotype | denotes | activity binding to thyroglobulin | OBT:000019 | |
| T12-1 | 498-504 | Phenotype | denotes | fetuin | ||
| T13-1 | 506-518 | Phenotype | denotes | asialofetuin | ||
| T15-1 | 523-528 | Phenotype | denotes | mucin | ||
| T16 | 610-621 | Microorganism | denotes | S. pyogenes | 1314 | |
| E3 | 610-621 | Exhibits | denotes | S. pyogenes | ||
| E4 | 610-621 | Exhibits | denotes | S. pyogenes | ||
| E5 | 610-621 | Exhibits | denotes | S. pyogenes | ||
| E6 | 610-621 | Exhibits | denotes | S. pyogenes | ||
| T17 | 758-787 | Phenotype | denotes | glycoprotein-binding activity | OBT:000019 | |
| T18 | 886-895 | Phenotype | denotes | adherence | OBT:000029 | |
| T19 | 1118-1129 | Microorganism | denotes | S. pyogenes | 1314 | |
| E7 | 1118-1129 | Exhibits | denotes | S. pyogenes | ||
| T20 | 1130-1139 | Phenotype | denotes | virulence | OBT:000375 | |
| C-T12-0 | T12-1 | T12-0 | _lexicallyChainedTo | fetuin,activity binding to | ||
| C-T13-0 | T13-1 | T13-0 | _lexicallyChainedTo | asialofetuin,activity binding to | ||
| C-T15-0 | T15-1 | T15-0 | _lexicallyChainedTo | mucin,activity binding to | ||
| R1 | E1 | T4 | Microorganism | Streptococcus pyogenes,Streptococcus pyogenes | ||
| R10 | E5 | T12-0 | Property | S. pyogenes,activity binding to | ||
| R11 | E6 | T16 | Microorganism | S. pyogenes,S. pyogenes | ||
| R12 | E6 | T14 | Property | S. pyogenes,activity binding to thyroglobulin | ||
| R13 | E7 | T19 | Microorganism | S. pyogenes,S. pyogenes | ||
| R14 | E7 | T20 | Property | S. pyogenes,virulence | ||
| R2 | E1 | T3 | Property | Streptococcus pyogenes,glycoprotein-binding activity | ||
| R3 | E2 | T5 | Microorganism | Streptococcus pyogenes,Streptococcus pyogenes | ||
| R4 | E2 | T7 | Property | Streptococcus pyogenes,adhesion mechanisms | ||
| R5 | E3 | T16 | Microorganism | S. pyogenes,S. pyogenes | ||
| R6 | E3 | T13-0 | Property | S. pyogenes,activity binding to | ||
| R7 | E4 | T16 | Microorganism | S. pyogenes,S. pyogenes | ||
| R8 | E4 | T15-0 | Property | S. pyogenes,activity binding to | ||
| R9 | E5 | T16 | Microorganism | S. pyogenes,S. pyogenes |