bionlp-ost-19-BB-kb-ner-train  

BB-kb+ner@ldeleger:BB-kb+ner-19501788 JSONTXT

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-123 Title denotes Construction of an attenuated Pseudomonas fluorescens strain and evaluation of its potential as a cross-protective vaccine.
T3 30-53 Microorganism denotes Pseudomonas fluorescens 294
T4 98-122 Habitat denotes cross-protective vaccine OBT:000464
T2 124-1683 Paragraph denotes Ferric uptake regulator (Fur) is a global transcription regulator that is ubiquitous to Gram-negative bacteria and regulates diverse biological processes, including iron uptake, cellular metabolism, stress response, and production of virulence determinants. As a result, for many pathogenic bacteria, Fur plays a crucial role in the course of infection and disease development. In this study, the fur gene was cloned from a pathogenic Pseudomonas fluorescens strain, TSS, isolated from diseased Japanese flounder cultured in a local farm. TSS Fur can partially complement the defective phenotype of an Escherichia coli fur mutant. A TSS fur null mutant, TFM, was constructed. Compared to TSS, TFM exhibits reduced growth ability, aberrant production of outer membrane proteins, decreased resistance against host serum bactericidal activity, impaired ability to disseminate in host blood and tissues, and drastic attenuation in overall bacterial virulence in a Japanese flounder infection model. When used as a live vaccine administered via the injection, immersion, and oral routes, TFM affords high levels of protection upon Japanese flounder against not only P. fluorescens infection but also Aeromonas hydrophila infection. Furthermore, a plasmid, pJAQ, was constructed, which expresses the coding element of the Vibrio harveyi antigen AgaV-DegQ. TFM harboring pJAQ can secret AgaV-DegQ into the extracellular milieu. Vaccination of Japanese flounder with live TFM/pJAQ elicited strong immunoprotection against both V. harveyi and A. hydrophila infections.
T5 212-225 Phenotype denotes Gram-negative OBT:000648
T6 358-367 Phenotype denotes virulence OBT:000375
T7 404-414 Phenotype denotes pathogenic OBT:000375
T8 548-558 Phenotype denotes pathogenic OBT:002669
T9 559-594 Microorganism denotes Pseudomonas fluorescens strain, TSS 294
E1 559-594 Lives_In denotes Pseudomonas fluorescens strain, TSS
E2 559-594 Lives_In denotes Pseudomonas fluorescens strain, TSS
E3 559-594 Exhibits denotes Pseudomonas fluorescens strain, TSS
T10 610-661 Habitat denotes diseased Japanese flounder cultured in a local farm OBT:000491|OBT:003553
T11 651-661 Habitat denotes local farm OBT:000630
T12 663-666 Microorganism denotes TSS 294
T13 726-742 Microorganism denotes Escherichia coli 562
T14 743-753 Phenotype denotes fur mutant OBT:000118
T15 757-760 Microorganism denotes TSS 294
T16 761-776 Phenotype denotes fur null mutant OBT:000118
T17 778-781 Microorganism denotes TFM 562
T18 812-815 Microorganism denotes TSS 294
T19 817-820 Microorganism denotes TFM 562
E4 817-820 Lives_In denotes TFM
E5 817-820 Lives_In denotes TFM
E6 817-820 Exhibits denotes TFM
T20 902-963 Phenotype denotes decreased resistance against host serum bactericidal activity OBT:000152
T21 931-941 Habitat denotes host serum OBT:000524
T22-0 1000-1004 _FRAGMENT denotes host OBT:000196
T23 1000-1010 Habitat denotes host blood OBT:000521
T22-1 1015-1022 Habitat denotes tissues
T24 1059-1078 Phenotype denotes bacterial virulence OBT:002669
T25 1084-1101 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T26 1134-1146 Habitat denotes live vaccine OBT:000464
T27 1194-1198 Habitat denotes oral OBT:001653
T28 1207-1210 Microorganism denotes TFM 562
E7 1207-1210 Lives_In denotes TFM
E8 1207-1210 Lives_In denotes TFM
T29 1250-1267 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T30 1285-1299 Microorganism denotes P. fluorescens 294
T31 1319-1339 Microorganism denotes Aeromonas hydrophila 644
T32 1440-1454 Microorganism denotes Vibrio harveyi 669
T33 1474-1477 Microorganism denotes TFM 562
T34 1560-1577 Habitat denotes Japanese flounder OBT:000700|OBT:003553
T35 1588-1591 Microorganism denotes TFM 562
E9 1588-1591 Lives_In denotes TFM
T36 1643-1653 Microorganism denotes V. harveyi 669
T37 1658-1671 Microorganism denotes A. hydrophila 644
C-T22-0 T22-1 T22-0 _lexicallyChainedTo tissues,host
R1 E1 T9 Microorganism "Pseudomonas fluorescens strain, TSS","Pseudomonas fluorescens strain, TSS"
R10 E5 T25 Location TFM,Japanese flounder
R11 E6 T19 Microorganism TFM,TFM
R12 E6 T20 Property TFM,decreased resistance against host serum bactericidal activity
R13 E7 T28 Microorganism TFM,TFM
R14 E7 T29 Location TFM,Japanese flounder
R15 E8 T28 Microorganism TFM,TFM
R16 E8 T26 Location TFM,live vaccine
R17 E9 T35 Microorganism TFM,TFM
R18 E9 T34 Location TFM,Japanese flounder
R2 E1 T11 Location "Pseudomonas fluorescens strain, TSS",local farm
R3 E2 T9 Microorganism "Pseudomonas fluorescens strain, TSS","Pseudomonas fluorescens strain, TSS"
R4 E2 T10 Location "Pseudomonas fluorescens strain, TSS",diseased Japanese flounder cultured in a local farm
R5 E3 T9 Microorganism "Pseudomonas fluorescens strain, TSS","Pseudomonas fluorescens strain, TSS"
R6 E3 T8 Property "Pseudomonas fluorescens strain, TSS",pathogenic
R7 E4 T19 Microorganism TFM,TFM
R8 E4 T21 Location TFM,host serum
R9 E5 T19 Microorganism TFM,TFM