| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-89 |
DRI_Background |
denotes |
Alzheimer's soluble amyloid beta protein is secreted by HepG2 cells as an apolipoprotein. |
| T2 |
90-260 |
DRI_Approach |
denotes |
Recently we reported that the soluble form of amyloid beta protein (sA beta) in normal human plasma and cerebrospinal fluid is associated with lipoprotein (LP) particles. |
| T3 |
261-364 |
DRI_Approach |
denotes |
In this paper we tested the sA beta secretion by cells in association with LP in the model of the human |
| T4 |
365-379 |
Token_Label.OUTSIDE |
denotes |
hepatoma HepG2 |
| T5 |
380-390 |
DRI_Approach |
denotes |
cell line. |
| T6 |
391-494 |
DRI_Background |
denotes |
These cells secreted sA beta to the culture media and expressed intracellular sA beta immunoreactivity. |
| T7 |
495-693 |
DRI_Background |
denotes |
Soluble A beta in the cell supernatant was detected in 200-300 kDa LP complexes in association with apoA-I, apoJ, transthyrethin and phospholipids, triglycerides and free and esterified cholesterol. |
| T8 |
694-867 |
DRI_Background |
denotes |
This was assessed by size exclusion HPLC, immunoprecipitation with corresponding antibodies and by analysis of sA beta associated metabolically-labeled lipids, respectively. |
| T9 |
868-990 |
DRI_Outcome |
denotes |
Our results suggest that sA beta to LP association represents a unique mechanism, governing the normal biology of sA beta. |
