UseCases_ArguminSci_Discourse  

PubMed:8712293 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-148 DRI_Background denotes Endocrine ductal carcinoma in situ (E-DCIS) of the breast: a form of low-grade DCIS with distinctive clinicopathologic and biologic characteristics.
T2 149-229 DRI_Background denotes Endocrine ductal carcinoma in situ (E-DCIS), first characterized by Cross et al.
T3 230-362 DRI_Background denotes in 1985, is an uncommon entity, and there is little information on its pathobiologic features and natural history in the literature.
T4 363-514 DRI_Outcome denotes This report describes the largest series of 34 cases: 14 cases were pure in situ (group A), and 20 were accompanied by an invasive component (group B).
T5 515-642 DRI_Approach denotes All except three patients were over the age of 60 years, with the mean being 69.5 years for group A and 72.6 years for group B.
T6 643-726 DRI_Approach denotes Except for six patients in group A who had nipple discharge, all had a breast mass.
T7 727-920 DRI_Background denotes On follow-up, one of five group A patients developed local recurrence 5 years after mastectomy, and two of seven group B patients developed another invasive primary in the contralateral breast.
T8 921-1057 DRI_Unspecified denotes Histologically, E-DCIS showed expansile intraductal growths forming solid sheets and festoons traversed by delicate fibrovascular septa.
T9 1058-1152 DRI_Outcome denotes Accumulation of basophilic mucin might be found within the growth and the fibrovascular septa.
T10 1153-1202 DRI_Approach denotes There were variable degrees of stromal sclerosis.
T11 1203-1326 DRI_Background denotes In some cases, the solid intraductal cellular proliferations were focally punctuated by microglandular spaces and rosettes.
T12 1327-1354 DRI_Unspecified denotes Comedo necrosis was absent.
T13 1355-1494 DRI_Outcome denotes Intraductal papillomas were found in the immediate vicinity of the tumors in 18 cases and invariably showed pagetoid involvement by E-DCIS.
T14 1495-1585 DRI_Approach denotes Pagetoid spread into the adjacent ducts and ductules was also a common feature (17 cases).
T15 1586-1742 DRI_Background denotes The tumor cells were polygonal, oval, or spindly, often with eccentrically placed, bland-looking, ovoid nuclei and abundant eosinophilic granular cytoplasm.
T16 1743-1789 DRI_Background denotes Intracellular mucin was commonly demonstrable.
T17 1790-1913 DRI_Background denotes Immunostaining for myoepithelium using muscle-specific actin antibody confirmed the in situ nature of the E-DCIS component.
T18 1914-2067 DRI_Outcome denotes The majority of tumor cells showed strong staining with the neuroendocrine markers chromogranin, synaptophysin, and neuron-specific enolase (monoclonal).
T19 2068-2271 DRI_Outcome denotes Immunostaining also dramatically highlighted the pagetoid spread into the papillomas and ductules by outlining the tumor cells between the negatively stained residual ductal epithelium and myoepithelium.
T20 2272-2366 DRI_Outcome denotes All cases were immunoreactive for estrogen and progesterone receptor, but not p53 and c-erbB2.
T21 2367-2392 DRI_Unspecified denotes The Ki-67 index was < 5%.
T22 2393-2506 DRI_Background denotes Ultrastructural studies on four cases showed many dense-core neurosecretory granules and larger mucigen granules.
T23 2507-2722 DRI_Background denotes In group B cases, the invasive component, which comprised 5-95% of the tumor, included colloid carcinoma, 12; "carcinoid" tumor, 3; mixed "carcinoid"/colloid carcinoma, 4; and small cell neuroendocrine carcinoma, 1.
T24 2723-2808 DRI_Background denotes Neuroendocrine markers were also consistently demonstrable in the invasive component.
T25 2809-3024 DRI_Background denotes In conclusion, E-DCIS is predominantly a disease of older women that is frequently accompanied by papillomas in the vicinity and may present as nipple discharge (an uncommon presentation in the usual forms of DCIS).
T26 3025-3134 DRI_Outcome denotes It can mimic epitheliosis histologically, but the pagetoid spread is a helpful clue to its neoplastic nature.
T27 3135-3292 DRI_Background denotes The bland nuclear morphology, lack of necrosis, and biologic marker profile suggest that E-DCIS is a form of low-grade DCIS despite its solid growth pattern.
T28 3293-3503 DRI_Background denotes The invasive carcinomas associated with E-DCIS are also neuroendocrine programmed rather than the usual types of ductal carcinomas, suggesting that E-DCIS represents a biologically distinctive category of DCIS.