UseCases_ArguminSci_Discourse  

PubMed:8646681 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-62 DRI_Background denotes Extensive apoptosis in ductal carcinoma in situ of the breast.
T2 75-273 DRI_Background denotes More than 50% of breast ductal carcinomas in situ (DCIS) contain significant histologic necrosis, an important prognostic factor for determining recurrence and progression to invasive breast cancer.
T3 274-484 DRI_Approach denotes We have examined whether the mechanism of this spontaneous cell death might be apoptosis, a genetically encoded suicide pathway that may be triggered by various events including dysregulated cell proliferation.
T4 494-893 DRI_Background denotes Twenty-five untreated DCIS cases accessioned at our institution were examined for subtype, grade, and presence of apoptosis using two criteria: (1) cellular morphology (shrinkage, nuclear condensation, fragmentation, apoptotic bodies, and lack of inflammatory component); and (2) terminal transferase (TUNEL) staining of DNA fragmentation, a characteristic though less specific feature of apoptosis.
T5 894-1039 DRI_Approach denotes Immunohistochemical staining was also carried out to assess whether wild-type p53, a regulator of apoptosis, was associated with this cell death.
T6 1049-1209 DRI_Outcome denotes In all 19 cases with intraductal necrosis, cellular morphology was consistent with apoptotic death, despite its presence within sheets of "geographic necrosis."
T7 1210-1279 DRI_Approach denotes Additionally, the identical regions were all strongly TUNEL-positive.
T8 1280-1372 DRI_Outcome denotes No evidence of TUNEL staining was seen in 5 Grade I DCIS cases without intraductal necrosis.
T9 1373-1473 DRI_Background denotes Immunohistochemical staining suggested that this apoptosis was independent of p53 mutational status.
T10 1487-1559 DRI_Background denotes Extensive intraductal necrosis in DCIS is likely to represent apoptosis.
T11 1560-1624 DRI_Approach denotes However, it is unlikely that this apoptosis is regulated by p53.
T12 1625-1812 DRI_Background denotes The apparently abundant apoptosis identified here, particularly in high grade DCIS, may be important in explaining why spontaneous cell death in DCIS is associated with a worse prognosis.