UseCases_ArguminSci_Discourse  

PubMed:28707729 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-72 DRI_Background denotes SOX11 promotes invasive growth and ductal carcinoma in situ progression.
T2 73-208 DRI_Outcome denotes Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen
T3 209-238 Token_Label.OUTSIDE denotes receptor-negative preinvasive
T4 239-279 DRI_Outcome denotes ductal carcinoma in situ (DCIS) lesions.
T5 280-533 DRI_Background denotes Mature mammary epithelial cells engineered to express SOX11 showed alterations in progenitor cell populations, including an expanded basal-like population with increased aldehyde dehydrogenase (ALDH) activity, and increased mammosphere-forming capacity.
T6 534-649 DRI_Background denotes DCIS.com cells engineered to express SOX11 showed increased ALDH activity, which is a feature of cancer stem cells.
T7 650-741 DRI_Background denotes The CD44+/CD24-/ALDH+ cell population was increased in DCIS.com cells that expressed SOX11.
T8 742-754 REPLACED denotes Upregulating
T9 755-760 Token_Label.OUTSIDE denotes SOX11
T10 761-937 DRI_Outcome denotes expression in DCIS.com cells led to increased invasive growth both in vitro and when they were injected intraductally in a mouse model of DCIS that recapitulates human disease.
T11 938-1097 DRI_Background denotes Invasive lesions formed sooner and tumour growth was augmented in vivo, suggesting that SOX11 contributes to the progression of DCIS to invasive breast cancer.
T12 1098-1330 DRI_Outcome denotes We identified potential downstream effectors of SOX11 during both microinvasive and invasive tumour growth stages, including several with established links to regulation of progenitor cell function and prenatal developmental growth.
T13 1331-1516 DRI_Outcome denotes Our findings suggest that SOX11 is a potential biomarker for DCIS lesions containing cells harbouring distinct biological features that are likely to progress to invasive breast cancer.
T14 1517-1536 DRI_Unspecified denotes © 2017 The Authors.
T15 1537-1660 DRI_Background denotes The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.