UseCases_ArguminSci_Discourse  

PubMed:26343330 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-83 DRI_Background denotes Myoepithelial Cell Differentiation Markers in Ductal Carcinoma in Situ Progression.
T2 84-301 DRI_Challenge denotes We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive disease.
T3 302-467 DRI_Background denotes Human breast cancer MCF10DCIS.com cells were delivered into the mouse mammary teat by intraductal injection in the absence of surgical manipulations and accompanying
T4 468-493 Token_Label.OUTSIDE denotes wound-healing confounders
T5 493-494 DRI_Background denotes .
T6 495-611 DRI_Outcome denotes DCIS-like lesions developed throughout the mammary ducts with full representation of human DCIS histologic patterns.
T7 612-870 DRI_Background denotes Tumor cells were incorporated into the normal mammary epithelium, developed ductal intraepithelial neoplasia and DCIS, and progressed to invasive carcinoma, suggesting the model provides a rigorous approach to study early stages of breast cancer progression.
T8 871-961 DRI_Background denotes Mammary glands were evaluated for myoepithelium integrity with immunohistochemical assays.
T9 962-1142 DRI_Background denotes Progressive loss of the myoepithelial cell differentiation markers p63, calponin, and α-smooth muscle actin was observed in the mouse myoepithelium surrounding DCIS-involved ducts.
T10 1143-1277 DRI_Background denotes p63 loss was an early indicator, calponin loss intermediate, and α-smooth muscle actin a later indicator of compromised myoepithelium.
T11 1278-1285 DRI_Background denotes Loss of
T12 1286-1308 Token_Label.OUTSIDE denotes myoepithelial calponin
T13 1309-1395 DRI_Background denotes was specifically associated with gain of the basal marker p63 in adjacent tumor cells.
T14 1396-1533 DRI_Approach denotes In single time point biopsies obtained from 16 women diagnosed with pure DCIS, a similar loss in myoepithelial cell markers was observed.
T15 1534-1695 DRI_Background denotes These results suggest that further research is warranted into the role of myoepithelial cell p63 and calponin expression on DCIS progression to invasive disease.