UseCases_ArguminSci_Discourse  

PubMed:25572806 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-108 DRI_Background denotes Human mammary microenvironment better regulates the biology of human breast cancer in humanized mouse model.
T2 109-229 DRI_Background denotes During the past decades, many efforts have been made in mimicking the clinical progress of human cancer in mouse models.
T3 230-302 DRI_Approach denotes Previously, we developed a human breast tissue-derived (HB) mouse model.
T4 303-446 DRI_Outcome denotes Theoretically, it may mimic the interactions between "species-specific" mammary microenvironment of human origin and human breast cancer cells.
T5 447-486 DRI_Background denotes However, detailed evidences are absent.
T6 487-675 DRI_Background denotes The present study (in vivo, cellular, and molecular experiments) was designed to explore the regulatory role of human mammary microenvironment in the progress of human breast cancer cells.
T7 676-778 DRI_Background denotes Subcutaneous (SUB), mammary fat pad (MFP), and HB mouse models were developed for in vivo comparisons.
T8 779-882 DRI_Background denotes Then, the orthotopic tumor masses from three different mouse models were collected for primary culture.
T9 883-1001 DRI_Background denotes Finally, the biology of primary cultured human breast cancer cells was compared by cellular and molecular experiments.
T10 1002-1121 DRI_Background denotes Results of in vivo mouse models indicated that human breast cancer cells grew better in human mammary microenvironment.
T11 1122-1332 DRI_Background denotes Cellular and molecular experiments confirmed that primary cultured human breast cancer cells from HB mouse model showed a better proliferative and anti-apoptotic biology than those from SUB to MFP mouse models.
T12 1333-1514 DRI_Background denotes Meanwhile, primary cultured human breast cancer cells from HB mouse model also obtained the migratory and invasive biology for "species-specific" tissue metastasis to human tissues.
T13 1515-1791 DRI_Outcome denotes Comprehensive analyses suggest that "species-specific" mammary microenvironment of human origin better regulates the biology of human breast cancer cells in our humanized mouse model of breast cancer, which is more consistent with the clinical progress of human breast cancer.