UseCases_ArguminSci_Discourse  

PubMed:24830390 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-157 DRI_Challenge denotes (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse.
T2 158-330 DRI_Background denotes Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells.
T3 331-550 DRI_Challenge denotes In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 also causes an early-phase neuronal dysfunction of SNpc dopaminergic cells in the (G2019S) LRRK2 mouse.
T4 551-748 DRI_Outcome denotes Eight to nine-month-old (G2019S) LRRK2 transgenic mice exhibited the symptom of hypoactivity in the absence of the degeneration of SNpc dopaminergic neurons or nigrostriatal dopaminergic terminals.
T5 749-759 REPLACED denotes Whole-cell
T6 760-773 Token_Label.OUTSIDE denotes current-clamp
T7 774-960 DRI_Background denotes recordings of SNpc dopaminergic cells in brain slices demonstrated a significant decrease in spontaneous firing frequency of SNpc dopaminergic neurons of 8-month-old (G2019S) LRRK2 mice.
T8 961-1171 DRI_Approach denotes Carbon fiber electrode amperometry recording using striatal slices showed that (G2019S) LRRK2 transgenic mice at the age of 8 to 9months display an impaired evoked dopamine release in the dorsolateral striatum.
T9 1172-1367 DRI_Background denotes Normal nigrostriatal dopaminergic transmission is required for the induction of long-term synaptic plasticity expressed at corticostriatal glutamatergic synapses of striatal medium spiny neurons.
T10 1368-1378 REPLACED denotes Whole-cell
T11 1379-1392 Token_Label.OUTSIDE denotes voltage-clamp
T12 1393-1590 DRI_Background denotes recordings showed that in contrast to medium spiny neurons of 8 to 9-month-old wild-type mice, high-frequency stimulation of corticostriatal afferents failed to induce long-term depression (LTD) of
T13 1591-1612 Token_Label.OUTSIDE denotes corticostriatal EPSCs
T14 1613-1676 DRI_Background denotes in medium spiny neurons of (G2019S) LRRK2 mice at the same age.
T15 1677-1967 DRI_Outcome denotes Our study provides the evidence that mutant (G2019S) LRRK2 causes early-phase dysfunctions of SNpc dopaminergic neurons, including a decrease in spontaneous firing rate and a reduction in evoked dopamine release, and impairment of corticostriatal LTD in the (G2019S) LRRK2 transgenic mouse.