UseCases_ArguminSci_Discourse  

PubMed:24652679 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-155 DRI_Background denotes Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
T2 156-316 DRI_Background denotes Increasing evidence suggests that Parkinson's disease (PD)-linked Leucine-rich repeat kinase 2 (LRRK2) has a role in peripheral and brain-resident immune cells.
T3 317-478 DRI_Background denotes Furthermore, dysregulation of the anti-inflammatory, neurotrophic protein progranulin (PGRN) has been demonstrated in several chronic neurodegenerative diseases.
T4 479-755 DRI_Outcome denotes Here we show that PGRN levels are significantly reduced in conditioned medium of LRRK2(R1441G) mutant mouse fibroblasts, leukocytes, and microglia, whereas levels of proinflammatory factors, like interleukin-1β and keratinocyte-derived chemokine, were significantly increased.
T5 756-856 DRI_Background denotes Decreased PGRN levels were also detected in supernatants of cultured human fibroblasts isolated from
T6 857-877 Token_Label.OUTSIDE denotes presymptomatic LRRK2
T7 877-949 DRI_Background denotes (G2019S) mutation carriers, while mitochondrial function was unaffected.
T8 950-1080 DRI_Background denotes Furthermore, medium levels of matrix metalloprotease (MMP) 2 increased, whereas MMP 9 decreased in LRRK2(R1441G) mutant microglia.
T9 1081-1262 DRI_Outcome denotes Increased proteolytic cleavage of the MMP substrates ICAM-5 and α-synuclein in synaptoneurosomes from LRRK2(R1441G) mutant mouse brain indicates increased net synaptic MMP activity.
T10 1263-1319 DRI_Background denotes PGRN levels were decreased in the cerebrospinal fluid of
T11 1320-1340 Token_Label.OUTSIDE denotes presymptomatic LRRK2
T12 1341-1421 DRI_Background denotes mutant mice, whereas PGRN levels were increased in aged symptomatic mutant mice.
T13 1422-1595 DRI_Background denotes Notably, PGRN levels were also increased in the cerebrospinal fluid of PD patients carrying LRRK2 mutations, but not in idiopathic PD patients and in healthy control donors.
T14 1596-1786 DRI_Outcome denotes Our data suggest that proinflammatory activity of peripheral and brain-resident immune cells may particularly contribute to the early stages of Parkinson's disease caused by LRRK2 mutations.