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UseCases_ArguminSci_Discourse  

PubMed:23396536 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-163 DRI_Background denotes Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy.
T2 164-288 DRI_Challenge denotes Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision.
T3 289-486 DRI_Approach denotes As both mammalian and fly visual systems contain dopaminergic neurons, we investigated the effect of LRRK2 mutations (the most common cause of inherited PD) on Drosophila electroretinograms (ERGs).
T4 487-597 DRI_Outcome denotes We reveal progressive loss of photoreceptor function in flies expressing LRRK2-G2019S in dopaminergic neurons.
T5 598-688 DRI_Background denotes The photoreceptors showed elevated autophagy, apoptosis and mitochondrial disorganization.
T6 689-837 DRI_Background denotes Head sections confirmed extensive neurodegeneration throughout the visual system, including regions not directly innervated by dopaminergic neurons.
T7 838-964 DRI_Outcome denotes Other PD-related mutations did not affect photoreceptor function, and no loss of vision was seen with kinase-dead transgenics.
T8 965-1099 DRI_Background denotes Manipulations of the level of Drosophila dLRRK suggest G2019S is acting as a gain-of-function, rather than dominant negative mutation.
T9 1100-1234 DRI_Background denotes Increasing activity of the visual system, or of just the dopaminergic neurons, accelerated the G2019S-induced deterioration of vision.
T10 1235-1477 DRI_Outcome denotes The fly visual system provides an excellent, tractable model of a non-autonomous deficit reminiscent of that seen in PD, and suggests that increased energy demand may contribute to the mechanism by which LRRK2-G2019S causes neurodegeneration.